Degenerative Disk Disease

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49 Substances Researched for Degenerative Disk Disease
NameACCKFocus
Vitamin B12: methylcobalamin 110Locked
Flavonoids58Locked
Panax Notoginseng36Locked
Andrographolide25Locked
Curcumin35Locked
Ginsenosides45Locked
Sinomenine25Locked
Honokiol24Locked
Icariin34Locked
Resveratrol34Locked
Salvia miltiorrhiza24Locked
Urolithin A 24Locked
Vitamin C34Locked
Andrographis13Locked
Berberine33Locked
Citrus Triterpenoids13Locked
Cyanidin23Locked
Cannabidiol12Locked
Fisetin12Locked
Fucoxanthin 12Locked
Ginkgo biloba22Locked
Goji12Locked
Hydroxytyrosol12Locked
Ligustrazine12Locked
Melatonin12Locked
Myricetin22Locked
Puerarin12Locked
Sesamin12Locked
Sophora Flavescens12Locked
Tomatidine 12Locked
Wogonin12Locked
Allicin11Locked
Astragaloside11Locked
Butyrate11Locked
Chondroitin Sulfate11Locked
Chrysin11Locked
Cordyceps Militaris11Locked
Curcumol11Locked
EGCG (Epigallocatechin gallate)11Locked
Genistein11Locked
Glucosamine11Locked
Glycyrrhizin11Locked
Kaempferol11Locked
Lycopene11Locked
Nordihydroguaiaretic acid (NDGA)11Locked
Procyanidin B2 11Locked
Reishi Mushroom11Locked
Safflower11Locked
Sulforaphane11Locked
2 Therapeutic Actions Researched for Degenerative Disk Disease
NameACCKFocus
Photobiomodulation826Locked
Sunlight Exposure: UVB Light12Locked

View the Evidence:
83 Abstracts with Degenerative Disk Disease Research

[+]

Biological non-ablative repair of lumbar discs by transforaminal intradiscal laser irradiation: MRI quantitative analysis of the effects-preliminary report.Jan 31, 2022

Pubmed Data : Lasers Med Sci. 2022 Feb ;37(1):155-162. Epub 2020 Nov 12. PMID: 33180214
Article Published Date : Jan 31, 2022
Study Type : Human Study
Additional Links
Diseases : Degenerative Disk Disease, Low Back Pain
Therapeutic Actions : Photobiomodulation
Additional Keywords : Cartilage Regeneration
[+]

Laser biostimulation can be an effective strategy in the therapy of the invertebral disks.Dec 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Laser Ther. 2016 Dec 30 ;25(4):285-290. PMID: 28765673
Article Published Date : Dec 29, 2016
Study Type : Human Study
Additional Links
Diseases : Degenerative Disk Disease
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Chondroprotective
[+]

Methylcobalmin improves neurogenic claudication distance in patients with lumbar spinal stenosis. Aug 01, 2000

Pubmed Data : J Med Assoc Thai. 2000 Aug;83(8):825-31. PMID: 10998833
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Substances : Vitamin B12: methylcobalamin
Diseases : Degenerative Disk Disease, Neurogenic Claudication , Spinal Stenosis
[+]

Andrographolide inhibits static mechanical pressure-induced intervertebral disc degeneration.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2023 ;17:535-550. Epub 2023 Feb 20. PMID: 36845666
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Limonin delays the progression of intervertebral disc degeneration.Apr 16, 2023

Pubmed Data : J Pharm Pharmacol. 2023 Apr 17 ;75(5):612-624. PMID: 36856818
Article Published Date : Apr 16, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus Triterpenoids
Diseases : Degenerative Disk Disease, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Panax notoginseng saponins inhibits oxidative stress- induced human nucleus pulposus cell apoptosis and delays disc degeneration.Sep 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2023 Sep 15 ;319(Pt 1):117166. Epub 2023 Sep 15. PMID: 37716491
Article Published Date : Sep 14, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Panax Notoginseng
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Autophagy Inhibitors
[+]

