Diabetes: Cardiovascular Illness

Name	AC	CK
Omega-3 Fatty Acids	4	42
Carnitine	4	40
Curcumin	12	30
Fish	1	20
Flavonoids	2	20
Hibiscus	2	20
Magnesium	2	20
Sesame Seed Oil	2	20
Soy Protein	2	20
Resveratrol	10	18
Alpha-Lipoic Acid	4	15
Cinnamon	2	12
Pycnogenol (Pine Bark)	2	12
Arginine	1	10
B-complex	1	10
Bay leaf	1	10
Chia	1	10
Cocoa	1	10
Cranberry	1	10
Dates	1	10
Eicosapentaenoic acid (EPA)	1	10
Flaxseed	1	10
Oyster Mushroom	1	10
Polyphenols	1	10
Red Yeast Rice	1	10
Roselle	1	10
Sesame Seeds	1	10
Turmeric	1	10
Astaxanthin	2	4
Ginger	2	4
Ginsenosides	2	4
Grape Seed Extract	2	4
Mangiferin	2	4
Peanut	2	4
Vitamin E	2	4
Acetyl-l-carnitine	1	2
Asiatic Acid	1	2
Bee Propolis	1	2
Caffeic acid phenethyl ester	1	2
Cannabidiol	1	2
Caraway	1	2
Carnosine	1	2
Cinnamaldehyde	1	2
EGCG (Epigallocatechin gallate)	1	2
Embelia ribes	1	2
Fish Oil	1	2
Gamma-Linoleic Acid (GLA)	1	2
Genistein	1	2
Hibiscus sabdariffa	1	2
Histidine	1	2
Luteolin	1	2
Persimmon	1	2
Pine Bark Extract	1	2
Pomegranate	1	2
Royal Jelly	1	2
Sesamin	1	2
Stilbenes	1	2
Bamboo	1	1
Coriolus versicolor	1	1

Name	AC	CK
Glipizide	2	40
Sulfonylureas	3	40
Aspirin	2	30
Glibenclamide	2	30
Rosiglitazone (trade name Avandia)	2	30
Glyburide	1	20
Statin Drugs	2	20
Fructose	1	10
Insulin	1	10
Metformin	1	10
Simvastatin	1	10

Name	AC	CK
Dietary Modification: Low Carbohydrate	1	10
Dietary Modification: Mediterranean Diet	1	10
Dietary Modification: Paleolithic/Stone Age Diet	1	10
Exercise	1	10
Fasting/Caloric Restriction	1	10
Laughter/Humor	1	10
Yoga	1	10

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Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

Click here to read the entire abstract

Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Cardiovascular Diseases, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Problem Substances : Aspirin

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Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.Apr 15, 2003

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Pubmed Data : Circulation. 2003 Apr 15;107(14):1852-7. Epub 2003 Mar 31. PMID: 12668520

Article Published Date : Apr 15, 2003

Study Type : Meta Analysis

Additional Links

Substances : Fish, Omega-3 Fatty Acids

Diseases : Coronary Artery Disease, Diabetes: Cardiovascular Illness, Mortality: All-Cause

Pharmacological Actions : Cardioprotective

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Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.Dec 01, 2008

Click here to read the entire abstract

Pubmed Data : Diabetes Res Clin Pract. 2008 Dec;82(3):391-5. Epub 2008 Oct 21. PMID: 18945509

Article Published Date : Dec 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Glibenclamide, Glipizide

Adverse Pharmacological Actions : Cardiotoxic

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Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes.Jun 14, 2007

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Pubmed Data : Exp Clin Endocrinol Diabetes. 2006 Mar;114(3):127-34. PMID: 16636979

Article Published Date : Mar 01, 2006

Study Type : Human Study

Additional Links

Diseases : Arteriosclerosis, C-Reactive Protein, Cardiovascular Diseases, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2, Metabolic Syndrome X

Additional Keywords : Diseases that are Linked

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C-reactive protein more than LDL determines cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus.Nov 01, 2009

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Pubmed Data : Am J Kidney Dis. 2009 Nov;54(5):902-11. Epub 2009 Sep 25. PMID: 19781835

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Pubmed Data : J Agric Food Chem. 2009 Sep 9;57(17):8010-7. PMID: 19681613

Click here to read the entire abstract

Pubmed Data : J Hum Hypertens. 2008 Aug 7. [Epub ahead of print] PMID: 18685605

Article Published Date : Aug 07, 2008

Study Type : Human Study

Additional Links

Substances : Hibiscus

Diseases : Diabetes: Cardiovascular Illness, Hypertension

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High dose magnesium may improve control and/or prevent complications in type 2 diabetic patients. May 01, 1998

