Kidney Damage: Chemically-Induced

Name	AC	CK
Cocoa	1	2
Curcumin	1	2
Dates	1	2
EGCG (Epigallocatechin gallate)	1	2
Ginger	1	2
Ginkgo biloba	1	2
Polyphenols	1	2
Pomegranate	1	2
Punicalagin	1	2
Rutin	1	2
Selenium	1	2
Sesame Seed Oil	1	2
Thymoquinone	1	2
Zinc	1	2

Name	AC	CK
Acrylamide	1	2
Aluminum	1	2
Arsenic	1	2
Cadmium	1	2
Cypermethrin	1	2
Gentamicin	1	2
Titanium Dioxide	1	2
Titanium Nanoparticles	1	2
Glyphosate	1	1
Roundup (herbicide)	1	1

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6-shogaol and could be a cost-effective candidate for the prevention and treatment of urolithiasis.May 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Chem Biol Interact. 2021 Aug 1 ;344:109529. Epub 2021 May 23. PMID: 34029542

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Kidney Damage: Chemically-Induced, Oxidative Stress

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

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Antioxidative and anti-inflammatory protective effects of β-caryophyllene against amikacin-induced nephrotoxicity.Dec 31, 2021

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:4212331. Epub 2022 Aug 26. PMID: 36062191

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : Antibiotic Toxicity , Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor

Problem Substances : Antibiotics

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Antioxidative, anti-inflammatory and anti-apoptotic action of ellagic acid against lead acetate induced testicular and hepato-renal oxidative damages.May 31, 2022

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Pubmed Data : Environ Pollut. 2022 Jun 1 ;302:119048. Epub 2022 Feb 24. PMID: 35219795

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Astragaloside IV may be a promising agent for the treatment of uremia toxin-induced injury. Sep 02, 2018

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Pubmed Data : J Biochem Mol Toxicol. 2021 Nov ;35(11):e22901. Epub 2021 Sep 2. PMID: 34472159

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Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752142

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Pubmed Data : Environ Toxicol. 2015 Apr 9. Epub 2015 Apr 9. PMID: 25858877

Article Published Date : Apr 08, 2015

Study Type : Animal Study

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Diseases : Acrylamide-induced toxicity, Aluminum Toxicity , Kidney Damage: Chemically-Induced

Additional Keywords : Synergistic Toxicity

Problem Substances : Acrylamide , Aluminum

Adverse Pharmacological Actions : Genotoxic, Inflammatory

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Coenzyme Q10 reduces the deleterious cellular side effects of lead acetate.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2021 Jan ;25(2):1016-1023. PMID: 33577057

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

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Dietary inclusion of Kolaviron could exert protective effects against renal toxicity resulting from B[a]P exposure.Mar 31, 2015

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Pubmed Data : Ren Fail. 2015 Apr ;37(3):497-504. Epub 2015 Jan 23. PMID: 25613738

Article Published Date : Mar 31, 2015

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Environmental level bisphenol A accelerates alterations of the reno-cardiac axis by the MAPK cascades in male diabetic rats.Jun 27, 2021

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Pubmed Data : Environ Pollut. 2021 Jun 28 ;287:117671. Epub 2021 Jun 28. PMID: 34435562

Ginger and zinc mixture protected against malathion induced toxicity to the liver and kidney.Feb 28, 2015

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Pubmed Data : Int J Immunopathol Pharmacol. 2015 Mar ;28(1):122-8. PMID: 25816415

Article Published Date : Feb 28, 2015

Study Type : Animal Study

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Substances : Ginger, Zinc

Diseases : Chemical Exposure, Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Additional Keywords : Malathion Toxicity, Zinc Chloride

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Ginger extracts could have a potent protective effects against nephrotoxicity induced by various toxicants.Jan 31, 2019

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Harmine protects mercuric chloride kidney-induced injury by antioxidant activity in male mice: a biochemical and histological study.Nov 30, 2020

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Pubmed Data : Res Pharm Sci. 2020 Dec ;15(6):541-550. Epub 2020 Nov 27. PMID: 33828597

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Harmine

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Mercury

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Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

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Pubmed Data : Open Access Maced J Med Sci. 2019 Feb 28 ;7(4):536-542. Epub 2019 Feb 27. PMID: 30894908

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Pubmed Data : Int J Prev Med. 2019 ;10:97. Epub 2019 Jun 7. PMID: 31360344

