Drug Toxicity: Methotrexate

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73 Substances Researched for Drug Toxicity: Methotrexate
NameACCKFocus
Curcumin59Locked
Flavonoids59Locked
Alpha-Lipoic Acid48Locked
Hesperidin48Locked
Thymoquinone58Locked
Apigenin36Locked
Apocynin36Locked
Astaxanthin36Locked
Paeonol36Locked
Citrus naringin24Locked
Crocin24Locked
Ferulic acid24Locked
Moringa oleifera24Locked
Quercetin24Locked
Silibinin24Locked
Streptococcus thermophilus24Locked
Zinc24Locked
Chicoric Acid23Locked
Garlic23Locked
Lutein23Locked
Lycopene23Locked
Organosulfur Compounds23Locked
Allicin12Locked
Apricot12Locked
Bee Propolis12Locked
Berberine12Locked
Camel Milk 12Locked
Capsaicin12Locked
Carnitine12Locked
Citral12Locked
Coenzyme Q1012Locked
Diosmin 12Locked
EGCG (Epigallocatechin gallate)12Locked
Ellagic Acid12Locked
Folic Acid 12Locked
Frankincense12Locked
Geraniol 12Locked
Ginkgo biloba12Locked
Guarana12Locked
Hydroxytyrosol12Locked
Indole-3-Carbinol12Locked
Lactobacilius bulgaricus12Locked
Lactoferrin12Locked
Lemon Balm12Locked
Licorice12Locked
Mangiferin12Locked
Melatonin12Locked
Naringenin 12Locked
Neem12Locked
Nobiletin 12Locked
Peony12Locked
Pomegranate12Locked
Pomegranate Peel12Locked
Pomegranate Seed12Locked
Prickly Pear Cactus12Locked
Puerarin12Locked
Pumpkin Seed Oil/Meal12Locked
Punicalagin12Locked
Resveratrol12Locked
Rosmarinic acid12Locked
Silymarin12Locked
Vanillic Acid12Locked
Vanillin12Locked
Verbascoside12Locked
Vinpocetine12Locked
Vitamin C12Locked
Vitamin E12Locked
Whey12Locked
Yoghurt12Locked
beta-Carotene12Locked
Cannabidiol11Locked
Isoflavones11Locked
Spirulina11Locked
4 Problem Substances Researched for Drug Toxicity: Methotrexate
NameACCKFocus
Methotrexate2142Locked
Infliximab13Locked
Gluten12Locked
Grains12Locked

View the Evidence:
100 Abstracts with Drug Toxicity: Methotrexate Research

[+]

A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab has been reported.Nov 01, 2010

Pubmed Data : Arthritis Rheum. 2010 Nov;62(11):3191-5. PMID: 20722036
Article Published Date : Nov 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug Toxicity: Methotrexate, Leukoencephalopathy
Problem Substances : Infliximab
[+]

Folic acid has been observed to ameliorate methotrexate induced gynecomastia. Aug 01, 2010

Pubmed Data : Rheumatol Int. 2010 Aug;30(10):1371-2. Epub 2009 Jul 12. PMID: 19597731
Article Published Date : Aug 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug Toxicity: Methotrexate, Gynecomastia: Methotrexate-Induced
[+]

High-dose methotrexate during pregnancy is associated malformations. Oct 01, 2010

Pubmed Data : Prescrire Int. 2010 Oct;19(109):212-3. PMID: 21180376
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Birth Defects, Cardiomyopathy, Drug Toxicity: Methotrexate, Prenatal Chemical Exposures, Scoliosis
Problem Substances : Methotrexate
Adverse Pharmacological Actions : Teratogenic
[+]

Three cases of toxic skin eruptions associated with methotrexate have been reported.Jan 01, 2006

Pubmed Data : Dermatol Online J. 2006;12(7):15. Epub 2006 Dec 10. PMID: 17459301
Article Published Date : Jan 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Drug Toxicity: Methotrexate
Problem Substances : Methotrexate
[+]

Acteoside alleviates intestinal mucositis in mice.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterol Res Pract. 2015 ;2015:327872. Epub 2015 Jan 5. PMID: 25628651
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Drug Toxicity: Methotrexate, Mucositis
Pharmacological Actions : Gastrointestinal Agents
Problem Substances : Methotrexate
[+]

Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-κB/NLRP3 pathway in Methotrexate-induced enteritis.Jul 31, 2022

