Depressive Disorder

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45 Substances Researched for Depressive Disorder
NameACCKFocus
Vitamin D660Locked
Fruit: All550Locked
Vegetables: All 550Locked
Curcumin544Locked
Probiotics422Locked
Docosahexaenoic acid (DHA)120Locked
Eicosapentaenoic acid (EPA) 120Locked
Melatonin220Locked
Saffron312Locked
Bifidobacterium Bifidum110Locked
Calcium110Locked
Chlorella (Algae)110Locked
EPA (Eicosapentaenoic Acid)110Locked
Fiber110Locked
Green Leafy Vegetables110Locked
Green Tea110Locked
Iron 110Locked
Lactobacillus casei110Locked
Magnesium110Locked
Mushrooms: All 110Locked
NAC (N-acetyl-L-cysteine)110Locked
Phosphatidylserine110Locked
Piperidines110Locked
Potatoes110Locked
Rhodiola (Tibetan Ginseng)110Locked
Rose 110Locked
S-Adenosylmethionine (SAMe)110Locked
Seaweed110Locked
Theanine110Locked
Tyrosine110Locked
Zinc110Locked
Astragaloside12Locked
Broccoli Sprouts12Locked
Cannabinoids 12Locked
Dandelion 12Locked
Ferulic acid12Locked
Nettle12Locked
Piperine12Locked
Sulforaphane12Locked
Water: Deuterium Depleted12Locked
Folic Acid 11Locked
Huperzine11Locked
Psychedelics:All 11Locked
Salvia divinorum11Locked
Vitamin C11Locked
7 Problem Substances Researched for Depressive Disorder
NameACCKFocus
Fluoxetine (trade name Prozac) 220Locked
Selective Serotonin Reuptake Inhibitors (SSRIs)110Locked
Sertraline110Locked
Sugar Sweetened Beverages110Locked
Sugary soda110Locked
Dexamethasone12Locked
Gluten11Locked
16 Therapeutic Actions Researched for Depressive Disorder
NameACCKFocus
Yoga431Locked
Light Therapy330Locked
Mindfullness Training230Locked
Exercise422Locked
Acupuncture220Locked
Mind-Body Therapies120Locked
Qigong120Locked
Electroacupuncture212Locked
Dietary Modification: Mediterranean Diet110Locked
Floatation Tank Immersion110Locked
Infrared Light110Locked
Integrative Medicine110Locked
Laser Treatment: Low-Level110Locked
Relaxation Therapy 110Locked
Spiritual Beliefs110Locked
Therapeutic Breathing110Locked
2 Problematic Actions Researched for Depressive Disorder
NameACCKFocus
Vaccination: All110Locked
Western Diet110Locked

View the Evidence:
90 Abstracts with Depressive Disorder Research

[+]

Curcumin administration reduces depressive symptoms in patients with major depression.Nov 26, 2015

Pubmed Data : Phytother Res. 2015 Nov 27. Epub 2015 Nov 27. PMID: 26610378
Article Published Date : Nov 26, 2015
Study Type : Meta Analysis
Additional Links
Substances : Curcumin
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Significant Treatment Outcome
[+]

Qigong-based exercises may be effective for alleviating depression symptoms in individuals with major depressive disorder.Jan 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2019 03 7 ;16(5). Epub 2019 Mar 7. PMID: 30866431
Article Published Date : Jan 06, 2019
Study Type : Meta Analysis
Additional Links
Diseases : Depression, Depressive Disorder
Therapeutic Actions : Qigong
Pharmacological Actions : Antidepressive Agents
[+]

The use of evidence-based mind-body therapies can alleviate depression severity.Aug 13, 2012

Pubmed Data : Psychosomatics. 2012 Aug 14. Epub 2012 Aug 14. PMID: 22902090
Article Published Date : Aug 13, 2012
Study Type : Meta Analysis
Additional Links
Diseases : Depressive Disorder, Fibromyalgia
Therapeutic Actions : Mind-Body Therapies, Mindfullness Training
[+]

These results indicate a beneficial effect of the combination of EPA and DHA on depressed mood in women compared with placebo. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychiatr Dis Treat. 2015 ;11:2055-61. Epub 2015 Aug 10. PMID: 26300645
Article Published Date : Dec 31, 2014
Study Type : Meta Analysis
Additional Links
Substances : Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA)
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
[+]

A 12-week yoga program was effective in increasing parasympathetic tone and reducing depressive symptoms and perceived stress in women.Jan 03, 2017

