Gallstones

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31 Substances Researched for Gallstones

Name	AC	CK
Fiber	2	20
Fruit: All	1	20
Nuts	2	20
Peanut	2	20
Vegetables: All	1	20
Vitamin D	2	20
EPA (Eicosapentaenoic Acid)	2	12
Fish Oil	2	12
Lecithin	2	11
Magnesium	2	11
Black Tea	1	10
Coffee	1	10
DHA (Docosahexaenoic Acid)	1	10
Green Tea	1	10
Omega-3 Fatty Acids	1	10
Sesbania grandiflora	1	10
Wheat Bran	1	10
Garlic	5	8
Onion	3	6
Curcumin	3	5
Fenugreek	2	3
Vitamin C	2	3
Chaparral	1	2
EGCG (Epigallocatechin gallate)	1	2
Piperine	1	2
Psyllium	1	2
Capsaicin	1	1
Melatonin	1	1
Milk Thistle	1	1
Onions	1	1
Turmeric	1	1

2 Therapeutic Actions Researched for Gallstones

Name	AC	CK	Focus
Doing Nothing	1	20
Watchful Waiting	1	20

1 Problematic Actions Researched for Gallstones

Name	AC	CK	Focus
Surgical Procedures	1	20

Research Articles 38
Cumulative Knowledge Score 61
Overall Research Rating GOOD

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View the Evidence:
39 Abstracts with Gallstones Research

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[+]

Expectant management (i.e. doing nothing) of gallstone disease is a valid therapeutic approach in the majority of patients.Apr 01, 2010

Click here to read the entire abstract

Pubmed Data : J Gastroenterol Hepatol. 2010 Apr;25(4):719-24. PMID: 20492328

Article Published Date : Apr 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Cholecystectomy, Gallbladder Surgery: Removal, Gallstones

Therapeutic Actions : Doing Nothing, Watchful Waiting

Anti Therapeutic Actions : Surgical Procedures

[+]

This study suggests vegetables and fruits consumption is correlated with a significantly reduced risk of gallstone disease.Jun 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2019 Jul ;98(28):e16404. PMID: 31305451

Article Published Date : Jun 30, 2019

Study Type : Meta Analysis, Review

Additional Links

Substances : Fruit: All, Vegetables: All

Diseases : Gallstones

Additional Keywords : Risk Reduction

[+]

A diet rich in refined carbohydrate increases bile cholesterol saturation and consequently gallstone formation. Jan 01, 1983

Click here to read the entire abstract

Pubmed Data : Gut. 1983 Jan;24(1):2-6. PMID: 6293939

Article Published Date : Jan 01, 1983

Study Type : Human Study

Additional Links

Diseases : Gallstones

Additional Keywords : Refined Carbohydrate Diet

[+]

A vegetarian diet is correlated with significantly decreased risk for gallstones in women. Sep 01, 2003

Click here to read the entire abstract

Pubmed Data : Indian J Med Sci. 2003 Sep;57(9):387-93. PMID: 3926039

Article Published Date : Sep 01, 2003

Study Type : Human Study

Additional Links

Diseases : Gallstones

[+]

Dietary fiber protected against acute pancreatitis related and unrelated to gallstones, while coffees protection was unrelated to gallstones. Sep 04, 2016

Click here to read the entire abstract

Pubmed Data : Clin Gastroenterol Hepatol. 2016 Sep 5. Epub 2016 Aug 5. PMID: 27609706

Article Published Date : Sep 04, 2016

Study Type : Human Study

Additional Links

Substances : Coffee, Fiber

Diseases : Gallstones, Pancreatitis

Additional Keywords : Risk Reduction

[+]

Fish oil fatty acids reduce the cholesterol saturation index and nucleation time in obese subjects, which probably result in prevention of gallstone formation. Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : Appl Ergon. 2009 Nov;40(6):1047-54. Epub 2009 Jun 21. PMID: 11533270

