Hypertension: Pulmonary

Name	AC	CK
Arginine	5	10
Iron	1	10
Astragaloside	4	8
Resveratrol	4	8
DHEA (Dehydroepiandrosterone)	3	6
Ginsenosides	3	6
Puerarin	3	6
DHA (Docosahexaenoic Acid)	1	5
Polyphenols	1	5
Vitamin C	2	5
Antioxidant formulas	2	4
Apple Polyphenols	2	4
Genistein	2	4
Grape Seed Extract	2	4
Melatonin	2	4
Red Sage	2	4
Chrysin	2	3
2-Methoxyestradiol	1	2
Allicin	1	2
Apigenin	1	2
Ashwagandha	1	2
Astragalus	1	2
Bacopa	1	2
Berberine	1	2
Blueberry	1	2
Caffeic acid phenethyl ester	1	2
Cannabidiol	1	2
Capsaicin	1	2
Citrulline	1	2
Curcumin	1	2
Cyanidin 3-glucoside	1	2
D-Ribose	1	2
EPA (Eicosapentaenoic Acid)	1	2
Folic Acid	1	2
Formononetin	1	2
Garlic	1	2
Ginkgo biloba	1	2
Green Tea	1	2
Holy Basil	1	2
Honokiol	1	2
Isoflavones	1	2
Isoliquiritigenin	1	2
Isoquercitrin	1	2
Ligustrazine	1	2
Magnolol	1	2
Milk Thistle	1	2
NAC (N-acetyl-L-cysteine)	1	2
Paeoniflorin	1	2
Paeonol	1	2
Protandim	1	2
Punicalagin	1	2
Sulforaphane	1	2
Tanshinone IIA	1	2
Turmeric	1	2
Xanthohumol	1	2
Baicalein	1	1
Cordyceps sinensis	1	1
Flavonoids	1	1
Fucoidan	1	1

Name	AC	CK
Antidepressants	1	10
Beta Blockers	1	10
Ibuprofen	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	10

Name	AC	CK	Focus
Electroacupuncture	1	2

[+]

Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Rev Fac Cien Med Univ Nac Cordoba. 2020 12 1 ;77(4):249-253. Epub 2020 Dec 1. PMID: 33351387

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Citrulline

Diseases : Heart Disease: Congenital, Hypertension: Pulmonary

Pharmacological Actions : Cardioprotective

[+]

In patients with moderate to severe portopulmonary hypertension, beta-blockers are associated with significant worsening in exercise capacity and pulmonary hemodynamics.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Gastroenterology. 2006 Jan;130(1):120-6. PMID: 16401475

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Hypertension: Portal, Pulmonary Hypertension

Problem Substances : Beta Blockers

[+]

Iron supplementation has a beneficial effect on hypoxic pulmonary hypertension.Oct 07, 2009

Click here to read the entire abstract

Pubmed Data : JAMA. 2009 Oct 7;302(13):1444-50. PMID: 19809026

Article Published Date : Oct 07, 2009

Study Type : Human Study

Additional Links

Substances : Iron

Diseases : Hypertension, Hypertension: Pulmonary

[+]

Use of SSRIs in the second half of pregnancy was associated with the risk of persistent pulmonary hypertension.Nov 21, 2016

Click here to read the entire abstract

Pubmed Data : Br J Clin Pharmacol. 2016 Nov 22. Epub 2016 Aug 22. PMID: 27874994

Article Published Date : Nov 21, 2016

Study Type : Human Study

Additional Links

Diseases : Fetal Origin of Adult Disease, Prenatal Chemical Exposures, Pulmonary Hypertension

Additional Keywords : Increased Risk

Problem Substances : Antidepressants

[+]

Polyphenol antioxidant treatment may provide an adjunctive action to alleviate pulmonary vascular remodeling.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Biol Sci. 2017 ;13(8):1067-1081. Epub 2017 Sep 3. PMID: 28924387

Article Published Date : Dec 31, 2016

Study Type : Human In Vitro

Additional Links

Substances : Polyphenols

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Nrf2 activation

[+]

These findings indicate that DHA activates PASMC KCa channels leading to vasorelaxation in pulmonary hypertension.Aug 17, 2016

Click here to read the entire abstract

Pubmed Data : Eur Respir J. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27540020

Article Published Date : Aug 17, 2016

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Vasodilator Agents

[+]

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Med Sci. 2022 ;19(4):681-694. Epub 2022 Mar 28. PMID: 35582418

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Paeoniflorin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Vitamin C deficiency-induced pulmonary arterial hypertension.Jan 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chest. 2020 Feb ;157(2):e21-e23. PMID: 32033656

Article Published Date : Jan 31, 2020

Study Type : Human: Case Report

Additional Links

Substances : Vitamin C

Diseases : Pulmonary Hypertension, Vitamin C Deficiency

Pharmacological Actions : Antihypertensive Agents

[+]

Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function Nov 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2020 Dec ;144(4):237-244. Epub 2020 Sep 10. PMID: 33070843

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Echinacea

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Vasodilator Agents

Additional Keywords : Phytotherapy

[+]

2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension.Sep 23, 2018

Click here to read the entire abstract

Pubmed Data : J Cell Physiol. 2018 Sep 24. Epub 2018 Sep 24. PMID: 30246291

Article Published Date : Sep 23, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : 2-Methoxyestradiol

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Anti-Angiogenic, MicroRNA modulator

[+]

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

Click here to read the entire abstract

Pubmed Data : Circulation. 2009 Nov 17;120(20):1951-60. Epub 2009 Nov 2. PMID: 19884466

Article Published Date : Nov 17, 2009

Study Type : Animal Study

Additional Links

Substances : Ashwagandha, Bacopa, Green Tea, Milk Thistle, Protandim, Turmeric

Diseases : Heart Failure, Hypertension, Hypertension: Pulmonary

Pharmacological Actions : Anti-Fibrotic, Vascular Endothelial Growth Factor A Inhibitor

[+]

Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.Nov 01, 2006

Click here to read the entire abstract

Pubmed Data : Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2431-8. Epub 2006 May 26. PMID: 16731642

Article Published Date : Nov 01, 2006

Study Type : Animal Study

Additional Links

Substances : Allicin, Garlic

Diseases : Endothelial Dysfunction, Hypertension: Pulmonary, Right Ventricular Hypertrophy

Additional Keywords : Plant Extracts

[+]

Allicin may be an alternative in treating pulmonary arterial hypertension.Aug 18, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2023 Aug 19 ;24(16). Epub 2023 Aug 19. PMID: 37629140

Article Published Date : Aug 18, 2023

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

Andrographolide attenuates established pulmonary hypertension.Jan 29, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomolecules. 2021 11 30 ;11(12). Epub 2021 Nov 30. PMID: 34944445

Article Published Date : Jan 29, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Andrographolide

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation

[+]

Anti-inflammatory effect of allicin associated with fibrosis in pulmonary arterial hypertension.Aug 09, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2021 Aug 10 ;22(16). Epub 2021 Aug 10. PMID: 34445305

Article Published Date : Aug 09, 2021

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure. Mar 01, 2010

Click here to read the entire abstract

Pubmed Data : Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1038-47. Epub 2010 Jan 8. PMID: 20061549

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Substances : Antioxidant formulas

Diseases : Hypertension: Pulmonary, Right Ventricular Hypertrophy

[+]

Antioxidants attenuate chronic hypoxic pulmonary hypertension.Nov 01, 1998

Click here to read the entire abstract

Pubmed Data : J Cardiovasc Pharmacol. 1998 Nov;32(5):714-20. PMID: 9821844

Article Published Date : Nov 01, 1998

Study Type : Animal Study

Additional Links

Substances : Antioxidant formulas

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antioxidants

[+]

Apigenin attenuates pulmonary hypertension.Jan 09, 2020

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2020 Jan 10 ;317:108942. Epub 2020 Jan 10. PMID: 31930969

Article Published Date : Jan 09, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

Apple polyphenol relieves hypoxia-induced pulmonary arterial hypertension.Oct 31, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:937-944. Epub 2018 Aug 23. PMID: 30257406

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Apple Polyphenols

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents

[+]

Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2021 Jan ;23(1). Epub 2020 Nov 25. PMID: 33236156

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Hypertension

Pharmacological Actions : Cytoprotective

[+]

Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.Dec 07, 2020

Click here to read the entire abstract

Pubmed Data : J Cell Mol Med. 2020 Dec 8. Epub 2020 Dec 8. PMID: 33295020

Article Published Date : Dec 07, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

[+]

Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension.Jan 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2021 Feb ;47(2):595-606. Epub 2020 Dec 8. PMID: 33416126

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Astragaloside IV improves pulmonary arterial hypertension.Feb 09, 2023

Click here to read the entire abstract

Pubmed Data : J Cell Mol Med. 2023 Feb 10. Epub 2023 Feb 10. PMID: 36762748

Article Published Date : Feb 09, 2023

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension.Oct 11, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pulm Med. 2023 Oct 12 ;23(1):386. Epub 2023 Oct 12. PMID: 37828459

Article Published Date : Oct 11, 2023

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Fibrotic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

Astragalus appears to have an inhibitory effect on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Nutr J. 2008;7:11. Epub 2008 Apr 21. PMID: 11189248

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Hypertrophy: Right Ventricular, Pulmonary Hypertension

[+]

