Head and Neck Cancer

Name	AC	CK
Curcumin	22	50
Honey	6	45
Aloe Vera	3	30
EGCG (Epigallocatechin gallate)	9	30
Vitamin C	4	22
Green Tea	3	21
Cannabis	2	20
Fiber	2	20
Turmeric	2	20
Neem	3	14
Coffee	2	11
Flavonoids	2	11
Licorice	2	11
Amla Fruit	1	10
Anthocyanins	1	10
Antioxidants: Fat Soluble	1	10
Arginine	1	10
Chamomile	1	10
Egg	1	10
Folate	1	10
Glutamine	1	10
Iodine	1	10
Pomegranate	1	10
Silver (nanoparticles)	1	10
St. Johns Wort	1	10
Thyme	1	10
Tocopherols	1	10
Zataria multiflora	1	10
Resveratrol	6	9
Honokiol	5	7
Crocin	1	5
Fisetin	4	4
Lactoferrin	3	4
Sulforaphane	4	4
6-Shogaol	2	3
Deguelin	2	3
Melatonin	2	3
Piperlongumine	2	3
Amygdalin	1	2
Berbamine	1	2
Betulinic acid	2	2
Black Raspberry	1	2
Cannabidiol	1	2
Formononetin	1	2
Lupeol	1	2
Lycopene	1	2
Nisin	1	2
Organosulfur Compounds	1	2
Quercetin	2	2
Silibinin	1	2
Viruses: Beneficial	1	2
Vitamin D	2	2
Wogonin	1	2
Acai	1	1
Artemisinin	1	1
Banana	1	1
Basil	1	1
Berberine	1	1
Biochanin A	1	1
Bitter Melon	1	1
Broccoli Sprouts	1	1
Cafestol	1	1
Caffeic Acid	1	1
Caffeic acid phenethyl ester	1	1
Carotenoids	1	1
Carrot	1	1
Cinnamon	1	1
Curcuminoids	1	1
Curcumol	1	1
Demethoxycurcumin	1	1
Elecampane	1	1
Emodin	1	1
Frankincense	1	1
Fucoidan	1	1
Genistein	1	1
Goji	1	1
Gold (nanoparticles)	1	1
Grape Seed Extract	1	1
Holy Basil	1	1
Hyaluronic Acid	1	1
Kaempferol	1	1
Lotus	1	1
MSM (Methylsulfonylmethane)	1	1
NAC (N-acetyl-L-cysteine)	1	1
Nobiletin	1	1
Oleuropein	1	1
Peony	1	1
Piperine	1	1
Proanthocyanidins	1	1
Propolis: Brazillian	1	1
Rosmarinic acid	1	1
S-Adenosylmethionine (SAMe)	1	1
Sandalwood	1	1
Sweet Potato	1	1
Tannic Acid	1	1
Tanshinone IIA	1	1
Thymoquinone	1	1
Vitamin A	1	1
acetyl-11-keto-beta-boswellic acid	1	1
beta-Carotene	1	1

Name	AC	CK
Meat	1	10
Morphine	1	2
Organophosphate Pesticides	1	1

Name	AC	CK
Photobiomodulation	35	241
Hyperbaric Treatment	2	30
Light Therapy: Red Colored	2	20
Acupuncture	1	10
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Dietary Modification: Mediterranean Diet	1	10
Infrared Light	1	10
Photodynamic therapy	3	3
Light Therapy: Colored	1	1

Name	AC	CK	Focus
Radiotherapy	3	13
Mobile Phone Radiation	1	5

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Efficacy of photobiomodulation therapy in the management of oral mucositis in patients with head and neck cancer.Mar 31, 2024

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Pubmed Data : Head Neck. 2024 Apr ;46(4):936-950. Epub 2024 Jan 24. PMID: 38265122

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2017 Jul 27. Epub 2017 Jul 27. PMID: 28751477

Article Published Date : Jul 26, 2017

Study Type : Human Study

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Substances : Coffee

Diseases : Breast Cancer, Cancer Mortality, Cancers: All, Colorectal Cancer, Head and Neck Cancer, Liver Cancer

