Diabetic Neuropathies

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38 Substances Researched for Diabetic Neuropathies
NameACCKFocus
Alpha-Lipoic Acid525Locked
Palmitoylethanolamide 121Locked
Vitamin D220Locked
Ascorbyl Palmitate110Locked
Benfotiamine110Locked
Biotin110Locked
Cannabis110Locked
Carnitine, Acetyl-L-110Locked
Delta-tetrahydrocannabinol (THC)110Locked
Homeopathic Medicine: All110Locked
Quercetin110Locked
Tanshinone IIA110Locked
Taurine110Locked
Vitamin B-12110Locked
Vitamin C110Locked
Curcumin24Locked
Gamma-Linoleic Acid (GLA) 24Locked
Resveratrol24Locked
Acetyl-l-carnitine12Locked
Arugula12Locked
Berberine12Locked
Cannabidiol12Locked
Cannabinoids 12Locked
Coenzyme Q1012Locked
Coffee12Locked
Genistein12Locked
Inositol12Locked
Marijuana12Locked
Milk Thistle12Locked
NAC (N-acetyl-L-cysteine)12Locked
Nigella sativa (aka Black Seed)12Locked
Sesamol12Locked
Tarragon12Locked
Thymoquinone12Locked
Trigonelline12Locked
Vitamin E12Locked
Bitter Apple11Locked
Nutmeg11Locked
4 Problem Substances Researched for Diabetic Neuropathies
NameACCKFocus
Organochlorine pesticides110Locked
Persistent organic pollutants (POPs)110Locked
Pesticides110Locked
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)12Locked
7 Therapeutic Actions Researched for Diabetic Neuropathies
NameACCKFocus
Acupuncture330Locked
Transcutaneous electrical nerve stimulation (TENS)120Locked
Photobiomodulation212Locked
Acupressure110Locked
Integrative Medicine110Locked
Reflexology 110Locked
Electroacupuncture12Locked
Related Topics

Diabetic Neuropathies is a Sub of the following Topics

View the Evidence:
47 Abstracts with Diabetic Neuropathies Research

[+]

Palmitoylethanolamide shows promise as a safe and potentially effective adjunctive therapy for diabetic neuropathic pain.May 31, 2026

Pubmed Data : J Diabetes Metab Disord. 2026 Jun ;25(1):52. Epub 2026 Feb 7. PMID: 41664677
Article Published Date : May 31, 2026
Study Type : Meta Analysis, Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Diabetic Neuropathies, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

TENS therapy may be an effective and safe strategy in treatment of symptomatic diabetic peripheral neuropathy.Jul 01, 2010

Pubmed Data : Diabetes Res Clin Pract. 2010 Jul;89(1):10-5. Epub 2010 May 26. PMID: 20510476
Article Published Date : Jul 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetic Neuropathies, Peripheral Neuropathies
Therapeutic Actions : Transcutaneous electrical nerve stimulation (TENS)
[+]

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.Sep 01, 2005

Pubmed Data : J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. PMID: 16112498
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Substances : Ascorbyl Palmitate, Quercetin, Vitamin C, Vitamin D
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies, Peripheral Neuropathies
Pharmacological Actions : Enzyme Inhibitors
[+]

Acetyl-l-carnitine is effective and well tolerated in improving neurophysiological parameters and in reducing pain in patients with diabetic neuropathy. Jan 01, 2002

Pubmed Data : Drugs R D. 2002;3(4):223-31. PMID: 12455197
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Substances : Carnitine, Acetyl-L-
Diseases : Diabetic Neuropathies
[+]

Acetyl-l-carnitine shows promise in the treatment of diabetic peripheral neuropathy. Jan 01, 2007

Pubmed Data : CNS Drugs. 2007;21 Suppl 1:13-23; discussion 45-6. PMID: 17696589
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathies, Peripheral Neuropathies
Pharmacological Actions : Neuritogenic
Additional Keywords : Nerve Regeneration
[+]

Acupressure therapy inhibits the development of diabetic complications in patients with type 2 diabetes. Sep 01, 2009

Pubmed Data : J Altern Complement Med. 2009 Sep;15(9):1027-32. PMID: 19757980
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathies
Therapeutic Actions : Acupressure
[+]

Acupuncture could bring benefit as an additional treatment for people with diabetic painful neuropathy.May 31, 2014

Pubmed Data : Acupunct Med. 2014 Jun ;32(3):242-9. Epub 2014 Mar 21. PMID: 24657491
Article Published Date : May 31, 2014
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathies
Therapeutic Actions : Acupuncture, Integrative Medicine
Pharmacological Actions : Antihypertensive Agents
[+]

