Leukemia: Chronic myelogenous leukemia (CML)

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38 Substances Researched for Leukemia: Chronic myelogenous leukemia (CML)
NameACCKFocus
Curcumin717Locked
Turmeric110Locked
Resveratrol77Locked
Amurensin G15Locked
D-Limonene34Locked
Tripterygium wilfordii23Locked
Wogonin23Locked
Alpinia galanga12Locked
Flavonoids12Locked
Stilbenes22Locked
Tanshinone IIA22Locked
Bai Zhu11Locked
Bee Venom11Locked
Betulinic acid11Locked
Bufalin11Locked
Cleavers11Locked
Crocin11Locked
Cucurbitacin B 11Locked
EGCG (Epigallocatechin gallate)11Locked
Emodin11Locked
Fermented Foods and Beverages11Locked
Ginseng (Korean)11Locked
Ginsenosides11Locked
Gleditsia sinensis11Locked
Isothiocyanates11Locked
Kefir11Locked
Lactobacillus casei11Locked
Nobiletin 11Locked
Puerarin11Locked
Quercetin11Locked
Rice Bran11Locked
Seaweed11Locked
Triptolide11Locked
Ursolic Acid11Locked
Wasabi11Locked
White Clover11Locked
Xanthohumol11Locked
Zerumbone11Locked
Related Topics

Leukemia: Chronic myelogenous leukemia (CML) is a Sub of the following Topic

View the Evidence:
51 Abstracts with Leukemia: Chronic myelogenous leukemia (CML) Research

[+]

Curcumin acts as an adjuvant to imatinib in decreasing the NO levels and may help in the treatment of CML patients.Aug 15, 2011

Pubmed Data : J Oncol Pharm Pract. 2011 Aug 15. Epub 2011 Aug 15. PMID: 21844132
Article Published Date : Aug 15, 2011
Study Type : Human Study
Additional Links
Substances : Curcumin, Turmeric
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Nitric Oxide Inhibitor
Additional Keywords : Drug: Imatinib, Drug Synergy
[+]

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Pubmed Data : Biochem Pharmacol. 2012 Aug 1 ;84(3):402-10. Epub 2012 Mar 29. PMID: 22483777
Article Published Date : Jul 31, 2012
Study Type : Human In Vitro
Additional Links
Substances : Amurensin G
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Cancer Stem Cells, Gene Expression Regulation, Natural Substance Synergy
[+]

Curcumin treated animals had a significant reduction in tumor growth as measured by the decrease in size of the subcutaneous xenografts compared to untreated animals.Jun 07, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Jun 8. Epub 2015 Jun 8. PMID: 26116834
Article Published Date : Jun 07, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Exosomes
[+]

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells. Jul 08, 2008

Pubmed Data : Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID: 18374481
Article Published Date : Jul 08, 2008
Study Type : Animal Study
Additional Links
Substances : Alpinia galanga, Flavonoids
Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemosensitizer
[+]

These studies suggest promising anti-leukemic and anti-angiogenic effects of d-Limonene in the treatment of chronic myeloid leukemia.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Animal Model Exp Med. 2018 Dec ;1(4):328-333. Epub 2018 Nov 21. PMID: 30891583
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Angiogenesis Inhibitors
[+]

Triptolide, a constituent of Tripterygium wilfordii, induces programmed cell death in drug-resistant chronic myelogenous leukemia cells. Mar 01, 2009

Pubmed Data : Clin Cancer Res. 2009 Mar 1;15(5):1686-97. Epub 2009 Feb 24. PMID: 19240172
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in U937 and K562 cells.Mar 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Mar 8 ;10(3). Epub 2018 Mar 8. PMID: 29518056
Article Published Date : Mar 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Acute Myeloid Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

A fermentation extract derived from rice bran and seaweed extract inhibits breast cancer and chronic myelogenous leukemia (CML) cell line growth. Nov 01, 2004

Pubmed Data : Int J Mol Med. 2004 Nov;14(5):925-9. PMID: 15492867
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Rice Bran, Seaweed
Diseases : Breast Cancer, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

A natural compound from Wasabia japonica inhibited the viability of human chronic myelogenous leukemia K562 cells.Nov 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 23 ;9(12). Epub 2019 Nov 23. PMID: 31771225
Article Published Date : Nov 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Wasabi
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation, Cell cycle arrest
[+]

Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib.Aug 31, 2013

Pubmed Data : Apoptosis. 2013 Sep ;18(9):1060-70. PMID: 23613107
Article Published Date : Aug 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Atractylenolide I could be used for leukemia treatment in the future.Apr 14, 2016

Pubmed Data : Bioorg Med Chem Lett. 2016 Apr 15 ;26(8):1905-9. Epub 2016 Mar 8. PMID: 26988300
Article Published Date : Apr 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bai Zhu
Diseases : Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Betulinic acid induces programmed cell death in human chronic myelogenous leukemia (CML) cells. Mar 15, 2005

