Epilepsy: Childhood

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6 Substances Researched for Epilepsy: Childhood

Name	AC	CK
Cannabidiol	6	53
Cannabis	2	20
Medium Chain Triglycerides	1	10
Nigella sativa (aka Black Seed)	1	10
Potassium	1	10
Delta-tetrahydrocannabinol (THC)	1	3

1 Therapeutic Actions Researched for Epilepsy: Childhood

Name	AC	CK	Focus
Dietary Modification: Low Carbohydrate/Ketogenic	7	70

Research Articles 14
Cumulative Knowledge Score 22
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Epilepsy: Childhood Research

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A ketogenic diet is an effective therapeutic modality for epilepsy associated with tuberous sclerosis in children. Oct 01, 2005

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Pubmed Data : Epilepsia. 2005 Oct;46(10):1684-6. PMID: 16190943

Article Published Date : Oct 01, 2005

Study Type : Human Study

Additional Links

Diseases : Epilepsy: Childhood, Tuberous Sclerosis

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

[+]

A Ketogenic diet is effective in refractory epilepsy of childhood.Dec 13, 1901

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Pubmed Data : Rev Neurol. 2001 Dec 1-15;33(11):1010-4. PMID: 11785025

Study Type : Human Study

Additional Links

Substances : Medium Chain Triglycerides

Diseases : Epilepsy: Childhood

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

[+]

Both a modified Atkins diet and the classic ketogenic diet could be used in the treatment of intractable epilepsy in children.Dec 09, 2015

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Pubmed Data : Epilepsia. 2015 Dec 10. Epub 2015 Dec 10. PMID: 26662710

Article Published Date : Dec 09, 2015

Study Type : Human Study

Additional Links

Diseases : Epilepsy: Childhood

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

[+]

Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.Dec 22, 2015

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Pubmed Data : Lancet Neurol. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26724101

Article Published Date : Dec 22, 2015

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy, Epilepsy: Childhood

Pharmacological Actions : Anticonvulsants

[+]

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

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Pubmed Data : Epilepsy Behav. 2013 Dec ;29(3):574-7. PMID: 24237632

Article Published Date : Nov 30, 2013

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy, Epilepsy: Childhood, Epileptic Seizures

Pharmacological Actions : Anticonvulsants

Additional Keywords : Treatment Resistant

[+]

Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.Jan 05, 2016

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Pubmed Data : Seizure. 2016 Jan 6 ;35:41-44. Epub 2016 Jan 6. PMID: 26800377

Article Published Date : Jan 05, 2016

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Epilepsy, Epilepsy: Childhood

Pharmacological Actions : Anticonvulsants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

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Pubmed Data : Epilepsy Behav. 2015 Apr 29. Epub 2015 Apr 29. PMID: 25935511

Article Published Date : Apr 28, 2015

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Epilepsy, Epilepsy: Childhood

Pharmacological Actions : Anticonvulsants

Additional Keywords : Plant Extracts

[+]

Potassium citrate reduces kidney-stone incidence in children treated with a ketogenic diet for intractable epilepsy. Aug 01, 2009

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Pubmed Data : Pediatrics. 2009 Aug;124(2):e300-4. Epub 2009 Jul 13. PMID: 19596731

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : Potassium

Diseases : Epilepsy: Childhood, Kidney Stones

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

[+]

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

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Pubmed Data : Pediatr Neurol. 2015 Nov ;53(5):422-6. Epub 2015 Aug 8. PMID: 26476148

Article Published Date : Oct 31, 2015

Study Type : Human Study

Additional Links

Diseases : Epilepsy: Childhood, Epileptic Seizures

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anticonvulsants

[+]

The ketogenic diet has significant therapy value in treating drug-resistant childhood epilepsy.Sep 01, 2010

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Pubmed Data : Seizure. 2010 Sep;19(7):404-8. Epub 2010 Jul 2. PMID: 20598586

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Diseases : Dravet syndrome, Epilepsy: Childhood, Infantile Spasms, Lennox-Gastaut Syndrome

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

[+]

The ketogenic diet is an effective therapy for children with therapy-resistant epilepsy.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Epilepsy Behav. 2015 Oct ;51:261-6. Epub 2015 Aug 24. PMID: 26301622

Article Published Date : Sep 30, 2015

Study Type : Human Study

Additional Links

Diseases : Epilepsy: Childhood

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

[+]

The results suggest that CBD may have beneficial effects on patient quality of life, distinct from its seizure-reducing effects.Jun 14, 2017

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Pubmed Data : Epilepsia. 2017 Jun 15. Epub 2017 Jun 15. PMID: 28617940

Article Published Date : Jun 14, 2017

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy: Childhood, Quality of Life: Poor

Pharmacological Actions : Anticonvulsants

[+]

The water extract of black cumin seed has significant anti-epileptic activity in children.Dec 01, 2007

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Pubmed Data : Med Sci Monit. 2007 Dec;13(12):CR555-9. PMID: 18049435

Article Published Date : Dec 01, 2007

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Epilepsy: Childhood

[+]

These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:359. Epub 2016 Aug 30. PMID: 27746737

Article Published Date : Dec 31, 2015

Study Type : Human: Case Report

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Epilepsy: Childhood

Pharmacological Actions : Anticonvulsants

Research Articles 14
Cumulative Knowledge Score 22
Overall Research Rating GOOD

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Focus Your Research

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View the Evidence: 14 Abstracts with Epilepsy: Childhood Research

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A ketogenic diet is an effective therapeutic modality for epilepsy associated with tuberous sclerosis in children. Oct 01, 2005

A Ketogenic diet is effective in refractory epilepsy of childhood.Dec 13, 1901

Both a modified Atkins diet and the classic ketogenic diet could be used in the treatment of intractable epilepsy in children.Dec 09, 2015

Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.Dec 22, 2015

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.Jan 05, 2016

Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

Potassium citrate reduces kidney-stone incidence in children treated with a ketogenic diet for intractable epilepsy. Aug 01, 2009

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

The ketogenic diet has significant therapy value in treating drug-resistant childhood epilepsy.Sep 01, 2010

The ketogenic diet is an effective therapy for children with therapy-resistant epilepsy.Sep 30, 2015

The results suggest that CBD may have beneficial effects on patient quality of life, distinct from its seizure-reducing effects.Jun 14, 2017

The water extract of black cumin seed has significant anti-epileptic activity in children.Dec 01, 2007

These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Dec 31, 2015

Print Options

Epilepsy: Childhood

View the Evidence:
14 Abstracts with Epilepsy: Childhood Research