Liver Damage

Name	AC	CK
Curcumin	64	132
NAC (N-acetyl-L-cysteine)	16	55
Polyphenols	18	34
Vitamin C	14	34
Flavonoids	19	33
Saffron	7	32
Silymarin	12	32
Ginsenosides	17	30
Milk Thistle	4	26
Nigella sativa (aka Black Seed)	14	26
Thymoquinone	14	26
Puerarin	12	22
Resveratrol	10	22
Dandelion	10	20
Vitamin D	6	20
Ginger	9	18
Melatonin	6	18
Moringa oleifera	8	18
Anthocyanins	8	16
Grape Seed Extract	8	16
Hydrogen Water	4	16
Lycopene	8	16
Turmeric	8	16
Zinc	4	16
Silibinin	4	15
Alpha-Lipoic Acid	7	14
Beet	7	14
Fermented Foods and Beverages	7	14
Fucoidan	8	14
Ginkgo biloba	7	14
Naringenin	8	14
Selenium	6	14
Vitamin E	7	14
Artichoke	7	13
Astaxanthin	8	13
Pomegranate	7	13
Black Tea	6	12
Crocin	6	12
Garlic	6	12
Honey	6	12
Lactobacillus plantarum	6	12
Sulforaphane	8	12
Turmeric: Fermented	2	12
EGCG (Epigallocatechin gallate)	6	11
Olive leaf extract	6	11
Phyllanthus urinaria	2	11
Rose	6	11
Rosemary	6	11
Apigenin	6	10
Blueberry	5	10
Chlorella (Algae)	4	10
Diosmin	5	10
Geraniol	5	10
Green Tea	5	10
Honeysuckle	5	10
Lignans	6	10
Mangiferin	5	10
Mulberry	6	10
Quercetin	5	10
Radish	6	10
Reishi Mushroom	5	10
Royal Jelly	4	10
Schisandra	6	10
Sesamol	3	10
Asiatic Acid	5	9
Berberine	5	9
Caffeic acid phenethyl ester	5	9
Citrus naringin	5	9
Licorice	6	9
Bael	4	8
Bee Propolis	4	8
Camel Milk	4	8
Carvacrol	4	8
Chokeberry	4	8
Chrysin	4	8
Coenzyme Q10	4	8
Dates	4	8
Diallyl sulfide	4	8
Ellagic Acid	4	8
Fenugreek	4	8
Garlic: Aged	4	8
Genistein	4	8
Hesperidin	4	8
Jujube	4	8
Olive Oil	4	8
Paeonol	4	8
Sea buckthorn	4	8
Sweet Potato: Purple	4	8
White Tea	4	8
Apple	4	7
Citrus Peel	4	7
Gingerol	4	7
Medicinal Mushrooms	4	7
Oridonin	4	7
Zataria multiflora	4	7
Acacia catechu	3	6
Bamboo	3	6
Blue Honeysuckle	3	6
Carrot	3	6
Catechin	3	6
Celery	3	6
Chlorogenic Acid	3	6
Date Seeds	2	6
Garden Cress (Lepidium sativum)	3	6
Glycyrrhizin	3	6
Gotu Kola	3	6
Grape	3	6
Hydroxytyrosol	3	6
Isoliquiritigenin	3	6
Lactobacillus casei	3	6
Liquiritigenin	3	6
Luteolin	3	6
Oregano	4	6
Pterostilbene	3	6
Safflower	3	6
Shikonin	3	6
Solanum nigrum (black nightshade)	3	6
Spirulina	3	6
Yellow Tea	3	6
Amygdalin (laetrile)	3	5
Emodin	3	5
Fig	3	5
Genipin	3	5
Indole-3-Carbinol	3	5
Lotus	4	5
Paeoniflorin	3	5
Poria cocos	3	5
Rooibos	3	5
Ursolic Acid	3	5
Apple Polyphenols	2	4
Apricot	2	4
Artesunate	1	4
Ayurvedic formulation: Liv52	2	4