Pubmed Data : Toxicol Lett. 2005 Mar 15;155(3):343-51. PMID: 15649617
Article Published Date : Mar 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Compounds from cleavers could inhibit the proliferative activity of leukemia K562 cells.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2016 May ;24(3):241-4. Epub 2016 Apr 24. PMID: 27275108
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cleavers
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
Additional Keywords : Dose Response, Plant Extracts
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Cucurbitacin B induced DNA damage, G2/M arrest, and apoptosis in K562 cells.Dec 31, 2013

Pubmed Data : Anticancer Agents Med Chem. 2014 ;14(8):1146-53. PMID: 24893803
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Curcumin inhibits chronic myelogenous leukemia cells (K562).Nov 01, 2007

Pubmed Data : J Altern Complement Med. 2007 Nov;13(9):985-7. PMID: 15182583
Article Published Date : Nov 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
[+]

Curcumin may have therapeutic value in chronic myelocytic leukemia (CML). Oct 01, 2004

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):572-6. PMID: 15498113
Article Published Date : Oct 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
[+]

Curcumin may have therapeutic value in treating human chronic myelogenous leukemia due to its ability to regulate NF-kappB genes and pathways.Aug 01, 2009

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:436-47. PMID: 19723087
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Interleukin-10 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin modulates chronic myelogenous leukemia exosomes compositionMar 29, 2016

Pubmed Data : Oncotarget. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27050372
Article Published Date : Mar 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Anti-Angiogenic, MicroRNA modulator
[+]

Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells.Jan 01, 2007

Pubmed Data : Acta Pharmacol Sin. 2007 Jan;28(1):105-10. PMID: 17184589
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Drug Synergy
[+]

D-limonene can inhibit proliferation of K562 cells in dose-dependent manner.Nov 30, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec ;14(6):1120-2. PMID: 17204176
Article Published Date : Nov 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Effects of D-limonene on leukemia cells HL-60 and K562 in vitroJul 31, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Aug ;14(4):692-5. PMID: 16928301
Article Published Date : Jul 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML) , Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

EGCG has anti-leukemia activity and enhances imatinib-induced cell death. Feb 01, 2009

Pubmed Data : Cancer Sci. 2009 Feb;100(2):349-56. PMID: 19200260
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Emodin and AZT synergistically inhibit the proliferation and induce apoptosis of leukemia K562 cells.Dec 31, 2019

Pubmed Data : Oncol Rep. 2020 Jan ;43(1):260-269. Epub 2019 Nov 19. PMID: 31746437
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Farnesiferol C induces apoptosis in chronic myelogenous leukemia cells as an imatinib sensitizer.Nov 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Nov 6 ;20(22). Epub 2019 Nov 6. PMID: 31698777
Article Published Date : Nov 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asafoetida
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Gleditsia sinensis might be potentially used as a chemotherapeutic drug to treat patients with acute and chronic myelogenous leukemia.Sep 01, 2003

Pubmed Data : Oncol Rep. 2003 Sep-Oct;10(5):1601-7. PMID: 12883747
Article Published Date : Sep 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Gleditsia sinensis
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Hydroxychavicol sensitizes imatinib-resistant chronic myelogenous leukemia cells to TRAIL-induced apoptosis.Dec 31, 2018

Pubmed Data : Anticancer Drugs. 2019 02 ;30(2):167-178. PMID: 30418193
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betel, Polyphenols
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Imatinib mesylate and resveratrol are potent drug treatments for human chronic myelogenous leukemia, offering a promising means of inhibiting cell growth and apoptosis.Dec 31, 2014

Pubmed Data : Genet Mol Res. 2015 ;14(2):6413-8. Epub 2015 Jun 11. PMID: 26125846
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response, Drug: Imatinib
[+]

Korean red ginseng extract can enhance the anticancer activity of imatinib mesylate and may have a substantial potential in the treatment of chronic myelogenous leukemia.Apr 07, 2015

Pubmed Data : Phytother Res. 2015 Apr 8. Epub 2015 Apr 8. PMID: 25857479
Article Published Date : Apr 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Melittin-a natural peptide from bee venom which induces apoptosis in human leukaemia cells. Feb 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Feb 6 ;10(2). Epub 2020 Feb 6. PMID: 32041197
Article Published Date : Feb 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Acute lymphoblastic leukemia (ALL), Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Nobiletin may serve as a beneficial anti-leukemic agent for differentiation therapy.Apr 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 Apr 3 ;9(4). Epub 2020 Apr 3. PMID: 32260160
Article Published Date : Apr 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Chronic Myeloid Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells.Oct 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2022 Oct 8 ;301:115815. Epub 2022 Oct 8. PMID: 36220508
Article Published Date : Oct 07, 2022
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Puerarin increases the cell apoptosis through induction of autophagic apoptosis of K562 cells.Oct 31, 2017

