Dry Eye Syndromes

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43 Substances Researched for Dry Eye Syndromes
NameACCKFocus
Omega-3 Fatty Acids1048Locked
Antioxidant formulas330Locked
Vitamin D330Locked
Sea buckthorn220Locked
Curcumin211Locked
Anthocyanins110Locked
Bilberry110Locked
Chinense Herbal Formula: Chi-Ju-Di-Huang-Wan110Locked
Flaxseed Oil110Locked
Ginseng (Korean)110Locked
Ginsenosides110Locked
Honey110Locked
Hyaluronic Acid110Locked
Iodine110Locked
Manuka Honey110Locked
Polyunsaturated Fatty Acids (PUFAs)110Locked
Royal Jelly110Locked
Tamarind110Locked
DHA (Docosahexaenoic Acid)24Locked
EGCG (Epigallocatechin gallate)23Locked
ALA (Alpha-Linolenic Acid)12Locked
Astaxanthin22Locked
Bifidobacterium Bifidum12Locked
Coconut12Locked
EPA (Eicosapentaenoic Acid)12Locked
Essential Fatty Acids22Locked
Evening Primrose Oil12Locked
Hu Zhang (Polygonum cuspidatum)12Locked
Lactobacillus plantarum12Locked
Nerve growth factor12Locked
Persimmon 12Locked
Sinomenine12Locked
Virgin Coconut Oil12Locked
Alpha-Lipoic Acid11Locked
Blueberry11Locked
Cannabidiol11Locked
Carnitine11Locked
Flavonoids11Locked
Lactoferrin11Locked
Maple11Locked
Omega-6 Fatty Acids11Locked
Pterostilbene11Locked
Pycnogenol (Pine Bark)11Locked
2 Problem Substances Researched for Dry Eye Syndromes
NameACCKFocus
Electronic Cigarettes110Locked
Bisphosphonates11Locked
6 Therapeutic Actions Researched for Dry Eye Syndromes
NameACCKFocus
Acupuncture440Locked
Electroacupuncture110Locked
Electrotherapy110Locked
Exercise110Locked
Massage/Therapeutic Touch110Locked
Yoga110Locked
2 Problematic Actions Researched for Dry Eye Syndromes
NameACCKFocus
Punctual plugs110Locked
Blue Light (400−495 nm)23Locked

View the Evidence:
73 Abstracts with Dry Eye Syndromes Research

[+]

A positive association was found between vitamin D deficiency and dry eye on comparing the above parameters.Jan 31, 2022

Pubmed Data : Indian J Ophthalmol. 2022 Feb ;70(2):500-504. PMID: 35086225
Article Published Date : Jan 31, 2022
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Dry Eye Syndromes, Vitamin D Deficiency
Additional Keywords : Increased Risk
[+]

Acupuncture and electrotherapy have therapeutic value in the treatment of dry eye syndrome.Jan 01, 2006

Pubmed Data : Am J Chin Med. 2006;34(2):197-206. PMID: 16552832
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Acupuncture, Electrotherapy
[+]

Acupuncture on the acupoints around the eyes has therapeutic value in the treatment of dry eye syndrome.Jun 01, 2010

Pubmed Data : Zhongguo Zhen Jiu. 2010 Jun;30(6):478-80. PMID: 20578386
Article Published Date : Jun 01, 2010
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Acupuncture
[+]

Acupuncture treatment can effectively relieve the symptoms of dry eye and increase watery secretion.Dec 01, 2010

Pubmed Data : J Altern Complement Med. 2010 Dec;16(12):1291-4. PMID: 21138389
Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Acupuncture
[+]

An artificial tear containing flaxseed oil could be useful for treating dry eye disease.Nov 13, 2019

Pubmed Data : Ocul Surf. 2019 Nov 14. Epub 2019 Nov 14. PMID: 31734510
Article Published Date : Nov 13, 2019
Study Type : Human Study
Additional Links
Substances : Flaxseed Oil
Diseases : Dry Eye Syndromes
[+]

Antioxidants improve tear stability, quantity and subjective clinical signs in dry eye syndrome. May 01, 2009

Pubmed Data : Eur J Ophthalmol. 2009 May-Jun;19(3):337-42. PMID: 19396775
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Antioxidant formulas
Diseases : Dry Eye Syndromes
[+]

