Leukemia: Acute myelogenous leukemia (AML)

Name	AC	CK
Lactoferrin	1	10
Molasses	1	10
Feverfew	3	3
Alpinia galanga	1	2
Curcumin	2	2
Flavonoids	1	2
Mistletoe	2	2
Resveratrol	2	2
Rosemary	1	2
Willow Bark	1	2
Aloe Vera	1	1
Amygdalin	1	1
Black hellebore	1	1
Camptothecin	1	1
Carsonic Acid	1	1
Chinese Skullcap	1	1
Garlic	1	1
Gleditsia sinensis	1	1
Juniper	1	1
Milk Thistle	1	1
Nobiletin	1	1
Olive leaf extract	1	1
Silibinin	1	1
Thistle	1	1
Tripterygium wilfordii	1	1
Triptolide	1	1

Name	AC	CK
Benzene	4	31
Crude Oil/Petroleum	2	20
Tamoxifen	1	10
Benzene Metabolites	1	1
Hydroquinone	1	1

Name	AC	CK	Focus
Radiotherapy	3	23
Chemotherapy	2	15

[+]

Benzene exposure is associated with leukemia-associated changes in the peripheral blood lymphocytes of workers.Jan 07, 2011

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Pubmed Data : Carcinogenesis. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216845

Article Published Date : Jan 07, 2011

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Problem Substances : Benzene

Adverse Pharmacological Actions : Carcinogen

[+]

Crude oil exposure has been linked to acute myelogenous leukemia and multiple myeloma, in part due to benzene.Feb 01, 2008

Click here to read the entire abstract

Pubmed Data : Cancer Causes Control. 2008 Feb;19(1):13-23. Epub 2007 Sep 29. PMID: 17906934

Article Published Date : Feb 01, 2008

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Multiple Myeloma

Problem Substances : Benzene, Crude Oil/Petroleum

[+]

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Exp Pathol. 2014 ;7(5):2172-8. Epub 2014 Apr 15. PMID: 24966925

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Ginsenosides

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Anti-Angiogenic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Lactoferrin reduces the duration and severity of infection in neutropenic patients receiving chemotherapy for acute myleogenous leukemia. Apr 01, 1989

Click here to read the entire abstract

Pubmed Data : Eur J Clin Microbiol Infect Dis. 1989 Apr;8(4):310-3. PMID: 2497005

Article Published Date : Apr 01, 1989

Study Type : Human Study

Additional Links

Substances : Lactoferrin

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Neutropenia, Neutropenia: Chemotherapy Induced, Neutropenia: Cyclic

[+]

Offshore workers have a higher risk of acute myelogenous leukemia, probably due to benzene exposure.Oct 21, 2004

Click here to read the entire abstract

Pubmed Data : Tidsskr Nor Laegeforen. 2004 Oct 21;124(20):2627-9. PMID: 15534638

Article Published Date : Oct 21, 2004

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Problem Substances : Benzene, Crude Oil/Petroleum

[+]

Supplementation with molasses may have therapeutic value in the treatment of acute myelogeneous leukemia. Apr 01, 2006

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2006 Apr;12(3):311-5. PMID: 16646731

Article Published Date : Apr 01, 2006

Study Type : Human Study

Additional Links

Substances : Molasses

Diseases : Leukemia: Acute myelogenous leukemia (AML)

[+]

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.Mar 01, 1997

Click here to read the entire abstract

Pubmed Data : Med Oncol. 1997 Mar;14(1):61-2. PMID: 9232614

Article Published Date : Mar 01, 1997

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Leukemia: Acute myelogenous leukemia (AML)

Additional Keywords : Drug: Tamoxifen

Problem Substances : Tamoxifen

Adverse Pharmacological Actions : Carcinogenic

[+]

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

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Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukemia: Acute myelogenous leukemia (AML) , Lymphoma, Myelodysplastic Syndrome, Radiation Induced Illness

Additional Keywords : Iatrogenic Disease

Anti Therapeutic Actions : Chemotherapy, Radiotherapy

[+]

