Leukemia: Acute myelogenous leukemia (AML)

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51 Substances Researched for Leukemia: Acute myelogenous leukemia (AML)
NameACCKFocus
Ginsenosides515Locked
Lactoferrin110Locked
Molasses110Locked
Feverfew33Locked
Alpinia galanga12Locked
Curcumin22Locked
Deguelin12Locked
Flavonoids12Locked
Gold (nanoparticles)12Locked
Mistletoe22Locked
Oridonin22Locked
Phellinus Linteus12Locked
Piceatannol 22Locked
Puerarin22Locked
Resveratrol22Locked
Rosemary12Locked
Selenium12Locked
Tanshinone IIA22Locked
Verbascoside12Locked
Vitamin C22Locked
Willow Bark12Locked
Aloe Vera11Locked
Amygdalin11Locked
Artemisinin11Locked
Artesunate11Locked
Black hellebore11Locked
Camptothecin11Locked
Carsonic Acid11Locked
Chinese Skullcap 11Locked
Cordyceps sinensis11Locked
Daisy11Locked
Diosmetin11Locked
EGCG (Epigallocatechin gallate)11Locked
Garlic11Locked
Gleditsia sinensis11Locked
Honeysuckle11Locked
Indole-3-Carbinol11Locked
Juniper11Locked
Mangiferin11Locked
Milk Thistle11Locked
Myricetin11Locked
Nobiletin 11Locked
Olive leaf extract11Locked
Parthenolide11Locked
Piperlongumine 11Locked
Silibinin11Locked
Thistle11Locked
Tocotrienol: Gamma11Locked
Tripterygium wilfordii11Locked
Triptolide11Locked
Vitamin E11Locked
6 Problem Substances Researched for Leukemia: Acute myelogenous leukemia (AML)
NameACCKFocus
Benzene431Locked
Crude Oil/Petroleum220Locked
Tamoxifen110Locked
Morphine15Locked
Benzene Metabolites11Locked
Hydroquinone11Locked
2 Problematic Actions Researched for Leukemia: Acute myelogenous leukemia (AML)
NameACCKFocus
Radiotherapy323Locked
Chemotherapy215Locked
Related Topics

Leukemia: Acute myelogenous leukemia (AML) is a Sub of the following Topic

View the Evidence:
83 Abstracts with Leukemia: Acute myelogenous leukemia (AML) Research

[+]

Benzene exposure is associated with leukemia-associated changes in the peripheral blood lymphocytes of workers.Jan 07, 2011

Pubmed Data : Carcinogenesis. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216845
Article Published Date : Jan 07, 2011
Study Type : Human Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene
Adverse Pharmacological Actions : Carcinogen
[+]

Crude oil exposure has been linked to acute myelogenous leukemia and multiple myeloma, in part due to benzene.Feb 01, 2008

Pubmed Data : Cancer Causes Control. 2008 Feb;19(1):13-23. Epub 2007 Sep 29. PMID: 17906934
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Multiple Myeloma
Problem Substances : Benzene, Crude Oil/Petroleum
[+]

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2014 ;7(5):2172-8. Epub 2014 Apr 15. PMID: 24966925
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Anti-Angiogenic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Lactoferrin reduces the duration and severity of infection in neutropenic patients receiving chemotherapy for acute myleogenous leukemia. Apr 01, 1989

Pubmed Data : Eur J Clin Microbiol Infect Dis. 1989 Apr;8(4):310-3. PMID: 2497005
Article Published Date : Apr 01, 1989
Study Type : Human Study
Additional Links
Substances : Lactoferrin
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Neutropenia, Neutropenia: Chemotherapy Induced, Neutropenia: Cyclic
[+]

Offshore workers have a higher risk of acute myelogenous leukemia, probably due to benzene exposure.Oct 21, 2004

Pubmed Data : Tidsskr Nor Laegeforen. 2004 Oct 21;124(20):2627-9. PMID: 15534638
Article Published Date : Oct 21, 2004
Study Type : Human Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene, Crude Oil/Petroleum
[+]

Supplementation with molasses may have therapeutic value in the treatment of acute myelogeneous leukemia. Apr 01, 2006

