Hyperalgesia

Name	AC	CK
Palmitoylethanolamide	5	18
Cannabidiol	7	13
Curcumin	6	13
Cannabis	5	10
Cannabinoids	4	8
Catechin	3	6
Devils Claw	3	6
Acorus calamus	2	4
Andrographis	2	4
Berberine	2	4
Beta-Caryophyllene	2	4
Black Raspberry	2	4
Crocin	2	4
Diosgenin	2	4
Diosmin	2	4
Flavonoids	2	4
Fucoidan	2	4
Paeoniflorin	2	4
Thiamine (B-1)	2	4
Verbascoside	2	4
Tanshinone IIA	2	3
Alpha-Lipoic Acid	1	2
Apigenin	1	2
Ayahuasca	1	2
Bacopa	1	2
Bee Venom	1	2
Bergamot	1	2
Betulinic acid	1	2
Cannabigerol	1	2
Cardamonin	1	2
Carnitine	1	2
Chinese Skullcap	1	2
Chrysin	1	2
Citicoline	1	2
Citrus naringin	1	2
Coenzyme Q10	1	2
Coffee	1	2
Diosmetin	1	2
Dogwood	1	2
Ellagic Acid	1	2
Emodin	1	2
Gastrodin	1	2
Genistein	1	2
Gotu Kola	1	2
Grape	1	2
Grape Seed Extract	1	2
Harmine	1	2
Honokiol	1	2
Horse Chestnut	1	2
Hydrogen Water	1	2
Icariin	1	2
Japanese cypress	1	2
Leonurine	1	2
Magnesium Sulfate	1	2
Mangiferin	1	2
Melatonin	1	2
Nobiletin	1	2
Olive leaf extract	1	2
Orange: Mandarin	1	2
Oridonin	1	2
Palash	1	2
Patchouli	1	2
Piperidines	1	2
Puerarin	1	2
Resveratrol	1	2
Rhodiola (Tibetan Ginseng)	1	2
Rhubarb	1	2
Rosemary	1	2
Rubia Cordifolia	1	2
Sinomenine	1	2
Terminalia chebula	1	2
Ursolic Acid	1	2
Vanillic Acid	1	2
Vitamin B-12	1	2
Vitamin B-6	1	2
Vitamin C	1	2
Vitamin E	1	2
Vitexins	1	2
Angelica	1	1
Baicalein	1	1
Carrageenans	1	1
Paeonol	1	1
Sulforaphane	1	1

Name	AC	CK
Monosodium Glutamate (MSG)	1	2
Morphine	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2

Name	AC	CK
Photobiomodulation	33	74
Electroacupuncture	9	18
Hyperbaric Treatment	2	14
Infrared Light	3	6
Dietary Modification: Low Carbohydrate/Ketogenic	2	4
Exercise	2	4
Light Therapy: Red Colored	2	4
Exercise: Swimming	1	2
Transcutaneous electrical nerve stimulation (TENS)	1	2

Name	AC	CK	Focus
Nocebo Effect	3	21
Vaccination: HPV (Gardasil)	1	10

[+]

Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia.Aug 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Pain. 2012 Sep ;16(8):1094-105. PMID: 22354664

Article Published Date : Aug 31, 2012

Study Type : Animal Study, Human Study

Additional Links

Diseases : Hyperalgesia, Trigeminal Neuralgia

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Neuroprotective Agents

[+]

A disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.Oct 31, 2015

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Pubmed Data : Clin Rheumatol. 2015 Nov ;34(11):1981-3. Epub 2015 Sep 10. PMID: 26354426

Article Published Date : Oct 31, 2015

Study Type : Human Study

Additional Links

Diseases : Fatigue, Fibromyalgia, Hyperalgesia, Neuropathic Pain, Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: HPV (Gardasil)

[+]

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pain Rep. 2021 ;6(4):e968. Epub 2021 Dec 8. PMID: 34901678

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Diseases : Allodynia, Chronic Pain, Hyperalgesia

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Analgesics

[+]

Nocebo-induced hyperalgesia during local anesthetic injection.Mar 01, 2010

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Pubmed Data : Anesth Analg. 2010 Mar 1;110(3):868-70. Epub 2009 Dec 30. PMID: 20042440

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Diseases : Hyperalgesia

Anti Therapeutic Actions : Nocebo Effect

[+]

The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers.Sep 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Oct 1 ;14(19). Epub 2022 Oct 1. PMID: 36235736

Article Published Date : Sep 30, 2022

Study Type : Human Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Hyperalgesia

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors.Sep 01, 2009

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Pubmed Data : Neuroimage. 2009 Sep;47(3):995-1001. Epub 2009 Apr 16. PMID: 19375508

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hyperalgesia, Irritable Bowel Syndrome

Anti Therapeutic Actions : Nocebo Effect

[+]

Curcumin relieves CFA-induced inflammatory pain.Dec 31, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Neurol. 2018 Aug ;306:149-157. Epub 2018 May 17. PMID: 29763602