Bee Venom	2	4
Beeswax	2	4
Berries: All	2	4
Betanin	2	4
Biochanin A	2	4
Bitter Melon	2	4
Black Raspberry	2	4
Burdock	2	4
Chamomile	2	4
Chicory	2	4
Choline	2	4
Coffee: Green/Unroasted	2	4
Cordyceps sinensis	2	4
Cranberry	2	4
Crocetin	2	4
Cucurbitacin B	2	4
DHA (Docosahexaenoic Acid)	2	4
Dill	2	4
EPA (Eicosapentaenoic Acid)	2	4
Embelia ribes	2	4
Eriodictyol	2	4
Fisetin	2	4
Flaxseed	2	4
Frankincense	2	4
Ginseng	2	4
Guduchi	2	4
Henna	2	4
Hibiscus sabdariffa	2	4
Hu Zhang (Polygonum cuspidatum)	1	4
Juniper	2	4
Kefir	2	4
Kombucha Tea	3	4
Lactobacillus probiotics	2	4
Ligustrazine	2	4
Litchi	2	4
Lychee	2	4
Mangosteen	2	4
Myricetin	2	4
Nobiletin	2	4
Noni	2	4
Onion	2	4
Orthosiphon	2	4
Oyster Mushroom	2	4
Panax Notoginseng	2	4
Papaya	2	4
Passion Flower	2	4
Phellinus Linteus	2	4
Phloretin	3	4
Piceatannol	2	4
Piperine	2	4
Pomegranate Peel	2	4
Pomegranate Seed	2	4
Potato	2	4
Probiotics	2	4
Propolis: Bee	2	4
Prunella vulgaris	2	4
Raspberry	2	4
Raspberry ketone	2	4
Shiitake Mushroom	2	4
Stevia	2	4
Verbascoside	2	4
Vitexins	2	4
Walnut	2	4
Xanthohumol	2	4
Yeast	2	4
Zerumbone	2	4
Allicin	2	3
Astragalus	2	3
Barley	2	3
Chaga Mushroom (Inonotus obliquus)	2	3
D-Limonene	2	3
Gallic Acid	2	3
Guava	2	3
Indian Mulberry	2	3
Lactobacillus fermentum	2	3
Mugwort	2	3
Nutmeg	2	3
Oleanolic acid	2	3
Peony	2	3
Phlorotannins	2	3
Prickly Pear Cactus	2	3
Punicalagin	2	3
Terminalia chebula	2	3
Theanine	2	3
Thistle	2	3
Watercress	2	3
Ajwain	1	2
Almond	1	2
Aloe Vera	1	2
Alpha Linolenic Acid	1	2
Amygdalin	1	2
Andrographis	1	2
Angelica	1	2
Anise	1	2
Antrodia camphorata	1	2
Apocynin	1	2
Apple Cider Vinegar	1	2
Apples	1	2
Apricot Kernel	1	2
Arginine	1	2
Ashwagandha	1	2
Astragaloside	2	2
Baccharis trimera	1	2
Bacopa	1	2
Baicalein	1	2
Banana Peel	1	2
Banana Stem	1	2
Barberry	1	2
Basil	1	2
Bee Pollen	1	2
Benzyl isothiocyanate	1	2
Berbamine	1	2
Beta Sitosterol	1	2
Beta-Caryophyllene	1	2
Betaine	1	2
Bilberry	1	2
Bile salts	1	2
Bitter Apple	1	2
Bitter Orange	1	2
Black Currant	1	2
Black Tea Theaflavins	1	2
Broccoli Sprouts	1	2
Bromelain	1	2
Buckwheat	1	2
Butterbur	1	2
Cabbage	1	2
Caffeine	1	2
Cannabidiol	1	2
Capsaicin	1	2
Carnosic Acid	1	2
Carotenoids	1	2
Celastrol	1	2
Celosia cristata (cockscomb)	1	2
Centella asiatica	1	2
Chickpea	1	2
Chrysanthemum Indicum	1	2
Cinnamon	1	2
Cissus quadrangularis	1	2
