Chemotherapy-Induced Toxicity

Name	AC	CK
Curcumin	60	103
Magnesium	10	94
Ginsenosides	29	67
Vitamin E	11	47
Thymoquinone	19	37
Chokeberry	4	32
Ginger	12	31
Resveratrol	17	31
Homeopathic Medicine: Traumeel	2	30
Bee Propolis	3	28
Melatonin	12	28
Alpha-Lipoic Acid	10	27
NAC (N-acetyl-L-cysteine)	10	26
Nigella sativa (aka Black Seed)	14	26
Reishi Mushroom	9	26
Vitamin C	15	25
Probiotics	8	24
Coenzyme Q10	7	23
Folic Acid	2	22
Grape Seed Extract	10	22
Silibinin	2	22
Sulforaphane	12	22
Oleuropein	7	21
Acetyl-l-carnitine	2	20
Calendula	1	20
Ellagic Acid	10	20
Flavonoids	12	20
Garlic	11	20
Homeopathic Medicine: All	1	20
Royal Jelly	6	20
Sodium Bicarbonate	1	20
Vitamin B-12	1	20
Wheat Grass	1	20
Astaxanthin	10	19
Caffeic acid phenethyl ester	9	19
Onion	4	19
Rutin	11	19
Astragaloside	8	18
Carnitine	4	18
L-Carnitine	4	16
Chrysin	9	15
Citrus naringin	8	15
Genistein	5	15
Zataria multiflora	8	15
Astragalus	4	14
Ginkgo biloba	7	14
Isoflavones	4	14
Quercetin	11	14
EGCG (Epigallocatechin gallate)	8	13
Naringenin	6	13
Neem	3	13
Anthocyanins	7	12
Cannabidiol	6	12
Codonopsis pilosula	2	12
Echinacea	2	12
Ginseng	7	12
Green Tea	5	12
Palmitoylethanolamide	2	12
Panax Notoginseng	5	12
Pomegranate	8	12
St. Johns Wort	2	12
Vitamin D	2	12
Wheat Germ	2	12
Angelica	2	11
Cannabis	2	11
Glutamine	2	11
Paeonol	6	11
Tanshinone IIA	7	11
AHCC	3	10
Allicin	5	10
Bifidobacterium	1	10
Bifidobacterium Breve	1	10
Caffeine	1	10
Carvacrol	5	10
Cordyceps sinensis	5	10
Geranium	1	10
Ginseng (Korean)	5	10
Honey: Life Mel Proprietary Formula	1	10
Honokiol	6	10
Lactobacillus plantarum	5	10
Medicinal Mushrooms	5	10
Multivitamin	1	10
Saccharomyces Boulardii	1	10
Saffron	4	10
Apigenin	6	9
Asiatic Acid	5	9
Chrysanthemum Indicum	3	9
Crocin	5	9
Hesperidin	5	9
Maitake Mushroom	4	9
Spirulina	4	9
Berberine	5	8
Beta-glucan	3	8
Betulinic acid	3	8
Camel Milk	4	8
Flaxseed	4	8
Lycopene	4	8
Mangosteen	2	8
P-Coumaric Acid	5	8
Panax Ginseng	4	8
Fermented Foods and Beverages	4	7
Fucoidan	5	7
Honey	4	7
Indole-3-Carbinol	4	7
Licorice	5	7
Mangiferin	4	7
Myricetin	4	7
Paeoniflorin	5	7
Rosmarinic acid	4	7
Schisandra	3	7
Selenium	4	7
Arginine	3	6
Bael	3	6
Ferulic acid	5	6
Fig	3	6
Gingerol	3	6
Grape	4	6
Huaier (Trametes robiniophila murr)	3	6
Olive leaf extract	3	6
Pomegranate Seed	2	6
Puerarin	3	6
Pycnogenol (Pine Bark)	3	6
Red Sage	3	6
Safflower	3	6
Taurine	3	6
Urolithin A	3	6
White Tea	3	6
Blueberry	3	5
Cordyceps Militaris	3	5
Dates	3	5
Gold (nanoparticles)	3	5
Ligustrazine	3	5
Lotus	5	5
Sesamol	4	5
Soy	1	5
Amla Fruit	2	4
Bacopa	2	4
Bai Zhu	2	4
Beta-Caryophyllene	2	4
Bile salts	1	4
Bitter Apple	2	4
Blackberry	2	4
Cannabinoids	3	4
Clove	2	4
Delta-tetrahydrocannabinol (THC)	2	4
Diallyl sulfide	2	4
Eugenol	2	4
Fenugreek	2	4
Fisetin	2	4
Gallic Acid	2	4
Garlic: Aged	2	4
Geraniol	2	4
Gotu Kola	2	4
Hawthorn	2	4
Hydrogen Water	2	4
Lactobacillus Acidophilus	2	4
Lactobacillus paracasei	2	4
Lactobacillus rhamnosus	2	4
Lemon Peel	1	4
Luteolin	3	4
Milk Thistle	2	4
Moringa oleifera	2	4
Nordihydroguaiaretic acid (NDGA)	2	4
Oleanolic acid	2	4
Oligosaccharides	2	4
Omega-3 Fatty Acids	2	4
Parsley	2	4
Patchouli	2	4
Phloretin	3	4