There is an increased incidence of myelodysplastic syndrome and acute myeloid leukemia following breast cancer treatment with radiation alone or combined with chemotherapy: a registry cohort analysis 1990-2005.Dec 31, 2010

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Pubmed Data : BMC Cancer. 2011 ;11:260. Epub 2011 Jun 21. PMID: 21693006

Article Published Date : Dec 31, 2010

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Chemotherapy and Radiation Toxicity, Leukemia: Acute myelogenous leukemia (AML) , Myelodysplastic Syndromes, Radiotherapy

Anti Therapeutic Actions : Radiotherapy

Adverse Pharmacological Actions : Myelotoxicity, Radiotoxic

[+]

Exposure of NK cells to morphine decreased their ability to induce apoptosis in K562 cells.Oct 14, 2019

Click here to read the entire abstract

Pubmed Data : Brain Behav Immun. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626971

Article Published Date : Oct 14, 2019

Study Type : Human In Vitro

Additional Links

Diseases : Cancers: All, Leukemia: Acute myelogenous leukemia (AML)

Additional Keywords : Increased Risk

Problem Substances : Morphine

[+]

Acute non-lymphocytic leukaemia and myelofibrosis following sequential hemibody irradiation for prostatic carcinoma has been reported.Sep 01, 1991

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Pubmed Data : Clin Oncol (R Coll Radiol). 1991 Sep;3(5):288-90. PMID: 1931775

Article Published Date : Sep 01, 1991

Study Type : Human: Case Report

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Myelofibrosis, Prostate Cancer, Radiation Induced Illness

Anti Therapeutic Actions : Radiotherapy

[+]

Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-D-glucan.Jul 14, 2020

Click here to read the entire abstract

Pubmed Data : Carbohydr Polym. 2020 Jul 15 ;240:116329. Epub 2020 Apr 23. PMID: 32475588

Article Published Date : Jul 14, 2020

Study Type : Animal Study

Additional Links

Substances : Selenium

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Cytotoxic

[+]

Anti-tumor activity of verbascoside loaded gold nanoparticles.Nov 30, 2014

Click here to read the entire abstract

Pubmed Data : J Biomed Nanotechnol. 2014 Dec ;10(12):3638-46. PMID: 26000377

Article Published Date : Nov 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Gold (nanoparticles), Verbascoside

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Anticancer Drugs. 2017 08 ;28(7):723-738. PMID: 28471807

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Deguelin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Chemotherapeutic

[+]

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells. Jul 08, 2008

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID: 18374481

Article Published Date : Jul 08, 2008

Study Type : Animal Study

Additional Links

Substances : Alpinia galanga, Flavonoids

Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemosensitizer

[+]

Ginsenoside Rh2 had good anti-tumor effect in vivo.Jan 31, 2016

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2016 Feb ;41(4):700-704. PMID: 28871696

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

Additional Keywords : Histone deacetylase inhibitor

[+]

Hispolon may have the potential to serve as a therapeutic tool to treat acute myeloid leukemia.Oct 22, 2013

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2013 Oct 23 ;61(42):10063-73. Epub 2013 Oct 15. PMID: 24093560

Article Published Date : Oct 22, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Phellinus Linteus

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Rosemary may have therapeutic value in the treatment of acute myeloid leukemia. Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Oncology. 2008;75(3-4):203-14. Epub 2008 Oct 14. PMID: 18852491

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Rosemary

Diseases : Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antioxidants

[+]

Willow leaf extract contains anti-tumor agents effective against acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in mice. Jan 31, 2007

Click here to read the entire abstract

Pubmed Data : PLoS One. 2007 Jan 31;2(1):e178. PMID: 17264881

Article Published Date : Jan 31, 2007

Study Type : Animal Study

Additional Links

Substances : Willow Bark

Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)

[+]

"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell."Jul 01, 1997

Click here to read the entire abstract

Pubmed Data : Nat Med. 1997 Jul ;3(7):730-7. PMID: 9212098

Article Published Date : Jul 01, 1997

Study Type : In Vitro Study

Additional Links

Diseases : Cancer Stem Cells, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative

[+]

Amygdalin (laetrile) is antiproliferative and induces programmed cell death in Acute Myeloid Leukemia. Feb 01, 2003

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2003 Feb;26(2):157-61. PMID: 12643594

Article Published Date : Feb 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Amygdalin

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Myeloid Leukemia: Acute

[+]

Anti-leukemia effect and mechanism of oridonin on omatinib-sensitive and imatinib-resistant K562 cells.Sep 30, 2017

Click here to read the entire abstract

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Oct ;25(5):1378-1383. PMID: 29070111

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis.Jan 28, 2020

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2020 Jan 29. Epub 2020 Jan 29. PMID: 32007276

Article Published Date : Jan 28, 2020

Study Type : In Vitro Study

Additional Links

Substances : Artemisinin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic, Chemosensitizer

[+]

Artesunate with bortezomib shows a significant synergistic effects on proliferation, apoptosis and autophagy of MV4-11 cell lines.Mar 13, 2019

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Pubmed Data : Zhonghua Xue Ye Xue Za Zhi. 2019 Mar 14 ;40(3):204-208. PMID: 30929387

Article Published Date : Mar 13, 2019

Study Type : In Vitro Study

Additional Links

Substances : Artesunate

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Benzene and its metabolites are leukemogenic.May 01, 2010

Click here to read the entire abstract

Pubmed Data : Leukemia. 2010 May;24(5):986-91. Epub 2010 Mar 25. PMID: 20339439

Article Published Date : May 01, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Acute myelogenous leukemia (AML)

Problem Substances : Benzene, Benzene Metabolites, Hydroquinone

[+]

Black hellebore (Helleborus niger) induces programmed cell death in the Actue lymphoblastic leukemia (ALL) cells and Acute myeloid leukemia (AML). Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : Pediatr Blood Cancer. 2009 Apr;52(4):464-9. PMID: 19090543

Article Published Date : Apr 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Black hellebore

Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic

[+]

Camptothecin acts synergistically with imatinib and overcomes imatinib resistance in chronic myelogenous leukemia (CML) cells.Jul 08, 2007

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2007 Jul 8;252(1):75-85. Epub 2007 Jan 16. PMID: 17223257

Article Published Date : Jul 08, 2007

Study Type : In Vitro Study

Additional Links

Substances : Camptothecin

Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Chemosensitizer

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

Clove mistletoe had a potent natural anticancer activity.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Adv Pharmacol Sci. 2016 ;2016:3242698. Epub 2016 Mar 23. PMID: 27099614

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Mistletoe

Diseases : Animal Cancers, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Cytotoxic

Additional Keywords : Plant Extracts

[+]

Creeping daisy extract has apoptotic and anti-leukemia activity in MEG-01 cells. Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Afr J Tradit Complement Altern Med. 2017 ;14(3):167-174. Epub 2017 Mar 1. PMID: 28480428

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Daisy

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

[+]

Curcumin induces programmed cell death and disturbs cell cycle progression in leukemia cells.Jan 01, 2002

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2002;22(4):295-8. PMID: 12674762

Article Published Date : Jan 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Promyelocytic leukemia

Pharmacological Actions : Apoptotic, Cell cycle arrest

[+]

Diosmetin induces apoptosis of acute myeloid leukemia cells.Jan 04, 2018

Click here to read the entire abstract

Pubmed Data : Mol Pharm. 2018 03 5 ;15(3):1353-1360. Epub 2018 Feb 7. PMID: 29412683

Article Published Date : Jan 04, 2018

Study Type : In Vitro Study

Additional Links

Substances : Diosmetin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Estrogen Receptor Beta

[+]

Effects of cultivated Cordyceps sinensis on proliferation and apoptosis of human leukemia K562 cells.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 May ;43(10):2134-2139. PMID: 29933683

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis.Sep 29, 2020

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2020 Sep 30 ;40(9):1230-1238. PMID: 32990229

Article Published Date : Sep 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro - Article 2. Jun 01, 2005