Acupuncture has therapeutic effects on diabetic neuropathies. Mar 01, 2006

Pubmed Data : Zhongguo Zhen Jiu. 2006 Mar;26(3):225-6. PMID: 16570451
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathies
Therapeutic Actions : Acupuncture
[+]

Acupuncture has therapeutic value in the treatment of diabetic peripheral neuropathy. Jun 01, 2010

Pubmed Data : J Acupunct Meridian Stud. 2010 Jun;3(2):95-103. PMID: 20633522
Article Published Date : Jun 01, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathies, Peripheral Neuropathies
Therapeutic Actions : Acupuncture
[+]

Alpha Lipoic Acid has therapeutic benefits in the treatment of diabetic neuropathy - Article 1Jan 01, 2008

Pubmed Data : Med Arh. 2008;62(1):45-8. PMID: 18543755
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathies
[+]

Benfotiamine reduces polyneuropathy symptoms. - Article 2Feb 01, 2005

Pubmed Data : Int J Clin Pharmacol Ther. 2005 Feb;43(2):71-7. PMID: 15726875
Article Published Date : Feb 01, 2005
Study Type : Human Study
Additional Links
Substances : Benfotiamine
Diseases : Diabetic Neuropathies
[+]

Biotin improves diabetic peripheral neuropathy. Jan 01, 1990

Pubmed Data : Biomed Pharmacother. 1990;44(10):511-4. PMID: 2085665
Article Published Date : Jan 01, 1990
Study Type : Human Study
Additional Links
Substances : Biotin
Diseases : Diabetic Neuropathies, Peripheral Neuropathies
[+]

Complementary homeopathic therapy of diabetic neuropathy was feasible and promising effects in symptom scores and cost savings were observed.Dec 31, 2008

Pubmed Data : Homeopathy. 2009 Jan ;98(1):17-25. PMID: 19135955
Article Published Date : Dec 31, 2008
Study Type : Human Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies
Additional Keywords : Significant Treatment Outcome
[+]

Effect analysis of tanshinone IIA sulfonate sodium combined with a-lipoic acid in patients with diabetes peripheral neuropathy.Apr 30, 2024

Pubmed Data : Pak J Pharm Sci. 2024 May ;37(3):621-626. PMID: 39340853
Article Published Date : Apr 30, 2024
Study Type : Human Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Neuropathies, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Effect of photobiomodulation on serum neuron specific enolase (NSE) among patients with diabetic peripheral neuropathy.Dec 31, 2019

Pubmed Data : Diabetes Metab Syndr. 2020 ;14(5):1061-1063. Epub 2020 Jun 30. PMID: 32645648
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Neuroprotective Agents
[+]

Inhaled cannabis demonstrated a dose dependent reduction in diabetic peripheral neuropathy pain in patients with treatment refractory pain.Jun 30, 2015

Pubmed Data : J Pain. 2015 Jul ;16(7):616-27. Epub 2015 Apr 3. PMID: 25843054
Article Published Date : Jun 30, 2015
Study Type : Human Study
Additional Links
Substances : Cannabis, Delta-tetrahydrocannabinol (THC)
Diseases : Diabetic Neuropathies
Pharmacological Actions : Analgesics
Additional Keywords : Dose Response, Significant Treatment Outcome
[+]

Lipoic acid improves diabetic neuropathy.Jan 01, 2007

Pubmed Data : Diabetes Educ. 2007 Jan-Feb;33(1):111-7. PMID: 17272797
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathies
[+]

Organochlorine pesticides may be associated with higher risk of peripheral neuropathic complications among those with glucose abnormalities, even beyond the influence of diabetes itself.Nov 01, 2008

Pubmed Data : Diabetes. 2008 Nov;57(11):3108-11. Epub 2008 Jul 22. PMID: 18647952
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Diseases : Diabetes: Glycation/A1C, Diabetic Neuropathies
Problem Substances : Organochlorine pesticides, Persistent organic pollutants (POPs), Pesticides
[+]

Reflexology has a therapeutic effect in diabetics with neuropathy. Dec 31, 2013

Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:843036. Epub 2014 Jan 9. PMID: 24527055
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathies
Therapeutic Actions : Reflexology
[+]

Taurine supplementation may have a protective and/or restorative role in diabetic complications such as neuropathy. Sep 01, 2009

Pubmed Data : Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E620-8. Epub 2009 Jul 14. PMID: 19602579
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : Taurine
Diseases : Diabetic Neuropathies
[+]

Vitamin B12 is superior to the drug Nortriptyline in the treatment of diabetic neuropathy.Jan 01, 2009

