Chemotherapy-Induced Toxicity: Bleomycin

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56 Substances Researched for Chemotherapy-Induced Toxicity: Bleomycin
NameACCKFocus
Curcumin816Locked
Flavonoids711Locked
Ginkgo biloba511Locked
Tanshinone IIA48Locked
Onion15Locked
Alpha-Lipoic Acid24Locked
Ginsenosides24Locked
Resveratrol24Locked
Walnut24Locked
Astragaloside23Locked
Diosgenin13Locked
Piceatannol 23Locked
Quercetin23Locked
Arctigenin12Locked
Ashwagandha12Locked
Baicalein12Locked
Betanin12Locked
Carnitine12Locked
Chrysanthemum Indicum12Locked
Cordyceps Militaris12Locked
Cordyceps sinensis12Locked
EGCG (Epigallocatechin gallate)12Locked
Ellagic Acid12Locked
Fisetin12Locked
Flaxseed12Locked
Gallic Acid12Locked
Garlic12Locked
Ginger12Locked
Gotu Kola12Locked
Hu Zhang (Polygonum cuspidatum)12Locked
Kefir12Locked
Lecithin12Locked
Medicinal Mushrooms12Locked
Olive leaf extract12Locked
Orange: Mandarin12Locked
Palmitoylethanolamide 12Locked
Panax Notoginseng12Locked
Passion fruit12Locked
Red Sage12Locked
Reishi Mushroom12Locked
Royal Jelly12Locked
Safflower12Locked
Salvia miltiorrhiza12Locked
Sea Cucumber12Locked
Sesame Seeds12Locked
Sesamol12Locked
St. Johns Wort12Locked
Superoxide dismutase12Locked
Thymoquinone12Locked
Andrographis11Locked
Citrus naringin11Locked
Fenugreek11Locked
Honokiol11Locked
Paeoniflorin11Locked
Polyphenols11Locked
Rose 11Locked
2 Problem Substances Researched for Chemotherapy-Induced Toxicity: Bleomycin
NameACCKFocus
Dl-alpha-tocopherol acetate110Locked
Bleomycin39Locked
2 Problematic Actions Researched for Chemotherapy-Induced Toxicity: Bleomycin
NameACCKFocus
Electromagnetic Field Harms11Locked
Electromagnetic Radiation11Locked
Related Topics

Chemotherapy-Induced Toxicity: Bleomycin is a Sub of the following Topic

View the Evidence:
80 Abstracts with Chemotherapy-Induced Toxicity: Bleomycin Research

[+]

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

Pubmed Data : Melanoma Res. 2002 Feb;12(1):83-90. PMID: 11828262
Article Published Date : Feb 01, 2002
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Melanoma
Problem Substances : Dl-alpha-tocopherol acetate
[+]

Onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2016 ;13(2). Epub 2016 Feb 19. PMID: 26907305
Article Published Date : Dec 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Onion
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Plant Extracts
Problem Substances : Bleomycin
[+]

Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis.Apr 30, 2022

Pubmed Data : Drug Chem Toxicol. 2022 May ;45(3):1264-1275. Epub 2020 Sep 14. PMID: 32924642
Article Published Date : Apr 30, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Ginkgolic acid improves bleomycin-induced pulmonary fibrosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:8002566. Epub 2022 Jun 6. PMID: 35707278
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice.Nov 23, 2021

Pubmed Data : Hum Exp Toxicol. 2021 Nov 24:9603271211048184. Epub 2021 Nov 24. PMID: 34818114
Article Published Date : Nov 23, 2021
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
[+]

A Chinese herbal formula containing Red Sage, Cordyceps and Peach kernel is superior to methylprednisone against experimental pulmonary fibrosis. May 01, 2007

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):835-9. PMID: 17639988
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Alpha lipoic acid attenuates bleomycin-induced pulmonary fibrosis in mice. Jun 01, 2007

Pubmed Data : Int J Mol Med. 2007 Jun;19(6):865-73. PMID: 17487418
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Amelioration of bleomycin and methotrexate-induced pulmonary toxicity by serratiopeptidase and fisetin.Dec 22, 2020

