Kidney Damage: Drug-Induced

Name	AC	CK
Vitamin C	3	13
Silymarin	1	10
Flavonoids	5	9
Curcumin	4	8
Grape Seed Extract	3	6
Melatonin	3	6
NAC (N-acetyl-L-cysteine)	3	6
Royal Jelly	3	6
Astaxanthin	2	4
Berberine	2	4
Garlic	2	4
Ginkgo biloba	2	4
Green Tea	2	4
Naringenin	2	4
Nigella sativa (aka Black Seed)	2	4
Thymoquinone	2	4
Vitamin D	2	4
Coenzyme Q10	2	3
Polyphenols	2	3
Quercetin	2	3
Allicin	1	2
Amla Fruit	1	2
Andrographis	1	2
Apigenin	1	2
Apocynin	1	2
Artichoke	1	2
Asiatic Acid	1	2
Bacopa	1	2
Basil	1	2
Bitter Melon	1	2
Chrysin	1	2
Citrus naringin	1	2
Coconut Oil	1	2
Corn Silk	1	2
Crocin	1	2
Dandelion	1	2
Echinacea	1	2
Ferulic acid	1	2
Garcinia kola	1	2
Germanium	1	2
Glycyrrhizin	1	2
Hesperidin	1	2
Hydrogen Water	1	2
Mangiferin	1	2
Moringa oleifera	1	2
Nobiletin	1	2
Oleuropein	1	2
Omega-3 Fatty Acids	1	2
Orange: Mandarin	1	2
Organosulfur Compounds	1	2
Paeonol	1	2
Parsley	1	2
Poria cocos	1	2
Pycnogenol (Pine Bark)	1	2
Resveratrol	1	2
Rhubarb	1	2
Rosmarinic acid	1	2
Rutin	1	2
Scopoletin	1	2
Silibinin	1	2
Silver (nanoparticles)	1	2
Spirulina	1	2
Tanshinone IIA	1	2
Taurine	1	2
Tongkat Ali	1	2
Turmeric	1	2
Urolithin A	1	2
Vitamin E	1	2
Whey	1	2
White Clover	1	2
Chicoric Acid	1	1
Ginsenosides	1	1
Isoflavones	1	1
Leonurine	1	1
Red Wine Extract	1	1
Saffron	1	1
Salvia miltiorrhiza	1	1

Name	AC	CK
Acetaminophen	16	32
Paracetamol	15	30
Fenofibrates	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	3	15
Antibiotics	3	14
Bisphosphonates	3	14
Diclofenac	7	14
Vancomycin	3	14
Zoledronic Acid	3	14
Statin Drugs	2	11
Atorvastatin	1	10
Cisplatin	1	10
Proton-Pump Inhibitors	1	10
Methotrexate	3	6
Aspirin	2	4
Morphine	2	4
Dexamethasone	1	3
Lovastatin	1	3
Naproxen	1	3
Simvastatin	1	3
Varenicline (trade name Chantix)	1	3
Antiretroviral Drugs	1	2
Celecoxib	1	2
Cyclosporine	1	2
Deltamethrin	1	2
Ibuprofen	1	2
Isoproterenol	1	2
Methylprednisolone	1	2
Ibandronate	1	1
Pamidronate	1	1
Tacrolimus	1	1

Name	AC	CK	Focus
Exercise: HIIT	1	2

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Cisplatin-associated severe acute kidney injury occurs in 20% of the patients and has a negative impact on long-term renal function and patient survival.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sr Care Pharm. 2019 May 1 ;34(5):325-333. PMID: 31054591

Article Published Date : Apr 30, 2019

Study Type : Human Study

Additional Links

Diseases : Kidney Damage: Drug-Induced

Additional Keywords : Increased Risk

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Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients.Sep 22, 2024

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 23. Epub 2024 Sep 23. PMID: 39311921

Article Published Date : Sep 22, 2024

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Antibiotic Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Antibiotics

[+]

Proton pump inhibitors use is associated with a higher risk of incident chronic kidney disease.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Wien Klin Wochenschr. 1996 ;108(11):334-7. PMID: 8767987

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Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

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Pubmed Data : J Biochem. 2020 Sep 24. Epub 2020 Sep 24. PMID: 32970799

Pubmed Data : Food Funct. 2019 Aug 1 ;10(8):4593-4607. Epub 2019 Jul 10. PMID: 31289794

