Kidney Fibrosis

Name	AC	CK
Astragaloside	4	8
Curcumin	4	8
Astaxanthin	3	6
Emodin	3	5
Pterostilbene	3	5
Asiatic Acid	2	4
Medicinal Mushrooms	2	4
Vitamin D	2	4
Cordyceps sinensis	2	3
Formononetin	1	3
Ginsenosides	2	3
Amygdalin	1	2
Arctigenin	1	2
Bee Venom	1	2
Berberine	1	2
Bisdemethoxycurcumin	1	2
Chlorogenic Acid	1	2
Fucoidan	1	2
Ginseng (Korean)	1	2
Gotu Kola	1	2
Grape Seed Extract	1	2
Hydrogen Water	1	2
Lactoferrin	1	2
Melatonin	2	2
Naringenin	1	2
Nigella sativa (aka Black Seed)	1	2
Paeonol	1	2
Perilla	1	2
Piceatannol	1	2
Puerarin	1	2
Resveratrol	1	2
Rhubarb	1	2
Rose	1	2
Silibinin	1	2
Tanshinone IIA	1	2
Thymoquinone	1	2
Traditional Chinese Medicine: Wen-pi-tang-Hab-Wu-ling-san	1	2
Tripterygium wilfordii	1	2
Triptolide	1	2
Zinc	1	2
Diosgenin	1	1
EGCG (Epigallocatechin gallate)	1	1
Fucoxanthin	1	1
Honokiol	1	1
Nicotinamide adenine dinucleotide (NADH)	1	1
Safflower	1	1
Salvia miltiorrhiza	1	1
Wogonin	1	1
Zhu Ling Mushroom	1	1

Name	AC	CK
Fructose	1	2
Gadolinium	1	2
Sodium Nitrate	1	2

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Fucoidan alleviates renal fibrosis in diabetic kidney disease.Dec 31, 2021

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Pubmed Data : Res Pharm Sci. 2017 Dec ;12(6):479-487. PMID: 29204176

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.Feb 18, 2019

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Pubmed Data : Mol Med Rep. 2019 Feb 19. Epub 2019 Feb 19. PMID: 30816496

Article Published Date : Feb 18, 2019

Study Type : Animal Study

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Substances : Astaxanthin

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

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Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.Apr 04, 2018

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Pubmed Data : Mar Drugs. 2018 Apr 5 ;16(4). Epub 2018 Apr 5. PMID: 29621130

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

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Pubmed Data : Am J Transl Res. 2015 ;7(5):932-40. Epub 2015 May 15. PMID: 26175854

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Cordyceps sinensis

Diseases : Kidney Fibrosis

Pharmacological Actions : Renoprotective

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Calcitriol ameliorates kidney injury through reducing podocytopathy, tubular injury, inflammation and fibrosis.Mar 26, 2020

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Pubmed Data : J Zhejiang Univ Sci B. 2011 Dec ;12(12):1024-33. PMID: 22135152

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Pubmed Data : Biochem Biophys Res Commun. 2021 Jan 1 ;534:279-285. Epub 2020 Dec 4. PMID: 33288199

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Emodin

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

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Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis.Jul 31, 2021

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Ginsenoside-Rg1 protects against renal fibrosis. Dec 31, 2017

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Pubmed Data : Eur J Pharmacol. 2019 Jan 5 ;842:70-78. Epub 2018 Oct 16. PMID: 30336139

Article Published Date : Jan 04, 2019

Study Type : Animal Study

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Substances : Pterostilbene

Diseases : High Fructose Diet, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

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Pterostilbene alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:4946580. Epub 2019 Aug 20. PMID: 31531112

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Rose

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective

Additional Keywords : Plant Extracts

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Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway.Jan 17, 2020

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Pubmed Data : Hum Cell. 2020 Jan 18. Epub 2020 Jan 18. PMID: 31953678

Article Published Date : Jan 17, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Silibinin

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic

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Sulforaphane protects against diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7.Jun 03, 2021

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Pubmed Data : Diabetes Metab J. 2021 Jun 4. Epub 2021 Jun 4. PMID: 34082508

