Circadian Dysregulation

Name	AC	CK
Melatonin	10	50
Probiotics	2	12
Yoghurt	1	10
Grape Seed Extract	2	4
Nobiletin	2	4
Proanthocyanidins	2	4
Tea: Oolong	2	4
Alpha-Lipoic Acid	1	2
Apple Polyphenols	1	2
Pterostilbene	1	2
Resveratrol	1	2
Turmeric	1	2

Name	AC	CK
Artificial Sweeteners	1	2
Fluoxetine (trade name Prozac)	1	2
Polystyrene nanoparticles	1	2
Saccharin	1	2
Cell Phone Exposure	1	1
Pesticides	1	1

Name	AC	CK
Amber Lenses	1	10
Light Therapy	1	10
Sunlight exposure	1	10

Name	AC	CK
Shift Work	5	32
Blue Light (400−495 nm)	3	21
Vaccination: All	1	10
Wearing A Brassiere	1	10
Wearing a Girdle	1	10
Electromagnetic Field Harms	3	4
Electromagnetic Radiation	3	4
5G Millimeter Wave Radiation	1	2
Electromagnetic Radiation: 1.8 GHz	1	2
Electromagnetic Radiation: 2.4 GHz	1	2
Electromagnetic Radiation: 6-24 GHz (5G)	1	2
Electromagnetic Radiation: 60 GHZ	1	2
Laptop Computer Use	1	1
Microwave Radiation	1	1
Mobile Phone Radiation	1	1
Wi-Fi Radiation	1	1

[+]

Amber lenses could be used to block blue light and improve sleep.Nov 30, 2009

Click here to read the entire abstract

Pubmed Data : Chronobiol Int. 2009 Dec ;26(8):1602-12. PMID: 20030543

Article Published Date : Nov 30, 2009

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation

Therapeutic Actions : Amber Lenses

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID: 28154742

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Delirium

[+]

Circadian misalignment reduces glucose tolerance, providing a mechanism to help explain the increased diabetes risk in shift workers.Apr 27, 2015

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 2015 Apr 28 ;112(17):E2225-34. Epub 2015 Apr 13. PMID: 25870289

Article Published Date : Apr 27, 2015

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Diabetes Mellitus: Type 2: Prevention

Additional Keywords : Increased Risk

Anti Therapeutic Actions : Shift Work

[+]

Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.Jun 14, 2015

Click here to read the entire abstract

Pubmed Data : J Neurol Sci. 2015 Jun 15 ;353(1-2):166-8. Epub 2015 Apr 7. PMID: 25930714

Article Published Date : Jun 14, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin, Inflammation, Multiple Sclerosis: Relapsing-Remitting

[+]

epigenetic regulation of CLOCK, BMAL1, CRY1 and PER1 may contribute to breast cancer in shift workers.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer. 2017 ;8(15):2876-2884. Epub 2017 Aug 24. PMID: 28928877

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Circadian Dysregulation

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Shift Work

[+]

Food intake during the biological night may contribute to other health problems associated with short sleep duration.Nov 03, 2015

Click here to read the entire abstract

Pubmed Data : Curr Biol. 2015 Nov 4. Epub 2015 Nov 4. PMID: 26549253

Article Published Date : Nov 03, 2015

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Diabetes Mellitus: Type 2, Insulin Resistance, Sleep Disorders

Additional Keywords : Risk Factors

[+]

From dawn to dusk-mimicking natural daylight exposure improves circadian rhythm entrainment in patients with severe brain injury.Jul 10, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sleep. 2022 Jul 11 ;45(7). PMID: 35290446

Article Published Date : Jul 10, 2022

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Traumatic Brain Injury

Therapeutic Actions : Light Therapy

Additional Keywords : Circadian Rhythm

[+]

Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. Mar 11, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mov Disord. 2016 Mar 12. Epub 2016 Mar 12. PMID: 26971528

Article Published Date : Mar 11, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Parkinson's Disease

Additional Keywords : Risk Factors

[+]

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Chronobiol Int. 2016 ;33(1):134-9. Epub 2016 Jan 5. PMID: 26730983

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin

Additional Keywords : Light Pollution

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Pineal calcification (DOC) might indicate a decrease of melatonin production, which consecutively might lead to a disturbed circadian rhythmicity in the sleep-wake cycle.Jun 30, 1998