Click here to read the entire abstract

Pubmed Data : Blood. 2005 Jun 1;105(11):4163-9. Epub 2005 Feb 1. PMID: 15687234

Article Published Date : Jun 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Feverfew

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antineoplastic Agents, Apoptotic, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

[+]

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro. Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Expert Opin Biol Ther. 2005 Sep;5(9):1147-52. PMID: 16120045

Article Published Date : Sep 01, 2005

Study Type : Commentary

Additional Links

Substances : Feverfew

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor

[+]

Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.Dec 15, 2007

Click here to read the entire abstract

Pubmed Data : Blood. 2007 Dec 15;110(13):4427-35. Epub 2007 Sep 5. PMID: 17804695

Article Published Date : Dec 15, 2007

Study Type : In Vitro Study

Additional Links

Substances : Feverfew

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Cytotoxicity

[+]

Garlic contains a compound known as ajoene which may be therapeutic in multi-drug resistant AML patients. Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Leuk Res. 2004 Jul;28(7):667-71. PMID: 15158086

Article Published Date : Jul 01, 2004

Study Type : Review

Additional Links

Substances : Garlic

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Additional Keywords : Multi-Drug Resistant Cancers

[+]

Ginsenoside 20(S)-Rh2 induces apoptosis and differentiation of acute myeloid leukemia cells.Sep 05, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 Sep 6 ;65(35):7687-7697. Epub 2017 Aug 23. PMID: 28793767

Article Published Date : Sep 05, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Ginsenoside Rh2 induces apoptosis and autophagy of K562 cells by activating p38.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2017 Jan ;42(1):146-151. PMID: 28945040

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Ginsenoside Rh2 inhibits proliferation and promotes apoptosis of leukemia KG1-α cells.May 31, 2014

Click here to read the entire abstract

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jun ;30(6):565-8. PMID: 24909273

Article Published Date : May 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

[+]

Gleditsia sinensis might be potentially used as a chemotherapeutic drug to treat patients with acute and chronic myelogenous leukemia.Sep 01, 2003

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2003 Sep-Oct;10(5):1601-7. PMID: 12883747

Article Published Date : Sep 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Gleditsia sinensis

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Apoptotic

[+]

High dose vitamin C can inhibit the proliferation and promote the apoptosis of acute myeloid leukemia cells.May 31, 2020

Click here to read the entire abstract

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Jun ;28(3):833-841. PMID: 32552944

Article Published Date : May 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Selective Cytotoxicity

[+]

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells.May 31, 2017

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2017 Jun ;39(6):1010428317705768. PMID: 28631564

Article Published Date : May 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Telomerase Inhibitor

[+]

Induction of apoptosis by piceatannol in human leukemic U937 cells.Mar 31, 2008

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2008 Apr ;19(4):961-7. PMID: 18357382

Article Published Date : Mar 31, 2008

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation

[+]

Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells.Nov 25, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2018 Nov 26 ;8(1):17377. Epub 2018 Nov 26. PMID: 30478296

Article Published Date : Nov 25, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Mangiferin inhibits MV4-11 cell proliferation, arrests cell cycle progression and promotes apoptosis.Mar 31, 2019

Click here to read the entire abstract

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr ;27(2):385-389. PMID: 30998142

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

miR-497 plays a key role in Tanshinone IIA-attenuated proliferation in OCI-AML3 cells via the MAPK/ERK1/2 pathway.Mar 10, 2020

Click here to read the entire abstract

Pubmed Data : Cytotechnology. 2020 Mar 11. Epub 2020 Mar 11. PMID: 32162175

Article Published Date : Mar 10, 2020

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , MicroRNA modulator

[+]

Myricetin exhibits potent anti-leukemia activity by interfering with purine nucleotides biosynthetic pathway.Jan 01, 2016

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2016 09 2 ;477(4):915-922. Epub 2016 Jul 1. PMID: 27378425

Article Published Date : Jan 01, 2016

Study Type : In Vitro Study

Additional Links

Substances : Myricetin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

Nobiletin inhibited HL-60 cell proliferation through inducing cell-cycle arrest and apoptosis and could serve as a potential additional chemotherapeutic agent for treating AML.Nov 30, 2014

