Drug Toxicity: Methotrexate

Name	AC	CK
Curcumin	7	13
L-Carnitine	2	12
Flavonoids	5	9
Alpha-Lipoic Acid	4	8
Hesperidin	4	8
Thymoquinone	5	8
Apigenin	3	6
Apocynin	3	6
Astaxanthin	3	6
Paeonol	3	6
Citrus naringin	2	4
Crocin	2	4
Ferulic acid	2	4
Moringa oleifera	2	4
Peony	2	4
Quercetin	2	4
Silibinin	2	4
Streptococcus thermophilus	2	4
Vitamin C	2	4
Zinc	2	4
Chicoric Acid	2	3
Garlic	2	3
Hydrogen: Molecular	1	3
Lutein	2	3
Lycopene	2	3
Organosulfur Compounds	2	3
Allicin	1	2
Apricot	1	2
Bee Propolis	1	2
Berberine	1	2
Camel Milk	1	2
Capsaicin	1	2
Carnitine	1	2
Citral	1	2
Coenzyme Q10	1	2
Diosmin	1	2
EGCG (Epigallocatechin gallate)	1	2
Ellagic Acid	1	2
Folic Acid	1	2
Frankincense	1	2
Geraniol	1	2
Ginkgo biloba	1	2
Guarana	1	2
Hydroxytyrosol	1	2
Indole-3-Carbinol	1	2
Lactobacilius bulgaricus	1	2
Lactoferrin	1	2
Lemon Balm	1	2
Licorice	1	2
Mangiferin	1	2
Melatonin	1	2
Naringenin	1	2
Neem	1	2
Nobiletin	1	2
Pomegranate	1	2
Pomegranate Peel	1	2
Pomegranate Seed	1	2
Prickly Pear Cactus	1	2
Puerarin	1	2
Pumpkin Seed Oil/Meal	1	2
Punicalagin	1	2
Resveratrol	1	2
Rosmarinic acid	1	2
Silymarin	1	2
Vanillic Acid	1	2
Vanillin	1	2
Verbascoside	1	2
Vinpocetine	1	2
Vitamin E	1	2
Whey	1	2
Yoghurt	1	2
beta-Carotene	1	2
Cannabidiol	1	1
Isoflavones	1	1
Spirulina	1	1

Name	AC	CK
Methotrexate	21	42
Infliximab	1	3
Gluten	1	2
Grains	1	2

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L-carnitine as a novel approach for pain and inflammation relief in rheumatoid arthritis.Oct 31, 2025

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Inflammopharmacology. 2025 Nov ;33(11):6805-6811. Epub 2025 Oct 2. PMID: 41037123

Article Published Date : Oct 31, 2025

Study Type : Human Study

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Substances : L-Carnitine

Diseases : C-Reactive Protein, Drug Toxicity: Methotrexate, Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

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Pharmacological Actions : Immunomodulatory

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Three cases of toxic skin eruptions associated with methotrexate have been reported.Jan 01, 2006

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Pubmed Data : Dermatol Online J. 2006;12(7):15. Epub 2006 Dec 10. PMID: 17459301

Article Published Date : Jan 01, 2006

Study Type : Human: Case Report

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Diseases : Drug Toxicity: Methotrexate

Problem Substances : Methotrexate

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Acteoside alleviates intestinal mucositis in mice.Dec 31, 2014

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Pubmed Data : Gastroenterol Res Pract. 2015 ;2015:327872. Epub 2015 Jan 5. PMID: 25628651

Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate.Nov 30, 2021

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Pubmed Data : Biotech Histochem. 2021 Dec 1:1-12. Epub 2021 Dec 1. PMID: 34850645

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

Problem Substances : Methotrexate

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Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

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Pubmed Data : Life Sci. 2022 Feb 7 ;295:120372. Epub 2022 Feb 7. PMID: 35143824

Article Published Date : Feb 06, 2022

Study Type : Animal Study

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Substances : Neem

Diseases : Arthritis, Drug Toxicity: Methotrexate

Pharmacological Actions : Hepatoprotective, Renoprotective

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Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

