Gallbladder Disease

Name	AC	CK
Curcumin	10	64
Vegetables: All	4	50
Fruit: All	3	40
Chelidonium	1	30
Nuts	2	30
Peanut	2	30
Fiber	3	21
Lecithin	2	21
Green Tea	2	20
Vitamin D	2	20
EPA (Eicosapentaenoic Acid)	2	14
Fish Oil	2	14
Polyphenols	2	12
Flavonoids	2	11
Magnesium	2	11
Resveratrol	2	11
Beans: All	1	10
Black Tea	1	10
Coffee	1	10
DHA (Docosahexaenoic Acid)	1	10
Fish	1	10
Omega-3 Fatty Acids	1	10
Sesbania grandiflora	1	10
Tea: Black	1	10
Ursodeoxycholic acid	1	10
Wheat Bran	1	10
Garlic	5	8
Vitamin C	3	7
Milk Thistle	3	6
Onion	3	6
Magnolol	1	5
EGCG (Epigallocatechin gallate)	1	4
Psyllium	2	4
Traditional Chinese Medicine: Mylabris	3	4
Vitamin E	2	4
Artemisinin	2	3
Fenugreek	2	3
Ginsenosides	2	3
Homeopathic Medicine: All	1	3
Ursolic Acid	2	3
Betulinic acid	1	2
Cayenne	1	2
Chaparral	1	2
Daikon radish	1	2
Gardenia	1	2
Lycopene	1	2
Magnesium Sulfate	1	2
Melatonin	1	2
Nigella sativa (aka Black Seed)	1	2
Peony	1	2
Piperine	1	2
R-alpha lipoic acid	1	2
Red Yeast Rice	1	2
Rhubarb	1	2
Rosmarinic acid	1	2
Shikonin	1	2
Thymoquinone	1	2
Arctigenin	1	1
Capsaicin	1	1
Emodin	1	1
Genistein	1	1
Green Leafy Vegetables	1	1
Hesperidin	1	1
Lignans	1	1
Onions	1	1
Oridonin	1	1
Peppermint	1	1
Piperlongumine	1	1
Pterostilbene	1	1
Schisandra	1	1
Sea buckthorn	1	1
Turmeric	1	1

Name	AC	CK
Statin Drugs	8	30
Simvastatin	3	15
Artificially Sweetened Beverages	1	10
Gliadin	1	10
Gluten	1	10
Sugar Sweetened Beverages	1	10
Atorvastatin	3	9
Cerivastatin	1	3
Lovastatin	1	3
Pravastatin	1	3
Quizalofop-P-ethyl	1	3
Aluminum	1	2
Cyclosporins	1	2

Name	AC	CK
Doing Nothing	1	20
Watchful Waiting	1	20
Laser puncture	1	10

Name	AC	CK	Focus
Surgical Procedures	1	20
Vaccination: All	1	2

[+]

This study suggests vegetables and fruits consumption is correlated with a significantly reduced risk of gallstone disease.Jun 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2019 Jul ;98(28):e16404. PMID: 31305451

Article Published Date : Jun 30, 2019

Study Type : Meta Analysis, Review

Additional Links

Substances : Fruit: All, Vegetables: All

Diseases : Gallstones

Additional Keywords : Risk Reduction

[+]

A diet rich in refined carbohydrate increases bile cholesterol saturation and consequently gallstone formation. Jan 01, 1983

Click here to read the entire abstract

Pubmed Data : Gut. 1983 Jan;24(1):2-6. PMID: 6293939

Article Published Date : Jan 01, 1983

Study Type : Human Study

Additional Links

Diseases : Gallstones

Additional Keywords : Refined Carbohydrate Diet

[+]

A vegetarian diet is correlated with significantly decreased risk for gallstones in women. Sep 01, 2003

Click here to read the entire abstract

Pubmed Data : Indian J Med Sci. 2003 Sep;57(9):387-93. PMID: 3926039

Article Published Date : Sep 01, 2003

Study Type : Human Study

Additional Links

Diseases : Gallstones

[+]

Celiac disease has a high prevalance rate in autoimmune cholestatic liver disorders.Oct 01, 2002

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2002 Oct;97(10):2609-13. PMID: 12385447

Article Published Date : Oct 01, 2002

Study Type : Human Study

Additional Links

Diseases : Autoimmune Diseases, Celiac Disease, Cholestasis, Cholestasis: Autoimmune

Additional Keywords : Diseases that are Linked

Problem Substances : Gliadin, Gluten

[+]

Chelidonium and turmeric root extract have a therapeutic effect on upper abdominal pain due to functional disorders of the biliary system. Aug 15, 1999

Click here to read the entire abstract

Pubmed Data : Med Klin (Munich). 1999 Aug 15;94(8):425-30. PMID: 10495621

Article Published Date : Aug 15, 1999

Study Type : Human Study

Additional Links

Substances : Chelidonium, Curcumin

Diseases : Biliary Dyskinesia, Cholestasis, Dyspepsia, Gallbladder Disease

Pharmacological Actions : Cholagogues and Choleretics

Additional Keywords : Plant Extracts

[+]

Curcumin has a contractive effect on human gallbladder function.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : J Bras Pneumol. 2006 Jan-Feb;32(1):66-74. PMID: 10102956

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Cholestasis

Pharmacological Actions : Cholagogues and Choleretics

[+]

Curcumin has gall-bladder emptying properties. Jan 01, 2002

Click here to read the entire abstract

Pubmed Data : Asia Pac J Clin Nutr. 2002;11(4):314-8. PMID: 12495265

Article Published Date : Jan 01, 2002

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Cholestasis

Pharmacological Actions : Cholagogues and Choleretics

[+]

Dietary fiber protected against acute pancreatitis related and unrelated to gallstones, while coffees protection was unrelated to gallstones. Sep 04, 2016

