Cirrhosis: Liver

Name	AC	CK
Coffee	2	40
Vitamin D	8	37
Zinc	3	30
Probiotics	4	24
Astragaloside	3	23
Amino Acids	2	20
Green Tea	1	20
Ornithine	2	20
Curcumin	6	19
Vitamin E	4	17
Fucoidan	3	14
Sea buckthorn	2	12
Taurine	2	12
Yoghurt	2	12
Flavonoids	6	11
Ayurvedic formulation: Liv52	1	10
Carnitine	1	10
Ginsenosides	7	10
L-Carnitine	1	10
Lactobacillus probiotics	1	10
Magnesium	1	10
Menatetrenone	1	10
Oxygen Therapies	1	10
Phyllanthus urinaria	1	10
Piperidines	1	10
Vitamin K2	1	10
Vitamin K2: Menaquinones (MK-4-14)	1	10
Paeoniflorin	5	9
Curcumol	6	8
Lycopene	4	7
Cordyceps sinensis	3	6
Resveratrol	3	6
Beta-Elemene	3	5
Ferulic acid	1	5
Herbs: General	1	5
Lotus	2	5
Ursolic Acid	2	5
Carbon 60	2	4
Fucoxanthin	2	4
Luteolin	2	4
Melatonin	2	4
Puerarin	2	4
Quercetin	2	4
Stevia	2	4
Bromelain	1	3
Honokiol	2	3
Hydroxytyrosol	1	3
Amygdalin	1	2
Andrographis	1	2
Artesunate	1	2
Artichoke	1	2
Asiatic Acid	1	2
Bamboo	1	2
Bee Venom	1	2
Bifidobacterium Longum	1	2
Biochanin A	1	2
Blueberry	1	2
Camel Milk	1	2
Chokeberry	1	2
Citrus naringin	1	2
Cryptoxanthin	1	2
DHA (Docosahexaenoic Acid)	1	2
Diosmin	1	2
Ellagic Acid	1	2
Garlic	1	2
Genistein	1	2
Hawthorn	1	2
Hesperidin	1	2
Honey	1	2
Honeysuckle	1	2
Hydrogen: Molecular	1	2
Isothiocyanates	1	2
Juniper	1	2
Lactobacillus plantarum	1	2
Lactobacillus salivarius	1	2
Ligustrazine	1	2
Litchi	1	2
Mangiferin	1	2
Medicinal Mushrooms	1	2
Mulberry	1	2
NAC (N-acetyl-L-cysteine)	1	2
Olive	1	2
Orthosiphon	1	2
Paeonol	1	2
Panax Notoginseng	1	2
Phosphatidylcholine	1	2
Policosanol	1	2
Raspberry	1	2
Rose	1	2
Rosemary	1	2
Saffron	1	2
Salvia miltiorrhiza	2	2
Silibinin	1	2
Silymarin	1	2
Vitamin C	1	2
Woodfordia fruticosa	1	2
Andrographolide	1	1
Astragalus	1	1
Berberine	1	1
Carotenoids	1	1
Chicory	1	1
D-Limonene	1	1
Dates	1	1
Inositol	1	1
Isoliquiritigenin	1	1
Milk Thistle	1	1
Myo-inositol	1	1
Phellinus Linteus	1	1
Phloretin	1	1
Pterostilbene	1	1
Rosemaric Acid	1	1
Tanshinone IIA	1	1
beta-Carotene	1	1

Name	AC	CK
Proton-Pump Inhibitors	2	20
Antipsychotic Drugs	1	10
Artificially Sweetened Beverages	1	10
Benzodiazepines	1	10
Gliadin	1	10
Gluten	1	10
Sugar Sweetened Beverages	1	10
Vinyl chloride	1	10
Wheat	1	10
Cholesterol Lowering Drugs	1	3
Cadmium	1	2

Name	AC	CK
Exercise	1	10
Head-Out Water Immersion	1	10
Oxygen Therapy	1	10
Traditional Chinese Medicine	1	5
Stem Cell Related Therapy	1	1
Sunlight exposure	1	1

