Diabetes: Cognitive Dysfunction

Name	AC	CK
Curcumin	6	11
Cocoa	1	10
Leucine	1	10
Berberine	4	7
Gastrodin	3	6
Coenzyme Q10	2	4
Fenugreek	2	4
Fish Oil	2	4
Ginsenosides	2	4
Grape Seed Extract	2	4
Paeoniflorin	2	4
Piperine	2	4
Sesamin	2	4
Sesamol	2	4
Strawberry	2	4
Astaxanthin	2	3
Pomegranate	2	3
Bael	1	2
Betulinic acid	1	2
Bilberry	1	2
Chamomile	1	2
Ellagic Acid	1	2
Flavonoids	1	2
Formononetin	1	2
Frankincense	1	2
Gallic Acid	1	2
Ginger	1	2
Green Coffee Bean	1	2
Hawthorn	1	2
Hibiscus sabdariffa	1	2
Huperzine	1	2
Lotus	1	2
Luteolin	1	2
Mango leaf	1	2
Melatonin	1	2
Moringa oleifera	1	2
Nettle	1	2
Omega-3 Fatty Acids	1	2
Orthosiphon	1	2
P-Coumaric Acid	1	2
Parthenolide	1	2
Persimmon	1	2
Pistachio nut	1	2
Polyphenols	1	2
Safranal	1	2
Sulforaphane	1	2
Tanshinone IIA	1	2
Taurine	1	2
Tetrahydrocurcumin	1	2
Thymoquinone	1	2
Cannabinoids	1	1
Ferulic acid	1	1
Fucoidan	1	1

Name	AC	CK	Focus
Sucrose	1	2

Name	AC	CK
Yoga	2	11
Exercise: Resistance Training	1	10
Therapeutic Breathing	1	10
Exercise	2	3
Exercise: Aerobic	1	2
Exercise: Endurance	1	2

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Cocoa flavanols intake benefits cognitive function in type 1 diabetes.Jun 24, 2019

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Pubmed Data : Psychopharmacology (Berl). 2019 Jun 25. Epub 2019 Jun 25. PMID: 31236643

Article Published Date : Jun 24, 2019

Study Type : Human Study

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Substances : Cocoa

Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 1

Pharmacological Actions : Neuroprotective Agents

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Effects of resistance training using elastic bands on muscle strength with or without a leucine supplement in elderly patients with type 2 diabetes.Oct 16, 2020

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Pubmed Data : Endocr J. 2020 Oct 17. Epub 2020 Oct 17. PMID: 33071273

Article Published Date : Oct 16, 2020

Study Type : Human Study

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Substances : Leucine

Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2

Therapeutic Actions : Exercise: Resistance Training

Pharmacological Actions : Neuroprotective Agents

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Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes.Jul 08, 2022

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Pubmed Data : Diabetes Res Clin Pract. 2022 Jul 9 ;190:109989. Epub 2022 Jul 9. PMID: 35820563

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Pubmed Data : iScience. 2024 Apr 19 ;27(4):109511. Epub 2024 Mar 15. PMID: 38571759

Article Published Date : Apr 18, 2024

Pubmed Data : J Food Biochem. 2021 Jan ;45(1):e13581. Epub 2020 Dec 16. PMID: 33326146

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Persimmon

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Neuroprotective Agents

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Ameliorative effects of endurance training and Matricaria chamomilla flowers hydroethanolic extract on cognitive deficit in type 2 diabetes.Feb 28, 2021

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Pubmed Data : Biomed Pharmacother. 2021 Mar ;135:111230. Epub 2021 Feb 1. PMID: 33434853

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Pubmed Data : Saudi J Biol Sci. 2022 Apr ;29(4):2738-2748. Epub 2022 Jan 3. PMID: 35531250

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr 25. Epub 2023 Apr 25. PMID: 37097336

Article Published Date : Apr 24, 2023

Study Type : Animal Study

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Substances : Astragaloside

Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats.Aug 31, 2016

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Pubmed Data : Pharm Biol. 2016 Sep ;54(9):1528-38. Epub 2016 Jan 25. PMID: 26810454

Diseases : Diabetes: Cognitive Dysfunction, Diabetic Complications

Pharmacological Actions : Neuroprotective Agents

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Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters.Nov 30, 2019

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Pubmed Data : IBRO Rep. 2019 Dec ;7:90-96. Epub 2019 Oct 22. PMID: 31720488

Article Published Date : Nov 30, 2019

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Neuroprotective Agents

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Effect of tanshinone IIA on gut microbiome in diabetes-induced cognitive impairment.Dec 31, 2021

