Hyperalgesia

Name	AC	CK
Palmitoylethanolamide	4	16
Cannabidiol	6	11
Cannabis	5	10
Curcumin	5	10
Cannabinoids	3	6
Devils Claw	3	6
Acorus calamus	2	4
Andrographis	2	4
Berberine	2	4
Beta-Caryophyllene	2	4
Black Raspberry	2	4
Catechin	2	4
Crocin	2	4
Diosmin	2	4
Flavonoids	2	4
Fucoidan	2	4
Paeoniflorin	2	4
Thiamine (B-1)	2	4
Verbascoside	2	4
Tanshinone IIA	2	3
Alpha-Lipoic Acid	1	2
Apigenin	1	2
Ayahuasca	1	2
Bacopa	1	2
Bee Venom	1	2
Bergamot	1	2
Betulinic acid	1	2
Cardamonin	1	2
Carnitine	1	2
Chinese Skullcap	1	2
Chrysin	1	2
Citrus naringin	1	2
Coenzyme Q10	1	2
Coffee	1	2
Diosgenin	1	2
Dogwood	1	2
Ellagic Acid	1	2
Emodin	1	2
Gastrodin	1	2
Genistein	1	2
Gotu Kola	1	2
Grape	1	2
Grape Seed Extract	1	2
Harmine	1	2
Honokiol	1	2
Hydrogen Water	1	2
Icariin	1	2
Japanese cypress	1	2
Magnesium Sulfate	1	2
Mangiferin	1	2
Melatonin	1	2
Nobiletin	1	2
Olive leaf extract	1	2
Orange: Mandarin	1	2
Oridonin	1	2
Palash	1	2
Patchouli	1	2
Piperidines	1	2
Puerarin	1	2
Resveratrol	1	2
Rhodiola (Tibetan Ginseng)	1	2
Rhubarb	1	2
Rosemary	1	2
Sinomenine	1	2
Terminalia chebula	1	2
Ursolic Acid	1	2
Vitamin B-12	1	2
Vitamin B-6	1	2
Vitamin C	1	2
Vitamin E	1	2
Vitexins	1	2
Paeonol	1	1
Sulforaphane	1	1

Name	AC	CK	Focus
Monosodium Glutamate (MSG)	1	2
Morphine	1	2

Name	AC	CK
Electroacupuncture	3	6
Laser Treatment: Low-Level	1	2
Light Therapy: Red Colored	1	2

Name	AC	CK	Focus
Nocebo Effect	3	21
Vaccination: HPV (Gardasil)	1	10

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Nocebo-induced hyperalgesia during local anesthetic injection.Mar 01, 2010

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Pubmed Data : Anesth Analg. 2010 Mar 1;110(3):868-70. Epub 2009 Dec 30. PMID: 20042440

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Diseases : Hyperalgesia

Anti Therapeutic Actions : Nocebo Effect

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The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers.Sep 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Oct 1 ;14(19). Epub 2022 Oct 1. PMID: 36235736

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2012 Aug ;385(8):807-22. Epub 2012 May 11. PMID: 22573016

Article Published Date : Jul 31, 2012

Study Type : Animal Study

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Substances : Catechin

Diseases : Hyperalgesia, Sciatic Nerve Crush Injury

Pharmacological Actions : Apoptotic, Neuroprotective Agents

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Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID: 22195029

Article Published Date : Dec 31, 2010

Study Type : Animal Study

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Substances : Vitamin C, Vitamin E

Diseases : Hyperalgesia, Inflammation, Peripheral Neuropathies

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Natural Substance Synergy

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Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve.Aug 31, 2022

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Pubmed Data : Phytother Res. 2022 Sep ;36(9):3644-3661. Epub 2022 Aug 17. PMID: 35976195

Article Published Date : Aug 31, 2022

Study Type : Animal Study

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Substances : Nobiletin

Diseases : Hyperalgesia, Neuropathic Pain

Pharmacological Actions : Analgesics

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Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Funct Neurol. 2016 Jan-Mar;31(1):53-60. PMID: 27027895

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Andrographis

Diseases : Headache: Migraine, Hyperalgesia

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-6 Downregulation

Additional Keywords : Plant Extracts

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Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

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Pubmed Data : Pharm Biol. 2018 Dec ;56(1):124-131. PMID: 29385888

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Andrographis

Diseases : Allodynia, Hyperalgesia

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

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Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy.Oct 05, 2022

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Pubmed Data : Sci Rep. 2022 Oct 6 ;12(1):16730. Epub 2022 Oct 6. PMID: 36202956

Article Published Date : Oct 05, 2022

Study Type : Animal Study

Additional Links

Diseases : Diabetic Neuropathy, Hyperalgesia

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Toxicol Ind Health. 2013 Feb ;29(1):3-13. Epub 2012 Jan 27. PMID: 22287618

