Gastroesophageal Reflux

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44 Substances Researched for Gastroesophageal Reflux
NameACCKFocus
Melatonin321Locked
Prickly Pear Cactus220Locked
Vitamin B-12220Locked
Astaxanthin211Locked
Lactobacillus Acidophilus211Locked
Lactobacillus plantarum211Locked
Sodium Bicarbonate211Locked
Aloe Vera110Locked
Betaine 110Locked
Fiber110Locked
Folic Acid 110Locked
Fruit: All110Locked
Lactobacillus delbrueckii Subsp110Locked
Lactobacillus probiotics110Locked
Lactobacillus reuteri110Locked
Lactobacillus rhamnosus 110Locked
Methionine110Locked
Miso 110Locked
Neem110Locked
Olive110Locked
Olive leaf extract110Locked
Pectin110Locked
Psyllium110Locked
Rose 110Locked
Soup110Locked
Tryptophan110Locked
Vegetables: All 110Locked
Vitamin B-6110Locked
Water110Locked
Ginger25Locked
Quercetin23Locked
Celery12Locked
Ellagic Acid12Locked
Noni12Locked
Red Sage12Locked
Vitamin E12Locked
Catechin 11Locked
Curcumin11Locked
Damiana11Locked
EGCG (Epigallocatechin gallate)11Locked
Lactobacillus fermentum11Locked
Oleic acid11Locked
Spinach11Locked
Tannic Acid11Locked
11 Problem Substances Researched for Gastroesophageal Reflux
NameACCKFocus
Proton-Pump Inhibitors752Locked
Histamine Receptor Antagonists332Locked
Gluten220Locked
Omeprazole (trade name Prilosec)220Locked
Wheat220Locked
Bisphosphonates110Locked
Cow Milk110Locked
Lansoprazole110Locked
Ranitidine110Locked
Statin Drugs110Locked
Acid Blockers12Locked
6 Therapeutic Actions Researched for Gastroesophageal Reflux
NameACCKFocus
Acupuncture120Locked
Dietary Modification: Wheat/Gluten Free220Locked
Placebo Effect120Locked
Therapeutic Breathing120Locked
Dietary Modification: Vegetarian110Locked
Deep Breathing11Locked
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View the Evidence:
59 Abstracts with Gastroesophageal Reflux Research

[+]

Placebo treatment produces a response in the treatment of gastrooesophageal reflux disease.Jul 01, 2010

Pubmed Data : Aliment Pharmacol Ther. 2010 Jul;32(1):29-42. Epub 2010 Mar 26. PMID: 20353496
Article Published Date : Jul 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Gastroesophageal Reflux
Therapeutic Actions : Placebo Effect
[+]

To some extent, breathing exercises can relieve the symptoms of patients with GERD.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Palliat Med. 2020 Mar ;9(2):405-413. Epub 2020 Mar 17. PMID: 32233626
Article Published Date : Feb 29, 2020
Study Type : Meta Analysis
Additional Links
Diseases : Gastroesophageal Reflux
Therapeutic Actions : Therapeutic Breathing
Pharmacological Actions : Gastrointestinal Agents
[+]

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

Pubmed Data : J Pineal Res. 2006 Oct;41(3):195-200. PMID: 16948779
Article Published Date : Oct 01, 2006
Study Type : Human Study
Additional Links
Substances : Betaine , Folic Acid , Melatonin, Methionine, Tryptophan, Vitamin B-12, Vitamin B-6
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Proton Pump Inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

A gluten free diet could be a useful approach in reducing GERD symptoms in adult celiac patients. Sep 01, 2008

Pubmed Data : J Gastroenterol Hepatol. 2008 Sep ;23(9):1368-72. PMID: 18853995
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Gastroesophageal Reflux
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free
Problem Substances : Gluten, Wheat
[+]

A standardized extract of Opuntia ficus-indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort.Mar 15, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2021 Mar 16. Epub 2021 Mar 16. PMID: 33724592
Article Published Date : Mar 15, 2021
Study Type : Human Study
Additional Links
Substances : Olive leaf extract, Prickly Pear Cactus
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Gastrointestinal Agents
[+]

Acupuncture has therapeutic value in the treatment of gastroesophageal reflux.Aug 27, 2008

Pubmed Data : J Agric Food Chem. 2008 Aug 27;56(16):7502-9. Epub 2008 Jul 26. PMID: 20697939
Article Published Date : Aug 27, 2008
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Gastroesophageal Reflux
Therapeutic Actions : Acupuncture
[+]

