Iron Overload

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19 Substances Researched for Iron Overload
NameACCKFocus
Green Tea313Locked
Rosemary110Locked
Curcumin66Locked
Ashwagandha12Locked
Cannabidiol 12Locked
Fermented Foods and Beverages12Locked
Papaya12Locked
Papaya: Fermented12Locked
Vitamin E12Locked
Astaxanthin11Locked
Carotenoids11Locked
Chinese Skullcap 11Locked
EGCG (Epigallocatechin gallate)11Locked
Isoliquiritigenin11Locked
Licorice11Locked
Milk Thistle11Locked
Polyphenols11Locked
Vitamin C11Locked
beta-Carotene11Locked
Related Topics

Iron Overload is a Sub of the following Topic

View the Evidence:
46 Abstracts with Iron Overload Research

[+]

Curcuminoids supplementation ameliorates iron overload, oxidative stress, hypercoagulability, and inflammation.Jan 02, 2021

Pubmed Data : Ann Hematol. 2021 Jan 3. Epub 2021 Jan 3. PMID: 33388858
Article Published Date : Jan 02, 2021
Study Type : Human Study
Additional Links
Substances : Curcuminoids
Diseases : Inflammation, Iron Overload, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Green tea and rosemary added to foods reduces non-heme iron absorption. Mar 01, 2001

Pubmed Data : Am J Clin Nutr. 2001 Mar;73(3):607-12. PMID: 11237939
Article Published Date : Mar 01, 2001
Study Type : Human Study
Additional Links
Substances : Green Tea, Rosemary
Diseases : Iron Overload
Additional Keywords : Iron Chelation
[+]

Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome.Jan 10, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut. 2017 11 ;66(11):1956-1967. Epub 2017 Aug 3. PMID: 28774885
Article Published Date : Jan 10, 2017
Study Type : Human Study
Additional Links
Substances : Galacto-oligosaccharides
Diseases : Iron Overload
Pharmacological Actions : Gastrointestinal Agents
[+]

Red meat consumption was significantly positively associated with ferritin concentrations and myocardial infarction risk.Dec 31, 2017

Pubmed Data : Am J Clin Nutr. 2018 Jan 1 ;107(1):113-119. PMID: 29381787
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases, Iron Overload
Additional Keywords : Risk Factors
Problem Substances : Meat
[+]

The results of this study indicated that supplementation with 600 mg/d alpha lipoic acid may decrease serum ferritin in β-Thalassemia major.Feb 01, 2021

Pubmed Data : Int J Clin Pract. 2021 Feb 2:e14062. Epub 2021 Feb 2. PMID: 33527721
Article Published Date : Feb 01, 2021
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Iron Overload, Thalassemia
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

Nobiletin could alleviate iron overload damage in vascular endothelium.Jan 29, 2020

Pubmed Data : Biol Trace Elem Res. 2020 Jan 30. Epub 2020 Jan 30. PMID: 32002792
Article Published Date : Jan 29, 2020
Study Type : Human In Vitro
Additional Links
Substances : Nobiletin
Diseases : Iron Overload
Pharmacological Actions : Antioxidants, Nitric Oxide Enhancer
[+]

Alpha-lipoic acid possesses excellent iron chelating properties.Jan 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Jan 31 ;20(3). Epub 2019 Jan 31. PMID: 30708965
Article Published Date : Jan 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Iron Overload
Pharmacological Actions : Iron Chelating Agents
[+]

Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.Sep 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Psychiatry. 2018 Sep 3 ;8(1):176. Epub 2018 Sep 3. PMID: 30177808
Article Published Date : Sep 02, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Cognitive Decline/Dysfunction, Iron Overload
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Ashwaganda's hepatoprotective properties protects against iron overload toxicity.Nov 01, 2000

Pubmed Data : Phytother Res. 2000 Nov;14(7):568-70. PMID: 11054855
Article Published Date : Nov 01, 2000
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Iron Overload
Pharmacological Actions : Hepatoprotective
[+]