Click here to read the entire abstract

Pubmed Data : Psychiatry Res. 1998 Jun 30;82(3):187-91. PMID: 9754443

Article Published Date : Jun 30, 1998

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin, Pineal Gland Calcification , Sleep Disorders

Additional Keywords : Diseases that are Linked

[+]

Probiotics ingestion prevents HDAC11-induced DEC205+ dendritic cell dysfunction in night shift nurses.Nov 28, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2019 Nov 29 ;9(1):18002. Epub 2019 Nov 29. PMID: 31784669

Article Published Date : Nov 28, 2019

Study Type : Human Study

Additional Links

Substances : Probiotics, Yoghurt

Diseases : Circadian Dysregulation

Pharmacological Actions : Immunomodulatory

Anti Therapeutic Actions : Shift Work

[+]

Sunlight exposure may act as a circadian pacemaker.Apr 01, 2010

Click here to read the entire abstract

Pubmed Data : J Biol Rhythms. 2010 Apr;25(2):113-22. PMID: 20348462

Article Published Date : Apr 01, 2010

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation

Therapeutic Actions : Sunlight exposure

[+]

This study suggests that reducing evening energy intake, eating more frequently, and fasting for longer nightly intervals may reduce systemic inflammation.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(8):e0136240. Epub 2015 Aug 25. PMID: 26305095

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein, Circadian Dysregulation, Inflammation, Insulin Resistance

Additional Keywords : Risk Factors

[+]

This study supports the association between depression and some alterations in circadian rhythms of behavior and sleep.May 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Psychiatr Danub. 2015 Jun ;27(2):190-2. PMID: 26057316

Article Published Date : May 31, 2015

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Depression

[+]

Typhoid vaccination produced significant impairments in several measures of sleep continuity.Aug 08, 2016

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2016 Aug 9. Epub 2016 Aug 9. PMID: 27503474

Article Published Date : Aug 08, 2016

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Sleep Disorders

Anti Therapeutic Actions : Vaccination: All

Adverse Pharmacological Actions : Inflammatory

[+]

Wearing either a bra or girdle affect skin, consequently adversely impacting circadian rhythms of core temperature and salivary melatoninNov 01, 2000

Click here to read the entire abstract

Pubmed Data : Chronobiol Int. 2000 Nov ;17(6):783-93. PMID: 11128295

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin

Anti Therapeutic Actions : Wearing A Brassiere, Wearing a Girdle

[+]

This finding was corroborated by clinical observation that PER2 down-regulation was associated with poor prognosis in breast cancer patients. Jul 22, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Proc Natl Acad Sci U S A. 2013 Jul 23 ;110(30):12331-6. Epub 2013 Jul 8. PMID: 23836662

Article Published Date : Jul 22, 2013

Study Type : Human In Vitro

Additional Links

Diseases : Breast Cancer, Cancer Metastasis, Circadian Dysregulation, Hypoxia

Additional Keywords : Gene Expression, PER2 Protein, Tumor Suppressor Proteins

[+]

Man-made radiofrequency (RF) electromagnetic fields have been shown to have effects on animal orientation responses.Sep 27, 2019

Click here to read the entire abstract

Pubmed Data : J R Soc Interface. 2019 Sep 27 ;16(158):20190285. Epub 2019 Sep 18. PMID: 31530135

Article Published Date : Sep 27, 2019

Study Type : Insect Study

Additional Links

Diseases : Circadian Dysregulation

Additional Keywords : electromagnetic radiation, EMF

Anti Therapeutic Actions : 5G Millimeter Wave Radiation, Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Electromagnetic Radiation: 2.4 GHz, Electromagnetic Radiation: 60 GHZ, Electromagnetic Radiation: 6-24 GHz (5G)

[+]

Apple polyphenol extract modulates bile acid metabolism and gut microbiota.Feb 16, 2022

Click here to read the entire abstract

Pubmed Data : Food Funct. 2022 Feb 17. Epub 2022 Feb 17. PMID: 35174840

Article Published Date : Feb 16, 2022

Study Type : Animal Study

Additional Links

Substances : Apple Polyphenols

Diseases : Circadian Dysregulation, High Fat Diet

Pharmacological Actions : Gastrointestinal Agents

[+]