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Ferulic acid

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

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Galangin provides significant protection against acetaminophen induced liver and kidney damage.Oct 31, 2015

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Pubmed Data : J Med Food. 2015 Nov ;18(11):1187-97. Epub 2015 Jun 4. PMID: 26501381

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Pubmed Data : Ultrastruct Pathol. 2021 Jan 11:1-10. Epub 2021 Jan 11. PMID: 33423596

Article Published Date : Jan 10, 2021

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Renoprotective

[+]

Green tea has a protective effect against Ibuprofen induced glomerular atrophy in the kidney.Aug 31, 2018

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Pubmed Data : J Coll Physicians Surg Pak. 2018 Sep ;28(9):659-662. PMID: 30158028

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Green Tea

Diseases : Ibuprofen Toxicity, Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Ibuprofen

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Hepato and Nephro protective potentials of lyophilized juice of Citrus reticulata L. fruit against paracetamol induced toxicity in rats.Apr 30, 2024

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Pubmed Data : Pak J Pharm Sci. 2024 May ;37(3):553-562. PMID: 39340846

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PeerJ. 2016 ;4:e2127. Epub 2016 Jul 7. PMID: 27441110

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

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[+]

Nephroprotective effect of vitamin D against levofloxacin-induced renal injury.Jun 30, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Ayub Med Coll Abbottabad. 2021 Jan-Mar;33(1):39-43. PMID: 33774952

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Aspirin-Induced Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Aspirin

[+]

Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.Sep 30, 2018

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Pubmed Data : J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID: 30266114

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Aspirin-Induced Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Aspirin

[+]

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

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Pubmed Data : J Biochem Mol Toxicol. 2019 Nov 27:e22427. Epub 2019 Nov 27. PMID: 31777137

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2022 Jun 4 ;152:113225. Epub 2022 Jun 4. PMID: 35671584

Article Published Date : Jun 03, 2022

Study Type : Animal Study

Additional Links

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Diclofenac

[+]

Physiological and histopathological study on the influence of Ocimum basilicum leaves extract on thioacetamide-induced nephrotoxicity.Jun 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Kidney Dis. 2022 Mar ;16(2):108-114. PMID: 35489079

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2023 Oct 12 ;59(10). Epub 2023 Oct 12. PMID: 37893532

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:8400496. Epub 2022 Jun 26. PMID: 35795279

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

[+]

Statin drugs have been linked to rhabdomyolysis, myositis and kidney failure. Oct 21, 2011

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Pubmed Data : Curr Vasc Pharmacol. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22022768

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View the Evidence: 110 Abstracts with Kidney Damage: Drug-Induced Research

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Cisplatin-associated severe acute kidney injury occurs in 20% of the patients and has a negative impact on long-term renal function and patient survival.Dec 31, 2014

Fenofibrates therapy is associated with deterioration of renal function.Jan 01, 2001

Fibrate-induced deterioration of renal function has been reported.Jan 01, 2009

High dose vitamin C significantly reduces the nephrotoxicity of vancomycin in critically ill patients.Mar 31, 2020

NSAID use has been associated with acute kidney failure. Mar 01, 2004

Prescribers should be aware of the potential adverse renal effects of chronic proton-pump inhibitors use.Apr 30, 2019

Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients.Sep 22, 2024

Proton pump inhibitors use is associated with a higher risk of incident chronic kidney disease.Dec 31, 2017

There is a dose-response relationship in statin-induced rhabdomyolysis.Mar 01, 2011

Zolendronic acid results in renal impairment in 23,8% of the prostate cancer patients it is administered to.Mar 15, 2007

A case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma has been reported.Jan 01, 2009

A case of NSAID-induced acute kidney injury has been reported. Jan 01, 1997

Simvastatin-induced rhabdomyolysis and acute renal injury has been reported.Jan 01, 2008

Terminal renal failure in lovastatin therapy with pre-existing chronic renal insufficiency has been reported.Jan 01, 1996

Varenicline-associated acute renal failure has been reported.Dec 01, 2008

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

Allicin and omega-3 fatty acids attenuates acetaminophen mediated renal toxicity.Jul 11, 2023

Ameliorate impacts of scopoletin against vancomycin-induced intoxication.Dec 31, 2021