Berberine attenuates pulmonary arterial hypertension.Aug 04, 2018

Click here to read the entire abstract

Pubmed Data : J Cell Physiol. 2018 Aug 5. Epub 2018 Aug 5. PMID: 30078229

Article Published Date : Aug 04, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension.Sep 12, 2019

Click here to read the entire abstract

Pubmed Data : Nutrition. 2019 Sep 13 ;70:110579. Epub 2019 Sep 13. PMID: 31743815

Article Published Date : Sep 12, 2019

Study Type : Animal Study

Additional Links

Substances : Blueberry

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Caffeic acid phenethyl ester rescues pulmonary arterial hypertension.Mar 21, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2019 Mar 22 ;20(6). Epub 2019 Mar 22. PMID: 30909527

Article Published Date : Mar 21, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Caffeic acid phenethyl ester

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway.Jul 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biochim Biophys Acta Mol Basis Dis. 2023 Aug ;1869(6):166753. Epub 2023 May 13. PMID: 37187449

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Heart Failure, Hypertension: Pulmonary, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

[+]

Cannabidiol ameliorates monocrotaline-induced pulmonary hypertension in rats. Sep 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Sep 25 ;21(19). Epub 2020 Sep 25. PMID: 32992900

Article Published Date : Sep 24, 2020

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.Feb 01, 1995

Click here to read the entire abstract

Pubmed Data : Respir Physiol. 1995 Feb;99(2):283-9. PMID: 7539934

Article Published Date : Feb 01, 1995

Study Type : Animal Study

Additional Links

Substances : Capsaicin

Diseases : Hypertension, Hypertension: Pulmonary, Hypoxia

[+]

Celastrol attenuates the remodeling of pulmonary vascular and right ventricular in monocrotaline-induced pulmonary arterial hypertension.Jan 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cardiovasc Diagn Ther. 2022 Feb ;12(1):88-102. PMID: 35282664

Article Published Date : Jan 31, 2022

Study Type : Animal Study

Additional Links

Substances : Celastrol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Vasoprotective

[+]

Chrysin alleviates monocrotaline-induced pulmonary hypertension.May 31, 2020

Click here to read the entire abstract

Pubmed Data : J Cardiovasc Pharmacol. 2020 Jun ;75(6):596-602. PMID: 32168153

Article Published Date : May 31, 2020

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Crocin may play a protective role in MCT-induced PAH rats by alleviating inflammatory response.Dec 01, 2021

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2021 Dec 2:1-19. Epub 2021 Dec 2. PMID: 34931588

Article Published Date : Dec 01, 2021

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Curcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.Aug 01, 2006

Click here to read the entire abstract

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Aug;22(3):257-61. PMID: 21158062

Article Published Date : Aug 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Hypercapnia, Hypoxia, Pulmonary Hypertension

Pharmacological Actions : Cardioprotective

[+]

Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline.Apr 30, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2021 May ;23(5). Epub 2021 Mar 24. PMID: 33760143

Article Published Date : Apr 30, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cyanidin 3-glucoside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Transforming growth factor beta (TGF-β) inhibitor

[+]

Danshensu might be suitable for clinical treatment of early-stage hypoxic pulmonary hypertension.Apr 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Med Res. 2020 May ;48(5):300060520914218. PMID: 32419546

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Hypertension, Hypertension: Pulmonary, Prehypertension

Pharmacological Actions : Antihypertensive Agents

[+]

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension.Aug 05, 2003

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9488-93. Epub 2003 Jul 23. PMID: 12878719

Article Published Date : Aug 05, 2003

Study Type : Animal Study

Additional Links

Substances : DHEA (Dehydroepiandrosterone)

Diseases : Hypertension: Pulmonary, Hypoxia

[+]

Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats.Mar 01, 1997

Click here to read the entire abstract

Pubmed Data : Biol Pharm Bull. 1997 Mar;20(3):243-8. PMID: 12765434

Article Published Date : Mar 01, 1997

Study Type : Animal Study

Additional Links

Substances : DHEA (Dehydroepiandrosterone)

Diseases : Hypoxia, Pulmonary Hypertension

[+]

Dehydroepiandrosterone upregulates inhibits hypoxic pulmonary hypertension.Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : Cardiovasc Res. 2007 Jun 1;74(3):377-87. Epub 2007 Feb 12. PMID: 17346686

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : DHEA (Dehydroepiandrosterone)

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Vasodilator Agents

[+]

Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism.May 27, 2019

Click here to read the entire abstract

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 May 28 ;35(3):209-214. PMID: 31257800

Article Published Date : May 27, 2019

Study Type : Animal Study

Additional Links

Substances : Apple Polyphenols

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

[+]

Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension.Nov 30, 1995

Click here to read the entire abstract

Pubmed Data : Hua Xi Yi Ke Da Xue Xue Bao. 1995 Dec ;26(4):386-90. PMID: 8732057

Article Published Date : Nov 30, 1995

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Eicosapentaenoic acid may have a therapeutic role in attenuating pulmonary hypertension. Jun 25, 2010

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2010 Jun 25;636(1-3):108-13. Epub 2010 Mar 27. PMID: 20347779

Article Published Date : Jun 25, 2010

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Endothelial Dysfunction, Pulmonary Hypertension

Pharmacological Actions : Nitric Oxide Enhancer

[+]

Electroacupuncture protects against hypoxia-induced pulmonary hypertension.May 01, 2010

Click here to read the entire abstract

Pubmed Data : Exp Biol Med (Maywood). 2010 May;235(5):642-8. PMID: 20463305

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Hypoxia, Pulmonary Hypertension

Therapeutic Actions : Electroacupuncture

[+]

Folic acid and d-ribose partially prevent right ventricular hypertrophy in rats. Sep 01, 2007

Click here to read the entire abstract

Pubmed Data : Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1869-76. Epub 2007 Jun 29. PMID: 17604325

Article Published Date : Sep 01, 2007

Study Type : Animal Study

Additional Links

Substances : D-Ribose, Folic Acid

Diseases : Hypertension, Hypertension: Pulmonary, Right Ventricular Hypertrophy

[+]

Genistein attenuates low temperature induced pulmonary hypertension in broiler chicks by modulating endothelial function.Dec 15, 2010

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2010 Dec 15;649(1-3):242-8. Epub 2010 Sep 18. PMID: 20854807

Article Published Date : Dec 15, 2010

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Pulmonary Hypertension

Pharmacological Actions : Nitric Oxide Enhancer

[+]

Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension, right ventricular hypertrophy, and pulmonary vascular remodeling in rats.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Respiration. 2006;73(1):105-12. Epub 2005 Oct 1. PMID: 16432296

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Endothelial Dysfunction, Pulmonary Hypertension, Right Ventricular Hypertrophy

Pharmacological Actions : Enzyme Inhibitors

[+]

Gingko biloba reduces hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Dec 01, 1996

Click here to read the entire abstract

Pubmed Data : Hua Xi Yi Ke Da Xue Xue Bao. 1996 Dec;27(4):415-7. PMID: 9389016

Article Published Date : Dec 01, 1996

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Hypertension: Pulmonary, Right Ventricular Hypertrophy

[+]

Ginsenoside Rb1 is a promising candidate for pulmonary hypertension prevention.Nov 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2020 Dec ;58(1):1055-1063. PMID: 33096951

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension.Jul 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2023 Aug ;164:114920. Epub 2023 May 20. PMID: 37216706

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Hypertension: Pulmonary, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginsenosides have promising therapeutic potential for pulmonary hypertension.Jun 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ginseng Res. 2016 Jul ;40(3):285-91. Epub 2015 Oct 22. PMID: 27616905

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 May ;101:123-128. Epub 2018 Feb 23. PMID: 29482057

Article Published Date : Apr 30, 2018

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Heat Shock Protein Down-Regulation

Additional Keywords : Proanthocyanidins

[+]

Grape seed procyanidin suppresses inflammation caused by cigarette smoke.Sep 29, 2019

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2019 Sep 30. Epub 2019 Sep 30. PMID: 31791634

Article Published Date : Sep 29, 2019

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Procyanidins

[+]

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.Feb 29, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2020 Mar ;21(3):1192-1200. Epub 2020 Jan 3. PMID: 31922224

Article Published Date : Feb 29, 2020

Study Type : Animal Study

Additional Links

Substances : Formononetin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Isoliquiritigenin attenuates monocrotaline-induced pulmonary hypertension.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:4568198. Epub 2019 May 26. PMID: 31239860

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Isoliquiritigenin

Diseases : Pulmonary Hypertension

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative

[+]

Isoquercitrin protects against pulmonary hypertension Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : Clin Exp Pharmacol Physiol. 2017 Mar ;44(3):362-370. PMID: 27873355

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Substances : Isoquercitrin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Antiproliferative , Cyclin D1 Down-Regulation

[+]

Kaempferol ameliorates pulmonary vascular remodeling in chronic hypoxia-induced pulmonary hypertension.Apr 30, 2023

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2023 May 1 ;466:116478. Epub 2023 Mar 20. PMID: 36940862

Article Published Date : Apr 30, 2023

Study Type : Animal Study

Additional Links

Substances : Kaempferol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Apoptotic, Antihypertensive Agents

[+]

L-arginine ameliorates hypoxic pulmonary hypertension.Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1042-50. Epub 2009 Apr 3. PMID: 19346433

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Angiogenesis Inducing Agents, Vascular Endothelial Growth Factor A Inhibitor

