Colorectal Cancer: Prevention

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41 Substances Researched for Colorectal Cancer: Prevention
NameACCKFocus
Magnesium360Locked
Fruit: All230Locked
Fiber322Locked
Vitamin D221Locked
Betaine 110Locked
Choline110Locked
Plantago ovata110Locked
Soy110Locked
Vegetables: All 110Locked
Curcumin47Locked
Flavonoids27Locked
Polyphenols26Locked
Chokeberry15Locked
Anthocyanins24Locked
Cocoa24Locked
Sweet Potato: Purple24Locked
Aloe Vera12Locked
Apple Polyphenols12Locked
Apples12Locked
Black Raspberry12Locked
Boswellia12Locked
Broccoli12Locked
Chlorophyll12Locked
Fish Oil12Locked
Mulberry12Locked
Oleuropein12Locked
Spinach12Locked
St. Johns Wort12Locked
Tomato12Locked
Walnut12Locked
Wogonin12Locked
Capsaicin11Locked
Endive (Cichorium endivia. L )11Locked
Folate11Locked
Lychee11Locked
Prebiotics11Locked
Probiotics11Locked
Vitamin B-1211Locked
Vitamin B-611Locked
Vitamin C11Locked
Vitamin E11Locked
1 Problem Substances Researched for Colorectal Cancer: Prevention
NameACCKFocus
Meat: Cooked12Locked
1 Therapeutic Actions Researched for Colorectal Cancer: Prevention
NameACCKFocus
Dietary Modification: Mediterranean Diet110Locked

View the Evidence:
47 Abstracts with Colorectal Cancer: Prevention Research

[+]

A higher magnesium intake seems to be associated with a modest reduction in the risk of CRC, in particular, colon cancer.Oct 31, 2012

Pubmed Data : Eur J Clin Nutr. 2012 Nov ;66(11):1182-6. Epub 2012 Oct 3. PMID: 23031849
Article Published Date : Oct 31, 2012
Study Type : Meta Analysis
Additional Links
Substances : Magnesium
Diseases : Colon Cancer: Prevention, Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Higher dietary magnesium intake seems to have a protective effect for cancer, especially colorectal cancer and in females.Dec 31, 2013

Pubmed Data : Nutr Cancer. 2014 ;66(6):915-23. Epub 2014 Jun 9. PMID: 24910891
Article Published Date : Dec 31, 2013
Study Type : Meta Analysis
Additional Links
Substances : Magnesium
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Additional Keywords : Risk Reduction
[+]

Magnesium intake reduces colorectal tumor riskAug 31, 2012

Pubmed Data : Am J Clin Nutr. 2012 Sep ;96(3):622-31. Epub 2012 Aug 1. PMID: 22854408
Article Published Date : Aug 31, 2012
Study Type : Meta Analysis
Additional Links
Substances : Magnesium
Diseases : Colon Cancer: Prevention, Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

There is a consistent inverse relationship between serum 25-hydroxyvitamin D levels and colorectal cancer was found.Mar 15, 2011

Pubmed Data : Int J Cancer. 2011 Mar 15 ;128(6):1414-24. PMID: 20473927
Article Published Date : Mar 15, 2011
Study Type : Meta Analysis
Additional Links
Substances : Vitamin D
Diseases : Colorectal Cancer: Prevention , Vitamin D Deficiency
Pharmacological Actions : Chemopreventive
[+]

This meta-analysis suggested that fruits consumption have a significant protective effect on colorectal adenoma risk.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2015 Oct ;94(42):e1599. PMID: 26496264
Article Published Date : Sep 30, 2015
Study Type : Meta Analysis
Additional Links
Substances : Fruit: All
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
Additional Keywords : Risk Reduction
[+]

A comparative ecological study of Spanish provinces showed consumption of P. ovata to be inversely correlated with mortality from colorectal cancer.Jan 01, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Epidemiol. 2009 ;19(4):206-11. Epub 2009 Jun 27. PMID: 19561384
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Plantago ovata
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Abstaining from excessive consumption of meat might be protective against developing colorectal cancer.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2017 May ;108(5):1065-1070. Epub 2017 May 16. PMID: 28256076
Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Problem Substances : Meat
[+]

