Drug Toxicity: Methotrexate

Name	AC	CK
Curcumin	4	7
Alpha-Lipoic Acid	3	6
Hesperidin	3	6
Ferulic acid	2	4
Moringa oleifera	2	4
Quercetin	2	4
Streptococcus thermophilus	2	4
Thymoquinone	2	4
Lutein	2	3
Apigenin	1	2
Apricot	1	2
Bee Propolis	1	2
Camel Milk	1	2
Citrus naringin	1	2
Coenzyme Q10	1	2
Crocin	1	2
Diosmin	1	2
Ellagic Acid	1	2
Folic Acid	1	2
Ginkgo biloba	1	2
Indole-3-Carbinol	1	2
Lactobacilius bulgaricus	1	2
Lactoferrin	1	2
Paeonol	1	2
Pomegranate	1	2
Pomegranate Peel	1	2
Pomegranate Seed	1	2
Prickly Pear Cactus	1	2
Puerarin	1	2
Pumpkin Seed Oil/Meal	1	2
Resveratrol	1	2
Silibinin	1	2
Vanillin	1	2
Verbascoside	1	2
Yoghurt	1	2
beta-Carotene	1	2
Lycopene	1	1

Name	AC	CK
Methotrexate	11	23
Infliximab	1	3
Gluten	1	2
Grains	1	2

[+]

A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab has been reported.Nov 01, 2010

Click here to read the entire abstract

Pubmed Data : Arthritis Rheum. 2010 Nov;62(11):3191-5. PMID: 20722036

Article Published Date : Nov 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Drug Toxicity: Methotrexate, Leukoencephalopathy

Problem Substances : Infliximab

[+]

Folic acid has been observed to ameliorate methotrexate induced gynecomastia. Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : Rheumatol Int. 2010 Aug;30(10):1371-2. Epub 2009 Jul 12. PMID: 19597731

Article Published Date : Aug 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Drug Toxicity: Methotrexate, Gynecomastia: Methotrexate-Induced

[+]

High-dose methotrexate during pregnancy is associated malformations. Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : Prescrire Int. 2010 Oct;19(109):212-3. PMID: 21180376

Article Published Date : Oct 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Birth Defects, Cardiomyopathy, Drug Toxicity: Methotrexate, Prenatal Chemical Exposures, Scoliosis

Problem Substances : Methotrexate

Adverse Pharmacological Actions : Teratogenic

[+]

Three cases of toxic skin eruptions associated with methotrexate have been reported.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Dermatol Online J. 2006;12(7):15. Epub 2006 Dec 10. PMID: 17459301

Article Published Date : Jan 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Drug Toxicity: Methotrexate

Problem Substances : Methotrexate

[+]

Acteoside alleviates intestinal mucositis in mice.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gastroenterol Res Pract. 2015 ;2015:327872. Epub 2015 Jan 5. PMID: 25628651

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Verbascoside

Diseases : Drug Toxicity: Methotrexate, Mucositis

Pharmacological Actions : Gastrointestinal Agents

Problem Substances : Methotrexate

[+]

Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-κB/NLRP3 pathway in Methotrexate-induced enteritis.Jul 31, 2022

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2022 Aug ;109:108824. Epub 2022 May 11. PMID: 35561481

Article Published Date : Jul 31, 2022

Study Type : Animal Study

Additional Links

Substances : Peony

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

Alpha lipoic acid ameliorates methotrexate induced oxidative damage of ovarian in rats.Mar 30, 2017

Click here to read the entire abstract

Pubmed Data : Gynecol Endocrinol. 2017 Mar 31:1-7. Epub 2017 Mar 31. PMID: 28361557

Article Published Date : Mar 30, 2017

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants

[+]

Alpha-lipoic acid may be suggested to be a prospective candidate to ameliorate Methotrexate induced oral mucositis.Feb 14, 2017

