Head and Neck Cancer

Name	AC	CK
Honey	5	44
Curcumin	20	29
Aloe Vera	2	20
Cannabis	2	20
Fiber	2	20
Turmeric	2	20
Neem	3	14
Coffee	2	11
Green Tea	2	11
Licorice	2	11
Anthocyanins	1	10
Antioxidants: Fat Soluble	1	10
Arginine	1	10
Chamomile	1	10
Flavonoids	1	10
Folate	1	10
Glutamine	1	10
Pomegranate	1	10
Silver (nanoparticles)	1	10
St. Johns Wort	1	10
Thyme	1	10
Tocopherols	1	10
Vitamin C	1	10
Zataria multiflora	1	10
EGCG (Epigallocatechin gallate)	6	9
Resveratrol	5	8
Honokiol	5	7
Crocin	1	5
Lactoferrin	3	4
Sulforaphane	4	4
Deguelin	2	3
Piperlongumine	2	3
Berbamine	1	2
Betulinic acid	2	2
Cannabidiol	1	2
Fisetin	2	2
Formononetin	1	2
Lupeol	1	2
Lycopene	1	2
Quercetin	2	2
Silibinin	1	2
Viruses: Beneficial	1	2
Vitamin D	2	2
Wogonin	1	2
6-Shogaol	1	1
Berberine	1	1
Biochanin A	1	1
Bitter Melon	1	1
Broccoli Sprouts	1	1
Cafestol	1	1
Caffeic Acid	1	1
Caffeic acid phenethyl ester	1	1
Cinnamon	1	1
Curcumol	1	1
Emodin	1	1
Fucoidan	1	1
Genistein	1	1
Gold (nanoparticles)	1	1
Grape Seed Extract	1	1
Holy Basil	1	1
MSM (Methylsulfonylmethane)	1	1
Melatonin	1	1
NAC (N-acetyl-L-cysteine)	1	1
Proanthocyanidins	1	1
Propolis: Brazillian	1	1
Rosmarinic acid	1	1
S-Adenosylmethionine (SAMe)	1	1
Sandalwood	1	1
Sweet Potato	1	1
Thymoquinone	1	1
Vitamin A	1	1

Name	AC	CK
Meat	1	10
Morphine	1	2
Organophosphate Pesticides	1	1

Name	AC	CK
Hyperbaric Treatment	2	30
Laser Treatment: Low-Level	3	21
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Dietary Modification: Mediterranean Diet	1	10
Light Therapy: Colored	1	1
Photodynamic therapy	1	1

Name	AC	CK	Focus
Radiotherapy	3	13
Mobile Phone Radiation	1	5

Higher dietary fiber intake, prior to the initiation of treatment, may prolong survival time, in those with a new head and neck cancer diagnosis.Sep 26, 2019

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Pubmed Data : Eur J Cancer Prev. 2016 Aug 1. Epub 2016 Aug 1. PMID: 27483412

Article Published Date : Jul 31, 2016

Study Type : Human Study

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Diseases : Head and Neck Cancer

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

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Pubmed Data : Am J Cancer Res. 2016 ;6(2):157-72. Epub 2016 Jan 15. PMID: 27186393

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Breast Cancer, Head and Neck Cancer, Lung Cancer

Problem Substances : Morphine

Adverse Pharmacological Actions : Immunosuppressive

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Nisin ZP, a bacteriocin and food preservative, inhibits head and neck cancer tumorigenesis and prolongs survival.Dec 31, 2014

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This study proposes a novel molecular rationale for antitumor activities of green tea in head and neck cancers.Nov 14, 2016

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Pubmed Data : Phytomedicine. 2016 Nov 15 ;23(12):1344-1355. Epub 2016 Aug 19. PMID: 27765354

Article Published Date : Nov 14, 2016

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Head and Neck Cancer

Pharmacological Actions : Apoptotic, MicroRNA modulator

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Treatment of HNSCC cells with combinations of CUR and RES can be more effective in inhibiting in vivo and in vitro cancer cell growth than the treatment with CUR alone.Nov 14, 2014

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Pubmed Data : Nutr Cancer. 2020 Apr 14:1-15. Epub 2020 Apr 14. PMID: 32285707

Article Published Date : Apr 13, 2020

Study Type : Review

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Substances : Curcumol

Diseases : Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Anticancer potential of selected flavonols: fisetin, kaempferol, and quercetin on head and neck cancers.Mar 04, 2021

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Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:6793456. Epub 2017 Jan 12. PMID: 28167973

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Caffeic acid phenethyl ester

Diseases : Head and Neck Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

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Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells.Aug 08, 2021

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Pubmed Data : J Egypt Natl Canc Inst. 2021 Aug 9 ;33(1):20. Epub 2021 Aug 9. PMID: 34368899