Pubmed Data : J Altern Complement Med. 2017 Jan 4. Epub 2017 Jan 4. PMID: 28051319
Article Published Date : Jan 03, 2017
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Yoga
Pharmacological Actions : Antidepressive Agents
[+]

A 4-week training of aerobic exercise significantly improves functional capacity in patients with major depressive disorder.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0154195. Epub 2016 May 6. PMID: 27152523
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Depression, Depressive Disorder
Therapeutic Actions : Exercise
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Medication Reduction
[+]

A Mediterranean dietary pattern protects against depressive disorders. Oct 01, 2009

Pubmed Data : Arch Gen Psychiatry. 2009 Oct;66(10):1090-8. PMID: 19805699
Article Published Date : Oct 01, 2009
Study Type : Human Study
Additional Links
Diseases : Depression, Depressive Disorder
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

A recent trial spotlights bright light therapy and its utility beyond the winter months in treating major depressive disorder.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Fam Pract. 2016 Jul ;65(7):486-8. PMID: 27565102
Article Published Date : Jun 30, 2016
Study Type : Human: Case Report, Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Light Therapy
Pharmacological Actions : Antidepressive Agents
[+]

AGE accumulation in the skin is independently associated with higher levels of depressive symptoms and depressive disorder.Jun 05, 2016

Pubmed Data : Depress Anxiety. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27271340
Article Published Date : Jun 05, 2016
Study Type : Human Study
Additional Links
Diseases : Advanced Glycation End products (AGE), Depression, Depressive Disorder
Additional Keywords : Increased Risk
[+]

An augmentation study of MSI-195 (S-adenosylmethionine) in major depressive disorder.Nov 30, 2018

Pubmed Data : J Psychiatr Res. 2018 Dec ;107:86-96. Epub 2018 Oct 18. PMID: 30368163
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Substances : S-Adenosylmethionine (SAMe)
Diseases : Depressive Disorder
Pharmacological Actions : Antidepressive Agents
[+]

Bright light therapy was also more efficacious than placebo in the population of patients with drug-resistant depression.Sep 30, 2016

Pubmed Data : J Affect Disord. 2016 Oct ;203:1-8. Epub 2016 Aug 26. PMID: 27267951
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Light Therapy
Pharmacological Actions : Antidepressive Agents
[+]

Bright light treatment in elderly patients with major depressive disorder improved mood, enhanced sleep efficiency and increased melatonin level.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Gen Psychiatry. 2011 Jan ;68(1):61-70. PMID: 21199966
Article Published Date : Dec 31, 2010
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Depressive Disorder
Therapeutic Actions : Light Therapy
Pharmacological Actions : Antidepressive Agents
[+]

Combining therapeutic acupuncture with structured salutogenic dialogue appears to have greater intermediate-term effects than usual primary care in reducing anxiety and depression.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:210. Epub 2014 Jun 30. PMID: 24980440
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Depression, Depressive Disorder, Psychological Distress
Therapeutic Actions : Acupuncture, Integrative Medicine
[+]

Curcumin was significantly more effective than placebo in improving several mood related symptoms in this study. Dec 31, 2013

Pubmed Data : J Affect Disord. 2014 ;167:368-75. Epub 2014 Jun 11. PMID: 25046624
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Significant Treatment Outcome
[+]

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Pubmed Data : Phytother Res. 2015 Jan ;29(1):17-21. Epub 2014 Aug 4. PMID: 25091591
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Curcumin, Piperidines
Diseases : Anxiety Disorders, Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Dietary glycaemic index and fibre intakes and consumption of fruits and vegetables are associated with lower depressive symptoms.Nov 30, 2016

Pubmed Data : Br J Nutr. 2016 Dec ;116(12):2109-2114. Epub 2017 Jan 9. PMID: 28065177
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Substances : Fiber, Fruit: All, Vegetables: All
Diseases : Depressive Disorder
Additional Keywords : Risk Reduction
[+]

Effect of electroacupuncture on mice model of permenopausal depressive disorder.Nov 30, 2019

Pubmed Data : Saudi J Biol Sci. 2019 Dec ;26(8):2030-2036. Epub 2019 Aug 9. PMID: 31885488
Article Published Date : Nov 30, 2019
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder, Postmenopausal Disorders
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antidepressive Agents
[+]

Flotation therapy helped relieve participants stress, anxiety, depression and relief from long lasting pain, while increasing sleep quality and optimism levels. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:417. Epub 2014 Oct 25. PMID: 25344737
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Chronic Pain, Depression, Depressive Disorder, Sleep Disorders, Stress
Therapeutic Actions : Floatation Tank Immersion, Relaxation Therapy
Additional Keywords : Altered States Of Consciousness, Significant Treatment Outcome
[+]

