Leishmaniasis

Name	AC	CK
Nigella sativa (aka Black Seed)	3	13
Noni	2	11
Bee Propolis	4	7
Curcumin	7	7
Flavonoids	6	7
Syrian rue	4	7
Homeopathic Medicine: All	3	5
Lupeol	3	5
Achiote	2	4
Allicin	2	4
Apigenin	3	4
Ashwagandha	2	4
Berberine	3	4
Holy Basil	2	4
Piperine	3	4
Carvacrol	2	3
Coconut	2	3
Elderberry	2	3
Feverfew	2	3
Pomegranate	2	3
Quercetin	3	3
Thymoquinone	3	3
Artemisinin	2	2
Beta Sitosterol	1	2
Black Pepper	1	2
Boerhaavia diffusa	1	2
Cinnamaldehyde	2	2
Cinnamon	2	2
Crocin	2	2
Emodin	1	2
Garlic	2	2
Gingerol	1	2
Gold (nanoparticles)	1	2
Kaempferol	1	2
Oak	1	2
Royal Jelly	2	2
Saffron	2	2
Sea Cucumber	1	2
Thyme	1	2
Thymol	1	2
Turmeric	2	2
Verbascoside	2	2
Yarrow	1	2
Aloe Vera	1	1
Andrographolide	1	1
Banana	1	1
Betulinic acid	1	1
Calophyllum brasiliense	1	1
Camu Camu	1	1
Cannabinoids	1	1
Cannabis	1	1
Carpolobia lutea	1	1
Chamomile	1	1
Cholesterol	1	1
Coconut Husk/Fiber	1	1
Curcuminoids	1	1
Dill	1	1
Eugenol	1	1
Fisetin	1	1
Frankincense	1	1
Fucoidan	1	1
Goldenrod	1	1
Green Tea	1	1
Guava	1	1
Harmine	1	1
Henna	1	1
Hesperidin	1	1
Jambul	1	1
Licorice	1	1
Luteolin	1	1
Marjoram	1	1
Moringa oleifera	1	1
Mululuza	1	1
Myrtle (Myrtus communis L.)	1	1
Nettle	1	1
Olive leaf extract	1	1
Onion	1	1
Orange	1	1
Oregano	1	1
Parthenolide	1	1
Piceatannol	1	1
Piperidines	1	1
Piperlongumine	1	1
Pistachio nut	1	1
Plum	1	1
Polyphenols	1	1
Psychedelics:All	1	1
Resveratrol	1	1
Rutin	1	1
Safranal	1	1
Sesamol	1	1
Silver (nanoparticles)	1	1
Stevia	1	1
Stigmasterol	1	1
Turmerones	1	1
Ursolic Acid	1	1
White Clover	1	1
Xanthohumol	1	1
Xylitol	1	1
Zataria multiflora	1	1
Zerumbone	1	1

Name	AC	CK
Photobiomodulation	1	10
Exercise	1	2
Light Therapy: Red Colored	1	2

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In this study of 40 patients 50% of them showed an excellent response and 30% exhibited good improvement to the treatment..Jan 31, 2012

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Pubmed Data : Nat Prod Commun. 2012 Feb ;7(2):195-6. PMID: 22474954

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Pubmed Data : Int J Environ Res Public Health. 2017 Jul 13 ;14(7). Epub 2017 Jul 13. PMID: 28703780

Article Published Date : Jul 12, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Allicin

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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Allicin has antileishmanial effects under in vitro and in vivo conditions and may be used in clinical applications.Dec 31, 2015

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Pubmed Data : Parasitol Res. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26711452

Article Published Date : Dec 27, 2015

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Leishmaniasis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

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Feverfew extracts represents a promising alternative for the treatment of leishmaniasis.Jul 31, 2014

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Pubmed Data : Exp Parasitol. 2014 Aug ;143:18-23. Epub 2014 May 5. PMID: 24810433

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Pubmed Data : Parasitology. 2019 Sep ;146(11):1440-1450. Epub 2019 Jun 13. PMID: 31104636