Astragaloside IV protects against iron loading-induced abnormal differentiation of bone marrow mesenchymal stem cells.Jan 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Open Bio. 2021 Jan 14. Epub 2021 Jan 14. PMID: 33445204
Article Published Date : Jan 13, 2021
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Iron Overload, Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Mesenchymal Stem Cells
[+]

Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.Dec 31, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2021 01 1 ;410:115361. Epub 2020 Dec 4. PMID: 33285147
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Iron Overload, Macular Degeneration
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Berberine protects the liver and kidneys against ferrous sulfate-induced toxicity by reduction in lipid peroxidation and ability to chelate iron.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2018 May ;21(5):476-482. PMID: 29922427
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Iron Overload
Pharmacological Actions : Antioxidants, Hepatoprotective, Iron Chelating Agents, Renoprotective
[+]

Caffeic acid protects against iron-induced cardiotoxicity.Jun 05, 2020

Pubmed Data : Biol Trace Elem Res. 2020 Jun 6. Epub 2020 Jun 6. PMID: 32506180
Article Published Date : Jun 05, 2020
Study Type : Animal Study
Additional Links
Substances : Caffeic Acid
Diseases : Iron Overload
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload.Jan 31, 2014

Pubmed Data : Mol Neurobiol. 2014 Feb ;49(1):222-33. Epub 2013 Jul 28. PMID: 23893294
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Iron Overload, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Curcumin may represent a new horizon in managing iron overload-induced toxicity as well as in pathological diseases characterized by hepatic iron accumulation.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(7):e0134156. Epub 2015 Jul 31. PMID: 26230491
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Iron Overload, Myelodysplastic Syndromes, Oxidative Stress, Sickle Cell Anemia, Thalassemia
Pharmacological Actions : Antioxidants, Iron Chelating Agents
[+]

Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload.Oct 16, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Funct. 2018 Oct 17 ;9(10):5390-5401. PMID: 30272083
Article Published Date : Oct 16, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Anemia: Iron Deficiency, Iron Overload, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Ginkgetin may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.Dec 31, 2014

Pubmed Data : Free Radic Res. 2015 ;49(9):1069-80. Epub 2015 Jul 1. PMID: 25968939
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Iron Overload, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Iron Chelating Agents, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Grape seed proanthocyanidin extract as a naturally occurring prophylactic treatment for fluoride-induced hepatotoxicity associated with iron overload.Dec 31, 2017

Pubmed Data : J Toxicol Sci. 2018 ;43(5):311-319. PMID: 29743442
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Chemically-Induced Liver Damage, Fluoride Toxicity , Iron Overload
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Sodium Fluoride
[+]

Green tea decreases iron in plasma, eliminates lipid peroxidation in plasma and destroys formation of red blood cell reactive oxygen species. Jul 01, 2008

Pubmed Data : Med Chem. 2008 Jul;4(4):365-70. PMID: 18673149
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Green Tea
Diseases : Iron Overload, Thalassemia
Pharmacological Actions : Antioxidants
[+]

Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in a model of Parkinson's disease.Jan 04, 2018

Pubmed Data : Chem Biol Interact. 2018 Jan 5 ;279:177-186. Epub 2017 Dec 2. PMID: 29191452
Article Published Date : Jan 04, 2018
Study Type : Insect Study
Additional Links
Substances : Hesperidin
Diseases : Iron Overload, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.May 31, 2020

Pubmed Data : Life Sci. 2020 Jun 1 ;250:117573. Epub 2020 Mar 21. PMID: 32209423
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Iron Overload, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Krill oil might be a new candidate for treatment of iron overload-induced toxicity.Jan 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Feb ;27(4):3950-3961. Epub 2019 Dec 10. PMID: 31823254
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Krill
Diseases : Iron Overload, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

M. officinalis demonstrated dose dependant in-vitro iron chelating ability.Nov 30, 2016

Pubmed Data : Drug Res (Stuttg). 2016 Dec ;66(12):618-627. Epub 2016 Sep 14. PMID: 27626608
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Yellow Sweet Clover (Melilotus officinalis)
Diseases : Iron Overload
Pharmacological Actions : Iron Chelating Agents
Additional Keywords : Plant Extracts
[+]

