Fluorosis

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12 Substances Researched for Fluorosis
NameACCKFocus
Calcium212Locked
Vitamin D212Locked
Selenium211Locked
Tamarind110Locked
Vitamin C110Locked
Water110Locked
Moringa oleifera24Locked
Citrus naringin12Locked
Gastrodin12Locked
Lycopene12Locked
Spirulina12Locked
Vitamin E11Locked
7 Problem Substances Researched for Fluorosis
NameACCKFocus
Sodium Fluoride31164Locked
Fluoride1077Locked
Infant Formula432Locked
Flouride110Locked
Public Drinking Water110Locked
Sugary soda110Locked
Perfluorinated Compound Toxicity12Locked

View the Evidence:
42 Abstracts with Fluorosis Research

[+]

Fluoride concentration in ground water and prevalence of dental fluorosis in Ethiopian Rift Valley.Oct 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Public Health. 2019 Oct 16 ;19(1):1298. Epub 2019 Oct 16. PMID: 31619212
Article Published Date : Oct 15, 2019
Study Type : Meta Analysis, Review
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Additional Keywords : Water Fluoridation
Problem Substances : Sodium Fluoride
[+]

Exposure to high levels of fluoride may adversely influence children's intelligence development.Dec 01, 2008

Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2008 Dec;10(6):723-5. PMID: 19102839
Article Published Date : Dec 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Childhood Cognitive Disorders, Cognitive Decline/Dysfunction, Fluoride Toxicity , Fluorosis, Intelligence Quotient (IQ): Low/Impaired, Prenatal Nutrition: Learning/Intelligence of Offspring
Problem Substances : Fluoride
Adverse Pharmacological Actions : Neurotoxic
[+]

Infant formula consumption may be associated with an increased risk of developing at least some detectable level of enamel fluorosis.Jan 01, 2009

Pubmed Data : Evid Based Dent. 2009;10(3):73. PMID: 19820737
Article Published Date : Jan 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Fluoride, Infant Formula
[+]

The use of fluoride supplements during the first 6 years of life is associated with a significant increase in the risk of developing dental fluorosis.Jan 31, 1999

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Community Dent Oral Epidemiol. 1999 Feb ;27(1):48-56. PMID: 10086926
Article Published Date : Jan 31, 1999
Study Type : Meta Analysis
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Water fluoridation less effective now than in past.Oct 03, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cochrane Database Syst Rev. 2024 Oct 4 ;10(10):CD010856. Epub 2024 Oct 4. PMID: 39362658
Article Published Date : Oct 03, 2024
Study Type : Meta Analysis
Additional Links
Diseases : Dental Caries, Fluorosis
Problem Substances : Sodium Fluoride
[+]

An intervention with safe drinking water for 5 years in intervention group-mitigated clinical and subclinical symptoms of fluorosis.Feb 01, 2018

Pubmed Data : Environ Monit Assess. 2018 Feb 2 ;190(3):110. Epub 2018 Feb 2. PMID: 29396763
Article Published Date : Feb 01, 2018
Study Type : Human Study
Additional Links
Substances : Water
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Dental fluorosis results from fluoride intake by different sources. Jul 01, 2009

Pubmed Data : Gac Med Mex. 2009 Jul-Aug;145(4):263-7. PMID: 20073427
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Diseases : Fluorosis
Problem Substances : Fluoride, Sodium Fluoride, Sugary soda
[+]

Excessive fluoride in water causes severe dental fluorosis and raises fracture risks, urging defluoridation in affected areas.Aug 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2024 Sep 1 ;282:116705. Epub 2024 Jul 13. PMID: 39003868
Article Published Date : Aug 31, 2024
Study Type : Human Study
Additional Links
Diseases : Bone Fractures, Fluorosis
Problem Substances : Fluoride
[+]

Fluorosis is associated with impaired cognition in children.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Indian Acad Neurol. 2021 ;24(5):715-720. Epub 2020 Nov 6. PMID: 35002129
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Diseases : Childhood Cognitive Disorders, Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Health effects of groundwater fluoride contamination.Mar 31, 2009

Pubmed Data : Clin Toxicol (Phila). 2009 Apr ;47(4):292-5. PMID: 19274500
Article Published Date : Mar 31, 2009
Study Type : Human Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Flouride, Sodium Fluoride
[+]

Health impact of supplying safe drinking water containing fluoride below permissible level on flourosis patients in a fluoride-endemic rural area of West Bengal.Dec 31, 2010