Piperidines	1	4
Piperine	2	4
Plantago	2	4
Polyphenols	3	4
Pomegranate Peel	2	4
Pumpkin Seeds	2	4
Punicalagin	3	4
Red Wine Extract	1	4
Rhubarb	2	4
Rosemaric Acid	3	4
Rubia Cordifolia	1	4
Seaweed: Brown	2	4
Spikenard	2	4
Tangeretin	3	4
Tannic Acid	2	4
Testosterone	1	4
Vanillin	2	4
Walnut	2	4
Achiote	2	3
Aloe Vera	2	3
Bee Venom	2	3
Emodin	3	3
Formononetin	2	3
Peony	2	3
Poria cocos	2	3
Riboflavin (Vitamin B-2)	2	3
Sea buckthorn	2	3
Vitamin E: alpha tocopherol	2	3
Watercress	2	3
White Mulberry	2	3
Wogonin	2	3
Apricot Kernel	1	2
Artemisinin	1	2
Ashwagandha	1	2
Barberry	1	2
Basil	1	2
Bee Pollen	1	2
Bergamot	1	2
Betaine	1	2
Betanin	1	2
Bifidobacterium Bifidum	1	2
Bifidobacterium Lactis	1	2
Bilberry	1	2
Biochanin A	1	2
Bitter Orange	1	2
Bixin	2	2
Boerhaavia diffusa	1	2
Buckwheat	1	2
Carrot	1	2
Catechols	1	2
Celery	1	2
Chickpea	1	2
Chlorella (Algae)	1	2
Cinnamaldehyde	1	2
Cinnamic acid	1	2
Citrus Peel	1	2
Coconut Husk/Fiber	1	2
Coconut Oil	1	2
Coriandrum sativum	1	2
Corn Silk	1	2
Corn: Purple	1	2
Crocetin	1	2
Curry Leaves	1	2
Cyanidin 3-glucoside	1	2
D-Limonene	1	2
Diosgenin	1	2
Dogwood	1	2
Eriodictyol	1	2
Eucalyptus	1	2
Evening Primrose Oil	1	2
Fucoxanthin	1	2
Ginseng (American)	1	2
Glycyrrhizin	1	2
Goji	1	2
Grapes	1	2
Guava	1	2
Guduchi	1	2
Hazelnut	1	2
Hemp Seed	1	2
Hibiscus sabdariffa	1	2
Homeopathic Arsenicum album	1	2
Honeysuckle	1	2
Horehound	1	2
Horsetail	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrangea	1	2
Indian Mulberry	1	2
Kaempferol	1	2
Kefir	1	2
Kimchi	1	2
Kombucha Tea	1	2
Lactobacillus casei	1	2
Lecithin	1	2
Liquiritigenin	1	2
Loquat Seeds	1	2
Lutein	1	2
Lychee	1	2
Magnolol	1	2
Mango	1	2
Manuka Honey	1	2
Marjoram	1	2
Meadowsweet	1	2
Methionine	1	2
Modified Citrus Pectin	1	2
Mustard Greens	1	2
Nettle	1	2
Nobiletin	1	2
Noni	1	2
Okra	1	2
Olive Oil	1	2
Orange	1	2
Orange: Mandarin	1	2
Organosulfur Compounds	1	2
Orthosiphon	1	2
Passion fruit	1	2
Pine Bark Extract	1	2
Plantago major	1	2
Prickly Pear Cactus	1	2
Pterostilbene	1	2
Purslane	1	2
Quince	1	2
Raspberry	1	2
Raspberry ketone	1	2
Rehmannia	2	2
Rooibos	2	2
Salvia miltiorrhiza	1	2
Sandalwood	1	2
Seaweed	1	2
Sesamin	1	2
Silver (nanoparticles)	1	2
Silymarin	1	2
Soup	1	2
Stilbenes	1	2
Strawberry	1	2
Sumac	1	2
Superoxide dismutase	1	2
Tetrahydrocurcumin	1	2
Theanine	1	2
Thyme	1	2
Thymol	1	2
Tocotrienol: Delta	2	2
Trichosanthes Kirilowii	1	2
Turmeric	1	2
Turmeric: Fermented	1	2
Ursolic Acid	1	2
Vitamin E: Gamma-Tocopherol	1	2
Vitexins	1	2
Water: Deep Sea	2	2
Water: Deuterium Depleted	1	2
Woodfordia fruticosa	1	2
Xanthohumol	1	2
Yarrow	1	2
Zinc	1	2
18β-Glycyrrhetinic Acid	1	1
Alpha Linolenic Acid	1	1
Antrodia cinnamomea	1	1
Benzyl isothiocyanate	1	1
Bisdemethoxycurcumin	1	1
Black Tea	1	1
Caffeic Acid	1	1
Camu Camu	1	1
Capparis spinosa (caper)	1	1
Capsaicin	1	1
Catechin	1	1
Celastrol	1	1
Curcuminoids	1	1
Cysteine (see N-Acetylcysteine)	1	1
Daidzein	1	1
Eggplant	1	1
Genipin	1	1
Gold	1	1
Hyperforin	1	1
Isoliquiritigenin	1	1
Jujube	1	1
Lettuce	1	1
Marijuana	1	1
Persimmon	1	1
Phyllanthus urinaria	1	1
Piceatannol	1	1
Pumpkin	1	1
Rice Bran	1	1
Rosemary	1	1
Sweet Orange	1	1
Tocotrienols	1	1