[+]

L-arginine compares favorably with calcium channel blockers in the treatment of hypoxic pulmonary hypertension and right ventricular hypertrophy. Dec 01, 1994

Click here to read the entire abstract

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 1994 Dec;17(6):372-4, 385. PMID: 7712585

Article Published Date : Dec 01, 1994

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Pulmonary Hypertension, Right Ventricular Hypertrophy

Additional Keywords : Drugs: Calcium Channel Blockers, Natural Substances Versus Drugs

[+]

L-arginine has a protective effect against hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in rats. Mar 01, 1996

Click here to read the entire abstract

Pubmed Data : Hua Xi Yi Ke Da Xue Xue Bao. 1996 Mar;27(1):68-70. PMID: 9208624

Article Published Date : Mar 01, 1996

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Hypertension: Pulmonary, Right Ventricular Hypertrophy

[+]

l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats.Feb 26, 2008

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2008 Feb 26;581(1-2):148-56. Epub 2007 Nov 28. PMID: 18164288

Article Published Date : Feb 26, 2008

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Nitric Oxide Enhancer

[+]

L-argining may attenuate experimentally-induced pulmonary artery hypertension in rats. Mar 09, 2010

Click here to read the entire abstract

Pubmed Data : Am J Physiol Endocrinol Metab. 2010 Mar 9. Epub 2010 Mar 9. PMID: 20215577

Article Published Date : Mar 09, 2010

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Hypertension: Pulmonary, Hypertrophy: Right Ventricular, Right Ventricular Hypertrophy

[+]

L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets.Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L506-11. Epub 2009 Jul 17. PMID: 19617312

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Citrulline

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Nitric Oxide Enhancer

[+]

Luteolin ameliorates hypoxia-induced pulmonary hypertension.Aug 31, 2022

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2022 Sep ;104:154329. Epub 2022 Jul 8. PMID: 35843187

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antihypertensive Agents

[+]

Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2018 Dec 1 ;51:205-213. Epub 2018 Oct 4. PMID: 30466619

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Magnolol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension.Nov 26, 2019

Click here to read the entire abstract

Pubmed Data : Cardiovasc Res. 2019 Nov 27. Epub 2019 Nov 27. PMID: 31774487

Article Published Date : Nov 26, 2019

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents

[+]

N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia.May 27, 2005

Click here to read the entire abstract

Pubmed Data : Life Sci. 2005 May 27;77(2):175-82. Epub 2005 Feb 1. PMID: 15862602

Article Published Date : May 27, 2005

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antioxidants

[+]

Naringin ameliorates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:696135. Epub 2021 Jul 15. PMID: 34335261

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension.Jul 31, 2023

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2023 Aug 1 ;75(8):1100-1110. PMID: 37158759

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents

[+]

Pachymic acid ameliorates pulmonary hypertension.Jan 31, 2022

Click here to read the entire abstract

Pubmed Data : Curr Med Sci. 2022 Feb ;42(1):56-67. Epub 2021 Dec 7. PMID: 34881424

Article Published Date : Jan 31, 2022

Study Type : Animal Study

Additional Links

Substances : Poria cocos

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Nrf2 activation

[+]

Paeoniflorin ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2020 ;14:1191-1202. Epub 2020 Mar 19. PMID: 32256050

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Paeoniflorin

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antihypertensive Agents

[+]

Paeonol represents a potential novel therapeutic approach for the treatment of pulmonary hypertension.Sep 04, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2018 Sep 5 ;834:257-265. Epub 2018 Jul 25. PMID: 30053410

Article Published Date : Sep 04, 2018

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antihypertensive Agents

[+]

Panax notoginseng saponins improve monocrotaline-induced pulmonary arterial hypertension.Aug 24, 2023

Click here to read the entire abstract

Pubmed Data : Sheng Li Xue Bao. 2023 Aug 25 ;75(4):503-511. PMID: 37583037

Article Published Date : Aug 24, 2023

Study Type : Animal Study

Additional Links

Substances : Panax Notoginseng

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2021 ;16(4):e0249816. Epub 2021 Apr 8. PMID: 33831045

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Protective effects of astragaloside IV against hypoxic pulmonary hypertension.Sep 30, 2018

Click here to read the entire abstract

Pubmed Data : Medchemcomm. 2018 Oct 1 ;9(10):1715-1721. Epub 2018 Sep 4. PMID: 30429976

Article Published Date : Sep 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Puerarin has the therapeutic effect on the pulmonary hypertension and accompanying pulmonary fibrosis.May 31, 2018

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Jun ;43(12):2618-2623. PMID: 29950085

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Fibrosis, Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Anti-Fibrotic

[+]

Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy.Sep 27, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2019 Sep 28. Epub 2019 Sep 28. PMID: 31640920