Name	AC	CK	Focus
Western Diet	3	6

[+]

Coffee consumption can significantly reduce the risk for hepatic fibrosis and cirrhosis.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(6):e0132119. Epub 2015 Jun 29. PMID: 26121590

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Liver Cirrhosis, Liver Diseases, Vitamin D Deficiency

Additional Keywords : Mortality, Risk Factors, Risk Reduction

[+]

A probiotic yogurt demonstrates a significant rate of minimal hepatic encephalopathy reversal. Jul 01, 2008

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Pubmed Data : Am J Gastroenterol. 2008 Jul;103(7):1707-15. PMID: 18691193

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Pubmed Data : Biomed Rep. 2020 Dec ;13(6):65. Epub 2020 Oct 20. PMID: 33149909

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Pubmed Data : Clin Gastroenterol Hepatol. 2015 Aug ;13(8):1540-3. Epub 2014 Dec 9. PMID: 25496816

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Carnitine

Diseases : Cramp, Liver Cirrhosis

[+]

L-ornithine-L-aspartate infusions are therapetuic in patients with cirrhosis, eleveated ammonia levels and hepatic encephalopathyJun 01, 1997

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Pubmed Data : Hepatology. 1997 Jun;25(6):1351-60. PMID: 9185752

Article Published Date : Jun 01, 1997

Study Type : Human Study

Additional Links

Substances : Ornithine

Diseases : Ammonia: Elevated, Hepatic Encephalopathy, Liver Cirrhosis

[+]

Lactobacillus GG is safe and well-tolerated in cirrhosis and is associated with a reduction in endotoxemia and dysbiosis.Apr 30, 2014

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Pubmed Data : Aliment Pharmacol Ther. 2014 May ;39(10):1113-25. Epub 2014 Mar 16. PMID: 24628464

Article Published Date : Apr 30, 2014

Study Type : Human Study

Additional Links

Substances : Lactobacillus probiotics

Diseases : Dysbiosis, Inflammation, Liver Cirrhosis

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Microbiome

[+]

Long-term oxygen therapy might offer a new therapeutic approach to improve liver function in patients with cirrhosis with hypoxemia.Feb 01, 2007

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Pubmed Data : J Gastroenterol. 2007 Feb;42(2):176-80. Epub 2007 Mar 12. PMID: 17351808

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Oxygen Therapies

Diseases : Hepatopulmonary Syndrome, Hypoxia, Liver Cirrhosis

Therapeutic Actions : Oxygen Therapy

[+]

Magnesium deficiency is highly prevalent in cirrhotic patients.Feb 28, 2021

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Pubmed Data : Scand J Gastroenterol. 2021 Mar 1:1-6. Epub 2021 Mar 1. PMID: 33646920

Article Published Date : Feb 28, 2021

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Liver Cirrhosis, Magnesium Deficiency

[+]

Oral L-ornithine-L-aspartate is therapeutic in cirrhotic patients with hyperammonemic hepatic encephalopathyOct 01, 2006

Pubmed Data : JAMA. 2023 Aug 8 ;330(6):537-546. PMID: 37552302

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Pubmed Data : Phytomedicine. 2005 Sep;12(9):619-24. PMID: 16194047

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Ayurvedic formulation: Liv52

Diseases : Liver Cirrhosis

[+]

The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease.Mar 06, 2022

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Pubmed Data : BMC Gastroenterol. 2022 Mar 7 ;22(1):102. Epub 2022 Mar 7. PMID: 35255811

Article Published Date : Mar 06, 2022

Study Type : Human Study

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Substances : Yoghurt

Diseases : Liver Cirrhosis, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis.Jan 10, 2024

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Pubmed Data : Blood. 1999 May 1;93(9):2945-50. PMID: 10216089

Article Published Date : May 01, 1999

Study Type : Human Study

Additional Links

Substances : Vitamin E

Diseases : Liver Cirrhosis

[+]

