Erectile Dysfunction

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46 Substances Researched for Erectile Dysfunction
NameACCKFocus
Arginine992Locked
Pycnogenol (Pine Bark)440Locked
Saffron440Locked
Tongkat Ali324Locked
Folic Acid 220Locked
Panax Ginseng211Locked
Polyphenols211Locked
Carnitine: propionyl-L-carnitine110Locked
Citrulline110Locked
Flavonoids110Locked
Maca110Locked
Niacin110Locked
Nuts110Locked
Pine Bark Extract110Locked
Saw Palmetto110Locked
Testosterone110Locked
Vitamin D110Locked
Yohimbe110Locked
Epimedium48Locked
Tribulus36Locked
Ginsenosides35Locked
Resveratrol35Locked
Almond24Locked
EGCG (Epigallocatechin gallate)24Locked
Moringa oleifera24Locked
Pumpkin24Locked
Berberine12Locked
Berberis amurensis12Locked
Carpolobia lutea12Locked
Citrus Peel 12Locked
Citrus naringin12Locked
Cornus officinalis12Locked
Fermented Foods and Beverages12Locked
Goji12Locked
Green Tea12Locked
Mucuna pruriens (aka Velvet Beans)12Locked
Naringenin 12Locked
Orange12Locked
P-Coumaric Acid12Locked
Pomegranate12Locked
Pumpkin Seeds12Locked
Raspberry12Locked
Rutin12Locked
Spirulina12Locked
Tangeretin 12Locked
Zinc12Locked
6 Problem Substances Researched for Erectile Dysfunction
NameACCKFocus
Statin Drugs764Locked
Cholesterol Lowering Drugs331Locked
Fenofibrates331Locked
Fluoxetine (trade name Prozac) 213Locked
Selective Serotonin Reuptake Inhibitors (SSRIs)213Locked
Bisphenol A 12Locked
7 Therapeutic Actions Researched for Erectile Dysfunction
NameACCKFocus
Dietary Modification: Mediterranean Diet110Locked
Electric Stimulation 110Locked
Exercise: Aerobic110Locked
Hyperbaric Treatment110Locked
Laughter/Humor110Locked
Magnet Therapy 110Locked
Exercise11Locked

View the Evidence:
99 Abstracts with Erectile Dysfunction Research

[+]

Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function.Sep 30, 2015

Pubmed Data : Complement Ther Med. 2015 Oct ;23(5):693-8. Epub 2015 Jul 31. PMID: 26365449
Article Published Date : Sep 30, 2015
Study Type : Meta Analysis, Review
Additional Links
Substances : Tongkat Ali
Diseases : Erectile Dysfunction
Additional Keywords : Plant Extracts
[+]

Lipid-lowering drugs contribute to erectile dysfunction. Feb 01, 2002

Pubmed Data : Fam Pract. 2002 Feb ;19(1):95-8. PMID: 11818357
Article Published Date : Feb 01, 2002
Study Type : Meta Analysis
Additional Links
Diseases : Erectile Dysfunction, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Fenofibrates, Statin Drugs
[+]

This systematic review and meta-analysis provide evidence on the effectiveness of arginine supplements for mild to moderate erectile dysfunction.Jan 31, 2019

Pubmed Data : J Sex Med. 2019 Feb ;16(2):223-234. PMID: 30770070
Article Published Date : Jan 31, 2019
Study Type : Meta Analysis, Review
Additional Links
Substances : Arginine
Diseases : Erectile Dysfunction
[+]

A combination of pine bark extract and L-arginine is effective for long-term improvement of erectile function. Feb 22, 2010

Pubmed Data : BJU Int. 2010 Feb 22. Epub 2010 Feb 22. PMID: 20184576
Article Published Date : Feb 22, 2010
Study Type : Human Study
Additional Links
Substances : Arginine, Pycnogenol (Pine Bark)
Diseases : Erectile Dysfunction
[+]

Administration of Pycnogenol leads in improvement of erectile function in patients with diabetes.Dec 31, 2018

Pubmed Data : Bratisl Lek Listy. 2019 ;120(12):941-944. PMID: 31855055
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : Polyphenols, Pycnogenol (Pine Bark)
Diseases : Diabetes Mellitus: Type 2, Erectile Dysfunction
Pharmacological Actions : Anticholesteremic Agents, Hypoglycemic Agents
[+]

Co-enzyme Q10 supplementation can be proposed as a potential candidate in patients with long-term hypertension and can play a role in erectile dysfunction.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2021 Sep ;13(9):e17937. Epub 2021 Sep 13. PMID: 34660127
Article Published Date : Aug 31, 2021
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Erectile Dysfunction
[+]