Article Published Date : Sep 27, 2019

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antihypertensive Agents, Autophagy Inhibitors

[+]

Punicalagin prevents hypoxic pulmonary hypertension in rats. Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2016 ;44(4):785-801. Epub 2016 Aug 24. PMID: 27222062

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Punicalagin

Diseases : Endothelial Dysfunction, Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Antioxidants

[+]

Red sage (764-3) prevents right ventricular collagen deposition induced by hypoxia (low oxygen) and has a therapeutic effect on monocrotaline -induced pulmontary hypertension in rats. Feb 01, 1998

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Feb;18(2):97-100. PMID: 11367654

Article Published Date : Feb 01, 1998

Study Type : Animal Study

Additional Links

Substances : Red Sage

Diseases : Pulmonary Hypertension, Right Ventricular Hypertrophy

Pharmacological Actions : Calcium Channel Blockers

Additional Keywords : Plant Extracts

[+]

Red sage extract may have therapeutic activity in reducing hypoxia-induced pulmonary hypertension.May 01, 2003

Click here to read the entire abstract

Pubmed Data : Chin Med J (Engl). 2003 May;116(5):757-60. PMID: 12875696

Article Published Date : May 01, 2003

Study Type : Animal Study

Additional Links

Substances : Red Sage

Diseases : Hypertension: Pulmonary, Hypoxia

[+]

Regular consumption of xanthohumol through fortified beer modulates major remodelling pathways activated in experimental pulmonary arterial hypertension.Mar 08, 2019

Click here to read the entire abstract

Pubmed Data : Nutrients. 2019 Mar 9 ;11(3). Epub 2019 Mar 9. PMID: 30857304

Article Published Date : Mar 08, 2019

Study Type : Animal Study

Additional Links

Substances : Xanthohumol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Cytoprotective

[+]

Resveratrol attenuated pulmonary arterial remodeling, decreased pulmonary arterial pressure, and upregulated SIRT1 and p21 expression.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2015 ;2015:762349. Epub 2015 Jul 26. PMID: 26273643

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : P21 Activation, SIRT1 Activator

[+]

Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats.Feb 01, 2010

Click here to read the entire abstract

Pubmed Data : Clin Exp Pharmacol Physiol. 2010 Feb;37(2):150-5. Epub 2009 Jun 29. PMID: 19566840

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Hypertension: Pulmonary, Right Ventricular Hypertrophy

[+]

Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Hypertension. 2009 Sep;54(3):668-75. Epub 2009 Jul 13. PMID: 19597040

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Endothelial Dysfunction, Hypertension, Hypertension: Pulmonary, Oxidative Stress

Pharmacological Actions : Antiproliferative , Interleukin-6 Downregulation, Vasodilator Agents

Additional Keywords : Stilbenes

[+]

Resveratrol protects against pulmonary arterial hypertension in rats.May 10, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2017 May 11 ;42(1):55-67. Epub 2017 May 11. PMID: 28494457

Article Published Date : May 10, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Shikonin improved experimental pulmonary arterial hypertension hemodynamics and pulmonary vascular remodeling.Feb 28, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2023 Mar ;27(3). Epub 2023 Feb 3. PMID: 36734266

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Substances : Shikonin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension.Dec 31, 2022

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2023 Jan ;111:109182. Epub 2022 Oct 9. PMID: 36220525

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Hypertension: Pulmonary, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Isothiocyanates

[+]

Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension.Mar 31, 2020

Click here to read the entire abstract

Pubmed Data : Am J Physiol Heart Circ Physiol. 2020 Apr 1 ;318(4):H853-H866. Epub 2020 Feb 28. PMID: 32108526

Article Published Date : Mar 31, 2020

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Pulmonary Hypertension

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

Tanshinone IIA attenuates hypoxic pulmonary hypertension via modulating KV currents.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Respir Physiol Neurobiol. 2015 Jan 1 ;205:120-8. Epub 2014 Oct 7. PMID: 25305099

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hypertension: Pulmonary

[+]

Tetramethylpyrazine is a promising treatment of pulmonary hypertension.Jan 23, 2020

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2020 Jan 24. Epub 2020 Jan 24. PMID: 31976548

Article Published Date : Jan 23, 2020

Study Type : Animal Study

Additional Links

Substances : Ligustrazine

Diseases : Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

The isoflavone puerarin improves pulmonary vascular remodeling in rats with pulmonary hypertension by inhibiting the deposition of collagen.Mar 01, 2008

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 Mar;33(5):544-9. PMID: 18536380

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Puerarin

Diseases : Hypertension: Pulmonary, Oxidative Stress

[+]