Choline, betaine, and choline-containing compounds was inversely associated with colorectal cancer risk.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(3):e0118661. Epub 2015 Mar 18. PMID: 25785727
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Betaine , Choline
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
Additional Keywords : Risk Reduction
[+]

Consumption of soy foods may be associated with a reduction in colorectal cancer risk in women. Jan 01, 2010

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):148-58. PMID: 20056634
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Soy
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
Additional Keywords : Risk Reduction
[+]

Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

Pubmed Data : Br J Nutr. 2016 Oct ;116(7):1275-1287. Epub 2016 Sep 21. PMID: 27650133
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Flavonoids, Fruit: All, Vegetables: All
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Additional Keywords : COLORECTAL CANCER, Colorectal Cancer: Prevention, Flavonoids, Fruit: All, Risk Reduction, Vegetables: All
[+]

Frequent intake of peanut and its products may reduce colorectal cancer risk in women.Jan 13, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2006 Jan 14 ;12(2):222-7. PMID: 16482621
Article Published Date : Jan 13, 2006
Study Type : Human Study
Additional Links
Substances : Peanut
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Additional Keywords : Risk Reduction
[+]

Increasing the proportion of Australians who consume the recommended intake of fruit, vegetables and fibre could prevent up to 4% of all cancers.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aust N Z J Public Health. 2015 Oct ;39(5):422-8. PMID: 26437726
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Substances : Fiber, Fruit: All, Vegetables: All
Diseases : Cancers: All, Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
Additional Keywords : Risk Reduction
[+]

Individuals consuming the highest intakes of dietary fiber have reduced risks of incident colorectal adenoma and distal colon cancer.Aug 11, 2015

Pubmed Data : Am J Clin Nutr. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26269366
Article Published Date : Aug 11, 2015
Study Type : Human Study
Additional Links
Substances : Fiber
Diseases : Colon Cancer, Colon Cancer: Prevention, Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Risk Reduction
[+]

The results of this study suggests that gut microbiota could be related to colorectal cancer prevention and development.Nov 03, 2015

Pubmed Data : Oncol Rep. 2015 Nov 4. Epub 2015 Nov 4. PMID: 26549775
Article Published Date : Nov 03, 2015
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Additional Keywords : Microbiota, Risk Factors
[+]

This Italian study confirms a favourable role of Mediterranean diet on colorectal cancer risk.Aug 17, 2016

Pubmed Data : Br J Cancer. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27537381
Article Published Date : Aug 17, 2016
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer: Prevention
Therapeutic Actions : Dietary Modification: Mediterranean Diet
Additional Keywords : Risk Reduction
[+]

chokeberry juice inhibited Caco-2 cell proliferation by causing G(2)/M cell cycle arrest. Mar 31, 2007

Pubmed Data : J Nutr Biochem. 2007 Apr ;18(4):259-71. Epub 2006 Jul 24. PMID: 16860979
Article Published Date : Mar 31, 2007
Study Type : Human In Vitro
Additional Links
Substances : Chokeberry, Flavonoids, Polyphenols
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive
[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID: 30338040
Article Published Date : Sep 21, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
Additional Keywords : Anti-cancer
[+]

A mixture of phytochemicals naturally present in foods represents a plausible chemopreventive agent for colorectal cancer.May 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2011 Jun ;4(6):907-15. Epub 2011 Mar 7. PMID: 21383028
Article Published Date : May 31, 2011
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Apples, Flavonoids
Diseases : Colon Polyps, Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antioxidants, Chemopreventive
Additional Keywords : Dietary Concentrations
[+]

Anthocyanin enriched sweet potatoes may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms.Oct 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2013 Nov ;57(11):1908-17. Epub 2013 Jun 19. PMID: 23784800
Article Published Date : Oct 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Fiber, Sweet Potato: Purple
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Plant Extracts, Risk Reduction
[+]

Anthocyanin extracts from purple sweet potato exerted strong antioxidant effects in vitro and also had anti-aging, anti-hyperglycemic, and anti-tumor activities.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2013 Oct ;7(5):359-65. Epub 2013 Oct 1. PMID: 24133614
Article Published Date : Sep 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Sweet Potato: Purple
Diseases : Colorectal Cancer: Prevention , Gastric Cancer, Hyperglycemia, Sarcomas
Pharmacological Actions : Antioxidants, Apoptotic, Chemopreventive, Hypoglycemic Agents
Additional Keywords : Plant Extracts
[+]