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Pubmed Data : Brain Pathol. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27537110

Article Published Date : Aug 17, 2016

Study Type : Animal Study

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Substances : Mango leaf

Diseases : Alzheimer's Disease, Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2, Vascular Dementia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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Pubmed Data : Appl Bionics Biomech. 2022 ;2022:5892463. Epub 2022 Apr 28. PMID: 35528541

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Oleuropein

Diseases : Brain Inflammation , Diabetes: Cognitive Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

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Orthosiphon stamineus standardized extract reverses streptozotocin-induced Alzheimer's disease-like condition.Apr 29, 2020

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Pubmed Data : Behav Brain Res. 2018 Jan 30 ;337:131-138. Epub 2017 Sep 20. PMID: 28939403

Article Published Date : Jan 29, 2018

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Diabetes: Cognitive Dysfunction, Diabetic Complications

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Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats. Nov 01, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Nov 2 ;109:281-292. Epub 2018 Nov 2. PMID: 30396086

Article Published Date : Nov 01, 2018

Study Type : Animal Study

Additional Links

Substances : Frankincense

Diseases : Alzheimer's Disease, Diabetes: Cognitive Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

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Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction.Jul 03, 2022

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Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats.Jun 01, 2007

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Pubmed Data : J Med Food. 2007 Jun;10(2):323-9. PMID: 17651069

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin

Diseases : Diabetes: Cognitive Dysfunction, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Click here to read the entire abstract

Pubmed Data : Basic Clin Pharmacol Toxicol. 2018 Jun 11. Epub 2018 Jun 11. PMID: 29890032

Article Published Date : Jun 10, 2018

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Alzheimer's Disease, Diabetes: Cognitive Dysfunction

Pharmacological Actions : Neuroprotective Agents

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These findings suggested that ALA may ameliorate cognition impairment via alleviating cerebral IR improvement and cerebral synaptic plasticity in diabetes.Dec 31, 2020

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Astaxanthin might inhibit oxidative stress and inflammatory responses by activating the Nrf2-ARE signalling pathway.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2018 ;9:748. Epub 2018 Jul 10. PMID: 30042685

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation

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Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids.Jan 03, 2019

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Pubmed Data : Pharmacol Res. 2019 Jan 4. Epub 2019 Jan 4. PMID: 30616019

Diabetes: Cognitive Dysfunction is a Sub of the following Topic

View the Evidence: 138 Abstracts with Diabetes: Cognitive Dysfunction Research

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Neuroprotective effect and possible mechanisms of berberine in diabetes-related cognitive impairment.Dec 31, 2021

Cocoa flavanols intake benefits cognitive function in type 1 diabetes.Jun 24, 2019

Effects of resistance training using elastic bands on muscle strength with or without a leucine supplement in elderly patients with type 2 diabetes.Oct 16, 2020

Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes.Jul 08, 2022

Pranayama (therapeutic breathing) and yoga postures have a therapeutic effect on cognitive brain functions in type 2 diabetes patients.May 01, 2010

Raw red beetroot consumption for 8 weeks in T2DM patients has beneficial impacts on cognitive function, glucose metabolism and other metabolic markers.May 31, 2021

Tai chi chuan was more effective than fitness walking in improving global cognitive function.Apr 02, 2023

This study suggests that a high intake of ultra-processed meat and oils/spreads may be associated with accelerated cognitive decline in older individuals with T2D.Jan 25, 2023

Yoga practice facilitates prefrontal oxygenation and working memory in type 2 diabetes mellitus patients.Feb 28, 2023

Genipin attenuates diabetic cognitive impairment.Dec 28, 2022

A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury.Apr 18, 2024

"Pomegranate (Punica granatum L.) flower improves learning and memory performances impaired by diabetes mellitus in rats."Dec 01, 2011

Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism.Dec 31, 2020

Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress.Feb 12, 2019

Albiflorin alleviates cognitive dysfunction in STZ-induced rats.Jan 27, 2021

Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum.Sep 30, 2022

Ameliorative effect of persimmon (Diospyros kaki) in cognitively impaired diabetic mice.Dec 31, 2020

Ameliorative effects of endurance training and Matricaria chamomilla flowers hydroethanolic extract on cognitive deficit in type 2 diabetes.Feb 28, 2021

An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia.Jan 08, 2024

Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain.Jun 16, 2021

Apocynin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.Dec 31, 2020

Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus.Mar 31, 2022

Astaxanthin may reduce type 2 diabetic associated cognitive declinein rats.Dec 31, 2015

Astragaloside IV supplementation attenuates cognitive impairment by inhibiting neuroinflammation and oxidative stress in type 2 diabetes.Dec 31, 2021

Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes-induced cognitive impairment.Apr 24, 2023

Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats.Aug 31, 2016

Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress.Jul 31, 2020

Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.Dec 31, 2018

Berberine possesses neuro-protective and antioxidative potentials and normalize neurochemical impairment distort by diabetes.Mar 15, 2021

Berberine significantly improved the cognitive function in diabetes.Jun 15, 2021

Bilberry fruit has beneficial effects on cognitive dysfunctions occurring in the brain during diabetes.Feb 28, 2017

Carnosine improves cognitive impairment through promoting SIRT6 expression and inhibiting ER stress in a diabetic encephalopathy model.Mar 17, 2022

Coenzyme Q10 supplementation reverses diabetes-related impairments in long-term potentiation induction in hippocampal dentate gyrus granular cells.Sep 23, 2019

Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes.Oct 31, 2022

CoQ10 supplementation can improve learning and memory deficits induced by diabetes in older subjects. Dec 20, 2018

Curcumin ameliorates memory deficits associated with diabetes in the rat. Mar 01, 2009

Curcumin attenuates diabetic encephalopathy in rats.Dec 08, 2007

Curcumin holds promise as an agent to prevent or treat central nervous system complications in diabetes.Jan 01, 2010

Curcumin prevents and/or delays diabetic complications associated with brain.Nov 12, 2008

Curcuminoids positively modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.Nov 01, 2008

Early intervention of gastrodin improved motor learning in diabetes.Jul 31, 2020

Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally‑induced diabetes mellitus.Mar 31, 2019

Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters.Nov 30, 2019

Effect of tanshinone IIA on gut microbiome in diabetes-induced cognitive impairment.Dec 31, 2021

Effects of endurance exercise and Urtica dioica on the functional, histological and molecular aspects of the hippocampus in STZ-induced diabetes. Jun 27, 2020

Electroacupuncture can improve the learning-memory ability in rats with diabetic cognitive impairment.Jun 24, 2022

Electroacupuncture improves cognitive impairment in diabetic cognitive dysfunction.Nov 21, 2022

Ellagic acid prevents streptozotocin-induced hippocampal damage and memory loss.Jul 31, 2021

Ellagic acid protects against diabetes-associated behavioral deficits in rats.Mar 30, 2019

Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats.Jul 19, 2019

Fish oil supplementation attenuates cognitive impairment by inhibiting neuroinflammation in STZ-induced diabetes.Aug 03, 2020

Fish oil supplementation in diabetics may prevent memory degeneration.Apr 16, 2012

Fragaria nilgerrensis extract had positive effects on STZ-induced memory dysfunction.Dec 31, 2017

Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration.Dec 31, 2016

Gastrodin alleviates cognitive dysfunction and depressive-like behaviours.Dec 09, 2018

Gastrodin ameliorates motor learning deficits through preserving cerebellar long-term depression pathways in diabetic rats.Dec 31, 2018

Ginger has a neuroprotective effect in diabetic rats.Dec 22, 2010

Ginsenoside ameliorated diabetic cognitive decline.Jun 09, 2018

Ginsenoside Rg1 treatment protects against cognitive dysfunction.Apr 30, 2023

Grape seed proanthocyanidin extract and insulin prevents cognitive decline in type 1 diabetic rats.Oct 02, 2018

Grape seed proanthocyanidin extract may be an effective agent for the treatment of cognitive deficits associated with sporadic Alzheimer's disease.May 31, 2020

Harmine ameliorates cognitive impairment by inhibiting NLRP3 inflammasome activation.Dec 31, 2019

Hesperidin-conjugated bimetallic nanoparticles improved learning and memory in the STZ rat model.Aug 09, 2023

Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice.Feb 28, 2018

High-intensity interval training reduced oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes.Dec 31, 2022

Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats.May 04, 2014

Hydro-alcoholic extract from the T. foenum-graceum seed prevented memory deficits resulting from diabetes.Jun 05, 2019

Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice.Feb 11, 2022

It is recommended that safranal be considered for diabetes management.Aug 05, 2018

Luteolin could ameliorate the cognitive dysfunctions in streptozotocin-induced diabetic rat model.Aug 06, 2018

Mango leaf extract treatment may provide a useful tool to target different aspects of Alzheimer's disease and vascular dementia pathology.Aug 17, 2016

Melatonin might be a therapeutic option for helping patients suffering from diabetes and contributed to Alzheimer's disease.Dec 31, 2019

Diabetes: Cognitive Dysfunction

View the Evidence:
138 Abstracts with Diabetes: Cognitive Dysfunction Research