Down Syndrome

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13 Substances Researched for Down Syndrome
NameACCKFocus
EGCG (Epigallocatechin gallate)834Locked
Green Tea212Locked
Alpha-Lipoic Acid110Locked
Coenzyme Q10110Locked
Vitamin E: alpha tocopherol110Locked
Choline12Locked
Curcumin12Locked
Fish Oil12Locked
Luteolin12Locked
Resveratrol12Locked
Catechin 11Locked
NAC (N-acetyl-L-cysteine)11Locked
Polyphenols11Locked
4 Problem Substances Researched for Down Syndrome
NameACCKFocus
Gliadin550Locked
Wheat220Locked
Gluten110Locked
Thimerosal 11Locked
3 Therapeutic Actions Researched for Down Syndrome
NameACCKFocus
Exercise: Cycling110Locked
Dietary Modification: Low Carbohydrate/Ketogenic13Locked
Photobiomodulation11Locked

View the Evidence:
28 Abstracts with Down Syndrome Research

[+]

Assisted cycling exercise improves fine manual dexterity in persons with Down's syndrome.Apr 30, 2014

Pubmed Data : J Appl Res Intellect Disabil. 2014 May ;27(3):264-72. Epub 2013 Jun 18. PMID: 23775674
Article Published Date : Apr 30, 2014
Study Type : Human Study
Additional Links
Diseases : Down Syndrome
Therapeutic Actions : Exercise: Cycling
[+]

Celiac disease is a common condition in Down syndrome.Nov 01, 1995

Pubmed Data : J Pediatr Gastroenterol Nutr. 1995 Nov;21(4):443-5. PMID: 8583297
Article Published Date : Nov 01, 1995
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Down Syndrome
Additional Keywords : Diseases that are Linked
Problem Substances : Gliadin, Gluten, Wheat
Adverse Pharmacological Actions : Immunotoxic
[+]

Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.Oct 18, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pediatr (Rio J). 2016 Oct 19. Epub 2016 Oct 19. PMID: 27770619
Article Published Date : Oct 18, 2016
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Down Syndrome, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG and cognitive training for 12 months led to an improving of visual recognition memory, inhibitory control, and adaptive behaviour.Jun 30, 2016

Pubmed Data : Lancet Neurol. 2016 Jul ;15(8):801-10. PMID: 27302362
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Down Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

The prevalence of celiac disease in Down syndrome in the southeastern United States was 1 in 14 cases.Sep 01, 2000

Pubmed Data : J Pediatr Gastroenterol Nutr. 2000 Sep;31(3):275-9. PMID: 10997372
Article Published Date : Sep 01, 2000
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Down Syndrome
Additional Keywords : Diseases that are Linked
Problem Substances : Gliadin
[+]

There is a higher prevalence of celiac disease in patients with Down syndrome than background populations.Sep 01, 1999

Pubmed Data : Acta Paediatr. 1999 Sep;88(9):953-6. PMID: 10519335
Article Published Date : Sep 01, 1999
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Down Syndrome
Additional Keywords : Diseases that are Linked
Problem Substances : Gliadin
[+]

There is a prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome.Feb 01, 1998

Pubmed Data : Pediatrics. 1998 Feb;101(2):272-5. PMID: 9445503
Article Published Date : Feb 01, 1998
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Down Syndrome, Gluten Sensitivity
Additional Keywords : Diseases that are Linked
Problem Substances : Gliadin, Wheat
[+]

There is an increased frequency of gliadin antibodies in patients with Down syndrome, indicating the possibilty of an increased incidence of celiac disease in this population.Sep 01, 1990

Pubmed Data : Eur J Pediatr. 1990 Sep;149(12):833-4. PMID: 2146127
Article Published Date : Sep 01, 1990
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Down Syndrome, Gluten Sensitivity
Problem Substances : Gliadin
[+]

Usage of and attitudes about green tea extract and epigallocathechin-3-gallate as a therapy in individuals with Down syndrome.Jul 31, 2019

Pubmed Data : Complement Ther Med. 2019 Aug ;45:234-241. Epub 2019 Jul 2. PMID: 31331567
Article Published Date : Jul 31, 2019
Study Type : Human Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Down Syndrome
[+]

α-Tocopherol supplementation of the diets of children with down syndrome may attenuate the oxidative stress at the DNA level.Sep 30, 2014

Pubmed Data : Eur J Clin Nutr. 2014 Oct ;68(10):1119-23. Epub 2014 Jun 18. PMID: 24939437
Article Published Date : Sep 30, 2014
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid, Vitamin E: alpha tocopherol
Diseases : Down Syndrome, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Supplementation
[+]

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome.Jan 01, 2013

Pubmed Data : Biochim Biophys Acta. 2013 Jan 2. Epub 2013 Jan 2. PMID: 23291000
Article Published Date : Jan 01, 2013
Study Type : Human In Vitro
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Down Syndrome
Additional Keywords : Mitochondrial Biogenesis
[+]