Pubmed Data : Int Immunopharmacol. 2022 Aug ;109:108824. Epub 2022 May 11. PMID: 35561481
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

Alpha lipoic acid ameliorates methotrexate induced oxidative damage of ovarian in rats.Mar 30, 2017

Pubmed Data : Gynecol Endocrinol. 2017 Mar 31:1-7. Epub 2017 Mar 31. PMID: 28361557
Article Published Date : Mar 30, 2017
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants
[+]

Alpha-lipoic acid may be suggested to be a prospective candidate to ameliorate Methotrexate induced oral mucositis.Feb 14, 2017

Pubmed Data : Life Sci. 2017 Feb 15 ;171:51-59. Epub 2017 Jan 3. PMID: 28062278
Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Drug Toxicity: Methotrexate, Oral Mucositis, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury.Jul 31, 2023

Pubmed Data : Environ Sci Pollut Res Int. 2023 Aug ;30(38):88724-88733. Epub 2023 Jul 13. PMID: 37440131
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Allicin, Lycopene
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Pubmed Data : Hum Exp Toxicol. 2021 Apr 12:9603271211009964. Epub 2021 Apr 12. PMID: 33845614
Article Published Date : Apr 11, 2021
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Apigenin attenuates hippocampal microglial activation and restores cognitive function in methotrexate-treated rats.Jun 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neurobiol. 2023 Jul ;60(7):3770-3787. Epub 2023 Mar 21. PMID: 36943623
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Apocynin abrogates methotrexate-induced nephrotoxicity.Mar 31, 2023

Pubmed Data : Arch Pharm Res. 2023 Apr ;46(4):339-359. Epub 2023 Mar 13. PMID: 36913116
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Substances : Apocynin
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Renoprotective
[+]

Apocynin attenuates methotrexate-induced mucositis.Feb 28, 2023

Pubmed Data : Pak J Pharm Sci. 2023 Mar ;36(2):457-466. PMID: 37530153
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Apocynin
Diseases : Drug Toxicity: Methotrexate, Mucositis, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Apricot and beta-carotene have a potent protective effect against methotrexate-induced intestinal oxidative damage in rats.Sep 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Sep;46(9):3015-22. Epub 2008 Jun 14. PMID: 18601970
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Apricot, beta-Carotene
Diseases : Drug-Induced Toxicity: Methotrexate, Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate.Nov 30, 2021

Pubmed Data : Biotech Histochem. 2021 Dec 1:1-12. Epub 2021 Dec 1. PMID: 34850645
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
Problem Substances : Methotrexate
[+]

Astaxanthin prevents nephrotoxicity through Nrf2/ HO-1 pathway.Sep 07, 2023

Pubmed Data : Can J Physiol Pharmacol. 2023 Sep 8. Epub 2023 Sep 8. PMID: 37683291
Article Published Date : Sep 07, 2023
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.Jun 13, 2022

Pubmed Data : Drug Chem Toxicol. 2022 Jun 14:1-9. Epub 2022 Jun 14. PMID: 35698845
Article Published Date : Jun 13, 2022
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate
Pharmacological Actions : Hepatoprotective
Problem Substances : Methotrexate
[+]

Berberine or zinc protect against methotrexate-induced intestinal damage.Jun 23, 2021

Pubmed Data : Life Sci. 2021 Jun 24 ;281:119754. Epub 2021 Jun 24. PMID: 34174323
Article Published Date : Jun 23, 2021
Study Type : Animal Study
Additional Links
Substances : Berberine, Zinc
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Gastroprotective
[+]

Boswellic acid and apigenin alleviate methotrexate-provoked renal and hippocampal alterations.May 06, 2024

Pubmed Data : Int Immunopharmacol. 2024 May 7 ;134:112147. Epub 2024 May 7. PMID: 38718656
Article Published Date : May 06, 2024
Study Type : Animal Study
Additional Links
Substances : Apigenin, Frankincense
Diseases : Drug Toxicity: Methotrexate, Kidney Damage
Pharmacological Actions : Neuroprotective Agents, Renoprotective
[+]

Cactus cladodes extract was effective in protecting the small intestine against methotrexate-induced damage.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Res Ther. 2018 Sep ;14(Supplement):S779-S784. PMID: 30249903
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Prickly Pear Cactus
Diseases : Drug Toxicity: Methotrexate, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Gastroprotective
Additional Keywords : Plant Extracts
[+]