Sinomenine ameliorates IL-1β-induced intervertebral disc degeneration.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2023 ;16:4777-4791. Epub 2023 Oct 20. PMID: 37881650
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sinomenine
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Acacetin alleviates inflammation and matrix degradation in nucleus pulposus cells and ameliorates intervertebral disc degeneration.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:4801-4813. Epub 2020 Nov 10. PMID: 33204066
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Degenerative Disk Disease, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Superoxide Dismutase Up-regulation
[+]

Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure.Jun 04, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2024 Jun 5 ;70(6):192-198. Epub 2024 Jun 5. PMID: 38836662
Article Published Date : Jun 04, 2024
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Degenerative Disk Disease, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidant, Autophagy Up-regulation
[+]

Ascorbic acid promotes nucleus pulposus cell regeneration by regulating proliferation during intervertebral disc degeneration.Jun 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Biochem. 2022 Jun 29:109099. Epub 2022 Jun 29. PMID: 35779794
Article Published Date : Jun 28, 2022
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Degenerative Disk Disease
Additional Keywords : Bone Regeneration, Gene Expression Regulation
[+]

Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture and could be useful in the treatment of intervertebral disc degeneration.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(12):e113161. Epub 2014 Dec 17. PMID: 25517414
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Degenerative Disk Disease
[+]

Curcumin may decelerate the process of lumbar intervertebral disc degeneration.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2015 Apr ;19(7):1305-14. PMID: 25912594
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Degenerative Disk Disease
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis.Mar 18, 2025

Pubmed Data : J Mol Histol. 2025 Mar 19 ;56(2):111. Epub 2025 Mar 19. PMID: 40106034
Article Published Date : Mar 18, 2025
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Chondroprotective
[+]

Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):427-436. PMID: 35175176
Article Published Date : Nov 30, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cyanidin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic
[+]

Effects of puerarin on the intervertebral disc degeneration and biological characteristics of nucleus pulposus cells.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2023 Dec ;61(1):12-22. PMID: 36524765
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Degenerative Disk Disease, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, NF-kappaB Inhibitor
[+]

Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration.Feb 04, 2024

Pubmed Data : Eur J Pharmacol. 2024 Feb 5 ;964:176298. Epub 2023 Dec 23. PMID: 38145645
Article Published Date : Feb 04, 2024
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration.Nov 01, 2023

Pubmed Data : Phytother Res. 2023 Nov 2. Epub 2023 Nov 2. PMID: 37918392
Article Published Date : Nov 01, 2023
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Degenerative Disk Disease
Pharmacological Actions : SIRT1 Activator
[+]

Genkwanin alleviates intervertebral disc degeneration.May 29, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2024 May 30 ;133:112101. Epub 2024 Apr 18. PMID: 38640717
Article Published Date : May 29, 2024
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Ginsenoside Rg3 exhibits anti-catabolic and anti-apoptotic effects in IL-1β treated human disc nucleus pulposus cells and in a rat model of disc degeneration.Jan 30, 2024

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2024 Jan 31 ;70(1):233-238. Epub 2024 Jan 31. PMID: 38372089
Article Published Date : Jan 30, 2024
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Honokiol alleviates the degeneration of intervertebral disc.May 19, 2018

Pubmed Data : Free Radic Biol Med. 2018 May 20 ;120:368-379. Epub 2018 Apr 9. PMID: 29649568
Article Published Date : May 19, 2018
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor
[+]

Honokiol is a potential candidate for the treatment of intervertebral disc degeneration.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anal Sci. 2015 ;31(12):1297-302. PMID: 26656821
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Degenerative Disk Disease
Additional Keywords : Dose Response
[+]

Hydroxytyrosol ameliorates intervertebral disc degeneration and neuropathic pain.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:2240894. Epub 2022 Nov 2. PMID: 36388163
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hydroxytyrosol
Diseases : Degenerative Disk Disease, Inflammation, Neuropathic Pain, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:937502. Epub 2022 Sep 13. PMID: 36176424
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants, Chondroprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Isorhamnetin inhibits mechanical stress-induced chondrocyte apoptosis.Jan 12, 2026