Click here to read the entire abstract

Pubmed Data : Clin Gastroenterol Hepatol. 2016 Sep 5. Epub 2016 Aug 5. PMID: 27609706

Article Published Date : Sep 04, 2016

Study Type : Human Study

Additional Links

Substances : Coffee, Fiber

Diseases : Gallstones, Pancreatitis

Additional Keywords : Risk Reduction

[+]

Fish oil fatty acids reduce the cholesterol saturation index and nucleation time in obese subjects, which probably result in prevention of gallstone formation. Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : Appl Ergon. 2009 Nov;40(6):1047-54. Epub 2009 Jun 21. PMID: 11533270

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Substances : Fish Oil

Diseases : Gallstones

[+]

Frequent nut consumption decreases the risk of cholecystectomy in women.Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2004 Jul;80(1):76-81. PMID: 15213031

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : Nuts, Peanut

Diseases : Cholecystitis, Gallbladder Inflammation, Gallstones

[+]

Frequent nut consumption is associated with a reduced risk of gallstone disease in men.Nov 15, 2004

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2004 Nov 15;160(10):961-8. PMID: 15522852

Article Published Date : Nov 15, 2004

Study Type : Human Study

Additional Links

Substances : Nuts, Peanut

Diseases : Gallstones

[+]

High consumption of sweetened beverages may increase the risk of biliary tract cancer and gallbladder cancer.Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 2016 Oct ;108(10). Epub 2016 Jun 8. PMID: 27281756

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Diseases : Cholangiocarcinoma, Gallbladder Cancer

Additional Keywords : Increased Risk

Problem Substances : Artificially Sweetened Beverages, Sugar Sweetened Beverages

[+]

High inake of fried food and constipation are associated with increased risk of bile duct and gallbladder cancer. The consumption of boiled beans and fish may reduce the risk.Jun 01, 2005

Click here to read the entire abstract

Pubmed Data : J Epidemiol. 2005 Jun;15 Suppl 2:S150-6. PMID: 16127227

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Substances : Beans: All , Fish

Diseases : Constipation, Gallbladder Cancer

Additional Keywords : Diseases that are Linked

[+]

Increased fruit and vegetable consumption may decrease a risk of extrahepatic bile duct cancer.Oct 30, 2016

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2016 Oct 31. Epub 2016 Aug 31. PMID: 27798952

Article Published Date : Oct 30, 2016

Study Type : Human Study

Additional Links

Substances : Fruit: All, Vegetables: All

Diseases : Cholangiocarcinoma, Gallbladder Cancer

Additional Keywords : Risk Reduction

[+]

Laser reflex therapy improves patients with chronic acalculous cholecystitis (biliary dyskinesia) Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Ter Arkh. 2009;81(2):57-61. PMID: 19334492

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Biliary Dyskinesia

Therapeutic Actions : Laser puncture

[+]

Lecithin contributes to gallstone dissolution or reduction in size, as well as reducing the lithogenic index of bile. Dec 06, 1975

Click here to read the entire abstract

Pubmed Data : Lancet. 1975 Dec 6;2(7945):1124-6. PMID: 53604

Article Published Date : Dec 06, 1975

Study Type : Human Study

Additional Links

Substances : Lecithin

Diseases : Cholestasis, Gallstones

[+]

Low antioxidant levels, impaired glutathione reserve in the liver, and low levels of sulphur amino acids are associated with the development of gallstones. Nov 01, 2004

Click here to read the entire abstract

Pubmed Data : Clin Chim Acta. 2004 Nov;349(1-2):157-65. PMID: 15469869

Article Published Date : Nov 01, 2004

Study Type : Human Study

Additional Links

Diseases : Gallstones

[+]

Magnesium consumption has a protective role in prevention of symptomatic gallstone disease among men. Feb 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2008 Feb;103(2):375-82. Epub 2007 Dec 12. PMID: 18076730

Article Published Date : Feb 01, 2008

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Gallstones

[+]

Moderate tea drinking decreased the associated risk of gallstones in a Taiwanese population.Aug 21, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Clin Nutr. 2018 Aug 22. Epub 2018 Aug 22. PMID: 30135551

Article Published Date : Aug 21, 2018

Study Type : Human Study

Additional Links

Substances : Black Tea, Green Tea

Diseases : Gallstones

Additional Keywords : Risk Reduction

[+]

Omega-3 fatty acids prevent the formation of urinary calcium oxalate stone formation.Feb 01, 2011

Click here to read the entire abstract

Pubmed Data : J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 21168878

Article Published Date : Feb 01, 2011

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Bladder Stones, Gallstones, Kidney Stones

[+]

Patients with pre-operative dyspeptic symptoms, notably bad taste and flatulence, have an increased risk of negative post-cholecystectomy outcomes at 6 weeks. Feb 01, 2009

Click here to read the entire abstract

Pubmed Data : J Gastrointest Surg. 2009 Feb;13(2):304-11. Epub 2008 Oct 16. PMID: 18923876

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Diseases : Dyspepsia, Gallbladder Inflammation, Gallbladder Surgery: Removal

[+]

Resveratrol could be a potential therapeutic target for intrahepatic cholestasis of pregnancy.May 31, 2018

Click here to read the entire abstract

Pubmed Data : Hepatol Res. 2018 Jun 1. Epub 2018 Jun 1. PMID: 29855113

Article Published Date : May 31, 2018

Study Type : Human Study

Additional Links

Substances : Resveratrol

Diseases : Cholestasis, Pregnancy Complications

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Tea consumption reduces the risk of biliary tract and gallbladder diseases.Nov 01, 2005

Click here to read the entire abstract

Pubmed Data : Zhonghua Zhong Liu Za Zhi. 2005 Nov;27(11):667-71. PMID: 16438888

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Substances : Flavonoids, Green Tea, Polyphenols, Tea: Black

Diseases : Bile Duct Cancer, Gallbladder Cancer

Pharmacological Actions : Chemopreventive

[+]