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Pubmed Data : Front Immunol. 2024 ;15:1405084. Epub 2024 May 21. PMID: 38835771

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 14. Epub 2023 Jul 14. PMID: 37450013

Article Published Date : Jul 13, 2023

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Methotrexate

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Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292

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Pubmed Data : Biosci Rep. 2020 May 27. Epub 2020 May 27. PMID: 32458964

Article Published Date : May 26, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Hepatoprotective

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Nephroprotective effect of naringin in methotrexate induced renal toxicity.Sep 14, 2021

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Pubmed Data : Biomed Pharmacother. 2021 Sep 15 ;143:112180. Epub 2021 Sep 15. PMID: 34536756

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 26. Epub 2020 Feb 26. PMID: 32103295

Article Published Date : Feb 25, 2020

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Protective impacts of Moringa oleifera leaf extract against methotrexate-induced oxidative stress and apoptosis.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6738474. Epub 2020 May 29. PMID: 32565869

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The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction. May 29, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 May 30 ;128:110259. Epub 2020 May 30. PMID: 32485567

Article Published Date : May 29, 2020

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Problem Substances : Methotrexate

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Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity.Dec 18, 2018

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Pubmed Data : Dig Dis Sci. 2008 Jul;53(7):1837-41. Epub 2008 Apr 22. PMID: 18427990

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Lactobacilius bulgaricus, Streptococcus thermophilus, Yoghurt

Diseases : Drug Toxicity: Methotrexate, Intestinal Permeability

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Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity.Sep 28, 2023

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Pubmed Data : Curr Mol Pharmacol. 2021 May 25. Epub 2021 May 25. PMID: 34042041

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Pubmed Data : Am J Chin Med. 2017 ;45(6):1273-1291. PMID: 28893091

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lutein

Diseases : Drug Toxicity: Methotrexate, Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Autophagy Up-regulation

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Lycopene improves methotrexate-induced functional alterations of the Madin-Darby kidney cells in a concentration-dependent manner.Jul 31, 2019

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Pubmed Data : Can J Physiol Pharmacol. 2019 Aug 1. Epub 2019 Aug 1. PMID: 31369713

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View the Evidence: 106 Abstracts with Drug Toxicity: Methotrexate Research

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L-carnitine as a novel approach for pain and inflammation relief in rheumatoid arthritis.Oct 31, 2025

A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab has been reported.Nov 01, 2010

Folic acid has been observed to ameliorate methotrexate induced gynecomastia. Aug 01, 2010

High-dose methotrexate during pregnancy is associated malformations. Oct 01, 2010

Molecular hydrogen therapy in rheumatoid arthritis.Dec 31, 2024

Three cases of toxic skin eruptions associated with methotrexate have been reported.Jan 01, 2006

Acteoside alleviates intestinal mucositis in mice.Dec 31, 2014

Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-κB/NLRP3 pathway in Methotrexate-induced enteritis.Jul 31, 2022

Alpha lipoic acid ameliorates methotrexate induced oxidative damage of ovarian in rats.Mar 30, 2017

Alpha-lipoic acid may be suggested to be a prospective candidate to ameliorate Methotrexate induced oral mucositis.Feb 14, 2017

Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury.Jul 31, 2023

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Apigenin attenuates hippocampal microglial activation and restores cognitive function in methotrexate-treated rats.Jun 30, 2023

Apocynin abrogates methotrexate-induced nephrotoxicity.Mar 31, 2023

Apocynin attenuates methotrexate-induced mucositis.Feb 28, 2023

Apricot and beta-carotene have a potent protective effect against methotrexate-induced intestinal oxidative damage in rats.Sep 01, 2008

Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate.Nov 30, 2021

Astaxanthin prevents nephrotoxicity through Nrf2/ HO-1 pathway.Sep 07, 2023

Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.Jun 13, 2022

Berberine or zinc protect against methotrexate-induced intestinal damage.Jun 23, 2021

Boswellic acid and apigenin alleviate methotrexate-provoked renal and hippocampal alterations.May 06, 2024