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

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Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Medicina (Kaunas). 2023 Jan 30 ;59(2). Epub 2023 Jan 30. PMID: 36837466

Article Published Date : Jan 29, 2023

Study Type : Animal Study

Additional Links

Substances : Black Raspberry

Diseases : Hyperalgesia, Postoperative Recovery

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-6 Downregulation

Additional Keywords : Plant Extracts

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Effect of ultra-Micronized-palmitoylethanolamide and acetyl-l-carnitine on experimental model of inflammatory pain.Feb 16, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mol Pain. 2024 ;20:17448069241240692. PMID: 38443317

Article Published Date : Dec 31, 2023

Study Type : Animal Study

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Diseases : Cancer: Pain , Cancers: All, Hyperalgesia

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Analgesics, Chemotherapeutic

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Electroacupuncture induces antihyperalgesic effect through endothelin-B receptor in the chronic phase of a mouse model of complex regional pain syndrome type I.Jan 12, 2018

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Pubmed Data : Pflugers Arch. 2018 12 ;470(12):1815-1827. Epub 2018 Aug 10. PMID: 30094478

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2014 ;19(1):1060-8. Epub 2014 Jan 16. PMID: 24441655

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Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Feb ;33(2):155-8. PMID: 29762002

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Hyperalgesia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Icariin ameliorates lower back pain.Dec 31, 2019

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Pubmed Data : Pharmacology. 2017 ;100(3-4):172-187. Epub 2017 Jul 1. PMID: 28668949

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Cerebral Hemorrhage, Hyperalgesia, Lipid Peroxidation

Pharmacological Actions : Neuroprotective Agents, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Neuroprotective effect of saponin rich extract of Acorus calamus.Jul 31, 2012

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Pubmed Data : J Ethnopharmacol. 2012 Aug 1 ;142(3):723-31. Epub 2012 Jun 15. PMID: 22706151

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Pubmed Data : Neural Regen Res. 2018 Jul ;13(7):1263-1268. PMID: 30028336

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Allodynia, Hyperalgesia, Peripheral Nerve Diseases

Pharmacological Actions : Analgesics

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R. rosea ethanol extract may have potential as a treatment for diabetic hyperalgesia. Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Japanese cypress

Diseases : Hyperalgesia, Pain

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive

Additional Keywords : Essential Oils

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These data strongly support grape seed extract as an effective therapeutic approach in multiple sclerosis treatment.Dec 31, 2021

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Pubmed Data : Front Immunol. 2022 ;13:960355. Epub 2022 Aug 17. PMID: 36059517

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Hyperalgesia, Inflammation, Multiple Sclerosis

Pharmacological Actions : Antioxidants

[+]

These results demonstrate that TRPV1 receptor could be a molecular target of the CBD antihyperalgesic action.Aug 31, 2004

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Pubmed Data : Pain Physician. 2015 Jul-Aug;18(4):E615-28. PMID: 26218952

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hyperalgesia, Pancreatitis

Pharmacological Actions : Antinoceceptive

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There are neurobiological mechanisms that may explain the hyperanalgesic consequences of the nocebo effect.Jun 29, 2007

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Pubmed Data : Neuroscience. 2007 Jun 29;147(2):260-71. Epub 2007 Mar 26. PMID: 17379417

Article Published Date : Jun 29, 2007

Study Type : Commentary

Additional Links

Diseases : Hyperalgesia

Anti Therapeutic Actions : Nocebo Effect

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View the Evidence: 118 Abstracts with Hyperalgesia Research

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A disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.Oct 31, 2015

Nocebo-induced hyperalgesia during local anesthetic injection.Mar 01, 2010

The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers.Sep 30, 2022

Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors.Sep 01, 2009

Therapeutic effect of melittin on a rat model of chronic prostatitis induced by complete freund's adjuvant.May 31, 2017

"(-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury."Jul 31, 2012

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve.Aug 31, 2022

Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.Dec 31, 2015

Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy.Oct 05, 2022

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.Jan 10, 2019

Anti-hyperalgesic properties of ethanolic crude extract from the peels of Citrus reticulate.Dec 31, 2019

Anti-nociceptive effect of patchouli alcohol.May 31, 2019

Antihyperalgesic activity of verbascoside in two models of neuropathic pain.Mar 31, 2011

Antinociceptive action of cannabidiol on thermal sensitivity and post-operative pain.Feb 28, 2024

Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model.Jan 31, 2013

Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain.Jan 31, 2017

Apigenin alleviates allodynia and hyperalgesia in a mouse model of chemotherapy-induced peripheral neuropathy.May 07, 2023

Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain.Apr 05, 2024

Bacopa monnieri can be used as adjuvant therapy for neuropathic pain conditions afflicted with allodynia and hyperalgesia.Jun 04, 2017

Baicalin, a compound found within Chinese skullcap, is as effective as ibuprofen as an analgesic in an experiemental model of hyperalgesia. Dec 01, 2003

Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

Beta-caryophyllene may be highly effective in the treatment of debilitating pain states.Mar 31, 2014

Betulinic acid alleviates neuropathic pain induced by chronic constriction injury of the sciatic nerve.Sep 13, 2023

Black raspberry extract showed antinociceptive activity against induced chronic muscle pain.Jul 10, 2016

Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice.Sep 30, 2022

Cannabinoids demonstrated antinociceptive effects in this mouse model of diabetic peripheral neuropathy.Mar 16, 2010

Cannabis sativa extract has an antihyperalgesic effect in a rat model of neuropathic pain.Jul 31, 2008

Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain.Feb 04, 2017

Centella asiatica (L.) Urban leaves demonstrated promising anti-nociceptive effects in animal models of migraine.Mar 31, 2015

Chronic administration of resveratrol attenuates inflammation-induced mechanical hyperalgesia.Jan 31, 2016

Chronic monosodium glutamate administration induced hyperalgesia in mice.Dec 20, 2017

Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy.Apr 24, 2023

Co-administration Bergamot polyphenolic fractions can be an important therapeutic approach to restore opioids analgesic efficacy.Dec 31, 2015

Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia.Aug 31, 2018

Crocin could attenuate hyperalgesia induced by sleep deprivation.Apr 30, 2020

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.Nov 05, 2015

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.May 01, 2006

Curcumin has antihyperalgesic properties. Feb 01, 2010

Curcumin was found to have anti-hyperalgesic activity by decreasing oxidative stress and down regulation of inflammatory cytokines. Feb 28, 2015

Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury.Jul 31, 2017

Diosgenin exerts analgesic effects in a mouse model of neuropathic pain.Dec 12, 2022

Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway.Dec 31, 2023

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice.Jul 31, 2017

Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy.Mar 31, 2011

Effect of immature Rubus occidentalis on postoperative pain in a rat model. Jan 29, 2023

Effect of ultra-Micronized-palmitoylethanolamide and acetyl-l-carnitine on experimental model of inflammatory pain.Feb 16, 2021

Electroacupuncture alleviates diabetes-induced mechanical allodynia and downregulates bradykinin B1 receptor expression in spinal cord dorsal horn.Aug 06, 2024

Electroacupuncture at different frequencies improves visceral pain in IBS rats through different pathways.Jul 18, 2024

Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex.May 28, 2024

Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain.Dec 31, 2023

Electroacupuncture induces antihyperalgesic effect through endothelin-B receptor in the chronic phase of a mouse model of complex regional pain syndrome type I.Jan 12, 2018

Electroacupuncture promotes macrophage/microglial M2 polarization and suppresses inflammatory pain.Apr 02, 2024

Emodin alleviates chronic constriction injury-induced neuropathic pain and inflammation.Dec 31, 2022

Escin alleviates chemotherapy-induced peripheral neuropathic pain.Nov 29, 2020

Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain.Jun 12, 2014

Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy.Dec 31, 2011

Genistein reverses the effect of 17β-estradiol on exacerbating experimental occlusal interference-induced chronic masseter hyperalgesia.Jun 01, 2021

H. procumbens cooperates synergistically with morphine in resolving hyperalgesia and allodynia.May 31, 2016

H. procumbens extracts have potential analgesic effects in the case of acute postoperative pain and chronic neuropathic pain in rats.Dec 31, 2013

High-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology.Aug 31, 2022

Honokiol has a significant anti-nociceptive activity through inhibition of anti-inflammatory mediators.Dec 31, 2017

Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia.Jan 31, 2017

Icariin ameliorates lower back pain.Dec 31, 2019

Inhibitory effect of berberine on morphine tolerance and hyperalgesia.Sep 30, 2023

Loganin prevents chronic constriction injury-provoked neuropathic pain.Jan 31, 2020

Low-level laser therapy (LLLT) reduces the COX-2 mRNA expression in both subplantar and total brain tissues in the model of peripheral inflammation.Jun 30, 2014

Mangiferin has anti-inflammatory and analgesic properties when locally administrated.Jul 04, 2018

Mechanical hypersensitivity was inhibited by the antioxidative drug α-lipoic acid.Dec 31, 2021

Mechanism of electroacupuncture analgesia on nicotine withdrawal-induced hyperalgesia.Dec 31, 2021

Melatonin is a potential means for countering hyperalgesia induced by neonatal morphine exposure in young and adult rats.Aug 17, 2016

Hyperalgesia

View the Evidence:
118 Abstracts with Hyperalgesia Research