Both melatonin and probiotic can significantly reduce intestinal injury and restore the expression of circadian rhythm-related genes and neuroplasticity molecules.Sep 14, 2023

Click here to read the entire abstract

Pubmed Data : J Hazard Mater. 2023 Sep 15 ;458:131949. Epub 2023 Jun 29. PMID: 37392641

Article Published Date : Sep 14, 2023

Study Type : Animal Study

Additional Links

Substances : Melatonin, Probiotics

Diseases : Circadian Dysregulation, Microplastic Toxicity, Neurodegenerative Diseases

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Gut-brain Axis

Problem Substances : Polystyrene nanoparticles

[+]

Both systemic and somatic disruption of circadian rhythms contribute to cancer progression.Jul 25, 2016

Click here to read the entire abstract

Pubmed Data : Cell Metab. 2016 Jul 26. Epub 2016 Jul 26. PMID: 27476975

Article Published Date : Jul 25, 2016

Study Type : Animal Study

Additional Links

Diseases : Cancers: All, Circadian Dysregulation, Lung Cancer

Additional Keywords : Risk Factors

[+]

Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon.Oct 16, 2017

Click here to read the entire abstract

Pubmed Data : Chronobiol Int. 2017 Oct 17:1-15. Epub 2017 Oct 17. PMID: 29039977

Article Published Date : Oct 16, 2017

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation, Gastrointestinal Inflammation

Additional Keywords : Risk Factors

[+]

Chronic jet lag accelerates tumor progression in mice. Nov 01, 2004

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2004 Nov 1;64(21):7879-85. PMID: 15520194

Article Published Date : Nov 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Cancers: All, Circadian Dysregulation, Jet Lag

[+]

Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : Cell Metab. 2015 Sep 1 ;22(3):448-59. Epub 2015 Jul 9. PMID: 26166747

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation, Leptin Resistance

Additional Keywords : Circadian Clock Proteins

[+]

Circadian disruption accelerates liver carcinogenesis in mice.Oct 13, 2009

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2009 Oct 13. Epub 2009 Oct 13. PMID: 19833225

Article Published Date : Oct 13, 2009

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation, Liver Cancer

[+]

Circadian disruption contributese to accelerating experimental cancer processes.Dec 01, 2009

Click here to read the entire abstract

Pubmed Data : Integr Cancer Ther. 2009 Dec;8(4):298-302. PMID: 20042408

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Cancers: All, Circadian Dysregulation

[+]

Dietary pterostilbene and resveratrol modulate the gut microbiota influenced by circadian rhythm dysregulation.Sep 09, 2021

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2021 Sep 10:e2100434. Epub 2021 Sep 10. PMID: 34506670

Article Published Date : Sep 09, 2021

Study Type : Animal Study

Additional Links

Substances : Pterostilbene, Resveratrol

Diseases : Circadian Dysregulation, Dysbiosis

Pharmacological Actions : Gastrointestinal Agents

[+]

Disrupting circadian rhythms promotes cancer-induced inflammation in mice.Apr 30, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav Immun Health. 2022 May ;21:100428. Epub 2022 Feb 8. PMID: 35199050

Article Published Date : Apr 30, 2022

Study Type : Animal Study

Additional Links

Diseases : Cancers: All, Circadian Dysregulation, Inflammation

Additional Keywords : Risk Factors

[+]

Doxorubicin persistently rewires cardiac circadian homeostasis in mice.Dec 31, 2019

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Pubmed Data : Arch Toxicol. 2020 Jan ;94(1):257-271. Epub 2019 Nov 25. PMID: 31768571

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Circadian Dysregulation

Additional Keywords : Increased Risk

[+]

Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer's disease model.Jul 08, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomolecules. 2021 Jul 9 ;11(7). Epub 2021 Jul 9. PMID: 34356628

Article Published Date : Jul 08, 2021

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Alzheimer's Disease, Circadian Dysregulation

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Gene Expression Regulation

[+]

Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID: 25677201

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Melatonin, Proanthocyanidins

Diseases : Circadian Dysregulation

Additional Keywords : Chronobiotic, Circadian Clock Proteins, Plant Extracts

[+]

Gut microbiota mediate the neuroprotective effect of Oolong tea polyphenols in cognitive impairment induced by circadian rhythm disorder.May 13, 2024

