Chemotherapy-Induced Toxicity: Tamoxifen

Name	AC	CK
Curcumin	2	3
Bamboo	1	2
Bee Propolis	1	2
Grape Seed Extract	1	2
Luteolin	1	2
Nigella sativa (aka Black Seed)	1	2
Propolis: Bee	1	2
Rose	1	2
Vitamin E	1	2
Zinc	1	2
Honey	1	1
Thymoquinone	1	1
Tualang Honey	1	1
Vanillin	1	1

Name	AC	CK	Focus
Tamoxifen	14	60

[+]

Tamoxifen was a risk factor for chemotherapy-induced amenorrhea.May 31, 2016

Click here to read the entire abstract

Pubmed Data : Acta Oncol. 2016 Jun ;55(6):664-70. Epub 2016 Apr 22. PMID: 27105082

Article Published Date : May 31, 2016

Study Type : Meta Analysis, Review

Additional Links

Diseases : Amenorrhoea, Chemotherapy-Induced Toxicity: Tamoxifen

Additional Keywords : Risk Factors

Problem Substances : Tamoxifen

[+]

Correlation of the tamoxifen use with the increased risk of deep vein thrombosis and pulmonary embolism in elderly women with breast cancer.Nov 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2018 Dec ;97(51):e12842. PMID: 30572423

Article Published Date : Nov 30, 2018

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Deep Vein Thrombosis, Pulmonary Embolism

Additional Keywords : Increased Risk

Problem Substances : Tamoxifen

[+]

Tamoxifen and toremifene treatment is significantly associated with reversible NAFLD in Asian women.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Breast. 2016 Aug ;28:67-72. Epub 2016 May 27. PMID: 27240168

Article Published Date : Jul 31, 2016

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Tamoxifen, Fatty Liver, Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Risk Factors

Problem Substances : Tamoxifen

[+]

Acute pancreatitis caused by tamoxifen-induced severe hypertriglyceridemia after 4 years of tamoxifen use.Jan 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ACG Case Rep J. 2019 Feb ;6(2):1-3. Epub 2019 Mar 7. PMID: 31157284

Article Published Date : Jan 31, 2019

Study Type : Human: Case Report

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Pancreatitis, Triglycerides: Elevated

Additional Keywords : Risk Factors

Problem Substances : Tamoxifen

[+]

Effects on lipid profile must be considered while initiating tamoxifen in predisposed individuals as the consequences are life threatening.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Pharmacother. 2016 Jan-Mar;7(1):38-40. PMID: 27127396

Article Published Date : Dec 31, 2015

Study Type : Human: Case Report

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Dyslipidemias

[+]

Tamoxifen-induced acute eosinophilic pneumonia in a breast cancer patient.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Surg Case Rep. 2019 ;60:186-190. Epub 2019 Feb 27. PMID: 31229774

Article Published Date : Dec 31, 2018

Study Type : Human: Case Report

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Pneumonia: Drug-Induced, Pneumonia: Eosinophilic

Additional Keywords : Risk Factors

Problem Substances : Tamoxifen

[+]

The present study describes a case of radiation recall dermatitis that occurred 6 years and 4 months after breast-conserving surgery.Apr 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 May ;11(5):3071-3074. Epub 2016 Mar 17. PMID: 27123065

Article Published Date : Apr 30, 2016

Study Type : Human: Case Report

Additional Links

Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Tamoxifen

Additional Keywords : Risk Factors

[+]

Bamboo concentrate enhances the bioavailability of the chemotherapy agent paclitaxel. Nov 01, 2010

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Pubmed Data : Radiat Res. 2010 Nov;174(5):624-36. Epub 2010 Sep 13. PMID: 15918522

Article Published Date : Nov 01, 2010

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Ethanol-extracted cameroonian propolis counteracts tamoxifen-induced endometrial hyperplasia.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:2684742. Epub 2022 Apr 13. PMID: 39280959

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Propolis: Bee

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Cancer

Pharmacological Actions : Chemoprotective Agents

[+]

