Hyperalgesia

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51 Substances Researched for Hyperalgesia
NameACCKFocus
Cannabidiol611Locked
Curcumin510Locked
Cannabis48Locked
Cannabinoids 36Locked
Devils Claw36Locked
Beta-Caryophyllene24Locked
Catechin 24Locked
Crocin24Locked
Diosmin 24Locked
Fucoidan24Locked
Paeoniflorin24Locked
Palmitoylethanolamide 24Locked
Thiamine (B-1) 24Locked
Verbascoside24Locked
Tanshinone IIA23Locked
Bacopa12Locked
Bee Venom12Locked
Berberine12Locked
Bergamot12Locked
Black Raspberry12Locked
Cardamonin12Locked
Chinese Skullcap 12Locked
Citrus naringin12Locked
Coenzyme Q1012Locked
Diosgenin12Locked
Dogwood12Locked
Gastrodin12Locked
Gotu Kola12Locked
Honokiol12Locked
Japanese cypress12Locked
Magnesium Sulfate12Locked
Mangiferin12Locked
Melatonin12Locked
Olive leaf extract12Locked
Orange: Mandarin12Locked
Oridonin12Locked
Palash12Locked
Patchouli12Locked
Piperidines12Locked
Puerarin12Locked
Resveratrol12Locked
Rhodiola (Tibetan Ginseng)12Locked
Rhubarb12Locked
Rosemary12Locked
Sinomenine12Locked
Ursolic Acid12Locked
Vitamin B-1212Locked
Vitamin B-612Locked
Vitamin C12Locked
Vitamin E12Locked
Vitexins12Locked
2 Problem Substances Researched for Hyperalgesia
NameACCKFocus
Monosodium Glutamate (MSG)12Locked
Morphine12Locked
1 Therapeutic Actions Researched for Hyperalgesia
NameACCKFocus
Electroacupuncture36Locked
2 Problematic Actions Researched for Hyperalgesia
NameACCKFocus
Nocebo Effect321Locked
Vaccination: HPV (Gardasil)110Locked

View the Evidence:
95 Abstracts with Hyperalgesia Research

[+]

A disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.Oct 31, 2015

Pubmed Data : Clin Rheumatol. 2015 Nov ;34(11):1981-3. Epub 2015 Sep 10. PMID: 26354426
Article Published Date : Oct 31, 2015
Study Type : Human Study
Additional Links
Diseases : Fatigue, Fibromyalgia, Hyperalgesia, Neuropathic Pain, Vaccine-induced Toxicity
Anti Therapeutic Actions : Vaccination: HPV (Gardasil)
[+]

Nocebo-induced hyperalgesia during local anesthetic injection.Mar 01, 2010

Pubmed Data : Anesth Analg. 2010 Mar 1;110(3):868-70. Epub 2009 Dec 30. PMID: 20042440
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Hyperalgesia
Anti Therapeutic Actions : Nocebo Effect
[+]

The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Oct 1 ;14(19). Epub 2022 Oct 1. PMID: 36235736
Article Published Date : Sep 30, 2022
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Hyperalgesia
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors.Sep 01, 2009

Pubmed Data : Neuroimage. 2009 Sep;47(3):995-1001. Epub 2009 Apr 16. PMID: 19375508
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hyperalgesia, Irritable Bowel Syndrome
Anti Therapeutic Actions : Nocebo Effect
[+]

Therapeutic effect of melittin on a rat model of chronic prostatitis induced by complete freund's adjuvant.May 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jun ;90:921-927. Epub 2017 Apr 22. PMID: 28441718
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Hyperalgesia, Inflammation, Prostatitis: Chronic
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

"(-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury."Jul 31, 2012

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2012 Aug ;385(8):807-22. Epub 2012 May 11. PMID: 22573016
Article Published Date : Jul 31, 2012
Study Type : Animal Study
Additional Links
Substances : Catechin
Diseases : Hyperalgesia, Sciatic Nerve Crush Injury
Pharmacological Actions : Apoptotic, Neuroprotective Agents
[+]

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID: 22195029
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin E
Diseases : Hyperalgesia, Inflammation, Peripheral Neuropathies
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Natural Substance Synergy
[+]

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve.Aug 31, 2022

Pubmed Data : Phytother Res. 2022 Sep ;36(9):3644-3661. Epub 2022 Aug 17. PMID: 35976195
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Funct Neurol. 2016 Jan-Mar;31(1):53-60. PMID: 27027895
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Andrographis
Diseases : Headache: Migraine, Hyperalgesia
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-6 Downregulation
Additional Keywords : Plant Extracts
[+]

Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2018 Dec ;56(1):124-131. PMID: 29385888
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Andrographis
Diseases : Allodynia, Hyperalgesia
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy.Oct 05, 2022

Pubmed Data : Sci Rep. 2022 Oct 6 ;12(1):16730. Epub 2022 Oct 6. PMID: 36202956
Article Published Date : Oct 05, 2022
Study Type : Animal Study
Additional Links
Diseases : Diabetic Neuropathy, Hyperalgesia
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.Jan 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2019 09 11 ;20(1):57. Epub 2019 Sep 11. PMID: 31511086
Article Published Date : Jan 10, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Anti-hyperalgesic properties of ethanolic crude extract from the peels of Citrus reticulate.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : An Acad Bras Cienc. 2020 ;92(1):e20180793. Epub 2020 May 11. PMID: 32401835
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Orange: Mandarin
Diseases : Hyperalgesia
Pharmacological Actions : Analgesics
[+]

Anti-nociceptive effect of patchouli alcohol.May 31, 2019

Pubmed Data : Chin J Integr Med. 2019 Jun ;25(6):454-461. Epub 2017 Aug 9. PMID: 28795389
Article Published Date : May 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Patchouli
Diseases : Hyperalgesia
Pharmacological Actions : Analgesics, Antinoceceptive , Cyclooxygenase 2 Inhibitors
[+]

Antihyperalgesic activity of verbascoside in two models of neuropathic pain.Mar 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Pharmacol. 2011 Apr ;63(4):594-601. Epub 2011 Mar 8. PMID: 21401613
Article Published Date : Mar 31, 2011
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy
[+]

Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model.Jan 31, 2013

Pubmed Data : Toxicol Ind Health. 2013 Feb ;29(1):3-13. Epub 2012 Jan 27. PMID: 22287618
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : Palash
Diseases : Hyperalgesia, Oxidative Stress
Pharmacological Actions : Analgesics, Antinoceceptive , Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain.Jan 31, 2017

Pubmed Data : Mol Med Rep. 2017 Feb ;15(2):975-980. Epub 2016 Dec 23. PMID: 28035379
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

Bacopa monnieri can be used as adjuvant therapy for neuropathic pain conditions afflicted with allodynia and hyperalgesia.Jun 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jun 5 ;17(1):293. Epub 2017 Jun 5. PMID: 28583132
Article Published Date : Jun 04, 2017
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Allodynia, Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Antinoceceptive
[+]

Baicalin, a compound found within Chinese skullcap, is as effective as ibuprofen as an analgesic in an experiemental model of hyperalgesia. Dec 01, 2003

Pubmed Data : Anesth Analg. 2003 Dec;97(6):1724-9. PMID: 14633550
Article Published Date : Dec 01, 2003
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap
Diseases : Hyperalgesia, Pain
Pharmacological Actions : Analgesics
Additional Keywords : Baicalin, Ibuprofen Alternatives, Natural Substances Versus Drugs
[+]

Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724
Article Published Date : Apr 09, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Depression, Hyperalgesia, Inflammation
Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Beta-caryophyllene may be highly effective in the treatment of debilitating pain states.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Neuropsychopharmacol. 2014 Apr ;24(4):608-20. Epub 2013 Oct 22. PMID: 24210682
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Black raspberry extract showed antinociceptive activity against induced chronic muscle pain.Jul 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Jul 11 ;16:202. Epub 2016 Jul 11. PMID: 27400712
Article Published Date : Jul 10, 2016
Study Type : Animal Study
Additional Links
Substances : Black Raspberry
Diseases : Hyperalgesia
Pharmacological Actions : Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Oct ;154:113552. Epub 2022 Aug 18. PMID: 35988425
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Cannabis
Diseases : Fibromyalgia, Hyperalgesia
Pharmacological Actions : Analgesics
[+]

Cannabinoids demonstrated antinociceptive effects in this mouse model of diabetic peripheral neuropathy.Mar 16, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pain. 2010 Mar 17 ;6:16. Epub 2010 Mar 17. PMID: 20236533
Article Published Date : Mar 16, 2010
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabinoids
Diseases : Brain: Microglial Activation, Diabetic Neuropathies, Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