Pharmacological Actions : Chemopreventive

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Dietary patterns that emphasize a high intake of antioxidant and anti-inflammatory bioactive components may have a protective effect on the risk of HNC.Jun 22, 2023

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Pubmed Data : Radiother Oncol. 2012 Sep ;104(3):349-54. Epub 2012 Aug 10. PMID: 22884841

Article Published Date : Aug 31, 2012

Study Type : Human Study

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Diseases : Head and Neck Cancer, Oral Mucositis

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Chemotherapeutic

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Low-level laser therapy for the prevention of low salivary flow rate after radiotherapy and chemotherapy in patients with head and neck cancer.Dec 31, 2015

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Pubmed Data : Adv Radiat Oncol. 2023 ;8(4):101216. Epub 2023 Mar 10. PMID: 37213482

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Diseases : Chemotherapy and Radiation Toxicity, Head and Neck Cancer, Oral Mucositis

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic

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PBMT represents a minimally invasive, prophylactic intervention to decrease OM as a major treatment-related side effect.Nov 30, 2022

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Pubmed Data : World J Otorhinolaryngol Head Neck Surg. 2022 Dec ;8(4):345-354. Epub 2022 Jul 14. PMID: 36474663

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Pubmed Data : Eur J Cancer Prev. 2016 Aug 1. Epub 2016 Aug 1. PMID: 27483412

Article Published Date : Jul 31, 2016

Study Type : Human Study

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Diseases : Head and Neck Cancer

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

Zataria mouthwash effectively decreases the severity of oral mucositis and mouth pain in patients with head and neck cancer treated with radiotherapy.Jun 30, 2018

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Pubmed Data : Clin Oral Investig. 2018 Jul ;22(6):2263-2272. Epub 2018 Jan 8. PMID: 29313134

Article Published Date : Jun 30, 2018

Study Type : Human Study

Additional Links

Substances : Zataria multiflora

Diseases : Head and Neck Cancer, Radiation Induced Illness: Mucositis

Pharmacological Actions : Radioprotective

Additional Keywords : Plant Extracts

[+]

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

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Pubmed Data : Phytother Res. 2017 Nov 23. Epub 2017 Nov 23. PMID: 29168275

Article Published Date : Nov 22, 2017

Study Type : In Vitro Study

Additional Links

Substances : 6-Shogaol

Diseases : Head and Neck Cancer

Pharmacological Actions : Apoptotic, Radiosensitizer

[+]

808-nm photobiomodulation affects the viability of a head and neck squamous carcinoma.Nov 17, 2021

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Pubmed Data : Biomedicines. 2021 Nov 18 ;9(11). Epub 2021 Nov 18. PMID: 34829946

Article Published Date : Nov 17, 2021

Study Type : In Vitro Study

Additional Links

Diseases : Head and Neck Cancer

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Apoptotic

[+]

A phenolic-rich extract of L. barbarum fruits has promising properties against oral and oropharyngeal HPV lesions.Jun 01, 2022

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Pubmed Data : Molecules. 2022 Jun 2 ;27(11). Epub 2022 Jun 2. PMID: 35684505

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Pubmed Data : Nutr Cancer. 2020 Apr 14:1-15. Epub 2020 Apr 14. PMID: 32285707

Article Published Date : Apr 13, 2020

Study Type : Review

Additional Links

Substances : Curcumol

Diseases : Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Anticancer potential of selected flavonols: fisetin, kaempferol, and quercetin on head and neck cancers.Mar 04, 2021

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Pubmed Data : Nutrients. 2021 Mar 5 ;13(3). Epub 2021 Mar 5. PMID: 33807530

Article Published Date : Mar 04, 2021

Study Type : Review

Additional Links

Substances : Fisetin, Quercetin

Diseases : Head and Neck Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Artesunate and cisplatin synergistically inhibit HNSCC cell growth and promote apoptosis.Jul 31, 2023

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Pubmed Data : Oncol Rep. 2023 Aug ;50(2). Epub 2023 Jun 23. PMID: 37350399

Combination of photodynamic therapy and Sulforaphane led to enhanced cytotoxic effect on head and neck cancer cells.Dec 31, 2014