Cactus cladodes extract was effective in protecting the small intestine against methotrexate-induced damage.Aug 31, 2018

Camel milk attenuates methotrexate-induced kidney injury.Apr 17, 2018

Capsaicin ameliorate the nephrotoxicity induced by methotrexate.Oct 31, 2021

Chicoric acid prevents methotrexate hepatotoxicity.May 31, 2020

Co-administration of geraniol with methotrexate may attenuate methotrexate-induced acute kidney injury.Oct 23, 2021

Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

Comparative study of the protective effects of citral, thymoquinone, and silymarin on methotrexate-induced cardiotoxicity.Sep 29, 2024

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Curcumin and vitamin C provided hepatoprotection against methotrexate-induced hepatotoxicity.Sep 30, 2024

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.Jun 01, 2008

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.Nov 15, 2015

Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.Jan 01, 2008

Cynaroside ameliorates methotrexate-induced enteritis.Dec 31, 2023

Diallyl disulfide ameliorates methotrexate-induced nephropathy.Dec 31, 2020

Dietary cereals contribute to intestinal permeability in experimental enteropathy in rats.Sep 01, 1983

Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury.Dec 31, 2016

Dose-dependent renoprotective effect of vanillic acid on methotrexate-induced nephrotoxicity.May 31, 2024

Effect of curcumin on methotrexate-induced ovarian damage and follicle reserve.Nov 30, 2025

Effects of rosmarinic acid on methotrexate-induced nephrotoxicity and hepatotoxicity.Apr 30, 2021

Ellagic acid and pumpkin seed oil protects against methotrexate-induced small intestine damage in rats.Nov 30, 2011

Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice.Feb 28, 2023

Examining hepatoprotective effects of astaxanthin against methotrexate-induced hepatotoxicity.Jul 13, 2023

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity.Nov 02, 2021

Ginkgo biloba extract protects against methotrexate-induced hepatotoxicity.May 28, 2020

Glabridin plays dual action to augment the efficacy and attenuate the hepatotoxicity of methotrexate in arthritic rats.Sep 26, 2022

Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats.Apr 24, 2019

Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate.Aug 16, 2023

Hydroxytyrosol alleviates methotrexate-induced pulmonary fibrosis in rats.Dec 31, 2023

L-carnitine and Zinc supplementation impedes intestinal damage in methotrexate-treated adjuvant-induced arthritis.Jun 30, 2023

L-carnitine attenuates methotrexate-induced cortical neurotoxicity via glial and apoptotic pathways.Oct 28, 2025

Lactoferrin reduces methotrexate-induced small intestinal damage.Feb 29, 2004

Lutein prevented the methotrexate-induced oxidative lung damage.Sep 09, 2019

Mechanisms of total glucosides of paeony in alleviating methotrexate-induced liver injury.Dec 31, 2024

Melatonin protects against methotrexate hepatotoxicity.Apr 30, 2023

Melissa Officinalis L. aqueous extract pretreatment decreases methotrexate-induced hepatotoxicity.Feb 28, 2023

Methotrexate-induced hepatotoxicity in rats and the therapeutic properties of vitamin E.Nov 30, 2023

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. May 26, 2020

Nephroprotective effect of naringin in methotrexate induced renal toxicity.Sep 14, 2021

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress.Jun 05, 2020

Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats.Mar 31, 2024

Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats.Jun 01, 2006

Oxidative damage of Methotrexate in rat lung is partially reduced when combined with ALA.Mar 23, 2017

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Paeonol protects against methotrexate hepatotoxicity.Oct 20, 2022

Paeonol protects against methotrexate-induced nephrotoxicity.Dec 31, 2021

Paullinia cupana seed extract ameliorated methotrexate-induced testicular dysfunction.Sep 26, 2022

Pomegranate seed and peel methanolic extracts could protect against methotrexate induced oxidative stress and lipid profile changes in rats.May 31, 2017

Propolis is a potent antioxidant agent in preventing kidney injury caused by methotrexate.Mar 15, 2016

Drug Toxicity: Methotrexate

View the Evidence:
106 Abstracts with Drug Toxicity: Methotrexate Research