Leukemia: Chronic myelogenous leukemia (CML)

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45 Substances Researched for Leukemia: Chronic myelogenous leukemia (CML)
NameACCKFocus
Curcumin717Locked
Turmeric110Locked
Resveratrol77Locked
Amurensin G15Locked
D-Limonene34Locked
Tripterygium wilfordii23Locked
Alpinia galanga12Locked
Flavonoids12Locked
Stilbenes22Locked
Tanshinone IIA22Locked
Asafoetida11Locked
Bai Zhu11Locked
Bee Venom11Locked
Betel11Locked
Betulinic acid11Locked
Bufalin11Locked
Cleavers11Locked
Crocin11Locked
Cucurbitacin B 11Locked
EGCG (Epigallocatechin gallate)11Locked
Elecampane11Locked
Emodin11Locked
Fermented Foods and Beverages11Locked
Ginseng (Korean)11Locked
Ginsenosides11Locked
Gleditsia sinensis11Locked
Isothiocyanates11Locked
Kefir11Locked
Lactobacillus casei11Locked
Medicinal Mushrooms11Locked
Mushrooms: All 11Locked
Nobiletin 11Locked
Piperlongumine 11Locked
Polyphenols11Locked
Puerarin11Locked
Quercetin11Locked
Rice Bran11Locked
Seaweed11Locked
Triptolide11Locked
Ursolic Acid11Locked
Wasabi11Locked
White Clover11Locked
Wogonin11Locked
Xanthohumol11Locked
Zerumbone11Locked
Related Topics

Leukemia: Chronic myelogenous leukemia (CML) is a Sub of the following Topic

View the Evidence:
52 Abstracts with Leukemia: Chronic myelogenous leukemia (CML) Research

[+]

Curcumin acts as an adjuvant to imatinib in decreasing the NO levels and may help in the treatment of CML patients.Aug 15, 2011

Pubmed Data : J Oncol Pharm Pract. 2011 Aug 15. Epub 2011 Aug 15. PMID: 21844132
Article Published Date : Aug 15, 2011
Study Type : Human Study
Additional Links
Substances : Curcumin, Turmeric
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Nitric Oxide Inhibitor
Additional Keywords : Drug: Imatinib, Drug Synergy
[+]

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Pubmed Data : Biochem Pharmacol. 2012 Aug 1 ;84(3):402-10. Epub 2012 Mar 29. PMID: 22483777
Article Published Date : Jul 31, 2012
Study Type : Human In Vitro
Additional Links
Substances : Amurensin G
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Cancer Stem Cells, Gene Expression Regulation, Natural Substance Synergy
[+]

Curcumin treated animals had a significant reduction in tumor growth as measured by the decrease in size of the subcutaneous xenografts compared to untreated animals.Jun 07, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Jun 8. Epub 2015 Jun 8. PMID: 26116834
Article Published Date : Jun 07, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Exosomes
[+]

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells. Jul 08, 2008

Pubmed Data : Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID: 18374481
Article Published Date : Jul 08, 2008
Study Type : Animal Study
Additional Links
Substances : Alpinia galanga, Flavonoids
Diseases : Cancers: Drug Resistant, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemosensitizer
[+]

These studies suggest promising anti-leukemic and anti-angiogenic effects of d-Limonene in the treatment of chronic myeloid leukemia.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Animal Model Exp Med. 2018 Dec ;1(4):328-333. Epub 2018 Nov 21. PMID: 30891583
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Angiogenesis Inhibitors
[+]

Triptolide, a constituent of Tripterygium wilfordii, induces programmed cell death in drug-resistant chronic myelogenous leukemia cells. Mar 01, 2009

Pubmed Data : Clin Cancer Res. 2009 Mar 1;15(5):1686-97. Epub 2009 Feb 24. PMID: 19240172
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in U937 and K562 cells.Mar 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Mar 8 ;10(3). Epub 2018 Mar 8. PMID: 29518056
Article Published Date : Mar 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Acute Myeloid Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

A fermentation extract derived from rice bran and seaweed extract inhibits breast cancer and chronic myelogenous leukemia (CML) cell line growth. Nov 01, 2004

Pubmed Data : Int J Mol Med. 2004 Nov;14(5):925-9. PMID: 15492867
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Rice Bran, Seaweed
Diseases : Breast Cancer, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

A King Bolete, Boletus edulis, RNA fraction Stimulates proliferation and cytotoxicity of natural killer cells against myelogenous leukemia cells.Dec 31, 2016

Pubmed Data : Int J Med Mushrooms. 2017 ;19(4):347-353. PMID: 28605323
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms, Mushrooms: All
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

A natural compound from Wasabia japonica inhibited the viability of human chronic myelogenous leukemia K562 cells.Nov 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 23 ;9(12). Epub 2019 Nov 23. PMID: 31771225
Article Published Date : Nov 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Wasabi
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation, Cell cycle arrest
[+]

Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib.Aug 31, 2013

Pubmed Data : Apoptosis. 2013 Sep ;18(9):1060-70. PMID: 23613107
Article Published Date : Aug 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Atractylenolide I could be used for leukemia treatment in the future.Apr 14, 2016

Pubmed Data : Bioorg Med Chem Lett. 2016 Apr 15 ;26(8):1905-9. Epub 2016 Mar 8. PMID: 26988300
Article Published Date : Apr 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bai Zhu
Diseases : Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Betulinic acid induces programmed cell death in human chronic myelogenous leukemia (CML) cells. Mar 15, 2005

Pubmed Data : Toxicol Lett. 2005 Mar 15;155(3):343-51. PMID: 15649617
Article Published Date : Mar 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Compounds from cleavers could inhibit the proliferative activity of leukemia K562 cells.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2016 May ;24(3):241-4. Epub 2016 Apr 24. PMID: 27275108
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cleavers
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
Additional Keywords : Dose Response, Plant Extracts
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Cucurbitacin B induced DNA damage, G2/M arrest, and apoptosis in K562 cells.Dec 31, 2013

Pubmed Data : Anticancer Agents Med Chem. 2014 ;14(8):1146-53. PMID: 24893803
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Curcumin inhibits chronic myelogenous leukemia cells (K562).Nov 01, 2007

Pubmed Data : J Altern Complement Med. 2007 Nov;13(9):985-7. PMID: 15182583
Article Published Date : Nov 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
[+]

Curcumin may have therapeutic value in chronic myelocytic leukemia (CML). Oct 01, 2004

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):572-6. PMID: 15498113
Article Published Date : Oct 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
[+]

Curcumin may have therapeutic value in treating human chronic myelogenous leukemia due to its ability to regulate NF-kappB genes and pathways.Aug 01, 2009

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:436-47. PMID: 19723087
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Interleukin-10 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin modulates chronic myelogenous leukemia exosomes compositionMar 29, 2016

Pubmed Data : Oncotarget. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27050372
Article Published Date : Mar 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Anti-Angiogenic, MicroRNA modulator
[+]

Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells.Jan 01, 2007

Pubmed Data : Acta Pharmacol Sin. 2007 Jan;28(1):105-10. PMID: 17184589
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Drug Synergy
[+]

D-limonene can inhibit proliferation of K562 cells in dose-dependent manner.Nov 30, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec ;14(6):1120-2. PMID: 17204176
Article Published Date : Nov 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Effects of D-limonene on leukemia cells HL-60 and K562 in vitroJul 31, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Aug ;14(4):692-5. PMID: 16928301
Article Published Date : Jul 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML) , Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

EGCG has anti-leukemia activity and enhances imatinib-induced cell death. Feb 01, 2009

Pubmed Data : Cancer Sci. 2009 Feb;100(2):349-56. PMID: 19200260
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Emodin and AZT synergistically inhibit the proliferation and induce apoptosis of leukemia K562 cells.Dec 31, 2019

Pubmed Data : Oncol Rep. 2020 Jan ;43(1):260-269. Epub 2019 Nov 19. PMID: 31746437
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Farnesiferol C induces apoptosis in chronic myelogenous leukemia cells as an imatinib sensitizer.Nov 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Nov 6 ;20(22). Epub 2019 Nov 6. PMID: 31698777
Article Published Date : Nov 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asafoetida
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Gleditsia sinensis might be potentially used as a chemotherapeutic drug to treat patients with acute and chronic myelogenous leukemia.Sep 01, 2003

Pubmed Data : Oncol Rep. 2003 Sep-Oct;10(5):1601-7. PMID: 12883747
Article Published Date : Sep 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Gleditsia sinensis
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Hydroxychavicol sensitizes imatinib-resistant chronic myelogenous leukemia cells to TRAIL-induced apoptosis.Dec 31, 2018

Pubmed Data : Anticancer Drugs. 2019 02 ;30(2):167-178. PMID: 30418193
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betel, Polyphenols
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Imatinib mesylate and resveratrol are potent drug treatments for human chronic myelogenous leukemia, offering a promising means of inhibiting cell growth and apoptosis.Dec 31, 2014

Pubmed Data : Genet Mol Res. 2015 ;14(2):6413-8. Epub 2015 Jun 11. PMID: 26125846
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response, Drug: Imatinib
[+]

Korean red ginseng extract can enhance the anticancer activity of imatinib mesylate and may have a substantial potential in the treatment of chronic myelogenous leukemia.Apr 07, 2015

Pubmed Data : Phytother Res. 2015 Apr 8. Epub 2015 Apr 8. PMID: 25857479
Article Published Date : Apr 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Melittin-a natural peptide from bee venom which induces apoptosis in human leukaemia cells. Feb 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Feb 6 ;10(2). Epub 2020 Feb 6. PMID: 32041197
Article Published Date : Feb 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Acute lymphoblastic leukemia (ALL), Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Nobiletin may serve as a beneficial anti-leukemic agent for differentiation therapy.Apr 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 Apr 3 ;9(4). Epub 2020 Apr 3. PMID: 32260160
Article Published Date : Apr 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Chronic Myeloid Leukemia, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells.Oct 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2022 Oct 8 ;301:115815. Epub 2022 Oct 8. PMID: 36220508
Article Published Date : Oct 07, 2022
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Puerarin increases the cell apoptosis through induction of autophagic apoptosis of K562 cells.Oct 31, 2017

