Circadian Dysregulation

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13 Substances Researched for Circadian Dysregulation
NameACCKFocus
Melatonin1050Locked
Probiotics212Locked
Yoghurt110Locked
Grape Seed Extract24Locked
Nobiletin 24Locked
Proanthocyanidins24Locked
Tea: Oolong24Locked
Alpha-Lipoic Acid12Locked
Apple Polyphenols12Locked
Pterostilbene12Locked
Resveratrol12Locked
Sulforaphane12Locked
Turmeric12Locked
6 Problem Substances Researched for Circadian Dysregulation
NameACCKFocus
Artificial Sweeteners12Locked
Fluoxetine (trade name Prozac) 12Locked
Polystyrene nanoparticles12Locked
Saccharin12Locked
Cell Phone Exposure11Locked
Pesticides11Locked
3 Therapeutic Actions Researched for Circadian Dysregulation
NameACCKFocus
Amber Lenses110Locked
Light Therapy110Locked
Sunlight exposure110Locked
16 Problematic Actions Researched for Circadian Dysregulation
NameACCKFocus
Shift Work532Locked
Blue Light (400−495 nm)321Locked
Vaccination: All110Locked
Wearing A Brassiere110Locked
Wearing a Girdle110Locked
Electromagnetic Field Harms34Locked
Electromagnetic Radiation34Locked
5G Millimeter Wave Radiation12Locked
Electromagnetic Radiation: 1.8 GHz12Locked
Electromagnetic Radiation: 2.4 GHz12Locked
Electromagnetic Radiation: 6-24 GHz (5G) 12Locked
Electromagnetic Radiation: 60 GHZ12Locked
Laptop Computer Use11Locked
Microwave Radiation11Locked
Mobile Phone Radiation11Locked
Wi-Fi Radiation11Locked

View the Evidence:
69 Abstracts with Circadian Dysregulation Research

[+]

Pineal calcification may contribute to melatonin deficiency and circadian timing irregularities.Dec 01, 1999

Pubmed Data : Neuropsychopharmacology. 1999 Dec;21(6):765-72. PMID: 10633482
Article Published Date : Dec 01, 1999
Study Type : Meta Analysis
Additional Links
Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin, Pineal Gland Calcification , Sleep Disorders
Additional Keywords : Diseases that are Linked
[+]

Amber lenses could be used to block blue light and improve sleep.Nov 30, 2009

Pubmed Data : Chronobiol Int. 2009 Dec ;26(8):1602-12. PMID: 20030543
Article Published Date : Nov 30, 2009
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation
Therapeutic Actions : Amber Lenses
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID: 28154742
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Circadian Dysregulation, Delirium
[+]

Circadian misalignment disrupts biomarkers of cardiovascular disease risk and promotes a hypercoagulable state.Sep 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Neurosci. 2024 Oct ;60(7):5450-5466. Epub 2024 Jul 25. PMID: 39053917
Article Published Date : Sep 30, 2024
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Circadian Dysregulation
Additional Keywords : Risk Factors
[+]

Circadian misalignment reduces glucose tolerance, providing a mechanism to help explain the increased diabetes risk in shift workers.Apr 27, 2015

Pubmed Data : Proc Natl Acad Sci U S A. 2015 Apr 28 ;112(17):E2225-34. Epub 2015 Apr 13. PMID: 25870289
Article Published Date : Apr 27, 2015
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Diabetes Mellitus: Type 2: Prevention
Additional Keywords : Increased Risk
Anti Therapeutic Actions : Shift Work
[+]

Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.Jun 14, 2015

Pubmed Data : J Neurol Sci. 2015 Jun 15 ;353(1-2):166-8. Epub 2015 Apr 7. PMID: 25930714
Article Published Date : Jun 14, 2015
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin, Inflammation, Multiple Sclerosis: Relapsing-Remitting
[+]

epigenetic regulation of CLOCK, BMAL1, CRY1 and PER1 may contribute to breast cancer in shift workers.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2017 ;8(15):2876-2884. Epub 2017 Aug 24. PMID: 28928877
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Circadian Dysregulation
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Shift Work
[+]

Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance.Apr 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Appl Physiol (1985). 2011 May ;110(5):1432-8. Epub 2011 Mar 17. PMID: 21415172
Article Published Date : Apr 30, 2011
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Computer display light exposure
Additional Keywords : Circadian Rhythm
[+]