Pubmed Data : J Altern Complement Med. 2006 Apr;12(3):311-5. PMID: 16646731
Article Published Date : Apr 01, 2006
Study Type : Human Study
Additional Links
Substances : Molasses
Diseases : Leukemia: Acute myelogenous leukemia (AML)
[+]

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.Mar 01, 1997

Pubmed Data : Med Oncol. 1997 Mar;14(1):61-2. PMID: 9232614
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Leukemia: Acute myelogenous leukemia (AML)
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukemia: Acute myelogenous leukemia (AML) , Lymphoma, Myelodysplastic Syndrome, Radiation Induced Illness
Additional Keywords : Iatrogenic Disease
Anti Therapeutic Actions : Chemotherapy, Radiotherapy
[+]

There is an increased incidence of myelodysplastic syndrome and acute myeloid leukemia following breast cancer treatment with radiation alone or combined with chemotherapy: a registry cohort analysis 1990-2005.Dec 31, 2010

Pubmed Data : BMC Cancer. 2011 ;11:260. Epub 2011 Jun 21. PMID: 21693006
Article Published Date : Dec 31, 2010
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Chemotherapy and Radiation Toxicity, Leukemia: Acute myelogenous leukemia (AML) , Myelodysplastic Syndromes, Radiotherapy
Anti Therapeutic Actions : Radiotherapy
Adverse Pharmacological Actions : Myelotoxicity, Radiotoxic
[+]

Exposure of NK cells to morphine decreased their ability to induce apoptosis in K562 cells.Oct 14, 2019

Pubmed Data : Brain Behav Immun. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626971
Article Published Date : Oct 14, 2019
Study Type : Human In Vitro
Additional Links
Diseases : Cancers: All, Leukemia: Acute myelogenous leukemia (AML)
Additional Keywords : Increased Risk
Problem Substances : Morphine
[+]

Acute non-lymphocytic leukaemia and myelofibrosis following sequential hemibody irradiation for prostatic carcinoma has been reported.Sep 01, 1991

Pubmed Data : Clin Oncol (R Coll Radiol). 1991 Sep;3(5):288-90. PMID: 1931775
Article Published Date : Sep 01, 1991
Study Type : Human: Case Report
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Myelofibrosis, Prostate Cancer, Radiation Induced Illness
Anti Therapeutic Actions : Radiotherapy
[+]

Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-D-glucan.Jul 14, 2020

Pubmed Data : Carbohydr Polym. 2020 Jul 15 ;240:116329. Epub 2020 Apr 23. PMID: 32475588
Article Published Date : Jul 14, 2020
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

Anti-tumor activity of verbascoside loaded gold nanoparticles.Nov 30, 2014

Pubmed Data : J Biomed Nanotechnol. 2014 Dec ;10(12):3638-46. PMID: 26000377
Article Published Date : Nov 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gold (nanoparticles), Verbascoside
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Curcumin as an epigenetic therapeutic agent in myelodysplastic syndromes.Dec 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Dec 30 ;23(1). Epub 2021 Dec 30. PMID: 35008835
Article Published Date : Dec 29, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Myelodysplastic Syndromes
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Epigenetic Modification In Cancer
[+]

Curcumin sensitizes response to cytarabine in acute myeloid leukemia by regulating intestinal microbiota.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Chemother Pharmacol. 2022 02 ;89(2):243-253. Epub 2022 Jan 23. PMID: 35066694
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Chemosensitizer, Gastrointestinal Agents
Additional Keywords : Chemothapeutic Synergy: Cytarabine
[+]

Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro.Dec 31, 2016

Pubmed Data : Anticancer Drugs. 2017 08 ;28(7):723-738. PMID: 28471807
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Deguelin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Chemotherapeutic
[+]

Diallyl disulfide down-regulates calreticulin and promotes C/EBPα expression in differentiation of human leukaemia cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 01 ;23(1):194-204. Epub 2018 Nov 5. PMID: 30394654
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Garlic, Organosulfur Compounds
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative
[+]

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells. Jul 08, 2008

Pubmed Data : Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID: 18374481
Article Published Date : Jul 08, 2008
Study Type : Animal Study
Additional Links
Substances : Alpinia galanga, Flavonoids
Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemosensitizer
[+]