Compared to placebo, the prepared saffron gel could significantly improve erectile dysfunction in diabetic patientsMay 05, 2015

Pubmed Data : J Evid Based Complementary Altern Med. 2015 May 6. Epub 2015 May 6. PMID: 25948674
Article Published Date : May 05, 2015
Study Type : Human Study
Additional Links
Substances : Saffron
Diseases : Diabetic Complications, Erectile Dysfunction
Additional Keywords : Significant Treatment Outcome
[+]

Decreased folic acid might possibly be one of the novel risk factors for erectile dysfunction.Nov 02, 2020

Pubmed Data : Andrologia. 2020 Nov 3:e13890. Epub 2020 Nov 3. PMID: 33141950
Article Published Date : Nov 02, 2020
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Erectile Dysfunction, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Effect of nut consumption on erectile and sexual function in healthy males.Jun 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Jun 19 ;11(6). Epub 2019 Jun 19. PMID: 31248067
Article Published Date : Jun 18, 2019
Study Type : Human Study
Additional Links
Substances : Nuts
Diseases : Erectile Dysfunction
[+]

Erectile dysfunction may be a sentinel marker of endothelial dysfunction. Jul 01, 2009

Pubmed Data : Singapore Med J. 2009 Jul;50(7):698-701. PMID: 19644625
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Diseases : Endothelial Dysfunction, Erectile Dysfunction
Additional Keywords : Diseases that are Linked
[+]

Folic acid deficiency should be regarded as an independent risk factor for arteriogenic erectile dysfunction.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Endocrinol (Lausanne). 2023 ;14:1080188. Epub 2023 Jul 24. PMID: 37554765
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Erectile Dysfunction, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Folic acid may help with erectile dysfunction.Aug 24, 2015

Pubmed Data : Andrologia. 2015 Aug 25. Epub 2015 Aug 25. PMID: 26302884
Article Published Date : Aug 24, 2015
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Erectile Dysfunction, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Hyperbaric oxygen can induce angiogenesis and recover erectile function.May 17, 2018

Pubmed Data : Int J Impot Res. 2018 May 18. Epub 2018 May 18. PMID: 29773856
Article Published Date : May 17, 2018
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Angiogenesis Inducing Agents
[+]

L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with erectile dysfunction without any side effects.May 01, 2003

Pubmed Data : J Sex Marital Ther. 2003 May-Jun;29(3):207-13. PMID: 12851125
Article Published Date : May 01, 2003
Study Type : Human Study
Additional Links
Substances : Arginine, Flavonoids
Diseases : Erectile Dysfunction
Pharmacological Actions : Nitric Oxide Enhancer, Platelet Aggregation Inhibitors
[+]

Lichen simplex chronicus confers a greater risk in the development of erectile dysfunction.Dec 31, 2014

Pubmed Data : PLoS One. 2015 ;10(6):e0128869. Epub 2015 Jun 15. PMID: 26076496
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Lichenoid Dermatitis
Additional Keywords : Increased Risk
[+]

Lower dietary lycopene intake is positively associated with an increased risk of erectile dysfunction in US men.Apr 09, 2023

Pubmed Data : Andrology. 2023 Apr 10. Epub 2023 Apr 10. PMID: 37038051
Article Published Date : Apr 09, 2023
Study Type : Human Study
Additional Links
Substances : Lycopene
Diseases : Erectile Dysfunction
Additional Keywords : Risk Factors, Risk Reduction
[+]

Maca extract improves subjective perception of general and sexual well-being in adults patients with Erectile Dysfunction. Apr 01, 2009

Pubmed Data : Andrologia. 2009 Apr;41(2):95-9. PMID: 19260845
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Maca
Diseases : Erectile Dysfunction
[+]

Mediterranean diet improves erectile function in subjects with the metabolic syndrome.Jul 01, 2006

Pubmed Data : Int J Impot Res. 2006 Jul-Aug;18(4):405-10. Epub 2006 Jan 5. PMID: 16395320
Article Published Date : Jul 01, 2006
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Men treated with cholesterol-lowering drugs complain more frequently of erectile dysfunction.Apr 01, 1996

Pubmed Data : J Clin Pharm Ther. 1996 Apr ;21(2):89-94. PMID: 8809645
Article Published Date : Apr 01, 1996
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Fenofibrates, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Oral L-arginine in high doses seems to cause significant subjective improvement in sexual function in men with organic erectile dysfunction.Feb 01, 1999

