Diabetic Retinopathy

Name	AC	CK
Vitamin D	6	44
Curcumin	10	22
Magnesium	3	21
Ginsenosides	7	13
Grape Seed Extract	2	12
Omega-3 Fatty Acids	3	12
Goji	8	11
Astaxanthin	8	10
Beta-glucan	1	10
Garlic	1	10
Genipin	1	10
Lutein	8	10
Polyunsaturated Fatty Acids (PUFAs)	1	10
Proanthocyanidins	1	10
Berberine	6	9
Astragaloside	5	8
Puerarin	5	8
Anthocyanins	4	6
Flavonoids	4	6
Quercetin	4	6
Resveratrol	4	6
Apocynin	2	5
Fucoxanthin	1	5
Zeaxanthin	5	5
Alpha-Lipoic Acid	3	4
Ginkgo biloba	3	4
Hydrogen Water	2	4
Kaempferol	2	4
Melatonin	2	4
Myricetin	2	4
Polyphenols	3	4
Pterostilbene	2	4
Sesamin	2	4
Tanshinone IIA	3	4
Zerumbone	2	4
Bee Propolis	2	3
Burdock	2	3
Chrysin	2	3
Eriodictyol	2	3
Ferulic acid	1	3
Hesperidin	3	3
Icariin	1	3
NAC (N-acetyl-L-cysteine)	2	3
Naringenin	2	3
Palmitoylethanolamide	2	3
Peony	2	3
Saffron	2	3
Selenium	2	3
Vitamin C	3	3
Acai	1	2
Andrographis	1	2
Artemisinin	1	2
Asiatic Acid	1	2
Beta-Elemene	1	2
Betaine	1	2
Bilberry	1	2
Biochanin A	1	2
Blueberry	2	2
Caffeic acid phenethyl ester	1	2
Cannabidiol	1	2
Carnosine	1	2
Chinese Skullcap	1	2
Citrus naringin	1	2
Crocin	2	2
Diosgenin	1	2
EGCG (Epigallocatechin gallate)	2	2
Epicatechin	1	2
Gallic Acid	1	2
Genistein	1	2
Gotu Kola	1	2
Huperzine	1	2
Hydroxytyrosol	1	2
Lychee	1	2
Neem	1	2
Panax Notoginseng	1	2
Plantago asiatica	1	2
Pomegranate	1	2
Safflower	1	2
Salvia miltiorrhiza	1	2
Shikonin	1	2
Silibinin	1	2
Sweet Potato: Purple	1	2
Thymoquinone	1	2
Triphala	1	2
Turmeric	1	2
Urolithin A	1	2
Verbascoside	2	2
Walnut	1	2
White Mulberry	1	2
Apigenin	1	1
Capsaicin	1	1
Carotenoids	1	1
Crocetin	1	1
Cyanidin 3-glucoside	1	1
Deguelin	1	1
Diosmin	1	1
Fisetin	1	1
Formononetin	1	1
Gastrodin	1	1
Hawthorn	1	1
Licorice	1	1
Mangiferin	1	1
Perilla	1	1
Procyanidin B2	1	1
Riboflavin (Vitamin B-2)	1	1
Safranal	1	1
Sweet Potato	1	1
Thiamine (B-1)	1	1
Vitamin B12	1	1
Vitamin B6	1	1
Vitamin E	1	1

Name	AC	CK
Photobiomodulation	7	14
Hyperbaric Treatment	1	10
Laser Treatment: Yellow	1	10
Infrared Light	1	3
Light Therapy: Red Colored	1	3

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Adequate vitamin D status, 25(OH)D concentrations may be associated with reduced odds of diabetic retinopathy.Dec 31, 2015

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Pubmed Data : Cardiovasc Diabetol. 2016 ;15(1):128. Epub 2016 Sep 1. PMID: 27586865

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Pubmed Data : Clin Ophthalmol. 2010;4:1201-6. Epub 2010 Oct 21. PMID: 21060672

Article Published Date : Jan 01, 2010

Study Type : Human Study

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Substances : Curcumin

Diseases : Diabetic Retinopathy, Dry Eye Syndromes, Eye Diseases, Glaucoma, Maculopathy, Maculopathy: Age-Related, Uveitis

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Diabetic retinopathy patients with adequate magnesium intake exhibited a lower incidence of all-cause mortality.Jun 30, 2024

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Pubmed Data : Magnes Res. 2024 Jul 1 ;37(1):22-32. PMID: 39077821

Article Published Date : Jun 30, 2024

Study Type : Human Study

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Substances : Magnesium

Diseases : All-Cause Mortality, Diabetic Retinopathy

Additional Keywords : Risk Reduction

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Genipin protects against mitochondrial damage of the retinal pigment epithelium under hyperglycemia.Apr 30, 2022