The present study demonstrates that Ocimum sanctum has therapeutic ability against monocrotaline-induced pulmonary hypertension.Apr 16, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicines (Basel). 2018 Apr 17 ;5(2). Epub 2018 Apr 17. PMID: 29673152

Article Published Date : Apr 16, 2018

Study Type : Animal Study

Additional Links

Substances : Holy Basil

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

The results revealed that honokiol can alleviate autophagy and pulmonary arterial hypertension.Feb 28, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2019 Mar ;139(3):158-165. Epub 2019 Feb 1. PMID: 30770282

Article Published Date : Feb 28, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents, Autophagy Inhibitors

[+]

These findings strongly support the significant role of notoginsenoside R1 in the inhibition of hypoxia-hypercapnia-induced vasoconstriction.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2014 ;42(4):799-816. PMID: 25004876

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Hypercapnia, Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Vasodilator Agents

[+]

These results suggest that melatonin attenuates pulmonary hypertension.May 23, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 May 24 ;18(6). Epub 2017 May 24. PMID: 28538666

Article Published Date : May 23, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents

[+]

Treatment with tanshinone IIA can improve MCT-induced pulmonary hypertension.May 19, 2022

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2022 May 20 ;42(5):718-723. PMID: 35673916

Article Published Date : May 19, 2022

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Vasodilatory effects of betaine on isolated rat pulmonary artery rings.Sep 30, 2021

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2021 Oct 1 ;76(10):499-502. PMID: 34620278

Article Published Date : Sep 30, 2021

Study Type : Animal Study

Additional Links

Substances : Betaine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Vasodilator Agents

[+]

Vitamin C may have a therapeutic role in ameliorating pulmonary hypertension.Dec 01, 2002

Click here to read the entire abstract

Pubmed Data : Br Poult Sci. 2002 Dec;43(5 Suppl):705-12. PMID: 12555895

Article Published Date : Dec 01, 2002

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Hypertension: Pulmonary

[+]

Baicalin attenuated the abnormal proliferation of HPASMCs through suppression of the HIF-1α and AhR pathways.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2014 Oct ;66(10):1469-77. Epub 2014 May 18. PMID: 24835111

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Baicalein, Flavonoids

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Hypoxia-inducible factor-1 (HIF-1) inhibitor

Additional Keywords : Plant Extracts

[+]

Chrysin alleviates chronic hypoxia-induced pulmonary hypertension.Oct 31, 2019

Click here to read the entire abstract

Pubmed Data : J Cardiovasc Pharmacol. 2019 Nov ;74(5):426-435. PMID: 31725079

Article Published Date : Oct 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Hypoxia, Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

Cordyceps s may have therapeutic value in the treatment of pulmonary hypertension.Sep 01, 2010

Click here to read the entire abstract

Pubmed Data : Saudi Med J. 2010 Sep;31(9):974-9. PMID: 20844807

Article Published Date : Sep 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Hypoxia, Pulmonary Hypertension

[+]

Fucoidan is a potent natural adjuvant representing a promising therapeutic approach for pulmonary hypertension.Dec 16, 2018

Click here to read the entire abstract

Pubmed Data : Am J Respir Crit Care Med. 2018 Dec 17. Epub 2018 Dec 17. PMID: 30557519

Article Published Date : Dec 16, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Magnolol alleviates hypoxia-induced pulmonary vascular remodeling through inhibition of phenotypic transformation in pulmonary arterial smooth muscle cells.May 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2022 Jun ;150:113060. Epub 2022 May 6. PMID: 35658230

Article Published Date : May 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Magnolol

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antiproliferative

[+]

Piperlongumine attenuates vascular remodeling in hypoxic pulmonary hypertension by regulating autophagy.Dec 31, 2021

Click here to read the entire abstract

Pubmed Data : J Cardiol. 2022 Jan ;79(1):134-143. Epub 2021 Sep 10. PMID: 34518076

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Vasoprotective

[+]

Protective effect of baicalin against pulmonary arterial hypertension vascular remodeling through regulation of TNF-α signaling pathway.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacol Res Perspect. 2021 02 ;9(1):e00703. PMID: 33421306

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents

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View the Evidence: 106 Abstracts with Hypertension: Pulmonary Research

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A case of pulmonary hypertension following L-lysine ibuprofen therapy has been reported in a preterm infant with patent ductus arteriosus.Jun 20, 2006

Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery.Dec 31, 2019

In patients with moderate to severe portopulmonary hypertension, beta-blockers are associated with significant worsening in exercise capacity and pulmonary hemodynamics.Jan 01, 2006

Iron supplementation has a beneficial effect on hypoxic pulmonary hypertension.Oct 07, 2009

Use of SSRIs in the second half of pregnancy was associated with the risk of persistent pulmonary hypertension.Nov 21, 2016

Polyphenol antioxidant treatment may provide an adjunctive action to alleviate pulmonary vascular remodeling.Dec 31, 2016