Acupuncture is more effective than doubling the proton pump inhibitor dose in controlling GERD symptoms in patients who fail standard dose proton pump inhibitors. Nov 15, 2007

Pubmed Data : Aliment Pharmacol Ther. 2007 Nov 15;26(10):1333-44. Epub 2007 Sep 17. PMID: 17875198
Article Published Date : Nov 15, 2007
Study Type : Human Study
Additional Links
Diseases : Gastroesophageal Reflux
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Astaxanthin reduces reflux symptoms in patients, especially in those with pronounced H. pylori infection.Jun 01, 2008

Pubmed Data : Phytomedicine. 2008 Jun;15(6-7):391-9. Epub 2008 May 7. PMID: 18467083
Article Published Date : Jun 01, 2008
Study Type : Human Study
Additional Links
Substances : Astaxanthin
Diseases : Acid Reflux, Helicobacter Pylori Infection
Pharmacological Actions : Antioxidants
[+]

Children exposed to proton pump inhibitor therapy are at higher risk for the development of Clostridium difficile-associated disease. Dec 29, 2009

Pubmed Data : Aliment Pharmacol Ther. 2009 Dec 29. Epub 2009 Dec 29. PMID: 20047577
Article Published Date : Dec 29, 2009
Study Type : Human Study
Additional Links
Diseases : Acid Reflux: In Infants & Children, Childhood Infections, Clostridium Infections, Infant Infections
Additional Keywords : Iatrogenic Disease
Problem Substances : Proton-Pump Inhibitors
[+]

Consumption of rose oil soft capsule alleviates cardinal GERD symptoms similar to omeprazole.Apr 30, 2021

Pubmed Data : Complement Ther Clin Pract. 2021 May ;43:101361. Epub 2021 Mar 11. PMID: 33735635
Article Published Date : Apr 30, 2021
Study Type : Human Study
Additional Links
Substances : Rose
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Discontinuation of proton pump inhibitors (PPIs) is associated with rebound secretion of gastric acid.Jul 01, 2010

Pubmed Data : Am J Gastroenterol. 2010 Jul;105(7):1531-7. Epub 2010 Mar 23. PMID: 20332770
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Dyspepsia
Additional Keywords : Drugs that Cause the Problem they Treat
[+]

Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease.Nov 30, 2015

Pubmed Data : J Tradit Chin Med. 2015 Dec ;35(6):632-6. PMID: 26742306
Article Published Date : Nov 30, 2015
Study Type : Human Study
Additional Links
Substances : Aloe Vera
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Gastrointestinal Agents
[+]

Efficacy of a food supplement containing Lactobacillus acidophilus LA14, peptides, and a multivitamin complex in improving gastroesophageal reflux diseaseJun 03, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Jun 4 ;16(11). Epub 2024 Jun 4. PMID: 38892690
Article Published Date : Jun 03, 2024
Study Type : Human Study
Additional Links
Substances : Lactobacillus Acidophilus
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Gastrointestinal Agents
[+]

Excessive duodenal lipid-induced release of apoA-IV and CCK in GERD.Mar 31, 2012

Pubmed Data : Neurogastroenterol Motil. 2012 Apr ;24(4):350-e168. Epub 2012 Feb 2. PMID: 22300015
Article Published Date : Mar 31, 2012
Study Type : Human Study
Additional Links
Diseases : Gastroesophageal Reflux
[+]

Fiber-enriched diet helps to control symptoms and improves esophageal motility in patients with non-erosive gastroesophageal reflux disease.Jun 06, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2018 Jun 7 ;24(21):2291-2299. PMID: 29881238
Article Published Date : Jun 06, 2018
Study Type : Human Study
Additional Links
Substances : Fiber
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Gastrointestinal Agents
[+]

Gastroesophageal reflux in infants resistant to drug treatment responds favorably to the elimination of cow's milk. Sep 01, 2011

Pubmed Data : Gut Liver. 2011 Sep ;5(3):298-301. Epub 2011 Aug 18. PMID: 21927657
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Diseases : Allergy: Cow's Milk , Gastroesophageal Reflux, Gastroesophageal Reflux: Infant and Children
Problem Substances : Cow Milk
[+]

Intake of miso soup was associated with lower epigastric symptoms.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2018 ;64(5):367-373. PMID: 30381627
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Miso , Soup
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Gastroprotective
[+]

