Chronic Myeloid Leukemia

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42 Substances Researched for Chronic Myeloid Leukemia
NameACCKFocus
Curcumin55Locked
Tualang Honey15Locked
Naringenin 13Locked
Shikonin33Locked
Thymoquinone33Locked
Vitamin D23Locked
Agaricus Blazei22Locked
Berberine12Locked
Gallic Acid22Locked
Lemon12Locked
Piperine22Locked
Rosemary12Locked
Tomato12Locked
Ashwagandha11Locked
Betulinic acid11Locked
Carnosic Acid11Locked
Curcumol11Locked
Cysteine (see N-Acetylcysteine)11Locked
Diosgenin11Locked
EGCG (Epigallocatechin gallate)11Locked
Emodin11Locked
Fisetin11Locked
Flavonoids11Locked
Gold (nanoparticles)11Locked
Indigo Naturalis11Locked
Leonurine11Locked
Lotus 11Locked
Mugwort11Locked
Myricetin11Locked
Nobiletin 11Locked
Olive leaf extract11Locked
Panax Notoginseng11Locked
Parthenolide11Locked
Pomegranate Peel11Locked
Procyanidin B2 11Locked
Pterostilbene11Locked
Quercetin11Locked
Resveratrol11Locked
Salvia miltiorrhiza11Locked
Tanshinone IIA11Locked
Verbascoside11Locked
Vitamin C11Locked
5 Problem Substances Researched for Chronic Myeloid Leukemia
NameACCKFocus
Benzene321Locked
Crude Oil/Petroleum110Locked
Pesticides110Locked
Benzene Metabolites11Locked
Hydroquinone11Locked
3 Problematic Actions Researched for Chronic Myeloid Leukemia
NameACCKFocus
Electromagnetic Field Harms110Locked
Electromagnetic Radiation110Locked
Microwave Radiation110Locked
Related Topics

Chronic Myeloid Leukemia is a Sub of the following Topics

View the Evidence:
53 Abstracts with Chronic Myeloid Leukemia Research

[+]

Myeloid leukemia was associated with benzene, a nonspecific group of solvents, occupational pesticides, and working with or near powerlines.Nov 01, 2009

Pubmed Data : Ann Hematol. 2009 Nov ;88(11):1079-88. Epub 2009 Mar 18. PMID: 19294385
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Leukemia
Additional Keywords : EMF, RF-EMF and Cancers
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Microwave Radiation
Problem Substances : Benzene, Pesticides
[+]

Workers exposed to petroleum products may have increased risk for certain leukemias, in part due to benzene exposure.Mar 01, 1997

Pubmed Data : Occup Environ Med. 1997 Mar;54(3):152-66. PMID: 9155776
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Monocytic
Problem Substances : Benzene, Crude Oil/Petroleum
[+]

Tualang honey produced a significant apoptosis effect on both acute and chronic leukemia cell lines.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:307094. Epub 2015 Nov 3. PMID: 26613081
Article Published Date : Dec 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Tualang Honey
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Oxidative lipid damage by naringenin selectively sensitizes chronic myeloid leukemia cell lines.Sep 02, 2024

Pubmed Data : Biochem Biophys Res Commun. 2024 Sep 3 ;733:150653. Epub 2024 Sep 3. PMID: 39278089
Article Published Date : Sep 02, 2024
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death.Aug 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Aug 14 ;6(23):19514-27. PMID: 26098775
Article Published Date : Aug 13, 2015
Study Type : Animal Study
Additional Links
Substances : Lemon
Diseases : Chronic Myeloid Leukemia, Colon Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Results from the present study indicated that α tomatine may have useful anti leukemia activities.May 31, 2015

Pubmed Data : Mol Med Rep. 2015 Jun ;11(6):4573-8. Epub 2015 Jan 22. PMID: 25625536
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tomato
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

The use of berberine is a new strategy to improve the treatment of chronic myeloid leukemia patients with imatinib sensitivity or resistance.Feb 24, 2020

Pubmed Data : Clin Cancer Res. 2020 Feb 25. Epub 2020 Feb 25. PMID: 32098768
Article Published Date : Feb 24, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Vitamin D3 and rosemary have a cooperative antitumor effect in a mouse model of myeloid leukemia. Jun 15, 2006