Food intake during the biological night may contribute to other health problems associated with short sleep duration.Nov 03, 2015

Pubmed Data : Curr Biol. 2015 Nov 4. Epub 2015 Nov 4. PMID: 26549253
Article Published Date : Nov 03, 2015
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Diabetes Mellitus: Type 2, Insulin Resistance, Sleep Disorders
Additional Keywords : Risk Factors
[+]

From dawn to dusk-mimicking natural daylight exposure improves circadian rhythm entrainment in patients with severe brain injury.Jul 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sleep. 2022 Jul 11 ;45(7). PMID: 35290446
Article Published Date : Jul 10, 2022
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Traumatic Brain Injury
Therapeutic Actions : Light Therapy
Additional Keywords : Circadian Rhythm
[+]

Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. Mar 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mov Disord. 2016 Mar 12. Epub 2016 Mar 12. PMID: 26971528
Article Published Date : Mar 11, 2016
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Circadian Dysregulation, Parkinson's Disease
Additional Keywords : Risk Factors
[+]

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

Pubmed Data : Chronobiol Int. 2016 ;33(1):134-9. Epub 2016 Jan 5. PMID: 26730983
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin
Additional Keywords : Light Pollution
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Pineal calcification (DOC) might indicate a decrease of melatonin production, which consecutively might lead to a disturbed circadian rhythmicity in the sleep-wake cycle.Jun 30, 1998

Pubmed Data : Psychiatry Res. 1998 Jun 30;82(3):187-91. PMID: 9754443
Article Published Date : Jun 30, 1998
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin, Pineal Gland Calcification , Sleep Disorders
Additional Keywords : Diseases that are Linked
[+]

Probiotics ingestion prevents HDAC11-induced DEC205+ dendritic cell dysfunction in night shift nurses.Nov 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Nov 29 ;9(1):18002. Epub 2019 Nov 29. PMID: 31784669
Article Published Date : Nov 28, 2019
Study Type : Human Study
Additional Links
Substances : Probiotics, Yoghurt
Diseases : Circadian Dysregulation
Pharmacological Actions : Immunomodulatory
Anti Therapeutic Actions : Shift Work
[+]

Sunlight exposure may act as a circadian pacemaker.Apr 01, 2010

Pubmed Data : J Biol Rhythms. 2010 Apr;25(2):113-22. PMID: 20348462
Article Published Date : Apr 01, 2010
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation
Therapeutic Actions : Sunlight exposure
[+]

This study suggests that reducing evening energy intake, eating more frequently, and fasting for longer nightly intervals may reduce systemic inflammation.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(8):e0136240. Epub 2015 Aug 25. PMID: 26305095
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Circadian Dysregulation, Inflammation, Insulin Resistance
Additional Keywords : Risk Factors
[+]

This study supports the association between depression and some alterations in circadian rhythms of behavior and sleep.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychiatr Danub. 2015 Jun ;27(2):190-2. PMID: 26057316
Article Published Date : May 31, 2015
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Depression
[+]

Typhoid vaccination produced significant impairments in several measures of sleep continuity.Aug 08, 2016

Pubmed Data : Psychopharmacology (Berl). 2016 Aug 9. Epub 2016 Aug 9. PMID: 27503474
Article Published Date : Aug 08, 2016
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Sleep Disorders
Anti Therapeutic Actions : Vaccination: All
Adverse Pharmacological Actions : Inflammatory
[+]

Wearing either a bra or girdle affect skin, consequently adversely impacting circadian rhythms of core temperature and salivary melatoninNov 01, 2000

Pubmed Data : Chronobiol Int. 2000 Nov ;17(6):783-93. PMID: 11128295
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Circadian Dysregulation, Hormone Imbalances: Low Melatonin
Anti Therapeutic Actions : Wearing A Brassiere, Wearing a Girdle
[+]

This finding was corroborated by clinical observation that PER2 down-regulation was associated with poor prognosis in breast cancer patients. Jul 22, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Proc Natl Acad Sci U S A. 2013 Jul 23 ;110(30):12331-6. Epub 2013 Jul 8. PMID: 23836662
Article Published Date : Jul 22, 2013
Study Type : Human In Vitro
Additional Links
Diseases : Breast Cancer, Cancer Metastasis, Circadian Dysregulation, Hypoxia
Additional Keywords : Gene Expression, PER2 Protein, Tumor Suppressor Proteins
[+]