Frequent consumption of both soda and fruit drinks is associated with greater depressive symptoms among adolescents.Jul 12, 2016

Pubmed Data : Public Health Nutr. 2016 Jul 13:1-8. Epub 2016 Jul 13. PMID: 27406952
Article Published Date : Jul 12, 2016
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Additional Keywords : Increased Risk
Problem Substances : Sugar Sweetened Beverages, Sugary soda
[+]

Fruit and vegetable intake and physical activity helps to reduce depressive symptoms.May 24, 2017

Pubmed Data : J Affect Disord. 2017 May 25 ;220:31-37. Epub 2017 May 25. PMID: 28577427
Article Published Date : May 24, 2017
Study Type : Human Study
Additional Links
Substances : Fruit: All, Green Leafy Vegetables, Vegetables: All
Diseases : Depressive Disorder
Therapeutic Actions : Exercise
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Physical Activity
[+]

Fruit and vegetable intake moderated the association between depressive symptoms and cigarette smoking.Apr 18, 2016

Pubmed Data : Subst Abus. 2016 Apr 19:1-8. Epub 2016 Aug 19. PMID: 27093192
Article Published Date : Apr 18, 2016
Study Type : Human Study
Additional Links
Substances : Fruit: All, Vegetables: All
Diseases : Depressive Disorder, Smoking
Additional Keywords : Risk Factors, Risk Reduction
[+]

Higher dietary intake of magnesium, calcium, iron, and zinc is associated with lower prevalence of depressive symptoms in Japanese employees.Apr 30, 2015

Pubmed Data : Nutrition. 2015 May ;31(5):686-90. Epub 2014 Dec 3. PMID: 25837213
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Calcium, Iron , Magnesium, Zinc
Diseases : Depressive Disorder
Additional Keywords : Risk Reduction
[+]

Higher spiritual involvement is associated with more positive emotions, a finding which may influence the course of depression over time.Jul 31, 2014

Pubmed Data : J Psychosom Res. 2014 Aug ;77(2):135-43. Epub 2014 May 15. PMID: 25077855
Article Published Date : Jul 31, 2014
Study Type : Human Study
Additional Links
Diseases : Chronic Disease, Depression, Depressive Disorder
Therapeutic Actions : Spiritual Beliefs
[+]

Increasing fruit consumption may be one important factor for reducing both the prevalence and incidence of depressive symptoms in mid-age women.Apr 30, 2015

Pubmed Data : Eur J Clin Nutr. 2015 May ;69(5):585-91. Epub 2014 Oct 29. PMID: 25351653
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Fruit: All, Vegetables: All
Diseases : Depressive Disorder
Additional Keywords : Risk Reduction
[+]

Individuals with lower bacterial counts for Bifidobacterium or Lactobacillus are more common in patients with major depressive disorders.May 31, 2016

Pubmed Data : Brain Nerve. 2016 Jun ;68(6):641-6. PMID: 27279162
Article Published Date : May 31, 2016
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder, Dysbiosis, Dysbiosis: Bifidobacteria Deficiency
Additional Keywords : Gut-brain Axis, Microbiota
[+]

Inflammation may influence glutamate metabolism to alter behaviour, leading to depressive symptoms.Nov 09, 2016

Pubmed Data : Curr Top Behav Neurosci. 2016 Nov 10. Epub 2016 Aug 10. PMID: 27830574
Article Published Date : Nov 09, 2016
Study Type : Human Study
Additional Links
Diseases : Brain Inflammation , Depressive Disorder, Inflammation
Additional Keywords : Risk Factors
[+]

l-theanine has multiple beneficial effects on depressive symptoms, anxiety, sleep disturbance and cognitive impairments in patients with MDD.Jul 10, 2016

Pubmed Data : Acta Neuropsychiatr. 2016 Jul 11:1-8. Epub 2016 Jul 11. PMID: 27396868
Article Published Date : Jul 10, 2016
Study Type : Human Study
Additional Links
Substances : Theanine
Diseases : Anxiety, Depressive Disorder
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Low serum 25(OH)D was associated with higher depressive symptom scores.Jul 03, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2015 Jul 4. Epub 2015 Jul 4. PMID: 26141257
Article Published Date : Jul 03, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Depression, Depressive Disorder, Vitamin D Deficiency
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Gene Expression, Risk Reduction
[+]

Low vitamin D status is associated with abnormal female sexual functioning, the severity of which depends on the degree of vitamin D deficiency.Aug 08, 2016