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2026 Jan 13 ;16(1):5106. Epub 2026 Jan 13. PMID: 41530364
Article Published Date : Jan 12, 2026
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Chondroprotective
[+]

Ligustrazine prevents intervertebral disc degeneration.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:5601734. Epub 2019 Dec 2. PMID: 31886227
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Degenerative Disk Disease
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

Lycium barbarum alleviates oxidative stress-induced ferroptosis and enhances mitophagy in intervertebral disc degeneration.Sep 05, 2025

Pubmed Data : Cell Signal. 2025 Sep 6 ;136:112114. Epub 2025 Sep 6. PMID: 40921308
Article Published Date : Sep 05, 2025
Study Type : Animal Study
Additional Links
Substances : Goji
Diseases : Degenerative Disk Disease
[+]

Melatonin protects intervertebral disc from degeneration.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:5120275. Epub 2019 Dec 2. PMID: 31885798
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic
[+]

Narrowband ultraviolet B radiation attenuates nucleus pulposus pyroptosis to ameliorate intervertebral disc degeneration.Dec 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2025 ;16:1663674. Epub 2025 Oct 22. PMID: 41200164
Article Published Date : Dec 31, 2024
Study Type : Animal Study
Additional Links
Diseases : Degenerative Disk Disease
Therapeutic Actions : Sunlight Exposure: UVB Light
Pharmacological Actions : Antioxidants
[+]

Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Biol Med (Maywood). 2020 Mar ;245(6):532-541. Epub 2020 Jan 24. PMID: 31979980
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Sophora Flavescens
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JOR Spine. 2021 Dec ;4(4):e1182. Epub 2021 Nov 30. PMID: 35005448
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Degenerative Disk Disease
Pharmacological Actions : Osteoprotective
[+]

Resveratrols anabolic effects on degenerated discs indicate that it is a promising candidate for treatment of degenerative disc disease.May 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Korean Med Sci. 2013 Jun ;28(6):939-45. Epub 2013 Jun 3. PMID: 23772162
Article Published Date : May 31, 2013
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anabolic Agents, Matrix Metalloproteinase-13 (MMP-13) Inhibitor
[+]

Salvianolic acid A contributes to cartilage endplate cell restoration by regulating miR-940 and miR-576-5p.Oct 24, 2023

Pubmed Data : Zhongguo Gu Shang. 2023 Oct 25 ;36(10):982-9. PMID: 37881933
Article Published Date : Oct 24, 2023
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Chondroprotective, Interleukin-1 beta downregulation
[+]

Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.Jan 25, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2024 Jan 26 ;16(2):1145-1160. Epub 2024 Jan 26. PMID: 38284902
Article Published Date : Jan 25, 2024
Study Type : Animal Study
Additional Links
Substances : Sesamin
Diseases : Degenerative Disk Disease, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Inhibitors
[+]

Sinomenine ameliorates intervertebral disc degeneration.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(9):5956-5966. Epub 2019 Sep 15. PMID: 31632563
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sinomenine
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors
[+]

Sodium Tanshinone IIA sulfonate ameliorates injury-induced oxidative stress and intervertebral disc degeneration.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:5556122. Epub 2021 May 25. PMID: 34122723
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Degenerative Disk Disease, Oxidative Stress
Pharmacological Actions : Antioxidants, Chondroprotective
[+]

Tomatidine alleviates intervertebral disc degeneration.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2024 ;18:6313-6329. Epub 2024 Dec 27. PMID: 39741916
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Tomatidine
Diseases : Degenerative Disk Disease, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Urolithin A may be a useful therapeutic agent for the treatment of Intervertebral disc degeneration.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1043. Epub 2018 Sep 18. PMID: 30283339
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration.Feb 23, 2020