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Harmine

Diseases : Kidney Damage: Chemically-Induced, Nicotine/Tobacco Toxicity

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Renoprotective

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Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury.Oct 23, 2021

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Pubmed Data : J Sci Food Agric. 2021 Oct 24. Epub 2021 Oct 24. PMID: 34689333

Melatonin ameliorates renal dysfunction in glyphosate- and hard water-treated mice.Jul 31, 2022

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Pubmed Data : Ecotoxicol Environ Saf. 2022 Aug ;241:113803. Epub 2022 Jun 29. PMID: 36068739

NAC is an effective adjunct for preserving mitochondrial homeostasis and reducing remote effects of AKI in environments where BPA exposure is vulnerable.Oct 20, 2019

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Pubmed Data : Antioxidants (Basel). 2019 Oct 21 ;8(10). Epub 2019 Oct 21. PMID: 31640182

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Pubmed Data : J Oleo Sci. 2018 ;67(10):1339-1345. PMID: 30305562

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Ginger, Turmeric

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Adenosine deaminase inhibitor, Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Essential Oils

Problem Substances : Cadmium

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Nephroprotective effect of gastrodin against lead-induced oxidative stress and inflammation.Feb 28, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Res (Camb). 2021 Mar ;10(2):249-263. Epub 2021 Mar 23. PMID: 33884175

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Gastrodin

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

Problem Substances : Lead

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Nephroprotective effect of green tea, rosmarinic acid and rosemary on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute renal toxicity.Sep 30, 2019

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Pubmed Data : Biol Trace Elem Res. 2022 Jan 23. Epub 2022 Jan 23. PMID: 35066750

Article Published Date : Jan 22, 2022

Study Type : Animal Study

Additional Links

Substances : Selenium, Zinc

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

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Nephroprotective role of Beta vulgaris L. root extract against chlorpyrifos-induced renal injury in rats.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:3595761. Epub 2019 Nov 22. PMID: 31885644

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Beet

Diseases : Kidney Damage: Chemically-Induced, Pesticide Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Chlorpyrifos

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Pubmed Data : Biol Trace Elem Res. 2017 May 31. Epub 2017 May 31. PMID: 28567583

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Pubmed Data : J Cell Physiol. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31898818

Article Published Date : Jan 02, 2020

Study Type : Animal Study

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Substances : Lemon, Orange

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Fibrotic, Renoprotective

Problem Substances : Ochratoxin A

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Renal protective effects of grape seed extract treatment against eltroxin-induced hyperthyroidism, kidney damage, and oxidative stress.Apr 30, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 May ;27(15):17963-17971. Epub 2020 Mar 12. PMID: 32166689

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Hyperthyroidism, Kidney Damage: Chemically-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

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Role of fucoxanthin towards cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities.Nov 30, 2021

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Pubmed Data : Bioengineered. 2021 Dec ;12(1):7235-7247. PMID: 34569908

Article Published Date : Nov 30, 2021

Study Type : Animal Study

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Substances : Fucoxanthin

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Cadmium

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Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity.Dec 16, 2018

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Pubmed Data : Hum Exp Toxicol. 2018 Dec 17:960327118818246. Epub 2018 Dec 17. PMID: 30558456

Article Published Date : Dec 16, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Selenium, Thymoquinone

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Arsenite

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Rosemary is efficient in the prevention of kidney function against carbon tetrachloride-toxicity.Nov 29, 2018

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Pubmed Data : Arch Physiol Biochem. 2018 Nov 30:1-8. Epub 2018 Nov 30. PMID: 30501137

Article Published Date : Nov 29, 2018

Study Type : Animal Study

Additional Links

Substances : Rosemary

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

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Spirulina is an important protective source against kidney impairments.Dec 31, 2017

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Pubmed Data : EXCLI J. 2018 ;17:215-232. Epub 2018 Mar 2. PMID: 29743860

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Kidney Damage: Chemically-Induced, Lead Poisoning

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Lead

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Study on the efficacy and mechanism of Lycium barbarum polysaccharide against lead-induced renal iInjury.Aug 24, 2021

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This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing gold nanoparticles toxicity.Dec 31, 2019

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Pubmed Data : Biotech Histochem. 2020 Mar 24:1-8. Epub 2020 Mar 24. PMID: 32207631

Article Published Date : Mar 23, 2020

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Thymoquinone showed protective effects against HgCl2-induced nephrotoxicity.Feb 28, 2022