The consumption of fruits and vegetables has a protective effect against the development of bladder cancer.Aug 01, 2002

Click here to read the entire abstract

Pubmed Data : Eur J Cancer Prev. 2002 Aug;11(4):365-8. PMID: 12195163

Article Published Date : Aug 01, 2002

Study Type : Human Study

Additional Links

Substances : Fruit: All, Vegetables: All

Diseases : Gallbladder Cancer

Pharmacological Actions : Chemopreventive

[+]

The leaf juice of S. grandiflora demonstrates significant antiurolithiatic activity against calcium oxalate-type stones. Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Nat Med (Tokyo). 2008 Jul;62(3):300-7. Epub 2008 Apr 12. PMID: 18408896

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Sesbania grandiflora

Diseases : Gallstones, Kidney Stones

Pharmacological Actions : Antiurolithiatic

[+]

The risk of gallbladder cancer is inversely related to the level of vegetable consumption. Apr 01, 2006

Click here to read the entire abstract

Pubmed Data : Eur J Cancer Prev. 2006 Apr;15(2):134-7. PMID: 16523010

Article Published Date : Apr 01, 2006

Study Type : Human Study

Additional Links

Substances : Vegetables: All

Diseases : Gallbladder Cancer

[+]

This is the first study to discover a potential association of the gut microbiota dysbiosis that is present among gallstone patients.Sep 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Genomics. 2013 Oct 1 ;14:669. Epub 2013 Oct 1. PMID: 24083370

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Diseases : Dysbiosis, Gallstones

Additional Keywords : Microbiota

[+]

Ursodeoxycholic acid has been reported to ameliorate cholestatic hepatitis induced by high levels of vitamin A. Oct 01, 2007

Click here to read the entire abstract

Pubmed Data : Z Gastroenterol. 2007 Oct;45(10):1063-6. PMID: 17924304

Article Published Date : Oct 01, 2007

Study Type : Human Study

Additional Links

Substances : Ursodeoxycholic acid

Diseases : Cholestasis, Hepatitis: Vitamin A Induced

[+]

Vitamin D deficiency is associated with gallbladder stasis and gallstones. May 11, 2015

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2015 May 12. Epub 2015 May 12. PMID: 25963323

Article Published Date : May 11, 2015

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Gallstones, Vitamin D Deficiency

Additional Keywords : Increased Risk, Risk Reduction

[+]

Vitamin D might have an impact on gallstone disease. Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Endocrine. 2016 Oct 1. Epub 2016 Aug 1. PMID: 27696253

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Gallstones, Vitamin D Deficiency

Additional Keywords : Risk Reduction

[+]

Wheat bran consumption prevents cholesterol gallstones. Aug 24, 1984

Click here to read the entire abstract

Pubmed Data : Dtsch Med Wochenschr. 1984 Aug 24;109(34):1284-8. PMID: 6088204

Article Published Date : Aug 24, 1984

Study Type : Human Study

Additional Links

Substances : Fiber, Wheat Bran

Diseases : Gallstones

[+]

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Sci. 2015 Oct ;106(10):1341-50. PMID: 26250568

Article Published Date : Sep 30, 2015

Study Type : Human In Vitro

Additional Links

Substances : Magnolol

Diseases : Gallbladder Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : Clin Drug Investig. 2010 ;30(3):205-9. PMID: 20155993

Article Published Date : Jan 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Alkaline Phosphatase: Elevated, Bile Duct Injury, Bilirubin: Elevated, Cholangiolitis, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

[+]

A homeopathic approach to treat patients with advanced gallbladder, periampullary, and liver carcinomas.Jan 31, 2012

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2012 Feb ;18(2):180-6. PMID: 22339106

Article Published Date : Jan 31, 2012

Study Type : Human: Case Report

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Gallbladder Cancer, Liver Cancer

[+]

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Gastroenterol Hepatol. 2006 Jan ;29(1):21-4. PMID: 16393626

Article Published Date : Jan 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223

Article Published Date : May 01, 1999

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, GGT, Hepatitis: Cholestatic, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Pravastatin , Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Click here to read the entire abstract

Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141

Article Published Date : May 18, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Cerivastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578

Article Published Date : Jul 01, 2008

Study Type : Human: Case Report

Additional Links

Diseases : Bile Duct Injury, Chemically-Induced Liver Damage, Cholestasis, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Cholestatic jaundice during lovastatin medication has been reported. May 10, 1991

Click here to read the entire abstract

Pubmed Data : Dtsch Med Wochenschr. 1991 May 10 ;116(19):739-40. PMID: 2026107

Article Published Date : May 10, 1991

Study Type : Human: Case Report

Additional Links

Diseases : Cholestasis, Jaundice, Liver Damage: Drug-Induced, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Lovastatin-induced cholestasis has been reported. Feb 01, 1993

Click here to read the entire abstract

Pubmed Data : CMAJ. 1993 Feb 1 ;148(3):374. PMID: 8439902

Article Published Date : Feb 01, 1993

Study Type : Human: Case Report

Additional Links

Diseases : Cholestasis, Statin-Induced Pathologies

Problem Substances : Lovastatin

Adverse Pharmacological Actions : Hepatotoxic

[+]

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2007 Oct ;115(10):1479-81. PMID: 17938739

Article Published Date : Oct 01, 2007

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Quizalofop-P-ethyl

Adverse Pharmacological Actions : Hepatotoxic

[+]

Oroxylin A exerts its antitumor effects in human gallbladder cancer.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2020 ;43(10):1511-1518. PMID: 32999161

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Gallbladder Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Click here to read the entire abstract

Pubmed Data : Recenti Prog Med. 1991 Apr ;82(4):233-5. PMID: 1857844

Article Published Date : Apr 01, 1991

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Elevated: ALT, GGT, Hepatitis: Cholestatic, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Aluminum impairs liver transport function which is counteracted by vitamin E.Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2007 Jun ;116(3):329-48. PMID: 17709913