Lactobacillus probiotics could restore the gastric barrier effect in patients treated with proton pump inhibitors. Sep 30, 2012

Pubmed Data : J Clin Gastroenterol. 2012 Oct ;46 Suppl:S18-26. PMID: 22955351
Article Published Date : Sep 30, 2012
Study Type : Human Study
Additional Links
Substances : Lactobacillus delbrueckii Subsp, Lactobacillus plantarum, Lactobacillus probiotics, Lactobacillus rhamnosus
Diseases : Dysbiosis, Gastroesophageal Reflux
Pharmacological Actions : Gastroprotective
Additional Keywords : Increased Risk, Microbiota, Risk Reduction, Significant Treatment Outcome
Problem Substances : Proton-Pump Inhibitors
[+]

Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants.Apr 01, 2011

Pubmed Data : Eur J Clin Invest. 2011 Apr;41(4):417-22. Epub 2010 Nov 26. PMID: 21114493
Article Published Date : Apr 01, 2011
Study Type : Human Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Acid Reflux: In Infants & Children, Delayed Gastric Emptying
[+]

Liquid pectin reduced gastroesophageal reflux in children with cerebral palsy. Apr 16, 2008

Pubmed Data : BMC Gastroenterol. 2008 Apr 16;8:11. PMID: 18412980
Article Published Date : Apr 16, 2008
Study Type : Human Study
Additional Links
Substances : Pectin
Diseases : Cerebral Palsy, Gastroesophageal Reflux
[+]

Low prevalence of gastroesophageal reflux symptoms in vegetarians.Apr 11, 2021

Pubmed Data : Indian J Gastroenterol. 2021 Apr 12. Epub 2021 Apr 12. PMID: 33846945
Article Published Date : Apr 11, 2021
Study Type : Human Study
Additional Links
Substances : Fruit: All, Vegetables: All
Diseases : Gastroesophageal Reflux
Therapeutic Actions : Dietary Modification: Vegetarian
Pharmacological Actions : Gastroprotective
Additional Keywords : Risk Reduction
[+]

Medically treated patients with mild or absent GERD symptoms have significantly higher odds of adenocarcinogenesis compared with medically treated patients with severe GERD symptoms.Jul 01, 2011

Pubmed Data : Arch Surg. 2011 Jul;146(7):851-8. PMID: 21768433
Article Published Date : Jul 01, 2011
Study Type : Human Study
Additional Links
Diseases : Esophageal Cancer, Gastroesophageal Reflux
Problem Substances : Proton-Pump Inhibitors
[+]

Melatonin has a role in the improvement of gastroesophageal reflux disease.Jan 01, 2010

Pubmed Data : BMC Gastroenterol. 2010;10:7. Epub 2010 Jan 18. PMID: 20082715
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Gastroesophageal Reflux
Additional Keywords : Drug: Omeprazole
[+]

Mucosave formulation is an effective treatment for reducing the frequency and intensity of symptoms associated with gastroesophageal reflux.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:2581461. Epub 2016 Aug 12. PMID: 27818697
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Olive, Prickly Pear Cactus, Sodium Bicarbonate
Diseases : Gastroesophageal Reflux
Additional Keywords : Plant Extracts
[+]

Neem bark has therapeutic potential for controlling gastric hypersecretion and gastroesophageal and gastroduodenal uclcers. Oct 29, 2004

Pubmed Data : Life Sci. 2004 Oct 29;75(24):2867-78. PMID: 15454339
Article Published Date : Oct 29, 2004
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : Gastroduodenal Ulcer, Gastroesophageal Reflux, Peptic Ulcer
Pharmacological Actions : Proton Pump Inhibitor
[+]

Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.Jul 01, 2010

Pubmed Data : Gastroenterology. 2010 Jul;139(1):93-101. Epub 2010 Mar 27. PMID: 20353792
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Gastroesophageal Reflux, Osteoporosis
Problem Substances : Histamine Receptor Antagonists
[+]

Proton pump inhibitors are not superior to placebo and increase the risk of respiratory tract infections in infants with symptoms of GERD.Apr 01, 2009

Pubmed Data : J Pediatr. 2009 Apr;154(4):514-520.e4. Epub 2008 Dec 3. PMID: 19054529
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Gastroesophageal Reflux, Gastroesophageal Reflux: Infant and Children
Additional Keywords : Drugs that are Worse than Placebo
Problem Substances : Lansoprazole
[+]

Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy, indicating the drug causes rebound acid hypersecretion (RAHS).Jul 01, 2009

