Leishmaniasis

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81 Substances Researched for Leishmaniasis
NameACCKFocus
Noni211Locked
Curcumin66Locked
Bee Propolis35Locked
Homeopathic Medicine: All35Locked
Syrian rue35Locked
Achiote24Locked
Allicin24Locked
Ashwagandha24Locked
Holy Basil24Locked
Apigenin23Locked
Berberine23Locked
Carvacrol23Locked
Coconut23Locked
Feverfew23Locked
Lupeol23Locked
Piperine23Locked
Pomegranate23Locked
Artemisinin22Locked
Black Pepper12Locked
Boerhaavia diffusa12Locked
Crocin22Locked
Elderberry12Locked
Emodin12Locked
Garlic22Locked
Oak12Locked
Saffron22Locked
Sea Cucumber12Locked
Thyme12Locked
Thymol12Locked
Turmeric22Locked
Verbascoside22Locked
Yarrow12Locked
Aloe Vera11Locked
Banana11Locked
Camu Camu 11Locked
Cannabinoids 11Locked
Cannabis11Locked
Carpolobia lutea11Locked
Chamomile11Locked
Cholesterol 11Locked
Cinnamaldehyde11Locked
Cinnamon11Locked
Coconut Husk/Fiber11Locked
Curcuminoids11Locked
Dill11Locked
Eugenol11Locked
Fisetin11Locked
Flavonoids11Locked
Fucoidan11Locked
Green Tea11Locked
Guava11Locked
Henna11Locked
Hesperidin11Locked
Licorice11Locked
Luteolin11Locked
Marjoram11Locked
Moringa oleifera11Locked
Myrtle (Myrtus communis L.)11Locked
Nettle11Locked
Nigella sativa (aka Black Seed)11Locked
Olive leaf extract11Locked
Onion11Locked
Orange11Locked
Oregano11Locked
Parthenolide11Locked
Piceatannol 11Locked
Piperidines11Locked
Piperlongumine 11Locked
Plum11Locked
Psychedelics:All 11Locked
Quercetin11Locked
Resveratrol11Locked
Safranal11Locked
Silver (nanoparticles)11Locked
Stevia11Locked
Stigmasterol11Locked
Ursolic Acid11Locked
Xanthohumol11Locked
Xylitol11Locked
Zataria multiflora11Locked
Zerumbone11Locked
2 Therapeutic Actions Researched for Leishmaniasis
NameACCKFocus
Laser Treatment: Low-Level110Locked
Exercise12Locked

View the Evidence:
94 Abstracts with Leishmaniasis Research

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In this study of 40 patients 50% of them showed an excellent response and 30% exhibited good improvement to the treatment..Jan 31, 2012

Pubmed Data : Nat Prod Commun. 2012 Feb ;7(2):195-6. PMID: 22474954
Article Published Date : Jan 31, 2012
Study Type : Human Study
Additional Links
Substances : Noni
Diseases : Leishmaniasis
Pharmacological Actions : Antiprotozoal Agents, Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Low-level laser therapy for the treatment of early stage cutaneous leishmaniasis.Aug 26, 2020

Pubmed Data : Dermatol Ther. 2020 Aug 27:e14232. Epub 2020 Aug 27. PMID: 32852075
Article Published Date : Aug 26, 2020
Study Type : Human Study
Additional Links
Diseases : Leishmaniasis
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Leishmanicidal
[+]

Novel insight into potential leishmanicidal activities of transdermal patches of Nigella sativa.Jun 27, 2021

Pubmed Data : Assay Drug Dev Technol. 2021 Jun 28. Epub 2021 Jun 28. PMID: 34182792
Article Published Date : Jun 27, 2021
Study Type : Human Study, In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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A methanol soluble extract of sea cucumber exhibited excellent anti-leishmanial activity.Jul 01, 2008

