Estrogen Dominance

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40 Substances Researched for Estrogen Dominance
NameACCKFocus
Soy220Locked
Seaweed212Locked
Fiber110Locked
Sesamin110Locked
phytoestrogens110Locked
Isoflavones45Locked
Lignans34Locked
Berries: All23Locked
Ellagic Acid23Locked
Genistein33Locked
Resveratrol33Locked
Blueberry12Locked
Curcumin22Locked
Enterodiol22Locked
Flavonoids22Locked
Kelp12Locked
Raspberry12Locked
Rosemary12Locked
Rye12Locked
Seaweed: Brown 12Locked
Biochanin A11Locked
Blackberry11Locked
Brussel sprouts11Locked
Cabbage11Locked
Coffee11Locked
Daidzein11Locked
Damiana11Locked
Enterolactone11Locked
Euonymus alatus (Burning Bush)11Locked
Indole-3-Carbinol11Locked
Ipriflavone11Locked
Licorice11Locked
Mangosteen11Locked
Melatonin11Locked
NAC (N-acetyl-L-cysteine)11Locked
Pomegranate11Locked
Sculletaria barbata11Locked
Stilbenes11Locked
Vitamin D11Locked
Yerba Mate11Locked
19 Problem Substances Researched for Estrogen Dominance
NameACCKFocus
17beta-estradiol211Locked
Triclosan12Locked
Aluminum11Locked
Antimony11Locked
Arsenite11Locked
Barium11Locked
Cadmium11Locked
Chromium Chloride11Locked
Cobalt11Locked
Industrial Copper (inorganic)11Locked
Lead11Locked
Mercury11Locked
Mycoestrogens11Locked
Polychlorinated biphenyls (PCBs)11Locked
Selenite11Locked
Tamoxifen11Locked
Tin11Locked
Vanadate11Locked
Zearalenone (ZEA)11Locked
2 Therapeutic Actions Researched for Estrogen Dominance
NameACCKFocus
Dietary Modification: Low Fat Diet110Locked
Placebo Effect110Locked

View the Evidence:
39 Abstracts with Estrogen Dominance Research

[+]

A very low fat, high fiber diet in healthy premenopausal women can reduce estradiol and estrone levels without affecting ovulation, thereby providing a rationale for the prevention of breast cancer through a very low fat, high fiber diet.Dec 15, 1995

Pubmed Data : Cancer. 1995 Dec 15;76(12):2491-6. PMID: 8625075
Article Published Date : Dec 15, 1995
Study Type : Human Study
Additional Links
Substances : Fiber
Diseases : Breast Cancer: Prevention, Estrogen Dominance
Therapeutic Actions : Dietary Modification: Low Fat Diet
Pharmacological Actions : Chemopreventive
[+]

Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users.Sep 01, 2009

Pubmed Data : Breast Cancer Res Treat. 2009 Sep;117(1):111-9. Epub 2008 Oct 18. PMID: 18931907
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : phytoestrogens
Diseases : Breast Cancer, Estrogen Dominance
[+]

Dietary seeweed favorably alters phytoestrogen metabolism with a likely positive change in colonic bacteria in healthy postmenopausal women. May 01, 2009

Pubmed Data : J Nutr. 2009 May;139(5):939-44. Epub 2009 Mar 25. PMID: 19321575
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Seaweed
Diseases : Estrogen Dominance
Additional Keywords : Estrogen Metabolism
[+]

Estradiol may have proinflammatory effects in older men with coronary artery disease.Dec 01, 2010

Pubmed Data : Med Sci Monit. 2010 Dec;16(12):CR593-7. PMID: 21119577
Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Coronary Artery Disease, Estrogen Dominance
Additional Keywords : Sex Hormone-Binding Globulin
[+]

Higher estradiol levels are associated with gynecomastia.Nov 02, 1984

Pubmed Data : Dtsch Med Wochenschr. 1984 Nov 2 ;109(44):1678-82. PMID: 6489180
Article Published Date : Nov 02, 1984
Study Type : Human Study
Additional Links
Diseases : Estrogen Dominance, Gynecomastia
Additional Keywords : Diseases that are Linked, Drug: Tamoxifen
Problem Substances : 17beta-estradiol
[+]

Safety: soy food consumption lowers estrogen levels in nipple aspirate fluid and serum. Jul 08, 2011