Ginsenoside Rh2 had good anti-tumor effect in vivo.Jan 31, 2016

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2016 Feb ;41(4):700-704. PMID: 28871696
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Histone deacetylase inhibitor
[+]

Hispolon may have the potential to serve as a therapeutic tool to treat acute myeloid leukemia.Oct 22, 2013

Pubmed Data : J Agric Food Chem. 2013 Oct 23 ;61(42):10063-73. Epub 2013 Oct 15. PMID: 24093560
Article Published Date : Oct 22, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phellinus Linteus
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Rosemary may have therapeutic value in the treatment of acute myeloid leukemia. Jan 01, 2008

Pubmed Data : Oncology. 2008;75(3-4):203-14. Epub 2008 Oct 14. PMID: 18852491
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Rosemary
Diseases : Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antioxidants
[+]

Willow leaf extract contains anti-tumor agents effective against acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in mice. Jan 31, 2007

Pubmed Data : PLoS One. 2007 Jan 31;2(1):e178. PMID: 17264881
Article Published Date : Jan 31, 2007
Study Type : Animal Study
Additional Links
Substances : Willow Bark
Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)
[+]

"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell."Jul 01, 1997

Pubmed Data : Nat Med. 1997 Jul ;3(7):730-7. PMID: 9212098
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Cancer Stem Cells, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative
[+]

Amygdalin (laetrile) is antiproliferative and induces programmed cell death in Acute Myeloid Leukemia. Feb 01, 2003

Pubmed Data : Arch Pharm Res. 2003 Feb;26(2):157-61. PMID: 12643594
Article Published Date : Feb 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Amygdalin
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Myeloid Leukemia: Acute
[+]

Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.Jan 14, 2014

Pubmed Data : Biochem Pharmacol. 2014 Jan 15 ;87(2):229-42. Epub 2013 Oct 24. PMID: 24161787
Article Published Date : Jan 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
[+]

Anti-leukemia effect and mechanism of oridonin on omatinib-sensitive and imatinib-resistant K562 cells.Sep 30, 2017

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Oct ;25(5):1378-1383. PMID: 29070111
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Antileukaemic cell proliferation and cytotoxic activity of edible golden Cordyceps militaris extracts.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:5347718. Epub 2022 Apr 22. PMID: 35497915
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Monocytic
Pharmacological Actions : Antiproliferative
[+]

Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis.Jan 28, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Jan 29. Epub 2020 Jan 29. PMID: 32007276
Article Published Date : Jan 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Artemisinin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis.Apr 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2022 Apr 20 ;13(4):379. Epub 2022 Apr 20. PMID: 35443722
Article Published Date : Apr 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Artesunate with bortezomib shows a significant synergistic effects on proliferation, apoptosis and autophagy of MV4-11 cell lines.Mar 13, 2019

Pubmed Data : Zhonghua Xue Ye Xue Za Zhi. 2019 Mar 14 ;40(3):204-208. PMID: 30929387
Article Published Date : Mar 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Benzene and its metabolites are leukemogenic.May 01, 2010

Pubmed Data : Leukemia. 2010 May;24(5):986-91. Epub 2010 Mar 25. PMID: 20339439
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene, Benzene Metabolites, Hydroquinone
[+]

Biomimetic doxorubicin/ginsenoside co-loading nanosystem for chemoimmunotherapy of acute myeloid leukemia.Jun 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nanobiotechnology. 2022 Jun 14 ;20(1):273. Epub 2022 Jun 14. PMID: 35701846
Article Published Date : Jun 13, 2022
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Black hellebore (Helleborus niger) induces programmed cell death in the Actue lymphoblastic leukemia (ALL) cells and Acute myeloid leukemia (AML). Apr 01, 2009

Pubmed Data : Pediatr Blood Cancer. 2009 Apr;52(4):464-9. PMID: 19090543
Article Published Date : Apr 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Black hellebore
Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic
[+]

Camptothecin acts synergistically with imatinib and overcomes imatinib resistance in chronic myelogenous leukemia (CML) cells.Jul 08, 2007

