Leptin Resistance

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3 Substances Researched for Leptin Resistance

Name	AC	CK
Curcumin	2	4
Acetyl-l-carnitine	1	2
Piperine	1	2

2 Problem Substances Researched for Leptin Resistance

Name	AC	CK	Focus
Leptin: Elevated Levels	1	5
Fructose	2	4

Research Articles 9
Cumulative Knowledge Score 14
Overall Research Rating GOOD

View the Evidence:
9 Abstracts with Leptin Resistance Research

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Leptin attenuates the anti-estrogen effect of tamoxifen in breast cancer.Nov 14, 2012

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Pubmed Data : Biomed Pharmacother. 2012 Nov 15. Epub 2012 Nov 15. PMID: 23199901

Article Published Date : Nov 14, 2012

Study Type : Human In Vitro

Additional Links

Diseases : Leptin: Elevated Levels, Leptin Resistance

Additional Keywords : Tamoxifen Resistance

Problem Substances : Leptin: Elevated Levels

[+]

A high-fructose, low-fat diet induces peripheral leptin resistance in less than 4 weeks in rats. Jun 13, 2011

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Pubmed Data : Physiol Behav. 2011 Jun 13. Epub 2011 Jun 13. PMID: 21684298

Article Published Date : Jun 13, 2011

Study Type : Animal Study

Additional Links

Diseases : Leptin Resistance

Problem Substances : Fructose

Adverse Pharmacological Actions : Endocrine disruption: Leptin resistance

[+]

Acetyl-l-carnitine supplementation partly reduces the leptin resistance that occurs in old rats, and improves ATP production in skeletal muscle mitochondria through an increase in mitochondrial protein content.Apr 01, 2002

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Pubmed Data : J Nutr.2002 Apr;132(4):636-42. PMID: 11925454

Article Published Date : Apr 01, 2002

Study Type : Animal Study

Additional Links

Substances : Acetyl-l-carnitine

Diseases : Aging, Leptin Resistance

[+]

Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Aug 31, 2015

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Pubmed Data : Cell Metab. 2015 Sep 1 ;22(3):448-59. Epub 2015 Jul 9. PMID: 26166747

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Circadian Dysregulation, Leptin Resistance

Additional Keywords : Circadian Clock Proteins

[+]

Curcumin might significantly decrease the level of insulin resistance and leptin resistance caused by the high fat diet.Jan 01, 2009

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Pubmed Data : J Atheroscler Thromb. 2009;16(6):870-7. Epub 2009 Dec 22. PMID: 19176142

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Insulin Resistance, Leptin Resistance, Obesity

Pharmacological Actions : Apoptotic

[+]

Curcumin prevents fructose-induced hepatic steatosis driven by hepatic insulin and leptin resistance.May 01, 2010

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Pubmed Data : Hepatology. 2010 May;51(5):1555-66. PMID: 20222050

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Fatty Liver, Insulin Resistance, Leptin Resistance

Pharmacological Actions : Hepatoprotective

[+]

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.Mar 02, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Physiol Genomics. 2010 Mar 3 ;41(1):9-20. Epub 2009 Dec 8. PMID: 19996157

Article Published Date : Mar 02, 2010

Study Type : Animal Study

Additional Links

Diseases : Leptin Resistance

[+]

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.Nov 01, 2008

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Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1370-5. Epub 2008 Aug 13. PMID: 18703413

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Leptin Resistance, Weight Problems

Additional Keywords : Drug Synergy

Problem Substances : Fructose

Adverse Pharmacological Actions : Endocrine disruption: Leptin resistance

[+]

Piperine can be considered as an effective bioactive molecule to suppress of body weight, improve insulin and leptin sensitivity, and regulating obesity.Sep 24, 2014

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Pubmed Data : Chem Biol Interact. 2014 Sep 25 ;221:42-51. Epub 2014 Jul 31. PMID: 25087745

Article Published Date : Sep 24, 2014

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : High Fat Diet, Insulin Resistance, Leptin Resistance, Obesity

Additional Keywords : Anti-Obesity Agents, Dose Response

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Focus Your Research

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View the Evidence: 9 Abstracts with Leptin Resistance Research

Limited to Members Only

Currently Available Sorting Options

Leptin attenuates the anti-estrogen effect of tamoxifen in breast cancer.Nov 14, 2012

A high-fructose, low-fat diet induces peripheral leptin resistance in less than 4 weeks in rats. Jun 13, 2011

Acetyl-l-carnitine supplementation partly reduces the leptin resistance that occurs in old rats, and improves ATP production in skeletal muscle mitochondria through an increase in mitochondrial protein content.Apr 01, 2002

Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Aug 31, 2015

Curcumin might significantly decrease the level of insulin resistance and leptin resistance caused by the high fat diet.Jan 01, 2009

Curcumin prevents fructose-induced hepatic steatosis driven by hepatic insulin and leptin resistance.May 01, 2010

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.Mar 02, 2010

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.Nov 01, 2008

Piperine can be considered as an effective bioactive molecule to suppress of body weight, improve insulin and leptin sensitivity, and regulating obesity.Sep 24, 2014

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Leptin Resistance

View the Evidence:
9 Abstracts with Leptin Resistance Research