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Pubmed Data : ACS Omega. 2022 Mar 1 ;7(8):7370-7379. Epub 2022 Feb 18. PMID: 35252727

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:2474831. Epub 2018 Jan 30. PMID: 29636837

Pubmed Data : Toxicon. 2019 Jul 26. Epub 2019 Jul 26. PMID: 31356822

Article Published Date : Jul 25, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Ochratoxin A

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Astragaloside IV alleviates tacrolimus-induced chronic nephrotoxicity.Dec 31, 2019

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Pubmed Data : Int J Environ Res Public Health. 2014 ;11(2):2125-47. Epub 2014 Feb 20. PMID: 24562182

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Diseases : Chronic Kidney Disease of Unknown Etiology (CKDu), Kidney Damage: Chemically-Induced, Kidney Diseases

Problem Substances : Glyphosate, Roundup (herbicide)

Adverse Pharmacological Actions : Nephrotoxic

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Hesperidin protects liver and kidney against sodium fluoride-induced toxicity.Sep 14, 2021

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Pubmed Data : Life Sci. 2021 Sep 15 ;281:119730. Epub 2021 Jun 17. PMID: 34147482

Pubmed Data : Saudi Med J. 2011 Aug ;32(8):797-805. PMID: 21858388

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Pubmed Data : J Biomed Sci. 2019 Jan 9 ;26(1):5. Epub 2019 Jan 9. PMID: 30621719

Article Published Date : Jan 08, 2019

Study Type : Review

Additional Links

Substances : Rosemary

Diseases : Cancers: All, Inflammation, Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Antiviral Agents, Neuroprotective Agents, Prophylactic Agents, Renoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Lead

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Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway.Mar 31, 2021

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Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr ;242:108945. Epub 2020 Dec 3. PMID: 33278595

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View the Evidence: 198 Abstracts with Kidney Damage: Chemically-Induced Research

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Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus.Nov 25, 2019

The current study reports higher urinary herbicide levels among sugarcane farmers in Warunagama and Rahathangama.Mar 21, 2021

Lactoferrin attenuated urban particulate matter-induced nephrotoxicity.Dec 13, 2022

Acute kidney injury and hepatitis associated with energy drink consumption: a case report.Jan 28, 2020

Acute kidney injury following exposure to formaldehyde-free hair-straightening products.Apr 30, 2022

Protective effect of hydroxysafflor yellow A on cyclosporin A-induced renal oxidative stress.Dec 31, 2021

Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis Feb 22, 2022

The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage.Apr 29, 2020

"Pomegranate Extract Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Reducing Oxidative Stress."Nov 25, 2012

6-shogaol and could be a cost-effective candidate for the prevention and treatment of urolithiasis.May 31, 2021

Aged garlic extract rescues ethephon-induced kidney damage.Jan 31, 2021

Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract.Jun 11, 2020

Ameliorative effect of virgin olive oil against nephrotoxicity following sub-chronic administration of ethephon.Aug 31, 2020

Ameliorative effects of propolis and royal jelly against CCl4 -induced hepatotoxicity and nephrotoxicity.Nov 22, 2022

Ameliorative role of diallyl disulfide against glycerol-induced nephrotoxicity.Dec 31, 2020

Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity.Jul 31, 2021

Antioxidative and anti-inflammatory protective effects of β-caryophyllene against amikacin-induced nephrotoxicity.Dec 31, 2021

Antioxidative, anti-inflammatory and anti-apoptotic action of ellagic acid against lead acetate induced testicular and hepato-renal oxidative damages.May 31, 2022

Apigenin can be used as a promising agent to reduce the renal adverse reaction of Imipenem in clinic.May 27, 2020

Apigenin protects from hepatorenal damage caused by lead acetate.Dec 21, 2022

Apple cider vinegar has the therapeutic potential to protect against renal impairment and attendant malfunction.Nov 30, 2020

AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance.Jun 07, 2021

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Astragaloside IV may be a promising agent for the treatment of uremia toxin-induced injury. Sep 02, 2018

Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.Feb 28, 2022

Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E.Dec 22, 2019

Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney.Oct 31, 2021

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney.Dec 31, 2020

Black tea theaflavins could protect against liver and kidney damage.May 17, 2021

Cacao polyphenol extracts could protect animal kidneys against carbon tetrachloride.Dec 31, 2014

CAPE seems to be effective agent and may be related to its potent antioxidant, anti-inflammatory properties and action as an Nrf2 activator.Aug 31, 2017