Grape seed extract, black seed extract and curcumin ameliorate tamoxifen-induced liver injury.Jan 01, 2007

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Pubmed Data : Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 21046982

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Grape Seed Extract, Nigella sativa (aka Black Seed)

Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Tamoxifen, Drug-Induced Toxicity

Pharmacological Actions : Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Drug: Tamoxifen, Plant Extracts

[+]

Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system.Aug 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 Aug 21 ;7(1):8991. Epub 2017 Aug 21. PMID: 28827578

Article Published Date : Aug 20, 2017

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Infertility: Male

Problem Substances : Tamoxifen

[+]

Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment.Jul 11, 2021

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2021 Jul 12 ;908:174337. Epub 2021 Jul 12. PMID: 34265292

Article Published Date : Jul 11, 2021

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Neuroprotective Agents

[+]

Propolis contains a compound, caffeic acid phenethyl ester, which protects against Tamoxifen-induced liver toxicity. Nov 20, 2006

Click here to read the entire abstract

Pubmed Data : Brain Res. 2006 Nov 20;1120(1):183-90. Epub 2006 Sep 20. PMID: 19394397

Article Published Date : Nov 20, 2006

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Rosa canina distilled water could modulate tamoxifen-induced fatty liver as well as improving the sperm parameters.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Pak J Biol Sci. 2020 Jan ;23(2):173-180. PMID: 31944077

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

[+]

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.Jun 26, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lab Anim. 2019 Jun 27:23677219856918. Epub 2019 Jun 27. PMID: 31248325

Article Published Date : Jun 26, 2019

Study Type : Animal Study

Additional Links

Diseases : Abortion: Induced, Chemotherapy-Induced Toxicity: Tamoxifen, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Tamoxifen

[+]

Tamoxifen stresses cells of the adult central and peripheral nervous systems and highlights concerns about its clinical and experimental use.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Neuropathol Commun. 2015 ;3(1):74. Epub 2015 Nov 26. PMID: 26610346

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Risk Factors

Problem Substances : Tamoxifen

[+]

Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation.Sep 30, 2019

Click here to read the entire abstract

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1 ;317(4):G518-G530. Epub 2019 Aug 1. PMID: 31369292

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Gastrointestinal Inflammation

Problem Substances : Tamoxifen

[+]

Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity.Sep 30, 2019

Click here to read the entire abstract

Pubmed Data : Toxicol Mech Methods. 2019 Oct 1:1-9. Epub 2019 Oct 1. PMID: 31532279

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Zinc

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective

Problem Substances : Tamoxifen

[+]

Curcurmin potentiates the cytotoxic effects of tamoxifen on K562 cells and also decreases the associated cytotoxicity on red blood cells and polymorphonuclear leukocytes.Jul 31, 2013

Click here to read the entire abstract

Pubmed Data : J Enzyme Inhib Med Chem. 2013 Aug ;28(4):734-40. Epub 2012 Apr 23. PMID: 22524678

Article Published Date : Jul 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Vanillin

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Insights into the protective effects of thymoquinone against toxicities induced by chemotherapeutic agents.Dec 29, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Dec 30 ;27(1). Epub 2021 Dec 30. PMID: 35011457

Article Published Date : Dec 29, 2021

Study Type : Review

Additional Links

Substances : Thymoquinone

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Doxorubicin, Chemotherapy-Induced Toxicity: Tamoxifen, Drug Toxicity: Methotrexate

Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Hepatoprotective, Renoprotective

[+]

Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Theranostics. 2017 ;7(7):1890-1900. Epub 2017 Apr 10. PMID: 28638475

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Neoplasms

Problem Substances : Tamoxifen

[+]

Tamoxifen has a proliferative effect in endometrial carcinoma cells.Dec 04, 2016

Click here to read the entire abstract

Pubmed Data : Mol Cell Endocrinol. 2016 Dec 5 ;437:51-61. Epub 2016 Aug 9. PMID: 27519631

Article Published Date : Dec 04, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Cancer

Additional Keywords : Increased Risk

Problem Substances : Tamoxifen

[+]