Article Published Date : Aug 31, 2019

Study Type : Animal Study

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Substances : Lupeol

Diseases : Leishmaniasis

Pharmacological Actions : Antiparasitic Agents, Immunomodulatory

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Moderate intensity exercise is able to modulate the Th1 response that provides a protective effect against the development of leishmanial lesions.Dec 31, 2018

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Pubmed Data : J Antimicrob Chemother. 2011 Mar ;66(3):618-25. Epub 2011 Jan 14. PMID: 21393231

Article Published Date : Feb 28, 2011

Study Type : Viral

Additional Links

Substances : Fucoidan

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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"Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol."Oct 09, 2012

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Pubmed Data : J Lipid Res. 2012 Oct 10. Epub 2012 Oct 10. PMID: 23060454

Article Published Date : Oct 09, 2012

Study Type : Review

Additional Links

Substances : Cholesterol

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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A hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation could represent good strategy for the development of new antileishmanial agent.Dec 31, 2013

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Pubmed Data : Biomed Res Int. 2014 ;2014:694934. Epub 2014 Jun 18. PMID: 25045693

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Pubmed Data : Phytother Res. 2008 Apr ;22(4):455-7. PMID: 18167046

Article Published Date : Mar 31, 2008

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

Additional Keywords : Plant Extracts

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Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasisDec 31, 2019

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Pubmed Data : Planta Med. 2011 May ;77(7):749-53. Epub 2010 Dec 2. PMID: 21128202

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Jun 15 ;26(12). Epub 2021 Jun 15. PMID: 34203815

Article Published Date : Jun 14, 2021

Study Type : In Vitro Study

Additional Links

Substances : Frankincense

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

Additional Keywords : Plant Extracts

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Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.Apr 05, 2020

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Pubmed Data : Eur J Pharm Sci. 2020 Apr 6:105335. Epub 2020 Apr 6. PMID: 32272211

Article Published Date : Apr 05, 2020

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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Characterization of Antileishmanial Compounds from Lawsonia inermis L. Leaves.Dec 31, 2016

Flavonoids from Pistacia chinensis subsp. integerrima with leishmanicidal activity: computational and experimental evidence.Jun 25, 2023

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Insecticidal, antimalarial, and antileishmanial effects of royal jelly.Dec 31, 2021

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Pubmed Data : J Ethnopharmacol. 2015 Feb 3 ;160:32-40. Epub 2014 Nov 25. PMID: 25460590

Article Published Date : Feb 02, 2015

Study Type : In Vitro Study

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Substances : Jambul

Diseases : Leishmaniasis

Pharmacological Actions : Antiproliferative , Immunomodulatory, Leishmanicidal

Additional Keywords : Essential Oils

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The aim of this work is to collate all available published scientific reports in the literature on Carpolobia.Jun 30, 2015

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Pubmed Data : Pharmacogn Rev. 2015 Jul-Dec;9(18):132-9. PMID: 26392711

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Pubmed Data : IET Nanobiotechnol. 2018 Dec ;12(8):1018-1026. PMID: 30964007

Article Published Date : Nov 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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The results presented here highlight C. sinensis as a promising source of antileishmanial agents.Nov 30, 2017

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Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1780-1786. PMID: 28524774

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Pubmed Data : Korean J Parasitol. 2015 Feb ;53(1):21-7. Epub 2015 Feb 27. PMID: 25748705

Article Published Date : Jan 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Myrtle (Myrtus communis L.)