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2016 Aug 9 ;204:108-112. Epub 2016 Aug 9. PMID: 27544743
Article Published Date : Aug 08, 2016
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder, Sexual Arousal Disorder, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

Phosphatidylserine induces consistent improvement of depressive symptoms, memory and behaviour in geriatric patients with depressive disorders.. Mar 01, 1990

Pubmed Data : Acta Psychiatr Scand. 1990 Mar;81(3):265-70. PMID: 1693032
Article Published Date : Mar 01, 1990
Study Type : Human Study
Additional Links
Substances : Phosphatidylserine
Diseases : Depressive Disorder, Memory Loss
[+]

Plasma vitamin D might have a preventive role against recurrent depressive symptoms.Jul 26, 2016

Pubmed Data : Eur J Nutr. 2016 Jul 27. Epub 2016 Jul 27. PMID: 27464883
Article Published Date : Jul 26, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Depression, Depressive Disorder, Vitamin D Deficiency
[+]

Probiotic administration in patients with major depressive disorder for 8 weeks had beneficial effects on beck depression Inventory.Sep 27, 2015

Pubmed Data : Nutrition. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26706022
Article Published Date : Sep 27, 2015
Study Type : Human Study
Additional Links
Substances : Bifidobacterium Bifidum, Lactobacillus casei, Probiotics
Diseases : C-Reactive Protein, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
[+]

R. rosea, although less effective than sertraline, may possess a more favorable risk to benefit ratio for individuals with mild to moderate depression.Mar 14, 2015

Pubmed Data : Phytomedicine. 2015 Mar 15 ;22(3):394-9. Epub 2015 Feb 23. PMID: 25837277
Article Published Date : Mar 14, 2015
Study Type : Human Study
Additional Links
Substances : Rhodiola (Tibetan Ginseng)
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Sertraline
[+]

Results suggest that adherence to a diet rich in vegetables, fruits, and typical Japanese foods is associated with a lower probability of having depressive symptoms.Jul 14, 2015

Pubmed Data : Psychiatry Res. 2015 Jul 15. Epub 2015 Jul 15. PMID: 26208984
Article Published Date : Jul 14, 2015
Study Type : Human Study
Additional Links
Substances : Fruit: All, Green Tea, Mushrooms: All , Potatoes, Seaweed, Vegetables: All
Diseases : Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
[+]

Results support for the first time an association between seropositivity to T. gondii and mixed anxiety and depressive disorder.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med Res. 2016 Jul ;8(7):519-23. Epub 2016 May 29. PMID: 27298660
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Depressive Disorder, Toxoplasma gondii Infection
Additional Keywords : Increased Risk
[+]

Rosa damascena oil improved sexual function in male patients suffering from both major depressive disorders and SSRI-induced sexual dysfunction.Jun 30, 2015

Pubmed Data : Pharmacopsychiatry. 2015 Jul ;48(4-5):156-63. Epub 2015 Jun 22. PMID: 26098128
Article Published Date : Jun 30, 2015
Study Type : Human Study
Additional Links
Substances : Rose
Diseases : Depressive Disorder, Sexual Dysfunction: SSRI-induced
Additional Keywords : Plant Extracts
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Saffron capsules showed the same antidepressant efficacy compared with fluoxetine in patients with a prior history of PCI who were suffering from depression.Jan 31, 2014

Pubmed Data : J Affect Disord. 2014 Feb ;155:216-22. Epub 2013 Nov 16. PMID: 24289892
Article Published Date : Jan 31, 2014
Study Type : Human Study
Additional Links
Substances : Saffron
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substances Versus Drugs, Phytotherapy, Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Supplementation for six week with chlorella vulgaris extract improved anxiety, physical and cognitive symptoms of depression.Jul 31, 2015

Pubmed Data : Complement Ther Med. 2015 Aug ;23(4):598-602. Epub 2015 Jun 18. PMID: 26275653
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Substances : Chlorella (Algae)
Diseases : Anxiety Disorders, Depression, Depressive Disorder
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
Additional Keywords : Natural Substances Versus Drugs, Significant Treatment Outcome
[+]

The consumption of probiotic yogurt or a multispecies probiotic capsule had beneficial effects on mental health parameters in petrochemical workers.Apr 15, 2015

Pubmed Data : Nutr Neurosci. 2015 Apr 16. Epub 2015 Apr 16. PMID: 25879690
Article Published Date : Apr 15, 2015
Study Type : Human Study
Additional Links
Substances : Probiotics
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Supplementation
[+]

The NAC group exhibited significantly greater reduction on hs-CRP levels than placebo group.Apr 30, 2018