Camel milk attenuates methotrexate-induced kidney injury.Apr 17, 2018

Pubmed Data : Food Funct. 2018 Apr 18. Epub 2018 Apr 18. PMID: 29667662
Article Published Date : Apr 17, 2018
Study Type : Animal Study
Additional Links
Substances : Camel Milk
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Renoprotective
[+]

Capsaicin ameliorate the nephrotoxicity induced by methotrexate.Oct 31, 2021

Pubmed Data : Pak J Pharm Sci. 2021 Nov ;34(6):2191-2195. PMID: 35034880
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Capsaicin
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
[+]

Chicoric acid prevents methotrexate hepatotoxicity.May 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Jun ;27(17):20725-20735. Epub 2020 Apr 3. PMID: 32246423
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Chicoric Acid
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Co-administration of geraniol with methotrexate may attenuate methotrexate-induced acute kidney injury.Oct 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2021 Oct 24 ;43(3):1741-1755. Epub 2021 Oct 24. PMID: 34889889
Article Published Date : Oct 23, 2021
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Drug Toxicity: Methotrexate, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Methotrexate
[+]

Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

Pubmed Data : Life Sci. 2022 Feb 7 ;295:120372. Epub 2022 Feb 7. PMID: 35143824
Article Published Date : Feb 06, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Arthritis, Drug Toxicity: Methotrexate
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2022 ;9:866343. Epub 2022 Apr 14. PMID: 35492324
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumin, Vitamin C
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Natural Substance Synergy
[+]

Comparative study of the protective effects of citral, thymoquinone, and silymarin on methotrexate-induced cardiotoxicity.Sep 29, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2024 Sep 30 ;27(3):245-252. PMID: 39350925
Article Published Date : Sep 29, 2024
Study Type : Animal Study
Additional Links
Substances : Citral, Silymarin, Thymoquinone
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Cardioprotective
[+]

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Pubmed Data : Pharmacol Rep. 2019 Aug ;71(4):746-752. Epub 2019 Apr 16. PMID: 31220735
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Methotrexate
[+]

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.Jun 01, 2008

Pubmed Data : J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.Nov 15, 2015

Pubmed Data : Can J Physiol Pharmacol. 2015 Nov 16:1-8. Epub 2015 Nov 16. PMID: 26571019
Article Published Date : Nov 15, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin, Folic Acid
Diseases : Drug Toxicity: Methotrexate, Endothelial Dysfunction, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.Jan 01, 2008

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):119-21. PMID: 18227041
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Drug Toxicity: Methotrexate, Gastroenteritis, Intestinal Permeability
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Cynaroside ameliorates methotrexate-induced enteritis.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2024 ;15:1405084. Epub 2024 May 21. PMID: 38835771
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Drug Toxicity: Methotrexate, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 upregulation, Interleukin-1 beta downregulation
Problem Substances : Methotrexate
[+]

Diallyl disulfide ameliorates methotrexate-induced nephropathy.Dec 31, 2020

Pubmed Data : J Food Biochem. 2021 06 ;45(6):e13765. Epub 2021 May 16. PMID: 33997994
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Garlic, Organosulfur Compounds
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Methotrexate
[+]

Dietary cereals contribute to intestinal permeability in experimental enteropathy in rats.Sep 01, 1983

Pubmed Data : Gut. 1983 Sep ;24(9):825-30. PMID: 6411526
Article Published Date : Sep 01, 1983
Study Type : Animal Study
Additional Links
Diseases : Celiac Disease, Drug Toxicity: Methotrexate, Intestinal Permeability
Problem Substances : Gluten, Grains
[+]

Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:3281670. Epub 2017 Jul 27. PMID: 28819543
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Cardioprotective, Hepatoprotective, Renoprotective
[+]

Dose-dependent renoprotective effect of vanillic acid on methotrexate-induced nephrotoxicity.May 31, 2024

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun ;397(6):4195-4204. Epub 2023 Dec 2. PMID: 38041776
Article Published Date : May 31, 2024
Study Type : Animal Study
Additional Links
Substances : Vanillic Acid
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective
[+]

Effects of rosmarinic acid on methotrexate-induced nephrotoxicity and hepatotoxicity.Apr 30, 2021