Pubmed Data : Free Radic Biol Med. 2020 Feb 24 ;150:109-119. Epub 2020 Feb 24. PMID: 32105828
Article Published Date : Feb 23, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic
[+]

Wogonin mitigates intervertebral disc degeneration.Nov 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Dec ;65:539-549. Epub 2018 Nov 6. PMID: 30412851
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation
[+]

Allicin could be a promising therapeutic approach against AOPP-mediated oxidative stress during Intervertebral disc degeneration progression.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:6685043. Epub 2020 Dec 14. PMID: 33381267
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Allicin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants
[+]

Antioxidant effects of resveratrol in intervertebral disk Oct 19, 2021

Pubmed Data : J Invest Surg. 2021 Oct 20:1-10. Epub 2021 Oct 20. PMID: 34670455
Article Published Date : Oct 19, 2021
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants
[+]

Astragaloside IV relieves IL-1β-induced human nucleus pulposus cells degeneration.Aug 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2023 Aug 18 ;102(33):e34815. PMID: 37603510
Article Published Date : Aug 17, 2023
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Berberine prevents human nucleus pulposus cells from IL‑1β‑induced extracellular matrix degradation and apoptosis.Feb 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2019 Feb 21. Epub 2019 Feb 21. PMID: 30816449
Article Published Date : Feb 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Berberine suppresses apoptosis and extracellular matrix degradation in nucleus pulposus cells and ameliorates disc degeneration.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2018 ;14(6):682-692. Epub 2018 Apr 30. PMID: 29904282
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Degenerative Disk Disease
[+]

Butyrate alleviates inflammatory response and NF-κB activation in human degenerated intervertebral disc tissues.Nov 24, 2019

Pubmed Data : Int Immunopharmacol. 2019 Nov 25:106004. Epub 2019 Nov 25. PMID: 31780370
Article Published Date : Nov 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Chrysin attenuates intervertebral disk degeneration.Dec 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2025 ;12:1593317. Epub 2025 May 12. PMID: 40421294
Article Published Date : Dec 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Cordycepin may be a potential treatment for intervertebral disc degeneration in the future.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2016 ;4:e1992. Epub 2016 May 10. PMID: 27190710
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Curcumin prevents tension-induced endplate cartilage degeneration by enhancing autophagy.Sep 30, 2020

Pubmed Data : Life Sci. 2020 Oct 1 ;258:118213. Epub 2020 Aug 5. PMID: 32768583
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Chondroprotective
[+]

Curcumol alleviates the inflammation of nucleus pulposus cells via the PI3K/Akt/NF-κB signaling pathway and delays intervertebral disk degeneration.Aug 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World Neurosurg. 2021 Aug 24. Epub 2021 Aug 24. PMID: 34450323
Article Published Date : Aug 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling.Dec 27, 2021

Pubmed Data : J Appl Toxicol. 2021 Dec 28. Epub 2021 Dec 28. PMID: 34964128
Article Published Date : Dec 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Cyanidin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nrf2 activation
[+]

Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients.Jun 14, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Jun 15 ;10(1):9655. Epub 2020 Jun 15. PMID: 32541845
Article Published Date : Jun 14, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Degenerative Disk Disease
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Galangin alleviates intervertebral disc degeneration.Oct 14, 2025

Pubmed Data : J Agric Food Chem. 2025 Oct 15 ;73(41):26060-26072. Epub 2025 Oct 3. PMID: 41043107
Article Published Date : Oct 14, 2025
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Ganoderic Acid A alleviates the degeneration of intervertebral disc.Apr 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2022 May ;13(5):11684-11693. PMID: 35506157
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chondroprotective
[+]

Ginkgetin alleviates intervertebral disc degeneration.Oct 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Immunol Invest. 2023 Nov ;52(5):546-560. Epub 2023 May 8. PMID: 37154418
Article Published Date : Oct 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Degenerative Disk Disease, Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2019 ;52(9):e8525. Epub 2019 Aug 12. PMID: 31411316
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Ginsenoside Rg3 may exert the effect of attenuating TNF-α-induced nucleus pulposus cells impairment via blocking the NF-κB signalling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2019 Jan 1 ;216:1-9. Epub 2018 Nov 11. PMID: 30428306
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Glucosamine and chondroitin sulfate may treat symptomatic spinal disc degeneration. Jun 10, 2003