Cannabis sativa extract has an antihyperalgesic effect in a rat model of neuropathic pain.Jul 31, 2008

Pubmed Data : Phytother Res. 2008 Aug ;22(8):1017-24. PMID: 18618522
Article Published Date : Jul 31, 2008
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabinoids , Cannabis
Diseases : Hyperalgesia
Pharmacological Actions : Analgesics
Additional Keywords : Plant Extracts
[+]

Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain.Feb 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pharmacol. 2017 Feb 5 ;796:32-38. Epub 2016 Dec 15. PMID: 27988285
Article Published Date : Feb 04, 2017
Study Type : Animal Study
Additional Links
Substances : Cardamonin
Diseases : Allodynia, Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Centella asiatica (L.) Urban leaves demonstrated promising anti-nociceptive effects in animal models of migraine.Mar 31, 2015

Pubmed Data : Chin J Nat Med. 2015 Apr ;13(4):274-82. PMID: 25908624
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Headache: Migraine, Hyperalgesia
Pharmacological Actions : Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Chronic administration of resveratrol attenuates inflammation-induced mechanical hyperalgesia.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pain. 2016 Feb ;12. Epub 2016 Apr 11. PMID: 27068286
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Hyperalgesia
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Chronic monosodium glutamate administration induced hyperalgesia in mice.Dec 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Dec 21 ;10(1). Epub 2017 Dec 21. PMID: 29267217
Article Published Date : Dec 20, 2017
Study Type : Animal Study
Additional Links
Diseases : Hyperalgesia
Problem Substances : Monosodium Glutamate (MSG)
[+]

Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy.Apr 24, 2023

Pubmed Data : Chem Biol Interact. 2023 Apr 25 ;375:110402. Epub 2023 Feb 16. PMID: 36804429
Article Published Date : Apr 24, 2023
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Diabetic Neuropathy, Hyperalgesia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neurogenesis
[+]

Co-administration Bergamot polyphenolic fractions can be an important therapeutic approach to restore opioids analgesic efficacy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0156039. Epub 2016 May 26. PMID: 27227548
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bergamot
Diseases : Hyperalgesia, Morphine Tolerance/Dependence
Additional Keywords : Plant Extracts
[+]

Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia.Aug 31, 2018

Pubmed Data : Altern Ther Health Med. 2018 Sep ;24(5):33-43. PMID: 28987074
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Rhubarb
Diseases : Allodynia, Hyperalgesia
Pharmacological Actions : Antinoceceptive , Antioxidants, Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy, Phytotherapy, Plant Extracts
[+]

Crocin could attenuate hyperalgesia induced by sleep deprivation.Apr 30, 2020

Pubmed Data : Basic Clin Neurosci. 2020 May-Jun;11(3):261-267. Epub 2020 May 1. PMID: 32963719
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hyperalgesia, Insomnia, Sleep Disorders
Pharmacological Actions : Analgesics
[+]

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.Nov 05, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Haematologica. 2015 Nov 6. Epub 2015 Nov 6. PMID: 26546503
Article Published Date : Nov 05, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Coenzyme Q10, Curcumin
Diseases : Brain: Microglial Activation, Hyperalgesia, Sickle Cell Anemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.May 01, 2006

Pubmed Data : Eur J Pharmacol. 2006 May 1;536(3):256-61. Epub 2006 Mar 13. PMID: 16584726
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Neuropathies, Hyperalgesia
Pharmacological Actions : Analgesics, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin has antihyperalgesic properties. Feb 01, 2010

Pubmed Data : J Dent Res. 2010 Feb;89(2):170-4. Epub 2009 Dec 29. PMID: 20040737
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Hyperalgesia
Pharmacological Actions : Analgesics
[+]

Curcumin was found to have anti-hyperalgesic activity by decreasing oxidative stress and down regulation of inflammatory cytokines. Feb 28, 2015

Pubmed Data : Neurochem Res. 2015 Mar ;40(3):463-72. Epub 2014 Dec 6. PMID: 25479948
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Hyperalgesia, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Aug ;16(2):1559-1564. Epub 2017 Jun 8. PMID: 29067449
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Hyperalgesia, Oxidative Stress
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chem Biol Interact. 2017 Aug 1 ;273:180-189. Epub 2017 Jun 15. PMID: 28625489
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Hyperalgesia
Pharmacological Actions : Antinoceceptive
[+]