Click here to read the entire abstract

Pubmed Data : Life Sci. 2017 Feb 15 ;171:51-59. Epub 2017 Jan 3. PMID: 28062278

Article Published Date : Feb 14, 2017

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Drug Toxicity: Methotrexate, Oral Mucositis, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants

[+]

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2021 Apr 12:9603271211009964. Epub 2021 Apr 12. PMID: 33845614

Article Published Date : Apr 11, 2021

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

[+]

Apricot and beta-carotene have a potent protective effect against methotrexate-induced intestinal oxidative damage in rats.Sep 01, 2008

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2008 Sep;46(9):3015-22. Epub 2008 Jun 14. PMID: 18601970

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apricot, beta-Carotene

Diseases : Drug-Induced Toxicity: Methotrexate, Drug Toxicity: Methotrexate, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

[+]

Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Biotech Histochem. 2021 Dec 1:1-12. Epub 2021 Dec 1. PMID: 34850645

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants

Problem Substances : Methotrexate

[+]

Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.Jun 13, 2022

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2022 Jun 14:1-9. Epub 2022 Jun 14. PMID: 35698845

Article Published Date : Jun 13, 2022

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate

Pharmacological Actions : Hepatoprotective

Problem Substances : Methotrexate

[+]

Berberine or zinc protect against methotrexate-induced intestinal damage.Jun 23, 2021

Click here to read the entire abstract

Pubmed Data : Life Sci. 2021 Jun 24 ;281:119754. Epub 2021 Jun 24. PMID: 34174323

Article Published Date : Jun 23, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine, Zinc

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Gastroprotective

[+]

Cactus cladodes extract was effective in protecting the small intestine against methotrexate-induced damage.Aug 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer Res Ther. 2018 Sep ;14(Supplement):S779-S784. PMID: 30249903

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Drug Toxicity: Methotrexate, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Additional Keywords : Plant Extracts

[+]

Camel milk attenuates methotrexate-induced kidney injury.Apr 17, 2018

Click here to read the entire abstract

Pubmed Data : Food Funct. 2018 Apr 18. Epub 2018 Apr 18. PMID: 29667662

Article Published Date : Apr 17, 2018

Study Type : Animal Study

Additional Links

Substances : Camel Milk

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Renoprotective

[+]

Capsaicin ameliorate the nephrotoxicity induced by methotrexate.Oct 31, 2021

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2021 Nov ;34(6):2191-2195. PMID: 35034880

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Substances : Capsaicin

Diseases : Drug Toxicity: Methotrexate, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

[+]

Chicoric acid prevents methotrexate hepatotoxicity.May 31, 2020

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2020 Jun ;27(17):20725-20735. Epub 2020 Apr 3. PMID: 32246423

Article Published Date : May 31, 2020

Study Type : Animal Study

Additional Links

Substances : Chicoric Acid

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

[+]

Co-administration of geraniol with methotrexate may attenuate methotrexate-induced acute kidney injury.Oct 23, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Issues Mol Biol. 2021 Oct 24 ;43(3):1741-1755. Epub 2021 Oct 24. PMID: 34889889

Article Published Date : Oct 23, 2021

Study Type : Animal Study

Additional Links

Substances : Geraniol

Diseases : Drug Toxicity: Methotrexate, Kidney Damage

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

Problem Substances : Methotrexate

[+]

Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

Click here to read the entire abstract

Pubmed Data : Life Sci. 2022 Feb 7 ;295:120372. Epub 2022 Feb 7. PMID: 35143824

Article Published Date : Feb 06, 2022

Study Type : Animal Study

Additional Links

Substances : Neem

Diseases : Arthritis, Drug Toxicity: Methotrexate

Pharmacological Actions : Hepatoprotective, Renoprotective

[+]

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Med (Lausanne). 2022 ;9:866343. Epub 2022 Apr 14. PMID: 35492324

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Curcumin, Vitamin C

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2019 Aug ;71(4):746-752. Epub 2019 Apr 16. PMID: 31220735

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Methotrexate

[+]

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.Jun 01, 2008

Click here to read the entire abstract

Pubmed Data : J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Drug Toxicity: Methotrexate, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.Nov 15, 2015

