Leiomyoma

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31 Substances Researched for Leiomyoma
NameACCKFocus
Vitamin D537Locked
Genistein414Locked
Green Tea212Locked
Cruciferous Vegetables110Locked
Daidzein110Locked
Enterodiol110Locked
Enterolactone110Locked
Equol110Locked
Fruit: All110Locked
Isoflavones110Locked
Lignans110Locked
EGCG (Epigallocatechin gallate)37Locked
Anthocyanins15Locked
Strawberry15Locked
Curcumin22Locked
Euonymus alatus (Burning Bush)12Locked
Licorice12Locked
Lycopene12Locked
Progesterone12Locked
Puerarin12Locked
Rosemary12Locked
Sculletaria barbata12Locked
Adlay11Locked
Artichoke11Locked
Curcumol11Locked
Fisetin11Locked
Fucoidan11Locked
Hops11Locked
Isoliquiritigenin11Locked
Melatonin11Locked
Resveratrol11Locked
5 Problem Substances Researched for Leiomyoma
NameACCKFocus
Phthalates230Locked
Talc110Locked
Bisphenol A 34Locked
17beta-estradiol11Locked
Parabens11Locked
1 Therapeutic Actions Researched for Leiomyoma
NameACCKFocus
Dietary Modification: Vegetarian110Locked

View the Evidence:
37 Abstracts with Leiomyoma Research

[+]

Phthalate exposure as a hidden risk factor for uterine leiomyoma in adult women.Sep 17, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2024 Sep 18 ;285:117069. Epub 2024 Sep 18. PMID: 39299212
Article Published Date : Sep 17, 2024
Study Type : Meta Analysis
Additional Links
Diseases : Leiomyoma, Phthalate Toxicity
Problem Substances : Phthalates
[+]

A greater intake of fresh fruits and cruciferous vegetables may be able to reduce the incidence of uterine fibroids.Oct 11, 2015

Pubmed Data : J Obstet Gynaecol Res. 2015 Oct 12. Epub 2015 Oct 12. PMID: 26458740
Article Published Date : Oct 11, 2015
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Fruit: All
Diseases : Fibroids: Uterine
Therapeutic Actions : Dietary Modification: Vegetarian
Additional Keywords : Risk Reduction
[+]

Association of genital talc and douche use in early adolescence or adulthood with uterine fibroids diagnoses.Nov 30, 2023

Pubmed Data : Am J Obstet Gynecol. 2023 Dec ;229(6):665.e1-665.e10. Epub 2023 Aug 18. PMID: 37598998
Article Published Date : Nov 30, 2023
Study Type : Human Study
Additional Links
Diseases : Fibroids: Uterine
Problem Substances : Talc
[+]

Phthalate exposures and MicroRNA expression in uterine fibroids.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epigenet Insights. 2020 ;13:2516865720904057. Epub 2020 Feb 18. PMID: 32128507
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Fibroids: Uterine, Phthalate Toxicity
Problem Substances : Phthalates
[+]

The concomitant administration of vitamin D and EGCG represents a promising treatment of uterine fibroids in women.Oct 15, 2021

Pubmed Data : Gynecol Endocrinol. 2021 Oct 16:1-5. Epub 2021 Oct 16. PMID: 34658291
Article Published Date : Oct 15, 2021
Study Type : Human Study
Additional Links
Substances : Green Tea, Vitamin D
Diseases : Fibroids: Uterine
[+]

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Daidzein, Enterodiol, Enterolactone, Equol, Genistein, Isoflavones, Lignans
Diseases : Fibroids: Uterine
[+]

Vitamin D appears to be a promising and safe agent in the prevention of recurrence and reduction of the size of recurrent uterine fibroids.Jan 23, 2022

Pubmed Data : Complement Ther Clin Pract. 2022 Jan 24 ;46:101536. Epub 2022 Jan 24. PMID: 35092948
Article Published Date : Jan 23, 2022
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Fibroids: Uterine
Additional Keywords : Risk Reduction
[+]

Vitamin D supplementation seems to reduce the progression of uterine fibroids to an extensive disease.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2016 Dec ;95(52):e5698. PMID: 28033263
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Fibroids: Uterine, Vitamin D Deficiency
[+]

