Leukemias

Name	AC	CK
Curcumin	24	38
Beans: All	1	20
Green Tea	3	20
Nigella sativa (aka Black Seed)	2	20
Soy	1	20
Vegetables: All	1	20
Vitamin D	8	20
Vitamin K	1	20
Vitamin C	9	18
Resveratrol	10	17
Polyphenols	4	13
Aloe Vera	3	12
Berberine	9	11
Olive leaf extract	2	11
Vitamin K2	2	11
Chamomile	1	10
NAC (N-acetyl-L-cysteine)	1	10
Oleocanthal	1	10
Shikonin	6	10
Thymoquinone	9	10
Tualang Honey	1	10
Vitamin E	1	10
Deguelin	5	9
Ginsenosides	6	9
Vitamin C: Intravenous	3	9
Parthenolide	7	8
Fermented Foods and Beverages	3	7
Quercetin	6	7
Brown Rice	2	6
Rosemary	2	6
Carbon 60	4	5
EGCG (Epigallocatechin gallate)	4	5
Flavonoids	5	5
Graviola	1	5
Indole-3-Carbinol	4	5
Naringenin	3	5
Oridonin	5	5
Tanshinone IIA	4	5
Xanthohumol	4	5
Delta-tetrahydrocannabinol (THC)	3	4
EPA (Eicosapentaenoic Acid)	1	4
Honokiol	3	4
Piceatannol	4	4
Pterostilbene	4	4
Willow Bark	1	4
Wogonin	2	4
6-Shogaol	2	3
Agaricus Blazei	2	3
Betulinic acid	3	3
Blueberry	2	3
Cannabidiol	3	3
Cannabinoids	3	3
Carnosic Acid	3	3
DHA (Docosahexaenoic Acid)	3	3
Elecampane	3	3
Gallic Acid	3	3
Ginger	2	3
Gold (nanoparticles)	3	3
Isoliquiritigenin	2	3
Melatonin	2	3
Mistletoe	2	3
Poria cocos	1	3
Rose	2	3
Tomato	2	3
Wheat Germ	2	3
Anandamide	1	2
Anthocyanins	2	2
Apigenin	2	2
Ashwagandha	1	2
Avocado	2	2
Azelaic Acid	1	2
Bee Propolis	2	2
Bee Venom	2	2
Black hellebore	1	2
Cannabinoids: Synthetic	1	2
Capsaicin	2	2
Cat's Claw	1	2
Chinese Skullcap	2	2
Chokeberry	2	2
Cholesterol	1	2
Chrysin	1	2
Cordyceps Militaris	2	2
Cucurbitacin B	2	2
Emodin	2	2
Fenugreek	2	2
Feverfew	2	2
Fisetin	2	2
Fucoidan	2	2
Garlic	2	2
Genistein	1	2
Ginkgo biloba	1	2
Grape Seed Extract	2	2
Kefir	2	2
Lemon	1	2
Mangiferin	1	2
Neem	1	2
Nettle	2	2
Nobiletin	2	2
Piperine	2	2
Piperlongumine	1	2
Prunella vulgaris	1	2
Salvia miltiorrhiza	2	2
Sea buckthorn	2	2
Selenium	1	2
Sulforaphane	2	2
Allicin	1	1
Andrographis	1	1
Andrographolide	1	1
Arctigenin	1	1
Artesunate	1	1
Astaxanthin	1	1
Bael	1	1
Baicalein	1	1
Bamboo	1	1
Benzyl isothiocyanate	1	1
Beta-Caryophyllene	1	1
Beta-Elemene	1	1
Bilberry	1	1
Bitter Melon	1	1
Boswellia	1	1
Buckwheat	1	1
Burdock	1	1
Caffeic acid phenethyl ester	1	1
Carnosol	1	1
Carrot	1	1
Carvacrol	1	1
Chaga Mushroom (Inonotus obliquus)	1	1
Cissus quadrangularis	1	1
Cranberry Proanthocyanidins	1	1
Crocin	1	1
Crocodile Egg	1	1
Cruciferous Vegetables	1	1
Cucurbitacin D	1	1
Curcumol	1	1
Cysteine (see N-Acetylcysteine)	1	1
Diosgenin	1	1
Echinacea	1	1
Ellagic Acid	1	1
Feijoa	1	1
Fennel	1	1
Flaxseed	1	1
GABA (gamma-Aminobutyric Acid)	1	1
Garcinia hanburyi	1	1
Garden Cress (Lepidium sativum)	1	1
Ginseng, unspecified species	1	1
Greater celandine	1	1
Guarana	1	1
Hesperidin	1	1
Hops	1	1
Hyperforin	1	1
Indigo Naturalis	1	1
Jujube	1	1
Kaempferol	1	1
Lactobacillus reuteri	1	1
Lactobacillus rhamnosus GG	1	1
Lactoferrin	1	1
Lotus	1	1
Luteolin	1	1
Marijuana	1	1
Marjoram	1	1
Matairesinol	1	1
Medicinal Mushrooms	1	1
Moringa oleifera	1	1
Mugwort	1	1
Mulberry	1	1
Mushrooms: All	1	1
Myricetin	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Oak	1	1
Olive	1	1
Omega-3 Fatty Acids	1	1
Oregano	1	1
Paeoniflorin	1	1
Panax Notoginseng	1	1
Patchouli	1	1
Peony	1	1
Phyllanthus urinaria	1	1
Pomegranate Peel	1	1
Proanthocyanidins	1	1
Probiotics	1	1
Procyanidin B2	1	1
Raspberry	1	1
Red Sage	1	1
Red Wine Extract	1	1
Reishi Mushroom	1	1
Rose Hips	1	1
Royal Jelly	1	1
Sage	1	1
Saikosaponin	1	1
Silibinin	1	1
Stilbenes	1	1
Sweet Potato: Purple	1	1
Syrian rue	1	1
Tetrahydrocurcumin	1	1
Thymol	1	1
Tripterygium wilfordii	1	1
Triptolide	1	1
Verbascoside	1	1
Walnut	1	1
Watermelon	1	1
Xanthones	1	1
Zataria multiflora	1	1
Zinc	1	1