Pubmed Data : Gastroenterology. 2009 Jul;137(1):80-7, 87.e1. Epub 2009 Apr 10. PMID: 19362552
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Dyspepsia
Additional Keywords : Drug: Omeprazole
Problem Substances : Omeprazole (trade name Prilosec)
[+]

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642
Article Published Date : Apr 01, 1983
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Acid Reflux, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency
Pharmacological Actions : Anti-Ulcer Agents
Problem Substances : Histamine Receptor Antagonists, Ranitidine
[+]

Relationship between long-term use of proton pump inhibitor (PPI) and hypomagnesemia in patients with gastroesophageal reflux disease.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Caspian J Intern Med. 2022 ;13(1):107-112. PMID: 35178215
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Diseases : Gastroesophageal Reflux, Magnesium Deficiency
Additional Keywords : Increased Risk
Problem Substances : Proton-Pump Inhibitors
[+]

Statin therapy was associated with higher odds of being diagnosed with esophagitis and gastroesophageal reflux disease/dyspepsia.Oct 27, 2017

Pubmed Data : Clin Drug Investig. 2017 Oct 28. Epub 2017 Oct 28. PMID: 29081029
Article Published Date : Oct 27, 2017
Study Type : Human Study
Additional Links
Diseases : Dyspepsia, Esophagitis, Gastroesophageal Reflux, Statin-Induced Pathologies
Additional Keywords : Increased Risk
Problem Substances : Statin Drugs
[+]

The GFD is associated with a rapid and persistent improvement in reflux symptoms in classicially untreated celiac disease patients that resembles the healthy population.Mar 01, 2011

Pubmed Data : Clin Gastroenterol Hepatol. 2011 Mar ;9(3):214-9. Epub 2010 Jun 30. PMID: 20601132
Article Published Date : Mar 01, 2011
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Gastroesophageal Reflux
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free
Problem Substances : Gluten, Wheat
[+]

The relapse rate after short-term treatment with omeprazole was high. Mar 06, 2017

Pubmed Data : Rev Gastroenterol Mex. 2017 Mar 7. Epub 2017 Mar 7. PMID: 28283313
Article Published Date : Mar 06, 2017
Study Type : Human Study
Additional Links
Diseases : Gastroesophageal Reflux
Additional Keywords : Increased Risk
Problem Substances : Proton-Pump Inhibitors
[+]

There is a high prevalence of celiac disease, Helicobacter pylori and gastroesophageal reflux in patients with refractory iron deficiency anemia.Feb 01, 2008

Pubmed Data : J Trop Pediatr. 2008 Feb;54(1):43-53. Epub 2007 Sep 30. PMID: 17908698
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Diseases : Anemia, Anemia: Refractory Iron Deficiency , Celiac Disease, Gastroesophageal Reflux, Helicobacter Pylori Infection
Additional Keywords : Diseases that are Linked
[+]

Treatment of functional constipation by Psyllium seed in patients with gastroesophageal reflux disease leads to improvement and lessens its recurrence.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18763294. PMID: 29607676
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Psyllium
Diseases : Constipation, Gastroesophageal Reflux
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Omeprazole (trade name Prilosec)
[+]

Treatment with proton pump inhibitors increases the rate of subsequent treatment with anti-osteoporotic drugs.Jul 01, 2010

Pubmed Data : Pharmacoepidemiol Drug Saf. 2010 Jul;19(7):763-9. PMID: 20582909
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Osteoporosis
Additional Keywords : Downward Spiral of Drug Treatment
Problem Substances : Bisphosphonates
[+]

Water compares favorably to acid-blocking drugs by increasing gastric pH in healthy subjects. Dec 01, 2008

Pubmed Data : Dig Dis Sci. 2008 Dec;53(12):3128-32. Epub 2008 May 13. PMID: 18473176
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Water
Diseases : Gastroesophageal Reflux
[+]

Acid blockers (H2 receptor blockers) have anti-ovulatory activity in rabbits. Apr 01, 2011

Pubmed Data : Eur J Contracept Reprod Health Care. 2011 Apr;16(2):142-6. Epub 2011 Jan 31. PMID: 21281096
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Gastroesophageal Reflux, Infertility: Female
Problem Substances : Acid Blockers, Histamine Receptor Antagonists
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Celery extract significantly protects the gastric mucosa and suppresses the basal gastric secretion in rats, possibly through its antioxidant potential.Jul 01, 2010