Pubmed Data : BJU Int. 1999 Feb;83(3):269-73. PMID: 10233492
Article Published Date : Feb 01, 1999
Study Type : Human Study
Additional Links
Substances : Arginine
Diseases : Erectile Dysfunction
[+]

Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction.Jan 01, 2011

Pubmed Data : Urology. 2011 Jan;77(1):119-22. PMID: 21195829
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Erectile Dysfunction
[+]

Panax ginseng improves symptoms in men with erectile dysfunction. May 01, 2009

Pubmed Data : Asian J Androl. 2009 May;11(3):356-61. Epub 2009 Feb 23. PMID: 19234482
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Panax Ginseng
Diseases : Erectile Dysfunction
Additional Keywords : Plant Extracts
[+]

Pine Bark Extract, Saffron, Saw Palmetto for three months significantly improved sexual function, urinary symptoms.Aug 31, 2016

Pubmed Data : Minerva Urol Nefrol. 2016 Sep 1. Epub 2016 Aug 1. PMID: 27583656
Article Published Date : Aug 31, 2016
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract, Saffron, Saw Palmetto
Diseases : Erectile Dysfunction, Lower Urinary Tract Symptoms
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Propionyl-L-carnitine, L-arginine and niacin have value in erectile dysfunction. Oct 04, 2011

Pubmed Data : Andrologia. 2011 Oct 4. Epub 2011 Oct 4. PMID: 21966881
Article Published Date : Oct 04, 2011
Study Type : Human Study
Additional Links
Substances : Arginine, Carnitine: propionyl-L-carnitine, Niacin
Diseases : Erectile Dysfunction
[+]

Pycnogenol and L-arginine combination is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Ital Urol Androl. 2015 Sep ;87(3):190-3. Epub 2015 Sep 30. PMID: 26428638
Article Published Date : Aug 31, 2015
Study Type : Human Study
Additional Links
Substances : Arginine, Pycnogenol (Pine Bark)
Diseases : Erectile Dysfunction, Sperm Count: Low, Sperm Quality: Low
Pharmacological Actions : Antioxidants, Fertility Agents: Male
Additional Keywords : Plant Extracts
[+]

Pycnogenol® in combination with L-arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction.Jan 31, 2012

Pubmed Data : Phytother Res. 2012 Feb ;26(2):204-7. Epub 2011 May 27. PMID: 21618639
Article Published Date : Jan 31, 2012
Study Type : Human Study
Additional Links
Substances : Arginine, Pycnogenol (Pine Bark), Testosterone
Diseases : Erectile Dysfunction
[+]

Saffron has a positive effect on sexual function in patients with ED. Aug 01, 2009

Pubmed Data : Phytomedicine. 2009 Aug;16(8):690-3. Epub 2009 May 9. PMID: 19427775
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Saffron
Diseases : Erectile Dysfunction
[+]

Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction.Sep 30, 2012

Pubmed Data : Psychopharmacology (Berl). 2012 Oct ;223(4):381-8. Epub 2012 May 3. PMID: 22552758
Article Published Date : Sep 30, 2012
Study Type : Human Study
Additional Links
Substances : Saffron
Diseases : Erectile Dysfunction, Sexual Dysfunction: SSRI-induced
Additional Keywords : Plant Extracts
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Selective Serotonin Reuptake Inhibitors (SSRIs) are associated with sexual dysfunction in 95.6% of women and 97.9% men.Mar 01, 2006

Pubmed Data : J Affect Disord. 2006 Mar;91(1):27-32. Epub 2006 Jan 20. PMID: 16430968
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Sexual Dysfunction
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Serum total testosterone levels in patients with erectile dysfunction may be increased via aerobic exercise.Jan 25, 2018

Pubmed Data : World J Mens Health. 2018 Jan 26. Epub 2018 Jan 26. PMID: 29623694
Article Published Date : Jan 25, 2018
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Testosterone: Too Low
Therapeutic Actions : Exercise: Aerobic
[+]

Statin therapy contributes to low testosterone and hypogonadism in men with erectile dysfunctionApr 01, 2010

Pubmed Data : J Sex Med. 2010 Apr;7(4 Pt 1):1547-56. Epub 2010 Feb 5. PMID: 20141585
Article Published Date : Apr 01, 2010
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, High Cholesterol, Hypogonadism, Statin-Induced Pathologies, Testosterone: Too Low
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Statin treatment contributes to erectile dysfunction. Feb 01, 2006

Pubmed Data : Int J Clin Pract. 2006 Feb ;60(2):141-5. PMID: 16451283
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