Pubmed Data : Int J Cancer. 2006 Jun 15;118(12):3012-21. PMID: 16395705
Article Published Date : Jun 15, 2006
Study Type : Animal Study
Additional Links
Substances : Rosemary, Vitamin D
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia
Pharmacological Actions : Anti-Tumor, Anticarcinogenic Agents
Additional Keywords : Antineoplastic Agents, Natural Substance Synergy, Plant Extracts
[+]

Agaricus blazei extract (FA-2-b-β) induces apoptosis in chronic myeloid leukemia cells.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2020 Nov ;20(5):270. Epub 2020 Sep 21. PMID: 32989404
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Agaricus Blazei
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Agaricus blazei extract inhibits human myeloid leukemia cells.Mar 18, 2009

Pubmed Data : J Ethnopharmacol. 2009 Mar 18;122(2):320-6. Epub 2008 Dec 27. PMID: 19162153
Article Published Date : Mar 18, 2009
Study Type : In Vitro Study
Additional Links
Substances : Agaricus Blazei
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia
[+]

Anti-leukemic effects of gallic acid on human leukemia K562 cells.Mar 31, 2012

Pubmed Data : Toxicol In Vitro. 2012 Apr ;26(3):396-405. Epub 2012 Jan 8. PMID: 22245431
Article Published Date : Mar 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Artemisia vulgaris inhibits BCR/ABL and promotes apoptosis in chronic myeloid leukemia cells.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Rep. 2022 Dec ;17(6):92. Epub 2022 Oct 5. PMID: 36382259
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Mugwort
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Ashwaganda induces programmed cell death in human myeloid leukemia cells.Nov 01, 2007

Pubmed Data : Apoptosis. 2007 Nov;12(11):2115-33. PMID: 17874299
Article Published Date : Nov 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Ashwagandha
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Myeloid Leukemia: Acute
[+]

Benzene and its metabolites are leukemogenic.May 01, 2010

Pubmed Data : Leukemia. 2010 May;24(5):986-91. Epub 2010 Mar 25. PMID: 20339439
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene, Benzene Metabolites, Hydroquinone
[+]

Betulinic acid restores imatinib sensitivity in BCR-ABL1 kinase-independent, imatinib-resistant chronic myeloid leukemia.Jan 12, 2020

Pubmed Data : Ann N Y Acad Sci. 2020 Jan 13. Epub 2020 Jan 13. PMID: 31930541
Article Published Date : Jan 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Cancer glycolytic dependence as a new target of olive leaf extract.Jan 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013090
Article Published Date : Jan 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Olive leaf extract
Diseases : Breast Cancer, Cancers: All, Chronic Myeloid Leukemia, Colon Cancer, Melanoma
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Cancer Glycolysis
[+]

Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells.Apr 30, 2018

Pubmed Data : J BUON. 2018 May-Jun;23(3):741-746. PMID: 30003745
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator
[+]

Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):893-903. PMID: 34214017
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Chemotherapeutic, STAT3 Inhibitor
[+]

Curcumin has anti-cancer activity against drug-resistant chronic myeloid leukemia cells.Jul 01, 2006

Pubmed Data : Mol Cancer Res. 2006 Jul;4(7):457-69. PMID: 16849521
Article Published Date : Jul 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Curcumin induces programmed cell death in chronic myeloid leukemia cells. Nov 01, 2009

Pubmed Data : J Asian Nat Prod Res. 2009 Nov;11(11):918-28. PMID: 20183254
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Curcumin is an inhibitor of cancer.Apr 01, 1992

Pubmed Data : J Am Coll Nutr. 1992 Apr;11(2):192-8. PMID: 1578097
Article Published Date : Apr 01, 1992
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chronic Myeloid Leukemia, Gastric Cancer, Skin Cancer
Pharmacological Actions : Chemopreventive
[+]

Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.Oct 01, 2010

Pubmed Data : J Pharmacol Exp Ther. 2010 Oct;335(1):114-23. Epub 2010 Jul 6. PMID: 20605902
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer
Additional Keywords : Drug: Arsenic Trioxide, Drug: Lonidamine, Drug Synergy
[+]