Pubmed Data : Pharm Biol. 2010 Jul ;48(7):786-93. PMID: 20645778
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Celery
Diseases : Acid Reflux, Gastric Ulcer
Pharmacological Actions : Acid Blockers, Anti-Ulcer Agents, Malondialdehyde Down-regulation
Additional Keywords : Plant Extracts
[+]

Ellagic acid inhibits the gastric proton pumps, reducing acid secretion and the occurence of stress-induced gastric lesions. Jun 01, 2008

Pubmed Data : Mol Nutr Food Res. 2008 Jun;52(6):692-700. PMID: 1663631
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Acid Reflux, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor
[+]

Ginger has a gastroprotective effect through its acid blocking and anti-Helico bacter pylori activity. Jul 01, 2009

Pubmed Data : Evid Based Complement Alternat Med. 2009 Jul 1. PMID: 19570992
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Acid Reflux, Gastroesophageal Reflux, Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, Proton Pump Inhibitor
Additional Keywords : Natural Substances Versus Drugs, Prevacid (Lansoprazole) Alternatives
[+]

Noni has therapeutic potential in ameliorating reflux esophagitis and gastric ulcer. Mar 24, 2011

Pubmed Data : J Ethnopharmacol. 2011 Mar 24 ;134(2):243-50. Epub 2010 Dec 14. PMID: 21163341
Article Published Date : Mar 24, 2011
Study Type : Animal Study
Additional Links
Substances : Noni
Diseases : Gastric Ulcer, Gastroesophageal Reflux
Pharmacological Actions : Anti-Ulcer Agents
Additional Keywords : Plant Extracts
[+]

Quercetin and vitamin E attenuate the severity of reflux oesophagitis and prevent mucosal damage. Dec 28, 2005

Pubmed Data : J Agric Food Chem. 2005 Dec 28;53(26):10306-9. PMID: 18547560
Article Published Date : Dec 28, 2005
Study Type : Animal Study
Additional Links
Substances : Quercetin, Vitamin E
Diseases : Esophageal Reflux, Esophagitis, Gastroesophageal Reflux
[+]

Red sage (Salvia miltiorrhiza) contains a compound which inhibits the gastric proton pump, reducing acid production and lesions. Aug 01, 1990

Pubmed Data : Planta Med. 1990 Aug;56(4):360-3. PMID: 2173008
Article Published Date : Aug 01, 1990
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : Acid Reflux, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor
[+]

A review of the medical literature shows that proton pump inhibitor use is associated with a variety of metabolic, infectious, cardiac, and orthopedic adverse outcomes.Feb 06, 2010

Pubmed Data : J Voice. 2010 Feb 6. Epub 2010 Feb 6. PMID: 20144536
Article Published Date : Feb 06, 2010
Study Type : Review
Additional Links
Diseases : Acid Reflux
Problem Substances : Proton-Pump Inhibitors
[+]

Breathing exercises in gastroesophageal reflux disease.Jul 15, 2022

Pubmed Data : Dysphagia. 2022 Jul 16. Epub 2022 Jul 16. PMID: 35842548
Article Published Date : Jul 15, 2022
Study Type : Review
Additional Links
Diseases : Gastroesophageal Reflux
Therapeutic Actions : Deep Breathing
Pharmacological Actions : Gastrointestinal Agents
[+]

Catechins such as EGCG (found in green tea) act as proton pump inhibitors. Nov 01, 1992

Pubmed Data : J Pharm Pharmacol. 1992 Nov;44(11):926-8. PMID: 1361539
Article Published Date : Nov 01, 1992
Study Type : In Vitro Study
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate)
Diseases : Acid Reflux
Pharmacological Actions : Proton Pump Inhibitor
[+]

Clinical trials reveal that proton pump inhibitor therapy is not an effective treatment for common infant GERD-associated symptoms.Mar 01, 2010

Pubmed Data : Ann Pharmacother. 2010 Mar;44(3):572-6. Epub 2010 Feb 2. PMID: 20124466
Article Published Date : Mar 01, 2010
Study Type : Review
Additional Links
Diseases : Gastroesophageal Reflux
Problem Substances : Proton-Pump Inhibitors
[+]

Curcumin inhibits esophageal activation in response to acid. Feb 01, 2009

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G388-98. Epub 2008 Dec 12. PMID: 19074641
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Damiana (Turnera ulmifolia) has significant anti-acid and antiulcerogenic effects.Apr 01, 2002