Benefits and safety of astaxanthin in the treatment of mild-to-moderate dry eye disease.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2021 ;8:796951. Epub 2022 Jan 13. PMID: 35096941
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Astaxanthin
Diseases : Dry Eye Syndromes
Pharmacological Actions : Antioxidants
[+]

Bilberry extract can improve tear secretion and plasmatic antioxidant potential in subjects suffering from dry eye disease symptoms.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2017 05 ;21(10):2518-2525. PMID: 28617532
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Anthocyanins, Bilberry
Diseases : Dry Eye Syndromes, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Compared with artificial tears, electroacupuncture shows superior efficacy in improving tear film stability and symptoms of dry eyes.Oct 16, 2022

Pubmed Data : Acta Ophthalmol. 2022 Oct 17. Epub 2022 Oct 17. PMID: 36245315
Article Published Date : Oct 16, 2022
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Electroacupuncture
[+]

Curcumin has therapeutic value in the treatment of recurrent anterior uveitis of different etiologies. Jan 01, 2010

Pubmed Data : Clin Ophthalmol. 2010;4:1201-6. Epub 2010 Oct 21. PMID: 21060672
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Retinopathy, Dry Eye Syndromes, Eye Diseases, Glaucoma, Maculopathy, Maculopathy: Age-Related, Uveitis
[+]

Daily supplementation of Korean Red Ginseng for 8 weeks significantly improved the TBUT score and subjective dry eye symptoms, as compared to placebo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2015 Jan ;39(1):7-13. Epub 2014 Jul 23. PMID: 25535471
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Ginseng (Korean), Ginsenosides
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Significant Treatment Outcome , Supplementation
[+]

Dry eye and impaired tear function in patients with vitamin D deficiency may indicate a protective role of vitamin D in the development of dry eye.Aug 12, 2015

Pubmed Data : Int J Rheum Dis. 2015 Aug 13. Epub 2015 Aug 13. PMID: 26269110
Article Published Date : Aug 12, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Dry Eye Syndromes, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

Electroacupuncture can effectively treat dry eye syndrome by improving the symptoms, increasing tear secretion and extending tear film break-up time.Oct 03, 2019

Pubmed Data : Curr Eye Res. 2019 Oct 4:1-9. Epub 2019 Oct 4. PMID: 31557061
Article Published Date : Oct 03, 2019
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Electroacupuncture
[+]

Electroacupuncture inhibits the corneal ROS/TXNIP/NLRP3 signaling pathway in a rat model of dry eye syndrome.Sep 22, 2021

Pubmed Data : Acupunct Med. 2021 Sep 23:9645284211039235. Epub 2021 Sep 23. PMID: 34553633
Article Published Date : Sep 22, 2021
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Acupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

From Korea 150 patients with moderate to severe dry eye were randomly allocated into four weeks of acupuncture treatment or to the artificial tears group with significant improvement 8 weeks after treatment with acupuncture group.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(5):e36638. Epub 2012 May 17. PMID: 22615787
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Acupuncture
[+]

Gut dysbiosis is prevailing in Sjögren's syndrome and is related to dry eye severity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2020 ;15(2):e0229029. Epub 2020 Feb 14. PMID: 32059038
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes, Dysbiosis, Sjogren's Syndrome
Additional Keywords : Risk Factors
[+]

Higher dietary intake of omega-3 fatty acids is associated with decreased incidence of dry eye syndrome in women. Oct 01, 2005

Pubmed Data : Am J Clin Nutr. 2005 Oct;82(4):887-93. PMID: 16210721
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Dry Eye Syndromes
[+]

Impacts of air pollution on dry eye disease among residents in Hangzhou, China: A case-crossover study.Feb 28, 2019

Pubmed Data : Environ Pollut. 2019 Mar ;246:183-189. Epub 2018 Dec 4. PMID: 30543944
Article Published Date : Feb 28, 2019
Study Type : Human Study
Additional Links
Diseases : Air Pollution Linked Toxicity, Dry Eye Syndromes
Additional Keywords : Risk Factors
[+]

Iodine may have therapeutic value in the treatment of dry eye syndrome.May 23, 2010

Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2010 May 23. Epub 2010 May 23. PMID: 20496151
Article Published Date : May 23, 2010
Study Type : Human Study
Additional Links
Substances : Iodine
Diseases : Dry Eye Syndromes
[+]