Article Published Date : Aug 08, 2021

Study Type : In Vitro Study

Additional Links

Substances : acetyl-11-keto-beta-boswellic acid, Frankincense

Diseases : Head and Neck Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Plant Extracts

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Combination of photodynamic therapy and Sulforaphane led to enhanced cytotoxic effect on head and neck cancer cells.Dec 31, 2014

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Pubmed Data : Gen Physiol Biophys. 2015 Jan ;34(1):13-21. Epub 2014 Nov 14. PMID: 25395599

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Pubmed Data : Arch Otolaryngol Head Neck Surg. 2009 Feb;135(2):190-7. PMID: 19221248

Article Published Date : Feb 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Antineoplastic Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Deguelin induces apoptosis by targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell cancer cell lines.Dec 31, 2014

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Pubmed Data : Apoptosis. 2020 Sep 7. Epub 2020 Sep 7. PMID: 32894380

Article Published Date : Sep 06, 2020

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Essential oil of Cinnamon exhibits significant anticancer activity against head and neck squamous cell carcinoma cells in vitro.Oct 31, 2015

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Pubmed Data : J BUON. 2015 Nov-Dec;20(6):1518-25. PMID: 26854449

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Pubmed Data : Mol Med Rep. 2019 Dec ;20(6):5335-5344. Epub 2019 Oct 23. PMID: 31661135

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Pubmed Data : Molecules. 2016 Nov 24 ;21(12). Epub 2016 Nov 24. PMID: 27886147

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Polyphenols have been shown to be effective against multiple targets in cancer development and progression.Dec 31, 2015

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Pubmed Data : Nutrients. 2016;8(9). Epub 2016 Sep 9. PMID: 27618095

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Pubmed Data : Anticancer Res. 2020 Feb ;40(2):751-758. PMID: 32014917

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Pubmed Data : Invest New Drugs. 2021 Oct 6. Epub 2021 Oct 6. PMID: 34613571

Article Published Date : Oct 05, 2021

Study Type : In Vitro Study

Additional Links

Diseases : Head and Neck Cancer, Skin Cancer: Squamous Cell

Pharmacological Actions : Apoptotic, Radiosensitizer

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α- and β-Santalols directly interact with tubulin and cause mitotic arrest and cytotoxicity in oral cancer cells.Jun 25, 2015

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Pubmed Data : J Nat Prod. 2015 Jun 26 ;78(6):1357-62. Epub 2015 May 20. PMID: 25993496

Article Published Date : Jun 25, 2015

Study Type : In Vitro Study

Additional Links

Substances : Sandalwood

Diseases : Head and Neck Cancer, Oral Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Essential Oils

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Head and Neck Cancer is a Sub of the following Topic

View the Evidence: 131 Abstracts with Head and Neck Cancer Research

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Curcumin is a safe, natural bioactive substance that can effectively prevent and treat oral mucositis.Dec 31, 2020

Hyperbaric oxygenation for tumour sensitisation to radiotherapy.Jan 10, 2018

Oral administration of honey after radiotherapy could prevent moderate to severe mucositis and associated weight loss.Mar 15, 2015

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer.Dec 31, 2018

Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis.Dec 31, 2014

An extract of Glycyrrhiza can be effective for decreasing the severity of oral mucositis in head and neck cancer patients undergoing radiotherapy.Aug 31, 2017

Assessment of oxidative stress in tumors and histologically normal mucosa from patients with head and neck squamous cell carcinoma: a preliminary study.Mar 11, 2013

Chamomile gel versus urea cream to prevent acute radiation dermatitis in head and neck cancer patients.Dec 31, 2019

Coffee drinking is associated with a lower risk of colorectal, liver, female breast and head and neck cancer.Jul 26, 2017

Epigallocatechin-3-gallate mouthwash protects mucosa from radiation-induced mucositis in head and neck cancer patients.Dec 31, 2019

Glutamine significantly decreased mucositis severity in the oral cavity, pharynx and larynx induced by chemoradiotherapy.Oct 22, 2014

Green tea polyphenon E and erlotinib combination was well tolerated in patients with APLs of the head and neck.Jan 14, 2020

Higher dietary fiber intake, prior to the initiation of treatment, may prolong survival time, in those with a new head and neck cancer diagnosis.Sep 26, 2019

Low-level laser therapy seems to be effective to mitigate salivary hypofunction and increase salivary pH of patients submitted to radiotherapy.Mar 02, 2017

Moderate marijuana use is associated with reduced risk of head and neck squamous cell carcinoma.Aug 01, 2009

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival.Nov 01, 2010

Photobiomodulation reduces the impact of radiotherapy on oral health.Oct 27, 2020

Processed meat intake was positively associated with head-neck cancer.May 31, 2017

Prophylactic use of an aloe vera-based cream-based cream is thus effective in delaying radiation dermatitis in head and neck cancer.Jun 23, 2017