Berberine significantly alleviated the development of colorectal cancer in mice fed with high fat diet.Sep 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 8 ;23(9). Epub 2018 Sep 8. PMID: 30205580
Article Published Date : Sep 07, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Cocoa may be a potential agent in the prevention and treatment of colitis-associated cancer.Aug 09, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 10. Epub 2015 Aug 10. PMID: 26355019
Article Published Date : Aug 09, 2015
Study Type : Animal Study
Additional Links
Substances : Cocoa
Diseases : Colitis, Colorectal Cancer: Prevention , Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Chemopreventive, Interleukin-6 Downregulation, STAT3 Inhibitor
[+]

Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biofactors. 2015 Jan-Feb;41(1):1-14. Epub 2014 Dec 24. PMID: 25545372
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cocoa
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Nrf2 activation
[+]

Curcumin and boswellic acid induced upregulation of tumor suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells.Apr 30, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 May ;8(5):431-43. Epub 2015 Feb 23. PMID: 25712055
Article Published Date : Apr 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Boswellia, Curcumin
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, MicroRNA modulator
Additional Keywords : Natural Substance Synergy
[+]

Curcumin could inhibit DMH-induced rat colorectal carcinogenesis and the growth of in vitro cultured HT 29 cell line.Mar 31, 2015

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Apr ;35(4):471-5. PMID: 26043573
Article Published Date : Mar 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.Jul 31, 2015

Pubmed Data : Nutr Res. 2015 Aug ;35(8):726-35. Epub 2015 Jun 1. PMID: 26094212
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer: Prevention , Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Dietary walnut supplementation led to suppression of colorectal cancer in mice.Jun 30, 2015

Pubmed Data : J Nutr Biochem. 2015 Jul ;26(7):776-83. Epub 2015 Apr 1. PMID: 25882694
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, MicroRNA modulator
[+]

Fish oil improves the lipid profile and reduces precancerous colon lesions.May 01, 2012

Pubmed Data : Nutr Cancer. 2012 May ;64(4):569-79. Epub 2012 Apr 6. PMID: 22483364
Article Published Date : May 01, 2012
Study Type : Animal Study
Additional Links
Substances : Fish Oil
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Freeze-dried black raspberries produced beneficial effects against colonic adenoma development in mice and modulated multiple metabolic pathways.Aug 04, 2015

Pubmed Data : Carcinogenesis. 2015 Aug 5. Epub 2015 Aug 5. PMID: 26246425
Article Published Date : Aug 04, 2015
Study Type : Animal Study
Additional Links
Substances : Black Raspberry
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Enzyme Inhibitors
Additional Keywords : Metabolites
[+]

Lactobacillus acidophilus-fermented germinated brown rice suppresses preneoplastic lesions of the colon.Nov 08, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 9 ;11(11). Epub 2019 Nov 9. PMID: 31717536
Article Published Date : Nov 08, 2019
Study Type : Animal Study
Additional Links
Substances : Brown Rice: Pre-Germinated, Fermented Foods and Beverages, Lactobacillus Acidophilus
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:17348. Epub 2015 Nov 30. PMID: 26615818
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Colitis, Colorectal Cancer: Prevention , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Naringin prevented colitis and colorectal carcinogenesisMar 25, 2018

Pubmed Data : Cancer Biol Ther. 2018 Mar 26:1-10. Epub 2018 Mar 26. PMID: 29580144
Article Published Date : Mar 25, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents
[+]

Oleuropein supplementation could be a promising protective agent against colitis-associated colorectal cancer.Sep 28, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26502315
Article Published Date : Sep 28, 2015
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin pathway down-regulation
[+]

St. John's wort extract had chemopreventive properties against colorectal cancer through attenuation of pro-inflammatory processes.Aug 31, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Sep ;8(9):786-95. Epub 2015 Jun 11. PMID: 26069204
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Dose Response, Plant Extracts
[+]

The protective effects of fermented kefir milk on azoxymethane-induced aberrant crypt formation in mice colon.May 31, 2018

Pubmed Data : Tissue Cell. 2018 Jun ;52:51-56. Epub 2018 Mar 27. PMID: 29857828
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Kefir
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents
[+]

