Coenzyme Q10 Deficiency

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3 Substances Researched for Coenzyme Q10 Deficiency

Name	AC	CK
Coenzyme Q10	2	20
Astaxanthin	1	2
Vitamin E	1	2

5 Problem Substances Researched for Coenzyme Q10 Deficiency

Name	AC	CK
Statin Drugs	7	54
Atorvastatin	5	43
Pravastatin	2	20
Simvastatin	3	15
Lovastatin	2	12

Research Articles 13
Cumulative Knowledge Score 21
Overall Research Rating GOOD

View the Evidence:
13 Abstracts with Coenzyme Q10 Deficiency Research

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Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.Jun 01, 2004

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Pubmed Data : Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526

Article Published Date : Jun 01, 2004

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Coenzyme Q10 Deficiency, Statin-Induced Pathologies, Stroke

Problem Substances : Atorvastatin

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Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol.Jan 01, 2005

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Pubmed Data : J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, High Cholesterol, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

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Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

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Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254

Article Published Date : Nov 15, 2004

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Coenzyme Q10 Deficiency, Heart Failure, Hypertension, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents, Antioxidants

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic

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Coenzyme Q10 has a corrective effect on statin-induced lowering of plasma coenzyme Q10 levels.Dec 01, 2007

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Pubmed Data : Atherosclerosis. 2007 Dec;195(2):e182-9. Epub 2007 Aug 6. PMID: 17681347

Article Published Date : Dec 01, 2007

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies

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Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction. Sep 01, 1996

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Pubmed Data : Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID: 8877024

Article Published Date : Sep 01, 1996

Study Type : Human Study

Additional Links

Diseases : Blood Lactate/ Pyruvate Ratio: Elevated, Coenzyme Q10 Deficiency, Mitochondrial Dysfunction , Statin-Induced Pathologies

Pharmacological Actions : Enzyme Inhibitors

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

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Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. Jan 01, 2003

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Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs

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There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs. Jan 01, 1997

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Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515

Article Published Date : Jan 01, 1997

Study Type : Human Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies

Pharmacological Actions : Antioxidants

Problem Substances : Lovastatin, Pravastatin , Statin Drugs

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Simvastatin-induced lactic acidosis has been reported.Oct 01, 2002

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Pubmed Data : Clin Pharmacol Ther. 2002 Oct ;72(4):461-4. PMID: 12386648

Article Published Date : Oct 01, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Coenzyme Q10 Deficiency, Lactic Acidosis, Mitochondrial Dysfunction

Problem Substances : Simvastatin, Statin Drugs

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Statin precipitated lactic acidosis has been reported. Sep 01, 2004

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Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664

Article Published Date : Sep 01, 2004

Study Type : Human: Case Report

Additional Links

Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Lactic Acidosis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

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Astaxanthin and vitamin E may increase the endogenous production of coenzyme q10. Oct 01, 2010

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Pubmed Data : Br J Nutr. 2010 Oct;104(7):980-8. Epub 2010 Jun 14. PMID: 20540821

Article Published Date : Oct 01, 2010

Study Type : Animal Study

Additional Links

Substances : Astaxanthin, Vitamin E

Diseases : Coenzyme Q10 Deficiency

Pharmacological Actions : Antioxidants

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Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals.Jul 06, 1994

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Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828

Article Published Date : Jul 06, 1994

Study Type : Animal Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies

Problem Substances : Lovastatin

Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity

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Simvastatin worsens the myocardial mitochondrial respiration during ischemia probably due to depletion of coenzyme Q10. Sep 01, 1995

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Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576

Article Published Date : Sep 01, 1995

Study Type : Animal Study

Additional Links

Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Myocardial Ischemia, Statin-Induced Pathologies

Pharmacological Actions : Enzyme Inhibitors

Problem Substances : Simvastatin

Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity

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