Hypertension: Pulmonary

Name	AC	CK
Astragaloside	6	12
Citrulline	2	12
Arginine	5	10
Ginsenosides	5	10
Iron	1	10
Resveratrol	4	8
Vitamin C	4	7
Allicin	3	6
Cannabidiol	3	6
DHEA (Dehydroepiandrosterone)	3	6
Puerarin	3	6
DHA (Docosahexaenoic Acid)	1	5
Paeoniflorin	2	5
Polyphenols	1	5
Antioxidant formulas	2	4
Apple Polyphenols	2	4
Crocin	2	4
Genistein	2	4
Ginkgo biloba	2	4
Grape Seed Extract	2	4
Melatonin	2	4
Red Sage	2	4
Sulforaphane	2	4
Tanshinone IIA	2	4
Chrysin	2	3
Magnolol	2	3
Wogonin	1	3
2-Methoxyestradiol	1	2
Andrographolide	1	2
Apigenin	1	2
Ashwagandha	1	2
Astragalus	1	2
Bacopa	1	2
Beet	1	2
Berberine	1	2
Betaine	1	2
Blueberry	1	2
Caffeic acid phenethyl ester	1	2
Capsaicin	1	2
Celastrol	1	2
Citrus naringin	1	2
Curcumin	1	2
Cyanidin 3-glucoside	1	2
D-Ribose	1	2
EPA (Eicosapentaenoic Acid)	1	2
Echinacea	1	2
Flavonoids	2	2
Folic Acid	1	2
Formononetin	1	2
Garlic	1	2
Green Tea	1	2
Holy Basil	1	2
Honokiol	1	2
Isoflavones	1	2
Isoliquiritigenin	1	2
Isoquercitrin	1	2
Kaempferol	1	2
Ligustrazine	1	2
Luteolin	1	2
Milk Thistle	1	2
NAC (N-acetyl-L-cysteine)	1	2
Nobiletin	1	2
Paeonol	1	2
Panax Notoginseng	1	2
Poria cocos	1	2
Protandim	1	2
Punicalagin	1	2
Salvia miltiorrhiza	1	2
Shikonin	1	2
Turmeric	1	2
Urolithin A	1	2
Xanthohumol	1	2
Baicalein	1	1
Cordyceps sinensis	1	1
Fucoidan	1	1
Piperlongumine	1	1
Vitamin E	1	1

Name	AC	CK
Antidepressants	1	10
Beta Blockers	1	10
Ibuprofen	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	10

Name	AC	CK	Focus
Electroacupuncture	1	2

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A case of pulmonary hypertension following L-lysine ibuprofen therapy has been reported in a preterm infant with patent ductus arteriosus.Jun 20, 2006

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Pubmed Data : CMAJ. 2006 Jun 20;174(13):1843-4. PMID: 16785458

Article Published Date : Jun 20, 2006

Study Type : Human Study

Additional Links

Diseases : Hypertension: Pulmonary, Premature Birth, Preterm Infants: Patent Ductus Arteriosus (PDA)

Problem Substances : Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Hypertensive

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Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery.Dec 31, 2019

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Pubmed Data : Rev Fac Cien Med Univ Nac Cordoba. 2020 12 1 ;77(4):249-253. Epub 2020 Dec 1. PMID: 33351387

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Cell Mol Med. 2020 Dec 8. Epub 2020 Dec 8. PMID: 33295020

Article Published Date : Dec 07, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension.Jan 31, 2021

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Pubmed Data : Biochim Biophys Acta Mol Basis Dis. 2023 Aug ;1869(6):166753. Epub 2023 May 13. PMID: 37187449

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Heart Failure, Hypertension: Pulmonary, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

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Cannabidiol ameliorates monocrotaline-induced pulmonary hypertension in rats. Sep 24, 2020

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Pubmed Data : Hua Xi Yi Ke Da Xue Xue Bao. 1996 Mar;27(1):68-70. PMID: 9208624

Article Published Date : Mar 01, 1996

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Hypertension: Pulmonary, Right Ventricular Hypertrophy

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l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats.Feb 26, 2008

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Pubmed Data : Eur J Pharmacol. 2008 Feb 26;581(1-2):148-56. Epub 2007 Nov 28. PMID: 18164288

Article Published Date : Feb 26, 2008

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Nitric Oxide Enhancer

[+]

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 Mar;33(5):544-9. PMID: 18536380

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Puerarin

Diseases : Hypertension: Pulmonary, Oxidative Stress

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The present study demonstrates that Ocimum sanctum has therapeutic ability against monocrotaline-induced pulmonary hypertension.Apr 16, 2018

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Pubmed Data : Medicines (Basel). 2018 Apr 17 ;5(2). Epub 2018 Apr 17. PMID: 29673152

Article Published Date : Apr 16, 2018

Study Type : Animal Study

Additional Links

Substances : Holy Basil

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

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The results revealed that honokiol can alleviate autophagy and pulmonary arterial hypertension.Feb 28, 2019

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Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2022 May 20 ;42(5):718-723. PMID: 35673916

Article Published Date : May 19, 2022

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Urolithin A protects against hypoxia-induced pulmonary hypertension.Jul 27, 2024

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Pubmed Data : Int J Mol Sci. 2024 Jul 28 ;25(15). Epub 2024 Jul 28. PMID: 39125817

Article Published Date : Jul 27, 2024

Study Type : Animal Study

Additional Links

Substances : Urolithin A

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

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View the Evidence: 113 Abstracts with Hypertension: Pulmonary Research