Pubmed Data : Indian J Public Health. 2011 ;55(4):303-8. PMID: 22298140
Article Published Date : Dec 31, 2010
Study Type : Human Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Additional Keywords : Water Fluoridation
Problem Substances : Sodium Fluoride
[+]

High prevalence of dental fluorosis among schoolchildren in three villages in Sri Lanka.Jan 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ceylon Med J. 2017 12 26 ;62(4):218-221. PMID: 29390597
Article Published Date : Jan 25, 2017
Study Type : Human Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Infants fully formula-fed on formulae prepared with optimally fluoridated water (0.7-1.0 mg/L) have a high probability of exceeding the upper limit for fluoride and are at increased risk of dental fluorosis.Jun 02, 2010

Pubmed Data : J Public Health Dent. 2010 Jun 2. Epub 2010 Jun 2. PMID: 20545827
Article Published Date : Jun 02, 2010
Study Type : Human Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Fluoride, Infant Formula, Public Drinking Water
[+]

Long-term high intake of fluoride can cause skeletal fluorosis in patients with diabetes insipidus.Jul 24, 2017

Pubmed Data : Zhongguo Gu Shang. 2017 Jul 25 ;30(7):651-655. PMID: 29424157
Article Published Date : Jul 24, 2017
Study Type : Human Study
Additional Links
Diseases : Diabetes Insipidus, Fluorosis
Additional Keywords : Risk Factors
[+]

Reversal of fluorosis in children with ascorbic acid, calcium and vitamin D3.Sep 30, 1996

Pubmed Data : Acta Paediatr Jpn. 1996 Oct ;38(5):513-9. PMID: 8942013
Article Published Date : Sep 30, 1996
Study Type : Human Study
Additional Links
Substances : Calcium, Vitamin C, Vitamin D
Diseases : Fluorosis
Pharmacological Actions : Detoxifier
Problem Substances : Sodium Fluoride
[+]

Selenium alleviates apoptosis induced by fluoride through improving the expression of HSP70 and reduces oxidative stress.Apr 07, 2020

Pubmed Data : Eur J Pharmacol. 2020 Apr 8 ;878:173098. Epub 2020 Apr 8. PMID: 32275908
Article Published Date : Apr 07, 2020
Study Type : Human Study
Additional Links
Substances : Selenium
Diseases : Fluorosis
Pharmacological Actions : Antioxidants, Heat Shock Protein Inducer
[+]

Tamarind intake is likely to help in delaying progression of fluorosis by enhancing urinary excretion of fluoride.Jan 01, 2002

Pubmed Data : Eur J Clin Nutr. 2002 Jan;56(1):82-5. PMID: 11840184
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Substances : Tamarind
Diseases : Fluoride Toxicity , Fluorosis
[+]

Fluorosilicic acid and cotinine, separately and in combination, induce genotoxicity and telomeric reduction in human osteoblast cell line MG63.Dec 31, 2021

Pubmed Data : Mutat Res Genet Toxicol Environ Mutagen. 2022 ;876-877:503474. Epub 2022 Feb 17. PMID: 35483789
Article Published Date : Dec 31, 2021
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage, Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

An interventional clinical trial investigating the effects of Spirulina platensis on dental fluorosis and antioxidant system.Oct 05, 2023

Pubmed Data : Sci Rep. 2023 Oct 6 ;13(1):16858. Epub 2023 Oct 6. PMID: 37803131
Article Published Date : Oct 05, 2023
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Dental Fluorosis, Fluoride Toxicity , Fluorosis
Pharmacological Actions : Antioxidants
Problem Substances : Sodium Fluoride
[+]

Calcium and vitamin D supplementation effectively alleviates dental and skeletal fluorosis and retain elemental homeostasis in mice.Jul 31, 2021

Pubmed Data : Biol Trace Elem Res. 2021 Aug ;199(8):3035-3044. Epub 2020 Oct 14. PMID: 33057951
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Calcium, Vitamin D
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Cognitive decline of rats with chronic fluorosis is associated with alterations in hippocampal calpain signaling.Sep 30, 2020

Pubmed Data : Biol Trace Elem Res. 2020 Oct ;197(2):495-506. Epub 2019 Dec 3. PMID: 31797207
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Neurotoxic
[+]