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Cholestasis, Lipid Peroxidation, Oxidative Stress

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum

[+]

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2006 Nov 14 ;12(42):6835-41. PMID: 17106933

Article Published Date : Nov 13, 2006

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Cholestasis, Liver Cirrhosis, Oxidative Stress

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Antitumor effect of ginsenoside Rg3 on gallbladder cancer.Oct 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2018 Nov ;16(5):5687-5696. Epub 2018 Aug 20. PMID: 30344724

Article Published Date : Oct 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Artemisinin may be suitable for the treatment of gallbladder cancer.Mar 29, 2016

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27035431

Article Published Date : Mar 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Artemisinin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1.Jan 07, 2020

Click here to read the entire abstract

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2020 Jan 8. Epub 2020 Jan 8. PMID: 31915810

Article Published Date : Jan 07, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Both excessive ascorbic acid intake and deficiency lower biliary cholesterol saturation and bile synthesis. Mar 01, 1981

Click here to read the entire abstract

Pubmed Data : J Nutr. 1981 Mar;111(3):412-24. PMID: 7205399

Article Published Date : Mar 01, 1981

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Cholestasis, Gallstones

[+]

Casein (cow's milk protein) consumption may be associated with gallstone formation. Nov 01, 1979

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 1979 Nov;32(11):2174-6. PMID: 573964

Article Published Date : Nov 01, 1979

Study Type : Animal Study

Additional Links

Diseases : Gallstones

Additional Keywords : Casein-Free Diet

[+]

Curcumin and capsaicin inhibit biliary cholesterol crystal nucleation in rats. Oct 01, 1994

Click here to read the entire abstract

Pubmed Data : Indian J Biochem Biophys. 1994 Oct;31(5):407-12. PMID: 7851942

Article Published Date : Oct 01, 1994

Study Type : Animal Study

Additional Links

Substances : Cayenne, Curcumin

Diseases : Cholestasis

[+]

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lipids Health Dis. 2015 ;14(1):100. Epub 2015 Sep 3. PMID: 26335572

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Gallstones, High Fat Diet

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

[+]

Curcumin prevents and reverses cirrhosis induced by bile duct obstruction.Aug 01, 2008

Click here to read the entire abstract

Pubmed Data : Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. PMID: 18705752

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Biliary Cirrhosis, Cirrhosis, Gallbladder Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Curcumin reduces gallstone formation and biliary cholesterol concentration in mice. Oct 01, 1992

Click here to read the entire abstract

Pubmed Data : Indian J Med Res. 1992 Oct;96:288-91. PMID: 1459671

Article Published Date : Oct 01, 1992

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cholestasis, Gallstones

[+]

Curcumin treatment has a protective effect against intestinal damage induced by bile duct ligation.Dec 17, 2015

Click here to read the entire abstract

Pubmed Data : J Invest Surg. 2015 Dec 18:1-9. Epub 2015 Dec 18. PMID: 26682581

Article Published Date : Dec 17, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cholestasis

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Gastroprotective

[+]

Diakon radish has antioxidant and choleretic properties.Dec 27, 2006

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2006 Dec 27;54(26):9773-8. PMID: 17177500

Article Published Date : Dec 27, 2006

Study Type : Animal Study

Additional Links

Substances : Daikon radish

Diseases : Biliary Tract Diseases, Cholestasis

Pharmacological Actions : Antioxidants, Cholagogues and Choleretics

Additional Keywords : Plant Extracts

[+]

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice.Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2009 Sep;87(9):684-93. PMID: 19794519

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Fenugreek

Diseases : Gallstones

[+]

Dietary garlic and onion reduce the incidence of diet-induced cholesterol gallstones in mice. Oct 01, 2003

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2003 Oct;58(10):753-5. PMID: 18983715

Article Published Date : Oct 01, 2003

Study Type : Animal Study

Additional Links

Substances : Garlic, Onion

Diseases : Gallstones

[+]

Dietary garlic and onion regresses preestablished cholesterol gallstones in experimental mice. Feb 10, 2010

Click here to read the entire abstract

Pubmed Data : Metabolism. 2010 Feb 10. Epub 2010 Feb 10. PMID: 20153000

Article Published Date : Feb 10, 2010

Study Type : Animal Study

Additional Links

Substances : Garlic, Onion

Diseases : Gallstones

Additional Keywords : Disease Regression

[+]

Dietary rosmarinic acid supplementation may be beneficial in terms of improving cholestasis-related liver injury.Aug 04, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Aug 5 ;108(Pt A):214-223. Epub 2017 Aug 5. PMID: 28789951

Article Published Date : Aug 04, 2017

Study Type : Animal Study

Additional Links

Substances : Rosmarinic acid

Diseases : Cholestasis, Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor

[+]

EGCG reduces the susceptibility to cholesterol gallstone formation through the regulation of inflammation.Dec 01, 2008

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2008 Dec;62(10):677-83. Epub 2008 Jan 30. PMID: 18374538

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Cholecystitis, Gallbladder Inflammation, Gallstones

[+]

EPA prevents the formation of cholesterol gallstones in an animal model. Oct 01, 1997

Click here to read the entire abstract

Pubmed Data : Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:50P-55P. PMID: 9503405

Article Published Date : Oct 01, 1997

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Cholestasis, Gallstones

[+]

Fish oil inhibits cholesterol crystallization and gallstone formation in an animal model. Sep 01, 1995

Click here to read the entire abstract

Pubmed Data : Surgery. 1995 Sep;118(3):517-23. PMID: 7652688

Article Published Date : Sep 01, 1995

Study Type : Animal Study

Additional Links

Substances : Fish Oil

Diseases : Cholestasis, Gallstones

[+]

Garlic and onion have anti-lithogenic activity in formation of cholesterol gallstones. Jan 14, 2010