Wilson's disease may manifest in liver cirrhosis and may be treated with zinc. Aug 01, 2006

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Pubmed Data : Clin Gastroenterol Hepatol. 2006 Aug;4(8):1069-71. Epub 2006 Jun 21. PMID: 16793346

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Pubmed Data : Biomed Res Int. 2015 ;2015:935903. Epub 2015 Dec 31. PMID: 26881209

Article Published Date : Jan 01, 2015

Study Type : Human In Vitro

Additional Links

Substances : Herbs: General

Diseases : Liver Cirrhosis

Therapeutic Actions : Traditional Chinese Medicine

Pharmacological Actions : Antioxidants, Regenerative

Additional Keywords : Liver Regeneration

[+]

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

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Pubmed Data : Chem Biol Interact. 2019 Feb 1 ;299:131-139. Epub 2018 Dec 11. PMID: 30543783

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Pubmed Data : Histochem Cell Biol. 2022 Sep ;158(3):279-296. Epub 2022 Jul 18. PMID: 35849204

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Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021 Nov ;37(6):611-615. PMID: 34821093

Article Published Date : Oct 31, 2021

Study Type : Animal Study

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Substances : Curcumol

Diseases : Liver Cirrhosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Ellagic acid exerted protective effects against carbon tetrachloride-induced cirrhosis through the inhibition of ROS formation and angiogenesis.Sep 30, 2017

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Pubmed Data : Phytother Res. 2024 Mar ;38(3):1367-1380. Epub 2024 Jan 12. PMID: 38217097

Article Published Date : Feb 29, 2024

Study Type : Animal Study

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Substances : Ginkgo biloba

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Interleukin-6 Downregulation, STAT3 Activation

[+]

Ginkgolic acid inhibits the expression of SAE1 and induces ferroptosis to exert an anti-hepatic fibrosis effect.Mar 31, 2024

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Pubmed Data : Int J Mol Sci. 2022 Sep 27 ;23(19). Epub 2022 Sep 27. PMID: 36232707

Article Published Date : Sep 26, 2022

Study Type : Animal Study

Additional Links

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor

[+]

Hepatoprotective effects of bochanin A on thioacetamide-induced liver cirrhosis.Nov 14, 2023

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Pubmed Data : J Gastroenterol Hepatol. 2013 Jul ;28(7):1223-33. PMID: 23425217

Article Published Date : Jun 30, 2013

Study Type : Animal Study, In Vitro Study

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Substances : Paeonol

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, NF-kappaB Inhibitor

Additional Keywords : Phytotherapy

[+]

Panax notoginseng saponins ameliorates experimental hepatic fibrosis.Mar 31, 2016

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Pubmed Data : Pak J Pharm Sci. 2023 Jul ;36(4):1177-1182. PMID: 37599493

Article Published Date : Jun 30, 2023

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Liver Cirrhosis

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

[+]

This study demonstrated the protective role of L. japonica ethanol extract in ameliorating nutritional steatohepatitis.Oct 20, 2015

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Astragaloside alleviates hepatic fibrosis by inhibiting PAR2 signalling expression.Dec 31, 2016

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Pubmed Data : Cell Physiol Biochem. 2017 ;41(3):1156-1166. Epub 2017 Feb 28. PMID: 28245465

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Liver Cirrhosis

Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis.Oct 04, 2023

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Pubmed Data : J Ethnopharmacol. 2023 Oct 5 ;314:116662. Epub 2023 May 18. PMID: 37207880

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Pubmed Data : Lab Invest. 2014 May ;94(5):503-16. Epub 2014 Mar 10. PMID: 24614199

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Review: the pathogenesis of ascites in cirrhosis. Apr 01, 1989

Pubmed Data : Biomed Pharmacother. 2020 Dec ;132:110815. Epub 2020 Oct 28. PMID: 33113421

Article Published Date : Nov 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Liver Cirrhosis

Pharmacological Actions : Hepatoprotective

[+]