Pubmed Data : Parasitol Res. 2008 Jul;103(2):351-4. Epub 2008 May 2. PMID: 18452039
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sea Cucumber
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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Allicin could be promising for the treatment of human cutaneous leishmaniasis and the control of secondary bacterial infections.Jul 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2017 Jul 13 ;14(7). Epub 2017 Jul 13. PMID: 28703780
Article Published Date : Jul 12, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Allicin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Allicin has antileishmanial effects under in vitro and in vivo conditions and may be used in clinical applications.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(8):e0161296. Epub 2016 Aug 18. PMID: 27537199
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Allicin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Allicin, Leishmaniasis, Leishmanicidal
[+]

aloe-emodin showed antileishmanial effects under in vitro and in vivo conditions and may be used in clinical trials. Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2015 Apr ;5(2):96-9. Epub 2015 Jan 31. PMID: 26151018
Article Published Date : Mar 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Emodin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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An ethanol extract of P. harmala is efficient in the treatment of cutaneous leishmaniasis and is comparable with that of Glucantime.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Jundishapur J Microbiol. 2014 Jul ;7(7):e10992. Epub 2014 Jul 1. PMID: 25368792
Article Published Date : Jun 30, 2014
Study Type : Animal Study
Additional Links
Substances : Syrian rue
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Natural Substances Versus Drugs
[+]

Apigenin exhibits leishmanicidal effects against L. amazonensis-infected macrophages. Jan 31, 2016

Pubmed Data : PLoS Negl Trop Dis. 2016 Feb ;10(2):e0004442. Epub 2016 Feb 10. PMID: 26862901
Article Published Date : Jan 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Leishmaniasis
Pharmacological Actions : Antiparasitic Agents, Leishmanicidal
[+]

B. orellana extract showed a significant activity against promastigote and amastigote forms of L. amazonensis.Dec 31, 2010

Pubmed Data : Forsch Komplementmed. 2011 ;18(6):351-3. Epub 2011 Dec 9. PMID: 22189367
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Achiote
Diseases : Leishmaniasis
Pharmacological Actions : Antiprotozoal Agents
Additional Keywords : Plant Extracts
[+]

Berberine-loaded liposomes for the treatment of Leishmania infantum.Sep 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2020 Sep 9 ;12(9). Epub 2020 Sep 9. PMID: 32916948
Article Published Date : Sep 08, 2020
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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Coconut and holy basil rescued the affected mice from the disease.Feb 28, 2017

Pubmed Data : J Parasit Dis. 2017 Mar ;41(1):76-85. Epub 2016 Apr 4. PMID: 28316391
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Coconut, Holy Basil
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
Additional Keywords : Natural Substance Synergy, Plant Extracts
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Daily low doses of Brazilian propolis reduced the secondary chronic inflammatory process in the liver caused by L. amazonensis subcutaneous infection.Dec 27, 2015

Pubmed Data : Parasitol Res. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26711452
Article Published Date : Dec 27, 2015
Study Type : Animal Study
Additional Links
Substances : Bee Propolis
Diseases : Leishmaniasis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Feverfew extracts represents a promising alternative for the treatment of leishmaniasis.Jul 31, 2014

Pubmed Data : Exp Parasitol. 2014 Aug ;143:18-23. Epub 2014 May 5. PMID: 24810433
Article Published Date : Jul 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum.Jun 30, 2017

Pubmed Data : Cytokine. 2017 Jul ;95:97-101. Epub 2017 Feb 27. PMID: 28254560
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
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Lupeol induces immunity and protective efficacy in a murine model against visceral leishmaniasis.Aug 31, 2019

Pubmed Data : Parasitology. 2019 Sep ;146(11):1440-1450. Epub 2019 Jun 13. PMID: 31104636
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Leishmaniasis
Pharmacological Actions : Antiparasitic Agents, Immunomodulatory
[+]

Moderate intensity exercise is able to modulate the Th1 response that provides a protective effect against the development of leishmanial lesions.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Infect Microbiol. 2019 ;9:115. Epub 2019 May 3. PMID: 31131262
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Leishmaniasis
Therapeutic Actions : Exercise
Pharmacological Actions : Immunomodulatory
[+]

Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines.Sep 30, 2014

Pubmed Data : Homeopathy. 2014 Oct ;103(4):264-74. Epub 2014 Oct 3. PMID: 25439043
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Inflammation, Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
[+]

P harmala seeds extract showed significant in vitro and in vivo antileishmanial activities. Jul 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Res Med Sci. 2011 Aug ;16(8):1032-9. PMID: 22279479
Article Published Date : Jul 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Syrian rue
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2015 ;6:1368. Epub 2015 Dec 8. PMID: 26696979
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Black Pepper, Piperine
Diseases : Leishmaniasis
Pharmacological Actions : Apoptotic, Immunostimulatory, Leishmanicidal
[+]

Pomegranate juice shows antioxidant activity against cutaneous leishmaniasis-induced oxidative stress.Dec 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2017 Dec 18 ;14(12). Epub 2017 Dec 18. PMID: 29258248
Article Published Date : Dec 17, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Leishmaniasis
Pharmacological Actions : Antioxidants, Leishmanicidal
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S. ebulus extract may be a perfect therapeutic option for cutaneous leishmaniasis treatment.Dec 31, 2018

Pubmed Data : Parasite Immunol. 2019 Jan ;41(1):e12605. PMID: 30472741
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Elderberry
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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The ability of Bixa oil to control disease progression of established cutaneous leishmaniasis in mice was demonstrated.Apr 30, 2014

Pubmed Data : Phytother Res. 2014 May ;28(5):753-8. Epub 2013 Aug 27. PMID: 23983115
Article Published Date : Apr 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Achiote
Diseases : Leishmaniasis
Pharmacological Actions : Antiprotozoal Agents
Additional Keywords : Essential Oils
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The present study showed potent antileishmanial and antioxidant activity of oak extract.Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:208-15. Epub 2016 May 12. PMID: 27470357
Article Published Date : Jul 31, 2016
Study Type : Animal Study
Additional Links
Substances : Oak
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts, Selective Cytotoxicity
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These findings suggest a new option for antileishmanial chemotherapy at lower cost and nil toxicity.Jul 31, 2015

Pubmed Data : Indian J Exp Biol. 2015 Aug ;53(8):522-9. PMID: 26349315
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Boerhaavia diffusa, Holy Basil
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

These result concludes that withanolides in alcoholic fractions demonstrate a potent antileishmanial and immunomodulatory activities.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2017 ;4:55. Epub 2017 May 12. PMID: 28553635
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Thyme, yarrow and propolis are significantly more effective than glucantime in the treatment of Leishmaniasis in mice. Jan 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 Jan;72(1):94-100. Epub 2008 Jan 7. PMID: 19248657
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Thyme, Yarrow
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Superiority of Natural Substances versus Drugs
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Thymol and carvacrol are highly promising candidates for the development of effective and safe drugs in the fight against visceral leishmaniasis.May 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 May 30 ;24(11). Epub 2019 May 30. PMID: 31151304
Article Published Date : May 29, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs.Jan 14, 2017

Pubmed Data : Phytomedicine. 2017 Jan 15 ;24:87-95. Epub 2016 Nov 16. PMID: 28160866
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Interleukin-10 downregulation, Interleukin-12 upregulation, Interleukin-4 downregulation, Leishmanicidal, Nitric Oxide Enhancer
Additional Keywords : Natural Substance/Drug Synergy
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"Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants."Feb 28, 2011

Pubmed Data : J Antimicrob Chemother. 2011 Mar ;66(3):618-25. Epub 2011 Jan 14. PMID: 21393231
Article Published Date : Feb 28, 2011
Study Type : Viral
Additional Links
Substances : Fucoidan
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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"Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol."Oct 09, 2012