Man-made radiofrequency (RF) electromagnetic fields have been shown to have effects on animal orientation responses.Sep 27, 2019

Pubmed Data : J R Soc Interface. 2019 Sep 27 ;16(158):20190285. Epub 2019 Sep 18. PMID: 31530135
Article Published Date : Sep 27, 2019
Study Type : Insect Study
Additional Links
Diseases : Circadian Dysregulation
Additional Keywords : electromagnetic radiation, EMF
Anti Therapeutic Actions : 5G Millimeter Wave Radiation, Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Electromagnetic Radiation: 2.4 GHz, Electromagnetic Radiation: 60 GHZ, Electromagnetic Radiation: 6-24 GHz (5G)
[+]

Apple polyphenol extract modulates bile acid metabolism and gut microbiota.Feb 16, 2022

Pubmed Data : Food Funct. 2022 Feb 17. Epub 2022 Feb 17. PMID: 35174840
Article Published Date : Feb 16, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Circadian Dysregulation, High Fat Diet
Pharmacological Actions : Gastrointestinal Agents
[+]

Both melatonin and probiotic can significantly reduce intestinal injury and restore the expression of circadian rhythm-related genes and neuroplasticity molecules.Sep 14, 2023

Pubmed Data : J Hazard Mater. 2023 Sep 15 ;458:131949. Epub 2023 Jun 29. PMID: 37392641
Article Published Date : Sep 14, 2023
Study Type : Animal Study
Additional Links
Substances : Melatonin, Probiotics
Diseases : Circadian Dysregulation, Microplastic Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Gut-brain Axis
Problem Substances : Polystyrene nanoparticles
[+]

Both systemic and somatic disruption of circadian rhythms contribute to cancer progression.Jul 25, 2016

Pubmed Data : Cell Metab. 2016 Jul 26. Epub 2016 Jul 26. PMID: 27476975
Article Published Date : Jul 25, 2016
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Circadian Dysregulation, Lung Cancer
Additional Keywords : Risk Factors
[+]

Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon.Oct 16, 2017

Pubmed Data : Chronobiol Int. 2017 Oct 17:1-15. Epub 2017 Oct 17. PMID: 29039977
Article Published Date : Oct 16, 2017
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Gastrointestinal Inflammation
Additional Keywords : Risk Factors
[+]

Chronic jet lag accelerates tumor progression in mice. Nov 01, 2004

Pubmed Data : Cancer Res. 2004 Nov 1;64(21):7879-85. PMID: 15520194
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Circadian Dysregulation, Jet Lag
[+]

Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Aug 31, 2015

Pubmed Data : Cell Metab. 2015 Sep 1 ;22(3):448-59. Epub 2015 Jul 9. PMID: 26166747
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Leptin Resistance
Additional Keywords : Circadian Clock Proteins
[+]

Circadian disruption accelerates liver carcinogenesis in mice.Oct 13, 2009

Pubmed Data : Mutat Res. 2009 Oct 13. Epub 2009 Oct 13. PMID: 19833225
Article Published Date : Oct 13, 2009
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Liver Cancer
[+]

Circadian disruption contributese to accelerating experimental cancer processes.Dec 01, 2009

Pubmed Data : Integr Cancer Ther. 2009 Dec;8(4):298-302. PMID: 20042408
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Circadian Dysregulation
[+]

Cognitive impairment induced by circadian rhythm disorders involves hippocampal brain-derived neurotrophic factor reduction and amyloid-β deposition.Sep 22, 2024

Pubmed Data : Chronobiol Int. 2024 Sep 23:1-8. Epub 2024 Sep 23. PMID: 39311588
Article Published Date : Sep 22, 2024
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Circadian Dysregulation, Cognitive Decline/Dysfunction
[+]

Dietary pterostilbene and resveratrol modulate the gut microbiota influenced by circadian rhythm dysregulation.Sep 09, 2021

Pubmed Data : Mol Nutr Food Res. 2021 Sep 10:e2100434. Epub 2021 Sep 10. PMID: 34506670
Article Published Date : Sep 09, 2021
Study Type : Animal Study
Additional Links
Substances : Pterostilbene, Resveratrol
Diseases : Circadian Dysregulation, Dysbiosis
Pharmacological Actions : Gastrointestinal Agents
[+]