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Pubmed Data : Gen Physiol Biophys. 2015 Jan ;34(1):13-21. Epub 2014 Nov 14. PMID: 25395599

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Pubmed Data : Eur J Cancer. 2013 Oct ;49(15):3210-8. Epub 2013 Jul 19. PMID: 23876835

Article Published Date : Sep 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Epigallocatechin Gallate (EGCG) inhibits tumor growth of head and neck cancer cells.Mar 04, 2023

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Pubmed Data : Asian Pac J Cancer Prev. 2020 Feb 1 ;21(2):363-370. Epub 2020 Feb 1. PMID: 32102512

Article Published Date : Jan 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Head and Neck Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Ethanolic extract of Ocimum sanctum leaf modulates oxidative stress, cell cycle and apoptosis in head and neck cancer cell lines.Mar 31, 2023

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Pubmed Data : Heliyon. 2023 Apr ;9(4):e15518. Epub 2023 Apr 14. PMID: 37128326

Article Published Date : Mar 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Basil

Diseases : Head and Neck Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Gene targets of sulforaphane in head and neck squamous cell carcinoma.Nov 30, 2019

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Pubmed Data : Mol Med Rep. 2019 Dec ;20(6):5335-5344. Epub 2019 Oct 23. PMID: 31661135

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Pubmed Data : Molecules. 2016 Nov 24 ;21(12). Epub 2016 Nov 24. PMID: 27886147

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Pubmed Data : J Clin Biochem Nutr. 2019 Mar ;64(2):97-105. Epub 2018 Oct 13. PMID: 30936621

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Head and Neck Cancer

Pharmacological Actions : Apoptotic

[+]

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Pubmed Data : Photodiagnosis Photodyn Ther. 2021 Mar 9:102253. Epub 2021 Mar 9. PMID: 33711532

Article Published Date : Mar 08, 2021

Study Type : In Vitro Study

Additional Links

Substances : Emodin

Diseases : Head and Neck Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Molecular aspects of piperine in signaling pathways associated with inflammation in head and neck cancer.May 24, 2024

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2023 Jul 31 ;69(7):1-6. Epub 2023 Jul 31. PMID: 37715445

Article Published Date : Jul 30, 2023

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Head and Neck Cancer

Pharmacological Actions : Anti-metastatic

[+]

Oleuropein inhibits invasion of squamous cell carcinoma of the head and neck through TGF-β1 signaling pathway.Aug 31, 2022

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Pubmed Data : Anticancer Res. 2020 Feb ;40(2):751-758. PMID: 32014917

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Pubmed Data : Int J Oncol. 2015 Sep ;47(3):1111-20. Epub 2015 Jul 21. PMID: 26202061

Article Published Date : Aug 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Tannic Acid

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest

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The antioxidant activity and induction of apoptotic cell death by Musa paradisiaca and Trigona sp. honey jelly in ORL115 and ORL188 cells.Jan 31, 2023

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Pubmed Data : Malays J Med Sci. 2023 Feb ;30(1):82-91. Epub 2023 Feb 28. PMID: 36875196

Article Published Date : Jan 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Banana, Honey

Diseases : Head and Neck Cancer

Pharmacological Actions : Antioxidants, Apoptotic

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These data suggest that licochalcone-A has potential chemopreventive effects.Feb 28, 2015

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Pubmed Data : Food Chem Toxicol. 2015 Mar ;77:34-43. Epub 2015 Jan 5. PMID: 25572524

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Licorice

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic

Additional Keywords : Plant Extracts

[+]

This review covers the literature that deals with the anticancer mechanism of resveratrol.Dec 20, 2016

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Pubmed Data : Crit Rev Food Sci Nutr. 2016 Dec 21:0. Epub 2016 Dec 21. PMID: 28001084

Article Published Date : Dec 20, 2016

Study Type : Review

Additional Links

Substances : Resveratrol

Diseases : Bladder Cancer, Breast Cancer, Cancers: All, Cervical Cancer, Colon Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Lung Cancer, Ovarian Cancer, Prostate Cancer

Pharmacological Actions : Antioxidants, Chemopreventive

[+]