Pubmed Data : Nutr Cancer. 2020 Dec 23:1-10. Epub 2020 Dec 23. PMID: 33353415
Article Published Date : Dec 22, 2020
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Chemoprotective Agents
[+]

Amelioration of bleomycin induced pulmonary fibrosis by administration of Salvianolic acid B.Nov 17, 2022

Pubmed Data : Vet Ital. 2022 Nov 18 ;58(1):87-101. Epub 2022 Nov 18. PMID: 36398675
Article Published Date : Nov 17, 2022
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Ameliorative effects of arctigenin on pulmonary fibrosis induced by bleomycin via the antioxidant activity.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:3541731. Epub 2022 Jul 5. PMID: 35847593
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemoprotective Agents
[+]

An extract of Mandarin Orange demonstrates anti-pulmonary fibrosis effects. Oct 29, 2009

Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):143-8. Epub 2009 Jul 28. PMID: 19643175
Article Published Date : Oct 29, 2009
Study Type : Animal Study
Additional Links
Substances : Orange: Mandarin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Antifibrotic mechanism of piceatannol in bleomycin-induced pulmonary fibrosis in mice.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:771031. Epub 2022 Jun 7. PMID: 35747752
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment.Apr 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 May ;89:1297-1309. Epub 2017 Mar 17. PMID: 28320097
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Astragaloside IV mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis.Sep 30, 2016

Pubmed Data : Inflammation. 2016 Oct ;39(5):1835-41. PMID: 27525425
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents
[+]

Attenuation of bleomycin-induced pulmonary fibrosis by quercetin and gallic acid.Dec 31, 2020

Pubmed Data : Nutr Cancer. 2021 ;73(10):2039-2049. Epub 2020 Sep 16. PMID: 32933341
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Gallic Acid, Quercetin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2023 Dec ;61(1):288-297. PMID: 36815239
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Baicalein
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Baicalin alleviates bleomycin-induced early pulmonary fibrosis.Sep 30, 2023

Pubmed Data : Toxicology. 2023 Oct ;497-498:153638. Epub 2023 Sep 30. PMID: 37783230
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic
[+]

Betanin protects against bleomycin-induced pulmonary fibrosis.Jan 01, 2024

Pubmed Data : Food Funct. 2024 Jan 2 ;15(1):284-294. Epub 2024 Jan 2. PMID: 38083874
Article Published Date : Jan 01, 2024
Study Type : Animal Study
Additional Links
Substances : Betanin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Feb 24 ;18(3). Epub 2017 Feb 24. PMID: 28245556
Article Published Date : Feb 23, 2017
Study Type : Animal Study
Additional Links
Substances : Chrysanthemum Indicum
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Cordyceps alleviates bleomycin-induced alveolitis and fibrosis. Dec 01, 2007

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2623-7. PMID: 18338602
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Cordyceps militaris treatment significantly alleviated the severity of bleomycin-induced acute lung injury in mice.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2015 ;36(5):2003-11. Epub 2015 Jul 17. PMID: 26202360
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
[+]

Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.Mar 01, 2007

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2007 Mar;30(3):197-201. PMID: 17572999
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Alveolitis: Fibrosing, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis. Jun 13, 2007

Pubmed Data : J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272
Article Published Date : Jun 13, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.Sep 01, 2000

Pubmed Data : Br J Pharmacol. 2000 Sep;131(2):169-72. PMID: 10991907
Article Published Date : Sep 01, 2000
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Bacterial Agents
[+]

Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.Jan 08, 2010

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061443
Article Published Date : Jan 08, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Drug Side Effect Attenuation
[+]

Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats. May 01, 2008

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.Apr 01, 2006

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(7):570-3. PMID: 16780161
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin protects against bleomycin-induced damages in pulmonary functions in ratsJun 01, 2008

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1434-8. PMID: 18837350
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin protects bleomycin-induced lung injury in rats.Sep 01, 2008

Pubmed Data : Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 9250724
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Lung Injury: Acute, Oxidative Stress
[+]

Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.Dec 31, 2011

Pubmed Data : Pulm Med. 2012 ;2012:457031. Epub 2012 Aug 8. PMID: 22919480
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Flaxseed
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Problem Substances : Bleomycin
[+]

EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis. Jul 15, 2009

Pubmed Data : Chem Biol Interact. 2009 Jul 15;180(2):271-80. Epub 2009 Mar 20. PMID: 19497426
Article Published Date : Jul 15, 2009
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity.Jul 31, 2013

Pubmed Data : Food Chem Toxicol. 2013 Aug ;58:210-9. Epub 2013 Apr 17. PMID: 23603381
Article Published Date : Jul 31, 2013
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
[+]

Ganoderic acid A inhibits bleomycin-induced lung fibrosis.Dec 31, 2019

Pubmed Data : Pharmacology. 2020 ;105(9-10):568-575. Epub 2020 Jan 15. PMID: 31940650
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Gingko biloba prevents bleomycin-induced oxidative injury in rats. Feb 01, 2006

Pubmed Data : Toxicol Ind Health. 2006 Feb;22(1):47-52. PMID: 16572711
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Antioxidants
Additional Keywords : Antineoplastic Agents, Plant Extracts
[+]

Ginkgo biloba has a positive effect on pulmonary interstitial fibrosis in ratsJun 01, 2000

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun;20(6):441-3. PMID: 11789230
Article Published Date : Jun 01, 2000
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2022 ;16:1793-1809. Epub 2022 Jun 13. PMID: 35719213
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Ginsenoside Rg1 exhibits protective effect against bleomycin-induced pulmonary fibrosis in rats.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2016 ;39(8):1284-92. PMID: 27476938
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
[+]

Hu Zhang (Polygonum cuspidatum), a rich source of resveratrol, inhibits the expression of inflammation in lung fibroblasts and reduces alveolitis and pulmonary fibrosis. Jun 01, 2009

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(12):1574-7. PMID: 19777850
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hu Zhang (Polygonum cuspidatum), Resveratrol
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Hydroxysafflor yellow A attenuates bleomycin-induced pulmonary fibrosis.Mar 31, 2016

Pubmed Data : Phytother Res. 2016 Apr ;30(4):577-87. Epub 2016 Jan 18. PMID: 26777519
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Safflower
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Pubmed Data : J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID: 17289834
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Cystic Fibrosis, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Inhibition of bleomycin-induced pulmonary fibrosis in SD rats by sea cucumber peptides.Mar 29, 2024

Pubmed Data : J Sci Food Agric. 2024 Mar 30 ;104(5):2876-2887. Epub 2023 Dec 12. PMID: 38018265
Article Published Date : Mar 29, 2024
Study Type : Animal Study
Additional Links
Substances : Sea Cucumber
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Beta-Endorphin Enhancer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Juglanin alleviates bleomycin-induced lung injury.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jul ;127:110119. Epub 2020 Apr 7. PMID: 32276127
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Kefir peptides mitigate bleomycin-induced pulmonary fibrosis in mice through modulating oxidative stress, inflammation and gut microbiota.Apr 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2024 May ;174:116431. Epub 2024 Mar 24. PMID: 38522238
Article Published Date : Apr 30, 2024
Study Type : Animal Study
Additional Links
Substances : Kefir
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Chemoprotective Agents
[+]

L-carnitine and ginkgo biloba extract exhibits a protective agent in an animal model of bleomycin-induced lung fibrosis Jun 01, 2002

Pubmed Data : Pharmacol Res. 2002 Jun;45(6):461-7. PMID: 12162946
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Carnitine, Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Lecithinized superoxide dismutase has protective activity against bleomycin-induced pulmonary fibrosis. Dec 24, 2009

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Dec 24. Epub 2009 Dec 24. PMID: 20034962
Article Published Date : Dec 24, 2009
Study Type : Animal Study
Additional Links
Substances : Lecithin, Superoxide dismutase
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Drug Side Effect Attenuation
[+]

Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by ginkgetin.Dec 31, 2022

Pubmed Data : Curr Mol Pharmacol. 2023 ;16(2):217-227. PMID: 35249515
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Olea europaea leaf extract alleviates fibrosis progression and oxidative stress induced by bleomycin.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2023 ;21(3):15593258231200972. Epub 2023 Sep 2. PMID: 37667683
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Antioxidants
[+]

Palmitoylethanolamide reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis.Aug 31, 2016