Pubmed Data : Psychiatry Res. 2018 May ;263:268-274. Epub 2018 Mar 13. PMID: 29605103
Article Published Date : Apr 30, 2018
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : C-Reactive Protein, Depressive Disorder
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
[+]

The omega-3 fatty acid EPA is as effective as fluoxetine (Prozac) in treating major depressive disorder. Mar 01, 2008

Pubmed Data : Aust N Z J Psychiatry. 2008 Mar;42(3):192-8. PMID: 18247193
Article Published Date : Mar 01, 2008
Study Type : Human Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid)
Diseases : Depression, Depressive Disorder
Additional Keywords : Natural Substances Versus Drugs, Safety of Natural Substances
[+]

The prevalence of cognitive impairment and depressed mood decreased with increases in physiological melatonin levels in this study. Jun 07, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Endocrinol Metab. 2015 Jun 8:jc20151859. Epub 2015 Jun 8. PMID: 26052727
Article Published Date : Jun 07, 2015
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction, Depressive Disorder
Pharmacological Actions : Antidepressive Agents, Neuroprotective Agents
[+]

The results of our study support a majority of research showing the association in depressed patients between suicidal behavior and low levels of total and LDL cholesterol.Sep 30, 2014

Pubmed Data : Acta Neuropsychiatr. 2014 Oct ;26(5):315-20. Epub 2014 Jul 30. PMID: 25076263
Article Published Date : Sep 30, 2014
Study Type : Human Study
Additional Links
Diseases : Depression, Depressive Disorder, Low Cholesterol, Suicidal Behavior, Suicidal Ideation
Additional Keywords : Diseases that are Linked, Risk Factors
[+]

These findings demonstrate the additive effect of acupuncture to antidepressant treatment.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuroimage Clin. 2016 ;12:746-752. Epub 2016 Aug 27. PMID: 27812501
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Acupuncture
Problem Substances : Fluoxetine (trade name Prozac)
[+]

These findings demonstrated a relationship between vitamin intake and depressive symptoms.Dec 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Dec 3 ;9(12). Epub 2017 Dec 3. PMID: 29207502
Article Published Date : Dec 02, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Depressive Disorder, Vitamin B Deficiency, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

These findings suggest that both vitamin D and total cholesterol are important targets for the prevention and treatment of depression.Jul 03, 2016

Pubmed Data : Public Health Nutr. 2016 Jul 4:1-8. Epub 2016 Jul 4. PMID: 27373847
Article Published Date : Jul 03, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Depressive Disorder, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

These preliminary data support the utility of online yoga tailored specifically for people with mood disorders.Dec 31, 2017

Pubmed Data : J Psychiatr Pract. 2018 Jan ;24(1):60-67. PMID: 29320386
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Yoga
Pharmacological Actions : Antidepressive Agents
[+]

These results suggest a pro-inflammatory diet is associated with adverse mental health.Sep 30, 2018

Pubmed Data : Clin Nutr. 2018 Oct ;37(5):1485-1491. Epub 2017 Sep 5. PMID: 28912008
Article Published Date : Sep 30, 2018
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Western Diet
[+]

These results support the hypothesis that higher serum 25(OH)D concentrations protect against depression.Apr 30, 2015

Pubmed Data : Br J Nutr. 2015 May ;113(9):1418-26. PMID: 25989997
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : 25-hydroxyvitamin D, Risk Reduction
[+]

This study contributes to previous reports on the involvement of gut microbiota in psychiatric disorders by demonstrating that microbial populations are associated with depression.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Behav Immun. 2015 Aug ;48:186-94. Epub 2015 Apr 13. PMID: 25882912
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Diseases : Depression, Depressive Disorder, Inflammation
Additional Keywords : Microbiota
[+]

Training in mindfulness helps patients with a history of suicidal depression weaken the association between depressive symptoms and suicidal thinking. Aug 23, 2015

Pubmed Data : J Consult Clin Psychol. 2015 Aug 24. Epub 2015 Aug 24. PMID: 26302249
Article Published Date : Aug 23, 2015
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder, Suicidal Ideation
Therapeutic Actions : Mindfullness Training
Additional Keywords : Significant Treatment Outcome
[+]

Transcranial photobiomodulation for the treatment of major depressive disorder.Oct 19, 2018

Pubmed Data : Photomed Laser Surg. 2018 Oct 20. Epub 2018 Oct 20. PMID: 30346890
Article Published Date : Oct 19, 2018
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Infrared Light, Laser Treatment: Low-Level
Pharmacological Actions : Antidepressive Agents
[+]

