Creatine Phosphokinase (CK): Elevated

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1 Substances Researched for Creatine Phosphokinase (CK): Elevated

Name	AC	CK	Focus
Astaxanthin	1	10

5 Problem Substances Researched for Creatine Phosphokinase (CK): Elevated

Name	AC	CK
Statin Drugs	7	55
Lovastatin	2	13
Pitavastatin	1	10
Simvastatin	1	10
Fluvastatin	1	2

Research Articles 10
Cumulative Knowledge Score 16
Overall Research Rating GOOD

View the Evidence:
10 Abstracts with Creatine Phosphokinase (CK): Elevated Research

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[+]

Astaxanthin supplementation may have a beneficial effect on muscle damage and oxidative stress markers in atheletes. Jul 31, 2012

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Pubmed Data : J Sports Med Phys Fitness. 2012 Aug ;52(4):382-92. PMID: 22828460

Article Published Date : Jul 31, 2012

Study Type : Human Study

Additional Links

Substances : Astaxanthin

Diseases : AST: Elevated, Athletic Performance, Creatine Phosphokinase (CK): Elevated, Muscle Damage: Exercise-Induced

Pharmacological Actions : Antioxidants

[+]

Exercise exacerbates cerivastatin-induced skeletal muscle toxicity.Dec 01, 2005

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Pubmed Data : Toxicol Sci. 2005 Dec ;88(2):551-61. Epub 2005 Sep 1. PMID: 16141437

Article Published Date : Dec 01, 2005

Study Type : Human Study

Additional Links

Diseases : Athletic Performance, Creatine Phosphokinase (CK): Elevated, GGT, Muscle Damage: Exercise-Induced, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

Lovastatin increases exercise-induced skeletal muscle injury in human subjects. Oct 01, 1997

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Pubmed Data : Metabolism. 1997 Oct ;46(10):1206-10. PMID: 9322808

Article Published Date : Oct 01, 1997

Study Type : Human Study

Additional Links

Diseases : Athletic Performance, Creatine Phosphokinase (CK): Elevated, Muscle Damage: Exercise-Induced, Muscle Soreness: Exercise-Induced, Muscle Stiffness: Exercise-Induced, Statin-Induced Pathologies

Problem Substances : Lovastatin

Adverse Pharmacological Actions : Myotoxicity

[+]

Musclar side effects associated with statin drug use are related to oxidative stress. Aug 01, 2001

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Pubmed Data : J Clin Pharm Ther. 2001 Aug ;26(4):303-10. PMID: 11493374

Article Published Date : Aug 01, 2001

Study Type : Human Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Isoprostane 8-epi-PGF2alpha: Elevated, Myalgias, Oxidative Stress, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Myotoxicity, Oxidant

[+]

Pitavastatin results in an increased eGFR after 104 weeks of treatment, indicating a possible effect of the statin on CKD.Jun 30, 2010

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Pubmed Data : J Atheroscler Thromb. 2010 Jun 30 ;17(6):601-9. Epub 2010 May 7. PMID: 20460830

Article Published Date : Jun 30, 2010

Study Type : Human Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Estimated glomerular filtration rate (eGFR): Elevated , Statin-Induced Pathologies

Problem Substances : Pitavastatin

[+]

Statin drugs may cause high elevations of creatine phosphokinase (CK) in patients with unnoticed hypothyroidism.Jun 01, 2006

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Pubmed Data : Endocr J. 2006 Jun ;53(3):401-5. Epub 2006 May 25. PMID: 16723812

Article Published Date : Jun 01, 2006

Study Type : Human Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Hypothyroidism, Statin-Induced Pathologies

Additional Keywords : Drug Interaction

Problem Substances : Statin Drugs

[+]

Statin drugs, particularly simivastatin, increase the risk for significant creatine kinase elevation.Jan 01, 2010

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Pubmed Data : Am J Cardiovasc Drugs. 2010 ;10(3):187-92. PMID: 20524720

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Myopathies, Statin-Induced Pathologies

Problem Substances : Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

The FDA adverse event reporting system reveals statin-associated muscular and renal adverse events.Jan 01, 2011

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Pubmed Data : PLoS One. 2011 ;6(12):e28124. Epub 2011 Dec 20. PMID: 22205938

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Death: Statin-Induced, Kidney Failure: Acute, Myalgias, Rhabdomyolysis

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Nephrotoxic

[+]

Increased lipid peroxidation in a patient with CK-elevation and muscle pain during statin therapy has been reported. Nov 01, 2000

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Pubmed Data : Atherosclerosis. 2000 Nov ;153(1):255-6. PMID: 11058722

Article Published Date : Nov 01, 2000

Study Type : Human: Case Report

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Lipid Peroxidation, Statin-Induced Pathologies

Problem Substances : Lovastatin, Statin Drugs

Adverse Pharmacological Actions : Oxidant

[+]

Statin administration in animals results in a myopathy characterized by decreased muscle force and elevated plasma CK level.Nov 09, 2011

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Pubmed Data : J Muscle Res Cell Motil. 2011 Nov 9. Epub 2011 Nov 9. PMID: 22068225

Article Published Date : Nov 09, 2011

Study Type : Animal Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated, Myalgias, Myopathies, Statin-Induced Pathologies

Problem Substances : Fluvastatin, Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

Research Articles 10
Cumulative Knowledge Score 16
Overall Research Rating GOOD

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Focus Your Research

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View the Evidence: 10 Abstracts with Creatine Phosphokinase (CK): Elevated Research

Limited to Members Only

Currently Available Sorting Options

Astaxanthin supplementation may have a beneficial effect on muscle damage and oxidative stress markers in atheletes. Jul 31, 2012

Exercise exacerbates cerivastatin-induced skeletal muscle toxicity.Dec 01, 2005

Lovastatin increases exercise-induced skeletal muscle injury in human subjects. Oct 01, 1997

Musclar side effects associated with statin drug use are related to oxidative stress. Aug 01, 2001

Pitavastatin results in an increased eGFR after 104 weeks of treatment, indicating a possible effect of the statin on CKD.Jun 30, 2010

Statin drugs may cause high elevations of creatine phosphokinase (CK) in patients with unnoticed hypothyroidism.Jun 01, 2006

Statin drugs, particularly simivastatin, increase the risk for significant creatine kinase elevation.Jan 01, 2010

The FDA adverse event reporting system reveals statin-associated muscular and renal adverse events.Jan 01, 2011

Increased lipid peroxidation in a patient with CK-elevation and muscle pain during statin therapy has been reported. Nov 01, 2000

Statin administration in animals results in a myopathy characterized by decreased muscle force and elevated plasma CK level.Nov 09, 2011

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Creatine Phosphokinase (CK): Elevated

View the Evidence:
10 Abstracts with Creatine Phosphokinase (CK): Elevated Research