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

Additional Keywords : Dose Response, Essential Oils, Plant Extracts

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This study indicates that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.Feb 28, 2014

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Pubmed Data : Z Naturforsch C. 2014 Mar-Apr;69(3-4):110-6. PMID: 24873031

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Pubmed Data : Neurosci Lett. 1999 Apr 2;264(1-3):141-4. PMID: 10865470

Article Published Date : Apr 02, 1999

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Leishmaniasis, Malaria

Pharmacological Actions : Antimalarials, Leishmanicidal

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Ursolic acid is an interesting natural compound that should be considered for the development of prototype drugs against visceral leishmaniasis.Mar 31, 2017

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Pubmed Data : Int J Parasitol Drugs Drug Resist. 2017 Apr ;7(1):1-11. Epub 2016 Dec 8. PMID: 27984757

Article Published Date : Mar 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

[+]

[+]

Zerumbone has potential therapeutic use against L. donovani infection.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Braz J Infect Dis. 2016 Jan-Feb;20(1):48-55. Epub 2015 Nov 28. PMID: 26643969

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Zerumbone

Diseases : Leishmaniasis, Oxidative Stress

Pharmacological Actions : Antiparasitic Agents

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View the Evidence: 126 Abstracts with Leishmaniasis Research

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In this study of 40 patients 50% of them showed an excellent response and 30% exhibited good improvement to the treatment..Jan 31, 2012

Low-level laser therapy for the treatment of early stage cutaneous leishmaniasis.Aug 26, 2020

Novel insight into potential leishmanicidal activities of transdermal patches of Nigella sativa.Jun 27, 2021

A methanol soluble extract of sea cucumber exhibited excellent anti-leishmanial activity.Jul 01, 2008

Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana Jun 25, 2021

Allicin could be promising for the treatment of human cutaneous leishmaniasis and the control of secondary bacterial infections.Jul 12, 2017

Allicin has antileishmanial effects under in vitro and in vivo conditions and may be used in clinical applications.Dec 31, 2015

aloe-emodin showed antileishmanial effects under in vitro and in vivo conditions and may be used in clinical trials. Mar 31, 2015

An ethanol extract of P. harmala is efficient in the treatment of cutaneous leishmaniasis and is comparable with that of Glucantime.Jun 30, 2014

Apigenin exhibits leishmanicidal effects against L. amazonensis-infected macrophages. Jan 31, 2016

B. orellana extract showed a significant activity against promastigote and amastigote forms of L. amazonensis.Dec 31, 2010

Berberine-loaded liposomes for the treatment of Leishmania infantum.Sep 08, 2020

Coconut and holy basil rescued the affected mice from the disease.Feb 28, 2017

Combination of infra-red light with nanogold targeting macrophages in the treatment of Leishmania major.Feb 28, 2022

Daily low doses of Brazilian propolis reduced the secondary chronic inflammatory process in the liver caused by L. amazonensis subcutaneous infection.Dec 27, 2015

Feverfew extracts represents a promising alternative for the treatment of leishmaniasis.Jul 31, 2014

Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum.Jun 30, 2017

Lupeol and amphotericin B mediate synergistic anti-leishmanial immunomodulatory effects.Dec 31, 2020

Lupeol induces immunity and protective efficacy in a murine model against visceral leishmaniasis.Aug 31, 2019

Moderate intensity exercise is able to modulate the Th1 response that provides a protective effect against the development of leishmanial lesions.Dec 31, 2018

Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines.Sep 30, 2014

P harmala seeds extract showed significant in vitro and in vivo antileishmanial activities. Jul 31, 2011

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Peganum harmala and Nigella sativa: anti-leishmanial activity against Leishmania major.Dec 31, 2020

Pomegranate juice shows antioxidant activity against cutaneous leishmaniasis-induced oxidative stress.Dec 17, 2017

S. ebulus extract may be a perfect therapeutic option for cutaneous leishmaniasis treatment.Dec 31, 2018

The ability of Bixa oil to control disease progression of established cutaneous leishmaniasis in mice was demonstrated.Apr 30, 2014

The comparative study of the efficacy of β-sitosterol, ketoconazole 2% and mupirocin for the treatment cutaneous leishmaniosis.Dec 31, 2021

The present study showed potent antileishmanial and antioxidant activity of oak extract.Jul 31, 2016

Therapeutic potentials of 6-gingerol in combination with amphotericin B for treatment of Leishmania major infection.Nov 30, 2021