Pubmed Data : J Lipid Res. 2012 Oct 10. Epub 2012 Oct 10. PMID: 23060454
Article Published Date : Oct 09, 2012
Study Type : Review
Additional Links
Substances : Cholesterol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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A hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation could represent good strategy for the development of new antileishmanial agent.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:694934. Epub 2014 Jun 18. PMID: 25045693
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcuminoids, Turmeric
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Liposomal, Plant Extracts
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A systematic review of curcumin and its derivatives as valuable sources of antileishmanial agents.Mar 25, 2021

Pubmed Data : Acta Parasitol. 2021 Mar 26. Epub 2021 Mar 26. PMID: 33770343
Article Published Date : Mar 25, 2021
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Aloe vera leaf extract has leishmanial activity. May 01, 2007

Pubmed Data : J Med Microbiol. 2007 May;56(Pt 5):629-36. PMID: 17446285
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations.Dec 08, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Nanomedicine. 2010 Dec 9 ;5:1113-21. Epub 2010 Dec 9. PMID: 21270962
Article Published Date : Dec 08, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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Anti-parasitic activities of Allium sativum and Allium cepa against Trypanosoma b. brucei and Leishmania tarentolae.Apr 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicines (Basel). 2018 Apr 21 ;5(2). Epub 2018 Apr 21. PMID: 29690511
Article Published Date : Apr 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Onion
Diseases : Leishmaniasis, Trypanosomiasis
Pharmacological Actions : Antiparasitic Agents, Leishmanicidal
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds.Mar 31, 2008

Pubmed Data : Phytother Res. 2008 Apr ;22(4):455-7. PMID: 18167046
Article Published Date : Mar 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasisDec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Negl Trop Dis. 2020 Jan ;14(1):e0007843. Epub 2020 Jan 13. PMID: 31929528
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nettle
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Antileishmanial activity of verbascoside.Dec 31, 2016

Pubmed Data : Biochem Pharmacol. 2017 03 1 ;127:28-33. Epub 2016 Dec 23. PMID: 28017773
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Verbascoside
Diseases : Leishmaniasis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Leishmanicidal
[+]

Antileishmanial and immunomodulatory activities of lupeol.Sep 30, 2017

Pubmed Data : Int J Antimicrob Agents. 2017 Oct ;50(4):512-522. Epub 2017 Jun 29. PMID: 28669838
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Antileishmanial germacranolides from Calea zacatechichi.Apr 30, 2011

Pubmed Data : Planta Med. 2011 May ;77(7):749-53. Epub 2010 Dec 2. PMID: 21128202
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Psychedelics:All
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Antiparasitic effect of the Psidium guajava and Psidium brownianum.Mar 12, 2018

Pubmed Data : Food Chem Toxicol. 2018 Mar 13. Epub 2018 Mar 13. PMID: 29548852
Article Published Date : Mar 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Guava
Diseases : Leishmaniasis, Protozoan Infections
Pharmacological Actions : Antiparasitic Agents, Antiprotozoal Agents, Leishmanicidal
[+]

Antiprotozoal activity of Turkish Origanum onites essential oil and its components. Dec 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Dec 3 ;24(23). Epub 2019 Dec 3. PMID: 31817023
Article Published Date : Dec 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Marjoram
Diseases : Leishmaniasis, Protozoan Infections
Pharmacological Actions : Antiprotozoal Agents, Leishmanicidal
Additional Keywords : Essential Oils
[+]

Apigenin effect against Leishmania tropica amastigotes in vitro.Aug 31, 2020

Pubmed Data : J Parasit Dis. 2020 Sep ;44(3):574-578. Epub 2020 May 20. PMID: 32801509
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
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Artemisinin and its derivatives may be good alternatives for treating other non-malarial protozoan infections.Nov 16, 2016

Pubmed Data : Pharmacol Res. 2016 Nov 17 ;117:192-217. Epub 2016 Nov 17. PMID: 27867026
Article Published Date : Nov 16, 2016
Study Type : Review
Additional Links
Substances : Artemisinin
Diseases : Leishmaniasis, Protozoan Infections, Toxoplasma gondii Infection
Pharmacological Actions : Antiprotozoal Agents, Leishmanicidal
[+]