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2015 Nov 16:1-8. Epub 2015 Nov 16. PMID: 26571019

Article Published Date : Nov 15, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Folic Acid

Diseases : Drug Toxicity: Methotrexate, Endothelial Dysfunction, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):119-21. PMID: 18227041

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Drug Toxicity: Methotrexate, Gastroenteritis, Intestinal Permeability

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Diallyl disulfide ameliorates methotrexate-induced nephropathy.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2021 06 ;45(6):e13765. Epub 2021 May 16. PMID: 33997994

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Methotrexate

[+]

Dietary cereals contribute to intestinal permeability in experimental enteropathy in rats.Sep 01, 1983

Click here to read the entire abstract

Pubmed Data : Gut. 1983 Sep ;24(9):825-30. PMID: 6411526

Article Published Date : Sep 01, 1983

Study Type : Animal Study

Additional Links

Diseases : Celiac Disease, Drug Toxicity: Methotrexate, Intestinal Permeability

Problem Substances : Gluten, Grains

[+]

Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:3281670. Epub 2017 Jul 27. PMID: 28819543

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Diosmin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Cardioprotective, Hepatoprotective, Renoprotective

[+]

Effects of rosmarinic acid on methotrexate-induced nephrotoxicity and hepatotoxicity.Apr 30, 2021

Click here to read the entire abstract

Pubmed Data : Indian J Nephrol. 2021 May-Jun;31(3):218-224. Epub 2021 Jan 27. PMID: 34376933

Article Published Date : Apr 30, 2021

Study Type : Animal Study

Additional Links

Substances : Rosmarinic acid

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Methotrexate

[+]

Ellagic acid and pumpkin seed oil protects against methotrexate-induced small intestine damage in rats.Nov 30, 2011

Click here to read the entire abstract

Pubmed Data : Indian J Biochem Biophys. 2011 Dec ;48(6):380-7. PMID: 22329239

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Pumpkin Seed Oil/Meal

Diseases : Drug Toxicity: Methotrexate, Gastrointestinal Hemorrhage

Pharmacological Actions : Gastroprotective

[+]

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292

Article Published Date : Dec 30, 2019

Study Type : Animal Study

Additional Links

Substances : Ferulic acid

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Methotrexate

[+]

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Food Funct. 2019 Aug 1 ;10(8):4593-4607. Epub 2019 Jul 10. PMID: 31289794

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Ferulic acid

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

[+]

Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity.Nov 02, 2021

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2021 Nov 3. Epub 2021 Nov 3. PMID: 34729716

Article Published Date : Nov 02, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginkgo biloba extract protects against methotrexate-induced hepatotoxicity.May 28, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 May 29 ;25(11). Epub 2020 May 29. PMID: 32486047

Article Published Date : May 28, 2020

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Glabridin plays dual action to augment the efficacy and attenuate the hepatotoxicity of methotrexate in arthritic rats.Sep 26, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ACS Omega. 2022 Sep 27 ;7(38):34341-34351. Epub 2022 Sep 14. PMID: 36188236

Article Published Date : Sep 26, 2022

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Licorice

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats.Apr 24, 2019

Click here to read the entire abstract

Pubmed Data : Nutrients. 2019 Apr 25 ;11(4). Epub 2019 Apr 25. PMID: 31027240

Article Published Date : Apr 24, 2019

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

Problem Substances : Methotrexate

[+]

Lactoferrin reduces methotrexate-induced small intestinal damage.Feb 29, 2004

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2004 Mar ;49(3):425-33. PMID: 15139492

Article Published Date : Feb 29, 2004

Study Type : Animal Study

Additional Links

Substances : Lactoferrin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Gastroprotective

[+]

Lutein prevented the methotrexate-induced oxidative lung damage.Sep 09, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Intern Med. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31495083