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury.Jul 31, 2019

Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity.Mar 06, 2022

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Apocynin abrogates methotrexate-induced nephrotoxicity.Mar 31, 2023

Asiatic acid alleviates cisplatin-induced renal fibrosis in tumor-bearing mice.Aug 31, 2023

Astaxanthin prevented oxidative stress in the hearts and kidneys of Isoproterenol-administered aged rats.May 09, 2017

Astaxanthin prevents nephrotoxicity through Nrf2/ HO-1 pathway.Sep 07, 2023

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

Berberine was found to be an effective agent in the attenuation of diclofenac-induced acute kidney injury.Jul 31, 2019

Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity.Jan 31, 2023

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.Jan 01, 2005

Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.Sep 01, 2006

Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats.Aug 01, 2005

Curcumin prevents adriamycin nephrotoxicity in rats.Jan 01, 2000

Diallyl disulfide ameliorates methotrexate-induced nephropathy.Dec 31, 2020

Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration.Sep 30, 2023

Effects of rosmarinic acid on methotrexate-induced nephrotoxicity and hepatotoxicity.Apr 30, 2021

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Galangin provides significant protection against acetaminophen induced liver and kidney damage.Oct 31, 2015

Ginkgo biloba has a protective effect against uranium-induced liver and kidney damage in mice.Feb 01, 2010

Ginkgolide A downregulates transient receptor potential (melastatin) 2 to protect cisplatin-induced acute kidney injury.Dec 31, 2022

Glycyrrhizic acid improves tacrolimus-induced renal injury by regulating autophagy.Jan 31, 2023

Grape seed extract prevents gentamicin-induced nephrotoxicity and genotoxicity in bone marrow cells of mice.Sep 01, 2006

Grape seed extract protects against amiodarone - induced nephrotoxicity.Jan 10, 2021

Green tea has a protective effect against Ibuprofen induced glomerular atrophy in the kidney.Aug 31, 2018

Hepato and Nephro protective potentials of lyophilized juice of Citrus reticulata L. fruit against paracetamol induced toxicity in rats.Apr 30, 2024

Hesperidin and chrysin alleviated the renal injury induced by colistin via anti-oxidant and anti-inflammatory activities.Nov 30, 2018

High-intensity interval training ameliorates tramadol-induced nephrotoxicity and oxidative stress.May 31, 2024

Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.Feb 09, 2020

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.Aug 31, 2018

Kolaviron diminishes diclofenac-induced liver and kidney toxicity.Dec 31, 2019

Leaf extract of E. officinalis may ameliorate renal damage caused by cisplatin.Dec 31, 2017

Melatonin ameliorates the drug induced nephrotoxicity.Nov 13, 2019

Melatonin protects against tenofovir-induced nephrotoxicity.Nov 03, 2020

Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats.Apr 01, 2001

Moringa oleifera leaf extracts shielded kidneys from acetaminophen toxicity through enhancement of the endogenous antioxidant system.Dec 31, 2015

Naringenin ameliorates Cyclophosphamide-induced nephrotoxicity in experimental model.May 31, 2023

Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations.Nov 15, 2022

Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity.Dec 31, 2018

Nephroprotective effect of naringin in methotrexate induced renal toxicity.Sep 14, 2021

Nephroprotective effect of vitamin D against levofloxacin-induced renal injury.Jun 30, 2023

Nephroprotective property of Trifolium repens leaf extract against paracetamol-induced kidney damage.Nov 30, 2020

Nephrotoxicity and highly active antiretroviral therapy: Mitigating action of Momordica charantia.Dec 31, 2017

Nigella Sativa extract has shown protective effects on kidneys against aspirin-induced damage.Dec 31, 2020

Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.Sep 30, 2018

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Oleuropein attenuates the nephrotoxic effect of sunitinib.Apr 30, 2024

Paeonol protects against methotrexate-induced nephrotoxicity.Dec 31, 2021

Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity.Jun 03, 2022

Physiological and histopathological study on the influence of Ocimum basilicum leaves extract on thioacetamide-induced nephrotoxicity.Jun 30, 2020

Potential therapeutic efficacy of pachymic acid in chronic kidney disease.Jan 04, 2022

Kidney Damage: Drug-Induced

View the Evidence:
110 Abstracts with Kidney Damage: Drug-Induced Research