Pubmed Data : Cancer Lett. 2007 Jul 8;252(1):75-85. Epub 2007 Jan 16. PMID: 17223257
Article Published Date : Jul 08, 2007
Study Type : In Vitro Study
Additional Links
Substances : Camptothecin
Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Clove mistletoe had a potent natural anticancer activity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharmacol Sci. 2016 ;2016:3242698. Epub 2016 Mar 23. PMID: 27099614
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Animal Cancers, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Cytotoxic
Additional Keywords : Plant Extracts
[+]

Co-treatment likely assists in enhancing the cytotoxic effects of Dox by inhibiting the cell proliferation activity of AML leukemic stem cells.Sep 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Sep 24 ;26(19). Epub 2021 Sep 24. PMID: 34641328
Article Published Date : Sep 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Combined Effects of Tanshinone IIA and an autophagy inhibitor on the apoptosis of leukemia cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2022 Jan-Dec;21:15347354221117776. PMID: 35996358
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Creeping daisy extract has apoptotic and anti-leukemia activity in MEG-01 cells. Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr J Tradit Complement Altern Med. 2017 ;14(3):167-174. Epub 2017 Mar 1. PMID: 28480428
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Daisy
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines.Dec 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Biol Ther. 2022 Dec 31 ;23(1):328-335. PMID: 35435150
Article Published Date : Dec 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic
[+]

Curcumin induces programmed cell death and disturbs cell cycle progression in leukemia cells.Jan 01, 2002

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2002;22(4):295-8. PMID: 12674762
Article Published Date : Jan 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Promyelocytic leukemia
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Diallyl disulfide can inhibit the K562 cell proliferation.May 31, 2018

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun ;26(3):750-755. PMID: 29950215
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Organosulfur Compounds
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Diosmetin induces apoptosis of acute myeloid leukemia cells.Jan 04, 2018

Pubmed Data : Mol Pharm. 2018 03 5 ;15(3):1353-1360. Epub 2018 Feb 7. PMID: 29412683
Article Published Date : Jan 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Diosmetin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Estrogen Receptor Beta
[+]

Effects of cultivated Cordyceps sinensis on proliferation and apoptosis of human leukemia K562 cells.Apr 30, 2018

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 May ;43(10):2134-2139. PMID: 29933683
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis.Sep 29, 2020

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2020 Sep 30 ;40(9):1230-1238. PMID: 32990229
Article Published Date : Sep 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro - Article 2. Jun 01, 2005

Pubmed Data : Blood. 2005 Jun 1;105(11):4163-9. Epub 2005 Feb 1. PMID: 15687234
Article Published Date : Jun 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Apoptotic, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro. Sep 01, 2005

Pubmed Data : Expert Opin Biol Ther. 2005 Sep;5(9):1147-52. PMID: 16120045
Article Published Date : Sep 01, 2005
Study Type : Commentary
Additional Links
Substances : Feverfew
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.Dec 15, 2007

Pubmed Data : Blood. 2007 Dec 15;110(13):4427-35. Epub 2007 Sep 5. PMID: 17804695
Article Published Date : Dec 15, 2007
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Selective Cytotoxicity
[+]

Garlic contains a compound known as ajoene which may be therapeutic in multi-drug resistant AML patients. Jul 01, 2004

Pubmed Data : Leuk Res. 2004 Jul;28(7):667-71. PMID: 15158086
Article Published Date : Jul 01, 2004
Study Type : Review
Additional Links
Substances : Garlic
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Additional Keywords : Multi-Drug Resistant Cancers
[+]

Ginsenoside 20(S)-Rh2 induces apoptosis and differentiation of acute myeloid leukemia cells.Sep 05, 2017

Pubmed Data : J Agric Food Chem. 2017 Sep 6 ;65(35):7687-7697. Epub 2017 Aug 23. PMID: 28793767
Article Published Date : Sep 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Ginsenoside Rh2 induces apoptosis and autophagy of K562 cells by activating p38.Dec 31, 2016

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2017 Jan ;42(1):146-151. PMID: 28945040
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Ginsenoside Rh2 inhibits proliferation and promotes apoptosis of leukemia KG1-α cells.May 31, 2014

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jun ;30(6):565-8. PMID: 24909273
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Gleditsia sinensis might be potentially used as a chemotherapeutic drug to treat patients with acute and chronic myelogenous leukemia.Sep 01, 2003