Artemisinin triggers induction of cell-cycle arrest and programmed cell death in Leishmania donovani promastigotes.Sep 01, 2007

Pubmed Data : J Med Microbiol. 2007 Sep;56(Pt 9):1213-8. PMID: 17761485
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Artemisinin
Diseases : Leishmaniasis
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Baccharis dracunculifolia compounds exhibit antileishmanial, antiplasmodial and cytotoxic activities.Dec 01, 2009

Pubmed Data : Fitoterapia. 2009 Dec;80(8):478-82. Epub 2009 Jun 18. PMID: 19540316
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis
Diseases : Leishmaniasis, Malaria
Pharmacological Actions : Antimalarials, Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Banana contains compounds which when metabolically transformed by fungi have leishmanicidal activity. May 01, 2004

Pubmed Data : Antimicrob Agents Chemother. 2004 May;48(5):1534-40. PMID: 15105102
Article Published Date : May 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Banana
Diseases : Leishmaniasis
[+]

Berberine chloride causes programmed cell death in Leishmania donovani promastigotes. Aug 07, 2009

Pubmed Data : Free Radic Res. 2009 Aug 7:1-10. Epub 2009 Aug 7. PMID: 19669998
Article Published Date : Aug 07, 2009
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Leishmaniasis
Pharmacological Actions : Apoptotic
[+]

Biologically active cannabinoids from high-potency Cannabis sativa displayed significant antibacterial and antifungal activities.May 21, 2009

Pubmed Data : J Nat Prod. 2009 May 22 ;72(5):906-11. PMID: 19344127
Article Published Date : May 21, 2009
Study Type : In Vitro Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Candida Infection , Leishmaniasis, Pseudomonas aeruginosa, Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents
[+]

Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.Apr 05, 2020

Pubmed Data : Eur J Pharm Sci. 2020 Apr 6:105335. Epub 2020 Apr 6. PMID: 32272211
Article Published Date : Apr 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Characterization of Antileishmanial Compounds from Lawsonia inermis L. Leaves.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:337. Epub 2017 May 31. PMID: 28620306
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Henna
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils: chemical composition, antimicrobial and antileishmanial activity.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2421695. Epub 2019 Jan 15. PMID: 30766611
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon, Oregano, Turmeric
Diseases : Leishmaniasis
Pharmacological Actions : Antimicrobial, Leishmanicidal
Additional Keywords : Essential Oils
[+]

Coconut husk fiber contains compounds with significant leishmanicidal activity. Apr 01, 2004

Pubmed Data : Res Microbiol. 2004 Apr;155(3):136-43. PMID: 15059625
Article Published Date : Apr 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Coconut, Coconut Husk/Fiber
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Curcumin has anti-Leishmanial activity. Apr 01, 2005

Pubmed Data : Parasitol Res. 2005 Apr;96(1):49-56. Epub 2005 Mar 17. PMID: 15772867
Article Published Date : Apr 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Curcumin has leischmaniacidal activity in vitro. Mar 01, 2002

Pubmed Data : Biol Pharm Bull. 2002 Mar;25(3):386-9. PMID: 11913540
Article Published Date : Mar 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Curcumin has leishmanicidal activity. Jan 01, 2002

Pubmed Data : Biol Pharm Bull. 2002 Jan;25(1):131-3. PMID: 11824543
Article Published Date : Jan 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leishmaniasis
Pharmacological Actions : Antioxidants, Leishmanicidal
[+]

Curcumin induces programmed cell death in Leishmania through its pro-oxidant and calcium-modulating activity. Jul 01, 2008

Pubmed Data : Apoptosis. 2008 Jul;13(7):867-82. PMID: 18506627
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leishmaniasis
Pharmacological Actions : Apoptotic, Cell cycle arrest, Leishmanicidal
[+]