Article Published Date : Sep 09, 2019

Study Type : Animal Study

Additional Links

Substances : Lutein

Diseases : Drug Toxicity: Methotrexate, Lung Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Melatonin protects against methotrexate hepatotoxicity.Apr 30, 2023

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2023 May ;37(5):e23323. Epub 2023 Mar 8. PMID: 36890697

Article Published Date : Apr 30, 2023

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

[+]

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. May 26, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biosci Rep. 2020 May 27. Epub 2020 May 27. PMID: 32458964

Article Published Date : May 26, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Hepatoprotective

[+]

Nephroprotective effect of naringin in methotrexate induced renal toxicity.Sep 14, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Sep 15 ;143:112180. Epub 2021 Sep 15. PMID: 34536756

Article Published Date : Sep 14, 2021

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Methotrexate

[+]

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress.Jun 05, 2020

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2020 Jun 6 ;178:114083. Epub 2020 Jun 6. PMID: 32522593

Article Published Date : Jun 05, 2020

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Brain: Oxidative Stress, Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants, Neurogenesis, Neuroprotective Agents

[+]

Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats.Jun 01, 2006

Click here to read the entire abstract

Pubmed Data : Cancer Biol Ther. 2006 Jun;5(6):593-600. Epub 2006 Jun 5. PMID: 16627985

Article Published Date : Jun 01, 2006

Study Type : Animal Study

Additional Links

Substances : Streptococcus thermophilus

Diseases : Drug Toxicity: Methotrexate, Mucositis

[+]

Oxidative damage of Methotrexate in rat lung is partially reduced when combined with ALA.Mar 23, 2017

Click here to read the entire abstract

Pubmed Data : J Invest Surg. 2017 Mar 24:1-7. Epub 2017 Mar 24. PMID: 28340320

Article Published Date : Mar 23, 2017

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants

[+]

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Mediators Inflamm. 2020 ;2020:8641026. Epub 2020 Feb 10. PMID: 32104151

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Methotrexate

[+]

Paeonol protects against methotrexate hepatotoxicity.Oct 20, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmaceuticals (Basel). 2022 Oct 21 ;15(10). Epub 2022 Oct 21. PMID: 36297408

Article Published Date : Oct 20, 2022

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Paeonol protects against methotrexate-induced nephrotoxicity.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:774387. Epub 2022 Feb 4. PMID: 35185559

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective

[+]

Paullinia cupana seed extract ameliorated methotrexate-induced testicular dysfunction.Sep 26, 2022

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2022 Sep 27. Epub 2022 Sep 27. PMID: 36168017

Article Published Date : Sep 26, 2022

Study Type : Animal Study

Additional Links

Substances : Guarana

Diseases : Drug Toxicity: Methotrexate, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Pomegranate seed and peel methanolic extracts could protect against methotrexate induced oxidative stress and lipid profile changes in rats.May 31, 2017

Click here to read the entire abstract

Pubmed Data : Adv Pharm Bull. 2017 Jun ;7(2):269-274. Epub 2017 Jun 30. PMID: 28761829

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel, Pomegranate Seed

Diseases : Drug Toxicity: Methotrexate, Oxidative Stress

Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Hypolipidemic

Additional Keywords : Plant Extracts

[+]

Propolis is a potent antioxidant agent in preventing kidney injury caused by methotrexate.Mar 15, 2016

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2016 Mar 16:1-7. Epub 2016 Mar 16. PMID: 26981953

Article Published Date : Mar 15, 2016

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants

[+]

Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate.Mar 21, 2021

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2021 Mar 22:9603271211002891. Epub 2021 Mar 22. PMID: 33745333

Article Published Date : Mar 21, 2021

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants

Problem Substances : Methotrexate

[+]

Protective effects of crocin against methotrexate-induced hepatotoxicity.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cureus. 2023 Jan ;15(1):e34468. Epub 2023 Jan 31. PMID: 36874671

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hepatoprotective, Superoxide Dismutase Up-regulation

[+]

Protective effects of hesperidin against methotrexate-induced hepatotoxicity.Feb 25, 2020