These findings indicate that DHA activates PASMC KCa channels leading to vasorelaxation in pulmonary hypertension.Aug 17, 2016

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2021

Vitamin C deficiency-induced pulmonary arterial hypertension.Jan 31, 2020

Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function Nov 30, 2020

2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension.Sep 23, 2018

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.Nov 01, 2006

Allicin may be an alternative in treating pulmonary arterial hypertension.Aug 18, 2023

Andrographolide attenuates established pulmonary hypertension.Jan 29, 2021

Anti-inflammatory effect of allicin associated with fibrosis in pulmonary arterial hypertension.Aug 09, 2021

Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure. Mar 01, 2010

Antioxidants attenuate chronic hypoxic pulmonary hypertension.Nov 01, 1998

Apigenin attenuates pulmonary hypertension.Jan 09, 2020

Apple polyphenol relieves hypoxia-induced pulmonary arterial hypertension.Oct 31, 2018

Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway.Dec 31, 2020

Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.Dec 07, 2020

Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension.Jan 31, 2021

Astragaloside IV improves pulmonary arterial hypertension.Feb 09, 2023

Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension.Oct 11, 2023

Astragalus appears to have an inhibitory effect on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Jan 01, 2008

Berberine attenuates pulmonary arterial hypertension.Aug 04, 2018

Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension.Sep 12, 2019

Caffeic acid phenethyl ester rescues pulmonary arterial hypertension.Mar 21, 2019

Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway.Jul 31, 2023

Cannabidiol ameliorates monocrotaline-induced pulmonary hypertension in rats. Sep 24, 2020

Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.Feb 01, 1995

Celastrol attenuates the remodeling of pulmonary vascular and right ventricular in monocrotaline-induced pulmonary arterial hypertension.Jan 31, 2022

Chrysin alleviates monocrotaline-induced pulmonary hypertension.May 31, 2020

Crocin may play a protective role in MCT-induced PAH rats by alleviating inflammatory response.Dec 01, 2021

Curcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.Aug 01, 2006

Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline.Apr 30, 2021

Danshensu might be suitable for clinical treatment of early-stage hypoxic pulmonary hypertension.Apr 30, 2020

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension.Aug 05, 2003

Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats.Mar 01, 1997

Dehydroepiandrosterone upregulates inhibits hypoxic pulmonary hypertension.Jun 01, 2007

Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism.May 27, 2019

Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension.Nov 30, 1995

Eicosapentaenoic acid may have a therapeutic role in attenuating pulmonary hypertension. Jun 25, 2010

Electroacupuncture protects against hypoxia-induced pulmonary hypertension.May 01, 2010

Folic acid and d-ribose partially prevent right ventricular hypertrophy in rats. Sep 01, 2007

Genistein attenuates low temperature induced pulmonary hypertension in broiler chicks by modulating endothelial function.Dec 15, 2010

Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension, right ventricular hypertrophy, and pulmonary vascular remodeling in rats.Jan 01, 2006

Gingko biloba reduces hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Dec 01, 1996

Ginsenoside Rb1 is a promising candidate for pulmonary hypertension prevention.Nov 30, 2020

Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension.Jul 31, 2023

Ginsenosides have promising therapeutic potential for pulmonary hypertension.Jun 30, 2016

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Grape seed procyanidin suppresses inflammation caused by cigarette smoke.Sep 29, 2019

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.Feb 29, 2020

Isoliquiritigenin attenuates monocrotaline-induced pulmonary hypertension.Dec 31, 2018

Isoquercitrin protects against pulmonary hypertension Feb 28, 2017

Kaempferol ameliorates pulmonary vascular remodeling in chronic hypoxia-induced pulmonary hypertension.Apr 30, 2023

L-arginine ameliorates hypoxic pulmonary hypertension.Jun 01, 2009

L-arginine compares favorably with calcium channel blockers in the treatment of hypoxic pulmonary hypertension and right ventricular hypertrophy. Dec 01, 1994

L-arginine has a protective effect against hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in rats. Mar 01, 1996

l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats.Feb 26, 2008

L-argining may attenuate experimentally-induced pulmonary artery hypertension in rats. Mar 09, 2010

L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets.Sep 01, 2009

Luteolin ameliorates hypoxia-induced pulmonary hypertension.Aug 31, 2022

Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension.Nov 30, 2018

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension.Nov 26, 2019

N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia.May 27, 2005

Naringin ameliorates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2020

Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension.Jul 31, 2023

Pachymic acid ameliorates pulmonary hypertension.Jan 31, 2022

Paeoniflorin ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension.Dec 31, 2019

Hypertension: Pulmonary

View the Evidence:
106 Abstracts with Hypertension: Pulmonary Research