Statin use has been associated with erectile dysfunction. Jan 01, 2009

Pubmed Data : Drug Saf. 2009;32(7):591-7. PMID: 19530745
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction
Problem Substances : Statin Drugs
[+]

The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.Feb 28, 2021

Pubmed Data : Maturitas. 2021 Mar ;145:78-85. Epub 2020 Dec 10. PMID: 33541567
Article Published Date : Feb 28, 2021
Study Type : Human Study
Additional Links
Substances : Tongkat Ali
Diseases : Aging, Androgen Deficiency, Erectile Dysfunction
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Transcranial magnetotherapy (TcMT) and electric stimulation (ES) improve erectile dysfunction in obese patients. Sep 01, 2009

Pubmed Data : Vopr Kurortol Fizioter Lech Fiz Kult. 2009 Sep-Oct(5):30-3. PMID: 19886019
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Low Testosterone
Therapeutic Actions : Electric Stimulation , Magnet Therapy
Pharmacological Actions : Secretagogue
[+]

Viewing humorous films in patients with atopic dermatitis leads to short-term improvement of erectile dysfunction. Sep 01, 2008

Pubmed Data : J Sex Med. 2008 Sep;5(9):2107-10. Epub 2008 Feb 4. PMID: 18266651
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Diseases : Atopic Dermatitis, Erectile Dysfunction, Low Testosterone
Therapeutic Actions : Laughter/Humor
[+]

Vitamin D deficiency is independently associated with greater prevalence of erectile dysfunction.Jul 28, 2016

Pubmed Data : Atherosclerosis. 2016 Jul 29 ;252:61-67. Epub 2016 Jul 29. PMID: 27505344
Article Published Date : Jul 28, 2016
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Vitamin D Deficiency
Additional Keywords : Increased Risk
[+]

Vitamin D treatment improves testosterone levels, metabolic syndrome and erectile function in middle-aged men.Jan 10, 2017

Pubmed Data : Aging Male. 2017 Jan 11:1-8. Epub 2017 Jan 11. PMID: 28074679
Article Published Date : Jan 10, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Erectile Dysfunction
[+]

Yohimbine (in combination with L-arginine glutamate) is effective in improving erectile function in patients with mild to moderate ED.Jun 01, 2002

Pubmed Data : Eur Urol. 2002 Jun;41(6):608-13; discussion 613. PMID: 12074777
Article Published Date : Jun 01, 2002
Study Type : Human Study
Additional Links
Substances : Arginine, Yohimbe
Diseases : Erectile Dysfunction
[+]

Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors has been reported. Jan 01, 2008

Pubmed Data : J Sex Med. 2008 Jan;5(1):227-33. PMID: 18173768
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Erectile Dysfunction
Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Statin-induced impotence has been reported. Feb 01, 1996

Pubmed Data : Ann Pharmacother. 1996 Feb ;30(2):192. PMID: 8835058
Article Published Date : Feb 01, 1996
Study Type : Human: Case Report
Additional Links
Diseases : Erectile Dysfunction, Impotence, Low Libido
Pharmacological Actions : Anticholesteremic Agents, Enzyme Inhibitors
Problem Substances : Statin Drugs
[+]

A methanol extract of C. lutea root enhances male sexual activity possibly by augmenting nitric oxide concentration.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Intercult Ethnopharmacol. 2015 Oct-Dec;4(4):302-7. Epub 2015 Nov 5. PMID: 26649235
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Carpolobia lutea
Diseases : Erectile Dysfunction
Pharmacological Actions : Aphrodisiac , Nitric Oxide Enhancer
Additional Keywords : Plant Extracts
[+]

Almond fruits could be beneficial in combating erectile dysfunction associated with diabetes.Nov 07, 2022

Pubmed Data : Andrologia. 2022 Nov 8:e14636. Epub 2022 Nov 8. PMID: 36349403
Article Published Date : Nov 07, 2022
Study Type : Animal Study
Additional Links
Substances : Almond
Diseases : Diabetes Mellitus: Type 2, Erectile Dysfunction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Almond-supplemented diet improves sexual functions beyond Phosphodiesterase-5 inhibition in diabetic male rats.Nov 30, 2019

Pubmed Data : Heliyon. 2019 Dec ;5(12):e03035. Epub 2019 Dec 18. PMID: 31890965
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Almond
Diseases : Diabetic Complications, Erectile Dysfunction
Additional Keywords : Risk Reduction
[+]

Beneficial effect of Berberis amurensis Rupr. on penile erection.Jan 14, 2018

Pubmed Data : Chin J Integr Med. 2018 Jan 15. Epub 2018 Jan 15. PMID: 29335865
Article Published Date : Jan 14, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberis amurensis
Diseases : Erectile Dysfunction
[+]

Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus.Oct 20, 2021

Pubmed Data : Andrology. 2021 Oct 21. Epub 2021 Oct 21. PMID: 34674380
Article Published Date : Oct 20, 2021
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic
[+]

Consumption of almond could prevent/reduce the erectile dysfunction in individual with diabetes.May 10, 2020

Pubmed Data : J Food Biochem. 2020 May 11:e13269. Epub 2020 May 11. PMID: 32394504
Article Published Date : May 10, 2020
Study Type : Animal Study
Additional Links
Substances : Almond
Diseases : Diabetes: Oxidative Stress, Erectile Dysfunction, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Depression induced by chronic stress leads to penile cavernosal dysfunction: protective effect of anti-TNF-α treatment.Jul 26, 2018

Pubmed Data : Can J Physiol Pharmacol. 2018 Jul 27:1-10. Epub 2018 Jul 27. PMID: 30052465
Article Published Date : Jul 26, 2018
Study Type : Animal Study
Additional Links
Diseases : Depression, Erectile Dysfunction
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Diets supplemented with raw and roasted pumpkin seeds improved some biochemical parameters associated with erectile function.Jan 31, 2021

Pubmed Data : J Food Biochem. 2021 Feb ;45(2):e13629. Epub 2021 Jan 27. PMID: 33502019
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Pumpkin
Diseases : Erectile Dysfunction
Pharmacological Actions : Antioxidants
[+]

Effects of cultured Cordycep militaris on sexual performance and erectile function in streptozotocin-induced diabetes.Dec 31, 2019

Pubmed Data : Biomed Res Int. 2020 ;2020:4198397. Epub 2020 Nov 13. PMID: 33274209
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation
[+]

EGCG consumption prevented diabetes-induced loss of cavernous smooth muscle.May 11, 2016

Pubmed Data : Int J Impot Res. 2016 May 12. Epub 2016 May 12. PMID: 27169491
Article Published Date : May 11, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Diabetes Mellitus: Type 1, Diabetic Complications, Erectile Dysfunction
[+]

Epigallocatechin-3-gallate ameliorates erectile function in aged rats.Apr 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian J Androl. 2016 Apr 15. Epub 2016 Apr 15. PMID: 27080477
Article Published Date : Apr 14, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Erectile Dysfunction
[+]

Epimedium improves erectile function of aged rats.Dec 03, 2007

Pubmed Data : J Ethnopharmacol. 2007 Dec 3;114(3):412-6. Epub 2007 Aug 19. PMID: 17890032
Article Published Date : Dec 03, 2007
Study Type : Animal Study
Additional Links
Substances : Epimedium
Diseases : Erectile Dysfunction
[+]

Epimedium's ability to elicit penile erection in the rat may be due to increased nitric oxide production.Feb 01, 2008

Pubmed Data : CNS Neurol Disord Drug Targets. 2008 Feb;7(1):20-7. PMID: 16527595
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : Epimedium
Diseases : Erectile Dysfunction
[+]

Epimedium's therapeutic effect in the treatment of erectile function may be due to its ability to relax the smooth muscle of the corpus cavernosum.Jul 01, 2006

Pubmed Data : Int J Impot Res. 2006 Jul-Aug;18(4):335-42. Epub 2006 Jan 5. PMID: 16395327
Article Published Date : Jul 01, 2006
Study Type : Animal Study
Additional Links
Substances : Epimedium
Diseases : Erectile Dysfunction
[+]

Erectile dysfunction attenuation by naringenin in streptozotocin-induced diabetic rats.Jun 30, 2019

Pubmed Data : J Food Biochem. 2019 Jul ;43(7):e12885. Epub 2019 May 7. PMID: 31353690
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Exploring the potentials of some compounds from Garcinia kola seeds towards identification of novel PDE-5 inhibitors in erectile dysfunction therapy.Jul 31, 2021

Pubmed Data : Andrologia. 2021 Aug ;53(7):e14092. Epub 2021 May 4. PMID: 33945159
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Garcinia kola
Diseases : Erectile Dysfunction
[+]

Fermentation filtrates of Korean black raspberry (R. coreanus) have positive effects on the function of the male reproductive system by triggering a penile erection, enhancing serum testosterone levels, and increasing epididymal sperm counts.Sep 01, 2008

Pubmed Data : J Med Food. 2008 Sep;11(3):474-8. PMID: 18800894
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Raspberry
Diseases : Erectile Dysfunction, Sperm Count: Low, Sperm Quality: Low, Testosterone: Too Low
[+]

Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Androl Urol. 2022 Jul ;11(7):982-995. PMID: 35958898
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Diabetic Complications, Erectile Dysfunction
Additional Keywords : Polysaccharides
[+]

Ginsenoside Rg1, a compound found within ginseng, improves male copulatory behavior in mice. Sep 14, 2009

Pubmed Data : J Sex Med. 2009 Sep 14. Epub 2009 Sep 14. PMID: 19751391
Article Published Date : Sep 14, 2009
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Erectile Dysfunction, Low Libido, Low Testosterone
Pharmacological Actions : Aphrodisiac , Nitric Oxide Enhancer, Secretagogue
[+]

Ginsenoside Rg3 improves erectile function in streptozotocin-induced diabetic rats.Feb 28, 2015

Pubmed Data : J Sex Med. 2015 Mar ;12(3):611-20. Epub 2014 Dec 1. PMID: 25442300
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation
[+]

Goji extracts may have a positive effect to improve erectile function in an old-aged rat model.Dec 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Mens Health. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28064475
Article Published Date : Dec 21, 2016
Study Type : Animal Study
Additional Links
Substances : Goji
Diseases : Erectile Dysfunction
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Grapefruit peel extract mitigates paroxetine-induced erectile dysfunction.Apr 22, 2022

Pubmed Data : J Food Biochem. 2022 Apr 23:e14193. Epub 2022 Apr 23. PMID: 35460094
Article Published Date : Apr 22, 2022
Study Type : Animal Study
Additional Links
Substances : Grapefruit peel extract
Diseases : Erectile Dysfunction
Pharmacological Actions : Antioxidants, Enzyme Inhibitors
[+]

Green tea may have a preventive and/or therapeutic role in erectile dysfunction. Dec 01, 2008

Pubmed Data : Age (Dordr). 2008 Dec;30(4):217-28. Epub 2008 Apr 18. PMID: 19424845
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Green Tea
Diseases : Erectile Dysfunction
[+]

Icariin improves erectile function in spontaneously hypertensive rats by up-regulating Nrf2.Jan 31, 2021

Pubmed Data : Zhonghua Nan Ke Xue. 2021 Feb ;27(2):106-113. PMID: 34914325
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Erectile Dysfunction, Hypertension
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Icariin inhibits the formation of mitochondria-associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation.Aug 31, 2022

Pubmed Data : Andrology. 2022 Sep ;10(6):1208-1216. Epub 2022 Jul 11. PMID: 35765205
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Erectile Dysfunction, Radiation
Pharmacological Actions : Radioprotective
[+]

Icariin modulates eNOS activity via effect on post-translational protein-protein interactions to improve erectile functio.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Andrology. 2021 01 ;9(1):342-351. Epub 2020 Aug 9. PMID: 33507631
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Erectile Dysfunction, Hypertension
Additional Keywords : Phytotherapy
[+]

Icarin, a compound found within epimedium (horny goat weed) has erectogenic properties. Feb 05, 2010

Pubmed Data : J Sex Med. 2010 Feb 5. Epub 2010 Feb 5. PMID: 20141584
Article Published Date : Feb 05, 2010
Study Type : Animal Study
Additional Links
Substances : Epimedium
Diseases : Erectile Dysfunction
[+]

L-arginine improves the erectile response of rats.Sep 01, 1997

Pubmed Data : J Urol. 1997 Sep;158(3 Pt 1):942-7. PMID: 9258123
Article Published Date : Sep 01, 1997
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Erectile Dysfunction
Pharmacological Actions : Nitric Oxide Enhancer
[+]

M. oleifera leaves could be used in the treatment and management of erectile dysfunction.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Res Int. 2015 ;2015:175950. Epub 2015 Oct 5. PMID: 26557995
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Erectile Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Moringa oleifera leaf and seed inclusive diets influenced the restoration of biochemicals associated with erectile dysfunction in the penile tissue of STZ-induced diabetes. Jun 14, 2020

Pubmed Data : J Food Biochem. 2020 Jun 15:e13323. Epub 2020 Jun 15. PMID: 32538504
Article Published Date : Jun 14, 2020
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetic Complications, Erectile Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation.May 15, 2020

Pubmed Data : Reprod Toxicol. 2020 May 16 ;95:123-136. Epub 2020 May 16. PMID: 32428650
Article Published Date : May 15, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Bisphenol Toxicity, Erectile Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Bisphenol A
[+]