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Chronic exercise provides renal protective effects with upregulation of fatty acid oxidation in the kidney of high fructose-fed rats.Feb 09, 2020

Chrysin attenuates sodium arsenite-induced nephrotoxicity in rats by suppressing oxidative stress and inflammation.Sep 26, 2021

Co-exposure to aluminum and acrylamide exhibited synergism and more pronounced toxic effects compared with their individual effects.Apr 08, 2015

Coenzyme Q10 reduces the deleterious cellular side effects of lead acetate.Dec 31, 2019

Crocetin attenuates the oxidative stress, inflammation and apoptosis in arsenic trioxide-induced nephrotoxic rats.Sep 08, 2020

Crocin has protective activities against ethanol toxic effects in the liver and kidney.Dec 31, 2019

Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis.Mar 16, 2021

Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury.Jul 16, 2021

Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity.Dec 31, 2020

Dietary inclusion of Kolaviron could exert protective effects against renal toxicity resulting from B[a]P exposure.Mar 31, 2015

Diosgenin protects against kidney injury and mitochondrial apoptosis induced by 3-MCPD.Dec 31, 2020

Diosmin protects against trichloroethylene-induced renal injury.Jul 31, 2013

Disruption of kidney metabolism in rats after subchronic combined exposure to low-dose cadmium and chlorpyrifos.Nov 29, 2018

Dose-dependent renoprotective impact of Lactoferrin against glycerol-induced rhabdomyolysis and acute kidney injury.May 16, 2022

Early kidney damage induced by subchronic exposure to Particulate matter.Jan 11, 2016

Effects of delta-tocotrienol on ochratoxin A-induced nephrotoxicity.Oct 31, 2018

EGCG could attenuate cadmium induced chronic renal injury.Jul 25, 2016

Ellagic acid provides protection against lead-induced nephrotoxicity to a significant degree.Dec 31, 2020

Environmental level bisphenol A accelerates alterations of the reno-cardiac axis by the MAPK cascades in male diabetic rats.Jun 27, 2021

Exposure to phthalates DEHP and DINP May lead to oxidative damage and lipidomic disruptions in mouse kidney.Apr 30, 2021

Fermented camel milk prevents carbon tetrachloride induced acute injury in kidney of mice.Apr 30, 2018

Feverfew extract had potent nephroprotective effects against oxygen free radicals produced through carbon tetrachloride metabolism.Jun 30, 2018

Flaxseed lignan-Secoisolariciresinol diglucoside may be recommended for clinical trials in the treatment of kidney disorders caused by exposure to mercury.Sep 05, 2019

Galangin attenuates cadmium-evoked nephrotoxicity.Jun 30, 2022

Gallic acid could alleviate the noxious effects of paraquat on the antioxidant defense system and renal tissue.Jul 29, 2020

Gallic and hesperidin ameliorate electrolyte imbalances in AlCl3-induced nephrotoxicity.Dec 31, 2021

Ginger and zinc mixture protected against malathion induced toxicity to the liver and kidney.Feb 28, 2015

Ginger extracts could have a potent protective effects against nephrotoxicity induced by various toxicants.Jan 31, 2019

Ginger showed a protection role in glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia.Jun 29, 2022

Ginkgo biloba extract had a protective effect on lead-induced morphometric changes in the kidneys of albino rats.Dec 31, 2016

Ginkgo biloba extract reverses the renal effects of titanium dioxide nanoparticles in adult male rats.Dec 31, 2015

Ginseng may have protective effects against hepatic and renal malathion-induced toxicity.May 22, 2022

Grape seed extract has beneficial effects against dexamethasone-induced hepatic and renal dysfunction.Apr 10, 2017

Grape seed procyanidin extract attenuate sodium fluoride-induced oxidative damage and apoptosis in rat kidneys.Jun 19, 2020

Harmine protects mercuric chloride kidney-induced injury by antioxidant activity in male mice: a biochemical and histological study.Nov 30, 2020

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

Hesperidin has a protective effect on sodium arsenite-induced nephrotoxicity and hepatotoxicity.Jul 30, 2018

Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity.Apr 27, 2021

Hesperidin protects rats' liver and kidney from oxidative damage and physiological disruption induced by nickel oxide nanoparticles.Dec 31, 2021

Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice.Dec 31, 2022

Kidney Damage: Chemically-Induced

View the Evidence:
198 Abstracts with Kidney Damage: Chemically-Induced Research