These results show that Chl concentrations encountered in Chl-rich green vegetables can provide substantial cancer chemoprotection, and suggest that they do so by reducing carcinogen bioavailability.Jan 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Chem Toxicol. 2012 Feb ;50(2):341-52. Epub 2011 Nov 3. PMID: 22079312
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : Chlorophyll, Spinach
Diseases : Cancers: All, Colon Cancer: Prevention, Colorectal Cancer: Prevention , Liver Cancer, Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Dietary Concentrations, Plant Extracts
[+]

These results suggest that both aloe vera gel and powder may have chemopreventive effects on colorectal carcinogenesis under the high fat diets.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(2):683-7. PMID: 25684508
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

This study supports the hypothesis that a diet rich in tomato and broccoli can reduce or prevent dietary carcinogen induced cancers.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(11):e79842. Epub 2013 Nov 27. PMID: 24312188
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Broccoli, Tomato
Diseases : Breast Cancer, Cancers: All, Colorectal Cancer: Prevention , Prostate Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Dietary Concentrations, Dietary Modification
Problem Substances : Meat: Cooked
[+]

Wogonin effectively suppressed inflammation associated colon carcinogenesis and cancer development in mice.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2014 ;5:e1283. Epub 2014 Jun 5. PMID: 24901054
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anti Inflammatory, Antineoplastic Agents, Antiproliferative , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

(3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid from Cichorium endivia. L induces apoptosis of human colorectal cancer HCT-8 cells.Dec 31, 2011

Pubmed Data : Molecules. 2012 ;18(1):418-29. Epub 2012 Dec 28. PMID: 23275050
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Endive (Cichorium endivia. L )
Diseases : Colon Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Apoptotic
[+]

A polyphenol rich litchi seed extract could serve as a potential chemopreventive agent for colorectal cancer.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Biotechnol. 2012 ;2012:341479. Epub 2012 Oct 3. PMID: 23093841
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lychee, Polyphenols
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive
Additional Keywords : Plant Extracts
[+]

A remarkable preventive role of many vitamins like B6, B9, B12 and D on the risk of developing CRC was suggested by a large number of observational studies.May 06, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 May 7 ;21(17):5191-5209. PMID: 25954093
Article Published Date : May 06, 2015
Study Type : Review
Additional Links
Substances : Folate, Vitamin B-12, Vitamin B-6, Vitamin C, Vitamin D, Vitamin E
Diseases : Celiac Disease, Colorectal Cancer, Colorectal Cancer: Prevention , Gastrointestinal Diseases
Pharmacological Actions : Gastrointestinal Agents
[+]

A synergistic induction of apoptosis and inhibition of cell proliferation was observed in human colorectal cancer cells treated with the combination of capsaicin and DIM.May 05, 2015

Pubmed Data : J Agric Food Chem. 2015 May 6 ;63(17):4297-304. Epub 2015 Apr 22. PMID: 25876645
Article Published Date : May 05, 2015
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dietary Concentrations, Natural Substance Synergy
[+]

Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.Dec 31, 2014

Pubmed Data : Anticancer Drugs. 2015 Jan ;26(1):15-24. PMID: 25229889
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Apoptotic, Chemopreventive
[+]

In this review, role of probiotics and prebiotics in the prevention of colorectal cancer has been discussed.Jan 31, 2016

Pubmed Data : Best Pract Res Clin Gastroenterol. 2016 Feb ;30(1):119-31. Epub 2016 Feb 19. PMID: 27048903
Article Published Date : Jan 31, 2016
Study Type : Review
Additional Links
Substances : Prebiotics, Probiotics
Diseases : Colorectal Cancer: Prevention
Pharmacological Actions : Chemopreventive
Additional Keywords : Microbiota
[+]

Long-term administration of ω-3 PUFAs as a dietary supplement can be used as a strategy either to prevent CAC in patients.Aug 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27566583
Article Published Date : Aug 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Survivin Down-Regulation
[+]

Protective effects of kefir against zearalenone toxicity mediated by oxidative stress in cultured HCT-116 cells.Dec 31, 2018

Pubmed Data : Toxicon. 2019 Jan ;157:25-34. Epub 2018 Nov 16. PMID: 30448289
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Kefir
Diseases : Colorectal Cancer: Prevention , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

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