Click here to read the entire abstract

Pubmed Data : Steroids. 2010 Jan 14. Epub 2010 Jan 14. PMID: 20079366

Article Published Date : Jan 14, 2010

Study Type : Animal Study

Additional Links

Substances : Garlic, Onion

Diseases : Gallstones

[+]

Ginsenosides restore lipid and redox homeostasis in mice with intrahepatic cholestasis.Sep 21, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Sep 22 ;14(19). Epub 2022 Sep 22. PMID: 36235592

Article Published Date : Sep 21, 2022

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Cholestasis

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic, Nrf2 activation

[+]

L. tridentata (chaparral) significantly reduces gallstone formation and gallbladder bile cholesterol concentration.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2005 Sep;57(9):1093-9. PMID: 16105230

Article Published Date : Sep 01, 2005

Study Type : Animal Study

Additional Links

Substances : Chaparral

Diseases : Gallstones

[+]

Lycopene might have protective effects on acute cholestasis.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Turk J Med Sci. 2015 ;45(4):857-64. PMID: 26422858

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Cholestasis

Pharmacological Actions : Hepatoprotective

[+]

Nigella sativa exerts a therapeutic effect on cholestatic liver injury in bile duct ligated rats.Dec 31, 2009

Click here to read the entire abstract

Pubmed Data : Cell Biochem Funct. 2010 Jan ;28(1):83-8. PMID: 20029957

Article Published Date : Dec 31, 2009

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Cholestasis, Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Norcantharidin, a compound found within the traditional Chinese medicine Mylabris, has an anti-angiogenic activity in human gallbladder cancer cells.Mar 14, 2006

Click here to read the entire abstract

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2006 Mar 14;86(10):693-9. PMID: 16681930

Article Published Date : Mar 14, 2006

Study Type : Animal Study

Additional Links

Substances : Traditional Chinese Medicine: Mylabris

Diseases : Gallbladder Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Apoptotic, Vascular Endothelial Growth Factor A Inhibitor

Additional Keywords : Drug: 5-flourouracil

[+]

Nrf2-dependent protective effect of paeoniflorin on α-naphthalene isothiocyanate-induced hepatic injury.Dec 31, 2021

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2022 ;50(5):1331-1348. Epub 2022 Jun 22. PMID: 35729506

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Isothiocyanates, Paeoniflorin

Diseases : Chemically-Induced Liver Damage, Cholestasis

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Isothiocyanates

[+]

Paeonia lactiflora regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2018 Dec ;70(12):1675-1687. Epub 2018 Sep 14. PMID: 30277564

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Peony

Diseases : Cholestasis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Paeoniae Radix Rubra can enhance fatty acid β-oxidation and alleviate gut microbiota disorder.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:1002922. Epub 2022 Oct 21. PMID: 36339580

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Peony

Diseases : Cholestasis

Pharmacological Actions : Gastrointestinal Agents

[+]

Psyllium fiber has a unique effect on cholesterol plasma removal and excretion.Jun 01, 1998

Click here to read the entire abstract

Pubmed Data : Lipids. 1998 Jun;33(6):573-82. PMID: 9655372

Article Published Date : Jun 01, 1998

Study Type : Animal Study

Additional Links

Substances : Psyllium

Diseases : Cholestasis, Cholesterol: High

Pharmacological Actions : Cholagogues and Choleretics

[+]

Psyllium protects against cholesterol gallstone formation.Apr 01, 1999

Click here to read the entire abstract

Pubmed Data : Am J Surg. 1999 Apr;177(4):307-10 PMID: 10326849

Article Published Date : Apr 01, 1999

Study Type : Animal Study

Additional Links

Substances : Psyllium

Diseases : Gallstones

[+]

R-alpha-lipoic acid inhibits glucose production and stimulates bile flow in the rat liver.Aug 01, 2002

Click here to read the entire abstract

Pubmed Data : Liver. 2002 Aug;22(4):355-62. PMID: 12296970

Article Published Date : Aug 01, 2002

Study Type : Animal Study

Additional Links

Substances : R-alpha lipoic acid

Diseases : Cholestasis, Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Cholagogues and Choleretics, Gluconeogenesis Inhibitor

[+]

Red yeast increases excretion of bile acids in hamsters.Aug 01, 2009

Click here to read the entire abstract

Pubmed Data : Biomed Environ Sci. 2009 Aug;22(4):269-77. PMID: 19950521

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Red Yeast Rice

Diseases : Cholestasis

Pharmacological Actions : Cholagogues and Choleretics

[+]

Shikonin induces apoptosis and G0/G1 phase arrest of gallbladder cancer cells.Nov 30, 2017

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2017 Dec ;38(6):3473-3480. Epub 2017 Oct 17. PMID: 29039581

Article Published Date : Nov 30, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Dose Response

[+]

Silymarin increases hepatoprotective biliary bile sale secretion in the rat. Apr 15, 2000

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2000 Apr 15;59(8):1015-22. PMID: 10692567

Article Published Date : Apr 15, 2000

Study Type : Animal Study

Additional Links

Substances : Milk Thistle

Diseases : Cholestasis

Pharmacological Actions : Hepatoprotective

[+]

Silymarin protects the liver from α-naphthylisothiocyanate-induced cholestasis.Jul 30, 2022

Click here to read the entire abstract

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2022 Jul 31 ;68(7):208-212. Epub 2022 Jul 31. PMID: 36495494

Article Published Date : Jul 30, 2022

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Cholestasis

Pharmacological Actions : Hepatoprotective

Additional Keywords : Gene Expression Regulation

[+]

Silymarin, a compound found within milk thistle seed, prevents estrogen-induced cholestasis in the rats. Aug 01, 2001

Click here to read the entire abstract

Pubmed Data : Hepatology. 2001 Aug;34(2):329-39. PMID: 11481618

Article Published Date : Aug 01, 2001

Study Type : Animal Study

Additional Links

Substances : Milk Thistle

Diseases : Cholestasis, Estrogen-Induced Cholestasis

[+]