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Pubmed Data : Ann Transl Med. 2022 May ;10(10):587. PMID: 35722358

Article Published Date : Apr 30, 2022

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Pubmed Data : Antioxidants (Basel). 2023 Feb 25 ;12(3). Epub 2023 Feb 25. PMID: 36978824

Article Published Date : Feb 24, 2023

Study Type : Human Study

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Diseases : Diabetic Retinopathy, Vitamin C Deficiency

Additional Keywords : Risk Factors

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Magnesium deficiency is associated with increased risk of diabetic retinopathy and poor glycemic control.Apr 30, 2019

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Pubmed Data : J Family Med Prim Care. 2019 May ;8(5):1671-1677. PMID: 31198735

Article Published Date : Apr 30, 2019

Study Type : Human Study

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Substances : Magnesium

Diseases : Diabetes Mellitus: Type 2, Diabetic Retinopathy, Magnesium Deficiency

Pharmacological Actions : Renoprotective

Additional Keywords : Risk Factors

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Pubmed Data : Biochim Biophys Acta. 2015 Apr ;1850(4):824-31. Epub 2015 Jan 29. PMID: 25641276

Article Published Date : Mar 31, 2015

Study Type : Animal Study

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Substances : Andrographis

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Antioxidant-rich extract from plantaginis semen Ameliorates diabetic retinal injury in a streptozotocin-induced diabetic rat model.Sep 17, 2016

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Pubmed Data : Nutrients. 2016 Sep 18 ;8(9). Epub 2016 Sep 18. PMID: 27649243

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Pubmed Data : Mol Med Rep. 2015 Aug ;12(2):1639-44. Epub 2015 Apr 15. PMID: 25891515

Article Published Date : Jul 31, 2015

Study Type : Animal Study

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Substances : Betaine

Diseases : Diabetic Retinopathy

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

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Blueberry anthocyanins extract attenuated diabetic retinopathy.Aug 31, 2022

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Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:9817932. Epub 2020 May 30. PMID: 32595756

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Gotu Kola

Diseases : Diabetic Retinopathy

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

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Pubmed Data : Br J Ophthalmol. 2024 Jun 20 ;108(7):989-998. Epub 2024 Jun 20. PMID: 37339867

Article Published Date : Jun 19, 2024

Study Type : Animal Study

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Substances : Huperzine

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Apoptotic

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The present study demonstrated that CAPE treatment may decrease the oxidative stress in the retina.Jun 23, 2021

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Pubmed Data : Cutan Ocul Toxicol. 2021 Jun 24:1-6. Epub 2021 Jun 24. PMID: 34165369

Article Published Date : Jun 23, 2021

Study Type : Animal Study

Additional Links

Substances : Caffeic acid phenethyl ester

Diseases : Diabetes: Oxidative Stress, Diabetic Retinopathy

Pharmacological Actions : Antioxidants

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The results show β-elemene protect the retina of diabetic rats from high glucose damage.Dec 31, 2018

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Pubmed Data : Sci Rep. 2017 Mar 21 ;7:44985. Epub 2017 Mar 21. PMID: 28322323

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Pubmed Data : J Agric Food Chem. 2019 Jul 31 ;67(30):8348-8360. Epub 2019 Jul 19. PMID: 31304751

Article Published Date : Jul 30, 2019

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Diabetic Retinopathy

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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This is the first study demonstrating the protective effects of chrysin on the diabetes-associated malfunctioned visual cycle.Aug 07, 2018

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Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Walnut

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Zerumbone attenuates the severity of retinal inflammation and angiogenesis.Dec 10, 2016

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Pubmed Data : Molecules. 2016 Dec 11 ;21(12). Epub 2016 Dec 11. PMID: 27973425

Article Published Date : Dec 10, 2016

Study Type : Animal Study

Additional Links

Substances : Zerumbone

Diseases : Advanced Glycation End products (AGE), Diabetic Complications, Diabetic Retinopathy

Pharmacological Actions : Angiogenesis Inhibitors, Hypoglycemic Agents, Hypolipidemic, NF-kappaB Inhibitor

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Zerumbone protects against hyperglycemia-induced retinal damage in experimental diabetic rats.Jul 24, 2016

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Pubmed Data : Nutrients. 2016 Jul 25 ;8(8). Epub 2016 Jul 25. PMID: 27463726

Arctiin attenuates high glucose-induced human retinal capillary endothelial cell proliferation.Apr 30, 2020

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Pubmed Data : J Cell Mol Med. 2020 May ;24(10):5695-5706. Epub 2020 Apr 16. PMID: 32297701

Article Published Date : Apr 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Burdock

Diseases : Diabetic Retinopathy

Pharmacological Actions : Antiproliferative , Cell cycle arrest

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Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of actions.Jan 22, 2020