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21742946
Article Published Date : Jul 08, 2011
Study Type : Human Study
Additional Links
Substances : Soy
Diseases : Estrogen Dominance
Additional Keywords : Soy: Positive Data
[+]

Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal womenApr 30, 2006

Pubmed Data : J Nutr. 2006 May ;136(5):1270-5. PMID: 16614415
Article Published Date : Apr 30, 2006
Study Type : Human Study
Additional Links
Substances : Sesamin
Diseases : Estrogen Dominance
Therapeutic Actions : Placebo Effect
Pharmacological Actions : Antioxidants
Additional Keywords : 2-hydroxyestrone, Sex Hormone-Binding Globulin
[+]

Soy product intake is inversely associated with serum androgen and estrogen concentrations in Japanese men. Jan 01, 2000

Pubmed Data : Nutr Cancer. 2000;36(1):14-8. PMID: 10798211
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Soy
Diseases : Estradiol: Too High, Estrogen Dominance, Testosterone: Too High
Additional Keywords : Sex Hormone-Binding Globulin
[+]

Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism.Jun 01, 2010

Pubmed Data : Cancer Prev Res (Phila Pa). 2010 Jun;3(6):727-37. Epub 2010 May 25. PMID: 20501861
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Berries: All, Blueberry, Ellagic Acid, Raspberry
Diseases : Breast Cancer, Estrogen Dominance, Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios
Pharmacological Actions : Chemopreventive, Estradiol Antagonists
[+]

Brown kelp exhibits anti-estrogenic activity and mildly increases progesterone levels in female rats.Feb 01, 2005

Pubmed Data : J Nutr. 2005 Feb;135(2):296-300. PMID: 15671230
Article Published Date : Feb 01, 2005
Study Type : Animal Study
Additional Links
Substances : Seaweed: Brown
Diseases : Estrogen Dominance, Progesterone: Low
Pharmacological Actions : Secretagogue
Additional Keywords : Hormone Dependent Cancers
[+]

Consumption of bladderwrack results in an increase in the length of the menstrual cycle, and has significant anti-estrogenic and progestagenic effects.Aug 04, 2004

Pubmed Data : BMC Complement Altern Med. 2004 Aug 4;4:10. Epub 2004 Aug 4. PMID: 15294021
Article Published Date : Aug 04, 2004
Study Type : Animal Study
Additional Links
Substances : Kelp, Seaweed
Diseases : Estrogen Dominance, Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios, Menstruation Disorders, Menstruation Disturbances
Pharmacological Actions : Anti-Estrogenic, Progestagenic
[+]

Rosemary leaves enhance the metabolism of endogenous estrogens and decreases their uterotropic effect in mice. Oct 01, 1998

Pubmed Data : Carcinogenesis. 1998 Oct;19(10):1821-7. PMID: 9806165
Article Published Date : Oct 01, 1998
Study Type : Animal Study
Additional Links
Substances : Rosemary
Diseases : Endometrial Cancer, Estrogen Dominance, Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios, Fibroids: Uterine, Uterine Cancer
Additional Keywords : Plant Extracts
[+]

Rye lignan reduces estradiol-induced uterine growth.Aug 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Aug;53(8):996-1006. PMID: 19603405
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Isoflavones, Lignans, Rye
Diseases : Estrogen Dominance, Uterine Cancer
[+]

Triclosan is an endocrine disruptor which exhibits estrogen disruptive and thyroid suppressive activity in rats.Sep 01, 2010

Pubmed Data : Toxicol Sci. 2010 Sep;117(1):45-53. Epub 2010 Jun 18. PMID: 20562219
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Estrogen Dominance, Hormonal Disorders: Children, Hypothyroidism, Sexual Dysfunction
Problem Substances : Triclosan
Adverse Pharmacological Actions : Thyroid Suppressive
[+]

A wide range of metals have been identified to have estrogenic properties.May 01, 2006

Pubmed Data : J Appl Toxicol. 2006 May-Jun;26(3):191-7. PMID: 16489580
Article Published Date : May 01, 2006
Study Type : Review
Additional Links
Diseases : Cancers: Estrogen Responsive, Estrogen Dominance, Heavy Metal Toxicity
Additional Keywords : Metalloestrogens
Problem Substances : Aluminum, Antimony, Arsenite, Barium, Cadmium, Chromium Chloride, Cobalt, Industrial Copper (inorganic), Lead, Mercury, Selenite, Tin, Vanadate
Adverse Pharmacological Actions : Estrogenic
[+]