Statin drug induced myopathy is amplified in the rats administered cyclcosporine A. Jun 01, 1991

Click here to read the entire abstract

Pubmed Data : J Pharmacol Exp Ther. 1991 Jun;257(3):1225-35. PMID: 1904494

Article Published Date : Jun 01, 1991

Study Type : Animal Study

Additional Links

Diseases : Cholestasis, Drug-Induced Toxicity , Myopathies, Organ Transplantation, Statin-Induced Pathologies

Problem Substances : Cyclosporins, Simvastatin, Statin Drugs

[+]

Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells.Feb 28, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Braz J Med Biol Res. 2018 Mar 1 ;51(4):e6891. Epub 2018 Mar 1. PMID: 29513793

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Polyphenols

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Antiproliferative, Apoptotic, Cell cycle arrest, Gallbladder Cancer, POLYPHENOLS

[+]

The effect of ellagic acid on intra-abdominal adhesions caused by gallstones.Nov 09, 2021

Click here to read the entire abstract

Pubmed Data : Surg Laparosc Endosc Percutan Tech. 2021 Nov 10 ;32(2):166-171. Epub 2021 Nov 10. PMID: 34753896

Article Published Date : Nov 09, 2021

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Gallstones

Pharmacological Actions : Gastrointestinal Agents

[+]

The present study demonstrated the synergistic effects of RGHP in ANIT-induced cholestatic rats at pharmacodynamic and pharmacokinetic levels.Sep 12, 2015

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2015 Sep 13. Epub 2015 Sep 13. PMID: 26376237

Article Published Date : Sep 12, 2015

Study Type : Animal Study

Additional Links

Substances : Gardenia, Rhubarb

Diseases : Cholestasis

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

The results of this study suggest that magnesium sulfate treatment may be beneficial in cholestasis induced hepatotoxicity. Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Magnes Res. 2015 Feb 1 ;28(1):32-45. PMID: 25967882

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Magnesium Sulfate

Diseases : Cholestasis

Pharmacological Actions : Cholagogues and Choleretics, Hepatoprotective

[+]

Thymoquinone can be used as a liver protectant in patients with cholestasis. Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Genet Mol Res. 2015 ;14(4):12247-53. Epub 2015 Oct 9. PMID: 26505373

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Cholestasis

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2014 ;14(1):96. Epub 2014 Oct 29. PMID: 25383044

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

Additional Keywords : Dose Response

[+]

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2015 ;9:3969-87. Epub 2015 Aug 10. PMID: 26309394

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Gallbladder Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

A compound from the traditional Chinese medicine inhibits the growth of human gallbladder cells.Feb 01, 2007

Click here to read the entire abstract

Pubmed Data : Hepatobiliary Pancreat Dis Int. 2007 Feb;6(1):72-80. PMID: 17287171

Article Published Date : Feb 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Traditional Chinese Medicine: Mylabris

Diseases : Gallbladder Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway.Apr 30, 2017

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2017 May ;39(5):1010428317698359. PMID: 28459363

Article Published Date : Apr 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Arctigenin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Artemisinin inhibits proliferation of gallbladder cancer cell lines.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : Zhonghua Wai Ke Za Zhi. 2016 Mar 1 ;54(3):222-7. PMID: 26932893

Article Published Date : Feb 29, 2016

Study Type : In Vitro Study

Additional Links

Substances : Artemisinin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Curcumin reduces the programmed cell death associated with toxic bile acids in liver injury during cholestasis. Feb 17, 2006

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2006 Feb 17;340(3):800-6. Epub 2005 Dec 20. PMID: 16380075

Article Published Date : Feb 17, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cholestasis

Pharmacological Actions : Apoptotic, Enzyme Inhibitors, Hepatoprotective

[+]

Emodin enhances sensitivity of gallbladder cancer cells to chemotherapy.Apr 15, 2010

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2010 Apr 15;79(8):1134-40. Epub 2009 Dec 11. PMID: 20005210

Article Published Date : Apr 15, 2010

Study Type : In Vitro Study

Additional Links

Substances : Emodin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Gallbladder Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

Garlic oil is more effective than monoctanoin in dissolving gallstones. Oct 01, 2000

Click here to read the entire abstract

Pubmed Data : Trop Gastroenterol. 2000 Oct-Dec;21(4):177-9. PMID: 11194578

Article Published Date : Oct 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Garlic

Diseases : Gallstones

Additional Keywords : Food as Medicine, Superiority of Natural Substances versus Drugs

[+]

Genistein suppresses the proliferative activity in Src-activated human gallbladder carcinoma cells.Jul 23, 2020

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2020 Jul 24:1-9. Epub 2020 Jul 24. PMID: 32705888

Article Published Date : Jul 23, 2020

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

Hesperidin can be considered as a potential anticancerous compound for the treatment of gall bladder carcinoma.Sep 27, 2018

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2018 Sep 28:1-12. Epub 2018 Sep 28. PMID: 30265812

Article Published Date : Sep 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Isorhamnetin Inhibits human gallbladder cancer cell proliferation and metastasis.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:628621. Epub 2021 Feb 17. PMID: 33679411

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Sea buckthorn

Diseases : Gallbladder Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Lecithin may play a therapeutic role in preventing and treating gallstones. Jul 01, 1984

Click here to read the entire abstract

Pubmed Data : Ann Clin Lab Sci. 1984 Jul-Aug;14(4):243-51. PMID: 6380394

Article Published Date : Jul 01, 1984

Study Type : Commentary

Additional Links

Substances : Lecithin

Diseases : Gallstones

[+]

Long-term exposure to genistein inhibits the proliferation of gallbladder cancer.Apr 29, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Bull (Beijing). 2022 Apr 30 ;67(8):813-824. Epub 2022 Jan 17. PMID: 36546234

Article Published Date : Apr 29, 2022

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative

[+]