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Substances : Fish Oil

Diseases : Gallstones

[+]

Frequent nut consumption decreases the risk of cholecystectomy in women.Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2004 Jul;80(1):76-81. PMID: 15213031

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : Nuts, Peanut

Diseases : Cholecystitis, Gallbladder Inflammation, Gallstones

[+]

Frequent nut consumption is associated with a reduced risk of gallstone disease in men.Nov 15, 2004

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2004 Nov 15;160(10):961-8. PMID: 15522852

Article Published Date : Nov 15, 2004

Study Type : Human Study

Additional Links

Substances : Nuts, Peanut

Diseases : Gallstones

[+]

Lecithin contributes to gallstone dissolution or reduction in size, as well as reducing the lithogenic index of bile. Dec 06, 1975

Click here to read the entire abstract

Pubmed Data : Lancet. 1975 Dec 6;2(7945):1124-6. PMID: 53604

Article Published Date : Dec 06, 1975

Study Type : Human Study

Additional Links

Substances : Lecithin

Diseases : Cholestasis, Gallstones

[+]

Low antioxidant levels, impaired glutathione reserve in the liver, and low levels of sulphur amino acids are associated with the development of gallstones. Nov 01, 2004

Click here to read the entire abstract

Pubmed Data : Clin Chim Acta. 2004 Nov;349(1-2):157-65. PMID: 15469869

Article Published Date : Nov 01, 2004

Study Type : Human Study

Additional Links

Diseases : Gallstones

[+]

Magnesium consumption has a protective role in prevention of symptomatic gallstone disease among men. Feb 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2008 Feb;103(2):375-82. Epub 2007 Dec 12. PMID: 18076730

Article Published Date : Feb 01, 2008

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Gallstones

[+]

Moderate tea drinking decreased the associated risk of gallstones in a Taiwanese population.Aug 21, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Clin Nutr. 2018 Aug 22. Epub 2018 Aug 22. PMID: 30135551

Article Published Date : Aug 21, 2018

Study Type : Human Study

Additional Links

Substances : Black Tea, Green Tea

Diseases : Gallstones

Additional Keywords : Risk Reduction

[+]

Omega-3 fatty acids prevent the formation of urinary calcium oxalate stone formation.Feb 01, 2011

Click here to read the entire abstract

Pubmed Data : J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 21168878

Article Published Date : Feb 01, 2011

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Bladder Stones, Gallstones, Kidney Stones

[+]

The leaf juice of S. grandiflora demonstrates significant antiurolithiatic activity against calcium oxalate-type stones. Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Nat Med (Tokyo). 2008 Jul;62(3):300-7. Epub 2008 Apr 12. PMID: 18408896

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Sesbania grandiflora

Diseases : Gallstones, Kidney Stones

Pharmacological Actions : Antiurolithiatic

[+]

This is the first study to discover a potential association of the gut microbiota dysbiosis that is present among gallstone patients.Sep 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Genomics. 2013 Oct 1 ;14:669. Epub 2013 Oct 1. PMID: 24083370

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Diseases : Dysbiosis, Gallstones

Additional Keywords : Microbiota

[+]

Vitamin D deficiency is associated with gallbladder stasis and gallstones. May 11, 2015

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2015 May 12. Epub 2015 May 12. PMID: 25963323

Article Published Date : May 11, 2015

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Gallstones, Vitamin D Deficiency

Additional Keywords : Increased Risk, Risk Reduction

[+]

Vitamin D might have an impact on gallstone disease. Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Endocrine. 2016 Oct 1. Epub 2016 Aug 1. PMID: 27696253

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Gallstones, Vitamin D Deficiency

Additional Keywords : Risk Reduction

[+]

Wheat bran consumption prevents cholesterol gallstones. Aug 24, 1984

Click here to read the entire abstract

Pubmed Data : Dtsch Med Wochenschr. 1984 Aug 24;109(34):1284-8. PMID: 6088204

Article Published Date : Aug 24, 1984

Study Type : Human Study

Additional Links

Substances : Fiber, Wheat Bran

Diseases : Gallstones

[+]