Name	AC	CK
Pesticides	3	40
Benzene	3	31
Cow Milk	1	20
Meat	1	20
Poultry	1	20
Agricultural Chemicals	1	10
Crude Oil/Petroleum	1	10
Dexamethasone	1	10
Herbicides	1	10
Infant Formula	1	10
Prednisone	1	10
Radon	1	10
Bisphenol A	2	3
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Benzene Metabolites	1	1
Ecotropic murine leukemia viruses (E-MLV)	1	1
Hepatitis Viruses	1	1
Hydroquinone	1	1
Morphine	1	1
Virus: Xenotropic murine leukemia virus-related virus (XMRV)	1	1
Xenotropic murine leukemia virus (X-MLV)	1	1

Name	AC	CK	Focus
Acupressure	1	10
Fasting/Caloric Restriction	1	4

Name	AC	CK
Electromagnetic Field Harms	10	107
Electromagnetic Radiation	8	95
Microwave Radiation	1	20
Vitamin K injections	1	20
Electromagnetic Radiation: 2.4 GHz	1	5

[+]

Infant vitamin K injections are associated with an increased risk for acute lymphoblastic leukaemia. Jan 17, 1998

Click here to read the entire abstract

Pubmed Data : BMJ. 1998 Jan 17;316(7126):189-93. PMID: 9468683

Article Published Date : Jan 17, 1998

Study Type : Meta Analysis

Additional Links

Substances : Vitamin K

Diseases : Acute lymphoblastic leukemia (ALL), Cancers: Pediatric

Anti Therapeutic Actions : Vitamin K injections

[+]

The result in this meta-analysis indicated that magnetic field exposure level may be associated with childhood leukemia.Mar 01, 2014

Click here to read the entire abstract

Pubmed Data : Leuk Res. 2014 Mar ;38(3):269-74. Epub 2013 Dec 15. PMID: 24388073

Click here to read the entire abstract

Pubmed Data : Holist Nurs Pract. 2016 Sep-Oct;30(5):257-62. PMID: 27501207

Article Published Date : Aug 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acute Myeloid Leukemia, Chemotherapy-Induced Nausea

Therapeutic Actions : Acupressure

[+]

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Click here to read the entire abstract

