Gastroesophageal Reflux

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44 Substances Researched for Gastroesophageal Reflux
11 Problem Substances Researched for Gastroesophageal Reflux
6 Therapeutic Actions Researched for Gastroesophageal Reflux
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View the Evidence:
59 Abstracts with Gastroesophageal Reflux Research

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Pubmed Data : Aliment Pharmacol Ther. 2010 Jul;32(1):29-42. Epub 2010 Mar 26. PMID: 20353496
Study Type : Meta Analysis
Additional Links
Therapeutic Actions : Placebo Effect
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Palliat Med. 2020 Mar ;9(2):405-413. Epub 2020 Mar 17. PMID: 32233626
Study Type : Meta Analysis
Additional Links
Therapeutic Actions : Therapeutic Breathing
Pharmacological Actions : Gastrointestinal Agents
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Pubmed Data : J Pineal Res. 2006 Oct;41(3):195-200. PMID: 16948779
Study Type : Human Study
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Pubmed Data : J Gastroenterol Hepatol. 2008 Sep ;23(9):1368-72. PMID: 18853995
Study Type : Human Study
Additional Links
Problem Substances : Gluten, Wheat
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2021 Mar 16. Epub 2021 Mar 16. PMID: 33724592
Study Type : Human Study
Additional Links
Pharmacological Actions : Gastrointestinal Agents
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Pubmed Data : J Agric Food Chem. 2008 Aug 27;56(16):7502-9. Epub 2008 Jul 26. PMID: 20697939
Study Type : Human Study
Additional Links
Therapeutic Actions : Acupuncture
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Pubmed Data : Aliment Pharmacol Ther. 2007 Nov 15;26(10):1333-44. Epub 2007 Sep 17. PMID: 17875198
Study Type : Human Study
Additional Links
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Pubmed Data : Phytomedicine. 2008 Jun;15(6-7):391-9. Epub 2008 May 7. PMID: 18467083
Study Type : Human Study
Additional Links
Substances : Astaxanthin
Pharmacological Actions : Antioxidants
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Pubmed Data : Aliment Pharmacol Ther. 2009 Dec 29. Epub 2009 Dec 29. PMID: 20047577
Study Type : Human Study
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Pubmed Data : Complement Ther Clin Pract. 2021 May ;43:101361. Epub 2021 Mar 11. PMID: 33735635
Study Type : Human Study
Additional Links
Substances : Rose
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Natural Substances Versus Drugs
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Pubmed Data : Am J Gastroenterol. 2010 Jul;105(7):1531-7. Epub 2010 Mar 23. PMID: 20332770
Study Type : Human Study
Additional Links
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Pubmed Data : J Tradit Chin Med. 2015 Dec ;35(6):632-6. PMID: 26742306
Study Type : Human Study
Additional Links
Substances : Aloe Vera
Pharmacological Actions : Gastrointestinal Agents
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Jun 4 ;16(11). Epub 2024 Jun 4. PMID: 38892690
Study Type : Human Study
Additional Links
Pharmacological Actions : Gastrointestinal Agents
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Pubmed Data : Neurogastroenterol Motil. 2012 Apr ;24(4):350-e168. Epub 2012 Feb 2. PMID: 22300015
Study Type : Human Study
Additional Links
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2018 Jun 7 ;24(21):2291-2299. PMID: 29881238
Study Type : Human Study
Additional Links
Substances : Fiber
Pharmacological Actions : Gastrointestinal Agents
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Pubmed Data : Gut Liver. 2011 Sep ;5(3):298-301. Epub 2011 Aug 18. PMID: 21927657
Study Type : Human Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2018 ;64(5):367-373. PMID: 30381627
Study Type : Human Study
Additional Links
Substances : Miso , Soup
Pharmacological Actions : Gastroprotective
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Pubmed Data : J Clin Gastroenterol. 2012 Oct ;46 Suppl:S18-26. PMID: 22955351
Study Type : Human Study
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Pubmed Data : Eur J Clin Invest. 2011 Apr;41(4):417-22. Epub 2010 Nov 26. PMID: 21114493
Study Type : Human Study
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Pubmed Data : BMC Gastroenterol. 2008 Apr 16;8:11. PMID: 18412980
Study Type : Human Study
Additional Links
Substances : Pectin
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Pubmed Data : Indian J Gastroenterol. 2021 Apr 12. Epub 2021 Apr 12. PMID: 33846945
Study Type : Human Study
Additional Links
Therapeutic Actions : Dietary Modification: Vegetarian
Pharmacological Actions : Gastroprotective
Additional Keywords : Risk Reduction
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Pubmed Data : Arch Surg. 2011 Jul;146(7):851-8. PMID: 21768433
Study Type : Human Study
Additional Links
Problem Substances : Proton-Pump Inhibitors
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Pubmed Data : BMC Gastroenterol. 2010;10:7. Epub 2010 Jan 18. PMID: 20082715
Study Type : Human Study
Additional Links
Substances : Melatonin
Additional Keywords : Drug: Omeprazole
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:2581461. Epub 2016 Aug 12. PMID: 27818697
Study Type : Human Study
Additional Links
Additional Keywords : Plant Extracts
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Pubmed Data : Life Sci. 2004 Oct 29;75(24):2867-78. PMID: 15454339
Study Type : Human Study
Additional Links
Substances : Neem
Pharmacological Actions : Proton Pump Inhibitor
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Pubmed Data : Gastroenterology. 2010 Jul;139(1):93-101. Epub 2010 Mar 27. PMID: 20353792
Study Type : Human Study
Additional Links
Problem Substances : Histamine Receptor Antagonists
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Pubmed Data : J Pediatr. 2009 Apr;154(4):514-520.e4. Epub 2008 Dec 3. PMID: 19054529
Study Type : Human Study
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Pubmed Data : Gastroenterology. 2009 Jul;137(1):80-7, 87.e1. Epub 2009 Apr 10. PMID: 19362552
Study Type : Human Study
Additional Links
Additional Keywords : Drug: Omeprazole
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Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642