Pubmed Data : Indian J Nephrol. 2021 May-Jun;31(3):218-224. Epub 2021 Jan 27. PMID: 34376933
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Rosmarinic acid
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Methotrexate
[+]

Ellagic acid and pumpkin seed oil protects against methotrexate-induced small intestine damage in rats.Nov 30, 2011

Pubmed Data : Indian J Biochem Biophys. 2011 Dec ;48(6):380-7. PMID: 22329239
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pumpkin Seed Oil/Meal
Diseases : Drug Toxicity: Methotrexate, Gastrointestinal Hemorrhage
Pharmacological Actions : Gastroprotective
[+]

Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2023 Mar ;27(6):2277-2287. PMID: 37013745
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation
[+]

Examining hepatoprotective effects of astaxanthin against methotrexate-induced hepatotoxicity.Jul 13, 2023

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 14. Epub 2023 Jul 14. PMID: 37450013
Article Published Date : Jul 13, 2023
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Methotrexate
[+]

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292
Article Published Date : Dec 30, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Methotrexate
[+]

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Pubmed Data : Food Funct. 2019 Aug 1 ;10(8):4593-4607. Epub 2019 Jul 10. PMID: 31289794
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity.Nov 02, 2021

Pubmed Data : Environ Sci Pollut Res Int. 2021 Nov 3. Epub 2021 Nov 3. PMID: 34729716
Article Published Date : Nov 02, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginkgo biloba extract protects against methotrexate-induced hepatotoxicity.May 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 May 29 ;25(11). Epub 2020 May 29. PMID: 32486047
Article Published Date : May 28, 2020
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Glabridin plays dual action to augment the efficacy and attenuate the hepatotoxicity of methotrexate in arthritic rats.Sep 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2022 Sep 27 ;7(38):34341-34351. Epub 2022 Sep 14. PMID: 36188236
Article Published Date : Sep 26, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Licorice
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats.Apr 24, 2019

Pubmed Data : Nutrients. 2019 Apr 25 ;11(4). Epub 2019 Apr 25. PMID: 31027240
Article Published Date : Apr 24, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Neurogenesis, Neuroprotective Agents
Problem Substances : Methotrexate
[+]

Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate.Aug 16, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2023 Aug 17 ;166:115329. Epub 2023 Aug 17. PMID: 37597319
Article Published Date : Aug 16, 2023
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Neuroprotective Agents
[+]

Hydroxytyrosol alleviates methotrexate-induced pulmonary fibrosis in rats.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2024 ;47(1):303-310. PMID: 38281774
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Hydroxytyrosol
Diseases : Drug Toxicity: Methotrexate, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-8 downregulation, Vascular Endothelial Growth Factor Inhibitors
[+]

L-carnitine and Zinc supplementation impedes intestinal damage in methotrexate-treated adjuvant-induced arthritis.Jun 30, 2023

Pubmed Data : J Trace Elem Med Biol. 2023 Jul ;78:127188. Epub 2023 Apr 28. PMID: 37163819
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Carnitine, Zinc
Diseases : Arthritis, Drug Toxicity: Methotrexate
Pharmacological Actions : Gastroprotective
[+]

Lactoferrin reduces methotrexate-induced small intestinal damage.Feb 29, 2004

Pubmed Data : Dig Dis Sci. 2004 Mar ;49(3):425-33. PMID: 15139492
Article Published Date : Feb 29, 2004
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Gastroprotective
[+]

Lutein prevented the methotrexate-induced oxidative lung damage.Sep 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Intern Med. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31495083
Article Published Date : Sep 09, 2019
Study Type : Animal Study
Additional Links
Substances : Lutein
Diseases : Drug Toxicity: Methotrexate, Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin protects against methotrexate hepatotoxicity.Apr 30, 2023

Pubmed Data : J Biochem Mol Toxicol. 2023 May ;37(5):e23323. Epub 2023 Mar 8. PMID: 36890697
Article Published Date : Apr 30, 2023
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
[+]

Melissa Officinalis L. aqueous extract pretreatment decreases methotrexate-induced hepatotoxicity.Feb 28, 2023

Pubmed Data : Ann Nucl Med. 2023 Mar ;37(3):166-175. Epub 2022 Dec 5. PMID: 36469234
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Lemon Balm
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
[+]