Name	AC	CK
Cisplatin	14	42
Cyclophosphamide	14	30
Chemotherapy	2	22
Doxorubicin	7	13
Paclitaxel	5	12
Atorvastatin	1	10
Dl-alpha-tocopherol acetate	1	10
Tamoxifen	1	10
Bleomycin	3	9
Arsenic Trioxide	4	6
Fluorouracil (5-FU or f5U)	3	5
Nicotine	3	3
Acetaminophen	1	2
Monosodium Glutamate (MSG)	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Paracetamol	1	2
Benzo(a)pyrene	1	1
Bisphenol A	1	1
Cadmium	1	1
Cyclosporins	1	1
Isoproterenol	1	1
Methotrexate	1	1
Streptozotocin	1	1

Name	AC	CK
Cryotherapy	3	31
Exercise	3	24
Dietary Modification: Mediterranean Diet	1	10
Fasting/Caloric Restriction	1	10
Homeopathic Treatment	1	10
Hyperbaric Treatment	2	5
Laser Treatment: Low-Level	2	3
Dietary Modification: Low Calorie Diet	1	2
Exercise: Aerobic	1	2
Light-Emitting Diodes (LEDs) Therapy	1	2
Microbiota Transfer Therapy	1	2
Traditional Chinese Medicine	1	2
Guided Imagery	1	1
Ozone Therapy	1	1