Low levels of vitamin C (ascorbic acid) may contribute to the formation of cholesterol gallstones. Feb 01, 1993

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 1993 Feb;40(2):81-4. PMID: 8455479

Article Published Date : Feb 01, 1993

Study Type : Review

Additional Links

Substances : Vitamin C

Diseases : Gallstones

[+]

Magnesium consumption reduces gallstone risk - Article 2Feb 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2008 Feb;103(2):383-5. PMID: 18289201

Article Published Date : Feb 01, 2008

Study Type : Commentary

Additional Links

Substances : Magnesium

Diseases : Gallstones

[+]

Melatonin may be therapeutic in gallstones and gallbladder inflammation. Oct 01, 2008

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2008 Oct;53(10):2592-603. Epub 2008 Mar 13. PMID: 18338264

Article Published Date : Oct 01, 2008

Study Type : Commentary

Additional Links

Substances : Melatonin

Diseases : Gallbladder Inflammation, Gallstones

[+]

Norcantharidin, a compound found within the traditional Chinese medicine Mylabris, inhibits the proliferation and invasion of human gallbladder cancer cells.Apr 28, 2005

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2005 Apr 28;11(16):2431-7. PMID: 15832413

Article Published Date : Apr 28, 2005

Study Type : In Vitro Study

Additional Links

Substances : Traditional Chinese Medicine: Mylabris

Diseases : Cancer Metastasis, Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Oridonin inhibits hypoxia-induced epithelial-mesenchymal transition and cell migration in gallbladder cancer.Jan 09, 2019

Click here to read the entire abstract

Pubmed Data : Anticancer Drugs. 2019 10 ;30(9):925-932. PMID: 31517732

Article Published Date : Jan 09, 2019

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Gallbladder Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Exp Med. 2015 ;8(10):17781-8. Epub 2015 Oct 15. PMID: 26770369

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Gallbladder Cancer

Pharmacological Actions : Chemopreventive

[+]

Peppermint oil stimulates bile fluid secretion and thus has a choleretic effect.Jul 31, 2011

Click here to read the entire abstract

Pubmed Data : J Dig Dis. 2011 Aug ;12(4):295-301. PMID: 21791024

Article Published Date : Jul 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Peppermint

Diseases : Cholestasis

Pharmacological Actions : Cholagogues and Choleretics

[+]

Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway.Aug 22, 2019

Click here to read the entire abstract

Pubmed Data : Int J Mol Med. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31485612

Article Published Date : Aug 22, 2019

Study Type : In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Cholangiocarcinoma, Gallbladder Cancer

Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic

[+]

Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway.Feb 22, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Feb 23 ;11(1):4391. Epub 2021 Feb 23. PMID: 33623100

Article Published Date : Feb 22, 2021

Study Type : In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Resveratrol suppresses gallbladder cancer cells.Jun 01, 2005

Click here to read the entire abstract

Pubmed Data : Zhong Yao Cai. 2005 Jun;28(6):489-91. PMID: 16209266

Article Published Date : Jun 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Stilbenes

[+]

Schisandrol B protects against cholestatic liver injury through pregnane X receptors.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Pharmacol. 2017 04 ;174(8):672-688. Epub 2017 Mar 16. PMID: 28128437

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Cholestasis, Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Silymarin has anticholestatic properities which may be of value in the treatment of gallstone formation. Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Curr Med Chem. 2006;13(9):1055-74. PMID: 16611084

Article Published Date : Jan 01, 2006

Study Type : Review

Additional Links

Substances : Milk Thistle

Diseases : Cholestasis, Gallstones

[+]

Sinensetin flavone has the potential to be developed as a candidate treatment against gallbladder adenocarcinoma.Feb 29, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J BUON. 2020 Mar-Apr;25(2):1251-1256. PMID: 32521933

Article Published Date : Feb 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Gallbladder Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage.Jun 01, 2008

Click here to read the entire abstract

Pubmed Data : Nutr Res. 2008 Jun;28(6):351-7. PMID: 19083431

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Fiber, Green Leafy Vegetables

Diseases : Cholestasis, High Cholesterol

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Raw versus Cooked

[+]

These spices prevent the induction of cholesterol gallstones by lithogenic high cholesterol diet and also regress the pre-established cholesterol gallstones.Jul 05, 2015

Click here to read the entire abstract

Pubmed Data : Crit Rev Food Sci Nutr. 2015 Jul 6:0. Epub 2015 Jul 6. PMID: 26147513

Article Published Date : Jul 05, 2015

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Curcumin, Fenugreek, Garlic, Onions, Turmeric

Diseases : Gallstones

Pharmacological Actions : Hypolipidemic

Additional Keywords : Hypocholesterolemic Spices

[+]

Ursolic acid induces apoptosis and inhibits invasion of GBC-SD gallbladder carcinoma cells.Jul 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2019 Aug ;18(2):1467-1474. Epub 2019 May 27. PMID: 31423212

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Gallbladder Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic

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View the Evidence: 116 Abstracts with Gallbladder Disease Research

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Expectant management (i.e. doing nothing) of gallstone disease is a valid therapeutic approach in the majority of patients.Apr 01, 2010

This study suggests vegetables and fruits consumption is correlated with a significantly reduced risk of gallstone disease.Jun 30, 2019

A diet rich in refined carbohydrate increases bile cholesterol saturation and consequently gallstone formation. Jan 01, 1983

A vegetarian diet is correlated with significantly decreased risk for gallstones in women. Sep 01, 2003

Celiac disease has a high prevalance rate in autoimmune cholestatic liver disorders.Oct 01, 2002

Chelidonium and turmeric root extract have a therapeutic effect on upper abdominal pain due to functional disorders of the biliary system. Aug 15, 1999

Curcumin has a contractive effect on human gallbladder function.Jan 01, 2006

Curcumin has gall-bladder emptying properties. Jan 01, 2002

Dietary fiber protected against acute pancreatitis related and unrelated to gallstones, while coffees protection was unrelated to gallstones. Sep 04, 2016