Pubmed Data : Infect Disord Drug Targets. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25809628

[+]

Pubmed Data : Occup Environ Med. 1997 Mar;54(3):152-66. PMID: 9155776

Article Published Date : Mar 01, 1997

Study Type : Human Study

Additional Links

Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Monocytic

Problem Substances : Benzene, Crude Oil/Petroleum

[+]

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2016 Dec 15. Epub 2016 Dec 15. PMID: 28000876

Article Published Date : Dec 14, 2016

Study Type : Human In Vitro

Additional Links

Substances : Resveratrol

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator

[+]

Shikonin induces apoptosis in HL-60 cells without significant effect on primary cells from healthy volunteers.Jul 14, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2016 Jul 15 ;39(2):604-616. Epub 2016 Jul 15. PMID: 27415599

Article Published Date : Jul 14, 2016

Study Type : Human In Vitro

Additional Links

Substances : Shikonin

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic

Additional Keywords : Dose Response

[+]

These results indicate that all analyzed cell lines including are highly sensitive to the cytotoxic, pro-oxidant effects of high doses of sodium ascorbate.Oct 31, 2015

Click here to read the entire abstract

Pubmed Data : Ann Hematol. 2015 Nov ;94(11):1807-16. Epub 2015 Aug 12. PMID: 26264692

Article Published Date : Oct 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Vitamin C: Intravenous

Diseases : Acute Myeloid Leukemia, Cancers: Drug Resistant, Lymphoma, Promyelocytic leukemia

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2023 ;18(5):e0285966. Epub 2023 May 19. PMID: 37205671

Article Published Date : Dec 31, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Apoptotic

[+]

Oxidative lipid damage by naringenin selectively sensitizes chronic myeloid leukemia cell lines.Sep 02, 2024

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2024 Sep 3 ;733:150653. Epub 2024 Sep 3. PMID: 39278089

Article Published Date : Sep 02, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Chronic Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

[+]

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila). 2015 Aug 19. Epub 2015 Aug 19. PMID: 26290393

Article Published Date : Aug 18, 2015

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Acute Myeloid Leukemia, Acute Myeloid Leukemia: Stem Cell

Pharmacological Actions : Chemopreventive

Additional Keywords : Cancer Stem Cells

[+]

Extracts of Neem leaf were effective in inducing apoptosis in leukemia and colon cancer cells.Oct 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharm Pharm Sci. 2015 Nov ;18(4):729-46. PMID: 26626256

Article Published Date : Oct 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Neem

Diseases : Acute T cell Leukemias, Colon Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Plant Extracts, Selective Cytotoxicity

[+]

Fasting selectively blocks development of acute lymphoblastic leukemia.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Nat Med. 2017 Jan ;23(1):79-90. Epub 2016 Dec 12. PMID: 27941793

Click here to read the entire abstract

Pubmed Data : Int J Biochem Cell Biol. 2015 Aug ;65:1-11. Epub 2015 May 12. PMID: 25979368

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: Imatinib, Philadelphia Chromosome-positive

[+]

Isoliquiritigenin selectively inhibited the viability of FLT3-ITD mutant acute myeloid leukemia cells.Aug 27, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2019 Aug 28. Epub 2019 Aug 28. PMID: 31462456

[+]

Spica prunellae extract has certain in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Afr J Tradit Complement Altern Med. 2013 ;10(5):318-24. Epub 2013 Aug 12. PMID: 24311843

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Prunella vulgaris

Diseases : Acute T cell Leukemias

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152.Dec 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2006 Jun 15;118(12):3012-21. PMID: 16395705

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2012 Jun 15 ;83(12):1634-42. Epub 2012 Mar 17. PMID: 22445931

Article Published Date : Jun 14, 2012

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Acute lymphoblastic leukemia (ALL), Cancers: Drug Resistant

Pharmacological Actions : Chemotherapeutic, NF-kappaB Inhibitor

[+]

Hot water extracts of ganoderma tsugae were effective in inhibiting the antiproliferation of C6, Hep 3B, and HL-60 cells.Dec 31, 2014

Article Published Date : Mar 18, 2009

Study Type : In Vitro Study

Additional Links

Substances : Agaricus Blazei

Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia

[+]

Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.Dec 31, 2019

Anti-cancer effects of ginsenoside compound k on pediatric acute myeloid leukemia cells.Mar 11, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Antiproliferative activity of walnut proteins and walnut protein hydrolysates.Sep 24, 2017

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Pubmed Data : J Med Food. 2017 Sep 25. Epub 2017 Sep 25. PMID: 28945497

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : NeuroImmune Pharm Ther. 2023 Mar 25 ;2(1):49-62. Epub 2023 Feb 17. PMID: 37027342

Article Published Date : Mar 24, 2023

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Acute T cell Leukemias

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex.May 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biosci Biotechnol Biochem. 2017 Jun ;81(6):1106-1113. Epub 2017 Mar 20. PMID: 28317437

Article Publish Status : This is a free article. Click here to read the complete article.

Betulinic acid-doxorubicin-drug combination induced apoptotic death via ROS stimulation in a relapsed AML MOLM-13 cell model.Sep 13, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2021 Sep 14 ;10(9). Epub 2021 Sep 14. PMID: 34573088

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Pubmed Data : Pharmaceutics. 2019 Nov 8 ;11(11). Epub 2019 Nov 8. PMID: 31717305

Article Published Date : Nov 07, 2019

Study Type : In Vitro Study

Additional Links

Substances : Berberine, Carbon 60

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Apoptotic

[+]

Cancer glycolytic dependence as a new target of olive leaf extract.Jan 28, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013090

Article Published Date : Jan 28, 2020

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Breast Cancer, Cancers: All, Chronic Myeloid Leukemia, Colon Cancer, Melanoma

Pharmacological Actions : Antiproliferative , Chemotherapeutic

Additional Keywords : Cancer Glycolysis

[+]

Click here to read the entire abstract

Pubmed Data : Leuk Res. 2007 Apr;31(4):523-30. Epub 2006 Sep 26. PMID: 17007926

Article Published Date : Apr 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Chinese Skullcap

Diseases : Acute lymphoblastic leukemia (ALL), Lymphoma, Multiple Myeloma

Pharmacological Actions : Apoptotic

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2019 Apr ;33(4):1199-1207. Epub 2019 Mar 5. PMID: 30834607

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic

[+]

Curcumin can be used as MDR modulator as well as chemosensitizer in combination with cytarabine.Aug 16, 2015

Click here to read the entire abstract

Pubmed Data : Anticancer Agents Med Chem. 2015 Aug 17. Epub 2015 Aug 17. PMID: 26278546

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 Nov ;12(5):4117-4124. Epub 2016 Sep 30. PMID: 27895780

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2021 Apr ;35(4):2157-2170. Epub 2020 Dec 4. PMID: 33274566

Article Published Date : Mar 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Chronic Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines.Nov 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Foods. 2017 Aug 28 ;6(9). Epub 2017 Aug 28. PMID: 28846628

Article Published Date : Aug 27, 2017

Study Type : In Vitro Study

Additional Links

Substances : Fennel

Diseases : Acute lymphoblastic leukemia (ALL), Breast Cancer, Cervical Cancer, Colorectal Cancer

Pharmacological Actions : Cytotoxic

Additional Keywords : Essential Oils

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2021 Dec 24 ;14(1). Epub 2021 Dec 24. PMID: 35008240

Enhancing effect of β-elemene emulsion on chemotherapy with harringtonine, aclacinomycin, and Ara-c in treatment of refractory/relapsed acute myeloid leukemia.Oct 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : BMC Complement Altern Med. 2012 Oct 30 ;12:202. Epub 2012 Oct 30. PMID: 23110539

Article Published Date : Oct 29, 2012

Study Type : In Vitro Study

Additional Links

Substances : Fenugreek

Diseases : Acute T cell Leukemias

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis in Jurkat T-cell leukemia tumor cells.Nov 28, 2002

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Food. 2004 Spring;7(1):19-23. PMID: 15117548

Article Published Date : Mar 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Brown Rice, GABA (gamma-Aminobutyric Acid)

Diseases : Acute lymphoblastic leukemia (ALL)

[+]

Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : J Cancer Res Clin Oncol. 2019 Aug ;145(8):1987-1998. Epub 2019 Jun 18. PMID: 31214760