Pubmed Data : 1:BMC Complement Altern Med.2003 Jun 10;3:2. Epub 2003 Jun 10 PMID: 12797867
Article Published Date : Jun 10, 2003
Study Type : Commentary
Additional Links
Substances : Chondroitin Sulfate, Glucosamine
Diseases : Degenerative Disk Disease
Additional Keywords : Regenerative Substances
[+]

Glycyrrhizin may become a novel cytokine for the therapy of intervertebral disc degeneration in the future.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(8):5105-5113. Epub 2019 Aug 15. PMID: 31497226
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII.Jan 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2022 Feb ;23(2):182. Epub 2021 Dec 30. PMID: 35069863
Article Published Date : Jan 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Degenerative Disk Disease, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Matrix Metalloproteinase-13 (MMP-13) Inhibitor
[+]

Hyperoside ameliorates TNF‑α‑induced inflammation.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2022 Aug ;26(2). Epub 2022 Jun 22. PMID: 35730622
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin regulates stem cell migration for endogenous repair of intervertebral disc degeneration.Mar 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2022 Mar 10 ;22(1):63. Epub 2022 Mar 10. PMID: 35272637
Article Published Date : Mar 09, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Chondroprotective
[+]

Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration.Mar 20, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nanobiotechnology. 2023 Mar 21 ;21(1):99. Epub 2023 Mar 21. PMID: 36941611
Article Published Date : Mar 20, 2023
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation
[+]

Kaempferol may serve as a novel target for treatment of Intervertebral disc degeneration.Dec 29, 2016

Pubmed Data : Int Immunopharmacol. 2016 Dec 30 ;43:236-242. Epub 2016 Dec 30. PMID: 28043032
Article Published Date : Dec 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation
[+]

Low level light therapy modulates inflammatory mediators secreted by human annulus fibrosus cells during intervertebral disc degeneration in vitro.Dec 31, 2014

Pubmed Data : Photochem Photobiol. 2015 ;91(2):403-10. Epub 2015 Jan 26. PMID: 25557915
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Diseases : Degenerative Disk Disease, Inflammation
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway.Mar 05, 2020

Pubmed Data : Mol Cell Probes. 2020 Mar 6:101559. Epub 2020 Mar 6. PMID: 32151764
Article Published Date : Mar 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Myricetin protects against rat intervertebral disc degeneration.Jul 27, 2023

Pubmed Data : Biochem Genet. 2023 Jul 28. Epub 2023 Jul 28. PMID: 37507641
Article Published Date : Jul 27, 2023
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Osteoprotective
[+]

Myricetin restores autophagy to attenuate lumbar intervertebral disk degeneration.Jun 05, 2024

Pubmed Data : Biochem Genet. 2024 Jun 6. Epub 2024 Jun 6. PMID: 38842745
Article Published Date : Jun 05, 2024
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Chondroprotective
[+]

Nordihydroguaiaretic acid suppresses ferroptosis and mitigates intervertebral disc degeneration.Dec 24, 2024

Pubmed Data : Int Immunopharmacol. 2024 Dec 25 ;143(Pt 3):113590. Epub 2024 Nov 15. PMID: 39541847
Article Published Date : Dec 24, 2024
Study Type : In Vitro Study
Additional Links
Substances : Nordihydroguaiaretic acid (NDGA)
Diseases : Degenerative Disk Disease, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Nrf2 activation
[+]

Notoginsenoside R1 suppresses inflammatory response and the pyroptosis of nucleus pulposus cells.Nov 30, 2021