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2014 Dec ;35(12):11903-11. Epub 2014 Aug 28. PMID: 25164609

Article Published Date : Nov 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, P38 Mitogen-Activated Protein Kinase Modulator

[+]

Olive leaf extract inhibits growth and differentiation of human promyelocytic leukemia cells. May 01, 2007

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2007 May;71(5):1306-12. Epub 2007 May 7. PMID: 17485840

Article Published Date : May 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Promyelocytic leukemia

[+]

Parthenolide or piperlongumine that induce almost complete glutathione depletion and severe cell death in AML cells.Nov 21, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biol Chem. 2013 Nov 22 ;288(47):33542-58. Epub 2013 Oct 2. PMID: 24089526

Article Published Date : Nov 21, 2013

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide, Piperlongumine

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Oxidative Stress

Pharmacological Actions : Cytotoxic

[+]

Piceatannol suppresses TNF-α shedding in U937 cells.Aug 31, 2012

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2012 Sep 1 ;84(5):670-80. Epub 2012 Jun 15. PMID: 22705645

Article Published Date : Aug 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Puerarin can selectively inhibit the proliferation of 4 AML cell lines.Mar 31, 2010

Click here to read the entire abstract

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Apr ;18(2):296-9. PMID: 20416155

Article Published Date : Mar 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Promyelocytic leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Selective Antiproliferation

[+]

Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing autophagy.Nov 02, 2020

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2020 Nov 3. Epub 2020 Nov 3. PMID: 33141989

Article Published Date : Nov 02, 2020

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Autophagy Up-regulation, Chemosensitizer

[+]

Recent progress of oridonin and its derivatives for the treatment of acute myelogenous leukemia.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Mini Rev Med Chem. 2020 ;20(6):483-497. PMID: 31660811

Article Published Date : Dec 31, 2019

Study Type : Review

Additional Links

Substances : Oridonin

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Chemotherapeutic

[+]

Restoration of TET2 function blocks aberrant self-renewal and leukemia progression.Sep 06, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell. 2017 Sep 7 ;170(6):1079-1095.e20. Epub 2017 Aug 17. PMID: 28823558

Article Published Date : Sep 06, 2017

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Apoptotic, Chemotherapeutic

[+]

Resveratrol inhibits proliferation and induces differentiation of myeloid leukemia cells.Jun 01, 2002

Click here to read the entire abstract

Pubmed Data : Int J Hematol. 2002 Jun;75(5):528-33. PMID: 12095155

Article Published Date : Jun 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor

Additional Keywords : Drug-Plant-Vitamin Synergies, Stilbenes

[+]

Resveratrol reverses doxorubicin resistance in acute myeloid leukemia cells.Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Environ Health. 2008;7:21. Epub 2008 May 30. PMID: 20350534

Article Published Date : Jan 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Doxorubicin, Stilbenes

[+]

Sonchus oleraceus and juniper extracts had anti-tumor effects.Jun 04, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Jun 5 ;185:289-99. Epub 2016 Mar 19. PMID: 27001625

Article Published Date : Jun 04, 2016

Study Type : In Vitro Study

Additional Links

Substances : Juniper, Thistle

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Supercritical extracts of aloe vera exhibit antitumor properties and modulate antioxidant enzymes. Nov 24, 2009

Click here to read the entire abstract

Pubmed Data : Curr Med Chem. 2009 Nov 24. Epub 2009 Nov 24. PMID: 19941474

Article Published Date : Nov 24, 2009

Study Type : In Vitro Study

Additional Links

Substances : Aloe Vera

Diseases : Acute lymphoblastic leukemia (ALL), Colon Cancer, Leukemia: Acute myelogenous leukemia (AML) , Tumors

Pharmacological Actions : Anti-Tumor

Additional Keywords : Selective Cytotoxicity

[+]

Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis.Oct 31, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Nov ;95:477-486. Epub 2017 Sep 12. PMID: 28865368

Article Published Date : Oct 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2020 ;20:379. Epub 2020 Aug 7. PMID: 32782437