Name	AC	CK
Chemotherapy	11	71
Radiotherapy	2	12
Electromagnetic Field Harms	1	1
Electromagnetic Radiation	1	1

Click here to read the entire abstract

Pubmed Data : Int J Clin Oncol. 2020 Aug 1. Epub 2020 Aug 1. PMID: 32740717

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer

Pharmacological Actions : Chemoprotective Agents

[+]

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicityDec 12, 2016

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Pubmed Data : Support Care Cancer. 2016 Dec 13. Epub 2016 Dec 13. PMID: 27966021

Pubmed Data : Support Care Cancer. 2010 Jun;18(6):751-9. Epub 2009 Aug 14. PMID: 19685085

Article Published Date : Jun 01, 2010

Study Type : Human Study

Additional Links

Substances : Bifidobacterium, Bifidobacterium Breve, Probiotics

Diseases : Chemotherapy-Induced Toxicity

[+]

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.Dec 01, 2008

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Pubmed Data : Exp Neurol. 2008 Dec;214(2):276-84. Epub 2008 Sep 9. PMID: 18809400

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy

Pharmacological Actions : Neuroprotective Agents

[+]

An intravenous hydration regimen supplemented with magnesium prevented cisplatin-induced nephrotoxicity in patients with head and neck cancer.Feb 01, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Otolaryngol Head Neck Surg. 2018 Feb 2 ;47(1):10. Epub 2018 Feb 2. PMID: 29394952

[+]

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

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Pubmed Data : Melanoma Res. 2002 Feb;12(1):83-90. PMID: 11828262

Article Published Date : Feb 01, 2002

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Melanoma

Problem Substances : Dl-alpha-tocopherol acetate

[+]

Effects of photobiomodulation (660 nm laser) on anthracycline extravasation.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Rev Lat Am Enfermagem. 2022 ;30:e3693. Epub 2022 Oct 17. PMID: 36287401

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pharmacol Toxicol. 2014 ;15:70. Epub 2014 Dec 4. PMID: 25472655

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer

Pharmacological Actions : Chemoprotective Agents, Renoprotective

Additional Keywords : Significant Treatment Outcome , Supplementation

[+]

Intravenous magnesium supplementation conferred protective effects against cisplatin-induced nephrotoxicity.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(17):7517-22. PMID: 26625755

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Onion

Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic

Additional Keywords : Dietary Modification

[+]

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

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Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931

Saccharomyces boulardii has significant therapeutic activity in irinotecan-induced (chemotherapy) diarrhea and mucositis.Dec 09, 2008

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Pubmed Data : Med Oncol. 2008 Dec 9. PMID: 19067257

Article Published Date : Dec 09, 2008

Study Type : Human Study

Additional Links

Substances : Saccharomyces Boulardii

Diseases : Chemotherapy-Induced Toxicity, Diarrhea, Mucositis

Additional Keywords : Drug: Iriniotecan

[+]

Short term fasting during chemotherapy was well tolerated and reduced hematological toxicity of TAC in HER2-negative BC patients.Oct 04, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2015 Oct 5 ;15:652. Epub 2015 Oct 5. PMID: 26438237

Article Published Date : Oct 04, 2015

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin, DNA damage

Therapeutic Actions : Fasting/Caloric Restriction

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Risk Reduction

[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

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Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005

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Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukemia: Acute myelogenous leukemia (AML) , Lymphoma, Myelodysplastic Syndrome, Radiation Induced Illness

Additional Keywords : Iatrogenic Disease

Anti Therapeutic Actions : Chemotherapy, Radiotherapy

[+]

These results demonstrated the feasibility of a dietary antioxidant supplementation in order to prevent the cisplatin induced hearing damage.Jan 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Heliyon. 2017 Feb ;3(2):e00251. Epub 2017 Feb 20. PMID: 28239674

Article Published Date : Jan 31, 2017

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Multivitamin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents

[+]

TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.Aug 01, 2001

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Pubmed Data : Cancer. 2001 Aug 1;92(3):684-90. PMID: 11505416

Article Published Date : Aug 01, 2001

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Environ Res Public Health. 2016 ;13(2). Epub 2016 Feb 19. PMID: 26907305

Article Published Date : Dec 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Onion

Diseases : Chemotherapy-Induced Toxicity: Bleomycin

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Plant Extracts

Problem Substances : Bleomycin

[+]

Protective effects of crocetin on arsenic trioxide-induced oxidative stress.Oct 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2021 Nov-Dec;35(6):3157-3163. PMID: 34697146

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Article Publish Status : This is a free article. Click here to read the complete article.