Low serum 25(OH)D levels and inadequate sunlight exposure are associated with dry eye syndrome in Korean adults.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(1):e0147847. Epub 2016 Jan 25. PMID: 26807908
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Dry Eye Syndromes, Vitamin D Deficiency
Additional Keywords : Increased Risk
[+]

Optimel antibacterial honey treatments are effective as adjunctive therapies for meibomian gland dysfunction.Jun 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Exp Optom. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28585260
Article Published Date : Jun 05, 2017
Study Type : Human Study
Additional Links
Substances : Manuka Honey
Diseases : Dry Eye Syndromes
Additional Keywords : Dry Eye Syndromes, Manuka Honey
[+]

Oral antioxidant therapy improves marginal dry eye. Jul 01, 2001

Pubmed Data : Eur J Clin Nutr. 2001 Jul;55(7):589-97. PMID: 11464232
Article Published Date : Jul 01, 2001
Study Type : Human Study
Additional Links
Substances : Antioxidant formulas
Diseases : Dry Eye Syndromes
[+]

Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye.Aug 01, 2010

Pubmed Data : J Nutr. 2010 Aug;140(8):1462-8. Epub 2010 Jun 16. PMID: 20554904
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Substances : Antioxidant formulas, Omega-3 Fatty Acids, Sea buckthorn
Diseases : Dry Eye Syndromes
Pharmacological Actions : Antioxidants
[+]

Polyunsaturated fats alleviate symptoms related to dry eye syndrome. Oct 01, 2006

Pubmed Data : J Fr Ophtalmol. 2006 Oct;29(8):868-73. PMID: 17075501
Article Published Date : Oct 01, 2006
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Dry Eye Syndromes
[+]

Sea buckthorn spray on closed eyelids relieved the symptoms of dry eye.Nov 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cont Lens Anterior Eye. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30497904
Article Published Date : Nov 25, 2018
Study Type : Human Study
Additional Links
Substances : Sea buckthorn
Diseases : Dry Eye Syndromes
[+]

Sequential application of 0.3% and 0.15% hyaluronic acid improved symptoms/signs in moderate to severe dry eye disease patients.Dec 31, 2021

Pubmed Data : Jpn J Ophthalmol. 2022 Jan ;66(1):58-67. Epub 2021 Nov 29. PMID: 34843023
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Hyaluronic Acid
Diseases : Dry Eye Syndromes
[+]

The results suggest that an acute bout of exercise may attenuate symptoms of environmentally induced dry eye.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Rep. 2020 Jan ;8(2):e14262. PMID: 31997577
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Exercise
[+]

The traditional chinese formula Chi-Ju-Di-Huang-Wan appears to be an effective treatment of dry eye syndrome. Apr 01, 2005

Pubmed Data : Phytother Res. 2005 Apr;19(4):349-54. PMID: 16041734
Article Published Date : Apr 01, 2005
Study Type : Human Study
Additional Links
Substances : Chinense Herbal Formula: Chi-Ju-Di-Huang-Wan
Diseases : Dry Eye Syndromes
[+]

The use of LED-low-level light therapy for the treatment of dry eye and meibomian gland dysfunction appears to be safe and beneficial.Jan 03, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 03 4 ;12(1):3575. Epub 2022 Mar 4. PMID: 35246565
Article Published Date : Jan 03, 2022
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Laser Treatment: Low-Level
[+]

The use of punctual plugs may result in a number of significant adverse effects.Oct 01, 2006

Pubmed Data : Ophthalmology. 2006 Oct;113(10):1859.e1-6. Epub 2006 Aug 22. PMID: 16920195
Article Published Date : Oct 01, 2006
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes
Therapeutic Actions : Massage/Therapeutic Touch
Pharmacological Actions : Anti-Bacterial Agents
Anti Therapeutic Actions : Punctual plugs
[+]

These results suggest that royal jelly improves tear volume in patients with dry eye.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(1):e0169069. Epub 2017 Jan 6. PMID: 28060936
Article Published Date : Dec 31, 2016
Study Type : Animal Study, Human Study
Additional Links
Substances : Royal Jelly
Diseases : Dry Eye Syndromes
[+]

Topical appliation of antibacterial honey has beneficial effects on ocular flora and conjunctiva of dry eye subjects. Oct 01, 2006

Pubmed Data : Cornea. 2006 Oct;25(9):1012-9. PMID: 17133045
Article Published Date : Oct 01, 2006
Study Type : Human Study
Additional Links
Substances : Honey
Diseases : Dry Eye Syndromes
[+]