Protective effect of Punica granatum extract in head and neck cancer patients undergoing radiotherapy.Sep 30, 2019

Tea consumption may protect against the development of second esophageal neoplasms among head and neck squamous-cell carcinoma patients.Mar 18, 2019

The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients.Mar 31, 2017

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study.Oct 30, 2013

The ketogenic diet let to a decline in the lactate concentration in tumor tissue.Dec 31, 2012

The Mediterranean diet acts protectively against head and neck cancer overall and by cancer subsite.Jul 31, 2016

The study provided evidence on the positive effect of thyme honey on the management of radiation-induced oral mucositis.May 31, 2018

These findings provide evidence of the protective role of dietary folate intake on head and neck cancer risk.Nov 20, 2017

These findings support evidence of a protective role of dietary fiber on head and neck cancer risk.Jan 28, 2019

These results indicate that flavonoid intake is associated with lower head and neck cancer risk.Jul 18, 2017

This population-based study did not find a statistically significant increase in the risk of head and neck cancer in young adults from cannabis use.Feb 29, 2008

This study indicates the feasibility of combining hyperbaric oxygen with chemoradiation.Feb 28, 2017

This study showed an inverse association between intake of vitamin C and the incidence of HNC and HNC-subtypes.Jul 07, 2015

Turmeric extract reduces the incidence and severity of radiation-induced mucositis.Feb 06, 2020

Zataria mouthwash effectively decreases the severity of oral mucositis and mouth pain in patients with head and neck cancer treated with radiotherapy.Jun 30, 2018

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

This investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion.May 12, 2018

Holistic care approach for the effective management of severe radiation dermatitis using neem and honey.Sep 30, 2020

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.Jan 25, 2020

Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus.Feb 29, 2012

Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma. Oct 01, 2010

Curcumin is a potential radio-enhancer in head and neck cancer.Oct 01, 2009

Curcumin suppresses growth of head and neck squamous cell carcinoma.Oct 01, 2005

Curcumin suppresses the growth of head and neck squamous cell cancer. Oct 01, 2008

Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors.Feb 15, 2018

Deguelin may represent a novel and effective chemo-agent against head and neck squamous cell carcinoma.Dec 31, 2012

Honokiol may induce apoptosis and inhibit the survival/proliferation signaling pathways in oral CSC-like cells.Dec 31, 2015

In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma.Dec 31, 2017

Intra-tumoral injection of TriCurin significantly inhibited tumor growth by 85.5%.Jul 15, 2016

Lactoferrin inhibits growth of malignant tumors of the head and neck.Aug 31, 2003

Lupeol may orchestrate a bifurcated regulation of neoplastic growth and apoptosis in head and neck cancers.Mar 31, 2017

Lycopene and curcumin given 24 hours before irradiation reduced the structural damage to the salivary glands.Jan 27, 2016

Morphine can inhibit dendritic cell-mediated anti-tumor immunity by suppressing DC maturation and function.Dec 31, 2015

Nisin ZP, a bacteriocin and food preservative, inhibits head and neck cancer tumorigenesis and prolongs survival.Dec 31, 2014

Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt.Aug 14, 2020

Silibinin inhibited tumor aggressiveness in head and neck squamous cell carcinomas.Jun 07, 2015

Targeting survivin using honokiol in combination with radiation therapy may provide novel therapeutic opportunities.Feb 14, 2018

The oral administration of formononetin decelerated tumor growth through.Jan 31, 2020

This study demonstrates potent in vitro and in vivo anticancer activity of curcumin in a SIRT1-dependent fashion.Dec 31, 2014

This study proposes a novel molecular rationale for antitumor activities of green tea in head and neck cancers.Nov 14, 2016

Treatment of HNSCC cells with combinations of CUR and RES can be more effective in inhibiting in vivo and in vitro cancer cell growth than the treatment with CUR alone.Nov 14, 2014

Wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Aug 19, 2016

Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction Dec 31, 2012

Resveratrol and oxyresveratrol inhibit the expression of cancer stem cell markers and might target cancer stem cells in a hypoxia-associated tumor.Feb 28, 2022

6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines.Nov 22, 2017

A review of the biological and therapeutic activities, and anticancer properties of curcumin.Oct 31, 2015

Administration. momordicine treatment reduced HNC xenograft tumor growth.Mar 20, 2021

An overview of the therapeutic effects of curcumol in several diseases.Apr 13, 2020

Anticancer potential of selected flavonols: fisetin, kaempferol, and quercetin on head and neck cancers.Mar 04, 2021

Berberine may have potential applications as a chemotherapeutic agent for the management of head and neck squamous carcinoma.Sep 24, 2015

Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines.Feb 28, 2010

Betulinic acid has apoptotic activity against head and neck squamous cell carcinoma.Aug 31, 2003

Head and Neck Cancer

View the Evidence:
131 Abstracts with Head and Neck Cancer Research