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2024 May 14. Epub 2024 May 14. PMID: 38745351

Article Published Date : May 13, 2024

Study Type : Animal Study

Additional Links

Substances : Tea: Oolong

Diseases : Circadian Dysregulation, Cognitive Decline/Dysfunction

Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroplasticity enhancement, Neuroprotective Agents

[+]

Lipoic acid helped to restore normal circadian rhythms in aging animals. Jun 01, 2014

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2014 Jun 2. Epub 2014 Jun 2. PMID: 24944020

Article Published Date : Jun 01, 2014

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Circadian Dysregulation, Dyslipidemias

Additional Keywords : Circadian Clock Proteins

[+]

Melatonin regulates circadian clock proteins expression in allergic airway inflammation.Mar 29, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Heliyon. 2024 Mar 30 ;10(6):e27471. Epub 2024 Mar 8. PMID: 38496876

Article Published Date : Mar 29, 2024

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Asthma, Circadian Dysregulation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Non-caloric artificial sweeteners can disturb the circadian sleep-wake cycle and cause behavioural inactivity in mice.Mar 25, 2016

Click here to read the entire abstract

Pubmed Data : Nutrition. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27189909

Article Published Date : Mar 25, 2016

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation

Problem Substances : Artificial Sweeteners, Saccharin

[+]

Oolong tea polyphenols ameliorate circadian rhythm of intestinal microbiome and liver clock genes in mouse model.Oct 03, 2019

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2019 Oct 4. Epub 2019 Oct 4. PMID: 31583884

Article Published Date : Oct 03, 2019

Study Type : Animal Study

Additional Links

Substances : Tea: Oolong

Diseases : Circadian Dysregulation

Additional Keywords : Gene Expression Regulation

[+]

Perinatal exposure to either Fluoxetine, or prenatal stress, leads to discernible and persistent changes in their circadian systems as adults.Dec 26, 2016

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2016 Dec 27. Epub 2016 Dec 27. PMID: 28028599

Article Published Date : Dec 26, 2016

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation, Stress

Additional Keywords : Risk Factors

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Proanthocyanidins restore the metabolic diurnal rhythm of subcutaneous white adipose tissue according to time-of-day consumption.May 26, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 May 27 ;14(11). Epub 2022 May 27. PMID: 35684049

Article Published Date : May 26, 2022

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Proanthocyanidins

Diseases : Circadian Dysregulation, Obesity

Additional Keywords : Anti-Obesity Agents

[+]

Stable forced desynchrony of circadian rhythms leads to the manifestation of a depressive-like phenotype.Oct 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : eNeuro. 2016 Nov-Dec;3(6). Epub 2017 Jan 6. PMID: 28090585

Article Published Date : Oct 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation, Depression

Additional Keywords : Risk Factors

[+]

The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm.Aug 22, 2022

Click here to read the entire abstract

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2022 Aug 23. Epub 2022 Aug 23. PMID: 35997288

Article Published Date : Aug 22, 2022

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Circadian Dysregulation, Nonalcoholic fatty liver disease (NAFLD), Obesity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Circadian Rhythm

[+]

These effects suggest that turmeric supplementation can be used as an inexpensive intervention to prevent circadian disruption-related immunosenescence.Aug 31, 2018

Click here to read the entire abstract

Pubmed Data : J Photochem Photobiol B. 2018 Sep ;186:69-80. Epub 2018 Jul 9. PMID: 30015062

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Melatonin, Turmeric

Diseases : Circadian Dysregulation, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Circadian Rhythm

[+]

These results reveal the tissue-specific nature of gene expression responses to chronic alcohol exposure and the ClockΔ19 mutation. Sep 01, 2015

Click here to read the entire abstract

Pubmed Data : Alcohol Clin Exp Res. 2015 Sep 2. Epub 2015 Sep 2. PMID: 26332085

Article Published Date : Sep 01, 2015

Study Type : Animal Study

Additional Links

Diseases : Alcohol Toxicity , Alcoholism, Circadian Dysregulation, Inflammation

Additional Keywords : Circadian Clock Proteins, Gene Expression

[+]

A disrupted circadian rhythm followed by oxidative stress and inflammatory processes could be the pathophysiological basis for several disorders of the central nervous system.Jul 05, 2015