Pubmed Data : J BUON. 2017 Nov-Dec;22(6):1554-1562. PMID: 29332352
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Dose Response
[+]

Quercetin can inhibit the proliferation K562 and K562R cells.Sep 30, 2019

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Oct ;27(5):1409-1415. PMID: 31607291
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Chemosensitizer, Wnt/β-catenin signaling pathway modulation
[+]

Resveratrol has chemotherapeutic potential in treating chronic myelogenous leukemia.Jan 01, 2010

Pubmed Data : PLoS One. 2010;5(1):e8719. Epub 2010 Jan 14. PMID: 20090934
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Drug Synergy
[+]

Resveratrol induces apoptosis in chronic myelogenous leukemia cells. Jun 01, 2008

Pubmed Data : Cancer Sci. 2008 Jun;99(6):1109-16. Epub 2008 Apr 21. PMID: 18429957
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Resveratrol induces apoptosis in Imatinib-resistant chronic myelogenous leukemia cells. Jun 01, 2008

Pubmed Data : FASEB J. 2008 Jun;22(6):1894-904. Epub 2008 Feb 1. PMID: 18245170
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Resveratrol is a blocker of STAT5 activation and thus may be potentially useful for the treatment of chronic myelogenous leukemia.Jun 05, 2018

Pubmed Data : Anticancer Drugs. 2018 Jun 6. Epub 2018 Jun 6. PMID: 29878900
Article Published Date : Jun 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemotherapeutic
[+]

Resveratrol may have anti-chronic myelogenous leukemia activity. Jul 21, 2010

Pubmed Data : Autophagy. 2010 Jul 21;6(5). Epub 2010 Jul 21. PMID: 20458181
Article Published Date : Jul 21, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
[+]

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells.Feb 01, 2010

Pubmed Data : Cancer Res. 2010 Feb 1;70(3):1042-52. Epub 2010 Jan 26. PMID: 20103647
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Autophagy Up-regulation, C-Jun N-Terminal Kinases (JNK) Modulator
[+]

Tanshinone IIA can inhibit the proliferation of K562 cells.Apr 30, 2014

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 May ;45(3):410-3. PMID: 24941807
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Tanshinone IIA induces autophagic cell death in KBM-5 leukemia cells.Feb 28, 2014

Pubmed Data : Phytother Res. 2014 Mar ;28(3):458-64. Epub 2013 Jun 27. PMID: 23813779
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

The results suggest that the six lactic acid bacteria mixture from kefir has strong effects on natural immunity and tumor cell cytotoxicity.Mar 26, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2018 Mar 27 ;7(4). Epub 2018 Mar 27. PMID: 29584690
Article Published Date : Mar 26, 2018
Study Type : In Vitro Study
Additional Links
Substances : Kefir
Diseases : Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Immunomodulatory
[+]

The study of extracellular protein fractions of probiotic candidate bacteria on cancerous cell line.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Iran Med. 2016 Nov ;19(11):779-785. PMID: 27845547
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus casei
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These results suggest bufalin can reverse drug resistance in K562/A02 cells.Apr 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Apr 7 ;25:2542-2552. Epub 2019 Apr 7. PMID: 30955024
Article Published Date : Apr 06, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bufalin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

This study provided a novel mechanism for the anti-leukemia effect of ursolic acid on K562 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:33358. Epub 2016 Sep 16. PMID: 27634378
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Trifolium repens blocks proliferation in chronic myelogenous leukemia.Feb 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 Feb 6 ;9(2). Epub 2020 Feb 6. PMID: 32041350
Article Published Date : Feb 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : White Clover
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
[+]

Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.Jul 02, 2010

Pubmed Data : Curr Mol Pharmacol. 2010 Jul 2. Epub 2010 Jul 2. PMID: 20594187
Article Published Date : Jul 02, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic Lymphocytic Leukemia (CLL), Leukemia: Chronic myelogenous leukemia (CML) , Multiple Myeloma, Myelodysplastic Syndrome
Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor
[+]

Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Sep ;8(17):1046. PMID: 33145265
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Xanthohumol induces caspase-dependent degradation of oncoprotein BCR-ABL in K562 cells.Sep 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Sep 16 ;8(9). Epub 2019 Sep 16. PMID: 31527518
Article Published Date : Sep 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Oncoprotein BCR-ABL
[+]

Zerumbone induces mitochondria-mediated apoptosis in K562 chronic myelogenous leukemia cells.Oct 31, 2015

Pubmed Data : Tumour Biol. 2015 Nov ;36(11):8479-89. Epub 2015 May 31. PMID: 26026585
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic

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