Both excessive ascorbic acid intake and deficiency lower biliary cholesterol saturation and bile synthesis. Mar 01, 1981

Click here to read the entire abstract

Pubmed Data : J Nutr. 1981 Mar;111(3):412-24. PMID: 7205399

Article Published Date : Mar 01, 1981

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Cholestasis, Gallstones

[+]

Casein (cow's milk protein) consumption may be associated with gallstone formation. Nov 01, 1979

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 1979 Nov;32(11):2174-6. PMID: 573964

Article Published Date : Nov 01, 1979

Study Type : Animal Study

Additional Links

Diseases : Gallstones

Additional Keywords : Casein-Free Diet

[+]

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lipids Health Dis. 2015 ;14(1):100. Epub 2015 Sep 3. PMID: 26335572

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Gallstones, High Fat Diet

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

[+]

Curcumin reduces gallstone formation and biliary cholesterol concentration in mice. Oct 01, 1992

Click here to read the entire abstract

Pubmed Data : Indian J Med Res. 1992 Oct;96:288-91. PMID: 1459671

Article Published Date : Oct 01, 1992

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cholestasis, Gallstones

[+]

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice.Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2009 Sep;87(9):684-93. PMID: 19794519

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Fenugreek

Diseases : Gallstones

[+]

Dietary garlic and onion reduce the incidence of diet-induced cholesterol gallstones in mice. Oct 01, 2003

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2003 Oct;58(10):753-5. PMID: 18983715

Article Published Date : Oct 01, 2003

Study Type : Animal Study

Additional Links

Substances : Garlic, Onion

Diseases : Gallstones

[+]

Dietary garlic and onion regresses preestablished cholesterol gallstones in experimental mice. Feb 10, 2010

Click here to read the entire abstract

Pubmed Data : Metabolism. 2010 Feb 10. Epub 2010 Feb 10. PMID: 20153000

Article Published Date : Feb 10, 2010

Study Type : Animal Study

Additional Links

Substances : Garlic, Onion

Diseases : Gallstones

Additional Keywords : Disease Regression

[+]

EGCG reduces the susceptibility to cholesterol gallstone formation through the regulation of inflammation.Dec 01, 2008

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2008 Dec;62(10):677-83. Epub 2008 Jan 30. PMID: 18374538

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Cholecystitis, Gallbladder Inflammation, Gallstones

[+]

EPA prevents the formation of cholesterol gallstones in an animal model. Oct 01, 1997

Click here to read the entire abstract

Pubmed Data : Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:50P-55P. PMID: 9503405

Article Published Date : Oct 01, 1997

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Cholestasis, Gallstones

[+]

Fish oil inhibits cholesterol crystallization and gallstone formation in an animal model. Sep 01, 1995

Click here to read the entire abstract

Pubmed Data : Surgery. 1995 Sep;118(3):517-23. PMID: 7652688

Article Published Date : Sep 01, 1995

Study Type : Animal Study

Additional Links

Substances : Fish Oil

Diseases : Cholestasis, Gallstones

[+]

Garlic and onion have anti-lithogenic activity in formation of cholesterol gallstones. Jan 14, 2010

Click here to read the entire abstract

Pubmed Data : Steroids. 2010 Jan 14. Epub 2010 Jan 14. PMID: 20079366

Article Published Date : Jan 14, 2010

Study Type : Animal Study

Additional Links

Substances : Garlic, Onion

Diseases : Gallstones

[+]

L. tridentata (chaparral) significantly reduces gallstone formation and gallbladder bile cholesterol concentration.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2005 Sep;57(9):1093-9. PMID: 16105230

Article Published Date : Sep 01, 2005

Study Type : Animal Study

Additional Links

Substances : Chaparral

Diseases : Gallstones

[+]

