Drug-Induced Nutrient Depletion: Vitamin B-12

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1 Substances Researched for Drug-Induced Nutrient Depletion: Vitamin B-12

Name	AC	CK	Focus
Vitamin B-12	3	30

4 Problem Substances Researched for Drug-Induced Nutrient Depletion: Vitamin B-12

Name	AC	CK
Metformin	3	30
Proton-Pump Inhibitors	3	14
Histamine Receptor Antagonists	1	10
Ranitidine	1	10

Research Articles 9
Cumulative Knowledge Score 14
Overall Research Rating GOOD

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9 Abstracts with Drug-Induced Nutrient Depletion: Vitamin B-12 Research

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[+]

Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.Oct 01, 2004

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Pubmed Data : Am J Cardiol. 2004 Oct 1;94(7):975-7. PMID: 15464695

Article Published Date : Oct 01, 2004

Study Type : Human Study

Additional Links

Diseases : Aspirin-Induced Toxicity , Drug-Induced Nutrient Depletion: Aspirin, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Pharmacological Actions : Platelet Aggregation Inhibitors

Additional Keywords : Aspirin-Vitamin b12 Deficiency, Drug-Nutrient Depletion

[+]

Hyperglycemia and metformin use are associated With B vitamin deficiency and cognitive dysfunction in older adults.Sep 30, 2019

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Pubmed Data : J Clin Endocrinol Metab. 2019 Oct 1 ;104(10):4837-4847. PMID: 30920623

Article Published Date : Sep 30, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Additional Keywords : Risk Factors

Problem Substances : Metformin

[+]

Prolonged acid suppression therapy with PPIs or H2 blockers may result in serum vitamin B12 deficiency.Oct 20, 2020

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Pubmed Data : Ir J Med Sci. 2020 Oct 21. Epub 2020 Oct 21. PMID: 33085017

Article Published Date : Oct 20, 2020

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12

Additional Keywords : Increased Risk

Problem Substances : Proton-Pump Inhibitors

[+]

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

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Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642

Article Published Date : Apr 01, 1983

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Acid Reflux, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Pharmacological Actions : Anti-Ulcer Agents

Problem Substances : Histamine Receptor Antagonists, Ranitidine

[+]

The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy.Jan 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sultan Qaboos Univ Med J. 2020 Feb ;20(1):e90-e94. Epub 2020 Mar 9. PMID: 32190375

Article Published Date : Jan 31, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Additional Keywords : Risk Factors

Problem Substances : Metformin

[+]

The prevalence of vitamin B12 deficiency was significantly high in diabetics, especially the metformin-treated patients.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : SAGE Open Med. 2019 ;7:2050312119853433. Epub 2019 May 23. PMID: 31205703

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Additional Keywords : Risk Factors

Problem Substances : Metformin

[+]

Vitamin B12 deficiency and diabetic neuropathy are very high among metformin-treated T2DM patients.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2021 ;16(3):e0249325. Epub 2021 Mar 30. PMID: 33784336

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Drug-Induced Nutrient Depletion: Vitamin B-12

Additional Keywords : Risk Factors

[+]

This case report describes a case of PPI-induced thrombocytopenia.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Case Rep Gastrointest Med. 2018 ;2018:4294805. Epub 2018 Apr 30. PMID: 29854491

Article Published Date : Dec 31, 2017

Study Type : Human: Case Report, Review

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Osteoporosis, Thrombocytopenia

Additional Keywords : Risk Factors

Problem Substances : Proton-Pump Inhibitors

[+]

Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations.Jul 08, 2020

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Pubmed Data : Therapie. 2020 Jul 9. Epub 2020 Jul 9. PMID: 32718584

Article Published Date : Jul 08, 2020

Study Type : Review

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Mineral Deficiencies, Vitamin C Deficiency

Additional Keywords : Increased Risk

Problem Substances : Proton-Pump Inhibitors

Drug-Induced Nutrient Depletion: Vitamin B-12 Related Articles

Vitamin B12 Deficiency and Brain Health

Written by Kelly Brogan, M.D.

One of the most remarkable papers I have read in the psychiatric literature was about a 57 year old woman who was treated with months of both antipsychotic and antidepressant medications and given two rounds of electroconvulsive treatment before anyone bothered to check her vitamin B12 level.

Vitamin B Deficiency: Why Vitamin Pills Are Not Enough

Written by Vic Shayne, Ph.D.

Real foods contain a host of nutrients that vitamin pills do not. And we need these other nutrients — often more than the vitamin itself — for healing, prevention and cellular function.

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View the Evidence: 9 Abstracts with Drug-Induced Nutrient Depletion: Vitamin B-12 Research

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Currently Available Sorting Options

Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.Oct 01, 2004

Hyperglycemia and metformin use are associated With B vitamin deficiency and cognitive dysfunction in older adults.Sep 30, 2019

Prolonged acid suppression therapy with PPIs or H2 blockers may result in serum vitamin B12 deficiency.Oct 20, 2020

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy.Jan 31, 2020

The prevalence of vitamin B12 deficiency was significantly high in diabetics, especially the metformin-treated patients.Dec 31, 2018

Vitamin B12 deficiency and diabetic neuropathy are very high among metformin-treated T2DM patients.Dec 31, 2020

This case report describes a case of PPI-induced thrombocytopenia.Dec 31, 2017

Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations.Jul 08, 2020

Drug-Induced Nutrient Depletion: Vitamin B-12 Related Articles

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Drug-Induced Nutrient Depletion: Vitamin B-12

View the Evidence:
9 Abstracts with Drug-Induced Nutrient Depletion: Vitamin B-12 Research