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15 Substances Researched for Colic
NameACCKFocus
Lactobacillus reuteri651Locked
Bifidobacterium animalis220Locked
Fennel220Locked
Probiotics211Locked
Bifidobacterium110Locked
Bifidobacterium Breve110Locked
Fenugreek110Locked
Lactobacillus rhamnosus 110Locked
Lactobacillus rhamnosus GG110Locked
Lavender110Locked
Melissa (Lemonbalm)110Locked
Peppermint110Locked
Catnip12Locked
Ginger11Locked
Neem11Locked
2 Problem Substances Researched for Colic
NameACCKFocus
Cow Milk110Locked
Infant Formula: Cow's Milk Based110Locked
7 Therapeutic Actions Researched for Colic
NameACCKFocus
Chiropractic treatment330Locked
Massage/Therapeutic Touch330Locked
Breastfeeding220Locked
Dietary Modification: Allergen Free Diet220Locked
Aromatherapy 110Locked
Aromatherapy Massage110Locked
Photobiomodulation12Locked

View the Evidence:
30 Abstracts with Colic Research

[+]

A combination of Fenugreek, Fennel and Melissa extracts improves colic in breastfed infants within 1 week. Apr 01, 2005

Pubmed Data : Phytother Res. 2005 Apr;19(4):335-40. PMID: 16041731
Article Published Date : Apr 01, 2005
Study Type : Human Study
Additional Links
Substances : Fennel, Fenugreek, Melissa (Lemonbalm)
Diseases : Colic
[+]

Aromatherapy massage using lavender oil is effective as a treatment for infantile colic.Apr 01, 2012

Pubmed Data : Int J Nurs Pract. 2012 Apr ;18(2):164-9. PMID: 22435980
Article Published Date : Apr 01, 2012
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Colic
Therapeutic Actions : Aromatherapy , Aromatherapy Massage, Massage/Therapeutic Touch
[+]

Both infantile colic and prolonged crying were associated with high maternal depression scores. Aug 01, 2009

Pubmed Data : Acta Paediatr. 2009 Aug;98(8):1344-8. Epub 2009 Apr 28. PMID: 19432839
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Diseases : Colic, Infant Problems, Postpartum Depression
Therapeutic Actions : Breastfeeding
Additional Keywords : Risk Reduction
[+]

Bovine IgG may possibly be involved in the pathogenesis of infant colic.Mar 31, 1991

Pubmed Data : Pediatrics. 1991 Apr ;87(4):439-44. PMID: 2011419
Article Published Date : Mar 31, 1991
Study Type : Human Study
Additional Links
Diseases : Colic
Problem Substances : Cow Milk, Infant Formula: Cow's Milk Based
[+]

Chiropractic care for infants with colic may have an effect on long-term sequelae. Sep 30, 2009

Pubmed Data : J Manipulative Physiol Ther. 2009 Oct ;32(8):635-8. PMID: 19836599
Article Published Date : Sep 30, 2009
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Chiropractic treatment
Additional Keywords : Mother-Child Links
[+]

Chiropractic manual therapy improved crying behavior in infants with colic. Sep 30, 2012

Pubmed Data : J Manipulative Physiol Ther. 2012 Oct ;35(8):600-7. PMID: 23158465
Article Published Date : Sep 30, 2012
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Chiropractic treatment
[+]

Daily administration of L reuteri strain DSM 17938 appears to be safe in newborn infants with colic.Sep 28, 2017

Pubmed Data : J Pediatr. 2017 Sep 29. Epub 2017 Sep 29. PMID: 28969890
Article Published Date : Sep 28, 2017
Study Type : Human Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Colic
Pharmacological Actions : Gastrointestinal Agents
[+]

Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment.Feb 23, 2021

Pubmed Data : Benef Microbes. 2021 Feb 24 ;12(1):55-67. Epub 2020 Dec 22. PMID: 33350361
Article Published Date : Feb 23, 2021
Study Type : Human Study
Additional Links
Substances : Bifidobacterium Breve
Diseases : Colic
Pharmacological Actions : Gastrointestinal Agents
[+]

Fennel seed oil is superior to placebo in decreasing intensity of infantile colic. Jul 01, 2003

