Drug-Induced Nutrient Depletion: Statin Drugs

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3 Substances Researched for Drug-Induced Nutrient Depletion: Statin Drugs
NameACCKFocus
Coenzyme Q10524Locked
Vitamin D110Locked
Selenium11Locked
8 Problem Substances Researched for Drug-Induced Nutrient Depletion: Statin Drugs
NameACCKFocus
Statin Drugs25143Locked
Simvastatin738Locked
Atorvastatin730Locked
Lovastatin322Locked
Pravastatin 212Locked
Fluvastatin110Locked
Cerivastatin11Locked
Fenofibrates11Locked

View the Evidence:
36 Abstracts with Drug-Induced Nutrient Depletion: Statin Drugs Research

[+]

The meta-analysis showed a significant reduction in plasma CoQ10 concentrations following treatment with statins.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2015 Sep ;99:329-36. Epub 2015 Jul 17. PMID: 26192349
Article Published Date : Aug 31, 2015
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs
Additional Keywords : Risk Factors
Problem Substances : Statin Drugs
[+]

"Lipid-lowering drugs and essential omega-6 and omega-3 fatty acids in patients with coronary heart disease."Jan 31, 2005

Pubmed Data : Nutr Metab Cardiovasc Dis. 2005 Feb ;15(1):36-41. PMID: 15871849
Article Published Date : Jan 31, 2005
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease, Dietary Fatty Acid Imbalance: Omega3/Omega6 Ratio, Drug-Induced Nutrient Depletion: Statin Drugs, Omega-3 Fatty Acid Deficiency, Statin-Induced Pathologies
Additional Keywords : Drug Synergy
Problem Substances : Simvastatin, Statin Drugs
[+]

After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.Nov 27, 2012

Pubmed Data : Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519
Article Published Date : Nov 27, 2012
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Death: Statin-Induced, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Coq10 supplementation corrects statin-induced coq10 depletion without affecting the cholesterol lowering effect of simvastatin. Jan 01, 1994

Pubmed Data : Mol Aspects Med. 1994;15 Suppl:s187-93. PMID: 7752830
Article Published Date : Jan 01, 1994
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Additional Keywords : Drug: Simvastatin, Drug-Nutrient Depletion, Statin-Coq10 Depletion
[+]

Fluvastatin has been linked to adverse hepatic reactions.Jan 01, 2006

Pubmed Data : Drug Saf. 2006 ;29(12):1163-72. PMID: 17147462
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Drug-Induced Nutrient Depletion: Statin Drugs
Problem Substances : Fluvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Lovastatin decreases coenzyme Q levels associated with compromised cardiac function in humans.Nov 01, 1990

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8931-4. PMID: 2247468
Article Published Date : Nov 01, 1990
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease, Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Low serum vitamin D levels are associated with reversible myositis-myalgia in statin-treated patients.Jan 01, 2009

Pubmed Data : Transl Res. 2009 Jan;153(1):11-6. Epub 2008 Dec 6. PMID: 19100953
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Myalgias, Myositis, Statin-Induced Pathologies, Vitamin D Deficiency
[+]

Statin therapy is associated with decreased serum levels of zinc and copper.Jan 01, 2005

Pubmed Data : J Trace Elem Med Biol. 2005;19(1):61-7. PMID: 16240674
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Copper Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Hyperlipidemia, Statin-Induced Pathologies, Zinc Deficiency
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
[+]

Statin therapy was associated with greater progression of coronary artery calcification.Dec 29, 2016

Pubmed Data : Eur J Clin Invest. 2016 Dec 30. Epub 2016 Dec 30. PMID: 28036114
Article Published Date : Dec 29, 2016
Study Type : Human Study
Additional Links
Diseases : Arterial Calcification, Drug-Induced Nutrient Depletion: Statin Drugs, Vitamin K Deficiency
Additional Keywords : Risk Factors
Problem Substances : Statin Drugs
[+]

Statins may adversely alter the response of muscle to exercise stress.Dec 01, 2005

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Drug-Induced Nutrient Depletion: Statin Drugs, Exercise-Induced Tissue Damage, Muscle Damage: Exercise-Induced
Pharmacological Actions : Proteasome Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
[+]