Puerarin activates adaptive autophagy and protects the myocardium against doxorubicin-induced cardiotoxicity.Aug 31, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Sep ;153:113403. Epub 2022 Jul 13. PMID: 36076529

Article Published Date : Aug 31, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity.Dec 25, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy."Feb 14, 2012

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Pubmed Data : Clin Cancer Res. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22338017

Article Published Date : Feb 14, 2012

Pubmed Data : Clin Exp Pharmacol Physiol. 2016 Apr 30. Epub 2016 Apr 30. PMID: 27130783

Article Published Date : Apr 29, 2016

Study Type : Animal Study

Additional Links

Diseases : Anorexia: Cancer-Associated, Cachexia: Chemotherapy Induced, Chemotherapy-Induced Toxicity: 5-fluorouracil

Problem Substances : Fluorouracil (5-FU or f5U)

[+]

6-gingerol ameliorates cisplatin-induced pica.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2020 ;14:4085-4099. Epub 2020 Oct 2. PMID: 33061309

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents

[+]

6-gingerol was as effective as ondansetron in the treatment of pica induced by cisplatin.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2017 Jan-Feb;49(1):65-70. PMID: 28458425

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

A combination of virgin coconut oil and extra virgin olive oil elicits superior protection against doxorubicin cardiotoxicity in rats.Jan 28, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk J Pharm Sci. 2022 04 29 ;19(2):138-144. PMID: 35509244

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2014 ;14(1):92. Epub 2014 Sep 28. PMID: 25298749

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective

Additional Keywords : Plant Extracts

[+]

Aged garlic extract and grape seed proanthocyanidin protect against doxorubicin-induced cardiotoxicity.Aug 01, 2009

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Pubmed Data : Can J Physiol Pharmacol. 2009 Aug;87(8):633-40. PMID: 19767888

Article Published Date : Mar 03, 2021

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

[+]

Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity.Nov 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):143-8. Epub 2009 Jul 28. PMID: 19643175

Article Published Date : Oct 29, 2009

Study Type : Animal Study

Additional Links

Substances : Orange: Mandarin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Apr 22 ;182:101-9. Epub 2016 Feb 10. PMID: 26875643

Article Published Date : Apr 21, 2016

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Fertility Agents: Male

Additional Keywords : Plant Extracts

Problem Substances : Cyclophosphamide

[+]

An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

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Pubmed Data : J Ethnopharmacol. 2018 Apr 6 ;215:191-198. Epub 2018 Jan 9. PMID: 29325915

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Pubmed Data : J Food Biochem. 2021 09 ;45(9):e13869. Epub 2021 Jul 19. PMID: 34287964

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Sweet Potato: Purple

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice.Dec 31, 2015

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Pubmed Data : J Infect Chemother. 2016 Jan ;22(1):36-43. Epub 2015 Nov 19. PMID: 26603425

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Pubmed Data : Lipids. 2016 Jun 4. Epub 2016 Jun 4. PMID: 27262314

Article Published Date : Jun 03, 2016

Study Type : Animal Study

Additional Links

Substances : Apricot Kernel

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Problem Substances : Cyclophosphamide

[+]

Arsenicum Album 6C and 30C remedies indicated potentials of use against arsenic intoxication.Dec 31, 2007

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pathobiology. 2008 ;75(3):156-70. PMID: 18550913

Article Published Date : Dec 31, 2007

Study Type : Animal Study

Additional Links

Substances : Homeopathic Arsenicum album

Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide

Pharmacological Actions : Chemoprotective Agents

[+]

Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity.Jan 31, 2020

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Pubmed Data : Biotech Histochem. 2020 Feb ;95(2):121-128. Epub 2019 Sep 6. PMID: 32064961

Pharmacological Actions : Chemoprotective Agents, MicroRNA modulator

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Astragaloside IV attenuates the myocardial injury caused by adriamycin by inhibiting autophagy.Dec 31, 2020

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Pubmed Data : Biochem Pharmacol. 2020 Oct 24 ;183:114299. Epub 2020 Oct 24. PMID: 33148504

Article Published Date : Oct 23, 2020

Study Type : Animal Study

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Substances : Astragaloside

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

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Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury.Jan 27, 2020

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Pubmed Data : J Ethnopharmacol. 2020 Jan 28 ;252:112637. Epub 2020 Jan 28. PMID: 32004631

Article Published Date : Jan 27, 2020

Study Type : Animal Study

Additional Links

Substances : Astragalus, Panax Notoginseng

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Bacopa monnieri may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.Mar 31, 2017

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Pubmed Data : J Pharmacol Sci. 2017 Apr ;133(4):232-239. Epub 2017 Mar 12. PMID: 28363413

Article Published Date : Mar 31, 2017

Study Type : Animal Study

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Substances : Bacopa

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Emesis

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Natural Substances Versus Drugs

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Pubmed Data : Biomed Pharmacother. 2022 Jul ;151:113097. Epub 2022 May 24. PMID: 35609366

Article Published Date : Jun 30, 2022

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, SIRT1 Activator

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Berberine exhibited protective effects against doxorubicin induced heart tissue free radical injury.Mar 31, 2018

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Pubmed Data : Am J Med Sci. 2022 Apr 12. Epub 2022 Apr 12. PMID: 35427583

Article Published Date : Apr 11, 2022

Study Type : Animal Study

Additional Links

Substances : Barberry

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective

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Beta-glucan might be useful against cisplatin toxicity in patients with cancer in terms of nervous system.Feb 29, 2016

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Pubmed Data : Biofactors. 2007;29(1):55-65. PMID: 17611294

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Pubmed Data : J Complement Integr Med. 2017 Dec 13. Epub 2017 Dec 13. PMID: 29236674

Article Published Date : Dec 12, 2017

Study Type : Animal Study

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Substances : Bitter Apple

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Renoprotective

[+]

Bitter apple pretreatment attenuates cyclophosphamide-induced oxidative stress and the subsequent DNA damage in mice.Dec 31, 2012

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Pubmed Data : ScientificWorldJournal. 2013 ;2013:980480. Epub 2013 Nov 7. PMID: 24324391

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Pubmed Data : ACS Omega. 2022 Apr 26 ;7(16):13697-13703. Epub 2022 Apr 14. PMID: 35559194

Article Published Date : Apr 25, 2022

Study Type : Animal Study

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Substances : Frankincense

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Brassica rapa (Mustard Greens) have a protective effect on cisplatin-induced nephrotoxicity in cells and rats. Dec 01, 2006

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Pubmed Data : Biol Pharm Bull. 2006 Dec;29(12):2436-41. PMID: 17142978

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:8424872. Epub 2019 Jul 29. PMID: 31467580

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

Additional Keywords : C-phycocyanin

[+]

C. indicum ethanol extract could attenuate cisplatin-induced nephrotoxicity and might be a beneficial agent for acute renal failure management.Feb 28, 2015

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Pubmed Data : Nat Prod Commun. 2015 Mar ;10(3):397-402. PMID: 25924514

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Pubmed Data : Front Cardiovasc Med. 2022 ;9:695004. Epub 2022 Jul 5. PMID: 35865382

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Heart Failure

Pharmacological Actions : Cardioprotective, Chemoprotective Agents, MicroRNA modulator

[+]

Cardioprotective effect of Rheum turkestanicum against doxorubicin-induced toxicity.Dec 31, 2021

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Pubmed Data : J Med Food. 2017 Oct ;20(10):944-950. Epub 2017 Aug 17. PMID: 28816580

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Pubmed Data : Oral Dis. 2020 May 13. Epub 2020 May 13. PMID: 32400905