Feverfew contains the compound parthenolide which exhibits antileishmanial activity. Jan 01, 2005

Pubmed Data : Antimicrob Agents Chemother. 2005 Jan;49(1):176-82. PMID: 15616293
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Flavonoids isolated from Stevia satureiifolia have leishmanicidal activities. Mar 16, 2016

Pubmed Data : Pharm Biol. 2016 Mar 17:1-8. Epub 2016 Mar 17. PMID: 26983579
Article Published Date : Mar 16, 2016
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Stevia
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Garlic with its immunomodulatory effects and apoptosis induction contributes to the treatment of leishmaniasis.Dec 29, 2015

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Dec 30. Epub 2015 Dec 30. PMID: 26721553
Article Published Date : Dec 29, 2015
Study Type : Review
Additional Links
Substances : Garlic
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Genetically modified mosquitos are being developed to create 'flying vaccinators.'Jun 01, 2010

Pubmed Data : Insect Mol Biol. 2010 Jun 1;19(3):391-8. Epub 2010 Mar 19. PMID: 20337749
Article Published Date : Jun 01, 2010
Study Type : Review
Additional Links
Diseases : Leishmaniasis, Vaccine-induced Toxicity
Additional Keywords : Flying Vaccines, Mad Science
[+]

Hesperidin targets Leishmania donovani Sterol C-24 reductase to fight against Leishmaniasis.Mar 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2021 Mar 30 ;6(12):8112-8118. Epub 2021 Mar 16. PMID: 33817470
Article Published Date : Mar 29, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

In vitro anti-leishmanial activity of Prunus armeniaca fractions on Leishmania tropica and molecular docking studies.Nov 02, 2020

Pubmed Data : J Photochem Photobiol B. 2020 Nov 3 ;213:112077. Epub 2020 Nov 3. PMID: 33220600
Article Published Date : Nov 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Plum
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

In vitro antileishmanial effects of saffron compounds, crocin and stigmasterol, on Iranian strain of Leishmania major.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Parasitol. 2021 Jan-Mar;16(1):151-158. PMID: 33786057
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron, Stigmasterol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Leishmanicidal activity of green tea leaves and pomegranate peel extracts on L. infantum.Jun 03, 2018

Pubmed Data : Nat Prod Res. 2018 Jun 4:1-7. Epub 2018 Jun 4. PMID: 29863902
Article Published Date : Jun 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Green Tea, Pomegranate
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Dose Response
[+]

Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil.Aug 31, 2018

Pubmed Data : Parasitol Res. 2018 Sep ;117(9):2855-2867. Epub 2018 Jun 28. PMID: 29955971
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Chamomile
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Essential Oils
[+]

Licochalcone a exhibits leishmanicidal activity in vitro and in experimental model of Leishmania.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Vet Sci. 2020 ;7:527. Epub 2020 Dec 10. PMID: 33363224
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Luteolin and quercetin are potent anti-leishmanial agent. Jun 01, 2000

Pubmed Data : Mol Med. 2000 Jun;6(6):527-41. PMID: 10972088
Article Published Date : Jun 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Luteolin, Quercetin
Diseases : Leishmaniasis
Pharmacological Actions : Apoptotic, Enzyme Inhibitors
[+]

M. citrifolia fruit juice exhibited antileishmanial activity against L. amazonensis axenic amastigotes.Jul 17, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Res Notes. 2018 Jul 18 ;11(1):492. Epub 2018 Jul 18. PMID: 30021621
Article Published Date : Jul 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Noni
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

M. dubia may be considered an important source for the development of novel treatment for diffuse cutaneous leishmaniasis and malaria treatment.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Rev Soc Bras Med Trop. 2016 Sep-Oct;49(5):586-592. PMID: 27812653
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Camu Camu
Diseases : Leishmaniasis, Malaria, Plasmodium Infections
Pharmacological Actions : Antiprotozoal Agents, Leishmanicidal
Additional Keywords : Plant Extracts
[+]