Citric Acid	1	2
Coconut Oil	1	2
Coconut Water	1	2
Cordyceps Militaris	1	2
Coriandrum sativum	1	2
Cumin	1	2
Curcumol	1	2
Cysteine (see N-Acetylcysteine)	1	2
Dibenzoylmethane (DBM)	1	2
Diosmetin	1	2
Earthworms	1	2
Echinacea	1	2
Eggplant	1	2
Elderberry	1	2
Eugenol	1	2
False Black Pepper	1	2
Fennel	1	2
Ferulic acid	1	2
Feverfew	1	2
Fish Oil	1	2
Folic Acid	1	2
Formononetin	1	2
Geranium	1	2
Ginseng (Korean)	1	2
Ginseng (Siberian)	1	2
Glycyrrhiza uralensis	1	2
Goat Milk	1	2
Goji	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Graviola	1	2
Harmine	1	2
Hibiscus rosa-sinensis	1	2
Holy Basil	1	2
Hops	1	2
Horehound	1	2
Horse Chestnut	1	2
Indian Gooseberry	1	2
Isoflavones	1	2
Isothiocyanates	1	2
Kimchi	1	2
Lactobacillus paracasei	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus GG	1	2
Lactobacillus salivarius	1	2
Lactoferrin	1	2
Lavender	2	2
Lemon	1	2
Lobelia	1	2
Long Pepper	1	2
Loquat	1	2
Loquat Seeds	1	2
Lutein	1	2
Magnesium	1	2
Mango	1	2
Mango leaf	1	2
Maple Syrup	1	2
Mint	1	2
Miso	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Myrica rubra	1	2
Nettle	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Oak	1	2
Okra	1	2
Oleuropein	1	2
Olive	1	2
Orange	1	2
Orange: Mandarin	1	2
Palash	1	2
Palmitoylethanolamide	1	2
Pecan	1	2
Peppermint	1	2
Phosphatidylcholine	1	2
Pine Bark Extract	1	2
Piper cubeba (Cubeb)	1	2
Plant Stem Cells	1	2
Plantago asiatica	1	2
Proanthocyanidins	1	2
Propolis: Brazillian	1	2
Pterocarpus marsupium	1	2
Pumpkin	1	2
Pumpkin Seed Oil/Meal	1	2
Purslane	1	2
Raisins	1	2
Red Cabbage	1	2
Red Sage	1	2
Red Wine	1	2
Rhubarb	1	2
Rice Bran	1	2
Rice: Brown	1	2
Rice: Parboiled	1	2
Rosemaric Acid	1	2
Rosmarinic acid	1	2
Safranal	1	2
Sage	1	2
Saikosaponin	1	2
Salvia miltiorrhiza	1	2
Seaweed	1	2
Semecarpus anacardium	1	2
Sesame Seed Oil	1	2
Sesamin	1	2
Sessile Joyweed	1	2
Silica Hydride	1	2
Soy	1	2
Stilbenes	1	2
Strawberry	1	2
Tannic Acid	1	2
Tanshinone IIA	2	2
Taro	1	2
Taurine	1	2
Thyme	1	2
Thymol	1	2
Toona sinensis	1	2
Tyrosine	1	2
Urine	1	2
Urine: Cow	1	2
Vanillin	1	2
Water: Deuterium Depleted	1	2
Water: Electrolyzed Reduced	1	2
Whey	1	2
Xanthones	1	2
Yoghurt	1	2
beta-Carotene	1	2
Agrimony	1	1
Babchi	1	1
Blackberry	1	1
Caraway	1	1
Clove	1	1
Coffee	1	1
Coriandor	1	1
Curcuminoids	1	1
Cyanidin 3-glucoside	1	1
Cyperus longus	1	1