Pubmed Data : Altern Ther Health Med. 2003 Jul-Aug;9(4):58-61. PMID: 12868253
Article Published Date : Jul 01, 2003
Study Type : Human Study
Additional Links
Substances : Fennel
Diseases : Colic
[+]

Infants with colic treated with L reuteri for 30 days had a significantly decreased crying time.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pediatr. 2018 01 ;192:171-177.e1. Epub 2017 Sep 29. PMID: 28969887
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Colic
[+]

L. reuteri DSM 17938 was associated with a significant reduction in crying time in colicky infants, and showed improvement in maternal depression.Jan 06, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Pract. 2022 Jan 7 ;12(1):37-45. Epub 2022 Jan 7. PMID: 35076544
Article Published Date : Jan 06, 2022
Study Type : Human Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Colic, Depression
Pharmacological Actions : Gastrointestinal Agents
[+]

Massaging significantly improved colic symptoms during a one-week intervention for all outcomes. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med J Islam Repub Iran. 2016 ;30:351. Epub 2016 Apr 9. PMID: 27453882
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Massage/Therapeutic Touch
Additional Keywords : Significant Treatment Outcome
[+]

Peppermint is at least as effective as the drug simethicone in the treatment of infantile colic.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:981352. Epub 2012 Jul 12. PMID: 22844342
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Peppermint
Diseases : Colic
Additional Keywords : Natural Substances Versus Drugs
[+]

Postpartum maternal depressive symptoms and insecure attachment style are associated with infantile colic.May 01, 2006

Pubmed Data : Arch Dis Child. 2006 May;91(5):417-9. Epub 2006 Feb 1. PMID: 16452109
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Diseases : Colic, Infant Problems, Postpartum Depression
Therapeutic Actions : Breastfeeding
Additional Keywords : Diseases that are Linked
[+]

Probiotics decreased the mean duration per crying episode significantly more than a lactase dietary supplement in infants with colic.Feb 28, 2017

Pubmed Data : J Comp Eff Res. 2017 Mar ;6(2):137-144. Epub 2017 Jan 24. PMID: 28114795
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Substances : Bifidobacterium, Lactobacillus reuteri, Probiotics
Diseases : Colic
[+]

Removing cow's milk, eggs, peanuts, tree nuts, wheat, soy and fish from mother's diet reduces colic in breastfed infants. - Article 1Sep 01, 2004

Pubmed Data : Arch Pharm Res. 2004 Sep;27(9):930-6 . PMID: 16263986
Article Published Date : Sep 01, 2004
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Dietary Modification: Allergen Free Diet
[+]

Removing cow's milk, eggs, peanuts, tree nuts, wheat, soy and fish from mother's diet reduces colic in breastfed infants. - Article 3Oct 01, 1982

Pubmed Data : Arch Dis Child. 1982 Oct;57(10):742-7.PMID:8543745
Article Published Date : Oct 01, 1982
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Dietary Modification: Allergen Free Diet
[+]

Spinal manipulation is effective in relieving infantile colic.Sep 30, 1999

Pubmed Data : J Manipulative Physiol Ther. 1999 Oct ;22(8):517-22. PMID: 10543581
Article Published Date : Sep 30, 1999
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Chiropractic treatment
[+]

Supplementation of Bifidobacterium animalis is effective in reducing crying and fussing in infants diagnosed with infant colic.Nov 15, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Benef Microbes. 2021 Nov 16 ;12(6):531-540. Epub 2021 Sep 22. PMID: 34550055
Article Published Date : Nov 15, 2021
Study Type : Human Study
Additional Links
Substances : Bifidobacterium animalis
Diseases : Colic
Pharmacological Actions : Gastrointestinal Agents
[+]

Supplementation with Bifidobacterium animalis subsp. Lactis BB-12 is effective in managing infant colic.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aliment Pharmacol Ther. 2020 Jan ;51(1):110-120. Epub 2019 Dec 3. PMID: 31797399
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Substances : Bifidobacterium animalis
Diseases : Colic
Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory
[+]

These findings confirm that lactobacilli decrease cry and fuss time and provide a dietary support in exclusively breastfed infants with colic.Dec 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Dec 13 ;10(12). Epub 2018 Dec 13. PMID: 30551654
Article Published Date : Dec 12, 2018
Study Type : Human Study
Additional Links
Substances : Lactobacillus reuteri, Lactobacillus rhamnosus
Diseases : Colic
[+]