Click here to read the entire abstract

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 26. Epub 2020 Feb 26. PMID: 32103295

Article Published Date : Feb 25, 2020

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Protective impacts of Moringa oleifera leaf extract against methotrexate-induced oxidative stress and apoptosis.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6738474. Epub 2020 May 29. PMID: 32565869

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Methotrexate

[+]

Puerarin improves methotrexate-induced renal damage.Apr 22, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Apr 23 ;103:915-922. Epub 2018 Apr 23. PMID: 29710508

Article Published Date : Apr 22, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Renoprotective

[+]

Punicalagin protects against the development of methotrexate-induced hepatotoxicity.Oct 14, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2022 Oct 15 ;23(20). Epub 2022 Oct 15. PMID: 36293191

Article Published Date : Oct 14, 2022

Study Type : Animal Study

Additional Links

Substances : Punicalagin

Diseases : Drug Toxicity: Methotrexate, Inflammation, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Quercetin ameliorates methotrexate-induced renal damage.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2015 ;37(9):1492-7. Epub 2015 Sep 3. PMID: 26338102

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Drug Toxicity: Methotrexate, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation, Renoprotective, Superoxide Dismutase Up-regulation

[+]

Quercetin reduced methotrexate induced oxidative stress through its antioxidant properties.Mar 21, 2016

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27005763

Article Published Date : Mar 21, 2016

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Reno-protective effect of mangiferin against methotrexate-induced kidney damage.Aug 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Saudi Pharm J. 2022 Sep ;30(9):1252-1261. Epub 2022 Jul 1. PMID: 36249937

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Resveratrol protects against methotrexate-induced liver injury in rats.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : J Pharm Pharm Sci. 2010;13(2):303-10. PMID: 20816014

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Stilbenes

[+]

Silibinin was demonstrated to protect the lung tissue against methotrexate induced pulmonary toxicity.Jul 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2015 Aug ;10(2):503-507. Epub 2015 Jun 3. PMID: 26622344

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Cytoprotective

[+]

The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction. May 29, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 May 30 ;128:110259. Epub 2020 May 30. PMID: 32485567

Article Published Date : May 29, 2020

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Problem Substances : Methotrexate

[+]

Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity.Dec 18, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2018 Dec 19 ;18(1):337. Epub 2018 Dec 19. PMID: 30567538

Article Published Date : Dec 18, 2018

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Drug Toxicity: Methotrexate, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Thymoquinone could confer intestinal protection against methotrexate induced mucositis.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2016 Jan ;12(Suppl 1):S76-81. PMID: 27041864

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.Jul 31, 2011

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2011 Aug ;30(8):897-903. Epub 2010 Sep 2. PMID: 20813795

Article Published Date : Jul 31, 2011

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Drug Toxicity: Methotrexate, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

[+]

Treatment with naringenin significantly reduced MTX induced pancytopenia, renal, and hepatic toxicity.Mar 20, 2021

Click here to read the entire abstract

Pubmed Data : Anticancer Agents Med Chem. 2021 Mar 21. Epub 2021 Mar 21. PMID: 34225639

Article Published Date : Mar 20, 2021

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

[+]

Treatment with oral pomegranate prevents mucosal injury and improves intestinal recovery following methotrexate injury in rats.Mar 12, 2018

Click here to read the entire abstract

Pubmed Data : J Am Coll Nutr. 2018 Mar 13:1-9. Epub 2018 Mar 13. PMID: 29533141

Article Published Date : Mar 12, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Chemoprotective Agents

[+]

Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327117745694. Epub 2017 Jan 1. PMID: 29216766

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Vanillin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Drug Toxicity: Methotrexate

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2008 Jul;53(7):1837-41. Epub 2008 Apr 22. PMID: 18427990

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Lactobacilius bulgaricus, Streptococcus thermophilus, Yoghurt

Diseases : Drug Toxicity: Methotrexate, Intestinal Permeability

[+]

Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.May 31, 2019

Click here to read the entire abstract

Pubmed Data : Inflamm Res. 2019 Jun ;68(6):511-523. Epub 2019 Apr 29. PMID: 31037316

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Chicoric Acid

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective

[+]

Curcumin may work synergistically with antifungal drugs to reverse multidrug resistance in Candida cells.Aug 01, 2009

Click here to read the entire abstract

Pubmed Data : Antimicrob Agents Chemother. 2009 Aug;53(8):3256-65. Epub 2009 May 26. PMID: 19470507

Article Published Date : Aug 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Candida Infection , Drug Toxicity: Methotrexate, Fungal Infections: Biofilm Formation/Resistance

Pharmacological Actions : Antifungal Agents, Enzyme Inhibitors

Additional Keywords : Drug Synergy

[+]

Diallyl disulfide potently alleviated methotrexate-induced hepatotoxicity.May 24, 2021

Click here to read the entire abstract

Pubmed Data : Curr Mol Pharmacol. 2021 May 25. Epub 2021 May 25. PMID: 34042041

Article Published Date : May 24, 2021

Study Type : In Vitro Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Methotrexate

[+]

Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.Jul 31, 2021

Click here to read the entire abstract

Pubmed Data : Life Sci. 2021 Aug 1 ;278:119583. Epub 2021 May 4. PMID: 33957170

Article Published Date : Jul 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Insights into the protective effects of thymoquinone against toxicities induced by chemotherapeutic agents.Dec 29, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Dec 30 ;27(1). Epub 2021 Dec 30. PMID: 35011457

Article Published Date : Dec 29, 2021

Study Type : Review

Additional Links

Substances : Thymoquinone

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Doxorubicin, Chemotherapy-Induced Toxicity: Tamoxifen, Drug Toxicity: Methotrexate

Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Hepatoprotective, Renoprotective

[+]

Lutein treatment attenuated the reduction in cell viability caused by H2O2. Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2017 ;45(6):1273-1291. PMID: 28893091

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lutein

Diseases : Drug Toxicity: Methotrexate, Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Autophagy Up-regulation

[+]

Lycopene improves methotrexate-induced functional alterations of the Madin-Darby kidney cells in a concentration-dependent manner.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2019 Aug 1. Epub 2019 Aug 1. PMID: 31369713

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lycopene

Diseases : Drug Toxicity: Methotrexate

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Methotrexate

Drug Toxicity: Methotrexate jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 75 Abstracts with Drug Toxicity: Methotrexate Research

Limited to Members Only

Currently Available Sorting Options

A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab has been reported.Nov 01, 2010

Folic acid has been observed to ameliorate methotrexate induced gynecomastia. Aug 01, 2010

High-dose methotrexate during pregnancy is associated malformations. Oct 01, 2010

Three cases of toxic skin eruptions associated with methotrexate have been reported.Jan 01, 2006

Acteoside alleviates intestinal mucositis in mice.Dec 31, 2014

Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-κB/NLRP3 pathway in Methotrexate-induced enteritis.Jul 31, 2022

Alpha lipoic acid ameliorates methotrexate induced oxidative damage of ovarian in rats.Mar 30, 2017

Alpha-lipoic acid may be suggested to be a prospective candidate to ameliorate Methotrexate induced oral mucositis.Feb 14, 2017

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Apricot and beta-carotene have a potent protective effect against methotrexate-induced intestinal oxidative damage in rats.Sep 01, 2008

Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate.Nov 30, 2021

Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.Jun 13, 2022

Berberine or zinc protect against methotrexate-induced intestinal damage.Jun 23, 2021

Cactus cladodes extract was effective in protecting the small intestine against methotrexate-induced damage.Aug 31, 2018

Camel milk attenuates methotrexate-induced kidney injury.Apr 17, 2018

Capsaicin ameliorate the nephrotoxicity induced by methotrexate.Oct 31, 2021

Chicoric acid prevents methotrexate hepatotoxicity.May 31, 2020

Co-administration of geraniol with methotrexate may attenuate methotrexate-induced acute kidney injury.Oct 23, 2021

Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.Jun 01, 2008

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.Nov 15, 2015

Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.Jan 01, 2008

Diallyl disulfide ameliorates methotrexate-induced nephropathy.Dec 31, 2020

Dietary cereals contribute to intestinal permeability in experimental enteropathy in rats.Sep 01, 1983

Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury.Dec 31, 2016

Effects of rosmarinic acid on methotrexate-induced nephrotoxicity and hepatotoxicity.Apr 30, 2021

Ellagic acid and pumpkin seed oil protects against methotrexate-induced small intestine damage in rats.Nov 30, 2011

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity.Nov 02, 2021

Ginkgo biloba extract protects against methotrexate-induced hepatotoxicity.May 28, 2020

Glabridin plays dual action to augment the efficacy and attenuate the hepatotoxicity of methotrexate in arthritic rats.Sep 26, 2022

Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats.Apr 24, 2019

Lactoferrin reduces methotrexate-induced small intestinal damage.Feb 29, 2004

Lutein prevented the methotrexate-induced oxidative lung damage.Sep 09, 2019

Melatonin protects against methotrexate hepatotoxicity.Apr 30, 2023

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. May 26, 2020

Nephroprotective effect of naringin in methotrexate induced renal toxicity.Sep 14, 2021

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress.Jun 05, 2020

Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats.Jun 01, 2006

Oxidative damage of Methotrexate in rat lung is partially reduced when combined with ALA.Mar 23, 2017

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Paeonol protects against methotrexate hepatotoxicity.Oct 20, 2022

Paeonol protects against methotrexate-induced nephrotoxicity.Dec 31, 2021

Paullinia cupana seed extract ameliorated methotrexate-induced testicular dysfunction.Sep 26, 2022

Pomegranate seed and peel methanolic extracts could protect against methotrexate induced oxidative stress and lipid profile changes in rats.May 31, 2017

Propolis is a potent antioxidant agent in preventing kidney injury caused by methotrexate.Mar 15, 2016

Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate.Mar 21, 2021

Protective effects of crocin against methotrexate-induced hepatotoxicity.Dec 31, 2022

Protective effects of hesperidin against methotrexate-induced hepatotoxicity.Feb 25, 2020

Protective impacts of Moringa oleifera leaf extract against methotrexate-induced oxidative stress and apoptosis.Dec 31, 2019

Puerarin improves methotrexate-induced renal damage.Apr 22, 2018

Punicalagin protects against the development of methotrexate-induced hepatotoxicity.Oct 14, 2022

Quercetin ameliorates methotrexate-induced renal damage.Dec 31, 2014

Quercetin reduced methotrexate induced oxidative stress through its antioxidant properties.Mar 21, 2016

Reno-protective effect of mangiferin against methotrexate-induced kidney damage.Aug 31, 2022

Resveratrol protects against methotrexate-induced liver injury in rats.Jan 01, 2010

Silibinin was demonstrated to protect the lung tissue against methotrexate induced pulmonary toxicity.Jul 31, 2015

The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction. May 29, 2020

Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity.Dec 18, 2018

Thymoquinone could confer intestinal protection against methotrexate induced mucositis.Dec 31, 2015

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.Jul 31, 2011

Treatment with naringenin significantly reduced MTX induced pancytopenia, renal, and hepatic toxicity.Mar 20, 2021

Treatment with oral pomegranate prevents mucosal injury and improves intestinal recovery following methotrexate injury in rats.Mar 12, 2018

Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys.Dec 31, 2016

Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.Jul 01, 2008

Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.May 31, 2019

Curcumin may work synergistically with antifungal drugs to reverse multidrug resistance in Candida cells.Aug 01, 2009

Diallyl disulfide potently alleviated methotrexate-induced hepatotoxicity.May 24, 2021

Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.Jul 31, 2021

Drug Toxicity: Methotrexate

View the Evidence:
75 Abstracts with Drug Toxicity: Methotrexate Research