Article Published Date : Mar 31, 2017

Study Type : In Vitro Study

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Substances : Crocin

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents

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Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties.Jan 05, 2020

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Pubmed Data : Exp Eye Res. 2023 Jun ;231:109494. Epub 2023 May 5. PMID: 37149278

Article Published Date : May 31, 2023

Study Type : Review

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Diabetic Retinopathy, Oxidative Stress

Pharmacological Actions : Antioxidants

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Diosmin may be a candidate for preventing the visual impairment caused by diabetic retinopathy.Dec 17, 2017

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Pubmed Data : Molecules. 2017 Dec 18 ;22(12). Epub 2017 Dec 18. PMID: 29258224

Article Published Date : Dec 17, 2017

Study Type : In Vitro Study

Additional Links

Substances : Diosmin

Diseases : Diabetic Retinopathy, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

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Effects of Lycium barbarum polysaccharides on vascular retinopathy.Aug 30, 2022

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Pubmed Data : Sci Rep. 2017 Jul 31 ;7(1):6885. Epub 2017 Jul 31. PMID: 28761134

Article Published Date : Jul 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Diabetic Retinopathy

Pharmacological Actions : Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Hesperidin may protect RGC-5 cells from high glucose-induced injury.Dec 01, 2017

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Pubmed Data : Front Endocrinol (Lausanne). 2022 ;13:945446. Epub 2022 Nov 16. PMID: 36465659

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Safranal

Diseases : Diabetic Retinopathy

Pharmacological Actions : Prophylactic Agents

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Selenium protects ARPE-19 and ACBRI 181 cells against high glucose-induced oxidative stress.Aug 08, 2023

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Pubmed Data : Mol Med Rep. 2020 Nov ;22(5):4227-4235. Epub 2020 Sep 14. PMID: 33000205

Article Published Date : Oct 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

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Therapeutic potential of curcumin in eye diseases.Dec 31, 2018

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Diabetic Retinopathy is a Sub of the following Topic

View the Evidence: 202 Abstracts with Diabetic Retinopathy Research

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This meta-analysis indicates an association between vitamin D deficiency and an increased risk of diabetic retinopathy in type 2 diabetes patients.Mar 19, 2017

Adequate vitamin D status, 25(OH)D concentrations may be associated with reduced odds of diabetic retinopathy.Dec 31, 2015

Association between air pollution exposure and diabetic retinopathy among diabetics.Nov 22, 2019

Beta-glucan, but not vitamin D or placebo, results in significant improvements of natural killer cell numbers.Apr 04, 2020

Curcumin has therapeutic value in the treatment of recurrent anterior uveitis of different etiologies. Jan 01, 2010

Diabetic retinopathy patients with adequate magnesium intake exhibited a lower incidence of all-cause mortality.Jun 30, 2024

Genipin protects against mitochondrial damage of the retinal pigment epithelium under hyperglycemia.Apr 30, 2022

Hyperbaric oxygen therapy may improve diabetic retinopathy and diabetic macular edema.Dec 08, 2019

Intake of dietary LCω3PUFA is associated with a decreased risk of sight-threatening diabetic retinopathy.Aug 17, 2016

Low vitamin C status in pregnancy could be associated with progression of diabetic retinopathy.Feb 24, 2023

Magnesium deficiency is associated with increased risk of diabetic retinopathy and poor glycemic control.Apr 30, 2019

Oral grape seed proanthocyanidin extract therapy for 1 year improved hard exudates in patients with non-proliferative diabetic retinopathy.Apr 30, 2019

Patient comfort with yellow (577 nm) vs. green (532 nm) laser panretinal photocoagulation for proliferative diabetic retinopathy.Jan 31, 2018

This trial suggests that garlic supplements can improve visual acuity, decrease the CMT and lower the IOP.Dec 31, 2021

Vitamin D deficiency is considered as a risk factor for diabetic retinopathy and hearing loss among diabetic patients.Dec 31, 2017

Vitamin D deficiency is significantly associated with risk of proliferative diabetic retinopathy.Oct 31, 2019

Fucoxanthin reduced the inflammation response and maintained the integrity of the blood-retinal barrier.Nov 24, 2020

Apocynin protects retina cells from ultraviolet radiation damage.Feb 29, 2020

Astragaloside IV protects renal tubular epithelial cells against oxidative stress-induced injury.Jul 21, 2024

Ferulic acid attenuates high glucose-induced apoptosis in retinal pigment epithelium cells.Dec 31, 2021

Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.May 27, 2024

Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy.Apr 14, 2024

Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy.Apr 30, 2013

Smart wireless near-infrared light emitting contact lens for the treatment of diabetic retinopathy.Feb 28, 2022

4D-DIA quantitative proteomics revealed the core mechanism of diabetic retinopathy after berberine treatment.Aug 30, 2023