Study Type : Human Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Caspian J Intern Med. 2022 ;13(1):107-112. PMID: 35178215
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Proton-Pump Inhibitors
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Pubmed Data : Clin Drug Investig. 2017 Oct 28. Epub 2017 Oct 28. PMID: 29081029
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Statin Drugs
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Pubmed Data : Clin Gastroenterol Hepatol. 2011 Mar ;9(3):214-9. Epub 2010 Jun 30. PMID: 20601132
Study Type : Human Study
Additional Links
Problem Substances : Gluten, Wheat
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Pubmed Data : Rev Gastroenterol Mex. 2017 Mar 7. Epub 2017 Mar 7. PMID: 28283313
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Proton-Pump Inhibitors
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Pubmed Data : J Trop Pediatr. 2008 Feb;54(1):43-53. Epub 2007 Sep 30. PMID: 17908698
Study Type : Human Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18763294. PMID: 29607676
Study Type : Human Study
Additional Links
Substances : Psyllium
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Pubmed Data : Pharmacoepidemiol Drug Saf. 2010 Jul;19(7):763-9. PMID: 20582909
Study Type : Human Study
Additional Links
Additional Keywords : Downward Spiral of Drug Treatment
Problem Substances : Bisphosphonates
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Pubmed Data : Dig Dis Sci. 2008 Dec;53(12):3128-32. Epub 2008 May 13. PMID: 18473176
Study Type : Human Study
Additional Links
Substances : Water
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Pubmed Data : Eur J Contracept Reprod Health Care. 2011 Apr;16(2):142-6. Epub 2011 Jan 31. PMID: 21281096
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Endocrine Disruptor
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Pubmed Data : Pharm Biol. 2010 Jul ;48(7):786-93. PMID: 20645778
Study Type : Animal Study
Additional Links
Substances : Celery
Additional Keywords : Plant Extracts
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Pubmed Data : Mol Nutr Food Res. 2008 Jun;52(6):692-700. PMID: 1663631
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor
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Pubmed Data : Evid Based Complement Alternat Med. 2009 Jul 1. PMID: 19570992
Study Type : Animal Study
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Pubmed Data : J Ethnopharmacol. 2011 Mar 24 ;134(2):243-50. Epub 2010 Dec 14. PMID: 21163341
Study Type : Animal Study
Additional Links
Substances : Noni
Pharmacological Actions : Anti-Ulcer Agents
Additional Keywords : Plant Extracts
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Pubmed Data : J Agric Food Chem. 2005 Dec 28;53(26):10306-9. PMID: 18547560
Study Type : Animal Study
Additional Links
Substances : Quercetin, Vitamin E
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Pubmed Data : Planta Med. 1990 Aug;56(4):360-3. PMID: 2173008
Study Type : Animal Study
Additional Links
Substances : Red Sage
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor
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Pubmed Data : J Voice. 2010 Feb 6. Epub 2010 Feb 6. PMID: 20144536
Study Type : Review
Additional Links
Diseases : Acid Reflux
Problem Substances : Proton-Pump Inhibitors
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Pubmed Data : Dysphagia. 2022 Jul 16. Epub 2022 Jul 16. PMID: 35842548
Study Type : Review
Additional Links
Therapeutic Actions : Deep Breathing
Pharmacological Actions : Gastrointestinal Agents
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Pubmed Data : J Pharm Pharmacol. 1992 Nov;44(11):926-8. PMID: 1361539
Study Type : In Vitro Study
Additional Links
Diseases : Acid Reflux
Pharmacological Actions : Proton Pump Inhibitor
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Pubmed Data : Ann Pharmacother. 2010 Mar;44(3):572-6. Epub 2010 Feb 2. PMID: 20124466
Study Type : Review
Additional Links
Problem Substances : Proton-Pump Inhibitors
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Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G388-98. Epub 2008 Dec 12. PMID: 19074641
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
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Pubmed Data : Biol Pharm Bull. 2002 Apr;25(4):487-91. PMID: 11995930
Study Type : In Vitro Study
Additional Links
Substances : Damiana
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Pubmed Data : Mol Nutr Food Res. 2007 Mar;51(3):324-32. PMID: 17295419
Study Type : In Vitro Study
Additional Links
Substances : Ginger
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2023 Jun 21 ;12(7). Epub 2023 Jun 21. PMID: 37507854
Study Type : In Vitro Study
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Pubmed Data : Ned Tijdschr Geneeskd. 2009;153:A711. PMID: 19930736
Study Type : Commentary
Additional Links
Additional Keywords : Drug: Omeprazole
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Pubmed Data : Altern Ther Health Med. 2008 Jul-Aug;14(4):54-8. PMID: 18616070
Study Type : Review
Additional Links
Substances : Melatonin
Pharmacological Actions : Proton Pump Inhibitor
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Pubmed Data : Res Commun Chem Pathol Pharmacol. 1991 Mar;71(3):337-50. PMID: 1646470
Study Type : In Vitro Study
Additional Links
Substances : Oleic acid
Pharmacological Actions : Proton Pump Inhibitor
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Pubmed Data : J Enzyme Inhib. 1992;5(4):293-8. PMID: 1285250
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Acid Reflux
Pharmacological Actions : Proton Pump Inhibitor
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Pubmed Data : Altern Med Rev. 2011 Dec ;16(4):355-64. PMID: 22214255
Study Type : Review
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Pubmed Data : J Complement Integr Med. 2016 Jul 12. Epub 2016 Jul 12. PMID: 27404904
Study Type : In Vitro Study
Additional Links
Diseases : Acid Reflux
Pharmacological Actions : Antacids
Additional Keywords : Plant Extracts
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Pubmed Data : J Nat Prod. 1992 Apr;55(4):513-6. PMID: 1324983
Study Type : In Vitro Study
Additional Links
Substances : Tannic Acid
Pharmacological Actions : Anti-Ulcer Agents, Proton Pump Inhibitor