Psyllium protects against cholesterol gallstone formation.Apr 01, 1999

Click here to read the entire abstract

Pubmed Data : Am J Surg. 1999 Apr;177(4):307-10 PMID: 10326849

Article Published Date : Apr 01, 1999

Study Type : Animal Study

Additional Links

Substances : Psyllium

Diseases : Gallstones

[+]

The effect of ellagic acid on intra-abdominal adhesions caused by gallstones.Nov 09, 2021

Click here to read the entire abstract

Pubmed Data : Surg Laparosc Endosc Percutan Tech. 2021 Nov 10 ;32(2):166-171. Epub 2021 Nov 10. PMID: 34753896

Article Published Date : Nov 09, 2021

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Gallstones

Pharmacological Actions : Gastrointestinal Agents

[+]

Garlic oil is more effective than monoctanoin in dissolving gallstones. Oct 01, 2000

Click here to read the entire abstract

Pubmed Data : Trop Gastroenterol. 2000 Oct-Dec;21(4):177-9. PMID: 11194578

Article Published Date : Oct 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Garlic

Diseases : Gallstones

Additional Keywords : Food as Medicine, Superiority of Natural Substances versus Drugs

[+]

Lecithin may play a therapeutic role in preventing and treating gallstones. Jul 01, 1984

Click here to read the entire abstract

Pubmed Data : Ann Clin Lab Sci. 1984 Jul-Aug;14(4):243-51. PMID: 6380394

Article Published Date : Jul 01, 1984

Study Type : Commentary

Additional Links

Substances : Lecithin

Diseases : Gallstones

[+]

Low levels of vitamin C (ascorbic acid) may contribute to the formation of cholesterol gallstones. Feb 01, 1993

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 1993 Feb;40(2):81-4. PMID: 8455479

Article Published Date : Feb 01, 1993

Study Type : Review

Additional Links

Substances : Vitamin C

Diseases : Gallstones

[+]

Magnesium consumption reduces gallstone risk - Article 2Feb 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2008 Feb;103(2):383-5. PMID: 18289201

Article Published Date : Feb 01, 2008

Study Type : Commentary

Additional Links

Substances : Magnesium

Diseases : Gallstones

[+]

Melatonin may be therapeutic in gallstones and gallbladder inflammation. Oct 01, 2008

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2008 Oct;53(10):2592-603. Epub 2008 Mar 13. PMID: 18338264

Article Published Date : Oct 01, 2008

Study Type : Commentary

Additional Links

Substances : Melatonin

Diseases : Gallbladder Inflammation, Gallstones

[+]

Silymarin has anticholestatic properities which may be of value in the treatment of gallstone formation. Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Curr Med Chem. 2006;13(9):1055-74. PMID: 16611084

Article Published Date : Jan 01, 2006

Study Type : Review

Additional Links

Substances : Milk Thistle

Diseases : Cholestasis, Gallstones

[+]

These spices prevent the induction of cholesterol gallstones by lithogenic high cholesterol diet and also regress the pre-established cholesterol gallstones.Jul 05, 2015

Click here to read the entire abstract

Pubmed Data : Crit Rev Food Sci Nutr. 2015 Jul 6:0. Epub 2015 Jul 6. PMID: 26147513

Article Published Date : Jul 05, 2015

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Curcumin, Fenugreek, Garlic, Onions, Turmeric

Diseases : Gallstones

Pharmacological Actions : Hypolipidemic

Additional Keywords : Hypocholesterolemic Spices

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Focus Your Research

Click any topic below to filter + focus research

Gallstones is a Sub of the following Topics

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View the Evidence: 39 Abstracts with Gallstones Research

Limited to Members Only

Currently Available Sorting Options

Expectant management (i.e. doing nothing) of gallstone disease is a valid therapeutic approach in the majority of patients.Apr 01, 2010

This study suggests vegetables and fruits consumption is correlated with a significantly reduced risk of gallstone disease.Jun 30, 2019