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26144936

Article Published Date : Jul 05, 2015

Study Type : Review

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Inflammation, Neurodegenerative Diseases, Oxidative Stress, Psychiatric Disorders

Pharmacological Actions : Antioxidants

[+]

Because aberrant epigenetic modifications are an important hallmark of cancer cells, carcinogenic effects of circadian disruption may have an epigenetic basis.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin J Cancer. 2015 ;34:38. Epub 2015 Aug 8. PMID: 26253128

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Cancers: All, Circadian Dysregulation

Additional Keywords : Epigenetic Modification In Cancer, Gene Expression

[+]

Carbamate insecticides target human melatonin receptors resulting in alteration of the homeostatic balance of key regulatory processes.Jan 10, 2017

Click here to read the entire abstract

Pubmed Data : Chem Res Toxicol. 2017 Jan 11. Epub 2017 Jan 11. PMID: 28027439

Article Published Date : Jan 10, 2017

Study Type : In Vitro Study

Additional Links

Diseases : Circadian Dysregulation

Problem Substances : Pesticides

[+]

Circadian clock dysfunction plays a role in the pathogenesis of many common multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and cancer.May 03, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biotechnol Biotechnol Equip. 2014 May 4 ;28(3):379-386. Epub 2014 Jul 24. PMID: 26019524

Article Published Date : May 03, 2014

Study Type : Review

Additional Links

Diseases : Cancers: All, Cardiovascular Diseases, Circadian Dysregulation

[+]

Circadian disruption and sleep disruption could impair brain functions and contribute to the cumulative wear and tear on body systems.Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : Sleep Med Clin. 2015 Mar ;10(1):1-10. PMID: 26055668

Article Published Date : Feb 28, 2015

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation

[+]

Circadian disruption may contribute to the etiology of breast cancer.Oct 11, 2017

Click here to read the entire abstract

Pubmed Data : Neurosci Biobehav Rev. 2017 Oct 12. Epub 2017 Oct 12. PMID: 29032088

Article Published Date : Oct 11, 2017

Study Type : Review

Additional Links

Diseases : Breast Cancer, Circadian Dysregulation

Additional Keywords : Risk Factors

[+]

Despite divergences in the reported results, ELF-MF and radio frequency electromagnetic field have to be considered as factors possibly influencing the circadian system function.Jan 01, 2014

Click here to read the entire abstract

Pubmed Data : Biomed Res Int. 2014 ;2014:169459. Epub 2014 Jul 22. PMID: 25136557

Article Published Date : Jan 01, 2014

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation

Additional Keywords : Circadian Rhythm

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Endocrine Disruptor, Melatonin Interference

[+]

Disruption of the circadian rhythms in humans leads to increased incidence of myocardial infarction.Jul 05, 2015

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26144934

Article Published Date : Jul 05, 2015

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Myocardial Infarction, Myocardial Infarction: Prevention

Additional Keywords : Increased Risk, Risk Reduction

[+]

Effects of blue light on the circadian system and eye physiology.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Vis. 2016 ;22:61-72. Epub 2016 Jan 24. PMID: 26900325

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Eye Damage

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Enhancing circadian clock function might represent a novel strategy to control cancer progression.Feb 13, 2017

Click here to read the entire abstract

Pubmed Data : BMC Biol. 2017 Feb 14 ;15(1):13. Epub 2017 Feb 14. PMID: 28196531

Article Published Date : Feb 13, 2017

Study Type : In Vitro Study

Additional Links

Diseases : Cancers: All, Circadian Dysregulation, Colon Cancer, Melanoma

Additional Keywords : Circadian Clock Proteins

[+]

In the absence of definitive pharmacologic therapy, interventions prioritizing maintenance of normal circadian, sleep, and behavioral patterns have shown promise in delirium risk reduction.Jul 05, 2015

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26144937

Article Published Date : Jul 05, 2015

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Delirium

Additional Keywords : Risk Reduction

[+]

Parkinson's disease may be a neuroendocrine disorder of circadian function involving dopamine-melatonin imblance and pineal calcification.Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2009 Jun;12(3):135-40. PMID: 19145986

Article Published Date : Jun 01, 2009

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Parkinson's Disease, Pineal Gland Calcification