M1 complex can be a good candidate for a complementary therapy to conventional treatments for leishmaniasis.Oct 31, 2017

Pubmed Data : Cytokine. 2017 Nov ;99:80-90. Epub 2017 Jul 23. PMID: 28738234
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Olive leaf extract alters the cytokine profile of Leishmania major-infected macrophages.Feb 15, 2018

Pubmed Data : Parasite Immunol. 2018 Feb 16. Epub 2018 Feb 16. PMID: 29450889
Article Published Date : Feb 15, 2018
Study Type : In Vitro Study
Additional Links
Substances : Olive leaf extract
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Leishmanicidal, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Parthenolide has antileishmanial effects In vitro. Jun 09, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Microbiol. 2014 Jun 10 ;14:152. Epub 2014 Jun 10. PMID: 24913205
Article Published Date : Jun 09, 2014
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Leishmaniasis
Pharmacological Actions : Apoptotic, Leishmanicidal
[+]

Piperine and phenylamide acted synergistically on the leishmania amazonensis parasites.Nov 30, 2011

Pubmed Data : Phytochemistry. 2011 Dec ;72(17):2155-64. Epub 2011 Aug 30. PMID: 21885074
Article Published Date : Nov 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Piperidines, Piperine
Diseases : Leishmaniasis, Triglycerides: Elevated
Pharmacological Actions : Leishmanicidal, Nitric Oxide Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Resveratrol has potential antileishmanial activities in vitro.Dec 04, 2012

Pubmed Data : Planta Med. 2012 Dec 5. Epub 2012 Dec 5. PMID: 23225365
Article Published Date : Dec 04, 2012
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine.Sep 09, 2016

Pubmed Data : Exp Parasitol. 2016 Sep 10. Epub 2016 Sep 10. PMID: 27622989
Article Published Date : Sep 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Dill, Silver (nanoparticles)
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

The aim of this work is to collate all available published scientific reports in the literature on Carpolobia.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Rev. 2015 Jul-Dec;9(18):132-9. PMID: 26392711
Article Published Date : Jun 30, 2015
Study Type : Review
Additional Links
Substances : Carpolobia lutea
Diseases : Aspergillosis, Bacillus subtilis infections, Birth: Labor & Delivery, Candida Albicans, Diarrhea, Escherichia coli Infections, Fever, Hyperlipidemia, Leishmaniasis, Obesity, Pseudomonas aeruginosa, Rheumatism, Staphylococcus aureus infection, Sterility, Venereal Diseases: Bacterial
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Anti-pyretic , Antidiarrheals, Antimicrobial, Gastroprotective, Hypolipidemic, Immunomodulatory, Leishmanicidal
Additional Keywords : Anti-Obesity Agents, Natural Substances Versus Drugs, Plant Extracts
[+]

The components of crocus sativus have potential anti-bacterial and anti-parasitic effects.Mar 12, 2015

Pubmed Data : J Enzyme Inhib Med Chem. 2015 Mar 13:1-7. Epub 2015 Mar 13. PMID: 25766747
Article Published Date : Mar 12, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron, Safranal
Diseases : Helicobacter Pylori Infection, Leishmaniasis, Plasmodium Infections
Pharmacological Actions : Anti-Bacterial Agents, Antiparasitic Agents
[+]

The obtained data showed significant antileishmanial effects of Nigella sativa oil encapsulated nanoparticles.Nov 30, 2018

Pubmed Data : IET Nanobiotechnol. 2018 Dec ;12(8):1018-1026. PMID: 30964007
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

The results presented here highlight C. sinensis as a promising source of antileishmanial agents.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1780-1786. PMID: 28524774
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Orange
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The study revealed that both the test compounds have noticeable antioxidant and cytotoxic activities.Jul 30, 2017