Pubmed Data : Oncol Rep. 2003 Sep-Oct;10(5):1601-7. PMID: 12883747
Article Published Date : Sep 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Gleditsia sinensis
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

High dose vitamin C can inhibit the proliferation and promote the apoptosis of acute myeloid leukemia cells.May 31, 2020

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Jun ;28(3):833-841. PMID: 32552944
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Selective Cytotoxicity
[+]

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells.May 31, 2017

Pubmed Data : Tumour Biol. 2017 Jun ;39(6):1010428317705768. PMID: 28631564
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Telomerase Inhibitor
[+]

Induction of apoptosis by piceatannol in human leukemic U937 cells.Mar 31, 2008

Pubmed Data : Oncol Rep. 2008 Apr ;19(4):961-7. PMID: 18357382
Article Published Date : Mar 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
[+]

Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells.Nov 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Nov 26 ;8(1):17377. Epub 2018 Nov 26. PMID: 30478296
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Isoalantolactone significantly inhibits K562/A02 cell proliferation mainly via caspase-dependent apoptotic pathway.Jan 31, 2017

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb ;25(1):110-114. PMID: 28245385
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Mangiferin inhibits MV4-11 cell proliferation, arrests cell cycle progression and promotes apoptosis.Mar 31, 2019

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr ;27(2):385-389. PMID: 30998142
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

miR-497 plays a key role in Tanshinone IIA-attenuated proliferation in OCI-AML3 cells via the MAPK/ERK1/2 pathway.Mar 10, 2020

Pubmed Data : Cytotechnology. 2020 Mar 11. Epub 2020 Mar 11. PMID: 32162175
Article Published Date : Mar 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Myricetin exhibits potent anti-leukemia activity by interfering with purine nucleotides biosynthetic pathway.Jan 01, 2016

Pubmed Data : Biochem Biophys Res Commun. 2016 09 2 ;477(4):915-922. Epub 2016 Jul 1. PMID: 27378425
Article Published Date : Jan 01, 2016
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Nobiletin inhibited HL-60 cell proliferation through inducing cell-cycle arrest and apoptosis and could serve as a potential additional chemotherapeutic agent for treating AML.Nov 30, 2014

Pubmed Data : Tumour Biol. 2014 Dec ;35(12):11903-11. Epub 2014 Aug 28. PMID: 25164609
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, P38 Mitogen-Activated Protein Kinase Modulator
[+]

Olive leaf extract inhibits growth and differentiation of human promyelocytic leukemia cells. May 01, 2007

Pubmed Data : Biosci Biotechnol Biochem. 2007 May;71(5):1306-12. Epub 2007 May 7. PMID: 17485840
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Olive leaf extract
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Promyelocytic leukemia
[+]

Parthenolide or piperlongumine that induce almost complete glutathione depletion and severe cell death in AML cells.Nov 21, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2013 Nov 22 ;288(47):33542-58. Epub 2013 Oct 2. PMID: 24089526
Article Published Date : Nov 21, 2013
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide, Piperlongumine
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Oxidative Stress
Pharmacological Actions : Cytotoxic
[+]

Piceatannol suppresses TNF-α shedding in U937 cells.Aug 31, 2012

Pubmed Data : Biochem Pharmacol. 2012 Sep 1 ;84(5):670-80. Epub 2012 Jun 15. PMID: 22705645
Article Published Date : Aug 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Puerarin can selectively inhibit the proliferation of 4 AML cell lines.Mar 31, 2010

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Apr ;18(2):296-9. PMID: 20416155
Article Published Date : Mar 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Selective Antiproliferation
[+]

Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing autophagy.Nov 02, 2020

Pubmed Data : Phytother Res. 2020 Nov 3. Epub 2020 Nov 3. PMID: 33141989
Article Published Date : Nov 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Autophagy Up-regulation, Chemosensitizer
[+]

Recent progress of oridonin and its derivatives for the treatment of acute myelogenous leukemia.Dec 31, 2019

Pubmed Data : Mini Rev Med Chem. 2020 ;20(6):483-497. PMID: 31660811
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Oridonin
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Chemotherapeutic
[+]