[+]

Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Obes Rev. 2017 Feb ;18 Suppl 1:15-24. PMID: 28164449

Article Published Date : Jan 31, 2017

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Metabolic Diseases, Obesity, Sleep Disorders

Additional Keywords : Risk Factors

Anti Therapeutic Actions : Shift Work

[+]

The cell cycle may be synchronized or slowed down through coupling with the circadian clock, which results in reduced tumor growth.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Neurol. 2015 ;6:96. Epub 2015 May 11. PMID: 26029155

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Cancers: All, Circadian Dysregulation

[+]

The role of microbiome in insomnia, circadian disturbance and depression.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Psychiatry. 2018 ;9:669. Epub 2018 Dec 5. PMID: 30568608

Article Published Date : Dec 31, 2017

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Depression, Insomnia

Additional Keywords : Microbiome

[+]

This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.Jul 21, 2015

Click here to read the entire abstract

Pubmed Data : Annu Rev Physiol. 2015 Jul 22. Epub 2015 Jul 22. PMID: 26208951

Article Published Date : Jul 21, 2015

Study Type : Review

Additional Links

Diseases : Circadian Dysregulation, Endocrine Diseases

Additional Keywords : Risk Factors

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This review discusses recent basic science findings on the interaction of the circadian rhythm and the innate immune system.Jul 04, 2015

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Pubmed Data : Curr Pharm Des. 2015 Jul 5. Epub 2015 Jul 5. PMID: 26144943

Article Published Date : Jul 04, 2015

Study Type : Review

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Diseases : Circadian Dysregulation

Additional Keywords : Immune Response

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View the Evidence: 63 Abstracts with Circadian Dysregulation Research

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Pineal calcification may contribute to melatonin deficiency and circadian timing irregularities.Dec 01, 1999

Amber lenses could be used to block blue light and improve sleep.Nov 30, 2009

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Circadian misalignment reduces glucose tolerance, providing a mechanism to help explain the increased diabetes risk in shift workers.Apr 27, 2015

Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.Jun 14, 2015

epigenetic regulation of CLOCK, BMAL1, CRY1 and PER1 may contribute to breast cancer in shift workers.Dec 31, 2016

Food intake during the biological night may contribute to other health problems associated with short sleep duration.Nov 03, 2015

From dawn to dusk-mimicking natural daylight exposure improves circadian rhythm entrainment in patients with severe brain injury.Jul 10, 2022

Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. Mar 11, 2016

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

Pineal calcification (DOC) might indicate a decrease of melatonin production, which consecutively might lead to a disturbed circadian rhythmicity in the sleep-wake cycle.Jun 30, 1998

Probiotics ingestion prevents HDAC11-induced DEC205+ dendritic cell dysfunction in night shift nurses.Nov 28, 2019

Sunlight exposure may act as a circadian pacemaker.Apr 01, 2010

This study suggests that reducing evening energy intake, eating more frequently, and fasting for longer nightly intervals may reduce systemic inflammation.Dec 31, 2014

This study supports the association between depression and some alterations in circadian rhythms of behavior and sleep.May 31, 2015

Typhoid vaccination produced significant impairments in several measures of sleep continuity.Aug 08, 2016

Wearing either a bra or girdle affect skin, consequently adversely impacting circadian rhythms of core temperature and salivary melatoninNov 01, 2000

This finding was corroborated by clinical observation that PER2 down-regulation was associated with poor prognosis in breast cancer patients. Jul 22, 2013

Man-made radiofrequency (RF) electromagnetic fields have been shown to have effects on animal orientation responses.Sep 27, 2019

Apple polyphenol extract modulates bile acid metabolism and gut microbiota.Feb 16, 2022

Both melatonin and probiotic can significantly reduce intestinal injury and restore the expression of circadian rhythm-related genes and neuroplasticity molecules.Sep 14, 2023

Both systemic and somatic disruption of circadian rhythms contribute to cancer progression.Jul 25, 2016

Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon.Oct 16, 2017

Chronic jet lag accelerates tumor progression in mice. Nov 01, 2004

Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Aug 31, 2015

Circadian disruption accelerates liver carcinogenesis in mice.Oct 13, 2009

Circadian disruption contributese to accelerating experimental cancer processes.Dec 01, 2009