Effect of ultra-Micronized-palmitoylethanolamide and acetyl-l-carnitine on experimental model of inflammatory pain.Feb 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Feb 17 ;22(4). Epub 2021 Feb 17. PMID: 33671213
Article Published Date : Feb 16, 2021
Study Type : Animal Study
Additional Links
Substances : Carnitine, Palmitoylethanolamide
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Electroacupuncture induces antihyperalgesic effect through endothelin-B receptor in the chronic phase of a mouse model of complex regional pain syndrome type I.Jan 12, 2018

Pubmed Data : Pflugers Arch. 2018 12 ;470(12):1815-1827. Epub 2018 Aug 10. PMID: 30094478
Article Published Date : Jan 12, 2018
Study Type : Animal Study
Additional Links
Substances : Piperidines
Diseases : Complex Regional Pain Syndrome: Type I, Hyperalgesia
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics
[+]

Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain.Jun 12, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurosci Lett. 2014 Jun 13 ;571:66-71. Epub 2014 May 2. PMID: 24792391
Article Published Date : Jun 12, 2014
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e39647. Epub 2012 Jun 25. PMID: 22761855
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Diabetic Neuropathy, Hyperalgesia
Pharmacological Actions : Analgesics
[+]

Genistein reverses the effect of 17β-estradiol on exacerbating experimental occlusal interference-induced chronic masseter hyperalgesia.Jun 01, 2021

Pubmed Data : J Oral Rehabil. 2021 Jun 2. Epub 2021 Jun 2. PMID: 34075611
Article Published Date : Jun 01, 2021
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Hyperalgesia
Pharmacological Actions : Analgesics
[+]

H. procumbens cooperates synergistically with morphine in resolving hyperalgesia and allodynia.May 31, 2016

Pubmed Data : Nat Prod Res. 2016 Jun ;30(11):1248-55. Epub 2015 Jul 20. PMID: 26189616
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Devils Claw
Diseases : Allodynia, Hyperalgesia, Neuropathic Pain
Additional Keywords : Natural Substance/Drug Synergy
[+]

H. procumbens extracts have potential analgesic effects in the case of acute postoperative pain and chronic neuropathic pain in rats.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(1):1060-8. Epub 2014 Jan 16. PMID: 24441655
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Devils Claw
Diseases : Hyperalgesia, Neuropathic Pain, Postoperative Recovery
Pharmacological Actions : Analgesics
Additional Keywords : Plant Extracts
[+]

High-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Sep 1 ;12(1):14840. Epub 2022 Sep 1. PMID: 36050326
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Diseases : Allodynia, High Fat Diet, Hyperalgesia, Obesity
Additional Keywords : Risk Factors
[+]

Honokiol has a significant anti-nociceptive activity through inhibition of anti-inflammatory mediators.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:140. Epub 2018 Mar 20. PMID: 29615898
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Allodynia, Hyperalgesia
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants, Heme oxygenase-1 inducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Icariin ameliorates lower back pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:4670604. Epub 2020 Aug 5. PMID: 32802846
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Hyperalgesia, Low Back Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Loganin prevents chronic constriction injury-provoked neuropathic pain.Jan 31, 2020

Pubmed Data : Phytomedicine. 2020 Feb ;67:153166. Epub 2019 Dec 30. PMID: 31955133
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Dogwood
Diseases : Hyperalgesia, Nerve Compression Syndromes, Neuropathic Pain
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mangiferin has anti-inflammatory and analgesic properties when locally administrated.Jul 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Jul 5 ;830:87-94. Epub 2018 Apr 30. PMID: 29715452
Article Published Date : Jul 04, 2018
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mechanical hypersensitivity was inhibited by the antioxidative drug α-lipoic acid.Dec 31, 2021

Pubmed Data : Arch Oral Biol. 2022 Jan ;133:105317. Epub 2021 Nov 16. PMID: 34823152
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Hyperalgesia
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Mechanism of electroacupuncture analgesia on nicotine withdrawal-induced hyperalgesia.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:7975803. Epub 2022 Aug 29. PMID: 36072415
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Hyperalgesia, Smoking Cessation: Nicotine Addiction
Pharmacological Actions : Analgesics
[+]

Melatonin is a potential means for countering hyperalgesia induced by neonatal morphine exposure in young and adult rats.Aug 17, 2016

Pubmed Data : Neurosci Lett. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27546822
Article Published Date : Aug 17, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Hyperalgesia
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Morphine
[+]