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831

Article Published Date : Aug 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Carsonic Acid, Curcumin, Milk Thistle, Silibinin

Diseases : Leukemia: Acute myelogenous leukemia (AML) , Oxidative Stress

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.Jul 02, 2010

Click here to read the entire abstract

Pubmed Data : Curr Mol Pharmacol. 2010 Jul 2. Epub 2010 Jul 2. PMID: 20594187

Article Published Date : Jul 02, 2010

Study Type : In Vitro Study

Additional Links

Substances : Tripterygium wilfordii, Triptolide

Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic Lymphocytic Leukemia (CLL), Leukemia: Chronic myelogenous leukemia (CML) , Multiple Myeloma, Myelodysplastic Syndrome

Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor

[+]

V. album extract increases antileukemic effectiveness of doxorubicin against resistant K562 cells.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2016 Mar ;30(3):485-95. Epub 2015 Dec 21. PMID: 26692465

Article Published Date : Feb 29, 2016

Study Type : In Vitro Study

Additional Links

Substances : Mistletoe

Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Plant Extracts

[+]

Wogonin, a compound found within Chinese Skullcap, significantly suppresses differentiation of leukemia cells in acute myeloid leukemia.Apr 01, 2008

Click here to read the entire abstract

Pubmed Data : Cancer Sci. 2008 Apr;99(4):689-95. PMID: 18377421

Article Published Date : Apr 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Chinese Skullcap

Diseases : Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)

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View the Evidence: 66 Abstracts with Leukemia: Acute myelogenous leukemia (AML) Research

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Benzene exposure is associated with leukemia-associated changes in the peripheral blood lymphocytes of workers.Jan 07, 2011

Crude oil exposure has been linked to acute myelogenous leukemia and multiple myeloma, in part due to benzene.Feb 01, 2008

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Lactoferrin reduces the duration and severity of infection in neutropenic patients receiving chemotherapy for acute myleogenous leukemia. Apr 01, 1989

Offshore workers have a higher risk of acute myelogenous leukemia, probably due to benzene exposure.Oct 21, 2004

Supplementation with molasses may have therapeutic value in the treatment of acute myelogeneous leukemia. Apr 01, 2006

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.Mar 01, 1997

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

There is an increased incidence of myelodysplastic syndrome and acute myeloid leukemia following breast cancer treatment with radiation alone or combined with chemotherapy: a registry cohort analysis 1990-2005.Dec 31, 2010

Exposure of NK cells to morphine decreased their ability to induce apoptosis in K562 cells.Oct 14, 2019

Acute non-lymphocytic leukaemia and myelofibrosis following sequential hemibody irradiation for prostatic carcinoma has been reported.Sep 01, 1991

Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-D-glucan.Jul 14, 2020

Anti-tumor activity of verbascoside loaded gold nanoparticles.Nov 30, 2014

Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro.Dec 31, 2016

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells. Jul 08, 2008

Ginsenoside Rh2 had good anti-tumor effect in vivo.Jan 31, 2016

Hispolon may have the potential to serve as a therapeutic tool to treat acute myeloid leukemia.Oct 22, 2013

Rosemary may have therapeutic value in the treatment of acute myeloid leukemia. Jan 01, 2008

Willow leaf extract contains anti-tumor agents effective against acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in mice. Jan 31, 2007

"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell."Jul 01, 1997

Amygdalin (laetrile) is antiproliferative and induces programmed cell death in Acute Myeloid Leukemia. Feb 01, 2003

Anti-leukemia effect and mechanism of oridonin on omatinib-sensitive and imatinib-resistant K562 cells.Sep 30, 2017

Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis.Jan 28, 2020

Artesunate with bortezomib shows a significant synergistic effects on proliferation, apoptosis and autophagy of MV4-11 cell lines.Mar 13, 2019

Benzene and its metabolites are leukemogenic.May 01, 2010

Black hellebore (Helleborus niger) induces programmed cell death in the Actue lymphoblastic leukemia (ALL) cells and Acute myeloid leukemia (AML). Apr 01, 2009