Typhoid but not placebo injection produced an inflammatory response indexed by increased circulating interleukin-6 and significant mood reduction at 3 hours. Aug 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Psychiatry. 2009 Sep 1 ;66(5):407-14. Epub 2009 May 7. PMID: 19423079
Article Published Date : Aug 31, 2009
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder, Inflammation, Mood Disorders
Additional Keywords : Cytokines
Anti Therapeutic Actions : Vaccination: All
[+]

Tyrosine improves clinical signs of dopamine-dependent depression.Jan 01, 1988

Pubmed Data : C R Acad Sci III. 1988;306(3):93-8. PMID: 3126995
Article Published Date : Jan 01, 1988
Study Type : Human Study
Additional Links
Substances : Tyrosine
Diseases : Depressive Disorder
[+]

Vitamin D supplementation improves female sexual functioning and mood in women with low vitamin D status.Feb 13, 2018

Pubmed Data : Endokrynol Pol. 2018 Feb 14. Epub 2018 Feb 14. PMID: 29442353
Article Published Date : Feb 13, 2018
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Depressive Disorder, Sexual Behavior, Vitamin D Deficiency
[+]

Yoga plus coherent breathing led to depressive symptoms declining significantly in patients with major depressive disorder.Feb 28, 2017

Pubmed Data : J Altern Complement Med. 2017 Mar ;23(3):201-207. Epub 2017 Feb 16. PMID: 28296480
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Therapeutic Breathing, Yoga
Pharmacological Actions : Antidepressive Agents
[+]

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

Pubmed Data : Metab Brain Dis. 2015 Jul 30. Epub 2015 Jul 30. PMID: 26220010
Article Published Date : Jul 29, 2015
Study Type : Animal Study
Additional Links
Substances : Ferulic acid, Piperine
Diseases : Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Increased Bioavailability, Natural Substance Synergy
[+]

A water extract of dandelion roots and leaves demonstrated antidepressant effects in an animal model.Jul 31, 2014

Pubmed Data : Pharm Biol. 2014 Aug ;52(8):1028-32. Epub 2014 Mar 10. PMID: 24611722
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Plant Extracts
[+]

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice.May 23, 2018

Pubmed Data : Acta Pharmacol Sin. 2018 May 24. Epub 2018 May 24. PMID: 29795356
Article Published Date : May 23, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Brain Inflammation , Depressive Disorder
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Pubmed Data : J Nutr Biochem. 2016 Oct 11 ;39:134-144. Epub 2016 Aug 11. PMID: 27833054
Article Published Date : Oct 10, 2016
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Depression, Depressive Disorder, Inflammation
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
[+]

Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD.Feb 16, 2018

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 17 ;84(Pt A):129-139. Epub 2018 Feb 17. PMID: 29458190
Article Published Date : Feb 16, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabinoids
Diseases : Depressive Disorder
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

Curcumin can normalize the depressive like behaviors of neuropathic mice.Apr 30, 2014

Pubmed Data : Psychopharmacology (Berl). 2014 May ;231(10):2171-87. Epub 2013 Dec 3. PMID: 24297305
Article Published Date : Apr 30, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Depression, Depressive Disorder, Neuropathic Pain
Pharmacological Actions : Analgesics, Antidepressive Agents
[+]

Curcumin may play a therapeutic role in treating depression. Dec 01, 2008

Pubmed Data : Psychopharmacology (Berl). 2008 Dec;201(3):435-42. Epub 2008 Sep 3. PMID: 18766332
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Depressive Disorder
[+]

DDW in mice counteracted the behavioral, transcriptional and proliferative changes typical of the depressive-like states, which was comparable to the effects of citalopram.Jan 14, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Behav Brain Res. 2015 Jan 15 ;277:237-44. Epub 2014 Aug 1. PMID: 25092571
Article Published Date : Jan 14, 2015
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Depression, Depressive Disorder, Stress
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Deuterium Content Of Water, Natural Substances Versus Drugs, Risk Factors, Superiority of Natural Substances versus Drugs
[+]

Electroacupuncture may act on depression by enhancing p-ERK1/2 and p-p38 in the hippocampus. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:650729. Epub 2015 Aug 20. PMID: 26366182
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Diseases : Depressive Disorder, Stress
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antidepressive Agents
[+]

This study found that chronic mild stress induced depressive like behavior in rats and was associated with decreased cholesterol levels.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2015 ;14:22. Epub 2015 Mar 24. PMID: 25889773
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Diseases : Depressive Disorder, Low Cholesterol, Stress
Additional Keywords : Risk Factors
[+]