Mangiferin could increase urinary iron excretion and to decrease iron accumulation in liver and heart.Sep 05, 2018

Pubmed Data : Drug Res (Stuttg). 2018 Sep 6. Epub 2018 Sep 6. PMID: 30189460
Article Published Date : Sep 05, 2018
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Iron Overload
[+]

Phyllostachys nigra stem can exert a hepatoprotective effect against iron overload-induced acute liver damage due to its antioxidant properties.Jan 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Jan 8 ;11(1). Epub 2019 Jan 8. PMID: 30626086
Article Published Date : Jan 07, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bamboo
Diseases : Chemically-Induced Liver Damage, Iron Overload, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
[+]

Protective effects of grape seed proanthocyanidins against iron overload-induced renal oxidative damage in rats.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Trace Elem Med Biol. 2020 Jan ;57:126407. Epub 2019 Sep 18. PMID: 31570250
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Iron Overload, Kidney Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
Additional Keywords : Proanthocyanidins
[+]

Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Feb ;122:109690. Epub 2019 Nov 28. PMID: 31786468
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Iron Overload
[+]

Study of the protective effects of Katha (Heartwood Extract of Acacia catechu) in liver damage induced by iron overload.Dec 31, 2012

Pubmed Data : J Environ Pathol Toxicol Oncol. 2013 ;32(3):229-40. PMID: 24266409
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Acacia catechu
Diseases : Chemically-Induced Liver Damage, Iron Overload, Lipid Peroxidation
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

The antioxidant effect of fermented papaya preparation involves iron chelation.Mar 31, 2012

Pubmed Data : J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):203-10. PMID: 22824747
Article Published Date : Mar 31, 2012
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Papaya, Papaya: Fermented
Diseases : Iron Overload
Pharmacological Actions : Antioxidants, Iron Chelating Agents
[+]

These results suggest beneficial effects of Tetrahydrocurcumin and L1 on iron-induced oxidative stress, hypertension, and vascular dysfunction.Nov 30, 2016

Pubmed Data : Vascul Pharmacol. 2016 Dec ;87:199-208. Epub 2016 Oct 3. PMID: 27713040
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Tetrahydrocurcumin
Diseases : Hypertension, Iron Overload, Oxidative Stress
Pharmacological Actions : Antihypertensive Agents
[+]

Vitamin E attenuates oxidative stress associated with iron overload in rats. Feb 15, 1999

Pubmed Data : Toxicology. 1999 Feb 15;132(2-3):179-86. PMID: 10433381
Article Published Date : Feb 15, 1999
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Iron Overload, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

White tea consumption slightly reduces iron absorption in animals.Aug 31, 2011

Pubmed Data : J Physiol Biochem. 2011 Sep ;67(3):331-7. Epub 2011 Feb 19. PMID: 21336649
Article Published Date : Aug 31, 2011
Study Type : Animal Study
Additional Links
Substances : White Tea
Diseases : Iron Overload
Pharmacological Actions : Iron Chelating Agents
Additional Keywords : Plant Extracts
[+]

Astaxanthin reduces iron-induced oxidative damage. Oct 19, 2001

Pubmed Data : Biochem Biophys Res Commun. 2001 Oct 19;288(1):225-32. PMID: 11594777
Article Published Date : Oct 19, 2001
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin, beta-Carotene, Carotenoids, Vitamin C
Diseases : Iron Overload, Iron Poisoning, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Curcumin is an iron chelator. - Article 1. Apr 01, 2006

Pubmed Data : Free Radic Biol Med. 2006 Apr 1;40(7):1152-60. PMID: 16545682
Article Published Date : Apr 01, 2006
Study Type : Commentary
Additional Links
Substances : Curcumin
Diseases : Iron Overload
[+]