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ginger

Diseases : Acute lymphoblastic leukemia (ALL), Cancers: Drug Resistant

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species.May 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biomed Pharmacother. 2020 Jan 30 ;125:109885. Epub 2020 Jan 30. PMID: 32007917

Article Published Date : Jan 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Multidrug Resistance Gene Modulators

Additional Keywords : Proanthocyanidins

[+]

Greater celandine (Chelidonium majus) induces programmed cell death in human acute lymphoblastic leukemia cells. Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Ukr Biokhim Zh. 2006 Sep-Oct;78(5):81-7. PMID: 17290785

Article Published Date : Sep 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Greater celandine

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Apoptotic

[+]

Guarana seeds have antibacterial, antineoplastic, and immunomodulatory activity.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:1203274. Epub 2016 Dec 7. PMID: 28053639

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Guarana

Diseases : Acute T cell Leukemias, Breast Cancer, Liver Cancer, Non-Hodgkin Lymphoma, Promyelocytic leukemia

Pharmacological Actions : Anti-Bacterial Agents, Antineoplastic Agents, Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Harmine can be considered as a potential treatment for acute myeloid leukemia.Nov 30, 2017

Click here to read the entire abstract

Pubmed Data : Indian J Hematol Blood Transfus. 2017 Dec ;33(4):509-515. Epub 2017 Jan 17. PMID: 29075061

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer Res Ther. 2015 Apr-Jun;11(2):352-7. PMID: 26148599

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin, Silibinin

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic

Additional Keywords : Dose Response, Drug: Cytarabine, Natural Substance/Drug Synergy

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Recept Signal Transduct Res. 2017 Oct ;37(5):506-514. PMID: 28812970

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Indole-3-carbinol synergizes with and restores fludarabine sensitivity in chronic lymphocytic leukemia cells .Dec 31, 2015

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Pubmed Data : Clin Cancer Res. 2016 Jan 1 ;22(1):134-45. Epub 2015 Aug 31. PMID: 26324744

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Chronic Lymphocytic Leukemia

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Induction of apoptosis by fucoidan in human leukemia U937 cells through activation of p38 MAPK and modulation of Bcl-2 family.Jul 03, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Molecules. 2021 Jan 14 ;26(2). Epub 2021 Jan 14. PMID: 33466806

Article Published Date : Jan 13, 2021

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol, Thymol

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Nobiletin down-regulates c-KIT gene expression and exerts anti-leukemic effects on human acute myeloid leukemia cells.Dec 02, 2018

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2018 Dec 3. Epub 2018 Dec 3. PMID: 30507186

Article Published Date : Dec 02, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Chemopreventive, Chemotherapeutic

[+]

Nobiletin may serve as a beneficial anti-leukemic agent for differentiation therapy.Apr 02, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Nov ;45(6):903-7. PMID: 25571712

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Pubmed Data : Nutr Cancer. 2016 Nov 23:1-10. Epub 2016 Nov 23. PMID: 27880058

Article Published Date : Nov 22, 2016

Study Type : In Vitro Study

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Survivin Down-Regulation, Tumor Suppressor Protein p53 Upregulation

[+]

PaDef a plant peptide triggers apoptosis, and induces global epigenetic modifications on histone 3 in an acute lymphoid leukemia cell line.Dec 31, 2021

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Pubmed Data : Front Mol Biosci. 2022 ;9:801816. Epub 2022 Jan 24. PMID: 35141282

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Pubmed Data : Mol Cancer. 2017 Jan 30 ;16(1):13. Epub 2017 Jan 30. PMID: 28137265

Article Published Date : Jan 29, 2017

Study Type : Review

Additional Links

Substances : Parthenolide

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Cancer Stem Cells

[+]

Parthenolide induced apoptosis and reduced osteopontin gene expression in U937 cells.Mar 31, 2016

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Phytochemical modulation of apoptosis and autophagy could be used to overcome chemoresistance in leukemic stem cells.Dec 31, 2016

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Pubmed Data : Int Rev Neurobiol. 2017 ;135:249-278. Epub 2017 Apr 12. PMID: 28807161

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2018 Feb ;15(2):1423-1428. Epub 2017 Nov 29. PMID: 29434833

Article Published Date : Jan 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