Article Published Date : Jun 03, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Sulforaphane

Diseases : Diabetic Nephropathy, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

Additional Keywords : Epigenetic Modification

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The flavonoid fisetin ameliorates renal fibrosis.Apr 30, 2023

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Pubmed Data : Ther Adv Chronic Dis. 2019 ;10:2040622319869116. Epub 2019 Aug 14. PMID: 31452866

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Melatonin

Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

Additional Keywords : Polysaccharides

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Cordyceps Sinensis inhibits the epithelial-mesenchymal transition and protects against renal fibrosis in diabetic nephropathy.Nov 13, 2019

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Pubmed Data : Carbohydr Polym. 2022 Jan 15 ;276:118772. Epub 2021 Oct 18. PMID: 34823789

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Pubmed Data : Int J Environ Res Public Health. 2022 02 7 ;19(3). Epub 2022 Feb 7. PMID: 35162887

Article Published Date : Jan 06, 2022

Study Type : Review

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Substances : Mangiferin

Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis, Oxidative Stress

Pharmacological Actions : Renoprotective

Additional Keywords : Plant Extracts, Xanthones

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Renoprotective effects of tanshinone IIA: A literature review. Feb 19, 2023

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Pubmed Data : Molecules. 2023 Feb 20 ;28(4). Epub 2023 Feb 20. PMID: 36838978

Article Published Date : Feb 19, 2023

Study Type : Review

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Substances : Tanshinone IIA

Diseases : Acetaminophen (Tylenol) Toxicity , Diabetic Nephropathy, Kidney Cancer, Kidney Damage, Kidney Fibrosis

Pharmacological Actions : Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen

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Pubmed Data : Front Pharmacol. 2022 ;13:919967. Epub 2022 Aug 29. PMID: 36105187

Article Published Date : Dec 31, 2021

Study Type : Review

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Substances : Rhubarb

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Renoprotective

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Wogonin ameliorates renal inflammation and fibrosis in diabetic nephropathy.Dec 31, 2019

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Pubmed Data : Drug Des Devel Ther. 2020 ;14:4135-4148. Epub 2020 Oct 8. PMID: 33116403

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Diabetic Nephropathy, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor

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β-elemene attenuates renal fibrosis in the unilateral ureteral obstruction model.May 15, 2022

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Pubmed Data : Int J Mol Sci. 2022 May 16 ;23(10). Epub 2022 May 16. PMID: 35628363

Article Published Date : May 15, 2022

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective, STAT3 Inhibitor

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View the Evidence: 114 Abstracts with Kidney Fibrosis Research

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Fucoidan alleviates renal fibrosis in diabetic kidney disease.Dec 31, 2021

Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway.Apr 14, 2022

Tanshinone IIA improves diabetes-induced renal fibrosis.Oct 31, 2022

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.Nov 30, 2017

Amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.Apr 30, 2013

Analysis of the potential biological mechanisms of diosmin against renal fibrosis.May 12, 2023

Andrographolide prevents high glucose-induced renal tubular cell damage.Jul 08, 2021

Arctigenin could protect the kidney from unilateral ureteral obstruction induced injury and fibrogenesis.Jun 30, 2017

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.Feb 18, 2019

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.Apr 04, 2018

Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.Jun 02, 2019

Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition.Dec 31, 2018

Astragaloside IV improves renal function and fibrosis.Dec 31, 2017

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy.Sep 30, 2019

Bee venom may be a useful therapeutic agent for the prevention of fibrosis that characterizes progression of chronic kidney disease.May 31, 2015

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Bisdemethoxycurcumin protects against renal fibrosis.Mar 14, 2019

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney.Dec 31, 2020

Bixin can be exploited therapeutically to alleviate renal interstitial fibrosis by targeting STAT6 signaling deactivation.Dec 31, 2019

C. sinensis may be a promising agent to combat renal fibrosis.Dec 31, 2014

Calcitriol ameliorates kidney injury through reducing podocytopathy, tubular injury, inflammation and fibrosis.Mar 26, 2020

Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.May 31, 2022

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis.Jan 10, 2020

Carvacrol preserves antioxidant status and attenuates kidney fibrosis.Oct 16, 2022

Centella asiatica extract attenuates kidney fibrosis.Dec 31, 2020

Chlorogenic acid attenuates kidney ischemic/reperfusion injury.Dec 31, 2018

Chrysin ameliorates cyclosporine-A-induced renal fibrosis.Sep 22, 2021

Coenzyme Q10 attenuates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation.Jun 30, 2022

Cordyceps cicadae ameliorates renal hypertensive injury and fibrosis.Dec 31, 2020

Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model.Nov 30, 2011

Curcumin attenuates renal fibrosis in rat obstructive nephropathy.Feb 01, 2006

Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis.Nov 01, 2005

Curcumin might be an effective antifibrotic drug in the treatment of chronic kidney disease.Jul 01, 2004

Emodin ameliorates renal damage and podocyte injury in a model of diabetic nephropathy.Dec 31, 2020

Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.Dec 31, 2020

Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis.Jul 31, 2021

Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis.May 23, 2023

Formononetin activates the Nrf2/ARE signaling pathway Via Sirt1 to improve diabetic renal fibrosis.Dec 31, 2019

Fructose-fed rats exhibit increased inflammation, fibrogenesis and NF-κB activation.Jun 17, 2011

Fucoidans from Cucumaria frondosa ameliorate renal interstitial fibrosis via inhibition of the PI3K/Akt/NF-κB signaling pathway.Feb 06, 2022

Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis.Nov 11, 2021

Gadolinium-based contrast agents: Stimulators of myeloid-induced renal fibrosis and major metabolic disruptors.Jul 14, 2019

Gastrodin attenuates carbon tetrachloride-induced kidney inflammation and fibrosis.Apr 30, 2020

Ginsenoside Rb1 ameliorated bavachin-induced renal fibrosis. Dec 31, 2021

Ginsenoside Rg1 treatment alleviates renal fibrosis.Nov 30, 2023

Ginsenoside-Rg1 protects against renal fibrosis. Dec 31, 2017

GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.Dec 20, 2019

Hydrogen water can inhibit the development of fibrosis in kidney.Dec 31, 2016

Ketogenic diet alleviates renal fibrosis.Dec 31, 2022

Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis.May 22, 2020

Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis.May 07, 2020

Low molecular weight fucoidan can inhibit the fibrosis of diabetic kidneys by regulating the kidney lipid metabolism.Dec 31, 2020

Metabolomics reveals the renoprotective effect of n-butanol extract and amygdalin extract from Amygdalus mongolica in rats with renal fibrosis.Nov 30, 2021

Nigella sativa oil ameliorates sodium nitrite-induced nephrotoxicity in animals. Jul 28, 2015

Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes.Dec 14, 2022

Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis.Dec 31, 2018

Nrf2 knockout attenuates the astragaloside IV therapeutic effect on kidney fibrosis from liver cancer by regulating pSmad3C/3L pathways.Sep 14, 2023

Oligo-fucoidan improves diabetes-induced renal fibrosis. Oct 07, 2020

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats.Jul 04, 2023

Perilla frutescens sprout extract may be useful for the prevention or treatment of diabetic nephropathy.Feb 07, 2019

Piceatannol may be a beneficial therapeutic agent for treating renal fibrosis.Dec 31, 2015

Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6.Sep 14, 2023

Polyporus umbellatus protects against renal fibrosis.Dec 31, 2020

Pterostilbene alleviates fructose-induced renal fibrosis.Jan 04, 2019

Pterostilbene alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.Dec 31, 2018

Puerarin attenuates renal fibrosis by reducing oxidative stress.Oct 31, 2017

Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

Resveratrol is a potential therapeutic agent for preventing renal fibrosis.Aug 26, 2019

Rosa roxburghii fruit freeze-dried powder could effectively prevent renal fibrosis and injury.Dec 31, 2018

Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway.Jan 17, 2020

Kidney Fibrosis

View the Evidence:
114 Abstracts with Kidney Fibrosis Research