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.Jun 30, 2017

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Pubmed Data : Oncol Lett. 2017 Jul ;14(1):1147-1151. Epub 2017 May 17. PMID: 28693287

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Pubmed Data : Invest New Drugs. 2021 Oct 6. Epub 2021 Oct 6. PMID: 34613571

Article Published Date : Oct 05, 2021

Study Type : In Vitro Study

Additional Links

Diseases : Head and Neck Cancer, Skin Cancer: Squamous Cell

Pharmacological Actions : Apoptotic, Radiosensitizer

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α- and β-Santalols directly interact with tubulin and cause mitotic arrest and cytotoxicity in oral cancer cells.Jun 25, 2015

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Pubmed Data : J Nat Prod. 2015 Jun 26 ;78(6):1357-62. Epub 2015 May 20. PMID: 25993496

Article Published Date : Jun 25, 2015

Study Type : In Vitro Study

Additional Links

Substances : Sandalwood

Diseases : Head and Neck Cancer, Oral Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Essential Oils

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Head and Neck Cancer is a Sub of the following Topic

View the Evidence: 189 Abstracts with Head and Neck Cancer Research

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Efficacy of photobiomodulation therapy in the management of oral mucositis in patients with head and neck cancer.Mar 31, 2024

Photobiomodulation in oral mucositis in patients with head and neck cancer.Nov 30, 2020

Curcumin is a safe, natural bioactive substance that can effectively prevent and treat oral mucositis.Dec 31, 2020

Hyperbaric oxygenation for tumour sensitisation to radiotherapy.Jan 10, 2018

Oral administration of honey after radiotherapy could prevent moderate to severe mucositis and associated weight loss.Mar 15, 2015

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer.Dec 31, 2018

Acupuncture for chronic radiation-induced xerostomia in head and neck cancer.Apr 30, 2024

Adherence of head and neck cancer patients to laser photobiomodulation in a public health service.Apr 30, 2021

Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis.Dec 31, 2014

Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis in patients with head-and-neck cancer.Dec 31, 2023

An extract of Glycyrrhiza can be effective for decreasing the severity of oral mucositis in head and neck cancer patients undergoing radiotherapy.Aug 31, 2017

Application of red light phototherapy in the treatment of radioactive dermatitis in patients with head and neck cancer.Nov 11, 2018

Assessment of oxidative stress in tumors and histologically normal mucosa from patients with head and neck squamous cell carcinoma: a preliminary study.Mar 11, 2013

Chamomile gel versus urea cream to prevent acute radiation dermatitis in head and neck cancer patients.Dec 31, 2019

Coffee drinking is associated with a lower risk of colorectal, liver, female breast and head and neck cancer.Jul 26, 2017

Dietary patterns that emphasize a high intake of antioxidant and anti-inflammatory bioactive components may have a protective effect on the risk of HNC.Jun 22, 2023

Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients.Apr 30, 2013

Effectiveness of photobiomodulation on treatment of oral mucositis.Feb 28, 2025

Epigallocatechin-3-gallate mouthwash protects mucosa from radiation-induced mucositis in head and neck cancer patients.Dec 31, 2019

Glutamine significantly decreased mucositis severity in the oral cavity, pharynx and larynx induced by chemoradiotherapy.Oct 22, 2014

Green tea polyphenon E and erlotinib combination was well tolerated in patients with APLs of the head and neck.Jan 14, 2020

Higher dietary fiber intake, prior to the initiation of treatment, may prolong survival time, in those with a new head and neck cancer diagnosis.Sep 26, 2019

LLL seems to be an efficient tool for mitigation of salivary hypofunction in patients undergoing radiochemotherapy for head and neck cancer.Jul 31, 2016

Long-term survival of cancer patients after photobiomodulation therapy for prevention and treatment of oral mucositis.Jul 31, 2024

Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients.Aug 31, 2012

Low-level laser therapy for the prevention of low salivary flow rate after radiotherapy and chemotherapy in patients with head and neck cancer.Dec 31, 2015

Low-level laser therapy in the management of oral mucositis induced by radiotherapy.Dec 31, 2021