Dietary pterostilbene and resveratrol modulate the gut microbiota influenced by circadian rhythm dysregulation.Sep 09, 2021

Disrupting circadian rhythms promotes cancer-induced inflammation in mice.Apr 30, 2022

Doxorubicin persistently rewires cardiac circadian homeostasis in mice.Dec 31, 2019

Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer's disease model.Jul 08, 2021

Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.Apr 30, 2015

Gut microbiota mediate the neuroprotective effect of Oolong tea polyphenols in cognitive impairment induced by circadian rhythm disorder.May 13, 2024

Lipoic acid helped to restore normal circadian rhythms in aging animals. Jun 01, 2014

Melatonin regulates circadian clock proteins expression in allergic airway inflammation.Mar 29, 2024

Non-caloric artificial sweeteners can disturb the circadian sleep-wake cycle and cause behavioural inactivity in mice.Mar 25, 2016

Oolong tea polyphenols ameliorate circadian rhythm of intestinal microbiome and liver clock genes in mouse model.Oct 03, 2019

Perinatal exposure to either Fluoxetine, or prenatal stress, leads to discernible and persistent changes in their circadian systems as adults.Dec 26, 2016

Proanthocyanidins restore the metabolic diurnal rhythm of subcutaneous white adipose tissue according to time-of-day consumption.May 26, 2022

Stable forced desynchrony of circadian rhythms leads to the manifestation of a depressive-like phenotype.Oct 31, 2016

The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm.Aug 22, 2022

These effects suggest that turmeric supplementation can be used as an inexpensive intervention to prevent circadian disruption-related immunosenescence.Aug 31, 2018

These results reveal the tissue-specific nature of gene expression responses to chronic alcohol exposure and the ClockΔ19 mutation. Sep 01, 2015

A disrupted circadian rhythm followed by oxidative stress and inflammatory processes could be the pathophysiological basis for several disorders of the central nervous system.Jul 05, 2015

Because aberrant epigenetic modifications are an important hallmark of cancer cells, carcinogenic effects of circadian disruption may have an epigenetic basis.Dec 31, 2014

Carbamate insecticides target human melatonin receptors resulting in alteration of the homeostatic balance of key regulatory processes.Jan 10, 2017

Circadian clock dysfunction plays a role in the pathogenesis of many common multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and cancer.May 03, 2014

Circadian disruption and sleep disruption could impair brain functions and contribute to the cumulative wear and tear on body systems.Feb 28, 2015

Circadian disruption may contribute to the etiology of breast cancer.Oct 11, 2017

Despite divergences in the reported results, ELF-MF and radio frequency electromagnetic field have to be considered as factors possibly influencing the circadian system function.Jan 01, 2014

Disruption of the circadian rhythms in humans leads to increased incidence of myocardial infarction.Jul 05, 2015

Effects of blue light on the circadian system and eye physiology.Dec 31, 2015

Enhancing circadian clock function might represent a novel strategy to control cancer progression.Feb 13, 2017

In the absence of definitive pharmacologic therapy, interventions prioritizing maintenance of normal circadian, sleep, and behavioral patterns have shown promise in delirium risk reduction.Jul 05, 2015

Parkinson's disease may be a neuroendocrine disorder of circadian function involving dopamine-melatonin imblance and pineal calcification.Jun 01, 2009

Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease.Jan 31, 2017

The cell cycle may be synchronized or slowed down through coupling with the circadian clock, which results in reduced tumor growth.Dec 31, 2014

The role of microbiome in insomnia, circadian disturbance and depression.Dec 31, 2017

This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.Jul 21, 2015

This review discusses recent basic science findings on the interaction of the circadian rhythm and the innate immune system.Jul 04, 2015

This review explores the circadian clock and breast cancer, and the growing role of epigenetics in breast cancer development and circadian rhythms.Jul 09, 2015

This review outlines the overlooked mechanisms of electromagnetic field damage and the critical role Earth's natural electromagnetic signaling plays in the biology of the human body.Jan 01, 2015

This study describes the profound adverse impact of disturbed circadian rhythms and sleep on the cardiovascular system, including recovery from myocardial infarction in acute care settings.Jul 04, 2015

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Circadian Dysregulation

View the Evidence:
63 Abstracts with Circadian Dysregulation Research