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Pubmed Data : Diabetes Care. 1998 May;21(5):682-6. PMID: 9589224

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Pubmed Data : Atherosclerosis. 2006 Oct;188(2):455-61. Epub 2005 Dec 27. PMID: 16384561

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Paradoxically, elevated HbA1c levels were associated with improved survival in patients with diabetes and advanced heart failure.Jan 01, 2006

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Pubmed Data : Am Heart J. 2006 Jan;151(1):91. PMID: 16368297

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Diabetes: Cardiovascular Illness, Diabetes: Glycation/A1C

Additional Keywords : Paradoxical Results

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Pycnogenol improves diabetes control, lowers cardiovascular disease risk factors, and reduces the need for hypertension medication in type diabetic patients. May 01, 2008

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Pubmed Data : Nutr Res. 2008 May;28(5):315-20. PMID: 19083426

Article Published Date : May 01, 2008

Pubmed Data : Transl Res. 2010 Jan;155(1):6-9. PMID: 20004356

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

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Type 2 diabetic patients patients treated with statin drugs have decreased coq10 levels and may be associated with subclinical diabetic cardiomyopathy reversible by CoQ10 supplementation.Apr 01, 1999

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Pubmed Data : Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID: 10337451

Article Published Date : Apr 01, 1999

Study Type : Human Study

Additional Links

Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies

Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion

Problem Substances : Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic

[+]

Click here to read the entire abstract

Pubmed Data : Vascul Pharmacol. 2008 Jul;49(1):1-5. Epub 2008 Mar 27. PMID: 18468493

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Pubmed Data : Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82. Epub 2009 May 19. PMID: 19473193

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Aortic Stenosis, Diabetes: Cardiovascular Illness, Endothelial Dysfunction, Hyperglycemia

Pharmacological Actions : Cardioprotective

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Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.Sep 01, 1986

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Pubmed Data : JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458

Article Published Date : Sep 01, 1986

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Pharmacological Actions : Hypolipidemic

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Click here to read the entire abstract

Pubmed Data : BMC Complement Altern Med. 2010;10:57. Epub 2010 Oct 14. PMID: 20946622

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Diabetes: Cardiovascular Illness, Endothelial Dysfunction

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

[+]

Embelia ribes has a protective effect on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats.Jan 01, 2008

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Pubmed Data : Biofactors. 2008;33(1):49-60. PMID: 18508204

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Pubmed Data : Br J Nutr. 2006 Oct;96(4):660-6. PMID: 17010224

Mangiferin suppresses blood lipids in type 2 diabetes. Oct 01, 2000

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Pubmed Data : Scand J Immunol. 2000 Oct;52(4):348-55. PMID: 11558577

Article Published Date : Oct 01, 2000

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2, Hyperlipidemia, Triglycerides: Elevated

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Xanthones

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Myricitrin alleviates oxidative stress-induced inflammation and apoptosis and protects against diabetic cardiomyopathy.Jan 12, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 03 13 ;7:44239. Epub 2017 Mar 13. PMID: 28287141

Article Published Date : Jan 12, 2017

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Diabetes: Cardiovascular Illness, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

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Resveratrol ameliorates vasculopathy in diabetic rats.Mar 01, 2010

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Pubmed Data : Diabetes Metab Res Rev. 2010 Mar;26(3):212-22. PMID: 20474069

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Pubmed Data : Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20. Epub 2009 May 8. PMID: 19429820

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Pubmed Data : Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H833-43. Epub 2009 Dec 11. PMID: 20008278

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol, Stilbenes

Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness

Pharmacological Actions : Antioxidants, Sarcoplasmic Calcium ATPase Up-regulation, SIRT1 Activator

[+]

Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy.Mar 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2023 Apr ;160:114382. Epub 2023 Feb 9. PMID: 36773525

Click here to read the entire abstract

Pubmed Data : Food Funct. 2023 Mar 20 ;14(6):2740-2749. Epub 2023 Mar 20. PMID: 36852907

Article Published Date : Mar 19, 2023

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Diabetes: Cardiovascular Illness

Pharmacological Actions : Autophagy Inhibitors, Cardioprotective

[+]

[Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats].Oct 31, 2007

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Yakugaku Zasshi. 2007 Nov ;127(11):1877-82. PMID: 17978564