Low-level laser therapy seems to be effective to mitigate salivary hypofunction and increase salivary pH of patients submitted to radiotherapy.Mar 02, 2017

Moderate marijuana use is associated with reduced risk of head and neck squamous cell carcinoma.Aug 01, 2009

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

PBM had a preventive effect on stimulated saliva and subjective xerostomia and can be recommended as an adjunctive treatment.Dec 31, 2023

PBM may have a role in decreasing complications related to RT and CRT for HNC, mainly mucositis severity.Dec 31, 2022

PBMT represents a minimally invasive, prophylactic intervention to decrease OM as a major treatment-related side effect.Nov 30, 2022

Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival.Nov 01, 2010

Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients.Oct 31, 2013

Photobiomodulation for the management of xerostomia and oral mucositis in patients with cancer.Apr 14, 2023

Photobiomodulation reduces the impact of radiotherapy on oral health.Oct 27, 2020

Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients.Apr 30, 2021

Processed meat intake was positively associated with head-neck cancer.May 31, 2017

Prophylactic use of an aloe vera-based cream-based cream is thus effective in delaying radiation dermatitis in head and neck cancer.Jun 23, 2017

Protective effect of Punica granatum extract in head and neck cancer patients undergoing radiotherapy.Sep 30, 2019

Tea consumption may protect against the development of second esophageal neoplasms among head and neck squamous-cell carcinoma patients.Mar 18, 2019

The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients.Mar 31, 2017

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study.Oct 30, 2013

The ketogenic diet let to a decline in the lactate concentration in tumor tissue.Dec 31, 2012

The Mediterranean diet acts protectively against head and neck cancer overall and by cancer subsite.Jul 31, 2016

The study provided evidence on the positive effect of thyme honey on the management of radiation-induced oral mucositis.May 31, 2018

These findings provide evidence of the protective role of dietary folate intake on head and neck cancer risk.Nov 20, 2017

These findings support evidence of a protective role of dietary fiber on head and neck cancer risk.Jan 28, 2019

These results indicate that flavonoid intake is associated with lower head and neck cancer risk.Jul 18, 2017

This population-based study did not find a statistically significant increase in the risk of head and neck cancer in young adults from cannabis use.Feb 29, 2008

This study indicates the feasibility of combining hyperbaric oxygen with chemoradiation.Feb 28, 2017

This study showed an inverse association between intake of vitamin C and the incidence of HNC and HNC-subtypes.Jul 07, 2015

This study shows the usefulness of combining iodine with Amla in mitigating radiation-induced mucositis.Nov 30, 2022

Turmeric extract reduces the incidence and severity of radiation-induced mucositis.Feb 06, 2020

Variation of energy in photobiomodulation for the control of radiotherapy-induced oral mucositis.Dec 31, 2017

Zataria mouthwash effectively decreases the severity of oral mucositis and mouth pain in patients with head and neck cancer treated with radiotherapy.Jun 30, 2018

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

This investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion.May 12, 2018

Holistic care approach for the effective management of severe radiation dermatitis using neem and honey.Sep 30, 2020

Photobiomodulation therapy: management of mucosal necrosis of the oropharynx in previously treated head and neck cancer patients.Mar 31, 2017

Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention.Dec 31, 2021

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.Jan 25, 2020

Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus.Feb 29, 2012

Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma. Oct 01, 2010

Curcumin is a potential radio-enhancer in head and neck cancer.Oct 01, 2009

Curcumin suppresses growth of head and neck squamous cell carcinoma.Oct 01, 2005

Curcumin suppresses the growth of head and neck squamous cell cancer. Oct 01, 2008

Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors.Feb 15, 2018

Deguelin may represent a novel and effective chemo-agent against head and neck squamous cell carcinoma.Dec 31, 2012

Diallyl trisulfide induces ROS-mediated mitotic arrest and apoptosis and inhibits HNSCC tumor growth and cancer stemness.Jan 15, 2024

Effect of vitamin B17 (amygdalin) found in apricot kernel on the irradiated salivary glands of albino rats.Dec 31, 2022

Head and Neck Cancer

View the Evidence:
189 Abstracts with Head and Neck Cancer Research