Strawberry can be developed as therapeutic or preventive agent for uterine leiomyomas.Feb 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28212568
Article Published Date : Feb 14, 2017
Study Type : Human In Vitro
Additional Links
Substances : Anthocyanins, Strawberry
Diseases : Leiomyoma
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

A case report of spontaneous complete regression of large uterine fibroid after the second vaginal delivery.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2018 Nov ;97(45):e13092. PMID: 30407315
Article Published Date : Oct 31, 2018
Study Type : Human: Case Report
Additional Links
Diseases : Fibroids: Uterine
Additional Keywords : Spontaneous Regression
[+]

EGCG inhibits fibroid tumors in quail. Feb 01, 2008

Pubmed Data : Nutr Res. 2008 Feb;28(2):92-7. PMID: 19083394
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice.Jan 12, 2010

Pubmed Data : Am J Obstet Gynecol. 2010 Jan 12. Epub 2010 Jan 12. PMID: 20074693
Article Published Date : Jan 12, 2010
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Lycopene supplementation reduces the size of spontaneously occuring leiomyoma in quail, indicating that it may have therapeutic value in the treatment of uterine leiomyoma in humans. Jan 01, 2004

Pubmed Data : Nutr Cancer. 2004;50(2):181-9. PMID: 15623465
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Leiomyoma
[+]

Puerarin had an improvement effect on ischemia-reperfusion injury-induced uterine fibrosis.Jul 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2017 Jul 13 ;23:3404-3411. Epub 2017 Jul 13. PMID: 28704345
Article Published Date : Jul 12, 2017
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Fibroids: Uterine, Ischemia
Pharmacological Actions : Anti-Fibrotic
[+]

Rosemary leaves enhance the metabolism of endogenous estrogens and decreases their uterotropic effect in mice. Oct 01, 1998

Pubmed Data : Carcinogenesis. 1998 Oct;19(10):1821-7. PMID: 9806165
Article Published Date : Oct 01, 1998
Study Type : Animal Study
Additional Links
Substances : Rosemary
Diseases : Endometrial Cancer, Estrogen Dominance, Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios, Fibroids: Uterine, Uterine Cancer
Additional Keywords : Plant Extracts
[+]

These results support a role of BPA in uterine leiomyoma development and growth.Mar 31, 2016

Pubmed Data : Reprod Sci. 2016 Apr ;23(4):508-14. Epub 2015 Oct 6. PMID: 26445998
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Leiomyoma
Additional Keywords : Risk Factors
Problem Substances : Bisphenol A
[+]

A flavonoid found within Licorice inhibits cell proliferation in human uterine leiomyoma (fibroid) cells and increases cell arrest. Jul 01, 2008

Pubmed Data : Reprod Sci. 2008 Jul;15(6):552-8. Epub 2008 May 16. PMID: 18487228
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
[+]

Adlay hull extract fraction could be considered as a natural plant-based medicine in the prevention or treatment of uterine leiomyoma growth.Apr 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 19 ;24(8). Epub 2019 Apr 19. PMID: 31010220
Article Published Date : Apr 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Bisphenol A induces human uterine leiomyoma cell proliferation.Jan 03, 2019

Pubmed Data : Mol Cell Endocrinol. 2019 Jan 4. Epub 2019 Jan 4. PMID: 30615907
Article Published Date : Jan 03, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity, Leiomyoma
Additional Keywords : Increased Risk
Problem Substances : Bisphenol A
[+]

Bisphenol A, 17beta-estradiol, and Parabens increase rat uterine weights. May 01, 2005

Pubmed Data : Environ Res. 2005 May;98(1):40-5. PMID: 15721882
Article Published Date : May 01, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Fibroids: Uterine, Uterine Cancer
Additional Keywords : Sunscreen
Problem Substances : 17beta-estradiol, Bisphenol A , Parabens
[+]

Curcumin inhibits leiomyoma (fibroid) cell proliferation and fibronection expression. May 01, 2009

Pubmed Data : Fertil Steril. 2009 May;91(5 Suppl):2177-84. Epub 2008 Jun 13. PMID: 18555241
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Fibroid Tumor, Leiomyoma
[+]

Curcumin inhibits uterine leiomyoma cell proliferation.Jul 30, 2010

Pubmed Data : Gynecol Endocrinol. 2010 Jul 30. Epub 2010 Jul 30. PMID: 20672906
Article Published Date : Jul 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leiomyoma
Pharmacological Actions : Anti-Proliferative
[+]