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View the Evidence: 364 Abstracts with Leukemias Research

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Infant vitamin K injections are associated with an increased risk for acute lymphoblastic leukaemia. Jan 17, 1998

The result in this meta-analysis indicated that magnetic field exposure level may be associated with childhood leukemia.Mar 01, 2014

High-dose glucocorticoid therapy in acute lymphoblastic leukemia children may cause prolonged adrenal suppression and related clinical symptoms.Mar 01, 2008

A variety of dietary factors may contribute to increased risk for leukemia. Mar 01, 1993

Acupressure band was effective for reducing the chemotherapy-induced nausea and vomiting.Aug 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Childhood cancer and traffic-related air pollution in Switzerland.Jun 29, 2022

Effect of chamomile on chemotherapy-induced neutropenia in pediatric leukemia patients.Dec 31, 2019

Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia.Apr 26, 2021

Efficacy of Aloe-Vera use for prevention of chemotherapy-induced oral mucositis.Feb 28, 2021

Green tea drinking suppresses proliferation of HTLV-1-infected lymphocytes in vivo.Jul 01, 2004

Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients.Jan 01, 2000

Incidence rates for chronic lymphocytic leukemia in the US states are significantly correlated with the levels of residential radon.Dec 31, 2015

Infant formula is associated with increased risk for acute lymphocytic leukemia (ALL), Hodgkin's lymphoma (HL). Apr 01, 2008

l-Ascorbic acid may be of clinical benefit in Acute Myeloid Leukemia and Myelodysplastic Syndromes. Mar 05, 2009

Myeloid leukemia was associated with benzene, a nonspecific group of solvents, occupational pesticides, and working with or near powerlines.Nov 01, 2009

Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia.Dec 31, 2018

Occupational electromagnetic field exposure in electrical workers may increase the risk of leukemia.Jan 01, 1992

Short-term survivors of intensive chemotherapy for AML had clinically meaningful declines in physical function. Sep 13, 2016

The consumption of cured meat is correlated with higher rates of childhood acute leukemia, whereas the consumption of vegetables and bean-curd food lowers risk. Jan 13, 2009

The effect of dietary intervention with high-oleocanthal and oleacein olive oil in Patients with early-stage chronic lymphocytic leukemia.Dec 31, 2020

The present cohort study suggests a protective effect of green tea against hematologic neoplasms, especially acute myeloid leukemias.Aug 25, 2019

The risk of acute lymphoblastic leukemia was elevated in young children with paternal occupational pesticide exposure during the perinatal period.Jun 30, 2017

This case control study found that pre and post natal exposure to high voltage power lines could be described as risk factor of ALL for the first time.Dec 31, 2014

This large cohort study indicates an increased risk of acute myeloid leukemia and follicular lymphoma among men with extremely-low frequency electromagnetic field exposure.Feb 01, 2014

This pooled analysis found an increased risk of childhood leukemia associated with proximity to power lines.Jan 01, 2018

Utilization of photobiomodulation for the prevention and treatment of oral mucositis.Dec 31, 2023

Vitamin E and N-acetylcysteine are an effective antioxidant adjuvant therapy in children with acute lymphoblastic leukemia to reduce the chemo-/radiotherapy toxicity of treatment. Jan 01, 2009

Workers exposed to petroleum products may have increased risk for certain leukemias, in part due to benzene exposure.Mar 01, 1997

2.45 GHz electromagnetic radiation exposure stimulates proliferation in human leukemia cancer cells via oxidative stress and calcium influx.Jun 01, 2012

900 MHz electromagnetic fields may confer survival benefits to T-lymophoblastoid leukemia cells.Feb 01, 2004

Curcumin inhibited proliferation and induced apoptosis in both KG-1 and U937 cells.Jun 30, 2016

Extremely low frequency electromagnetic fields promote the differentiation of acute promyelocytic leukemia cells by all-trans retinoic acid.Jan 01, 2018

Fermented brown rice extract causes apoptotic death of human acute lymphoblastic leukemia cells.Jan 13, 2016

Graviola extracts inhibited the proliferation of HL-60 cells in a concentration dependent manner and induced apoptosis.Dec 31, 2013