Urtica dioica reversed dexamethasone induced hyperglycemia and its associated complications such as depressive like behavior and cognitive dysfunction.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metab Brain Dis. 2014 Mar ;29(1):121-30. Epub 2014 Jan 17. PMID: 24435938
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Depressive Disorder, Diabetes Mellitus: Type 2, Memory Disorders: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antidepressive Agents, Hypoglycemic Agents
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Dexamethasone
[+]

A review of the preventive and therapeutic potential of vitamin C in mental disorders.Jan 31, 2018

Pubmed Data : Curr Med Sci. 2018 Feb ;38(1):1-10. Epub 2018 Mar 15. PMID: 30074145
Article Published Date : Jan 31, 2018
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Alzheimer's Disease, Depressive Disorder, Schizophrenia
Pharmacological Actions : Neuroprotective Agents
[+]

Adjunctive treatment with huperzine A was associated with a faster resolution of the cognitive symptoms that frequently accompany major depressive disorder.Apr 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Shanghai Arch Psychiatry. 2016 Apr 25 ;28(2):64-71. PMID: 27605862
Article Published Date : Apr 24, 2016
Study Type : Review
Additional Links
Substances : Huperzine
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Acetylcholinesterase Inhibitor
[+]

Findings from initial clinical trials suggest that saffron may improve the symptoms and the effects of depression, premenstrual syndrome, sexual dysfunction and infertility, and excessive snacking behaviors.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Integr Med. 2015 Jul ;13(4):231-40. PMID: 26165367
Article Published Date : Jun 30, 2015
Study Type : Review
Additional Links
Substances : Saffron
Diseases : Depression, Depressive Disorder, Infertility
Additional Keywords : Significant Treatment Outcome
[+]

Folate may have a therapeutic role in treating depressive symtoms. Jan 01, 2009

Pubmed Data : J Clin Psychiatry. 2009;70 Suppl 5:12-7. PMID: 19909688
Article Published Date : Jan 01, 2009
Study Type : Review
Additional Links
Substances : Folic Acid
Diseases : Depression, Depressive Disorder
[+]

Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between major depressive disorder and its medical comorbidities.Dec 31, 2016

Pubmed Data : Psychother Psychosom. 2017 ;86(1):31-46. Epub 2016 Nov 25. PMID: 27884012
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Diseases : Depressive Disorder, Dysbiosis
Additional Keywords : Microbiota
[+]

Probiotic supplementation can positively affect anxiety and depressive symptoms.Aug 31, 2016

Pubmed Data : Nutr Res. 2016 Sep ;36(9):889-98. Epub 2016 Jun 21. PMID: 27632908
Article Published Date : Aug 31, 2016
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Anxiety, Depressive Disorder
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Probiotics could serve as an adjuvant therapy in major depressive disorder.May 25, 2016

Pubmed Data : Curr Neuropharmacol. 2016 May 26. Epub 2016 May 26. PMID: 27226112
Article Published Date : May 25, 2016
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Depressive Disorder
Pharmacological Actions : Antidepressive Agents
[+]

Psilocybin and MDMA for the treatment of trauma-related psychopathology.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Rev Psychiatry. 2021 May ;33(3):229-249. Epub 2021 Jun 14. PMID: 34121583
Article Published Date : Apr 30, 2021
Study Type : Review
Additional Links
Substances : Psilocybin
Diseases : Depressive Disorder, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Antidepressive Agents
[+]

Psychiatric comorbidity in inflammatory bowel disease may affect course of intestinal disease.Dec 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychiatr Pol. 2016 Dec 23 ;50(6):1157-1166. PMID: 28211554
Article Published Date : Dec 22, 2016
Study Type : Review
Additional Links
Diseases : Depressive Disorder, Inflammatory Bowel Diseases
Additional Keywords : Gut-brain Axis
[+]

Salvinorin A could therapeutic use in the treatment of major depressive disorders.Dec 31, 2015

Pubmed Data : Curr Neuropharmacol. 2016 ;14(2):165-76. PMID: 26903446
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Salvia divinorum
Diseases : Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
[+]

The bioactive components of Crocus sativus have been found to modulate several synaptic processes via direct/indirect interplay with neurotransmitter receptor functions.Dec 31, 2014

Pubmed Data : CNS Neurol Disord Drug Targets. 2015 ;14(7):880-902. PMID: 25714974
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Saffron
Diseases : Alzheimer's Disease, Depressive Disorder
Pharmacological Actions : Neuroprotective Agents
[+]

The evidence overall strongly suggests that psychedelics should be re-examined in modern clinical trials for their use in unipolar mood disorders.Nov 30, 2016