A therapeutic ketogenic diet was associated with significant cognitive improvement in this patient with concurrent Down syndrome and dementia.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Psychiatry. 2022 ;13:1085512. Epub 2023 Jan 9. PMID: 36699496
Article Published Date : Dec 31, 2021
Study Type : Human: Case Report
Additional Links
Diseases : Alzheimer's Disease, Down Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

EGCG from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains.Apr 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Apr 4 ;7(1):619. Epub 2017 Apr 4. PMID: 28377597
Article Published Date : Apr 03, 2017
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Down Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

EGCG-containing supplements may be important in correcting skeletal deficits associated with Down syndrome.Jan 08, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Jan 9. Epub 2016 Jan 9. PMID: 26748562
Article Published Date : Jan 08, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Down Syndrome
Additional Keywords : Gene Expression Regulation
[+]

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.Dec 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2009 ;4(2):e4606. Epub 2009 Feb 26. PMID: 19242551
Article Published Date : Dec 31, 2008
Study Type : Transgenic Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Down Syndrome
Pharmacological Actions : Antioxidants
[+]

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2019 Apr ;14(4):613-620. PMID: 30632501
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Down Syndrome
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neurogenesis, Neuroprotective Agents
[+]

Prenatal curcumin administration rescues neuromorphological and cognitive alterations in Ts65Dn down syndrome mice. Jul 29, 2020

Pubmed Data : J Nutr. 2020 Jul 30. Epub 2020 Jul 30. PMID: 32729926
Article Published Date : Jul 29, 2020
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Down Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

Resveratrol and EGCG restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model.Mar 06, 2016

Pubmed Data : Biochim Biophys Acta. 2016 Mar 7. Epub 2016 Mar 7. PMID: 26964795
Article Published Date : Mar 06, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Resveratrol
Diseases : Down Syndrome
[+]

The flavonoid 7,8-DHF fosters prenatal brain proliferation potency in a mouse model of Down syndrome.Jan 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 03 18 ;11(1):6300. Epub 2021 Mar 18. PMID: 33737521
Article Published Date : Jan 17, 2021
Study Type : Animal Study
Additional Links
Diseases : Down Syndrome
[+]

These results suggest the potential use of fish oil in treating Down syndrome.Apr 30, 2015

Pubmed Data : Nutr Res. 2015 May ;35(5):440-8. Epub 2015 Mar 1. PMID: 25799055
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Fish Oil
Diseases : Down Syndrome
Pharmacological Actions : MicroRNA modulator
Additional Keywords : Gene Expression Regulation, Genetic Disorders, Significant Treatment Outcome
[+]

These results support the lifelong attentional benefits of maternal choline supplementation for Ts65Dn and 2N offspring.Nov 09, 2016

Pubmed Data : Neuroscience. 2016 Nov 10. Epub 2016 Aug 10. PMID: 27840230
Article Published Date : Nov 09, 2016
Study Type : Animal Study
Additional Links
Substances : Choline
Diseases : Down Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

Catechins as a potential dietary supplementation in prevention of comorbidities linked with down syndrome.May 11, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 May 12 ;14(10). Epub 2022 May 12. PMID: 35631180
Article Published Date : May 11, 2022
Study Type : Review
Additional Links
Substances : Catechin , Polyphenols
Diseases : Alzheimer's Disease, Down Syndrome, Metabolic Diseases, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model.Feb 04, 2024

Pubmed Data : Eur J Med Chem. 2024 Feb 5 ;265:116098. Epub 2024 Jan 1. PMID: 38171148
Article Published Date : Feb 04, 2024
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Down Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21.Aug 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Aug 30 ;11(1):17377. Epub 2021 Aug 30. PMID: 34462463
Article Published Date : Aug 29, 2021
Study Type : In Vitro Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Alzheimer's Disease, Down Syndrome
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains.Jun 30, 2003

Pubmed Data : Cell Mol Life Sci. 2003 Jul ;60(7):1513-23. PMID: 12943237
Article Published Date : Jun 30, 2003
Study Type : In Vitro Study
Additional Links
Diseases : Down Syndrome, Oxidative Stress
Additional Keywords : Increased Risk
Problem Substances : Thimerosal
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Results of this study showed that WBV training improves muscle strength, BMD, body composition and balance of children and adolescents with Down syndrome.Jan 11, 2018

Pubmed Data : Osteoporos Int. 2018 Jan 12. Epub 2018 Jan 12. PMID: 29330572
Article Published Date : Jan 11, 2018
Study Type : Review
Additional Links
Diseases : Down Syndrome
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This review offers a hypothetical mechanistic link between periodontitis and Alzheimer's disease in the Down syndrome population.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Alzheimers Dement (Amst). 2016 ;2:49-57. Epub 2016 Feb 4. PMID: 27239536
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Down Syndrome, Periodontal Diseases
Additional Keywords : Risk Factors
[+]

Transcranial photobiomodulation for neurodevelopmental disorders.Jul 31, 2024

Pubmed Data : Photochem Photobiol Sci. 2024 Aug ;23(8):1609-1623. Epub 2024 Jul 15. PMID: 39009808
Article Published Date : Jul 31, 2024
Study Type : Review
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorders, Down Syndrome, Neurodevelopmental Disorders
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Neuroprotective Agents

Copyright: alila / 123RF Stock Photo

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