Pubmed Data : Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. Epub 2009 Feb 11. PMID: 19212856
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Diabetic Neuropathies, Peripheral Neuropathies
Pharmacological Actions : Anticonvulsants
Additional Keywords : Drug: Nortriptyline, Superiority of Natural Substances versus Drugs
[+]

Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with Type 2 diabetes.May 06, 2016

Pubmed Data : Diabetes Metab Res Rev. 2016 May 7. Epub 2016 May 7. PMID: 27155442
Article Published Date : May 06, 2016
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies, Vitamin D Deficiency
Additional Keywords : Increased Risk
[+]

Vitamin D deficiency is an independent risk factor for peripheral neuropathy.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : F1000Res. 2021 ;10:817. Epub 2021 Aug 16. PMID: 35222988
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Diabetic Neuropathies
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Risk Factors
[+]

A combination of gamma linolenic acid and alpha lipoic acid is effective against multiple indices of experimental diabetic neuropathy.Jul 01, 1998

Pubmed Data : Diabetologia. 1998 Jul;41(7):839-43. PMID: 9686927
Article Published Date : Jul 01, 1998
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathies
Pharmacological Actions : Antioxidants
[+]

Antioxidant and gamma linolenic acid have a protective effect against nerve and vascular dysfunction in experimental diabetes. Sep 01, 1999

Pubmed Data : Diabetes Res Clin Pract. 1999 Sep;45(2-3):137-46. PMID: 10588366
Article Published Date : Sep 01, 1999
Study Type : Animal Study
Additional Links
Substances : Acetyl-l-carnitine, Alpha-Lipoic Acid, Gamma-Linoleic Acid (GLA) , Vitamin E
Diseases : Diabetes: Cardiovascular Illness, Diabetic Neuropathies
Pharmacological Actions : Antioxidants
[+]

Berberine ameliorates diabetic neuropathy.Nov 08, 2017

Pubmed Data : Am J Chin Med. 2017 Nov 9:1-15. Epub 2017 Nov 9. PMID: 29121795
Article Published Date : Nov 08, 2017
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathies
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Berberine, Berberine ameliorates diabetic neuropathy, berberine substance, gmi berberine, gmi berberine substance, GreenMedInfo Berberine, GreenMedInfo Berberine ameliorates diabetic neuropathy
[+]

Cannabinoids demonstrated antinociceptive effects in this mouse model of diabetic peripheral neuropathy.Mar 16, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pain. 2010 Mar 17 ;6:16. Epub 2010 Mar 17. PMID: 20236533
Article Published Date : Mar 16, 2010
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabinoids
Diseases : Brain: Microglial Activation, Diabetic Neuropathies, Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

Cannabis sativa extract attenuates diabetic neuropathic pain in rats. May 13, 2009

Pubmed Data : Phytother Res. 2009 May 13;23(12):1678-1684. PMID: 19441010
Article Published Date : May 13, 2009
Study Type : Animal Study
Additional Links
Substances : Marijuana
Diseases : Diabetic Neuropathies
[+]

Coenzyme q10 has positive effects on diabetic neuropathy in rats. Jun 01, 2008

Pubmed Data : Methods Find Exp Clin Pharmacol. 2008 Jun;30(5):367-74. PMID: 18806896
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Diabetic Neuropathies
[+]

Coffee consumption may have a protective/restorative function on diabetic auditory neuropathy. Aug 29, 2008

Pubmed Data : Neurosci Lett. 2008 Aug 29;441(3):302-6. Epub 2008 Jun 22. PMID: 18586072
Article Published Date : Aug 29, 2008
Study Type : Animal Study
Additional Links
Substances : Coffee, Trigonelline
Diseases : Auditory neuropathy , Diabetic Neuropathies
[+]

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.May 01, 2006

Pubmed Data : Eur J Pharmacol. 2006 May 1;536(3):256-61. Epub 2006 Mar 13. PMID: 16584726
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Neuropathies, Hyperalgesia
Pharmacological Actions : Analgesics, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Photochem Photobiol Sci. 2021 Feb ;20(2):293-301. Epub 2021 Feb 18. PMID: 33721255
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1, Diabetic Neuropathies
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Neuroprotective Agents
[+]

Electroacupuncture improves peripheral neuropathy.Apr 24, 2024

Pubmed Data : Zhen Ci Yan Jiu. 2024 Apr 25 ;49(4):349-357. PMID: 38649202
Article Published Date : Apr 24, 2024
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

Eruca sativa meal against diabetic neuropathic pain: An H2S-mediated effect of glucoerucin.Jan 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 08 19 ;24(16). Epub 2019 Aug 19. PMID: 31430978
Article Published Date : Jan 18, 2019
Study Type : Animal Study
Additional Links
Substances : Arugula
Diseases : Diabetic Neuropathies
Pharmacological Actions : Analgesics
[+]