Naringin has a protective effect against Intracerebral hemorrhage-induced neurocognitive deficits.Dec 31, 2016

Pubmed Data : Pharmacology. 2017 ;100(3-4):172-187. Epub 2017 Jul 1. PMID: 28668949
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Cerebral Hemorrhage, Hyperalgesia, Lipid Peroxidation
Pharmacological Actions : Neuroprotective Agents, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Olive leaf attenuates early diabetic neuropathic pain through prevention of high glucose-induced cell damage. Apr 22, 2011

Pubmed Data : J Ethnopharmacol. 2011 Apr 22. Epub 2011 Apr 22. PMID: 21540099
Article Published Date : Apr 22, 2011
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Hyperalgesia, Hyperglycemia, Neuropathic Pain
Pharmacological Actions : Analgesics, Antioxidants, Bax/Bcl2 Ratio: Decrease, Caspase-3 Inhibition
[+]

Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.Feb 29, 2004

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar ;369(3):294-9. Epub 2004 Feb 12. PMID: 14963641
Article Published Date : Feb 29, 2004
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Oridonin alleviates visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome.May 31, 2016

Pubmed Data : J Med Food. 2016 Jun ;19(6):586-92. Epub 2016 Apr 25. PMID: 27111743
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Oridonin
Diseases : Hyperalgesia, Irritable Bowel Syndrome
Pharmacological Actions : Analgesics
[+]

Paeoniflorin attenuates postoperative pain by suppressing matrix metalloproteinase-9/2 in mice.Dec 31, 2017

Pubmed Data : Eur J Pain. 2018 02 ;22(2):272-281. Epub 2017 Oct 29. PMID: 29081070
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Allodynia, Hyperalgesia
Pharmacological Actions : Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Palmitoylethanolamide could represent a novel approach for monitoring pain during trigeminal nerve sensitization.Sep 30, 2018

Pubmed Data : Inflamm Res. 2018 Oct ;67(10):891-901. Epub 2018 Aug 18. PMID: 30121836
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Hyperalgesia, Temporomandibular Joint Disorders
Pharmacological Actions : Analgesics
[+]

Palmitoylethanolamide possesses potential to treat peripheral neuropathy in cancer patients undergoing chemotherapy.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2016 Nov ;359(2):310-318. Epub 2016 Sep 8. PMID: 27608657
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy, Hyperalgesia
Pharmacological Actions : Chemoprotective Agents
[+]

PLGA-curcumin reversed opioid-induced hyperalgesia in mice at relatively low doses.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(1):e0146393. Epub 2016 Jan 8. PMID: 26744842
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Hyperalgesia
[+]

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain.Sep 01, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Sep 2 ;12(1):14980. Epub 2022 Sep 2. PMID: 36056079
Article Published Date : Sep 01, 2022
Study Type : Animal Study
Additional Links
Substances : Coffee, Grape
Diseases : Hyperalgesia, Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Analgesics
[+]

Possible role of antioxidative capacity of (-)-epigallocatechin-3-gallate treatment in morphological and neurobehavioral recovery after sciatic nerve crush injury.Nov 01, 2017

Pubmed Data : J Neurosurg Spine. 2017 Nov ;27(5):593-613. Epub 2017 Aug 4. PMID: 28777065
Article Published Date : Nov 01, 2017
Study Type : Animal Study
Additional Links
Substances : Catechin
Diseases : Hyperalgesia, Oxidative Stress, Sciatic Nerve Crush Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Postinjury treatment with magnesium sulfate attenuates neuropathic pains following spinal cord injury in male rats.Mar 31, 2015

Pubmed Data : Behav Pharmacol. 2015 Apr ;26(3):315-20. PMID: 25369748
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Magnesium Sulfate
Diseases : Hyperalgesia, Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Analgesics
[+]

Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel.Feb 14, 2017

Pubmed Data : Phytomedicine. 2017 Feb 15 ;25:1-7. Epub 2016 Dec 19. PMID: 28190463
Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Hyperalgesia
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2018 Jul ;13(7):1263-1268. PMID: 30028336
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Allodynia, Hyperalgesia, Peripheral Nerve Diseases
Pharmacological Actions : Analgesics
[+]

R. rosea ethanol extract may have potential as a treatment for diabetic hyperalgesia. Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Dev Res. 2016 Feb ;77(1):29-36. Epub 2016 Jan 13. PMID: 26763184
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Rhodiola (Tibetan Ginseng)
Diseases : Hyperalgesia
Pharmacological Actions : Antinoceceptive
Additional Keywords : Dose Response
[+]