Tamoxifen-dependent induction of AGR2 is associated with increased aggressiveness of endometrial cancer cells.Apr 11, 2017

Click here to read the entire abstract

Pubmed Data : Cancer Invest. 2017 Apr 12:1-12. Epub 2017 Apr 12. PMID: 28402678

Article Published Date : Apr 11, 2017

Study Type : In Vitro Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Cancer

Additional Keywords : Increased Risk

Problem Substances : Tamoxifen

[+]

Tualang honey enhances tamoxifen induced cytotoxicity and DNA damage in breast cancer cells while affording protection to the non-cancerous cells.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2014 ;14:106. Epub 2014 Mar 19. PMID: 24646375

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Honey

Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Chemoprotective Agents, DNA Repair Up-regulation, Genoprotective

Additional Keywords : Synergy with Tamoxifen

[+]

Tualang honey may be a potential adjuvant to be used with TAM for reducing the dose of TAM and reducing TAM-induced adverse effects.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:989841. Epub 2013 Feb 13. PMID: 23476711

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Tualang Honey

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Apoptotic, Chemoprotective Agents

Problem Substances : Tamoxifen

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View the Evidence: 25 Abstracts with Chemotherapy-Induced Toxicity: Tamoxifen Research

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Tamoxifen was a risk factor for chemotherapy-induced amenorrhea.May 31, 2016

Correlation of the tamoxifen use with the increased risk of deep vein thrombosis and pulmonary embolism in elderly women with breast cancer.Nov 30, 2018

Tamoxifen and toremifene treatment is significantly associated with reversible NAFLD in Asian women.Jul 31, 2016

Acute pancreatitis caused by tamoxifen-induced severe hypertriglyceridemia after 4 years of tamoxifen use.Jan 31, 2019

Effects on lipid profile must be considered while initiating tamoxifen in predisposed individuals as the consequences are life threatening.Dec 31, 2015

Tamoxifen-induced acute eosinophilic pneumonia in a breast cancer patient.Dec 31, 2018

The present study describes a case of radiation recall dermatitis that occurred 6 years and 4 months after breast-conserving surgery.Apr 30, 2016

Bamboo concentrate enhances the bioavailability of the chemotherapy agent paclitaxel. Nov 01, 2010

Ethanol-extracted cameroonian propolis counteracts tamoxifen-induced endometrial hyperplasia.Dec 31, 2021

Grape seed extract, black seed extract and curcumin ameliorate tamoxifen-induced liver injury.Jan 01, 2007

Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system.Aug 20, 2017

Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment.Jul 11, 2021

Propolis contains a compound, caffeic acid phenethyl ester, which protects against Tamoxifen-induced liver toxicity. Nov 20, 2006

Rosa canina distilled water could modulate tamoxifen-induced fatty liver as well as improving the sperm parameters.Dec 31, 2019

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.Jun 26, 2019

Tamoxifen stresses cells of the adult central and peripheral nervous systems and highlights concerns about its clinical and experimental use.Dec 31, 2014

Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation.Sep 30, 2019

Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity.Sep 30, 2019

Curcurmin potentiates the cytotoxic effects of tamoxifen on K562 cells and also decreases the associated cytotoxicity on red blood cells and polymorphonuclear leukocytes.Jul 31, 2013

Insights into the protective effects of thymoquinone against toxicities induced by chemotherapeutic agents.Dec 29, 2021

Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.Dec 31, 2016

Tamoxifen has a proliferative effect in endometrial carcinoma cells.Dec 04, 2016

Tamoxifen-dependent induction of AGR2 is associated with increased aggressiveness of endometrial cancer cells.Apr 11, 2017

Tualang honey enhances tamoxifen induced cytotoxicity and DNA damage in breast cancer cells while affording protection to the non-cancerous cells.Dec 31, 2013

Tualang honey may be a potential adjuvant to be used with TAM for reducing the dose of TAM and reducing TAM-induced adverse effects.Dec 31, 2012

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Chemotherapy-Induced Toxicity: Tamoxifen

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25 Abstracts with Chemotherapy-Induced Toxicity: Tamoxifen Research