Pubmed Data : Biol Pharm Bull. 2002 Apr;25(4):487-91. PMID: 11995930
Article Published Date : Apr 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Damiana
Diseases : Duodenal Ulcer, Gastric Ulcer, Gastroesophageal Reflux
[+]

Ginger is superior to lansoprazole at blocking ulcer formation.Mar 01, 2007

Pubmed Data : Mol Nutr Food Res. 2007 Mar;51(3):324-32. PMID: 17295419
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Gastric Ulcer, Gastroesophageal Reflux
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Lactobacillus sp. Facilitate the Repair of DNA Damage Caused by Bile-Induced Reactive Oxygen SpeciesJun 20, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2023 Jun 21 ;12(7). Epub 2023 Jun 21. PMID: 37507854
Article Published Date : Jun 20, 2023
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus Acidophilus, Lactobacillus fermentum, Lactobacillus plantarum
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Anti-Inflammatory Agents, DNA Repair Up-regulation, Gastroprotective, Genoprotective
[+]

Magnesium deficiency is an under-reported and potentially serious side effect of proton pump inhibitors.Jan 01, 2009

Pubmed Data : Ned Tijdschr Geneeskd. 2009;153:A711. PMID: 19930736
Article Published Date : Jan 01, 2009
Study Type : Commentary
Additional Links
Diseases : Acid Reflux, Gastric Ulcer, Magnesium Deficiency
Additional Keywords : Drug: Omeprazole
[+]

Melatonin may provide a safe and effective alternative to proton-pump inhibitors in the treatment of gastroesophageal reflux disease.Jul 01, 2008

Pubmed Data : Altern Ther Health Med. 2008 Jul-Aug;14(4):54-8. PMID: 18616070
Article Published Date : Jul 01, 2008
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Gastroesophageal Reflux
Pharmacological Actions : Proton Pump Inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Oleic acid may be a potent inhibitor of the proton pumps. Mar 01, 1991

Pubmed Data : Res Commun Chem Pathol Pharmacol. 1991 Mar;71(3):337-50. PMID: 1646470
Article Published Date : Mar 01, 1991
Study Type : In Vitro Study
Additional Links
Substances : Oleic acid
Diseases : Acid Reflux, Gastric Ulcer
Pharmacological Actions : Proton Pump Inhibitor
[+]

Quercetin inhibits gastric proton pumps. Jan 01, 1992

Pubmed Data : J Enzyme Inhib. 1992;5(4):293-8. PMID: 1285250
Article Published Date : Jan 01, 1992
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Acid Reflux
Pharmacological Actions : Proton Pump Inhibitor
[+]

Review: Astaxanthin shows demonstrable promise for slowing a broad range of age-related functional declines.Dec 01, 2011

Pubmed Data : Altern Med Rev. 2011 Dec ;16(4):355-64. PMID: 22214255
Article Published Date : Dec 01, 2011
Study Type : Review
Additional Links
Substances : Astaxanthin
Diseases : Acid Reflux, Aging, Cognitive Decline/Dysfunction, DNA damage, Oxidative Stress, Smoking
[+]

Spinach displays significant antacid activity be it in the raw juice form or as an extract in methanol.Jul 11, 2016

Pubmed Data : J Complement Integr Med. 2016 Jul 12. Epub 2016 Jul 12. PMID: 27404904
Article Published Date : Jul 11, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sodium Bicarbonate, Spinach
Diseases : Acid Reflux
Pharmacological Actions : Antacids
Additional Keywords : Plant Extracts
[+]

Tannic acid inhibits the gastric proton pump, indicating its anti-secretory and anti-ulcerogenic properties. Apr 01, 1992

Pubmed Data : J Nat Prod. 1992 Apr;55(4):513-6. PMID: 1324983
Article Published Date : Apr 01, 1992
Study Type : In Vitro Study
Additional Links
Substances : Tannic Acid
Diseases : Acid Reflux, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor

Copyright: rob3000 / 123RF Stock Photo

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Gastroesophageal reflux disease, also known as acid reflux disease, often responds well to dietary modification, specifically a wheat/gluten and cow's milk free diet (see articles below).  On the other hand, there are some evidence-based palliative approaches that do not rely on the chemical class of drugs known as acid blockers, and which include proton pump inhibitors and histamine receptor antagonists, both of which have a wide range of underreported adverse health effects.  Below you will find described several dozen natural substances, including water, that have clinically proven therapeutic effects in addressing the condition.

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