Curcumol and FTY720 synergistically induce apoptosis and differentiation in chronic myelomonocytic leukemia via multiple signaling pathways.Mar 31, 2021

Pubmed Data : Phytother Res. 2021 Apr ;35(4):2157-2170. Epub 2020 Dec 4. PMID: 33274566
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells.Mar 14, 2016

Pubmed Data : Phytomedicine. 2016 Mar 15 ;23(3):243-52. Epub 2016 Feb 9. PMID: 26969378
Article Published Date : Mar 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

EGCG induced cell death via the cGMP/ASM pathway in chronic myeloid leukemia cells.Jun 25, 2015

Pubmed Data : Oncol Rep. 2015 Jun 26. Epub 2015 Jun 26. PMID: 26135316
Article Published Date : Jun 25, 2015
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Emodin inhibits resistance to imatinib in chronic myeloid leukemia cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2020 ;43(10):1526-1533. PMID: 32999163
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
[+]

Gallic acid enhances the efficacy of BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia.Jul 20, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2024 Jul 21 ;25(14). Epub 2024 Jul 21. PMID: 39063200
Article Published Date : Jul 20, 2024
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Indirubin, an active component of Indigo Naturalis, exhibits inhibitory effects on leukemia cells.Feb 11, 2024

Pubmed Data : Anticancer Agents Med Chem. 2024 Feb 12. Epub 2024 Feb 12. PMID: 38347773
Article Published Date : Feb 11, 2024
Study Type : In Vitro Study
Additional Links
Substances : Indigo Naturalis
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Leonurine exerts significant anti-leukemia efficacy in chronic myeloid leukemia.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:657724. Epub 2021 Apr 16. PMID: 33935775
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Leonurine
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Mechanism of procyanidin B2 in the treatment of chronic myeloid leukemia.Dec 31, 2022

Pubmed Data : Anticancer Agents Med Chem. 2023 ;23(16):1838-1847. PMID: 37246327
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Procyanidin B2
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Gene Expression Regulation
[+]

Myricetin is effective and selective in inhibiting imatinib-resistant chronic myeloid leukemia stem and differentiated cells through targeting eIF4E.Nov 17, 2022

Pubmed Data : Anticancer Drugs. 2022 Nov 18. Epub 2022 Nov 18. PMID: 36730418
Article Published Date : Nov 17, 2022
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

N-acetylcysteine and ascorbic acid might inhibit hemin-induced K562 cell erythroid differentiation by downregulating ROS levels.Feb 28, 2018

Pubmed Data : Biomed Environ Sci. 2018 Mar ;31(3):247-251. PMID: 29673449
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine), Vitamin C
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Chemotherapeutic
[+]

Neferine might be a promising natural compound to potentiate imatinib in CML patients.Mar 31, 2019

Pubmed Data : J Food Sci. 2019 Apr ;84(4):904-910. Epub 2019 Mar 13. PMID: 30866043
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Nobiletin may serve as a beneficial anti-leukemic agent for differentiation therapy.Apr 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 Apr 3 ;9(4). Epub 2020 Apr 3. PMID: 32260160
Article Published Date : Apr 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Chronic Myeloid Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Panax notoginseng saponins can inhibit the proliferation and induce apoptosis in K562 cells.Jul 31, 2015

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2015 Aug ;35(8):1103-9. PMID: 26277504
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Panax Notoginseng
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Parthenolide induced cell death in primitive chronic myeloid leukaemia cells through reactive oxygen species.Aug 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2018 Aug 5. Epub 2018 Aug 5. PMID: 30079458
Article Published Date : Aug 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Pegylated gold nanoparticles induce apoptosis in human chronic myeloid leukemia cells.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:182353. Epub 2014 Mar 25. PMID: 24790990
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Pomegranate peel extract inhibited the cell proliferation of chronic myeloid leukemia cells.Apr 30, 2015

Pubmed Data : Int J Appl Basic Med Res. 2015 May-Aug;5(2):100-105. PMID: 26097816
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells.Jan 12, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Jan 13 ;12(1):704. Epub 2022 Jan 13. PMID: 35027628
Article Published Date : Jan 12, 2022
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Quercetin promotes cell cycle arrest and apoptosis and attenuates the proliferation of human chronic myeloid leukemia cell.Jul 28, 2019