Fish oil fatty acids reduce the cholesterol saturation index and nucleation time in obese subjects, which probably result in prevention of gallstone formation. Nov 01, 2009

Frequent nut consumption decreases the risk of cholecystectomy in women.Jul 01, 2004

Frequent nut consumption is associated with a reduced risk of gallstone disease in men.Nov 15, 2004

High consumption of sweetened beverages may increase the risk of biliary tract cancer and gallbladder cancer.Sep 30, 2016

High inake of fried food and constipation are associated with increased risk of bile duct and gallbladder cancer. The consumption of boiled beans and fish may reduce the risk.Jun 01, 2005

Increased fruit and vegetable consumption may decrease a risk of extrahepatic bile duct cancer.Oct 30, 2016

Laser reflex therapy improves patients with chronic acalculous cholecystitis (biliary dyskinesia) Jan 01, 2009

Lecithin contributes to gallstone dissolution or reduction in size, as well as reducing the lithogenic index of bile. Dec 06, 1975

Low antioxidant levels, impaired glutathione reserve in the liver, and low levels of sulphur amino acids are associated with the development of gallstones. Nov 01, 2004

Magnesium consumption has a protective role in prevention of symptomatic gallstone disease among men. Feb 01, 2008

Moderate tea drinking decreased the associated risk of gallstones in a Taiwanese population.Aug 21, 2018

Omega-3 fatty acids prevent the formation of urinary calcium oxalate stone formation.Feb 01, 2011

Patients with pre-operative dyspeptic symptoms, notably bad taste and flatulence, have an increased risk of negative post-cholecystectomy outcomes at 6 weeks. Feb 01, 2009

Resveratrol could be a potential therapeutic target for intrahepatic cholestasis of pregnancy.May 31, 2018

Tea consumption reduces the risk of biliary tract and gallbladder diseases.Nov 01, 2005

The consumption of fruits and vegetables has a protective effect against the development of bladder cancer.Aug 01, 2002

The leaf juice of S. grandiflora demonstrates significant antiurolithiatic activity against calcium oxalate-type stones. Jul 01, 2008

The risk of gallbladder cancer is inversely related to the level of vegetable consumption. Apr 01, 2006

This is the first study to discover a potential association of the gut microbiota dysbiosis that is present among gallstone patients.Sep 30, 2013

Ursodeoxycholic acid has been reported to ameliorate cholestatic hepatitis induced by high levels of vitamin A. Oct 01, 2007

Vitamin D deficiency is associated with gallbladder stasis and gallstones. May 11, 2015

Vitamin D might have an impact on gallstone disease. Sep 30, 2016

Wheat bran consumption prevents cholesterol gallstones. Aug 24, 1984

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported.Jan 01, 2010

A homeopathic approach to treat patients with advanced gallbladder, periampullary, and liver carcinomas.Jan 31, 2012

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Cholestatic jaundice during lovastatin medication has been reported. May 10, 1991

Lovastatin-induced cholestasis has been reported. Feb 01, 1993

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

Oroxylin A exerts its antitumor effects in human gallbladder cancer.Dec 31, 2019

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Aluminum impairs liver transport function which is counteracted by vitamin E.Jun 01, 2007

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Antitumor effect of ginsenoside Rg3 on gallbladder cancer.Oct 31, 2018

Artemisinin may be suitable for the treatment of gallbladder cancer.Mar 29, 2016

Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1.Jan 07, 2020

Both excessive ascorbic acid intake and deficiency lower biliary cholesterol saturation and bile synthesis. Mar 01, 1981

Casein (cow's milk protein) consumption may be associated with gallstone formation. Nov 01, 1979

Curcumin and capsaicin inhibit biliary cholesterol crystal nucleation in rats. Oct 01, 1994

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin prevents and reverses cirrhosis induced by bile duct obstruction.Aug 01, 2008

Curcumin reduces gallstone formation and biliary cholesterol concentration in mice. Oct 01, 1992

Curcumin treatment has a protective effect against intestinal damage induced by bile duct ligation.Dec 17, 2015

Diakon radish has antioxidant and choleretic properties.Dec 27, 2006

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice.Sep 01, 2009

Dietary garlic and onion reduce the incidence of diet-induced cholesterol gallstones in mice. Oct 01, 2003

Dietary garlic and onion regresses preestablished cholesterol gallstones in experimental mice. Feb 10, 2010

Dietary rosmarinic acid supplementation may be beneficial in terms of improving cholestasis-related liver injury.Aug 04, 2017

EGCG reduces the susceptibility to cholesterol gallstone formation through the regulation of inflammation.Dec 01, 2008

EPA prevents the formation of cholesterol gallstones in an animal model. Oct 01, 1997

Fish oil inhibits cholesterol crystallization and gallstone formation in an animal model. Sep 01, 1995

Garlic and onion have anti-lithogenic activity in formation of cholesterol gallstones. Jan 14, 2010

Ginsenosides restore lipid and redox homeostasis in mice with intrahepatic cholestasis.Sep 21, 2022

L. tridentata (chaparral) significantly reduces gallstone formation and gallbladder bile cholesterol concentration.Sep 01, 2005

Lycopene might have protective effects on acute cholestasis.Dec 31, 2014

Nigella sativa exerts a therapeutic effect on cholestatic liver injury in bile duct ligated rats.Dec 31, 2009

Norcantharidin, a compound found within the traditional Chinese medicine Mylabris, has an anti-angiogenic activity in human gallbladder cancer cells.Mar 14, 2006

Nrf2-dependent protective effect of paeoniflorin on α-naphthalene isothiocyanate-induced hepatic injury.Dec 31, 2021

Paeonia lactiflora regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis.Nov 30, 2018

Gallbladder Disease

View the Evidence:
116 Abstracts with Gallbladder Disease Research