Pubmed Data : J Psychopharmacol. 2016 Dec ;30(12):1220-1229. Epub 2016 Nov 17. PMID: 27856684
Article Published Date : Nov 30, 2016
Study Type : Review
Additional Links
Substances : Psychedelics:All
Diseases : Depressive Disorder, Mood Disorders
Pharmacological Actions : Antidepressive Agents
[+]

The ingestion of gluten seems to be related to disease.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Hosp. 2014 ;30(6):1203-10. Epub 2014 Dec 1. PMID: 25433099
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorders, Depressive Disorder, Dermatitis, Fibromyalgia, Headache, Irritable Bowel Syndrome, Multiple Sclerosis, Schizophrenia
Additional Keywords : Risk Factors
Problem Substances : Gluten
[+]

The present review is to provide an integrated account of how life stress affects inflammation and how stress–inflammation pathways may in turn be linked with depression.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychol Bull. 2014 May ;140(3):774-815. Epub 2014 Jan 13. PMID: 24417575
Article Published Date : Apr 30, 2014
Study Type : Review
Additional Links
Diseases : Depression, Depressive Disorder, Inflammation, Stress
Additional Keywords : Cytokines, Diseases that are Linked, Social Stressors
[+]

This review highlights current evidence supporting the disease-altering potential of PA and exercise through modifications of neuroimmune responses.Mar 25, 2016

Pubmed Data : Brain Res Bull. 2016 Mar 26 ;125:19-29. Epub 2016 Mar 26. PMID: 27021169
Article Published Date : Mar 25, 2016
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Brain Inflammation , Depressive Disorder, Parkinson's Disease, Schizophrenia
Therapeutic Actions : Exercise
Additional Keywords : Physical Activity
[+]

This review will highlight the role of inflammation in the pathophysiology of psychiatric disorders, such as MDD, BD, schizophrenia, and autism.May 13, 2015

Pubmed Data : Neuroscience. 2015 May 14 ;300:141-154. Epub 2015 May 14. PMID: 25981208
Article Published Date : May 13, 2015
Study Type : Review
Additional Links
Diseases : Autism, Bipolar Disorder, Depressive Disorder, Inflammation, Psychiatric Disorders, Schizophrenia
Additional Keywords : Diseases that are Linked
[+]

This study provides insights into the role of the microbiota-gut-brain-axis in depressive disorders.Oct 26, 2016

Pubmed Data : Nervenarzt. 2016 Oct 27. Epub 2016 Aug 27. PMID: 27787576
Article Published Date : Oct 26, 2016
Study Type : Commentary
Additional Links
Diseases : Depressive Disorder
Additional Keywords : Gut-brain Axis, Microbiome
[+]

Yoga and exercise positively affect depression and anxietyApr 15, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am Fam Physician. 2010 Apr 15 ;81(8):981-6. PMID: 20387774
Article Published Date : Apr 15, 2010
Study Type : Review
Additional Links
Diseases : Depressive Disorder
Therapeutic Actions : Exercise, Yoga
[+]

Crocus sativus L. (saffron) was shown to be as effective as fluoxetine in the treatment of depression.Mar 30, 2007

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):439-42. Epub 2006 Dec 15. PMID: 17174460
Article Published Date : Mar 30, 2007
Additional Links
Diseases : Depressive Disorder
[+]

Leaky Gut Syndrome may play a crucial role in major depression. - Article 1Feb 01, 2008

Pubmed Data : Neuro Endocrinol Lett. 2008 Feb;29(1):117-24. PMID: 18283240
Article Published Date : Feb 01, 2008
Additional Links
Diseases : Depressive Disorder
[+]

Piperine possesses anti-depression like activity and cognitve enhancing effects in the rat experimental model. - Article 1Nov 01, 2005

Pubmed Data : Pancreas. 2005 Nov;31(4):317-24. PMID: 18639606
Article Published Date : Nov 01, 2005
Additional Links
Diseases : Depressive Disorder
[+]

Sam-e significantly improves major depression.May 01, 1990

Pubmed Data : Acta Psychiatr Scand. 1990 May;81(5):432-6 PMID: 2113347
Article Published Date : May 01, 1990
Additional Links
Diseases : Depressive Disorder
[+]

St. Johns wort appears to be safe and effective in patients with moderate depressive disorders.Jul 01, 2004

Pubmed Data : Adv Ther. 2004 Jul-Aug;21(4):265-75. PMID: 15605620
Article Published Date : Jul 01, 2004
Additional Links
Diseases : Depressive Disorder

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