The anti-toxic effect of the date palm fruit extract loaded on chitosan nanoparticles against CCl4-induced liver fibrosis in a mouse model.Apr 29, 2023

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Pubmed Data : Int J Biol Macromol. 2023 Apr 30 ;235:123804. Epub 2023 Feb 24. PMID: 36842736

Article Published Date : Apr 29, 2023

Study Type : In Vitro Study

Additional Links

Substances : Dates

Diseases : Inflammation, Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

The association of vitamin D with liver cirrhosis shows great potential for clinical application.Jun 30, 2016

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Pubmed Data : Ann Gastroenterol. 2016 Jul-Sep;29(3):297-306. Epub 2016 Apr 25. PMID: 27366029

Article Published Date : Jun 30, 2016

Study Type : Review

Additional Links

Substances : Vitamin D

Diseases : Liver Cirrhosis, Vitamin D Deficiency

Pharmacological Actions : Hepatoprotective

Additional Keywords : Risk Factors

[+]

The results indicated a novel treatment using natural products for liver diseases with anti-fibrotic effect.Dec 30, 2014

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View the Evidence: 205 Abstracts with Cirrhosis: Liver Research

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Coffee consumption can significantly reduce the risk for hepatic fibrosis and cirrhosis.Dec 31, 2014

Coffee consumption could lower the risks of liver cancers, liver diseases and liver cirrhosis.Dec 31, 2015

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis. Apr 01, 2021

Green tea intake reduces the risk of liver disease.Dec 31, 2014

25(OH)D3 deficiency is associated with advanced liver disease and low 25(OH)D3 levels are an indicator for a poor outcome and are associated with infectious complications.Dec 31, 2014

A probiotic yogurt demonstrates a significant rate of minimal hepatic encephalopathy reversal. Jul 01, 2008

A vitamin K2 preparation inhibits the development of liver cancer in patients with type C cirrhosis. Sep 01, 2010

Association between dietary magnesium intake and liver fibrosis among type 2 diabetes mellitus patients.Jun 30, 2024

Association between serum vitamin D level and immune imbalance in advanced schistosomiasis patients with liver fibrosis.Feb 03, 2021

Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection.May 13, 2012

Branched-chain amino acids improve the condition and outcome of patients with liver cirrhosis. Article 1Jul 01, 2005

Branched-chain amino acids improve the condition and outcome of patients with liver cirrhosis. Article 2Jun 01, 2003

Continued alcohol misuse in human cirrhosis is associated with an impaired gut-liver axis.Sep 18, 2017

Curcumin improved quality of life in liver cirrhotic patients.Feb 29, 2020

Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis.Nov 30, 2020

Head-Out Water Immersion has therapeutic effects in refractory ascites in patients with liver cirrhosis. Jul 01, 2009

Home exercise training improves exercise capacity in cirrhosis patients.Jan 07, 2018

L-carnitine appears to be safe and effective for reducing liver cramps in patients with cirrhosis. Jul 31, 2015

L-ornithine-L-aspartate infusions are therapetuic in patients with cirrhosis, eleveated ammonia levels and hepatic encephalopathyJun 01, 1997

Lactobacillus GG is safe and well-tolerated in cirrhosis and is associated with a reduction in endotoxemia and dysbiosis.Apr 30, 2014

Long-term oxygen therapy might offer a new therapeutic approach to improve liver function in patients with cirrhosis with hypoxemia.Feb 01, 2007

Magnesium deficiency is highly prevalent in cirrhotic patients.Feb 28, 2021

Oral L-ornithine-L-aspartate is therapeutic in cirrhotic patients with hyperammonemic hepatic encephalopathyOct 01, 2006

Patients with chronic liver disease have a high prevalence of anti-tTg antibodies, similar to patients with celiac disease.Jan 01, 2003

Phyllanthus Urinaria is useful in preventing or delaying the development of HBV-associated cirrhosis to hepatocellular carcinoma.Mar 24, 2013