Effect of Moringa oleifera leaves on hematological profile of fluorosis affected rats.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioinformation. 2022 ;18(1):14-18. Epub 2022 Jan 31. PMID: 35815197
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Fluorosis
Problem Substances : Sodium Fluoride
[+]

Exposure to high-fluoride resulted in lower body weight and exercise capacity in mice.Feb 15, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Feb 16 ;8(1):3211. Epub 2018 Feb 16. PMID: 29453343
Article Published Date : Feb 15, 2018
Study Type : Animal Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Fluoride exposure disrupts enterohepatic function by damaging liver and intestinal tissues, altering bile acid synthesis, and reducing beneficial gut bacteria like Bifidobacterium.Aug 04, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Adv Res. 2024 Aug 5. Epub 2024 Aug 5. PMID: 39097090
Article Published Date : Aug 04, 2024
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Dysbiosis, Dysbiosis: Bifidobacteria Deficiency, Fluorosis
Problem Substances : Perfluorinated Compound Toxicity
[+]

Gastrodin alleviates bone damage by modulating protein expression and tissue redox state.Jan 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Open Bio. 2020 11 ;10(11):2404-2416. Epub 2020 Oct 21. PMID: 33010109
Article Published Date : Jan 10, 2020
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Fluorosis
Pharmacological Actions : Antioxidants, Osteoprotective
Problem Substances : Fluoride
[+]

Lycopene significantly combated sodium fluoride induced ameloblasts apoptosis and dental fluorosis.Nov 17, 2016

Pubmed Data : Chem Biol Interact. 2016 Nov 18 ;261:27-34. Epub 2016 Nov 18. PMID: 27871895
Article Published Date : Nov 17, 2016
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Fluoride Toxicity , Fluorosis
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Superoxide Dismutase Up-regulation
Problem Substances : Sodium Fluoride
[+]

Neuroprotective effect by naringin against fluorosis-induced neurodegeneration.Jun 06, 2023

Pubmed Data : Neuroreport. 2023 Jun 7 ;34(9):449-456. Epub 2023 Apr 28. PMID: 37161984
Article Published Date : Jun 06, 2023
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Fluorosis
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Fluoride
[+]

Sodium fluoride exposure induces developmental toxicity and cardiotoxicity in zebrafish embryos.Sep 16, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Trace Elem Res. 2024 Sep 17. Epub 2024 Sep 17. PMID: 39287768
Article Published Date : Sep 16, 2024
Study Type : Animal Study
Additional Links
Diseases : Fluorosis
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Cardiotoxic
[+]

Sodium fluoride induces apoptosis in the kidney of rats through caspase-mediated pathways and DNA damage.Aug 31, 2014

Pubmed Data : J Physiol Biochem. 2014 Sep ;70(3):857-68. Epub 2014 Aug 27. PMID: 25158646
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Diseases : DNA damage, Fluoride Toxicity , Fluorosis, Kidney Damage: Chemically-Induced
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Apoptotic, Renotoxic
[+]

Supplementation of dried M. oleifera fruit powder to fluorosis affected calves resulted in significant reduction in plasma fluoride level.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Vet World. 2015 Nov ;8(11):1364-9. Epub 2015 Nov 28. PMID: 27047044
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Fluoride Toxicity , Fluorosis
[+]

A comparative evaluation of the fluoride content in commercially available infant formulae in India.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Indian Soc Pedod Prev Dent. 2023 Oct 1 ;41(4):328-334. Epub 2024 Jan 18. PMID: 38235820
Article Published Date : Sep 30, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Additional Keywords : Water Fluoridation
Problem Substances : Infant Formula, Sodium Fluoride
[+]

A relationship was identified between drinking fluoridated water from wells and the prevalence of fluorosis in individuals up to 18 years old.Dec 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Odontol Latinoam. 2023 Dec 31 ;36(3):169-176. PMID: 38345279
Article Published Date : Dec 30, 2023
Study Type : Review
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

A review of the effects of chronic fluorosis on the brain.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2022 Oct 1 ;244:114021. Epub 2022 Aug 29. PMID: 36049331
Article Published Date : Sep 30, 2022
Study Type : Review
Additional Links
Diseases : Fluoride Toxicity , Fluorosis, Learning disorders, Memory Disorders, Oxidative Stress
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Neurotoxic
[+]

Apoptosis and inflammation involved with fluoride-induced bone injuries. Jul 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Jul 31 ;16(15). Epub 2024 Jul 31. PMID: 39125380
Article Published Date : Jul 30, 2024
Study Type : Review
Additional Links
Diseases : Fluoride Toxicity , Fluorosis, Inflammation
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Apoptotic
[+]

Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells.Aug 31, 2017

Pubmed Data : Environ Toxicol Pharmacol. 2017 Sep ;54:74-79. Epub 2017 Jun 30. PMID: 28697452
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Fluoride, Sodium Fluoride
Adverse Pharmacological Actions : Apoptotic, Neurotoxic
[+]

Fluoride exposure provokes mitochondria-mediated apoptosis and increases mitophagy in osteocytes.Jul 31, 2023

Pubmed Data : Biol Trace Elem Res. 2023 Aug ;201(8):3994-4007. Epub 2022 Oct 18. PMID: 36255553
Article Published Date : Jul 31, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis, Oxidative Stress
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Apoptotic
[+]

Fluoride in drinking water and skeletal fluorosis: a review of the global impact.May 31, 2020

Pubmed Data : Curr Environ Health Rep. 2020 Jun ;7(2):140-146. PMID: 32207100
Article Published Date : May 31, 2020
Study Type : Review
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

Fluoride induces apoptosis in H9c2 cardiomyocytes.Apr 30, 2017

Pubmed Data : Chemosphere. 2017 May 1 ;182:159-165. Epub 2017 May 1. PMID: 28494360
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Fluorosis
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Cardiotoxic
[+]

Potential risk of dental fluorosis associated with different baby formulas and water brands marketed in Spain.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Pediatr Dent. 2024 Jan ;48(1):111-119. Epub 2024 Jan 3. PMID: 38239163
Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Infant Formula, Sodium Fluoride
[+]

Role of fluoride induced histone trimethylation in development of skeletal fluorosis.Dec 31, 2017

Pubmed Data : Environ Toxicol Pharmacol. 2018 Jan ;57:159-165. Epub 2017 Dec 17. PMID: 29275289
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis
Problem Substances : Sodium Fluoride
[+]

The effect of vitamin E and selenium combination in repairing fluoride-induced DNA damage to NRK-52E cells.Sep 30, 2020

Pubmed Data : Mol Biol Rep. 2020 Oct ;47(10):7761-7770. Epub 2020 Oct 6. PMID: 33025505
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Selenium, Vitamin E
Diseases : DNA damage, Fluoride Toxicity , Fluorosis
Pharmacological Actions : DNA Repair Up-regulation, Genoprotective
Problem Substances : Sodium Fluoride
[+]

This study has provided new evidence for the role of FGF21/ERK in fluoride-induced skeletal muscle damage.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2023 Mar 1 ;252:114626. Epub 2023 Feb 8. PMID: 36764073
Article Published Date : Feb 28, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Fluoride Toxicity , Fluorosis, Muscle Damage
Problem Substances : Fluoride, Sodium Fluoride

Copyright: agephotography / 123RF Stock Photo

Fluorosis Related Articles

Open Letter to Nutritionists About the Fluoride Deception
Written by Karen Spencer
Fluoride is not a nutrient of any kind - essential, non-essential or micronutrient. Consumption does not provide any dental benefit, and there is no such thing as a fluoride deficiency
Dispensing with Fluoride
Written by Orthomolecular News Service
Evidence-based medicine requires evidence before medicating. Fluoridation of water is not evidence-based. It has not been tested in well-controlled studies. Fluoridation of public water is a default medication, since you have to deliberately avoid it if you do not want to take it.
JAMA Bombshell: Fluoride in Pregnancy Linked to Worse Child Behavior Outcomes
Written by GreenMedInfo Research Group
Fluoride - long added to public water supplies for dental health - may come at a previously unrecognized cost: harming fetal brain development and leading to neurobehavioral problems in children
Fluoride's IQ Impact: New Gov. Study Adds to Growing Body of Evidence of HARM
Written by GreenMedInfo Research Group
A groundbreaking government report has found a link between high fluoride levels in drinking water and lower IQs in children, adding fuel to a decades-long debate about the safety of this widespread public health measure.
Fluoride Exposure May Contribute to Degenerative Eye Diseases
Written by GreenMedInfo Research Group
Yet another study adds to the growing body of evidence of fluoride toxicity, shedding light on how it potentially contributes to degenerative eye diseases. Findings like this once again put into question the need for fluoride as a protective agent against tooth decay and peel more layers of the substance's toxic and disease-inducing effects

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