Pubmed Data : J BUON. 2017 Nov-Dec;22(6):1554-1562. PMID: 29332352
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Dose Response
[+]

Quercetin can inhibit the proliferation K562 and K562R cells.Sep 30, 2019

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Oct ;27(5):1409-1415. PMID: 31607291
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Chemosensitizer, Wnt/β-catenin signaling pathway modulation
[+]

Resveratrol has chemotherapeutic potential in treating chronic myelogenous leukemia.Jan 01, 2010

Pubmed Data : PLoS One. 2010;5(1):e8719. Epub 2010 Jan 14. PMID: 20090934
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Drug Synergy
[+]

Resveratrol induces apoptosis in chronic myelogenous leukemia cells. Jun 01, 2008

Pubmed Data : Cancer Sci. 2008 Jun;99(6):1109-16. Epub 2008 Apr 21. PMID: 18429957
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Resveratrol induces apoptosis in Imatinib-resistant chronic myelogenous leukemia cells. Jun 01, 2008

Pubmed Data : FASEB J. 2008 Jun;22(6):1894-904. Epub 2008 Feb 1. PMID: 18245170
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Resveratrol is a blocker of STAT5 activation and thus may be potentially useful for the treatment of chronic myelogenous leukemia.Jun 05, 2018

Pubmed Data : Anticancer Drugs. 2018 Jun 6. Epub 2018 Jun 6. PMID: 29878900
Article Published Date : Jun 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemotherapeutic
[+]

Resveratrol may have anti-chronic myelogenous leukemia activity. Jul 21, 2010

Pubmed Data : Autophagy. 2010 Jul 21;6(5). Epub 2010 Jul 21. PMID: 20458181
Article Published Date : Jul 21, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
[+]

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells.Feb 01, 2010

Pubmed Data : Cancer Res. 2010 Feb 1;70(3):1042-52. Epub 2010 Jan 26. PMID: 20103647
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Autophagy Up-regulation, C-Jun N-Terminal Kinases (JNK) Modulator
[+]

Tanshinone IIA can inhibit the proliferation of K562 cells.Apr 30, 2014

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 May ;45(3):410-3. PMID: 24941807
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Tanshinone IIA induces autophagic cell death in KBM-5 leukemia cells.Feb 28, 2014

Pubmed Data : Phytother Res. 2014 Mar ;28(3):458-64. Epub 2013 Jun 27. PMID: 23813779
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

The results suggest that the six lactic acid bacteria mixture from kefir has strong effects on natural immunity and tumor cell cytotoxicity.Mar 26, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2018 Mar 27 ;7(4). Epub 2018 Mar 27. PMID: 29584690
Article Published Date : Mar 26, 2018
Study Type : In Vitro Study
Additional Links
Substances : Kefir
Diseases : Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Immunomodulatory
[+]

The study of extracellular protein fractions of probiotic candidate bacteria on cancerous cell line.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Iran Med. 2016 Nov ;19(11):779-785. PMID: 27845547
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus casei
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These results suggest bufalin can reverse drug resistance in K562/A02 cells.Apr 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Apr 7 ;25:2542-2552. Epub 2019 Apr 7. PMID: 30955024
Article Published Date : Apr 06, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bufalin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

This study provided a novel mechanism for the anti-leukemia effect of ursolic acid on K562 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:33358. Epub 2016 Sep 16. PMID: 27634378
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Trifolium repens blocks proliferation in chronic myelogenous leukemia.Feb 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 Feb 6 ;9(2). Epub 2020 Feb 6. PMID: 32041350
Article Published Date : Feb 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : White Clover
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative
[+]

Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.Jul 02, 2010

Pubmed Data : Curr Mol Pharmacol. 2010 Jul 2. Epub 2010 Jul 2. PMID: 20594187
Article Published Date : Jul 02, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Leukemia, Leukemia: Acute myelogenous leukemia (AML) , Leukemia: Chronic Lymphocytic Leukemia (CLL), Leukemia: Chronic myelogenous leukemia (CML) , Multiple Myeloma, Myelodysplastic Syndrome
Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor
[+]

Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Sep ;8(17):1046. PMID: 33145265
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Xanthohumol induces caspase-dependent degradation of oncoprotein BCR-ABL in K562 cells.Sep 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Sep 16 ;8(9). Epub 2019 Sep 16. PMID: 31527518
Article Published Date : Sep 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Oncoprotein BCR-ABL
[+]

Zerumbone induces mitochondria-mediated apoptosis in K562 chronic myelogenous leukemia cells.Oct 31, 2015

Pubmed Data : Tumour Biol. 2015 Nov ;36(11):8479-89. Epub 2015 May 31. PMID: 26026585
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic

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