Disrupting circadian rhythms promotes cancer-induced inflammation in mice.Apr 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Behav Immun Health. 2022 May ;21:100428. Epub 2022 Feb 8. PMID: 35199050
Article Published Date : Apr 30, 2022
Study Type : Animal Study
Additional Links
Diseases : Cancers: All, Circadian Dysregulation, Inflammation
Additional Keywords : Risk Factors
[+]

Doxorubicin persistently rewires cardiac circadian homeostasis in mice.Dec 31, 2019

Pubmed Data : Arch Toxicol. 2020 Jan ;94(1):257-271. Epub 2019 Nov 25. PMID: 31768571
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Circadian Dysregulation
Additional Keywords : Increased Risk
[+]

Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer's disease model.Jul 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 Jul 9 ;11(7). Epub 2021 Jul 9. PMID: 34356628
Article Published Date : Jul 08, 2021
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Alzheimer's Disease, Circadian Dysregulation
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gene Expression Regulation
[+]

Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.Apr 30, 2015

Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID: 25677201
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Melatonin, Proanthocyanidins
Diseases : Circadian Dysregulation
Additional Keywords : Chronobiotic, Circadian Clock Proteins, Plant Extracts
[+]

Gut microbiota mediate the neuroprotective effect of Oolong tea polyphenols in cognitive impairment induced by circadian rhythm disorder.May 13, 2024

Pubmed Data : J Agric Food Chem. 2024 May 14. Epub 2024 May 14. PMID: 38745351
Article Published Date : May 13, 2024
Study Type : Animal Study
Additional Links
Substances : Tea: Oolong
Diseases : Circadian Dysregulation, Cognitive Decline/Dysfunction
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroplasticity enhancement, Neuroprotective Agents
[+]

Lipoic acid helped to restore normal circadian rhythms in aging animals. Jun 01, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Jun 2. Epub 2014 Jun 2. PMID: 24944020
Article Published Date : Jun 01, 2014
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Circadian Dysregulation, Dyslipidemias
Additional Keywords : Circadian Clock Proteins
[+]

Melatonin regulates circadian clock proteins expression in allergic airway inflammation.Mar 29, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2024 Mar 30 ;10(6):e27471. Epub 2024 Mar 8. PMID: 38496876
Article Published Date : Mar 29, 2024
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Asthma, Circadian Dysregulation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Non-caloric artificial sweeteners can disturb the circadian sleep-wake cycle and cause behavioural inactivity in mice.Mar 25, 2016

Pubmed Data : Nutrition. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27189909
Article Published Date : Mar 25, 2016
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation
Problem Substances : Artificial Sweeteners, Saccharin
[+]

Oolong tea polyphenols ameliorate circadian rhythm of intestinal microbiome and liver clock genes in mouse model.Oct 03, 2019

Pubmed Data : J Agric Food Chem. 2019 Oct 4. Epub 2019 Oct 4. PMID: 31583884
Article Published Date : Oct 03, 2019
Study Type : Animal Study
Additional Links
Substances : Tea: Oolong
Diseases : Circadian Dysregulation
Additional Keywords : Gene Expression Regulation
[+]

Perinatal exposure to either Fluoxetine, or prenatal stress, leads to discernible and persistent changes in their circadian systems as adults.Dec 26, 2016

Pubmed Data : Psychopharmacology (Berl). 2016 Dec 27. Epub 2016 Dec 27. PMID: 28028599
Article Published Date : Dec 26, 2016
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Stress
Additional Keywords : Risk Factors
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Proanthocyanidins restore the metabolic diurnal rhythm of subcutaneous white adipose tissue according to time-of-day consumption.May 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 May 27 ;14(11). Epub 2022 May 27. PMID: 35684049
Article Published Date : May 26, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Circadian Dysregulation, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Stable forced desynchrony of circadian rhythms leads to the manifestation of a depressive-like phenotype.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : eNeuro. 2016 Nov-Dec;3(6). Epub 2017 Jan 6. PMID: 28090585
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Depression
Additional Keywords : Risk Factors
[+]

Sulforaphane alleviates hepatic metabolic disorder and gut microbiota dysbiosis induced by circadian rhythm disruption under a high-fat dietOct 02, 2024

Pubmed Data : Mol Nutr Food Res. 2024 Oct 3:e2400535. Epub 2024 Oct 3. PMID: 39361249
Article Published Date : Oct 02, 2024
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Circadian Dysregulation, High Fat Diet
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective
[+]