Genistein relieves neuropathic pain following chronic sciatic nerve injury in mice. Oct 01, 2008

Pubmed Data : J Neurochem. 2008 Oct;107(1):230-40. Epub 2008 Aug 8. PMID: 18691380
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Diabetic Neuropathies, Sciatica
[+]

GLA has a beneficial effect in the sciatic nerve of diabetic rats. Jul 01, 1999

Pubmed Data : J Nutr Biochem. 1999 Jul;10(7):411-20. PMID: 15539317
Article Published Date : Jul 01, 1999
Study Type : Animal Study
Additional Links
Substances : Gamma-Linoleic Acid (GLA)
Diseases : Diabetic Neuropathies, Sciatic Neuralgia
[+]

Mannan-binding lectin (MBL) is involved in the development of diabetic nephropathy.May 07, 2012

Pubmed Data : . PMID: Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model.
Article Published Date : May 07, 2012
Study Type : Animal Study
Additional Links
Diseases : Diabetic Neuropathies
Additional Keywords : Mannan-binding Lectin (MBL)
[+]

Myo-inositol prevents diabetic neuropathy in the rat model of diabetes. - Article 1Feb 01, 1997

Pubmed Data : Diabetes. 1997 Feb;46(2):301-6. PMID: 9000708
Article Published Date : Feb 01, 1997
Study Type : Animal Study
Additional Links
Substances : Inositol
Diseases : Diabetic Neuropathies
[+]

N-acetyl cysteine has a therapeutic role in attenuation of diabetic neuropathy in an animal experimental model. Oct 15, 2009

Pubmed Data : J Neurochem. 2009 Oct 15. PMID: 19840221
Article Published Date : Oct 15, 2009
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Diabetic Neuropathies
[+]

Nigella sativa oil and Thymoquinone correct STZ-diabetes-induced alterations in CK-MB and brain monoamines due to their antioxidant properties.Dec 31, 2008

Pubmed Data : Pharmacology. 2009 ;84(3):127-34. Epub 2009 Aug 13. PMID: 19684436
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetic Neuropathies, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Resveratrol and curcumin may combine with insulin in attenuating diabetic neuropathic pain.Mar 01, 2007

Pubmed Data : Phytother Res. 2007 Mar;21(3):278-83. PMID: 17199240
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Diabetic Neuropathies, Pain
Pharmacological Actions : Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts, Stilbenes
[+]

Resveratrol has therapeutic value in the treatment of diabetic neuropathy, as indicated by an animal experimental model. Mar 06, 2007

Pubmed Data : Life Sci. 2007 Mar 6;80(13):1236-44. Epub 2007 Jan 20. PMID: 17289084
Article Published Date : Mar 06, 2007
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Diabetic Neuropathies
[+]

Sesamol suppresses neuropathic pain associated with diabetes.Oct 01, 2010

Pubmed Data : J Pain. 2010 Oct ;11(10):950-7. Epub 2010 Apr 24. PMID: 20418182
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Diabetic Neuropathies, Inflammation, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Caspase-3 Inhibition
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Silymarin, a compound found within milk thistle seed, amerliorate diabetic neuropathy in a rat experimental model. Dec 03, 2009

Pubmed Data : Phytother Res. 2009 Dec 3. PMID: 19960427
Article Published Date : Dec 03, 2009
Study Type : Animal Study
Additional Links
Substances : Milk Thistle
Diseases : Diabetic Neuropathies
[+]

Tarragon (Artemisia d.) prevents neuropathy in an animal model of high-fat diet-induced prediabetes and obesity.Jan 01, 2010

Pubmed Data : Mediators Inflamm. 2010;2010:268547. Epub 2010 Apr 8. PMID: 20396384
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Tarragon
Diseases : Diabetic Neuropathies
Additional Keywords : Plant Extracts
[+]

Lipoic acid improves diabetic cardiac autonomic neuropathy. Jan 01, 2004

Pubmed Data : Treat Endocrinol. 2004;3(1):41-52. PMID: 15743112
Article Published Date : Jan 01, 2004
Study Type : Review
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathies
[+]

Topical treatments for diabetic neuropathic pain.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Mar ;17(3):1963-1976. Epub 2019 Jan 15. PMID: 30783472
Article Published Date : Feb 28, 2019
Study Type : Review
Additional Links
Substances : Bitter Apple, Nutmeg
Diseases : Diabetic Neuropathies
Pharmacological Actions : Analgesics

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