Topical tamarind seed extract and hyaluronic acid are therapeutic in treating dry eye syndrome. Mar 29, 2007

Pubmed Data : BMC Ophthalmol. 2007 Mar 29;7:5. PMID: 17394642
Article Published Date : Mar 29, 2007
Study Type : Human Study
Additional Links
Substances : Hyaluronic Acid, Tamarind
Diseases : Dry Eye Syndromes
[+]

Vapers showed moderate-to-severe symptomatic dry eye and poorer tear film quality compared with nonsmokers.Aug 31, 2019

Pubmed Data : Optom Vis Sci. 2019 Sep ;96(9):678-685. PMID: 31479023
Article Published Date : Aug 31, 2019
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes, Eye Damage
Additional Keywords : Increased Risk
Problem Substances : Electronic Cigarettes
[+]

Vitamin B1 and mecobalamin are potential treatment options for patients with dry eye disease.Sep 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Sep 11 ;14(18). Epub 2022 Sep 11. PMID: 36145126
Article Published Date : Sep 10, 2022
Study Type : Human Study
Additional Links
Substances : Thiamine (B-1) , Vitamin B-12
Diseases : Dry Eye Syndromes
Pharmacological Actions : Neuroprotective Agents
[+]

Vitamin D supplementation as an adjuvant to routine dry eye treatment improves ocular surface hemostasis parameters.Feb 20, 2022

Pubmed Data : Clin Exp Optom. 2022 Feb 21:1-6. Epub 2022 Feb 21. PMID: 35188874
Article Published Date : Feb 20, 2022
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Dry Eye Syndromes, Vitamin D Deficiency
[+]

Vitamin D supplementation improved the symptoms of dry eye syndrome.Oct 03, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Oct 4 ;6:33083. Epub 2016 Aug 4. PMID: 27698364
Article Published Date : Oct 03, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Dry Eye Syndromes, Vitamin D Deficiency
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Yoga practice appears to reduce visual discomfort in computer users.Jan 01, 2006

Pubmed Data : Head Face Med. 2006;2:46. Epub 2006 Dec 3. PMID: 17140457
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Computer display light exposure, Dry Eye Syndromes
Therapeutic Actions : Yoga
[+]

Dietary GLA, EPA and DHA have a preventive effect in a rat model of dry eye syndrome.Aug 01, 2009

Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2009 Aug;247(8):1039-50. Epub 2009 May 5. PMID: 19415319
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid)
Diseases : Dry Eye Syndromes
[+]

Acetylcholine and royal jelly fatty acid combinations as potential dry eye treatment.Jul 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Jul 24 ;13(8). Epub 2021 Jul 24. PMID: 34444696
Article Published Date : Jul 23, 2021
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Dry Eye Syndromes
[+]

Acupuncture alleviates corneal inflammation in New Zealand white rabbits with dry eye diseases.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:6613144. Epub 2022 Nov 14. PMID: 36419616
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Dry Eye Syndromes, Inflammation
Therapeutic Actions : Acupuncture
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID: 27336157
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Astragalus Ⅳ ameliorates the dry eye injury.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Histochem. 2021 Apr 1 ;65(2). Epub 2021 Apr 1. PMID: 33792228
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Dry Eye Syndromes
[+]

Isorhamnetin ameliorates dry eye disease via CFTR activation in mice.Apr 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Apr 12 ;22(8). Epub 2021 Apr 12. PMID: 33921231
Article Published Date : Apr 11, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lactobacillus plantarum and Bifidobacterium bifidum alleviate dry eye.Mar 20, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Funct. 2021 Mar 21 ;12(6):2489-2497. Epub 2021 Mar 3. PMID: 33656499
Article Published Date : Mar 20, 2021
Study Type : Animal Study
Additional Links
Substances : Bifidobacterium Bifidum, Lactobacillus plantarum
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Omega-3 fatty acids have therapeutic value in dry eye and corneal nerve regeneration after refractive surgery.Apr 01, 2010

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):319-25. Epub 2010 Mar 3. PMID: 20202804
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Omega-3 Fatty Acids
Diseases : Dry Eye Syndromes
Pharmacological Actions : Antiproliferative
[+]

Oral supplementation with evening primrose oil significantly improves symptoms of dry eye associated with contact lens use. Jun 01, 2008