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs. Jan 01, 1997

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Pharmacological Actions : Antioxidants
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
[+]

This study found that patients with chronic kidney disease and taking statins had lower 25-OH-D3 levels. Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nefrologia. 2015 Mar-Apr;35(2):150-6. Epub 2015 Jun 23. PMID: 26300508
Article Published Date : Feb 28, 2015
Study Type : Human Study
Additional Links
Diseases : Chronic Kidney Disease (CKD), Drug-Induced Nutrient Depletion: Statin Drugs, Vitamin D Deficiency
Problem Substances : Statin Drugs
[+]

Type 2 diabetic patients patients treated with statin drugs have decreased coq10 levels and may be associated with subclinical diabetic cardiomyopathy reversible by CoQ10 supplementation.Apr 01, 1999

Pubmed Data : Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID: 10337451
Article Published Date : Apr 01, 1999
Study Type : Human Study
Additional Links
Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

A case of atorvastatin-induced pancreatitis has been reported.Oct 01, 2010

Pubmed Data : Indian J Pharmacol. 2010 Oct ;42(5):324-5. PMID: 21206629
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Pancreatitis
Problem Substances : Atorvastatin, Statin Drugs
[+]

Atrial fibrillation induced by simvastatin treatment in a 61-year-old man has been reported. Jul 01, 2003

Pubmed Data : Heart Vessels. 2003 Jul ;18(3):157-9. PMID: 12955433
Article Published Date : Jul 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic
[+]

Statin precipitated lactic acidosis has been reported. Sep 01, 2004

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664
Article Published Date : Sep 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Lactic Acidosis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
[+]

Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals.Jul 06, 1994

Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Article Published Date : Jul 06, 1994
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Lovastatin lowers tissue concentrations of CoQ10 which can be rectified by supplementation with CoQ10.Nov 01, 1990

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8928-30. PMID: 2247467
Article Published Date : Nov 01, 1990
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs
Additional Keywords : Statin-Coq10 Depletion
[+]

Mitochondrial parameters including, SDA, ATP levels, MMP and MPP were reduced with statin treatment and improved by co-administration with CoQ10.May 21, 2015

Pubmed Data : Eur J Pharmacol. 2015 May 22 ;762:270-274. Epub 2015 May 22. PMID: 26007644
Article Published Date : May 21, 2015
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs
Pharmacological Actions : Hepatoprotective
Additional Keywords : Supplementation
Problem Substances : Statin Drugs
[+]

Pravastatin accelerates aging effect on diaphragm mitochondrial respiratory function in rats.Dec 01, 1998

Pubmed Data : Biochem Mol Biol Int. 1998 Dec ;46(5):923-31. PMID: 9861446
Article Published Date : Dec 01, 1998
Study Type : Animal Study
Additional Links
Diseases : Aging, Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Respiratory Diseases, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
[+]

Simvastatin decreases coenzyme q10 levels in the left ventricle of the heart and skeletal muscle.Jan 01, 2007

Pubmed Data : Physiol Res. 2007;56 Suppl 2:S49-54. Epub 2007 Sep 5. PMID: 17824807
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases, Drug-Induced Nutrient Depletion: Statin Drugs, Hypertension, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Simvastatin worsens the myocardial mitochondrial respiration during ischemia probably due to depletion of coenzyme Q10. Sep 01, 1995

Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576
Article Published Date : Sep 01, 1995
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Myocardial Ischemia, Statin-Induced Pathologies
Pharmacological Actions : Enzyme Inhibitors
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Statin drugs adversely effect memory likely through depletion of coenzyme q10 and interference with mitochondrial function in the brain. Jul 08, 2011

Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754
Article Published Date : Jul 08, 2011
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs interfere with neurological healing by inhibiting myelin formation. Dec 10, 2008

Pubmed Data : J Neurosci. 2008 Dec 10 ;28(50):13609-14. PMID: 19074034
Article Published Date : Dec 10, 2008
Study Type : Animal Study
Additional Links
Diseases : Demyelinating Diseases, Drug-Induced Nutrient Depletion: Statin Drugs, Multiple Sclerosis
Additional Keywords : Remyelination
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Atorvastin reduces coenzyme Q content and heart mitochondrial function in an animal model. Jan 01, 2011

Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Diseases : Congestive Heart Failure, Drug-Induced Nutrient Depletion: Statin Drugs, Lipid Peroxidation, Mitochondrial Dysfunction
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies.Jan 01, 2010

Pubmed Data : Ochsner J. 2010 ;10(1):16-21. PMID: 21603349
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Coenzyme Q10 may be an effective adjunctive treatment of chronic heart failure. Sep 01, 2009

Pubmed Data : Med Hypotheses. 2009 Sep;73(3):306-8. Epub 2009 May 5. PMID: 19409711
Article Published Date : Sep 01, 2009
Study Type : Review
Additional Links
Substances : Coenzyme Q10
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies
[+]

Muscle cells may be particularly susceptible to a statin-induced suppression of essential antioxidant selenoproteinsOct 19, 2012

Pubmed Data : Toxicol Lett. 2012 Oct 20. Epub 2012 Oct 20. PMID: 23092657
Article Published Date : Oct 19, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Myopathies, Statin-Induced Pathologies
Problem Substances : Cerivastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Simvastatin-induced inhibition of mitochondrial respiration is likely associated myotoxicity. Aug 04, 2011

Pubmed Data : Biochim Biophys Acta. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21839782
Article Published Date : Aug 04, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Mitochondrial Myopathies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs may cause myopathy by lowering vitamin E levels. Nov 05, 2009

Pubmed Data : Med Hypotheses. 2009 Nov 5. Epub 2009 Nov 5. PMID: 19896775
Article Published Date : Nov 05, 2009
Study Type : Review
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies, Vitamin E Deficiency
Additional Keywords : Statin-Vitamin E Deficiency
Problem Substances : Statin Drugs
[+]

Statin drugs may deplete the body of selenoproteins. Dec 21, 2005

Pubmed Data : World J Gastroenterol. 2005 Dec 21;11(47):7466-72. PMID: 19534648
Article Published Date : Dec 21, 2005
Study Type : Review
Additional Links
Substances : Selenium
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium
[+]

Statin drugs may induce selenium deficiency which may explain many of its enigmatic side effects.Mar 13, 2004

Pubmed Data : Lancet. 2004 Mar 13;363(9412):892-4. PMID: 15031036
Article Published Date : Mar 13, 2004
Study Type : Review
Additional Links
Diseases : Coronary Artery Disease, Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs result in coq10 depletion associated with congestive heart failure and which may be rectified by supplementation. Jan 01, 2003

Pubmed Data : Biofactors. 2003;18(1-4):101-11. PMID: 14695925
Article Published Date : Jan 01, 2003
Study Type : Review
Additional Links
Substances : Coenzyme Q10
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies
Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion
[+]

Statin-induced liver injury may result from the suppression of selenoprotein expression.Jun 01, 2009

Pubmed Data : Mol Pharmacol. 2009 Jun;75(6):1421-9. Epub 2009 Mar 30. PMID: 19332511
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Atorvastatin, Statin Drugs
[+]

Statins and fenofibrates may exert their wide range of adverse side effects through interfering with selenoprotein expression.Oct 01, 2004

Pubmed Data : Trends Cardiovasc Med. 2004 Oct;14(7):273-81. PMID: 15542379
Article Published Date : Oct 01, 2004
Study Type : Review
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Drug-Nutrient Depletion, Statin-Selenium Deficiency
Problem Substances : Fenofibrates, Statin Drugs
[+]

Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation and the biosynthesis of selenium containing proteins. Feb 05, 2015

Pubmed Data : Expert Rev Clin Pharmacol. 2015 Feb 6:1-11. Epub 2015 Feb 6. PMID: 25655639
Article Published Date : Feb 05, 2015
Study Type : Commentary
Additional Links
Diseases : Atherosclerosis, Drug-Induced Nutrient Depletion: Statin Drugs
Problem Substances : Statin Drugs

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