Article Published Date : May 12, 2020

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil , Oral Mucositis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents

[+]

Celery has a protective effect against doxorubicin toxicity. Jan 01, 2009

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Pubmed Data : Molecules. 2009 ;14(4):1627-38. Epub 2009 Apr 24. PMID: 19396021

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Celery

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Lipid Peroxidation

Pharmacological Actions : Antioxidants

Additional Keywords : Drug: Doxorubicin, Plant Extracts

[+]

Chemoprotective role of an extract of the heart of the Phoenix dactylifera tree on adriamycin-induced cardiotoxicity and nephrotoxicity.Dec 31, 2019

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Pubmed Data : Food Chem Toxicol. 2020 Jan ;135:111045. Epub 2019 Dec 9. PMID: 31830546

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Pubmed Data : J Biochem Mol Toxicol. 2015 Jun 24. Epub 2015 Jun 24. PMID: 26108916

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Pubmed Data : Pharmaceuticals (Basel). 2022 Nov 13 ;15(11). Epub 2022 Nov 13. PMID: 36422526

Article Published Date : Nov 12, 2022

Study Type : Animal Study

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Substances :

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Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

There are high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapyAug 08, 2011

There is evidence to support the use of topical calendula for prophylaxis of acute dermatitis during radiotherapy and Traumeel S mouthwash in the treatment of chemotherapy-induced stomatitis. Jan 01, 2009

These results highlight the potential protective effect of magnesium supplementation on cisplatin-induced acute nephrotoxicity.Aug 18, 2019

A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

A proprietary honey-based herbal formula reduces chemotherapy-induced neutropenia and the need for colony-stimulating factors.Jan 01, 2006

A short hydration regimen with 20 mEq of magnesium supplementation is safe and feasible for patients with lung cancer receiving cisplatin-based chemotherapy.Jul 31, 2020

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicityDec 12, 2016

A. melanocarpa may be regarded as a promising new source of bioactive antioxidant natural compounds for breast cancer patients.Feb 28, 2013

Acetyl L-carnitine treatment improves symptoms of chemotherapy induced neuropathy. Aug 01, 2005

Acetyl-L-carnitine appears to be an effective and well-tolerated agent for the treatment of chemotherapy-induced peripheral neuropathy.Mar 01, 2005

Acute exercise protects against doxorubicin cardiotoxicity.Sep 01, 2008

Adjunctive oral cryotherapy is effective for the prophylaxis and relief of oral mucositis and anorexia caused by chemotherapy.Dec 31, 2018

Administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies improves their intestinal environments.Jun 01, 2010

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.Dec 01, 2008

An intravenous hydration regimen supplemented with magnesium prevented cisplatin-induced nephrotoxicity in patients with head and neck cancer.Feb 01, 2018

Astragalus may provide an ideal complementary treatment to chemotherapy.Mar 01, 2008

Atorvastatin causes cardiomyopathy when administered in combination with chemotherapy.Jul 01, 2007

Bee honey and royal jelly are effective in reducing cisplatin nephrotoxicity.May 25, 2017

Bi-weekly administration of paclitaxel and cisplatin in patients with advanced esophageal cancer results in amedian survival for all patients of 9 months.Mar 04, 2002

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

Cannabis extract is safe and efficacious in reducing chemotherapy-induced nauseau and vomiting.Nov 01, 2010

Carnitine improves fatigue, quality of life, lean body mass and appetite in advanced cancer patients undergoing anticancer therapy. Feb 01, 2006

Chemotherapy used in advanced gastric or gastroesophageal adenocarcinoma results in an overall median survival time of between 7-9 months.Mar 20, 2010

Children treated for solid tumors or lymphoma with chemotherapy have increased caries of the primary teeth.Jan 01, 2010

Cisplatin-associated severe acute kidney injury occurs in 20% of the patients and has a negative impact on long-term renal function and patient survival.Dec 31, 2014

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

Effects of photobiomodulation (660 nm laser) on anthracycline extravasation.Dec 31, 2021

Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction.Oct 05, 2006

Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric patients.Oct 01, 2004

Ginger root powder is effective in reducing severity of acute and delayed chemotherapy-induced nausea and vomiting as additional therapy to ondensetron and dexamethasone in patients receiving chemotherapy.Sep 14, 2010

High-volume hydration and magnesium supplementation can reduce the renal toxicity induced by cisplatin.Dec 31, 2013

Intravenous magnesium supplementation conferred protective effects against cisplatin-induced nephrotoxicity.Dec 31, 2017

L-carnitine could enhance the spermatogenesis process after exposure to cisplatin during the prepubertal phase.Aug 08, 2020

Magnesium supplementation during cisplatin-containing chemotherapy was associated with less cisplatin-induced nephrotoxicity.Apr 19, 2018

Magnesium was found to provide nephroprotective effects among patients with cervical cancer undergoing chemotherapy with cisplatin alone.Mar 31, 2015

Manipulation of diet through high intake of yellow onion is a promising possibly to improve the synergistic effect in DOX-based chemotherapy.Dec 31, 2014

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Oral cryotherapy prevents oral mucositis and pain among patients with colorectal cancer undergoing chemotherapy.Dec 31, 2017

Oral glutamine supplementation protects lymphocytes and attenuates gut permeability in patients with esophageal cancer during radiochemotherapy.Apr 01, 1998

Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients.Apr 15, 2021

Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma. Dec 31, 2012

Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy.Nov 30, 2011

Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy.Mar 01, 2002

Propolis plus bicarbonate was safe, well tolerated and promisingly effective in the prevention of oral mucositis in patients with breast cancer.Oct 31, 2017

Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer.Aug 16, 2022

Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies.Dec 23, 2019

Saccharomyces boulardii has significant therapeutic activity in irinotecan-induced (chemotherapy) diarrhea and mucositis.Dec 09, 2008

Short term fasting during chemotherapy was well tolerated and reduced hematological toxicity of TAC in HER2-negative BC patients.Oct 04, 2015

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Soy isoflavones ameliorate the adverse effects of chemotherapy in children.Oct 01, 1996

The cisplatin total dose had a significant negative relationship with magnesium levels at 12 months in this study. Jul 31, 2015

The decrease in neutrophil count caused by breast carcinoma chemotherapy was ameliorated by dietary supplementation with a multivitamin or vitamin E.Sep 01, 2004

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

These results demonstrated the feasibility of a dietary antioxidant supplementation in order to prevent the cisplatin induced hearing damage.Jan 31, 2017

TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.Aug 01, 2001

Vitamin E and N-acetylcysteine are an effective antioxidant adjuvant therapy in children with acute lymphoblastic leukemia to reduce the chemo-/radiotherapy toxicity of treatment. Jan 01, 2009

Wheat grass juice may reduce myelotoxicity and need for granulocyte colony-stimulating factors in breast cancer patients receiving chemotherapy.Jan 01, 2007

Glycine max and Chrysanthemum indicum extracts exhibited a promising protective effect on cisplatin-induced nephrotoxicity.Nov 30, 2011

Onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes.Dec 31, 2015

Protective effects of crocetin on arsenic trioxide-induced oxidative stress.Oct 31, 2021

Self-assembled betulinic acid can be used to ameliorate the cytotoxic effects of Doxorubicin.Apr 30, 2015

These findings indicate that the protective effects of low-dose BBR against DOX-induced cardiotoxicity are mediated by Bcl-xL.Apr 29, 2022

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

Baicalein enhances the expansion of hematopoietic and progenitor stem cells and alleviates 5-fluorouracil-induced myelosuppression.Feb 02, 2023

Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.Nov 17, 2022

Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis.Apr 30, 2022

Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis.Mar 22, 2018

Icariin exhibits protective effects on cisplatin-induced cardiotoxicity.Aug 31, 2022

In vitro and in vivo nephroprotective effects of Nelumbo nucifera seedpod extract against cisplatin-induced renal injury.Dec 01, 2022

Chemotherapy-Induced Toxicity

View the Evidence:
1240 Abstracts with Chemotherapy-Induced Toxicity Research