Systemic Inflammation disrupts circadian rhythms and diurnal neuroimmune dynamics.Jul 06, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2024 Jul 7 ;25(13). Epub 2024 Jul 7. PMID: 39000563
Article Published Date : Jul 06, 2024
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation, Inflammation, Lipopolysaccharide-Induced Toxicity
[+]

The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm.Aug 22, 2022

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2022 Aug 23. Epub 2022 Aug 23. PMID: 35997288
Article Published Date : Aug 22, 2022
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Circadian Dysregulation, Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Circadian Rhythm
[+]

These effects suggest that turmeric supplementation can be used as an inexpensive intervention to prevent circadian disruption-related immunosenescence.Aug 31, 2018

Pubmed Data : J Photochem Photobiol B. 2018 Sep ;186:69-80. Epub 2018 Jul 9. PMID: 30015062
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Melatonin, Turmeric
Diseases : Circadian Dysregulation, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Circadian Rhythm
[+]

These results reveal the tissue-specific nature of gene expression responses to chronic alcohol exposure and the ClockΔ19 mutation. Sep 01, 2015

Pubmed Data : Alcohol Clin Exp Res. 2015 Sep 2. Epub 2015 Sep 2. PMID: 26332085
Article Published Date : Sep 01, 2015
Study Type : Animal Study
Additional Links
Diseases : Alcohol Toxicity , Alcoholism, Circadian Dysregulation, Inflammation
Additional Keywords : Circadian Clock Proteins, Gene Expression
[+]

A disrupted circadian rhythm followed by oxidative stress and inflammatory processes could be the pathophysiological basis for several disorders of the central nervous system.Jul 05, 2015

Pubmed Data : Curr Pharm Des. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26144936
Article Published Date : Jul 05, 2015
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Circadian Dysregulation, Inflammation, Neurodegenerative Diseases, Oxidative Stress, Psychiatric Disorders
Pharmacological Actions : Antioxidants
[+]

Because aberrant epigenetic modifications are an important hallmark of cancer cells, carcinogenic effects of circadian disruption may have an epigenetic basis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin J Cancer. 2015 ;34:38. Epub 2015 Aug 8. PMID: 26253128
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Diseases : Cancers: All, Circadian Dysregulation
Additional Keywords : Epigenetic Modification In Cancer, Gene Expression
[+]

Carbamate insecticides target human melatonin receptors resulting in alteration of the homeostatic balance of key regulatory processes.Jan 10, 2017

Pubmed Data : Chem Res Toxicol. 2017 Jan 11. Epub 2017 Jan 11. PMID: 28027439
Article Published Date : Jan 10, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Circadian Dysregulation
Problem Substances : Pesticides
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Circadian clock dysfunction plays a role in the pathogenesis of many common multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and cancer.May 03, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biotechnol Biotechnol Equip. 2014 May 4 ;28(3):379-386. Epub 2014 Jul 24. PMID: 26019524
Article Published Date : May 03, 2014
Study Type : Review
Additional Links
Diseases : Cancers: All, Cardiovascular Diseases, Circadian Dysregulation
[+]

Circadian disruption and sleep disruption could impair brain functions and contribute to the cumulative wear and tear on body systems.Feb 28, 2015

Pubmed Data : Sleep Med Clin. 2015 Mar ;10(1):1-10. PMID: 26055668
Article Published Date : Feb 28, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation
[+]

Circadian disruption may contribute to the etiology of breast cancer.Oct 11, 2017

Pubmed Data : Neurosci Biobehav Rev. 2017 Oct 12. Epub 2017 Oct 12. PMID: 29032088
Article Published Date : Oct 11, 2017
Study Type : Review
Additional Links
Diseases : Breast Cancer, Circadian Dysregulation
Additional Keywords : Risk Factors
[+]

Circadian disruptions and their role in the development of hypertension.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2024 ;18:1433512. Epub 2024 Aug 7. PMID: 39170672
Article Published Date : Dec 31, 2023
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Hypertension
[+]

Despite divergences in the reported results, ELF-MF and radio frequency electromagnetic field have to be considered as factors possibly influencing the circadian system function.Jan 01, 2014

Pubmed Data : Biomed Res Int. 2014 ;2014:169459. Epub 2014 Jul 22. PMID: 25136557
Article Published Date : Jan 01, 2014
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation
Additional Keywords : Circadian Rhythm
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Endocrine Disruptor, Melatonin Interference
[+]

Disruption of the circadian rhythms in humans leads to increased incidence of myocardial infarction.Jul 05, 2015

