Chemotherapy-Induced Toxicity: Irinotecan

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12 Substances Researched for Chemotherapy-Induced Toxicity: Irinotecan

Name	AC	CK
Alpha-Lipoic Acid	1	2
Berberine	1	2
Bifidobacterium Longum	1	2
Curcumin	1	2
EGCG (Epigallocatechin gallate)	1	2
Green Tea	1	2
Luteolin	1	2
Polyphenols	1	2
Salvia miltiorrhiza	1	2
Selenium	1	2
Silymarin	1	2
Bee Propolis	1	1

1 Problem Substances Researched for Chemotherapy-Induced Toxicity: Irinotecan

Name	AC	CK	Focus
Irinotecan	6	12

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD

View the Evidence:
11 Abstracts with Chemotherapy-Induced Toxicity: Irinotecan Research

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Berberine improves irinotecan-induced intestinal mucositis without impairing the anti-colorectal cancer efficacy of irinotecan.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:774560. Epub 2021 Nov 2. PMID: 34795594

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Chemoprotective Agents, Gastrointestinal Agents, Gastroprotective

[+]

Cryptotanshinone alleviates chemotherapy-induced colitis in mice with colon cancer.Dec 31, 2020

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Pubmed Data : Pharmacol Res. 2021 01 ;163:105232. Epub 2020 Oct 4. PMID: 33027716

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil , Chemotherapy-Induced Toxicity: Irinotecan, Colitis, Colon Cancer

Pharmacological Actions : Chemoprotective Agents, Gastrointestinal Agents, Hypolipidemic

[+]

Curcumin protects against testis-specific side effects of irinotecan.Nov 30, 2021

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2021 Dec ;25(23):7440-7448. PMID: 34919246

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents

Problem Substances : Irinotecan

[+]

Green teaGreen tea polyphenol administration partly ameliorates irinotecan chemotherapy-induced side effects in the small intestine of mice.Mar 01, 2007

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Pubmed Data : J Nutr. 2007 Mar;137(3):634-40. PMID: 17311952

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Green Tea, Polyphenols

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Antineoplastic Agents

[+]

Investigation of the possible protective effect of N-Acetylcysteine (NAC) against irinotecan (CPT-11)-induced toxicity.Nov 09, 2022

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Pubmed Data : Antioxidants (Basel). 2022 Nov 10 ;11(11). Epub 2022 Nov 10. PMID: 36421407

Article Published Date : Nov 09, 2022

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents

Problem Substances : Irinotecan

[+]

Luteolin prevents intestinal mucositis induced by irinotecan.Jan 23, 2020

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Pubmed Data : Br J Pharmacol. 2020 Jan 24. Epub 2020 Jan 24. PMID: 31976547

Article Published Date : Jan 23, 2020

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Drug-Induced Toxicity: Gastrointestinal, Mucositis

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Gastroprotective, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Irinotecan

[+]

Selenium-enriched Bifidobacterium longum DD98 attenuates irinotecan-induced intestinal and hepatic toxicity in vitro and in vivo.Oct 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Nov ;143:112192. Epub 2021 Sep 25. PMID: 34649340

Article Published Date : Oct 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bifidobacterium Longum , Selenium

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Irinotecan

[+]

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

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Pubmed Data : Toxicol Appl Pharmacol. 2017 Apr 25. Epub 2017 Apr 25. PMID: 28454924

Article Published Date : Apr 24, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Irinotecan

[+]

The alpha-lipoic acid improves survival and prevents irinotecan-induced inflammation and intestinal dysmotility.Nov 02, 2020

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Pubmed Data : Pharmaceuticals (Basel). 2020 Nov 3 ;13(11). Epub 2020 Nov 3. PMID: 33152996

Article Published Date : Nov 02, 2020

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Anti-Inflammatory Agents, Antidiarrheals, Chemoprotective Agents, Gastroprotective

[+]

Total flavonoids of glycyrrhiza uralensis alleviates irinotecan-induced colitis.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021 ;12:628358. Epub 2021 May 7. PMID: 34025639

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Colitis

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective

Problem Substances : Irinotecan

[+]

Propolis reduces irinotecan-induced toxic and genotoxic effects to normal cells without effecting irinotecan cytotoxicity in Ehrlich ascites tumor cells.Dec 16, 2009

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Pubmed Data : Med Oncol. 2009 Dec 16. Epub 2009 Dec 16. PMID: 20013318

Article Published Date : Dec 16, 2009

Study Type : In Vitro Study

Additional Links

Substances : Bee Propolis

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Additional Keywords : Selective Cytotoxicity

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 11 Abstracts with Chemotherapy-Induced Toxicity: Irinotecan Research

Limited to Members Only

Currently Available Sorting Options

Berberine improves irinotecan-induced intestinal mucositis without impairing the anti-colorectal cancer efficacy of irinotecan.Dec 31, 2020

Cryptotanshinone alleviates chemotherapy-induced colitis in mice with colon cancer.Dec 31, 2020

Curcumin protects against testis-specific side effects of irinotecan.Nov 30, 2021

Green teaGreen tea polyphenol administration partly ameliorates irinotecan chemotherapy-induced side effects in the small intestine of mice.Mar 01, 2007

Investigation of the possible protective effect of N-Acetylcysteine (NAC) against irinotecan (CPT-11)-induced toxicity.Nov 09, 2022

Luteolin prevents intestinal mucositis induced by irinotecan.Jan 23, 2020

Selenium-enriched Bifidobacterium longum DD98 attenuates irinotecan-induced intestinal and hepatic toxicity in vitro and in vivo.Oct 31, 2021

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

The alpha-lipoic acid improves survival and prevents irinotecan-induced inflammation and intestinal dysmotility.Nov 02, 2020

Total flavonoids of glycyrrhiza uralensis alleviates irinotecan-induced colitis.Dec 31, 2020

Propolis reduces irinotecan-induced toxic and genotoxic effects to normal cells without effecting irinotecan cytotoxicity in Ehrlich ascites tumor cells.Dec 16, 2009

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Chemotherapy-Induced Toxicity: Irinotecan

View the Evidence:
11 Abstracts with Chemotherapy-Induced Toxicity: Irinotecan Research