Camptothecin acts synergistically with imatinib and overcomes imatinib resistance in chronic myelogenous leukemia (CML) cells.Jul 08, 2007

Clove mistletoe had a potent natural anticancer activity.Dec 31, 2015

Creeping daisy extract has apoptotic and anti-leukemia activity in MEG-01 cells. Dec 31, 2016

Curcumin induces programmed cell death and disturbs cell cycle progression in leukemia cells.Jan 01, 2002

Diosmetin induces apoptosis of acute myeloid leukemia cells.Jan 04, 2018

Effects of cultivated Cordyceps sinensis on proliferation and apoptosis of human leukemia K562 cells.Apr 30, 2018

Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis.Sep 29, 2020

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro - Article 2. Jun 01, 2005

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro. Sep 01, 2005

Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.Dec 15, 2007

Garlic contains a compound known as ajoene which may be therapeutic in multi-drug resistant AML patients. Jul 01, 2004

Ginsenoside 20(S)-Rh2 induces apoptosis and differentiation of acute myeloid leukemia cells.Sep 05, 2017

Ginsenoside Rh2 induces apoptosis and autophagy of K562 cells by activating p38.Dec 31, 2016

Ginsenoside Rh2 inhibits proliferation and promotes apoptosis of leukemia KG1-α cells.May 31, 2014

Gleditsia sinensis might be potentially used as a chemotherapeutic drug to treat patients with acute and chronic myelogenous leukemia.Sep 01, 2003

High dose vitamin C can inhibit the proliferation and promote the apoptosis of acute myeloid leukemia cells.May 31, 2020

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells.May 31, 2017

Induction of apoptosis by piceatannol in human leukemic U937 cells.Mar 31, 2008

Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells.Nov 25, 2018

Mangiferin inhibits MV4-11 cell proliferation, arrests cell cycle progression and promotes apoptosis.Mar 31, 2019

miR-497 plays a key role in Tanshinone IIA-attenuated proliferation in OCI-AML3 cells via the MAPK/ERK1/2 pathway.Mar 10, 2020

Myricetin exhibits potent anti-leukemia activity by interfering with purine nucleotides biosynthetic pathway.Jan 01, 2016

Nobiletin inhibited HL-60 cell proliferation through inducing cell-cycle arrest and apoptosis and could serve as a potential additional chemotherapeutic agent for treating AML.Nov 30, 2014

Olive leaf extract inhibits growth and differentiation of human promyelocytic leukemia cells. May 01, 2007

Parthenolide or piperlongumine that induce almost complete glutathione depletion and severe cell death in AML cells.Nov 21, 2013

Piceatannol suppresses TNF-α shedding in U937 cells.Aug 31, 2012

Puerarin can selectively inhibit the proliferation of 4 AML cell lines.Mar 31, 2010

Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing autophagy.Nov 02, 2020

Recent progress of oridonin and its derivatives for the treatment of acute myelogenous leukemia.Dec 31, 2019

Restoration of TET2 function blocks aberrant self-renewal and leukemia progression.Sep 06, 2017

Resveratrol inhibits proliferation and induces differentiation of myeloid leukemia cells.Jun 01, 2002

Resveratrol reverses doxorubicin resistance in acute myeloid leukemia cells.Jan 01, 2008

Sonchus oleraceus and juniper extracts had anti-tumor effects.Jun 04, 2016

Supercritical extracts of aloe vera exhibit antitumor properties and modulate antioxidant enzymes. Nov 24, 2009

Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis.Oct 31, 2017

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis.Dec 31, 2019

The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.Aug 01, 2010

Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.Jul 02, 2010

V. album extract increases antileukemic effectiveness of doxorubicin against resistant K562 cells.Feb 29, 2016

Wogonin, a compound found within Chinese Skullcap, significantly suppresses differentiation of leukemia cells in acute myeloid leukemia.Apr 01, 2008

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Leukemia: Acute myelogenous leukemia (AML)

View the Evidence:
66 Abstracts with Leukemia: Acute myelogenous leukemia (AML) Research