Curcumol attenuates human uterine leiomyoma cell development.Jun 27, 2023

Pubmed Data : J Ethnopharmacol. 2023 Jun 28 ;310:116311. Epub 2023 Mar 7. PMID: 36894110
Article Published Date : Jun 27, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
[+]

Euonymus alatus inhibits human uterine leiomyomal (fibroid) smooth muscle cells. Mar 01, 2006

Pubmed Data : Int J Gynecol Cancer. 2006 Mar-Apr;16(2):843-8. PMID: 16681771
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Euonymus alatus (Burning Bush)
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
[+]

Fucoidan displays anti-proliferation and anti-fibrotic effects and exerts protective effects against uterine leiomyomas development.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;49(5):1970-1986. Epub 2018 Sep 20. PMID: 30235439
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Genistein may have value in uterine fibroids. Jan 06, 2012

Pubmed Data : Exp Mol Med. 2012 Jan 6. Epub 2012 Jan 6. PMID: 22228119
Article Published Date : Jan 06, 2012
Study Type : Commentary
Additional Links
Substances : Genistein
Diseases : Fibroids: Uterine
[+]

Genistein suppresses estradiol-induced uterine leiomyoma cell proliferation.Dec 31, 2004

Pubmed Data : Life Sci. 2004 Dec 31;76(7):775-82. PMID: 19903033
Article Published Date : Dec 31, 2004
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Estrogen Dominance, Leiomyoma
[+]

Genistein's inhibitory effect on leiomyoma (fibroids) cell proliferation are dependant on concentration. Oct 01, 2007

Pubmed Data : Hum Reprod. 2007 Oct;22(10):2623-31. Epub 2007 Aug 27. PMID: 17725991
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
[+]

Hop and artichoke extracts inhibit expression of extracellular matrix components in uterine leiomyoma cells.Oct 31, 2021

Pubmed Data : F S Sci. 2021 Nov ;2(4):407-418. Epub 2021 Oct 26. PMID: 35559863
Article Published Date : Oct 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Artichoke, Hops
Diseases : Leiomyoma
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Plant Extracts
[+]

Isoliquiritigenin suppresses E2-induced uterine leiomyoma growth.Aug 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2019 Aug 7 ;11(8). Epub 2019 Aug 7. PMID: 31394829
Article Published Date : Aug 06, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
[+]

melatonin potentially plays a role in suppression of uterine leiomyoma growth.Dec 31, 2019

Pubmed Data : J Pineal Res. 2020 Jan ;68(1):e12620. Epub 2019 Nov 28. PMID: 31710386
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Progesterone inhibits IGF-1 expression in human uterine leiomyoma (fibroid) cells. Apr 01, 2004

Pubmed Data : Hum Reprod. 2004 Apr;19(4):815-21. Epub 2004 Jan 29. PMID: 15033949
Article Published Date : Apr 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Progesterone
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
[+]

Resveratrol can be considered an alternative therapeutic agent for myomas.Jul 16, 2018

Pubmed Data : Food Chem Toxicol. 2018 Jul 17 ;120:346-355. Epub 2018 Jul 17. PMID: 30026090
Article Published Date : Jul 16, 2018
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative
[+]

Scutellaria barbata reduces the over-expression of Bcl-2 protein. May 01, 2008

Pubmed Data : Phytother Res. 2008 May;22(5):583-90. PMID: 18444248
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sculletaria barbata
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma
[+]

Synthesized prodrugs of EGCG analogs have potent antiproliferative, antiangiogenic and antifibrotic activities.Mar 06, 2016

Pubmed Data : J Cell Biochem. 2016 Mar 7. Epub 2016 Mar 7. PMID: 26950525
Article Published Date : Mar 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Leiomyoma
Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Antiproliferative
[+]

These findings suggest that fisetin may be used for the prevention and treatment of uterine leiomyomas.May 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 May 14 ;10(1):7993. Epub 2020 May 14. PMID: 32409692
Article Published Date : May 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Leiomyoma
Pharmacological Actions : Apoptotic
[+]

Vitamin D inhibits leiomyoma (fibroid) cell growth, in vitro. May 01, 2009

Pubmed Data : Fertil Steril. 2009 May;91(5):1919-25. Epub 2008 Apr 18. PMID: 18423458
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Fibroid Tumor, Fibroids: Uterine, Leiomyoma

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