Gastroesophageal Reflux Related Articles

Written by Dr. Jack Wolfson
Did you know that pharmaceuticals used to treat heartburn actually increase gastrointestinal problems? Fortunately, there are natural ways to fight off acid reflux.
Imagine a world where acid reflux can be managed naturally, without the need for long-term medication. Recent research and centuries-old wisdom suggest that probiotics like Lactobacillus acidophilus could be the key to long-lasting relief. Combining DIY fermented foods with cutting-edge science, this article explores the powerful role of acidophilus in supporting digestive health and preventing GERD.
Contrary to popular belief, low stomach acid is often the underlying cause of heartburn and GERD, not excess acid
Written by Sayer Ji, Founder
Could the water people swallow their acid reflux pills with be more therapeutic than the drugs themselves? In 2008, a remarkable study took place comparing a glass of water to an antacid and "acid blocking" drugs, in their overall effect in increasing gastric pH (i.e. making it more alkaline) in healthy subjects.
Written by Dr. Rivkah Roth
Diabetes, mineral and nutritional deficiencies. Why taking supplements may not be the straight forward solution they are made out to be
Written by Dr. Michael Murray
Put down the antacids! New study shows that acid blockers are detrimental to cardiovascular health
Written by GMI Reporter
For years, proton pump inhibitors were marketed to the public for stomach relief from 'excess acid production,' without the slightest clue that they were contributing to the burgeoning epidemic of neurodegenerative disease. All that has now changed...
If you're struggling with heartburn, constipation or other uncomfortable symptoms of gastroesophageal reflux disease (GERD), adding fiber to your diet, in the form of psyllium seed, may help
Written by Sayer Ji, Founder
What happens when we take a multi-billion dollar pharmaceutical and pitch it against a farm-aceutical one, ginger? Acid-blockers are taken by millions around the world, daily, but they carry severe unintended, adverse health effects, not the least of which are gastric cancer. Ginger, on the other hand, has over 100 potential side benefits. So, which is more logical to use as a medicine?
In the battle against heartburn and indigestion, could the humble ginger root provide a natural, safe, and effective solution that rivals the efficacy of conventional acid-blocking drugs?

Gastroesophageal reflux disease, also known as acid reflux disease, often responds well to dietary modification, specifically a wheat/gluten and cow's milk free diet (see articles below).  On the other hand, there are some evidence-based palliative approaches that do not rely on the chemical class of drugs known as acid blockers, and which include proton pump inhibitors and histamine receptor antagonists, both of which have a wide range of underreported adverse health effects.  Below you will find described several dozen natural substances, including water, that have clinically proven therapeutic effects in addressing the condition.

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