Curcumin is an iron chelator. - Article 2.Nov 01, 2004

Pubmed Data : J Eur Acad Dermatol Venereol. 2004 Nov;18(6):649-53. PMID: 18815282
Article Published Date : Nov 01, 2004
Study Type : Commentary
Additional Links
Substances : Curcumin
Diseases : Iron Overload, Iron Poisoning
[+]

Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.Jan 01, 2009

Pubmed Data : Liver Int. 2009 Jan;29(1):63-72. Epub 2008 May 19. PMID: 18492020
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Iron Overload, Iron Poisoning, Oxidative Stress
Pharmacological Actions : Hepatoprotective
[+]

Gastrodin can inhibit H2O2-induced ferroptosis through its antioxidative effect in C6 cells.Dec 31, 2019

Pubmed Data : Biol Pharm Bull. 2020 ;43(3):480-487. PMID: 32115506
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Hydrogen Peroxide Induced Toxicity, Iron Overload, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Isoliquiritigenin (ILQ), a flavonoid compound found within licorice, protects mitochondria against iron-catalyzed oxidative stress. Dec 21, 2009

Pubmed Data : Biochem Pharmacol. 2009 Dec 21. Epub 2009 Dec 21. PMID: 20026081
Article Published Date : Dec 21, 2009
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin, Licorice
Diseases : Iron Overload, Iron Poisoning
Pharmacological Actions : Antioxidants
[+]

Polyphenols such as curcumin and EGCG from green tea may chelate out iron from the Alzheimers brain. Aug 01, 2007

Pubmed Data : Prog Neurobiol. 2007 Aug;82(6):348-60. Epub 2007 Jun 19. PMID: 17659826
Article Published Date : Aug 01, 2007
Study Type : Commentary
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Green Tea, Polyphenols
Diseases : Alzheimer's Disease, Iron Overload
[+]

Protective effect of astragaloside IV on hepatic injury induced by iron overload.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:3103946. Epub 2019 Jul 25. PMID: 31428632
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Chemically-Induced Liver Damage, Iron Overload
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective
[+]

Quercetin protects the vascular endothelium against iron overload damages.Feb 04, 2020

Pubmed Data : Eur J Pharmacol. 2020 Feb 5 ;868:172885. Epub 2019 Dec 20. PMID: 31870832
Article Published Date : Feb 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Iron Overload
Pharmacological Actions : Vasoprotective
[+]

Silybin, a compound from within milk thistle, is strong iron chelator. Jun 01, 2004

Pubmed Data : Fitoterapia. 2004 Jun;75(3-4):375-7. PMID: 11410232
Article Published Date : Jun 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Milk Thistle
Diseases : Cooley's Anemia, Iron Overload, Iron Poisoning
Additional Keywords : Iron Chelation
[+]

The beneficial effects of statin drugs be related to their action on iron metabolism. Oct 23, 2012

Pubmed Data : QJM. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097387
Article Published Date : Oct 23, 2012
Study Type : Review
Additional Links
Diseases : Atherosclerosis, Iron Overload
Additional Keywords : Cholesterol Myth
[+]

The major bioactive compound found within Chinese skullcap is an iron chelator and radical scavenger. Mar 01, 2009

Pubmed Data : J Inorg Biochem. 2009 Mar;103(3):326-32. Epub 2008 Nov 19. PMID: 19108897
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap
Diseases : Iron Overload, Iron Poisoning
Additional Keywords : Iron Chelation
[+]

This study demonstrates that iron depletion causes toxicity for cancer stem cells.Dec 31, 2015

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2016 ;62(4):25-30. Epub 2016 Apr 30. PMID: 27188730
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Iron Overload
Additional Keywords : Cancer Stem Cells
[+]

Curcuminoids alleviate iron overload and lipid peroxidation in thalassemic mice. Sep 01, 2009

Pubmed Data : Med Chem. 2009 Sep 1.PMID:19534681
Article Published Date : Sep 01, 2009
Additional Links
Substances : Curcumin
Diseases : Iron Overload, Thalassemia

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