Red-light (670 nm) therapy reduces mechanical sensitivity and neuronal cell death, and alters glial responses after spinal cord injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurotrauma. 2020 11 1 ;37(21):2244-2260. Epub 2020 Aug 10. PMID: 32552352
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Hyperalgesia, Spinal Cord Injuries
Therapeutic Actions : Light Therapy: Red Colored
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Repeated electroacupuncturecan relieve neuropathic pain and mirror-image pain in chronic neuropathic pain.Feb 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Feb 21 ;18(1):74. Epub 2018 Feb 21. PMID: 29466978
Article Published Date : Feb 20, 2018
Study Type : Animal Study
Additional Links
Diseases : Hyperalgesia, Neuropathic Pain
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics
[+]

Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain.Jan 31, 2018

Pubmed Data : Phytomedicine. 2018 Feb 1 ;40:59-67. Epub 2018 Jan 9. PMID: 29496176
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Rosemary
Diseases : Allodynia, Hyperalgesia
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sinomenine alleviates mechanical hypersensitivity in mice with experimentally induced rheumatoid arthritis.Mar 31, 2015

Pubmed Data : Scand J Pain. 2015 Apr 1 ;7(1):9-14. Epub 2015 Apr 1. PMID: 29911599
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Hyperalgesia, Rheumatoid Arthritis
Pharmacological Actions : Antinoceceptive
[+]

Synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.Jul 01, 2007

Pubmed Data : Neuropharmacology. 2007 Jul;53(1):169-77. Epub 2007 May 13. PMID: 17572451
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Cannabis
Diseases : Allodynia, Hyperalgesia, Trigeminal Neuralgia
Pharmacological Actions : Analgesics
[+]

T. gondii infection could promote neuroinflammation through cytokine networks and induced hyperalgesia in mice.Jan 31, 2016

Pubmed Data : Inflammation. 2016 Feb ;39(1):405-12. PMID: 26490968
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Hyperalgesia, Toxoplasma gondii Infection
[+]

Tanshinone IIA attenuates neuropathic pain via inhibiting glial activation and immune response.Dec 31, 2014

Pubmed Data : Pharmacol Biochem Behav. 2015 Jan ;128:1-7. Epub 2014 Nov 6. PMID: 25449357
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Hyperalgesia, Neuropathic Pain, Oxidative Stress
Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The analgesic effects of the Terminalia chebula extract are mediated by the suppression of brain NGF, NF-κB, and by its antioxidant activity.Oct 31, 2022

Pubmed Data : Mol Biol Rep. 2022 Nov ;49(11):10457-10467. Epub 2022 Sep 15. PMID: 36107372
Article Published Date : Oct 31, 2022
Study Type : Animal Study
Additional Links
Substances : Terminalia chebula
Diseases : Hyperalgesia, Neuropathic Pain, Oxidative Stress
Pharmacological Actions : Analgesics, Neuritogenic, NF-kappaB Inhibitor
[+]

The antinociceptive effect of H. procumbens requires the integrity of the HO-1/CO pathway.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(9):16758-69. Epub 2015 Sep 15. PMID: 26389871
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Devils Claw
Diseases : Allodynia, Hyperalgesia
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

The effect of verbascoside in neuropathic pain induced by chronic constriction injury in rats.Dec 31, 2015

Pubmed Data : Phytother Res. 2016 Jan ;30(1):128-35. Epub 2015 Nov 5. PMID: 26537351
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Hyperalgesia, Neuropathic Pain, Oxidative Stress
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.Feb 04, 2007

Pubmed Data : Eur J Pharmacol. 2007 Feb 5 ;556(1-3):75-83. Epub 2006 Nov 10. PMID: 17157290
Article Published Date : Feb 04, 2007
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Hyperalgesia, Inflammation, Neuropathic Pain
Pharmacological Actions : NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These data showed the anti-nociceptive and anti-inflammatory effects of essential oils from Chamaecyparis obtusa.Nov 30, 2015

Pubmed Data : Int Immunopharmacol. 2015 Dec ;29(2):320-5. Epub 2015 Nov 14. PMID: 26590113
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Hyperalgesia, Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive
Additional Keywords : Essential Oils
[+]