Pubmed Data : Pharmacol Res. 2016 Sep ;111:405-412. Epub 2016 Jul 8. PMID: 27402190
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Panax notoginseng saponin alleviates pulmonary fibrosis.Jan 09, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2024 Jan 10 ;318(Pt B):116979. Epub 2023 Jul 31. PMID: 37532070
Article Published Date : Jan 09, 2024
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Passion fruit peel extract attenuates bleomycin-induced pulmonary fibrosis.Jul 31, 2014

Pubmed Data : Can J Physiol Pharmacol. 2014 Aug ;92(8):631-9. Epub 2014 Apr 29. PMID: 24933624
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Passion fruit
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Pinocembrin ameliorates skin fibrosis via inhibiting TGF-β1 signaling pathway. Jan 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 08 19 ;11(8). Epub 2021 Aug 19. PMID: 34439906
Article Published Date : Jan 18, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis, Keloid
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation.Dec 31, 2020

Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107230. Epub 2020 Dec 9. PMID: 33290968
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Protective effect of a polyphenols-rich extract from Inonotus Sanghuang on bleomycin-induced acute lung injury.Jul 31, 2019

Pubmed Data : Life Sci. 2019 Aug 1 ;230:208-217. Epub 2019 May 29. PMID: 31152815
Article Published Date : Jul 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Antioxidants, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Protective effects of alpha-lipoic acid on bleomycin-induced skin fibrosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065975. PMID: 35187969
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Transforming growth factor beta (TGF-β) inhibitor
[+]

Resveratrol alleviates chemotherapy-induced (bleomycin) lung injury in rats. Jan 01, 2007

Pubmed Data : : Pulm Pharmacol Ther. 2007;20(6):642-9. Epub 2006 Sep 3. PMID: 17035056
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Adriamycin, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Royal jelly attenuates oxidative damage and fibrosis induced by bleomycin.Jul 20, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Jul 21:1-9. Epub 2016 Jul 21. PMID: 27841941
Article Published Date : Jul 20, 2016
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Problem Substances : Bleomycin
[+]

S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2019 Apr ;139(4):377-384. Epub 2019 Mar 14. PMID: 30928090
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol attenuates bleomycin-induced pulmonary toxicity and fibrosis.Jul 17, 2023

Pubmed Data : J Biochem Mol Toxicol. 2023 Jul 18:e23472. Epub 2023 Jul 18. PMID: 37462223
Article Published Date : Jul 17, 2023
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Sinomenine attenuates bleomycin-induced pulmonary fibrosis, inflammation, and oxidative stress.Mar 31, 2024

Pubmed Data : Inhal Toxicol. 2024 Apr ;36(4):217-227. Epub 2024 May 7. PMID: 38713814
Article Published Date : Mar 31, 2024
Study Type : Animal Study
Additional Links
Substances : Sesame Seeds
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Oxidative Stress, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Tanshinone IIA alleviates bleomycin-induced pulmonary fibrosis by inhibiting Zbtb16.Feb 29, 2024

Pubmed Data : Pulm Pharmacol Ther. 2024 Mar ;84:102285. Epub 2024 Jan 6. PMID: 38191069
Article Published Date : Feb 29, 2024
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Tanshinone IIA ameliorates bleomycin-induced pulmonary fibrosis.Jun 30, 2015

Pubmed Data : J Surg Res. 2015 Jul ;197(1):167-75. Epub 2015 Mar 13. PMID: 25911951
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jun ;11(6):4190-6. Epub 2015 Feb 11. PMID: 25672255
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2014 ;11(6):578-86. Epub 2014 Apr 7. PMID: 24782646
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

The efficacy and safety of pinocembrin in a model of bleomycin-induced pulmonary fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(12):e0260719. Epub 2021 Dec 2. PMID: 34855848
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemosensitizer
[+]

Walnut extract decreases bleomycin induced oxidative stress and lung inflammation.Jul 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Aug 1 ;94:418-429. Epub 2017 Aug 1. PMID: 28778045
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents
[+]