Methotrexate-induced hepatotoxicity in rats and the therapeutic properties of vitamin E.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Exp Hepatol. 2023 Dec ;9(4):359-367. Epub 2023 Oct 27. PMID: 38774203
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
[+]

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. May 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2020 May 27. Epub 2020 May 27. PMID: 32458964
Article Published Date : May 26, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Hepatoprotective
[+]

Nephroprotective effect of naringin in methotrexate induced renal toxicity.Sep 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Sep 15 ;143:112180. Epub 2021 Sep 15. PMID: 34536756
Article Published Date : Sep 14, 2021
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Problem Substances : Methotrexate
[+]

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress.Jun 05, 2020

Pubmed Data : Biochem Pharmacol. 2020 Jun 6 ;178:114083. Epub 2020 Jun 6. PMID: 32522593
Article Published Date : Jun 05, 2020
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Brain: Oxidative Stress, Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants, Neurogenesis, Neuroprotective Agents
[+]

Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats.Mar 31, 2024

Pubmed Data : Biotech Histochem. 2024 Apr ;99(3):134-146. Epub 2024 Apr 2. PMID: 38563051
Article Published Date : Mar 31, 2024
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats.Jun 01, 2006

Pubmed Data : Cancer Biol Ther. 2006 Jun;5(6):593-600. Epub 2006 Jun 5. PMID: 16627985
Article Published Date : Jun 01, 2006
Study Type : Animal Study
Additional Links
Substances : Streptococcus thermophilus
Diseases : Drug Toxicity: Methotrexate, Mucositis
[+]

Oxidative damage of Methotrexate in rat lung is partially reduced when combined with ALA.Mar 23, 2017

Pubmed Data : J Invest Surg. 2017 Mar 24:1-7. Epub 2017 Mar 24. PMID: 28340320
Article Published Date : Mar 23, 2017
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants
[+]

Paeonol has a protective effect against methotrexate-induced cardiac toxicity.Dec 31, 2019

Pubmed Data : Mediators Inflamm. 2020 ;2020:8641026. Epub 2020 Feb 10. PMID: 32104151
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Methotrexate
[+]

Paeonol protects against methotrexate hepatotoxicity.Oct 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Oct 21 ;15(10). Epub 2022 Oct 21. PMID: 36297408
Article Published Date : Oct 20, 2022
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Paeonol protects against methotrexate-induced nephrotoxicity.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:774387. Epub 2022 Feb 4. PMID: 35185559
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
[+]

Paullinia cupana seed extract ameliorated methotrexate-induced testicular dysfunction.Sep 26, 2022

Pubmed Data : Environ Sci Pollut Res Int. 2022 Sep 27. Epub 2022 Sep 27. PMID: 36168017
Article Published Date : Sep 26, 2022
Study Type : Animal Study
Additional Links
Substances : Guarana
Diseases : Drug Toxicity: Methotrexate, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Pomegranate seed and peel methanolic extracts could protect against methotrexate induced oxidative stress and lipid profile changes in rats.May 31, 2017

Pubmed Data : Adv Pharm Bull. 2017 Jun ;7(2):269-274. Epub 2017 Jun 30. PMID: 28761829
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Pomegranate Seed
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

Propolis is a potent antioxidant agent in preventing kidney injury caused by methotrexate.Mar 15, 2016

Pubmed Data : Ren Fail. 2016 Mar 16:1-7. Epub 2016 Mar 16. PMID: 26981953
Article Published Date : Mar 15, 2016
Study Type : Animal Study
Additional Links
Substances : Bee Propolis
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants
[+]

Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate.Mar 21, 2021

Pubmed Data : Hum Exp Toxicol. 2021 Mar 22:9603271211002891. Epub 2021 Mar 22. PMID: 33745333
Article Published Date : Mar 21, 2021
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants
Problem Substances : Methotrexate
[+]

Protective effects of apocynin on damaged testes of rats exposed to methotrexate.Aug 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Med Sci. 2020 Aug 26 ;50(5):1409-1420. Epub 2020 Aug 26. PMID: 32394677
Article Published Date : Aug 25, 2020
Study Type : Animal Study
Additional Links
Substances : Apocynin
Diseases : Drug Toxicity: Methotrexate, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation
[+]

Protective effects of crocin against methotrexate-induced hepatotoxicity.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Jan ;15(1):e34468. Epub 2023 Jan 31. PMID: 36874671
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hepatoprotective, Superoxide Dismutase Up-regulation
[+]