Pubmed Data : Int Immunopharmacol. 2021 Dec ;101(Pt B):107866. Epub 2021 Sep 26. PMID: 34588155
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Degenerative Disk Disease, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Panax notoginseng saponin reduces IL-1β-stimulated apoptosis and endoplasmic reticulum stress of nucleus pulposus cells.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2022 Jul ;10(13):748. PMID: 35957710
Article Published Date : Jun 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Panax Notoginseng
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, MicroRNA modulator
[+]

Photobiomodulation of extracellular matrix enzymes in human nucleus pulposus cells as a potential treatment for intervertebral disk degeneration.Aug 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Aug 3 ;8(1):11654. Epub 2018 Aug 3. PMID: 30076336
Article Published Date : Aug 02, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Degenerative Disk Disease
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Chondroprotective
[+]

Photobiomodulation on human annulus fibrosus cells during the intervertebral disk degeneration: extracellular matrix-modifying enzymes.Apr 30, 2016

Pubmed Data : Lasers Med Sci. 2016 May ;31(4):767-77. Epub 2016 Mar 17. PMID: 26987527
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Degenerative Disk Disease
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Phototherapy suppresses inflammation in human nucleus pulposus cells for intervertebral disc degeneration.Jun 30, 2018

Pubmed Data : Lasers Med Sci. 2018 Jul ;33(5):1055-1064. Epub 2018 Mar 3. PMID: 29502159
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Degenerative Disk Disease, Inflammation
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Procyanidin B2 alleviates oxidative stress-induced nucleus pulposus cells apoptosis.Nov 28, 2022

Pubmed Data : J Orthop Res. 2022 Nov 29. Epub 2022 Nov 29. PMID: 36448180
Article Published Date : Nov 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Procyanidin B2
Diseases : Degenerative Disk Disease, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation
[+]

Resveratrol my slow the progression of interverterbral disc degeneration. Nov 15, 2008

Pubmed Data : Spine. 2008 Nov 15;33(24):2586-95. PMID: 19011540
Article Published Date : Nov 15, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Degenerative Disk Disease
[+]

Sulforaphane delays intervertebral disc degenerationDec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:3626091. Epub 2023 Jan 7. PMID: 36647429
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

The impact of photobiomodulation on the chondrogenic potential of adipose-derived stromal/stem cells.Jul 31, 2021

Pubmed Data : J Photochem Photobiol B. 2021 Aug ;221:112243. Epub 2021 Jun 18. PMID: 34217028
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Degenerative Disk Disease
Therapeutic Actions : Photobiomodulation
Additional Keywords : Cartilage Regeneration
[+]

The natural polyphenol epigallocatechin gallate protects intervertebral disc cells from oxidative stress.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:7031397. Epub 2016 Mar 28. PMID: 27119009
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Degenerative Disk Disease, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

The protective activity of genistein against bone and cartilage diseases.Dec 31, 2021

Pubmed Data : Front Pharmacol. 2022 ;13:1016981. Epub 2022 Sep 8. PMID: 36160403
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Genistein
Diseases : Degenerative Disk Disease, Osteoarthritis, Osteoporosis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Therapeutic mechanisms of icariin in intervertebral disc degeneration.May 31, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2025 Jun ;42:102047. Epub 2025 May 15. PMID: 40486496
Article Published Date : May 31, 2025
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

This study suggests berberine might function as an AMPK activator to alleviate intervertebral disc degeneration progression.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:6133629. Epub 2022 Jul 23. PMID: 35915801
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Interleukin-1 beta downregulation
[+]

Vitamin C deficiency is an under-diagnosed contributor to degenerative disc disease in the elderly.Mar 31, 2010

Pubmed Data : Med Hypotheses. 2010 Apr ;74(4):695-7. Epub 2009 Nov 22. PMID: 19932568
Article Published Date : Mar 31, 2010
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Degenerative Disk Disease, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Vitamin C reduces cartilage degeneration induced by static-load challenges. Oct 01, 2008

Pubmed Data : Cell Tissue Res. 2008 Oct;334(1):111-20. Epub 2008 Aug 5. PMID: 18679720
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Cartilage Diseases, Degenerative Disk Disease

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