670nm photobiomodulation modulates bioenergetics and oxidative stress, in rat Müller cells challenged with high glucose.Dec 31, 2020

A compound in Chinese skullcap known as baicalein reduces the inflammatory process in a rodent model of diabetic retinopathyMay 01, 2009

Administration of biochanin A can improve and postpone retinopathy.Nov 30, 2018

Alpha-lipoic acid reduces retinal cell death in diabetic mice.Jul 10, 2018

Analysis of lipid peroxidation by UPLC-MS/MS and retinoprotective effects of the natural polyphenol pterostilbene.Jan 22, 2021

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation.Mar 31, 2015

Antioxidant-rich extract from plantaginis semen Ameliorates diabetic retinal injury in a streptozotocin-induced diabetic rat model.Sep 17, 2016

Apocynin ameliorates diabetic retinopathy in rats: Involvement of TLR4/NF-κB signaling pathway.Jul 31, 2019

Asiatic acid attenuates diabetic retinopathy.Jul 14, 2021

Astaxanthin inhibits aldose reductase activity in Psammomys obesus, a model of type 2 diabetes and diabetic retinopathy.Nov 30, 2019

Astaxanthin inhibits oxidative stress and apoptosis in diabetic retinopathy.Jul 31, 2023

Astragaloside IV protects retinal pigment epithelial cells from apoptosis by upregulating miR-128 expression.Jun 30, 2020

Berberine alleviates diabetic retinopathy by regulating the Th17/Treg ratio.Apr 30, 2024

Berberine improves insulin-induced diabetic retinopathy in type I and II diabetes.Dec 31, 2020

Betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes.Jul 31, 2015

Blueberry anthocyanins extract attenuated diabetic retinopathy.Aug 31, 2022

Carnosine improves diabetic retinopathy via the MAPK/ERK pathway.Mar 31, 2019

CBD's anti-inflammatory effects are linked to the inhibition of adenosine uptake.Nov 30, 2008

Curcumin attenuates retinal oxidative stress and inflammation in diabetes.Jan 01, 2007

Curcumin may have a preventive role in the treatment of diabetic retinopathy. Sep 21, 2007

Curcumolide reduces diabetic retinal vascular leukostasis.Apr 14, 2017

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.Mar 14, 2013

Diosgenin alleviates the progression of diabetic retinopathy.Dec 31, 2022

Effects of compound centella on oxidative stress and keap1-Nrf2-ARE pathway expression in diabetic kidney disease.Dec 31, 2019

Epicatechin was able to break preformed glycated human serum albumin in vitro as well as reduce AGE accumulation in retinas in vivo in a dose dependent manner.Feb 04, 2015

Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.Jun 30, 2012

Ethanol extract of Chinese propolis attenuates early diabetic retinopathy.Jan 31, 2019

Gallic acid and myricetin-rich Labisia pumila extract mitigated multiple diabetic eye disorders in rats.Oct 06, 2021

Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation.Jan 01, 2010

Ginsenoside Rb1 inhibited high glucose-induced oxidative stress, DNA damage, and cell apoptosis in cultured retinal capillary endothelial cells.Oct 04, 2019

Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.Feb 08, 2022

Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina.Dec 31, 2009

Huperzine A might be a potential therapeutic drug to prevent diabetic retinopathy.Jun 19, 2024

Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats.Feb 28, 2013

Hydroxysafflor yellow A improved retinopathy via Nrf2/HO-1 pathway.Dec 31, 2021

Hydroxytyrosol exerted a neuroprotective effect on diabetic retinopathy.Jan 23, 2018

Long-term lutein administration attenuates retinal inflammation and functional deficits in early diabetic retinopathy.Jun 30, 2020

Low-level laser therapy with 670 nm alleviates diabetic retinopathy in an experimental model.Dec 31, 2020

Lychee seed polyphenol ameliorates diabetic retinopathy via inhibiting inflammasome/apoptosis and angiogenesis.Oct 31, 2023

Lycium barbarum polysaccharides Improve diabetic retinopathy.Dec 31, 2017

M. alba has protective effect on diabetic retinopathy.Apr 07, 2016

Melatonin can exert receptor-mediated signaling effects to attenuate inflammation and oxidative stress of the retina. Dec 31, 2015

Melatonin treatment could be a novel therapeutic strategy for diabetic retinopathy.Apr 22, 2020

Myricetin inhibits advanced glycation end product-induced migration of retinal pericytesFeb 14, 2015

N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice.Jun 04, 2021

Naringenin provides neurotrophic support to prevent retinal damage in diabetic retinopathy.Oct 23, 2017

Naringin attenuates diabetic retinopathy by inhibiting inflammation and oxidative stress.Jun 30, 2017

Diabetic Retinopathy

View the Evidence:
202 Abstracts with Diabetic Retinopathy Research