Protective effects of hesperidin against methotrexate-induced hepatotoxicity.Feb 25, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 26. Epub 2020 Feb 26. PMID: 32103295
Article Published Date : Feb 25, 2020
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective impacts of Moringa oleifera leaf extract against methotrexate-induced oxidative stress and apoptosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6738474. Epub 2020 May 29. PMID: 32565869
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Problem Substances : Methotrexate
[+]

Puerarin improves methotrexate-induced renal damage.Apr 22, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr 23 ;103:915-922. Epub 2018 Apr 23. PMID: 29710508
Article Published Date : Apr 22, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Renoprotective
[+]

Punicalagin protects against the development of methotrexate-induced hepatotoxicity.Oct 14, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Oct 15 ;23(20). Epub 2022 Oct 15. PMID: 36293191
Article Published Date : Oct 14, 2022
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Drug Toxicity: Methotrexate, Inflammation, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Quercetin ameliorates methotrexate-induced renal damage.Dec 31, 2014

Pubmed Data : Ren Fail. 2015 ;37(9):1492-7. Epub 2015 Sep 3. PMID: 26338102
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation, Renoprotective, Superoxide Dismutase Up-regulation
[+]

Quercetin reduced methotrexate induced oxidative stress through its antioxidant properties.Mar 21, 2016

Pubmed Data : Hum Exp Toxicol. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27005763
Article Published Date : Mar 21, 2016
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Reno-protective effect of mangiferin against methotrexate-induced kidney damage.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2022 Sep ;30(9):1252-1261. Epub 2022 Jul 1. PMID: 36249937
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Resveratrol protects against methotrexate-induced liver injury in rats.Jan 01, 2010

Pubmed Data : J Pharm Pharm Sci. 2010;13(2):303-10. PMID: 20816014
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Stilbenes
[+]

Silibinin was demonstrated to protect the lung tissue against methotrexate induced pulmonary toxicity.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Aug ;10(2):503-507. Epub 2015 Jun 3. PMID: 26622344
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Cytoprotective
[+]

Silibinin's effects against methotrexate-induced hepatotoxicity in adjuvant-induced arthritis rat model. Mar 27, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2024 Mar 28 ;17(4). Epub 2024 Mar 28. PMID: 38675395
Article Published Date : Mar 27, 2024
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Methotrexate
[+]

The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction. May 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 May 30 ;128:110259. Epub 2020 May 30. PMID: 32485567
Article Published Date : May 29, 2020
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Problem Substances : Methotrexate
[+]

Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity.Dec 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Dec 19 ;18(1):337. Epub 2018 Dec 19. PMID: 30567538
Article Published Date : Dec 18, 2018
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Drug Toxicity: Methotrexate, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

These findings suggest that taxifolin may be useful to treat methotrexate-associated oral mucositis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Appl Oral Sci. 2022 ;30:e20220115. Epub 2022 Sep 19. PMID: 36134855
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Drug Toxicity: Methotrexate, Mucositis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymoquinone could confer intestinal protection against methotrexate induced mucositis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 Jan ;12(Suppl 1):S76-81. PMID: 27041864
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.Jul 31, 2011

Pubmed Data : Hum Exp Toxicol. 2011 Aug ;30(8):897-903. Epub 2010 Sep 2. PMID: 20813795
Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Drug Toxicity: Methotrexate, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Antioxidants, Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone
[+]

Treatment with naringenin significantly reduced MTX induced pancytopenia, renal, and hepatic toxicity.Mar 20, 2021

Pubmed Data : Anticancer Agents Med Chem. 2021 Mar 21. Epub 2021 Mar 21. PMID: 34225639
Article Published Date : Mar 20, 2021
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Chemically-Induced Liver Damage, Drug Toxicity: Methotrexate, Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
[+]

Treatment with oral pomegranate prevents mucosal injury and improves intestinal recovery following methotrexate injury in rats.Mar 12, 2018

Pubmed Data : J Am Coll Nutr. 2018 Mar 13:1-9. Epub 2018 Mar 13. PMID: 29533141
Article Published Date : Mar 12, 2018
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Chemoprotective Agents
[+]

Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys.Dec 31, 2016

Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327117745694. Epub 2017 Jan 1. PMID: 29216766
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Vanillin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Drug Toxicity: Methotrexate
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Vinpocetine may represent a promising approach that can attenuate intestinal toxicity in patients receiving methotrexate.Aug 02, 2023