Berry components prevent oxidative damage to DNA caused by estradiol (E2) and copper chloride, in vitro. Sep 01, 2002

Pubmed Data : J Am Soc Nephrol. 2002 Sep;13(9):2299-308. PMID: 19003579
Article Published Date : Sep 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Berries: All, Blackberry, Ellagic Acid
Diseases : DNA damage, Estrogen Dominance, Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios
[+]

Cabbage and brussel sprouts act bifunctionally, like an antiestrogen at low concentrations and an estrogen agonist at high concentrations.Oct 01, 2000

Pubmed Data : J Agric Food Chem. 2000 Oct;48(10):4628-34. PMID: 11052710
Article Published Date : Oct 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Brussel sprouts, Cabbage
Diseases : Estrogen Dominance
[+]

Coffee consumption may reduce colon cancer incidence by increasing the sulfation of estrogen.Oct 01, 2006

Pubmed Data : J Nutr Biochem. 2006 Oct;17(10):697-706. Epub 2006 Jan 9. PMID: 18981586
Article Published Date : Oct 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Coffee
Diseases : Colon Cancer, Estrogen Dominance
Pharmacological Actions : Detoxifier
[+]

Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells.Jan 01, 2011

Pubmed Data : Mol Cell Biochem. 2011 Jan;347(1-2):1-11. Epub 2010 Oct 13. PMID: 20941532
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer, Estrogen Dominance
Pharmacological Actions : Apoptotic
[+]

Damiana contains compounds with anti-aromatase activity. Dec 08, 2008

Pubmed Data : J Ethnopharmacol.2008 Dec 8;120(3):387-93. Epub 2008 Sep 26. PMID: 18948180
Article Published Date : Dec 08, 2008
Study Type : In Vitro Study
Additional Links
Substances : Damiana
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Estrogen dominance (excess or unopposed estradiol) may contribute to Raynaud's phenomenon. Sep 01, 2007

Pubmed Data : Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1955-61. Epub 2007 Jul 20. PMID: 17644575
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Estrogen Dominance, Raynaud Disease
[+]

Euonymus altaus and Scutellaria barbarata have prowerful aromatase inhibiting properties.Aug 01, 2004

Pubmed Data : Immunopharmacol Immunotoxicol. 2004 Aug;26(3):315-27. PMID: 15518167
Article Published Date : Aug 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Euonymus alatus (Burning Bush), Sculletaria barbata
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Genistein suppresses estradiol-induced uterine leiomyoma cell proliferation.Dec 31, 2004

Pubmed Data : Life Sci. 2004 Dec 31;76(7):775-82. PMID: 19903033
Article Published Date : Dec 31, 2004
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Estrogen Dominance, Leiomyoma
[+]

Indole-3 carbinol is a negative regulator of estrogen. Jul 01, 2003

Pubmed Data : J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S. PMID: 12840226
Article Published Date : Jul 01, 2003
Study Type : Commentary
Additional Links
Substances : Indole-3-Carbinol
Diseases : Estrogen Dominance
[+]

Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.Sep 30, 1998

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Endocrinology. 1998 Oct ;139(10):4252-63. PMID: 9751507
Article Published Date : Sep 30, 1998
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Isoflavones
Diseases : Estrogen Dominance
Problem Substances : Mycoestrogens, Polychlorinated biphenyls (PCBs), Zearalenone (ZEA)
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Ipriflavone accelerates clearance of estradiol (E2) through enhancing the activity of the enzyme estradiol 3-glucuronide. Nov 01, 2004

Pubmed Data : Biol Pharm Bull. 2004 Nov;27(11):1844-9. PMID: 15516735
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Ipriflavone
Diseases : Estrogen Dominance, Gynecomastia
Pharmacological Actions : Estradiol 3-glucuronide enhancer
[+]

Licorice contains a compound (liquiritigenin) with aromatase inhibitory action 10 times more potent than the first generation aromatase inhibitor aminoglutethimide (Cytadren). Sep 15, 2008

Pubmed Data : Bioorg Med Chem. 2008 Sep 15;16(18):8466-70. Epub 2008 Aug 19. PMID: 18778944
Article Published Date : Sep 15, 2008
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Lignans and flavonoids act as aromatase inhibitors in human preadipocytes. Aug 01, 1994