Treatment of infant colic with craniosacral therapy.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Complement Ther Med. 2022 Dec ;71:102885. Epub 2022 Sep 13. PMID: 36113708
Article Published Date : Nov 30, 2022
Study Type : Human Study
Additional Links
Diseases : Colic
Therapeutic Actions : Massage/Therapeutic Touch
[+]

White blood cells, TNF-α, and interleukin-6 in subjects with infantile colic treated with Lacticaseibacillus rhamnosus.May 29, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Benef Microbes. 2024 May 30:1-13. Epub 2024 May 30. PMID: 38821493
Article Published Date : May 29, 2024
Study Type : Human Study
Additional Links
Substances : Lactobacillus rhamnosus GG
Diseases : Colic
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Catnip has spasmolytic and bronchodilatory properties, confirming its traditional use in colic, diarrhea, cough and asthma. Jan 03, 2011

Pubmed Data : Neurosci Lett. 2011 Jan 3;487(1):70-2. Epub 2010 Oct 7. PMID: 19041706
Article Published Date : Jan 03, 2011
Study Type : Animal Study
Additional Links
Substances : Catnip
Diseases : Bronchial Asthma, Colic, Cough, Diarrhea
Pharmacological Actions : Antispasmodic, Bronchodilator Agents
Additional Keywords : Plant Extracts, Science Confirms Tradition
[+]

Influence of low intensive laser irradiation on ultrastructural changes in kidney tissue in experimental colic.Dec 31, 2005

Pubmed Data : Urologiia. 2006(3):47-50. PMID: 16889091
Article Published Date : Dec 31, 2005
Study Type : Animal Study
Additional Links
Diseases : Colic
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Renoprotective
[+]

Acorus calamus has antispasmodic activitity mediated through calcium channel blockade, confirming its traditional use for gastrointestinal disorders such as colic pain and diarrhea. Dec 01, 2006

Pubmed Data : Phytother Res. 2006 Dec;20(12):1080-4. PMID: 17009206
Article Published Date : Dec 01, 2006
Study Type : In Vitro Study
Additional Links
Diseases : Colic, Diarrhea
Pharmacological Actions : Antidiarrheals, Calcium Channel Blockers
Additional Keywords : Plant Extracts
[+]

Ginger is useful in gastrointestinal disorders due to its spasmolytic activity.Oct 01, 2005

Pubmed Data : Dig Dis Sci. 2005 Oct;50(10):1889-97. PMID: 16187193
Article Published Date : Oct 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Colic, Diarrhea, Dyspepsia
Pharmacological Actions : Antispasmodic
[+]

Review on pharmacological and toxicologyical effects of oleum azadirachti oil.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Biomed. 2013 Oct ;3(10):834-40. Epub 2013 Sep 4. PMID: 24075352
Article Published Date : Sep 30, 2013
Study Type : Review
Additional Links
Substances : Neem
Diseases : Asthma, Cardiovascular Diseases, Chickenpox, Colic, Conjunctivitis, Dysmenorrhea, Fever, Gastric Ulcer, Gout, Headache, Malaria, Muscle Soreness, Psoriasis, Rheumatism, Scabies
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antimicrobial, Antiviral Agents, Contraceptive Agents, Insect Repellents
Additional Keywords : Plant Oils
[+]

Supplementation with the probiotic L. reuteri in breastfed infants appears to be safe and effective for the management of infantile colic. Mar 01, 2016

Pubmed Data : J Pharm Pract. 2016 Mar 2. Epub 2016 Mar 2. PMID: 26940647
Article Published Date : Mar 01, 2016
Study Type : Review
Additional Links
Substances : Lactobacillus reuteri, Probiotics
Diseases : Colic
[+]

Lactobacillus reuteri is superior to simethicone in the treatment of infantile colic.Jan 01, 2007

Pubmed Data : Pediatrics. 2007 Jan;119(1):e124-30. PMID: 17200238
Article Published Date : Jan 01, 2007
Additional Links
Diseases : Colic

Copyright: mitarart / 123RF Stock Photo

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