Pubmed Data : Curr Pharm Des. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26144934
Article Published Date : Jul 05, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Myocardial Infarction, Myocardial Infarction: Prevention
Additional Keywords : Increased Risk, Risk Reduction
[+]

Effects of blue light on the circadian system and eye physiology.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Vis. 2016 ;22:61-72. Epub 2016 Jan 24. PMID: 26900325
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Eye Damage
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Enhancing circadian clock function might represent a novel strategy to control cancer progression.Feb 13, 2017

Pubmed Data : BMC Biol. 2017 Feb 14 ;15(1):13. Epub 2017 Feb 14. PMID: 28196531
Article Published Date : Feb 13, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: All, Circadian Dysregulation, Colon Cancer, Melanoma
Additional Keywords : Circadian Clock Proteins
[+]

In the absence of definitive pharmacologic therapy, interventions prioritizing maintenance of normal circadian, sleep, and behavioral patterns have shown promise in delirium risk reduction.Jul 05, 2015

Pubmed Data : Curr Pharm Des. 2015 Jul 6. Epub 2015 Jul 6. PMID: 26144937
Article Published Date : Jul 05, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Delirium
Additional Keywords : Risk Reduction
[+]

Parkinson's disease may be a neuroendocrine disorder of circadian function involving dopamine-melatonin imblance and pineal calcification.Jun 01, 2009

Pubmed Data : Nutr Neurosci. 2009 Jun;12(3):135-40. PMID: 19145986
Article Published Date : Jun 01, 2009
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Parkinson's Disease, Pineal Gland Calcification
[+]

Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease.Jan 31, 2017

Pubmed Data : Obes Rev. 2017 Feb ;18 Suppl 1:15-24. PMID: 28164449
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Metabolic Diseases, Obesity, Sleep Disorders
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Shift Work
[+]

The cell cycle may be synchronized or slowed down through coupling with the circadian clock, which results in reduced tumor growth.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2015 ;6:96. Epub 2015 May 11. PMID: 26029155
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Diseases : Cancers: All, Circadian Dysregulation
[+]

The role of microbiome in insomnia, circadian disturbance and depression.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Psychiatry. 2018 ;9:669. Epub 2018 Dec 5. PMID: 30568608
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Depression, Insomnia
Additional Keywords : Microbiome
[+]

This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.Jul 21, 2015

Pubmed Data : Annu Rev Physiol. 2015 Jul 22. Epub 2015 Jul 22. PMID: 26208951
Article Published Date : Jul 21, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Endocrine Diseases
Additional Keywords : Risk Factors
[+]

This review discusses recent basic science findings on the interaction of the circadian rhythm and the innate immune system.Jul 04, 2015

Pubmed Data : Curr Pharm Des. 2015 Jul 5. Epub 2015 Jul 5. PMID: 26144943
Article Published Date : Jul 04, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation
Additional Keywords : Immune Response
[+]

This review explores the circadian clock and breast cancer, and the growing role of epigenetics in breast cancer development and circadian rhythms.Jul 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Jul 10 ;6(19):16866-82. PMID: 26220712
Article Published Date : Jul 09, 2015
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Breast Cancer, Circadian Dysregulation
Additional Keywords : Circadian Clock Proteins, Epigenetic Modification
[+]

This review outlines the overlooked mechanisms of electromagnetic field damage and the critical role Earth's natural electromagnetic signaling plays in the biology of the human body.Jan 01, 2015

Pubmed Data : Rev Environ Health. 2015 ;30(4):293-303. PMID: 26368042
Article Published Date : Jan 01, 2015
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Electrosensitivity, Multiple Chemical Sensitivity
Additional Keywords : Circadian Rhythm, electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF, Radio Frequency Electromagnetic Radiation Exposure
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Laptop Computer Use, Microwave Radiation, Mobile Phone Radiation, Wi-Fi Radiation
Problem Substances : Cell Phone Exposure
[+]

This study describes the profound adverse impact of disturbed circadian rhythms and sleep on the cardiovascular system, including recovery from myocardial infarction in acute care settings.Jul 04, 2015

Pubmed Data : Curr Pharm Des. 2015 Jul 5. Epub 2015 Jul 5. PMID: 26144940
Article Published Date : Jul 04, 2015
Study Type : Review
Additional Links
Diseases : Cardiovascular Diseases, Circadian Dysregulation, Myocardial Infarction
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Shift Work

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