Resveratrol markedly decreased the overexpression of miR-196b/miR-1290 and elevated IGFBP3 expression in the ALL cell lines.Dec 14, 2016

Shikonin induces apoptosis in HL-60 cells without significant effect on primary cells from healthy volunteers.Jul 14, 2016

These results indicate that all analyzed cell lines including are highly sensitive to the cytotoxic, pro-oxidant effects of high doses of sodium ascorbate.Oct 31, 2015

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Tualang honey produced a significant apoptosis effect on both acute and chronic leukemia cell lines.Dec 31, 2014

A case of complete and durable molecular remission of chronic lymphocytic leukemia following treatment with epigallocatechin-3-gallate.Dec 31, 2014

A case report of vitamin B12 deficiency mimicking acute leukemia.Sep 30, 2019

A rare case of spontaneous remission of terminal deoxynucleotidyl transferase negative B-acute lymphoblastic leukemia.Dec 31, 2017

Ginsenoside 24-OH-PD from red ginseng inhibits acute T-lymphocytic leukaemia.Dec 31, 2022

Oxidative lipid damage by naringenin selectively sensitizes chronic myeloid leukemia cell lines.Sep 02, 2024

Poricoic acid A (PAA) inhibits T-cell acute lymphoblastic leukemia through inducing autophagic cell death and ferroptosis.Jun 10, 2022

Spontaneous remission in a patient with acute myeloid leukemia leading to undetectable minimal residual disease.Mar 31, 2020

The cautionary tale warns against diagnosing acute myeloid leukemia before ruling out Vitamin B12 deficiency.Dec 31, 2020

This case study highlights the benefits of IV vitamin C as a supportive therapy for previously relapsed acute myeloid leukaemia.Jul 15, 2018

"Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia."Jun 30, 2012

6-Shogaol induces apoptosis in acute lymphoblastic leukaemia cells.May 02, 2021

Azelaic acid significantly inhibits the cell viability and induces apoptosis in AML cells in a dose-dependent manner.Dec 31, 2016

BPA can trigger the malignancy of acute myeloid leukemia cells. May 05, 2021

Cannabinoids were effective in reducing the tumor load, prolonging the mean survival time as well as curing a significant proportion of mice in this study.Jul 14, 2002

Cholesterol derived from LDL acts as a chemosensitizer in multidrug resistant lymphoblastic leukemia cells.Oct 01, 2007

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death.Aug 13, 2015

Curcumin inhibits proliferation and induces programmed cell death in leukemic cells and prolongs survival of mice with acute lymphoblastic leukemia. Sep 24, 2008

Curcumin inhibits the growth of HTLV-1 infected T-cell tumors implanted into mice, indicating its potential value in the treatment of Adult T-cell leukemia. Feb 01, 2006

EPA supplementation was effective in a murine model of acute myeloid leukemia. Aug 18, 2015

Extracts of Neem leaf were effective in inducing apoptosis in leukemia and colon cancer cells.Oct 31, 2015

Fasting selectively blocks development of acute lymphoblastic leukemia.Dec 31, 2016

Genistein increases the efficacy of fludarabine in inducing cell death in blood cells from CLL and PLL patients. Apr 01, 2007

Ginkgetin effectively inhibits K562 cell proliferation.Oct 25, 2017

Honokiol-chlorambucil co-prodrugs selectively enhance the killing effect through STAT3 binding on lymphocytic leukemia cells.Aug 10, 2020

In Ph+ ALL mouse models, curcumin exhibited synergetic anti-leukemia effects with imatinib.Jul 31, 2015

Isoliquiritigenin selectively inhibited the viability of FLT3-ITD mutant acute myeloid leukemia cells.Aug 27, 2019

Mangiferin induces immune responses and evaluates the survival rate in WEHI-3 cell generated mouse leukemia in vivo.Sep 04, 2020

OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia.Nov 14, 2013

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemiaFeb 20, 2013

Results from the present study indicated that α tomatine may have useful anti leukemia activities.May 31, 2015

Rosemary may have therapeutic value in the treatment of acute myeloid leukemia. Jan 01, 2008

Selenium can trigger apoptosis in cancer stem like cells by modulation of arachidonic acid metabolism.Jul 14, 2014

Leukemias

View the Evidence:
364 Abstracts with Leukemias Research