Pubmed Data : Cont Lens Anterior Eye. 2008 Jun;31(3):141-6; quiz 170. Epub 2008 Mar 4. PMID: 18313350
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Evening Primrose Oil
Diseases : Dry Eye Syndromes
[+]

Overexposure to blue light with short wavelengths can induce oxidative damage and apoptosis to the cornea.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(8):e0161041. Epub 2016 Aug 12. PMID: 27517861
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Dry Eye Syndromes, Eye Damage, Inflammation
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Polygonum cuspidatum extract may have the potential to preserve eye health.Oct 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Oct 19 ;10(10). Epub 2018 Oct 19. PMID: 30347752
Article Published Date : Oct 18, 2018
Study Type : Animal Study
Additional Links
Substances : Hu Zhang (Polygonum cuspidatum)
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Prophylactic Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment.Mar 16, 2022

Pubmed Data : Environ Pollut. 2022 Mar 17:119126. Epub 2022 Mar 17. PMID: 35307497
Article Published Date : Mar 16, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Dry Eye Syndromes, Water Contamination
Additional Keywords : Microplastic
Problem Substances : Polystyrene nanoparticles
[+]

The effect of sinomenine eye drops on experimental dry eye.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cutan Ocul Toxicol. 2020 Dec ;39(4):389-395. Epub 2020 Nov 6. PMID: 33103493
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The leaves of Diospyros kaki exert beneficial effects on a benzalkonium chloride-induced murine dry eye model.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Vis. 2016 ;22:284-93. Epub 2016 Apr 2. PMID: 27110091
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Persimmon
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Apoptotic
Additional Keywords : Plant Extracts
[+]

Topical application of ALA omega-3 fatty acid significantly decreases dry eye signs and inflammatory changes. Feb 01, 2008

Pubmed Data : Arch Ophthalmol. 2008 Feb;126(2):219-25. PMID: 18268213
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : ALA (Alpha-Linolenic Acid), Omega-3 Fatty Acids
Diseases : Dry Eye Syndromes
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Topical application of Lycium barbarum polysaccharide could ameliorate dry eye.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2022 ;9:827594. Epub 2022 Mar 11. PMID: 35360713
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Goji
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Polysaccharides
[+]

Topical nerve growth factor treatment improves the condition of dogs affected by dry eye.Feb 01, 2005

Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2005 Feb;243(2):151-5. Epub 2005 Jan 14. PMID: 15650854
Article Published Date : Feb 01, 2005
Study Type : Animal Study
Additional Links
Substances : Nerve growth factor
Diseases : Dry Eye Syndromes
Pharmacological Actions : Neuritogenic
[+]

Virgin coconut oil acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:135987. Epub 2015 Feb 23. PMID: 25802534
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Coconut, Virgin Coconut Oil
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Flavonoid and cannabinoid impact on the ocular surface.Aug 09, 2020

Pubmed Data : Curr Opin Allergy Clin Immunol. 2020 Aug 10. Epub 2020 Aug 10. PMID: 32796166
Article Published Date : Aug 09, 2020
Study Type : Review
Additional Links
Substances : Cannabidiol, EGCG (Epigallocatechin gallate), Flavonoids, Pycnogenol (Pine Bark)
Diseases : Allergies, Dry Eye Syndromes, Eye Diseases
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents
[+]

A maple extract may be used to treat several ocular surface diseases where inflammation plays a key role.Jan 27, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 02 28 ;10(3). Epub 2018 Feb 28. PMID: 29495608
Article Published Date : Jan 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Maple
Diseases : Dry Eye Syndromes, Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Alpha-lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes.Jul 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Exp Pharmacol Physiol. 2020 Jul 4. Epub 2020 Jul 4. PMID: 32621549
Article Published Date : Jul 03, 2020
Study Type : Review
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Retinopathy, Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Alternative therapies for dry eye disease. Dec 31, 2020

Pubmed Data : Curr Opin Ophthalmol. 2021 07 1 ;32(4):348-361. PMID: 34010229
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Substances : Royal Jelly
Diseases : Dry Eye Syndromes
[+]

Bisphosphonates may induce conjunctival irritation.Jan 01, 2007

Pubmed Data : Bull Soc Belge Ophtalmol. 2007(304):155-78. PMID: 17718241
Article Published Date : Jan 01, 2007
Study Type : Commentary
Additional Links
Diseases : Conjunctival Diseases, Conjunctivitis, Dry Eye Syndromes
Problem Substances : Bisphosphonates
[+]

Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions.Jul 20, 2018

Pubmed Data : Free Radic Biol Med. 2018 Jul 21 ;126:27-40. Epub 2018 Jul 21. PMID: 30040995
Article Published Date : Jul 20, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Dry Eye Syndromes, Retinal Degeneration: Light-Induced
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Clinical applications of astaxanthin in the treatment of ocular diseases. Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2020 May 1 ;18(5). Epub 2020 May 1. PMID: 32370045
Article Published Date : Apr 30, 2020
Study Type : Review
Additional Links
Substances : Astaxanthin
Diseases : Cataract, Dry Eye Syndromes, Eye Diseases, Glaucoma
Pharmacological Actions : Antioxidants
[+]

Curcumin might have therapeutic potential for treating dry eye disease.Mar 01, 2010

Pubmed Data : Exp Eye Res. 2010 Mar;90(3):437-43. Epub 2009 Dec 23. PMID: 20026325
Article Published Date : Mar 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Dry Eye Syndromes
Pharmacological Actions : Antineoplastic Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Ophthalmol. 2017 Dec ;95(8):e677-e685. Epub 2017 Mar 30. PMID: 28371493
Article Published Date : Nov 30, 2017
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Dry Eye Syndromes
[+]

L-carnitine may be beneficial in age-related ocular pathologies. Jan 01, 2008

Pubmed Data : Drugs R D. 2008;9 Suppl 1:3-14. doi: 10.2165/0126839-200809001-00002. PMID: 19105587
Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Substances : Carnitine
Diseases : Dry Eye Syndromes, Eye Diseases, Glaucoma
[+]

Ocular application of oleuropein in dry eye treatment.Nov 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2021 Nov 12 ;14(11). Epub 2021 Nov 12. PMID: 34832933
Article Published Date : Nov 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Oleuropein
Diseases : Dry Eye Syndromes
Pharmacological Actions : Antioxidants
[+]

Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease.Dec 17, 2019

Pubmed Data : Cochrane Database Syst Rev. 2019 Dec 18 ;12:CD011016. Epub 2019 Dec 18. PMID: 31847055
Article Published Date : Dec 17, 2019
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids, Omega-6 Fatty Acids
Diseases : Dry Eye Syndromes
[+]

Omega-3 fatty acids may have therapeutic value in the treatment of dry eye syndrome.Feb 01, 2009

Pubmed Data : Neurosurg Focus. 2009 Feb;26(2):E8. PMID: 20105404
Article Published Date : Feb 01, 2009
Study Type : Review
Additional Links
Substances : Essential Fatty Acids, Omega-3 Fatty Acids
Diseases : Dry Eye Syndromes
Additional Keywords : Omega 3/6 Ratio
[+]

Pterostilbene protects human cornea from hyperosmolarity-induced inflammation and oxidative stress. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:19408. Epub 2016 Jan 14. PMID: 26762881
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Blueberry, Pterostilbene
Diseases : Dry Eye Syndromes, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Supplementation with omega-3 EFA may be beneficial in the treatment and prevention of Dry Eye Syndrome. Dec 21, 2009

Pubmed Data : Cont Lens Anterior Eye. 2009 Dec 21. Epub 2009 Dec 21. PMID: 20031476
Article Published Date : Dec 21, 2009
Study Type : Review
Additional Links
Substances : Essential Fatty Acids, Omega-3 Fatty Acids
Diseases : Dry Eye Syndromes
Additional Keywords : Risk Reduction
[+]

Therapeutic effects of lactoferrin in ocular diseases: From dry eye disease to Infections.Sep 11, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Sep 12 ;21(18). Epub 2020 Sep 12. PMID: 32932574
Article Published Date : Sep 11, 2020
Study Type : Review
Additional Links
Substances : Lactoferrin
Diseases : Coronavirus Infection, Dry Eye Syndromes
Pharmacological Actions : Antimicrobial, Antiviral Agents, Immunomodulatory
[+]

These results demonstrated the potential of high-affinity liposomal astaxanthin for the treatment of dry eye.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2019 Jan ;64(1):27-35. Epub 2018 Nov 30. PMID: 30705509
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Dry Eye Syndromes, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants

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