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Diseases : High Fat Diet, Hyperalgesia, Metabolic Diseases, Prediabetes

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Neuritogenic

Additional Keywords : Nerve Regeneration

[+]

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

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Pubmed Data : PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID: 22195029

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Pubmed Data : Funct Neurol. 2016 Jan-Mar;31(1):53-60. PMID: 27027895

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Andrographis

Diseases : Headache: Migraine, Hyperalgesia

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-6 Downregulation

Additional Keywords : Plant Extracts

[+]

Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

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Pubmed Data : J Pharm Pharmacol. 2011 Apr ;63(4):594-601. Epub 2011 Mar 8. PMID: 21401613

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Chin J Nat Med. 2015 Apr ;13(4):274-82. PMID: 25908624

Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain.Dec 31, 2023

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Pubmed Data : Neuroreport. 2024 Apr 3 ;35(6):343-351. Epub 2024 Mar 19. PMID: 38526969

Article Published Date : Apr 02, 2024

Study Type : Animal Study

Additional Links

Diseases : Hyperalgesia, Inflammation

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Analgesics

[+]

Emodin alleviates chronic constriction injury-induced neuropathic pain and inflammation.Dec 31, 2022

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Pubmed Data : Photochem Photobiol Sci. 2023 Nov ;22(11):2527-2540. Epub 2023 Oct 3. PMID: 37787959

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2014 ;19(1):1060-8. Epub 2014 Jan 16. PMID: 24441655

Inhibitory effect of berberine on morphine tolerance and hyperalgesia.Sep 30, 2023

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Pubmed Data : J Tradit Chin Med. 2023 Oct ;43(5):915-924. PMID: 37679979

Article Published Date : Sep 30, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Hyperalgesia, Morphine Tolerance/Dependence

Pharmacological Actions : Neuroprotective Agents

[+]

Ketogenic diet has a therapeutic effect on chronic pain induced by inflammation and nerve injury.Dec 31, 2023

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[+]

Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice.Jun 23, 2025

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[+]

Possible role of antioxidative capacity of (-)-epigallocatechin-3-gallate treatment in morphological and neurobehavioral recovery after sciatic nerve crush injury.Nov 01, 2017

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Pubmed Data : J Neurosurg Spine. 2017 Nov ;27(5):593-613. Epub 2017 Aug 4. PMID: 28777065

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Pubmed Data : Front Immunol. 2022 ;13:960355. Epub 2022 Aug 17. PMID: 36059517

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Hyperalgesia, Inflammation, Multiple Sclerosis

Pharmacological Actions : Antioxidants

[+]

These results demonstrate that TRPV1 receptor could be a molecular target of the CBD antihyperalgesic action.Aug 31, 2004

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[+]

Decursin alleviates mechanical allodynia in a paclitaxel-induced neuropathic pain.Mar 03, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cells. 2021 Mar 4 ;10(3). Epub 2021 Mar 4. PMID: 33806325

Article Published Date : Mar 03, 2021

Study Type : In Vitro Study

Additional Links

Substances : Angelica

Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Hyperalgesia

Pharmacological Actions : Neuroprotective Agents

[+]

Expression of mPGES-1 and IP mRNA is reduced by LLLT in both subplantar and brain tissues in the model of peripheral inflammation induced by carrageenan.Dec 31, 2014

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Pubmed Data : Lasers Med Sci. 2015 Jan ;30(1):83-8. Epub 2014 Jun 29. PMID: 24974175

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pain Physician. 2015 Jul-Aug;18(4):E615-28. PMID: 26218952

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hyperalgesia, Pancreatitis

Pharmacological Actions : Antinoceceptive

[+]

There are neurobiological mechanisms that may explain the hyperanalgesic consequences of the nocebo effect.Jun 29, 2007

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Pubmed Data : Neuroscience. 2007 Jun 29;147(2):260-71. Epub 2007 Mar 26. PMID: 17379417

Article Published Date : Jun 29, 2007

Study Type : Commentary

Additional Links

Diseases : Hyperalgesia

Anti Therapeutic Actions : Nocebo Effect

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View the Evidence: 163 Abstracts with Hyperalgesia Research

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Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia.Aug 31, 2012

A disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.Oct 31, 2015

Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model.Dec 31, 2020

Nocebo-induced hyperalgesia during local anesthetic injection.Mar 01, 2010

The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers.Sep 30, 2022

Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors.Sep 01, 2009

Curcumin relieves CFA-induced inflammatory pain.Dec 31, 2024

Photobiomodulation decreases hyperalgesia in complex regional pain syndrome.Oct 31, 2020

Therapeutic effect of melittin on a rat model of chronic prostatitis induced by complete freund's adjuvant.May 31, 2017

"(-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury."Jul 31, 2012

A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth.Jul 31, 2018

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Analgesic effect of Ga-Al-As diode laser irradiation on hyperalgesia in carrageenin-induced inflammation.Dec 31, 1992

Analgesic effect of light-emitting diode (LED) therapy at wavelengths of 635 and 945 nm on Bothrops moojeni venom-induced hyperalgesia.Dec 31, 2013