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2017 Jul 31 ;63(6):73-78. Epub 2017 Jul 31. PMID: 28968213
Article Published Date : Jul 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde, Eugenol
Diseases : Leishmaniasis, Prostate Cancer
Pharmacological Actions : Cytotoxic, Leishmanicidal
[+]

These data show that Xanthohumol may have antileishmanial activity.Dec 11, 2016

Pubmed Data : Parasitology. 2016 Dec 12:1-13. Epub 2016 Dec 12. PMID: 27938439
Article Published Date : Dec 11, 2016
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

These findings showed that fisetin improves Meglumine antimoniate side effects as well as prevent the growth of promastigotes.May 31, 2017

Pubmed Data : Pathog Glob Health. 2017 Jun ;111(4):176-185. Epub 2017 Apr 7. PMID: 28385129
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal, Nitric Oxide Inhibitor
[+]

These results indicate that piperlongumine is a potential leishmanicidal candidate.May 14, 2018

Pubmed Data : Planta Med. 2018 May 15. Epub 2018 May 15. PMID: 29763945
Article Published Date : May 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

This article reviews the traditional uses and pharmacological effects of total extract and individual active alkaloids of P. harmala.Jun 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Rev. 2013 Jul ;7(14):199-212. PMID: 24347928
Article Published Date : Jun 30, 2013
Study Type : Review
Additional Links
Substances : Syrian rue
Diseases : Cancers: All, Depression, Leishmaniasis, Parkinson's Disease
Pharmacological Actions : Analgesics, Anti-Angiogenic, Anti-Bacterial Agents, Anti-Inflammatory Agents, Antidepressive Agents, Antinoceceptive , Antioxidants, Antiproliferative , Leishmanicidal, Vasodilator Agents
[+]

This study demonstrated potent antileishmanial effects of M. communis that might be a natural source for production of new antileishmanial agents.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Parasitol. 2015 Feb ;53(1):21-7. Epub 2015 Feb 27. PMID: 25748705
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Myrtle (Myrtus communis L.)
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Dose Response, Essential Oils, Plant Extracts
[+]

This study indicates that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.Feb 28, 2014

Pubmed Data : Z Naturforsch C. 2014 Mar-Apr;69(3-4):110-6. PMID: 24873031
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Turmeric contains compounds with anti-protozoal activity.Apr 02, 1999

Pubmed Data : Neurosci Lett. 1999 Apr 2;264(1-3):141-4. PMID: 10865470
Article Published Date : Apr 02, 1999
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leishmaniasis, Malaria
Pharmacological Actions : Antimalarials, Leishmanicidal
[+]

Ursolic acid is an interesting natural compound that should be considered for the development of prototype drugs against visceral leishmaniasis.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Parasitol Drugs Drug Resist. 2017 Apr ;7(1):1-11. Epub 2016 Dec 8. PMID: 27984757
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Verbascoside inhibits promastigote growth and arginase activity of Leishmania amazonensis.Jan 26, 2016

Pubmed Data : J Nat Prod. 2016 05 27 ;79(5):1459-63. Epub 2016 Apr 20. PMID: 27096224
Article Published Date : Jan 26, 2016
Study Type : In Vitro Study
Additional Links
Substances : Verbascoside
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Xylitol may have leishmanicidal activityMay 01, 2008

Pubmed Data : Exp Parasitol. 2008 May;119(1):74-9. Epub 2007 Dec 28. PMID: 18316079
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Xylitol
Diseases : Leishmaniasis
[+]

Z. multiflora might be a natural source of new anti-leishmanial agents of use against cutaneous leishmaniasis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2016 ;54(5):752-8. Epub 2015 Oct 8. PMID: 26449681
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Zataria multiflora
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Zerumbone has potential therapeutic use against L. donovani infection.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Infect Dis. 2016 Jan-Feb;20(1):48-55. Epub 2015 Nov 28. PMID: 26643969
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Leishmaniasis, Oxidative Stress
Pharmacological Actions : Antiparasitic Agents

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