A diet rich in refined carbohydrate increases bile cholesterol saturation and consequently gallstone formation. Jan 01, 1983

A vegetarian diet is correlated with significantly decreased risk for gallstones in women. Sep 01, 2003

Dietary fiber protected against acute pancreatitis related and unrelated to gallstones, while coffees protection was unrelated to gallstones. Sep 04, 2016

Fish oil fatty acids reduce the cholesterol saturation index and nucleation time in obese subjects, which probably result in prevention of gallstone formation. Nov 01, 2009

Frequent nut consumption decreases the risk of cholecystectomy in women.Jul 01, 2004

Frequent nut consumption is associated with a reduced risk of gallstone disease in men.Nov 15, 2004

Lecithin contributes to gallstone dissolution or reduction in size, as well as reducing the lithogenic index of bile. Dec 06, 1975

Low antioxidant levels, impaired glutathione reserve in the liver, and low levels of sulphur amino acids are associated with the development of gallstones. Nov 01, 2004

Magnesium consumption has a protective role in prevention of symptomatic gallstone disease among men. Feb 01, 2008

Moderate tea drinking decreased the associated risk of gallstones in a Taiwanese population.Aug 21, 2018

Omega-3 fatty acids prevent the formation of urinary calcium oxalate stone formation.Feb 01, 2011

The leaf juice of S. grandiflora demonstrates significant antiurolithiatic activity against calcium oxalate-type stones. Jul 01, 2008

This is the first study to discover a potential association of the gut microbiota dysbiosis that is present among gallstone patients.Sep 30, 2013

Vitamin D deficiency is associated with gallbladder stasis and gallstones. May 11, 2015

Vitamin D might have an impact on gallstone disease. Sep 30, 2016

Wheat bran consumption prevents cholesterol gallstones. Aug 24, 1984

Both excessive ascorbic acid intake and deficiency lower biliary cholesterol saturation and bile synthesis. Mar 01, 1981

Casein (cow's milk protein) consumption may be associated with gallstone formation. Nov 01, 1979

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin reduces gallstone formation and biliary cholesterol concentration in mice. Oct 01, 1992

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice.Sep 01, 2009

Dietary garlic and onion reduce the incidence of diet-induced cholesterol gallstones in mice. Oct 01, 2003

Dietary garlic and onion regresses preestablished cholesterol gallstones in experimental mice. Feb 10, 2010

EGCG reduces the susceptibility to cholesterol gallstone formation through the regulation of inflammation.Dec 01, 2008

EPA prevents the formation of cholesterol gallstones in an animal model. Oct 01, 1997

Fish oil inhibits cholesterol crystallization and gallstone formation in an animal model. Sep 01, 1995

Garlic and onion have anti-lithogenic activity in formation of cholesterol gallstones. Jan 14, 2010

L. tridentata (chaparral) significantly reduces gallstone formation and gallbladder bile cholesterol concentration.Sep 01, 2005

Psyllium protects against cholesterol gallstone formation.Apr 01, 1999

The effect of ellagic acid on intra-abdominal adhesions caused by gallstones.Nov 09, 2021

Garlic oil is more effective than monoctanoin in dissolving gallstones. Oct 01, 2000

Lecithin may play a therapeutic role in preventing and treating gallstones. Jul 01, 1984

Low levels of vitamin C (ascorbic acid) may contribute to the formation of cholesterol gallstones. Feb 01, 1993

Magnesium consumption reduces gallstone risk - Article 2Feb 01, 2008

Melatonin may be therapeutic in gallstones and gallbladder inflammation. Oct 01, 2008

Silymarin has anticholestatic properities which may be of value in the treatment of gallstone formation. Jan 01, 2006

These spices prevent the induction of cholesterol gallstones by lithogenic high cholesterol diet and also regress the pre-established cholesterol gallstones.Jul 05, 2015

Gallstones Related Articles

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Gallstones

View the Evidence:
39 Abstracts with Gallstones Research