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve.Aug 31, 2022

Analgesic effect of photobiomodulation on Bothrops moojeni venom-induced hyperalgesia.Sep 30, 2016

Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.Dec 31, 2015

Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy.Oct 05, 2022

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.Jan 10, 2019

Anti-hyperalgesic properties of ethanolic crude extract from the peels of Citrus reticulate.Dec 31, 2019

Anti-inflammatory effect of photobiomodulation in the brain following local peripheral carrageenan-induced inflammation.Jun 10, 2025

Anti-nociceptive effect of patchouli alcohol.May 31, 2019

Antihyperalgesic activity of verbascoside in two models of neuropathic pain.Mar 31, 2011

Antinociceptive action of cannabidiol on thermal sensitivity and post-operative pain.Feb 28, 2024

Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model.Jan 31, 2013

Antinociceptive effect of matrine on vincristine-induced neuropathic pain.May 31, 2014

Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain.Jan 31, 2017

Apigenin alleviates allodynia and hyperalgesia in a mouse model of chemotherapy-induced peripheral neuropathy.May 07, 2023

Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain.Apr 05, 2024

Bacopa monnieri can be used as adjuvant therapy for neuropathic pain conditions afflicted with allodynia and hyperalgesia.Jun 04, 2017

Baicalin, a compound found within Chinese skullcap, is as effective as ibuprofen as an analgesic in an experiemental model of hyperalgesia. Dec 01, 2003

Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

Beta-caryophyllene may be highly effective in the treatment of debilitating pain states.Mar 31, 2014

Betulinic acid alleviates neuropathic pain induced by chronic constriction injury of the sciatic nerve.Sep 13, 2023

Black raspberry extract showed antinociceptive activity against induced chronic muscle pain.Jul 10, 2016

Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice.Sep 30, 2022

Cannabinoids demonstrated antinociceptive effects in this mouse model of diabetic peripheral neuropathy.Mar 16, 2010

Cannabis sativa extract has an antihyperalgesic effect in a rat model of neuropathic pain.Jul 31, 2008

Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain.Feb 04, 2017

Catechin attenuates CCI-induced neuropathic pain.Jul 31, 2024

Centella asiatica (L.) Urban leaves demonstrated promising anti-nociceptive effects in animal models of migraine.Mar 31, 2015

Central involvement of 5-HT1A receptors in antinociception induced by photobiomodulation in animal model of neuropathic pain.Feb 28, 2022

Chronic administration of resveratrol attenuates inflammation-induced mechanical hyperalgesia.Jan 31, 2016

Chronic monosodium glutamate administration induced hyperalgesia in mice.Dec 20, 2017

Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy.Apr 24, 2023

Citicoline enhanced the efficacy of imipramine for the modulation of pain behavior in nerve-ligated mice.Jul 31, 2024

Co-administration Bergamot polyphenolic fractions can be an important therapeutic approach to restore opioids analgesic efficacy.Dec 31, 2015

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury.Jun 23, 2019

Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia.Aug 31, 2018

Combined effect of Cerium oxide nanoparticles loaded scaffold and photobiomodulation therapy on pain and neuronal regeneration following spinal cord injury.Jan 31, 2024

Crocin could attenuate hyperalgesia induced by sleep deprivation.Apr 30, 2020

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.Nov 05, 2015

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.May 01, 2006

Curcumin has antihyperalgesic properties. Feb 01, 2010

Curcumin was found to have anti-hyperalgesic activity by decreasing oxidative stress and down regulation of inflammatory cytokines. Feb 28, 2015

Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury.Jul 31, 2017

Diosgenin exerts analgesic effects in a mouse model of neuropathic pain.Dec 12, 2022

Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway.Dec 31, 2023

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice.Jul 31, 2017

Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy.Mar 31, 2011

Effect of immature Rubus occidentalis on postoperative pain in a rat model. Jan 29, 2023

Effect of low level laser therapy on chronic compression of the dorsal root ganglion.Dec 31, 2013

Effect of NIR laser therapy by MLS-MiS source against neuropathic pain.Jun 25, 2019

Effect of photobiomodulation therapy (808 nm) in the control of neuropathic pain.Apr 30, 2017

Effect of ultra-Micronized-palmitoylethanolamide and acetyl-l-carnitine on experimental model of inflammatory pain.Feb 16, 2021

Effects of 660- and 980-nm low-level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve.Aug 31, 2014

Effects of low-level laser therapy on the modulation of tissue temperature and hyperalgesia following a partial Achilles tendon injury.Oct 31, 2017

Electroacupuncture alleviates diabetes-induced mechanical allodynia and downregulates bradykinin B1 receptor expression in spinal cord dorsal horn.Aug 06, 2024

Electroacupuncture at different frequencies improves visceral pain in IBS rats through different pathways.Jul 18, 2024

Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex.May 28, 2024

Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain.Dec 31, 2023

Hyperalgesia

View the Evidence:
163 Abstracts with Hyperalgesia Research