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A case of pulmonary hypertension following L-lysine ibuprofen therapy has been reported in a preterm infant with patent ductus arteriosus.Jun 20, 2006

Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery.Dec 31, 2019

In patients with moderate to severe portopulmonary hypertension, beta-blockers are associated with significant worsening in exercise capacity and pulmonary hemodynamics.Jan 01, 2006

Iron supplementation has a beneficial effect on hypoxic pulmonary hypertension.Oct 07, 2009

Use of SSRIs in the second half of pregnancy was associated with the risk of persistent pulmonary hypertension.Nov 21, 2016

Polyphenol antioxidant treatment may provide an adjunctive action to alleviate pulmonary vascular remodeling.Dec 31, 2016

These findings indicate that DHA activates PASMC KCa channels leading to vasorelaxation in pulmonary hypertension.Aug 17, 2016

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2021

Vitamin C deficiency-induced pulmonary arterial hypertension.Jan 31, 2020

Wogonin may be a promising treatment against pulmonary hypertension.Jun 26, 2024

Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function Nov 30, 2020

2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension.Sep 23, 2018

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.Nov 01, 2006

Allicin may be an alternative in treating pulmonary arterial hypertension.Aug 18, 2023

Andrographolide attenuates established pulmonary hypertension.Jan 29, 2021

Anti-inflammatory effect of allicin associated with fibrosis in pulmonary arterial hypertension.Aug 09, 2021

Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure. Mar 01, 2010

Antioxidants attenuate chronic hypoxic pulmonary hypertension.Nov 01, 1998

Apigenin attenuates pulmonary hypertension.Jan 09, 2020

Apple polyphenol relieves hypoxia-induced pulmonary arterial hypertension.Oct 31, 2018

Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway.Dec 31, 2020

Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.Dec 07, 2020

Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension.Jan 31, 2021

Astragaloside IV improves pulmonary arterial hypertension.Feb 09, 2023

Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension.Oct 11, 2023

Astragalus appears to have an inhibitory effect on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Jan 01, 2008

Berberine attenuates pulmonary arterial hypertension.Aug 04, 2018

Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension.Sep 12, 2019

Caffeic acid phenethyl ester rescues pulmonary arterial hypertension.Mar 21, 2019

Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway.Jul 31, 2023

Cannabidiol ameliorates monocrotaline-induced pulmonary hypertension in rats. Sep 24, 2020

Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension.Mar 31, 2024

Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.Feb 01, 1995

Celastrol attenuates the remodeling of pulmonary vascular and right ventricular in monocrotaline-induced pulmonary arterial hypertension.Jan 31, 2022

Chrysin alleviates monocrotaline-induced pulmonary hypertension.May 31, 2020

Crocin may play a protective role in MCT-induced PAH rats by alleviating inflammatory response.Dec 01, 2021

Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice.Jun 02, 2024

Curcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.Aug 01, 2006

Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline.Apr 30, 2021

Danshensu might be suitable for clinical treatment of early-stage hypoxic pulmonary hypertension.Apr 30, 2020

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension.Aug 05, 2003

Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats.Mar 01, 1997

Dehydroepiandrosterone upregulates inhibits hypoxic pulmonary hypertension.Jun 01, 2007

Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism.May 27, 2019

Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension.Nov 30, 1995

Eicosapentaenoic acid may have a therapeutic role in attenuating pulmonary hypertension. Jun 25, 2010

Electroacupuncture protects against hypoxia-induced pulmonary hypertension.May 01, 2010

Folic acid and d-ribose partially prevent right ventricular hypertrophy in rats. Sep 01, 2007

Genistein attenuates low temperature induced pulmonary hypertension in broiler chicks by modulating endothelial function.Dec 15, 2010

Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension, right ventricular hypertrophy, and pulmonary vascular remodeling in rats.Jan 01, 2006

Gingko biloba reduces hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Dec 01, 1996

Ginsenoside Rb1 is a promising candidate for pulmonary hypertension prevention.Nov 30, 2020

Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension.Jun 30, 2024

Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension.Jul 31, 2023

Ginsenosides have promising therapeutic potential for pulmonary hypertension.Jun 30, 2016

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Grape seed procyanidin suppresses inflammation caused by cigarette smoke.Sep 29, 2019

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.Feb 29, 2020

Isoliquiritigenin attenuates monocrotaline-induced pulmonary hypertension.Dec 31, 2018

Isoquercitrin protects against pulmonary hypertension Feb 28, 2017

Kaempferol ameliorates pulmonary vascular remodeling in chronic hypoxia-induced pulmonary hypertension.Apr 30, 2023

L-arginine ameliorates hypoxic pulmonary hypertension.Jun 01, 2009

L-arginine compares favorably with calcium channel blockers in the treatment of hypoxic pulmonary hypertension and right ventricular hypertrophy. Dec 01, 1994

L-arginine has a protective effect against hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in rats. Mar 01, 1996

l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats.Feb 26, 2008

L-argining may attenuate experimentally-induced pulmonary artery hypertension in rats. Mar 09, 2010

L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets.Sep 01, 2009

Luteolin ameliorates hypoxia-induced pulmonary hypertension.Aug 31, 2022

Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension.Nov 30, 2018

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension.Nov 26, 2019

N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia.May 27, 2005

Hypertension: Pulmonary

View the Evidence:
113 Abstracts with Hypertension: Pulmonary Research