P-coumaric acid is capable of causing inhibitory effects on the activities of enzymes, associated with oxidative stress-induced erectile dysfunction.Jun 30, 2019

Pubmed Data : Andrologia. 2019 Jul ;51(6):e13281. Epub 2019 Apr 14. PMID: 30983021
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Erectile Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants, Enzyme Inhibitors
[+]

Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway.Jun 08, 2022

Pubmed Data : Andrology. 2022 Jun 9. Epub 2022 Jun 9. PMID: 35678254
Article Published Date : Jun 08, 2022
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Resveratrol works synergistically with the drug vardenafil in a diabetic animal model of erectile dysfunction.Jan 26, 2011

Pubmed Data : J Sex Med. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21269399
Article Published Date : Jan 26, 2011
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Erectile Dysfunction
Pharmacological Actions : Nitric Oxide Enhancer
Additional Keywords : Drug: Vardenafil, Drug Synergy
[+]

Role of JAK2 in the pathogenesis of diabetic erectile dysfunction and an intervention with berberine.Sep 25, 2019

Pubmed Data : J Sex Med. 2019 Sep 26. Epub 2019 Sep 26. PMID: 31564534
Article Published Date : Sep 25, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Erectile Dysfunction
[+]

Supplementation with S. platensis thus emerges as a promising new therapeutic alternative for the treatment of erectile dysfunction as induced by obesity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:3293065. Epub 2020 Jun 30. PMID: 32685091
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Erectile Dysfunction, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Supplementation with Spirulina platensis prevents damage to rat erections in a model of erectile dysfunction.Jul 21, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2022 Jul 22 ;20(8). Epub 2022 Jul 22. PMID: 35892935
Article Published Date : Jul 21, 2022
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Erectile Dysfunction, Obesity
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Tangeretin ameliorates erectile and testicular dysfunction.May 28, 2020

Pubmed Data : Reprod Toxicol. 2020 May 29. Epub 2020 May 29. PMID: 32479886
Article Published Date : May 28, 2020
Study Type : Animal Study
Additional Links
Substances : Tangeretin
Diseases : Erectile Dysfunction, Hypertension
Pharmacological Actions : Antioxidants
[+]

The polar extract of M. pruriens seed can be used for erectile dysfunction therapy.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2017 Mar ;10(3):238-252. Epub 2017 Mar 7. PMID: 28442107
Article Published Date : Feb 28, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Mucuna pruriens (aka Velvet Beans)
Diseases : Diabetic Complications, Erectile Dysfunction
Additional Keywords : Plant Extracts
[+]

The potentials of the pumpkin seeds to manage erectile dysfunction was recommended.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2017 Dec ;12:5-11. Epub 2017 Aug 16. PMID: 28955786
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Erectile Dysfunction
Pharmacological Actions : Enzyme Inhibitors
[+]

These results highlight the success of antioxidant mechanism of pomegranate juice in erectile dysfunction with diabetes.Aug 31, 2016

Pubmed Data : Int J Impot Res. 2016 Sep 1. Epub 2016 Sep 1. PMID: 27581707
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Diabetic Complications, Erectile Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

This study brought to limelight the medicinal importance of fluted pumpkin seed in erectile functions.Sep 08, 2019

Pubmed Data : J Food Biochem. 2019 Sep 9:e13037. Epub 2019 Sep 9. PMID: 31502274
Article Published Date : Sep 08, 2019
Study Type : Animal Study
Additional Links
Substances : Pumpkin
Diseases : Erectile Dysfunction
[+]

This study showed some possible biochemical basis underlying the use of orange peels infusion in erectile dysfunction management.Jul 25, 2019

Pubmed Data : Andrologia. 2019 Jul 26:e13371. Epub 2019 Jul 26. PMID: 31347717
Article Published Date : Jul 25, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus Peel , Orange
Diseases : Erectile Dysfunction
[+]

Tongkat Ali (Euycoma longifolia) improved sexual performance and testosterone but not motivation in sluggish rats. Nov 12, 2009

Pubmed Data : J Ethnopharmacol. 2009 Nov 12;126(2):308-13. Epub 2009 Aug 22. PMID: 19703544
Article Published Date : Nov 12, 2009
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Erectile Dysfunction, Low Testosterone, Sexual Dysfunction
Pharmacological Actions : Secretagogue
[+]

Tongkat Ali improves sexual arousal in sexually sluggish old male rats. Jan 01, 2004

Pubmed Data : J Basic Clin Physiol Pharmacol. 2004;15(3-4):303-9. PMID: 15803965
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Erectile Dysfunction, Low Libido
Pharmacological Actions : Aphrodisiac
[+]

Trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.Jan 01, 2008

Pubmed Data : Arch Pharm Res. 2008 Jan;31(1):83-7. PMID: 18277612
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Erectile Dysfunction, Sperm Quality: Low, Testosterone: Too Low
Additional Keywords : Stilbenes
[+]

Treatment with rutin improved sexual functionality and also protects against diabetic-induced testicular damage.Oct 25, 2016

Pubmed Data : Andrologia. 2016 Oct 26. Epub 2016 Oct 26. PMID: 27785836
Article Published Date : Oct 25, 2016
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Cytoprotective
[+]

Tribulus has a proerectile activity. Jan 01, 2000

Pubmed Data : Ann Acad Med Singapore. 2000 Jan;29(1):22-6. PMID: 10748960
Article Published Date : Jan 01, 2000
Study Type : Animal Study
Additional Links
Substances : Tribulus
Diseases : Erectile Dysfunction
Additional Keywords : Plant Extracts
[+]

Tribulus terrestris and Cornus officinalis may have value in treating penile erection dysfunction.Sep 30, 2012

Pubmed Data : J Sex Med. 2012 Oct ;9(10):2544-51. Epub 2012 Aug 20. PMID: 22906304
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Cornus officinalis, Tribulus
Diseases : Erectile Dysfunction
[+]

Tribulus terrestris may be useful in treating mild to moderate cases of erectile dysfunction. Jan 01, 2008

Pubmed Data : Phytomedicine. 2008 Jan;15(1-2):44-54. PMID: 18068966
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Tribulus
Diseases : Erectile Dysfunction, Low DHEA, Low Testosterone
[+]

Zinc improves testosterone and prolactin levels and erectile function in male rats. Jul 01, 2009

Pubmed Data : J Hum Reprod Sci. 2009 Jul;2(2):57-61. PMID: 19881149
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Zinc
Diseases : Erectile Dysfunction, Low Testosterone, Prolactin: Low, Sexual Dysfunction
[+]

Exercise has a beneficial effect on erectile function.Mar 01, 2009

Pubmed Data : J Sex Med. 2009 Mar;6 Suppl 3:254-61. PMID: 19170860
Article Published Date : Mar 01, 2009
Study Type : Commentary
Additional Links
Diseases : Erectile Dysfunction
Therapeutic Actions : Exercise
[+]

Lipid-lowering drugs may contribute to erectile dysfunction.Oct 01, 2002

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Fam Pract. 2002 Oct ;19(5):567. PMID: 12356716
Article Published Date : Oct 01, 2002
Study Type : Review
Additional Links
Diseases : Erectile Dysfunction, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Fenofibrates, Statin Drugs
[+]

Panax Ginseng has potential in the treatment of Erective Dysfunction.Oct 01, 2008

Pubmed Data : Br J Clin Pharmacol. 2008 Oct;66(4):444-50. Epub 2008 Jun 9. PMID: 18754850
Article Published Date : Oct 01, 2008
Study Type : Review
Additional Links
Substances : Panax Ginseng
Diseases : Erectile Dysfunction
[+]

Resveratrol protect against hypercholesterolemia-induced erectile dysfunction and endothelial dysfunction. Aug 01, 2008

Pubmed Data : Indian J Exp Biol. 2008 Aug;46(8):583-90. PMID: 20596084
Article Published Date : Aug 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Endothelial Dysfunction, Erectile Dysfunction, High Cholesterol
Pharmacological Actions : Vasoprotective
Additional Keywords : Stilbenes
[+]

The polyphenols identified in this review exert beneficial roles in the management of erectile dysfunction.Mar 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:644-652. Epub 2017 Jan 29. PMID: 28142121
Article Published Date : Mar 31, 2017
Study Type : Review
Additional Links
Substances : Polyphenols
Diseases : Erectile Dysfunction
[+]

These observations suggest a role for steamed ginseng containing two pairs of geometric isomers in the treatment of erectile dysfunction.Jan 02, 2018

Pubmed Data : Am J Chin Med. 2018 Jan 3:1-19. Epub 2018 Jan 3. PMID: 29298510
Article Published Date : Jan 02, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Erectile Dysfunction
[+]

Korean ginseng has therapeutic value in the treatment of erectile dysfunction.Sep 01, 1995

Pubmed Data : Int J Impot Res. 1995 Sep;7(3):181-6. PMID: 8750052
Article Published Date : Sep 01, 1995
Additional Links
Diseases : Erectile Dysfunction

Copyright: blueringmedia / 123RF Stock Photo

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