Restoration of TET2 function blocks aberrant self-renewal and leukemia progression.Sep 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell. 2017 Sep 7 ;170(6):1079-1095.e20. Epub 2017 Aug 17. PMID: 28823558
Article Published Date : Sep 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Chemotherapeutic
[+]

Resveratrol inhibits proliferation and induces differentiation of myeloid leukemia cells.Jun 01, 2002

Pubmed Data : Int J Hematol. 2002 Jun;75(5):528-33. PMID: 12095155
Article Published Date : Jun 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Drug-Plant-Vitamin Synergies, Stilbenes
[+]

Resveratrol reverses doxorubicin resistance in acute myeloid leukemia cells.Jan 01, 2008

Pubmed Data : Environ Health. 2008;7:21. Epub 2008 May 30. PMID: 20350534
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Stilbenes
[+]

Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells.Dec 31, 2018

Pubmed Data : Bioorg Chem. 2019 05 ;86:363-367. Epub 2019 Jan 31. PMID: 30753990
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Sonchus oleraceus and juniper extracts had anti-tumor effects.Jun 04, 2016

Pubmed Data : J Ethnopharmacol. 2016 Jun 5 ;185:289-99. Epub 2016 Mar 19. PMID: 27001625
Article Published Date : Jun 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Juniper, Thistle
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
[+]

Sulforaphane induces leukemia cells to block in G2/M phase by activating P53 signaling pathway.Jul 31, 2021

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Aug ;29(4):1050-1055. PMID: 34362481
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway.Mar 14, 2022

Pubmed Data : Eur J Pharmacol. 2022 Mar 15 ;919:174824. Epub 2022 Feb 11. PMID: 35157913
Article Published Date : Mar 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Supercritical extracts of aloe vera exhibit antitumor properties and modulate antioxidant enzymes. Nov 24, 2009

Pubmed Data : Curr Med Chem. 2009 Nov 24. Epub 2009 Nov 24. PMID: 19941474
Article Published Date : Nov 24, 2009
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Acute lymphoblastic leukemia (ALL), Colon Cancer, Leukemia: Acute myelogenous leukemia (AML) , Tumors
Pharmacological Actions : Anti-Tumor
Additional Keywords : Selective Cytotoxicity
[+]

Suppressing crucial oncogenes of leukemia initiator cells by major royal jelly protein 2 for mediating apoptosis in myeloid and lymphoid leukemia cells.Aug 29, 2022

Pubmed Data : Food Funct. 2022 Aug 30 ;13(17):8951-8966. Epub 2022 Aug 30. PMID: 35929786
Article Published Date : Aug 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Royal Jelly
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Oncogene Suppressor
[+]

Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis.Oct 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Nov ;95:477-486. Epub 2017 Sep 12. PMID: 28865368
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Honeysuckle
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2020 ;20:379. Epub 2020 Aug 7. PMID: 32782437
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.Aug 01, 2010

Pubmed Data : Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Carsonic Acid, Curcumin, Milk Thistle, Silibinin
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Oxidative Stress
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance Synergy, Plant Extracts
[+]

Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.Jul 02, 2010

Pubmed Data : Curr Mol Pharmacol. 2010 Jul 2. Epub 2010 Jul 2. PMID: 20594187
Article Published Date : Jul 02, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic Lymphocytic Leukemia (CLL), Leukemia: Chronic myelogenous leukemia (CML) , Multiple Myeloma, Myelodysplastic Syndrome
Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor
[+]

V. album extract increases antileukemic effectiveness of doxorubicin against resistant K562 cells.Feb 29, 2016

Pubmed Data : Phytother Res. 2016 Mar ;30(3):485-95. Epub 2015 Dec 21. PMID: 26692465
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Plant Extracts
[+]

Wogonin, a compound found within Chinese Skullcap, significantly suppresses differentiation of leukemia cells in acute myeloid leukemia.Apr 01, 2008

Pubmed Data : Cancer Sci. 2008 Apr;99(4):689-95. PMID: 18377421
Article Published Date : Apr 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap
Diseases : Acute Myeloid Leukemia, Leukemia: Acute myelogenous leukemia (AML)
[+]

γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines.Nov 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 17 ;11(11). Epub 2019 Nov 17. PMID: 31744219
Article Published Date : Nov 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma, Vitamin E
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

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