Click here to read the entire abstract

Pubmed Data : Int J Mol Med. 2010 May;25(5):729-34. PMID: 20372816

Article Published Date : May 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Advanced Glycation End products (AGE), Atherosclerosis, Diabetes: Cardiovascular Illness

Pharmacological Actions : Antioxidants, Cardioprotective

Additional Keywords : Stilbenes

[+]

Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy.Jun 30, 2021

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Pubmed Data : Int Immunopharmacol. 2021 Jul ;96:107728. Epub 2021 May 7. PMID: 33971494

Article Published Date : Jun 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor

Additional Keywords : Natural Substance Synergy

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View the Evidence: 126 Abstracts with Diabetes: Cardiovascular Illness Research

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There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.Jun 01, 2010

Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.Apr 15, 2003

Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.Dec 01, 2008

Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes.Jun 14, 2007

Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.Jun 01, 2009

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

The consumption of omega-3 fatty acid supplements decreases homocysteine levels in diabetic patients.Jun 01, 2010

"Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus."Jun 01, 2011

A flaxseed-derived lignan supplement may reduce C-reactive protein in type 2 diabetics. Apr 01, 2009

A low carbohydrate diet has the potential to reduce abdominal fat and adverse lipid changes in patients with type 2 diabetes.Jan 01, 2011

A tea made from Roselle (Hibiscus sabdariffa) improves blood lipid profiles in patients with diabetes. Aug 01, 2009

Aspirin increases mortality in diabetic patients without cardiovascular disease. Dec 01, 2009

Bay leaves improve glucose and lipid profile of people with type 2 diabetes.Jan 01, 2009

C-reactive protein is a strong independent predictor of death in type 2 diabetes: association with multiple facets of the metabolic syndrome.Mar 01, 2006

C-reactive protein more than LDL determines cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus.Nov 01, 2009

Chia seed (S. hispanica) supplementation attenuates cardiovascular risk factors while maintaining good glycemic and lipid control in people with well-controlled type 2 diabetes. Nov 01, 2007

Cocoa flavanols reverse vascular dysfunction in diabetics.Jun 01, 2009

Cranberry extract has a favorble effect on blood lipid profiles in patients with type 2 diabetes. Dec 01, 2008

Date consumption (and mainly the Hallawi variety) by healthy subjects, despite their high sugar content, demonstrates beneficial effects on serum triacylglycerol and oxidative stress and does not worsen serum glucose and lipid/lipoprotein pattern. Sep 09, 2009

Eicosapentaenoic acid (EPA) reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Mar 01, 2007

Glibenclamide in combination with metformin is associated with significantly higher mortality. Nov 01, 2006

Hibiscus infusion had positive effects on Blood Pressure in type 2 diabetics.Aug 07, 2008

High dose magnesium may improve control and/or prevent complications in type 2 diabetic patients. May 01, 1998

High doses of fructose raise the BP and cause the features of metabolic syndrome. Mar 01, 2010

L-arginine protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.May 01, 2009

L-carnitine lowers lipoprotein (a) serum levels in patients with type 2 diabetes, whereas simvastatin increases them. Oct 01, 2006

L-carnitine significantly lowered the plasma Lp(a) level compared with placebo in selected hypercholesterolemic patients with newly diagnosed type 2 DM.May 01, 2003

L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes.Jan 01, 2009

Laughter therapy can be used as non-pharmacological treatment for the prevention of diabetic microvascular complications.Dec 01, 2005

More frequent statin use is associated with accelerated coronary artery calcification, and in a subpopulation aortic calcification, in T2DM patients with advanced atherosclerosis.Aug 07, 2012

Omega-3 fatty acids improve macro- and microvascular function in subjects with type 2 diabetes mellitus.Jan 13, 2010

Oral magnesium supplementation for 4-16 weeks may be effective in reducing plasma fasting glucose levels and raising HDL cholesterol in patients with Type 2 diabetes.Jan 01, 2008

Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects.Jan 01, 2007

Paradoxically, elevated HbA1c levels were associated with improved survival in patients with diabetes and advanced heart failure.Jan 01, 2006

Pycnogenol improves diabetes control, lowers cardiovascular disease risk factors, and reduces the need for hypertension medication in type diabetic patients. May 01, 2008

Red Yeast Rice significantly lowers all-cause mortality in type 2 diabetics with coronary heart disease.Aug 01, 2010

Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.Jan 31, 2014

Sesame seed paste reduces cardiovascular disease risk factors in type 2 diabetics. Oct 31, 2013

Soy inclusion in the diet can modify the risk factors of heart disease and improve kidney function in patients with type 2 diabetes with nephropathy.Oct 01, 2003

Soy protein consumption significantly affected cardiovascular risk factors and kidney-related biomarkers among type 2 diabetic patients with nephropathy.Nov 01, 1984

The coadministration of carnitine and simvastatin resulted in a significant reduction in Lp(a) and apo(a).Aug 01, 2009

The consumption of a traditional Greek Mediterranean diet even for a short period can reduce platelet activity in patients suffering from type 2 diabetes mellitus and in healthy subjects.Jan 01, 2006

The intake of 2g of cinnamon for 12 weeks significantly reduces the HbA1c, systolic and diastolic blood pressures among poorly controlled type 2 diabetes patients. Nov 01, 2004

The paleolithic diet has a beneficial affect on cardiovascular risk factors in type 2 diabetes.Jan 01, 2009

The substitution of sesame seed oil as the sole edible oil lowers blood pressure and glucose in hypertensive diabetics. Sep 01, 2006

The use of glyburide and/or metformin results in increased mortality in type 2 diabetics with coronary artery disease. Feb 01, 2001

The use of rosiglitazone (Avandia) in type 2 diabetic patients is associated with increased risk of heart failure. Jan 29, 2010

There are 9 easily measured risk factors (smoking, lipids, hypertension, diabetes, obesity, diet, physical activity, alcohol consumption, and psychosocial factors) that account for over 90% of the risk of acute myocardial infarction (AMI).Apr 16, 2006

There may be an association between increasing exogenous insulin dose and increased risk of all-cause mortality.Mar 31, 2015

Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine, a predictor of cardiovascular events, in patients with type 2 diabetes mellitus.Jan 01, 2010

Type 2 diabetic patients patients treated with statin drugs have decreased coq10 levels and may be associated with subclinical diabetic cardiomyopathy reversible by CoQ10 supplementation.Apr 01, 1999

Type 2 diabetic patients with ischemic heart disease using metformin, alone or in combination with sulfonylureas, exhibited a significantly increased mortality.Jan 01, 1999

Yoga has a positive role in modifying certain cardiovascular functions in type 2 diabetic patients.Jun 01, 2002

Acacetin attenuates diabetes-induced cardiomyopathy.May 04, 2022

Apocynin attenuates diabetic cardiomyopathy by suppressing ASK1-p38/JNK signaling.Oct 14, 2021

"Pycnogenol improves left ventricular function in streptozotocin-induced diabetic cardiomyopathy in rats."Jun 30, 2010

6-gingerol alleviates ferroptosis and inflammation of diabetic cardiomyopathy.Dec 31, 2021

A combination of Omega-3 fatty acids and vitamin E ameliorates or prevents vascular reactivity alterations in diabetes. Dec 01, 2009

Alpha lipoic may have potential clinical applications for the treatment or prevention of hypertriglyceridemia and diabetic dyslipidemia.May 01, 2009

Antioxidant and gamma linolenic acid have a protective effect against nerve and vascular dysfunction in experimental diabetes. Sep 01, 1999

Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice.Aug 31, 2015

Astaxanthin ameliorates endothelial dysfunction in diabetic rats.Jan 01, 2011

Astaxanthin may attenuate diabetes associated coagulatory, oxidative, and inflammatory stress.Feb 06, 2012

Caffeic acid phenetyl ester, a compound found within bee propolis, protects the diabetic heart against oxidative stress. Feb 01, 2005

Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.Dec 14, 2010

Caraway reduces cholesterol and triglycerides in normal and diabetic rats. Jul 19, 2006

Chronic treatment of diabetic rats with EGCG could prevent the abnormal functional changes in vascular reactivity in diabetic rats.Dec 01, 1975

Chronic treatment of diabetic rats with genistein could prevent the abnormal functional changes in vascular reactivity in diabetic rats. Jul 01, 2008

Chronic treatment with resveratrol may prevent diabetes-related changes in the vascular system. Dec 09, 2009

Cinnamaldehyde protects from the hypertension associated with type 1 and type 2 diabetes.Aug 05, 2011

Curcumin ameliorates high glucose-induced adverse changes to the aortic endothelium of rats. Dec 01, 2009

Diabetes: Cardiovascular Illness

View the Evidence:
126 Abstracts with Diabetes: Cardiovascular Illness Research