Pubmed Data : Immunopharmacol Immunotoxicol. 2023 Aug 3:1-9. Epub 2023 Aug 3. PMID: 37493389
Article Published Date : Aug 02, 2023
Study Type : Animal Study
Additional Links
Substances : Vinpocetine
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective
[+]

Whey protein concentrate ameliorates the methotrexate-induced liver and kidney damage.Mar 22, 2023

Pubmed Data : Br J Nutr. 2023 Mar 23:1-8. Epub 2023 Mar 23. PMID: 36950976
Article Published Date : Mar 22, 2023
Study Type : Animal Study
Additional Links
Substances : Whey
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.Jul 01, 2008

Pubmed Data : Dig Dis Sci. 2008 Jul;53(7):1837-41. Epub 2008 Apr 22. PMID: 18427990
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lactobacilius bulgaricus, Streptococcus thermophilus, Yoghurt
Diseases : Drug Toxicity: Methotrexate, Intestinal Permeability
[+]

Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity.Sep 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Sep 29. Epub 2023 Sep 29. PMID: 37773524
Article Published Date : Sep 28, 2023
Study Type : In Vitro Study
Additional Links
Substances : Spirulina, Thymoquinone
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.May 31, 2019

Pubmed Data : Inflamm Res. 2019 Jun ;68(6):511-523. Epub 2019 Apr 29. PMID: 31037316
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Chicoric Acid
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective
[+]

Curcumin may work synergistically with antifungal drugs to reverse multidrug resistance in Candida cells.Aug 01, 2009

Pubmed Data : Antimicrob Agents Chemother. 2009 Aug;53(8):3256-65. Epub 2009 May 26. PMID: 19470507
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Candida Infection , Drug Toxicity: Methotrexate, Fungal Infections: Biofilm Formation/Resistance
Pharmacological Actions : Antifungal Agents, Enzyme Inhibitors
Additional Keywords : Drug Synergy
[+]

Diallyl disulfide potently alleviated methotrexate-induced hepatotoxicity.May 24, 2021

Pubmed Data : Curr Mol Pharmacol. 2021 May 25. Epub 2021 May 25. PMID: 34042041
Article Published Date : May 24, 2021
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Organosulfur Compounds
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Methotrexate
[+]

Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.Jul 31, 2021

Pubmed Data : Life Sci. 2021 Aug 1 ;278:119583. Epub 2021 May 4. PMID: 33957170
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Isoflavones
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Insights into the protective effects of thymoquinone against toxicities induced by chemotherapeutic agents.Dec 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Dec 30 ;27(1). Epub 2021 Dec 30. PMID: 35011457
Article Published Date : Dec 29, 2021
Study Type : Review
Additional Links
Substances : Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Doxorubicin, Chemotherapy-Induced Toxicity: Tamoxifen, Drug Toxicity: Methotrexate
Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Hepatoprotective, Renoprotective
[+]

Lutein treatment attenuated the reduction in cell viability caused by H2O2. Dec 31, 2016

Pubmed Data : Am J Chin Med. 2017 ;45(6):1273-1291. PMID: 28893091
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lutein
Diseases : Drug Toxicity: Methotrexate, Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Autophagy Up-regulation
[+]

Lycopene improves methotrexate-induced functional alterations of the Madin-Darby kidney cells in a concentration-dependent manner.Jul 31, 2019

Pubmed Data : Can J Physiol Pharmacol. 2019 Aug 1. Epub 2019 Aug 1. PMID: 31369713
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Methotrexate
[+]

The effects of cannabidiol against Methotrexate-induced lung damage.Apr 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Pharmacol Toxicol. 2024 May ;134(5):695-703. Epub 2024 Feb 22. PMID: 38388876
Article Published Date : Apr 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Drug Toxicity: Methotrexate, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Unveiling the therapeutic potential of taxifolin in cancer.Aug 02, 2024

Pubmed Data : Phytomedicine. 2024 Aug 3 ;133:155934. Epub 2024 Aug 3. PMID: 39128306
Article Published Date : Aug 02, 2024
Study Type : Review
Additional Links
Substances : Flavonoids
Diseases : Cancers: All, Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Doxorubicin, Drug Toxicity: Methotrexate
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer, Hepatoprotective, Immunomodulatory, Renoprotective

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