Proton pump inhibitor therapy is associated with bacterial peritonitis in cirrhotic patients with ascites. May 01, 2009

Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis.Dec 18, 2014

Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis.Sep 06, 2019

Proton pump inhibitors are associated with the development of bacterial infections in patients with cirrhosis.Dec 31, 2017

Psychoactive medications are associated with an increased adjusted risk of falls and fall-related injuries in hospitalized patients with cirrhosis.Mar 25, 2015

Sea buckthorn improves the condition of patients with liver fibrosis/cirrhosis. Jul 01, 2003

Sugar-sweetened and artificially sweetened beverages and risk of liver cancer and chronic liver disease mortality.Aug 07, 2023

Supplementation with probiotics improves patients with liver cirrhosis.Nov 01, 2008

Taurine induces diuresis and natriuresis in cirrhotic patients with ascites. Jan 01, 1994

The Ayurvedic formula Liv-52 has hepatoprotective effects in patients with liver cirrhosis. Sep 01, 2005

The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease.Mar 06, 2022

The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis.Jan 10, 2024

This study demonstrated that red palm oil can modulate oxidative stress and inflammatory parameters.Apr 01, 2016

Toxoplasma seropositivity was high in patients with cirrhosis and associated higher grades of inflammation and necrosis signifying disease evolution.Sep 30, 2015

Vinyl chloride exposure is associated with increased risk of liver cancer and liver cirrhosis. Aug 01, 2004

Vitamin D-related immunomodulation in patients with liver cirrhosis.Nov 24, 2019

Vitamin E reduces lipid peroxidation and clotting activation in patients with liver cirrhosis. May 01, 1999

Wilson's disease may manifest in liver cirrhosis and may be treated with zinc. Aug 01, 2006

Zinc supplementation for 3 months seems effective and safe for treating hyperammonemia in liver cirrhosis.Oct 31, 2014

Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis.Jan 01, 2007

Fuzheng Huayu Recipe Ameliorates Liver Fibrosis by Restoring Balance between Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Hepatic Stellate Cells.Jan 01, 2015

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

Bromelain mitigates liver fibrosis via targeting hepatic stellate cells.May 31, 2023

Combination treatment with hydroxytyrosol and vitamin E improves NAFLD-related fibrosis.Sep 13, 2022

Fucoxanthin exert dose-dependent antifibrotic and anti-inflammatory effects on CCl4-induced liver fibrosis.Aug 31, 2023

Liver fibrosis has been attributed to lipid lowering medications.Sep 01, 2001

Neferine ameliorates nonalcoholic steatohepatitis through regulating AMPK pathway.May 31, 2023

Paeoniflorin coordinates macrophage polarization and mitigates liver inflammation and fibrogenesis.Dec 31, 2022

Piperine alleviates nonalcoholic steatohepatitis by inhibiting NF-κB-mediated hepatocyte pyroptosis.Dec 31, 2023

Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis.Nov 30, 2022

"Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress."Dec 31, 2010

Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.Mar 01, 2017

Active components from Sea Buckthorn regulate hepatic stellate cell activation and liver fibrogenesis.Nov 20, 2018

Albiflorin ameliorates thioacetamide-induced hepatic fibrosis.Apr 30, 2024

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation.Jun 05, 2018

Amygdalin ameliorates liver fibrosis through inhibiting activation of TGF-β/Smad signaling.Mar 31, 2023

Andrographis paniculata leaf extract prevents thioacetamide-induced liver cirrhosis in rats.Dec 31, 2013

ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene.Mar 31, 2009

Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.Jul 31, 2001

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Aronia melanocarpa polysaccharide ameliorates liver fibrosis.Nov 30, 2022

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway.Dec 31, 2018

Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment.Jun 30, 2017

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Astragaloside IV combats liver cirrhosis.Dec 31, 2018

Beta-cryptoxanthin prevents and reverses insulin resistance and steatohepatitis.Feb 28, 2015

Cirrhosis: Liver

View the Evidence:
205 Abstracts with Cirrhosis: Liver Research