Pubmed Data : Anticancer Agents Med Chem. 2019 Jul 29. Epub 2019 Jul 29. PMID: 31362681
Article Published Date : Jul 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Resveratrol induces programmed cell death in human chronic myeloid and acute lymphoblastic leukemia cells. Nov 15, 2004

Pubmed Data : Biochem Pharmacol. 2004 Nov 15;68(10):2019-30. PMID: 15476673
Article Published Date : Nov 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Acute lymphoblastic leukemia (ALL), Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Selective cytotoxicity of piperine over multidrug resistance leukemic cells. Feb 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Feb 10 ;26(4). Epub 2021 Feb 10. PMID: 33578817
Article Published Date : Feb 09, 2021
Study Type : In Vitro Study
Additional Links
Substances : Piperine
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators
Additional Keywords : Selective Cytotoxicity
[+]

Shikonin overcomes drug resistance and induces necroptosis by regulating the miR-92a-1-5p/MLKL axis in chronic myeloid leukemia.Sep 13, 2020

Pubmed Data : Aging (Albany NY). 2020 Sep 14 ;12(17):17662-17680. Epub 2020 Sep 14. PMID: 32927433
Article Published Date : Sep 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Chemosensitizer, MicroRNA modulator
[+]

Shikonin overcomes drug resistance and induces necroptosis by regulating the miR-92a-1-5p/MLKL axis in chronic myeloid leukemia.Sep 13, 2020

Pubmed Data : Aging (Albany NY). 2020 Sep 14 ;12(17):17662-17680. Epub 2020 Sep 14. PMID: 32927433
Article Published Date : Sep 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Chemosensitizer, MicroRNA modulator
[+]

The anticancer activity of tanshinone IIA and cryptotanshinone is mediated by the distinct the JAK/STAT3/5 and SHP1/2 signalling.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:805639. Epub 2013 Jun 26. PMID: 23878608
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

The present study reveals that piperine and curcumin exhibit significant antitumor activity in human leukemia HL60 cells.Dec 31, 2019

Pubmed Data : J BUON. 2020 Jan-Feb;25(1):401-406. PMID: 32277661
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Piperine
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

These results demonstrated that shikonin inhibits chronic myeloid leukemia proliferation and migration and induces apoptosis.May 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 May 24 ;47(3):981-993. Epub 2018 May 24. PMID: 29843123
Article Published Date : May 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

These results suggest that fisetin and hesperetin could be potential natural agents for Chronic myeloid leukemia therapy.Sep 24, 2015

Pubmed Data : Tumour Biol. 2015 Sep 25. Epub 2015 Sep 25. PMID: 26408178
Article Published Date : Sep 24, 2015
Study Type : In Vitro Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Chemotherapeutic
Additional Keywords : Gene Expression Regulation
[+]

Thymoquinone enhances apoptosis of K562 chronic myeloid leukemia cells.Jun 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2023 Jun 15 ;16(6). Epub 2023 Jun 15. PMID: 37375831
Article Published Date : Jun 14, 2023
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Thymoquinone induces downregulation of BCR-ABL/JAK/STAT pathway and apoptosis in K562 leukemia cells.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2021 Dec 1 ;22(12):3959-3965. Epub 2021 Dec 1. PMID: 34967577
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic
[+]

Thymoquinone inhibits JAK/STAT and PI3K/Akt/ mTOR signaling pathways in MV4-11 and K562 myeloid leukemia cells.Sep 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Sep 8 ;15(9). Epub 2022 Sep 8. PMID: 36145344
Article Published Date : Sep 07, 2022
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia
[+]

Verbascoside potentiates the effect of tyrosine kinase inhibitors in chronic myeloid leukaemia.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2022 Aug ;24(2):514. Epub 2022 Jun 14. PMID: 35837042
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Verbascoside
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic, Chemotherapeutic
[+]

Vitamin D may induce programmed cell death in chronic myeloid leukemia cells by modulating apoptosis-related genes. May 28, 2009

Pubmed Data : 1: Ann Hematol. 2009 May 28. PMID:19475409
Article Published Date : May 28, 2009
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Apoptotic

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