Pubmed Data : J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12. PMID: 8049151
Article Published Date : Aug 01, 1994
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Flavonoids, Lignans
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production. Apr 01, 2005

Pubmed Data : J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID: 15876411
Article Published Date : Apr 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Enterolactone, Genistein, Lignans
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Mangosteen contains xanthones with aromatase inhibitory activity.Jul 01, 2008

Pubmed Data : J Nat Prod. 2008 Jul;71(7):1161-6. Epub 2008 Jun 18. PMID: 18558747
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen
Diseases : Estrogen Dominance
Pharmacological Actions : Anticarcinogenic Agents, Aromatase Inhibitors
Additional Keywords : Xanthones
[+]

Melatonin counteracts the pro-carcinogenic properties of estradiol in breast cancer cells. Aug 01, 2009

Pubmed Data : J Pineal Res. 2009 Aug;47(1):23-31. Epub 2009 Jun 10. PMID: 19522736
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : BRCA-1 Downregulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Natural plant compounds may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estrogeDec 01, 1998

Pubmed Data : Environ Health Perspect. 1998 Dec;106(12):807-12. PMID: 9831541
Article Published Date : Dec 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Isoflavones
Diseases : Breast Cancer, Estrogen Dominance, Pesticide Toxicity , Xenobiotic Exposures
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
[+]

Phytoestrogens-mediated induction of phase II detoxification enzymes may be responsible for their protective effect against estrogen-induced breast cancer. Jan 01, 2005

Pubmed Data : Biochem J. 2005 Jan 1;385(Pt 1):279-87. PMID: 15456407
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Genistein, Resveratrol
Diseases : Breast Cancer, DNA damage, Estrogen Dominance
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Estrogen Receptor Beta, Stilbenes
[+]

Resveratrol and NAC may prevent DNA-estrogen adducts associated with carcinogenesis. Jan 01, 2010

Pubmed Data : Future Oncol. 2010 Jan;6(1):75-91. PMID: 20021210
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Resveratrol, Stilbenes
Diseases : Breast Cancer, Cancers: All, Cancers: Estrogen Responsive, DNA damage, Estrogen Dominance
Pharmacological Actions : Antineoplastic Agents, Antioxidants
[+]

Resveratrol may reduce the pro-coagulant adverse effects associated with high estrogen conditions.Jan 01, 2011

Pubmed Data : Thromb Res. 2011 Jan;127(1):e1-7. PMID: 20926118
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Contraception, Estrogen Dominance, Hormone Replacement Therapy, Thrombosis
Pharmacological Actions : Anti-thrombotic
[+]

The soy isoflavone daidzein enhances the clearance of estradiol (E2) from the body possibly contributing to its chemopreventive effect.Feb 01, 1999

Pubmed Data : J Gastroenterol. 1999 Feb;34(1):75-82. PMID: 16598814
Article Published Date : Feb 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Breast Cancer, Endometrial Cancer, Estrogen Dominance
Pharmacological Actions : Chemopreventive, Estradiol 3-glucuronide enhancer
[+]

Unlike tamoxifen and estradiol pomegranate exerts selective estrogen receptor modulator activity without uterotrophic properties.Aug 10, 2011

Pubmed Data : J Nutr Biochem. 2011 Aug 10. Epub 2011 Aug 10. PMID: 21839626
Article Published Date : Aug 10, 2011
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Estrogen Deficiency, Estrogen Dominance
Pharmacological Actions : Selective estrogen enzyme modulator (SEEM)
Additional Keywords : HRT Alternatives, Superiority of Natural Substances versus Drugs
Problem Substances : 17beta-estradiol, Tamoxifen
Adverse Pharmacological Actions : Uterotrophic
[+]

Vitamin D3 down-regulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cells.Aug 01, 2000

Pubmed Data : Clin Cancer Res. 2000 Aug;6(8):3371-9. PMID: 10955825
Article Published Date : Aug 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Estrogen Antagonists
Additional Keywords : Estrogen Receptor Positive Breast Cancer
[+]

Yerba mate contains a potent aromatase inhibitor. Sep 01, 2008

Pubmed Data : Eur J Med Chem. 2008 Sep;43(9):1865-77. Epub 2007 Dec 7. PMID: 18192087
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Yerba Mate
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors

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