These data strongly support grape seed extract as an effective therapeutic approach in multiple sclerosis treatment.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2022 ;13:960355. Epub 2022 Aug 17. PMID: 36059517
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Hyperalgesia, Inflammation, Multiple Sclerosis
Pharmacological Actions : Antioxidants
[+]

These results demonstrate that TRPV1 receptor could be a molecular target of the CBD antihyperalgesic action.Aug 31, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2004 Sep ;143(2):247-50. Epub 2004 Aug 16. PMID: 15313881
Article Published Date : Aug 31, 2004
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

These results provide evidence that diosmin produces significant anti-hyperalgesic effects.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:310-320. Epub 2017 Nov 6. PMID: 29091880
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that electroacupuncture suppresses inflammation-induced hyperalgesia.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7531060. Epub 2017 Nov 22. PMID: 29358970
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Hyperalgesia
Therapeutic Actions : Electroacupuncture
[+]

Thiamine suppresses thermal hyperalgesia in rats. Feb 01, 2009

Pubmed Data : Anesthesiology. 2009 Feb;110(2):387-400. PMID: 19194165
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Thiamine (B-1)
Diseases : Hyperalgesia
[+]

Thiamine, pyridoxine, and cyanocobalamin inhibit thermal hyperalgesia in an animal model of neuropathic pain. Mar 01, 2005

Pubmed Data : Pain. 2005 Mar;114(1-2):266-77. Epub 2005 Jan 26. PMID: 15733653
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Thiamine (B-1) , Vitamin B-12, Vitamin B-6
Diseases : Hyperalgesia, Neuropathic Pain
[+]

This study elucidates the mechanism by which crocin alleviates neuropathic pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2020 ;2020:4297483. Epub 2020 Jan 11. PMID: 32399022
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hyperalgesia, Neuropathic Pain, Rheumatoid Arthritis
Pharmacological Actions : Analgesics, Wnt/β-catenin signaling pathway modulation
[+]

Ursolic acid may be a potential therapeutic option for the prevention of increased inflammatory pain in obese patients.May 31, 2016

Pubmed Data : Mol Med Rep. 2016 Jun ;13(6):5309-16. Epub 2016 Apr 22. PMID: 27108888
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : High Fat Diet, Hyperalgesia, Obesity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Vitexin may be useful for the control of postoperative pain.Jan 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Jan 14 ;6:19266. Epub 2016 Jan 14. PMID: 26763934
Article Published Date : Jan 13, 2016
Study Type : Animal Study
Additional Links
Substances : Vitexins
Diseases : Hyperalgesia, Postoperative Recovery
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

β-caryophyllene attenuates the non-inflammatory chronic muscle pain in mice and inhibits the Fos expression in the lumbar spinal cord.Mar 14, 2016

Pubmed Data : Life Sci. 2016 Mar 15 ;149:34-41. Epub 2016 Feb 13. PMID: 26883973
Article Published Date : Mar 14, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Cannabinoids
Diseases : Hyperalgesia, Inflammation, Muscle Soreness
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Cannabidiol for pain treatment: Focus on pharmacology and mechanism of action.Nov 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Nov 23 ;21(22). Epub 2020 Nov 23. PMID: 33238607
Article Published Date : Nov 22, 2020
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Allodynia, Chronic Pain, Hyperalgesia, Inflammation, Neuropathic Pain, Osteoarthritis
Pharmacological Actions : Analgesics
[+]

Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.Dec 31, 2020

Pubmed Data : Metab Brain Dis. 2021 02 ;36(2):273-283. Epub 2020 Nov 12. PMID: 33180213
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain.Oct 14, 2021

Pubmed Data : Eur J Pharmacol. 2021 Oct 15 ;909:174412. Epub 2021 Aug 8. PMID: 34375671
Article Published Date : Oct 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Hyperalgesia, Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

Tanshinone IIA attenuates chronic pancreatitis-induced pain.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Physician. 2015 Jul-Aug;18(4):E615-28. PMID: 26218952
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Hyperalgesia, Pancreatitis
Pharmacological Actions : Antinoceceptive
[+]

There are neurobiological mechanisms that may explain the hyperanalgesic consequences of the nocebo effect.Jun 29, 2007

Pubmed Data : Neuroscience. 2007 Jun 29;147(2):260-71. Epub 2007 Mar 26. PMID: 17379417
Article Published Date : Jun 29, 2007
Study Type : Commentary
Additional Links
Diseases : Hyperalgesia
Anti Therapeutic Actions : Nocebo Effect

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