Withaferin A attenuates bleomycin-induced scleroderma.Oct 31, 2018

Pubmed Data : Biofactors. 2018 Nov ;44(6):507-517. Epub 2018 Oct 27. PMID: 30367690
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Scleroderma
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Zingiber officinale-derived extracellular vesicles attenuate bleomycin-induced pulmonary fibrosis.Jul 13, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2023 Jul 14 ;12(14). Epub 2023 Jul 14. PMID: 37508515
Article Published Date : Jul 13, 2023
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
[+]

Andrographolide ameliorates bleomycin-induced pulmonary fibrosis.Mar 14, 2020

Pubmed Data : Toxicol Lett. 2020 Mar 15 ;321:103-113. Epub 2019 Nov 6. PMID: 31706003
Article Published Date : Mar 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Andrographis
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Transforming growth factor beta (TGF-β) inhibitor
[+]

Astilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway.Dec 31, 2017

Pubmed Data : Pulm Pharmacol Ther. 2018 06 ;50:19-27. Epub 2018 Apr 3. PMID: 29621624
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Astragaloside IV inhibits bleomycin-induced ferroptosis in human umbilical vein endothelial cells by mediating LPC.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:6241242. Epub 2021 Nov 1. PMID: 34760046
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
[+]

Component analysis and anti-pulmonary fibrosis effects of Rosa sterilis juice.Dec 12, 2022

Pubmed Data : Food Funct. 2022 Dec 13 ;13(24):12915-12924. Epub 2022 Dec 13. PMID: 36444933
Article Published Date : Dec 12, 2022
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Polyphenols, Rose
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells.Jun 13, 2022

Pubmed Data : Drug Chem Toxicol. 2022 Jun 14:1-10. Epub 2022 Jun 14. PMID: 35702048
Article Published Date : Jun 13, 2022
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Chemotherapy-Induced Toxicity: Oxaliplatin
Pharmacological Actions : Chemoprotective Agents, Genoprotective
[+]

Naringin dose dependently decreased the total chromosome aberrations frequency induced by bleomycin.May 04, 2015

Pubmed Data : Drug Chem Toxicol. 2015 May 5:1-5. Epub 2015 May 5. PMID: 25941869
Article Published Date : May 04, 2015
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, DNA damage
Pharmacological Actions : Genoprotective
Additional Keywords : Dose Response
[+]

Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosisMay 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2016 Jun ;37(6):794-804. Epub 2016 May 2. PMID: 27133302
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Anti-Fibrotic
[+]

Piceatannol could protect against oxidative injury and collagen synthesis during pulmonary fibrosis.Sep 30, 2022

Pubmed Data : Int Immunopharmacol. 2022 Oct ;111:109107. Epub 2022 Aug 3. PMID: 35932616
Article Published Date : Sep 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants
[+]

Quercetin could alleviate pulmonary fibrosis and improve epithelial-mesenchymal transition by acting on the SIRT1/AMPK signaling pathway.Jul 12, 2024

Pubmed Data : Mol Biol Rep. 2024 Jul 13 ;51(1):795. Epub 2024 Jul 13. PMID: 39001907
Article Published Date : Jul 12, 2024
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Sinomenine attenuates pulmonary fibrosis.May 09, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pulm Med. 2024 May 10 ;24(1):229. Epub 2024 May 10. PMID: 38730387
Article Published Date : May 09, 2024
Study Type : In Vitro Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

The combination of bleomycin and honokiol suggests that they can be used as combination therapy for treatment of cancer.Feb 19, 2017

Pubmed Data : Chem Res Toxicol. 2017 Feb 20 ;30(2):715-725. Epub 2017 Jan 19. PMID: 28067485
Article Published Date : Feb 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Bleomycin, Lung Cancer, Pancreatic Cancer, Skin Cancer
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

These studies investigate micronuclei formation at different specific absorption rates, in conjunction with bleomycin, for 18 hours.Nov 10, 2003

Pubmed Data : Mutat Res. 2003 Nov 10 ;541(1-2):81-9. PMID: 14568297
Article Published Date : Nov 10, 2003
Study Type : In Vitro Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, DNA damage
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Cytotoxic, Genotoxic
[+]

Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis.Dec 31, 2023

Pubmed Data : Life Sci. 2024 Jan 1 ;336:122272. Epub 2023 Nov 18. PMID: 37981228
Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Fenugreek
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

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