These findings suggest a new option for antileishmanial chemotherapy at lower cost and nil toxicity.Jul 31, 2015

These result concludes that withanolides in alcoholic fractions demonstrate a potent antileishmanial and immunomodulatory activities.Dec 31, 2016

Thyme, yarrow and propolis are significantly more effective than glucantime in the treatment of Leishmaniasis in mice. Jan 01, 2008

Thymol and carvacrol are highly promising candidates for the development of effective and safe drugs in the fight against visceral leishmaniasis.May 29, 2019

Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs.Jan 14, 2017

"Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants."Feb 28, 2011

"Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol."Oct 09, 2012

A hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation could represent good strategy for the development of new antileishmanial agent.Dec 31, 2013

A systematic review of curcumin and its derivatives as valuable sources of antileishmanial agents.Mar 25, 2021

Aloe vera leaf extract has leishmanial activity. May 01, 2007

Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations.Dec 08, 2010

Anti-candida and anti-leishmanial activities of encapsulated cinnamomum verum essential oil.Jul 26, 2023

Anti-leishmanial effects of a novel biocompatible non-invasive nanofibers containing royal jelly and propolis against Iranian strain of Leishmania major.Nov 30, 2023

Anti-parasitic activities of Allium sativum and Allium cepa against Trypanosoma b. brucei and Leishmania tarentolae.Apr 20, 2018

Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds.Mar 31, 2008

Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasisDec 31, 2019

Antileishmanial activity of verbascoside.Dec 31, 2016

Antileishmanial and immunomodulatory activities of lupeol.Sep 30, 2017

Antileishmanial germacranolides from Calea zacatechichi.Apr 30, 2011

Antiparasitic effect of the Psidium guajava and Psidium brownianum.Mar 12, 2018

Antiproliferative properties of Turmerone on Leishmania major.Apr 30, 2022

Antiprotozoal activity of thymoquinone for the treatment of Leishmania major.Sep 05, 2022

Antiprotozoal activity of Turkish Origanum onites essential oil and its components. Dec 02, 2019

Apigenin effect against Leishmania tropica amastigotes in vitro.Aug 31, 2020

Apigenin is a promising molecule for treatment of visceral leishmaniasis.Dec 31, 2022

Artemisinin and its derivatives may be good alternatives for treating other non-malarial protozoan infections.Nov 16, 2016

Artemisinin triggers induction of cell-cycle arrest and programmed cell death in Leishmania donovani promastigotes.Sep 01, 2007

Baccharis dracunculifolia compounds exhibit antileishmanial, antiplasmodial and cytotoxic activities.Dec 01, 2009

Banana contains compounds which when metabolically transformed by fungi have leishmanicidal activity. May 01, 2004

Berberine chloride causes programmed cell death in Leishmania donovani promastigotes. Aug 07, 2009

Biologically active cannabinoids from high-potency Cannabis sativa displayed significant antibacterial and antifungal activities.May 21, 2009

Boswellic acids show in vitro activity against Leishmania donovani.Jun 14, 2021

Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.Apr 05, 2020

Characterization of Antileishmanial Compounds from Lawsonia inermis L. Leaves.Dec 31, 2016

Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils: chemical composition, antimicrobial and antileishmanial activity.Dec 31, 2018

Coconut husk fiber contains compounds with significant leishmanicidal activity. Apr 01, 2004

Comparison of the effects of Sambucus ebulus leaf and fruit extracts on Leishmania major.Dec 31, 2020

Coumarins from Calophyllum brasiliense displayed in vitro activity against amastigote forms of Trypanosoma cruzi and Leishmania infantum.Nov 30, 2021

Curcumin has anti-Leishmanial activity. Apr 01, 2005

Curcumin has leischmaniacidal activity in vitro. Mar 01, 2002

Curcumin has leishmanicidal activity. Jan 01, 2002

Curcumin induces programmed cell death in Leishmania through its pro-oxidant and calcium-modulating activity. Jul 01, 2008

Leishmaniasis

View the Evidence:
126 Abstracts with Leishmaniasis Research