Dong Quai	1	1
Fucoxanthin	1	1
Gynostemma	1	1
Haritaki (Terminalia chebula)	1	1
Honokiol	1	1
Hydrangea	1	1
Kudzu	1	1
Lupeol	1	1
Motherwort	1	1
Mung Bean	1	1
Oat Bran	1	1
Procyanidin B2	1	1
Rice: Black	1	1
Sweet Potato	1	1
Tangeretin	1	1
Tarragon	1	1
Tetrahydrocurcumin	1	1
Vitex negundo	1	1
Water Mint	1	1
Wheat Grass	1	1
White Mulberry	1	1

Name	AC	CK
Acetaminophen	98	199
Paracetamol	91	174
Statin Drugs	22	124
Simvastatin	9	77
Atorvastatin	12	69
Isoniazid	4	62
Bisphenol A	22	54
Pravastatin	5	45
Aflatoxin	13	41
Fluvastatin	3	40
Lovastatin	7	36
Cadmium	19	33
Concanavalin A	16	32
Pesticides	12	23
Lead	10	20
High Fructose Corn Syrup	6	19
Rosuvastatin	4	17
Glyphosate	9	16
Arsenic	8	14
Tamoxifen	4	14
Tylenol	2	14
Mercury	5	13
Diclofenac	5	12
Fluoroquinolone Antibiotic	2	12
Perfluorooctanoic acid (PFOA)	2	12
Proton-Pump Inhibitors	1	10
Fluoxetine (trade name Prozac)	4	9
Aspartame	4	8
Dichloro-diphenyl-trichloroethane (DDT)	4	8
Monosodium Glutamate (MSG)	4	8
Morphine	4	8
Tertiary butyl hydroperoxide	7	8
Bisphenol S	4	7
Electronic Cigarettes	4	7
Organophosphate Pesticides	4	7
2-chlorobenzylidene malononitrile (CS)	1	6
Chlorpyrifos	3	6
Quizalofop-P-ethyl	1	6
Sodium Fluoride	3	6
Acrylamide	3	5
Paraquat	3	5
Zinc Oxide	3	5
Aluminum	2	4
Arsenic Trioxide	2	4
Arsenite	2	4
Benzo(a)pyrene	2	4
Butylated Hydroxytoluene (BHT)	2	4
Cisplatin	2	4
Deltamethrin	2	4
Dichlorvos	2	4
Formaldehyde	2	4
Fructose	2	4
Furan	2	4
N-nitrosodiethylamine	2	4
Nanoparticles	2	4
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	4
Perfluorooctane sulfonate (PFOS)	2	4
Rosiglitazone (trade name Avandia)	2	4
Sucralose (aka Splenda)	2	4
Sugar Sweetened Beverages	2	4
Titanium Dioxide	2	4
Titanium Nanoparticles	2	4
Amiodarone	2	3
Cerivastatin	1	3
Cholesterol Lowering Drugs	1	3
Fenofibrates	1	3
Fluconazole	1	3
Methotrexate	2	3
Triclosan	2	3
Aluminum Hydroxide	1	2
Antibiotics	1	2
Benzene	1	2
Bisphenol F	1	2
Brilliant Blue FCF	1	2
Cobalt	1	2
Copper Oxide	1	2
Cypermethrin	1	2
Dexamethasone	1	2
Dichlorodiphenyldichloroethylene (DDE)	1	2
Erythrosine	1	2
Ethylene Glycol	1	2
FD&C Red #40	1	2
Fluoride	1	2
Food Colorings	1	2
Formaldehyde Releasers	1	2
Glyphosate:Roundup	1	2
Insulin	1	2
Levofloxacin	1	2
Metanil-Yellow Dye	1	2
N-nitrosodimethylamine	1	2
Organochlorine pesticides	1	2
Organophosphates	1	2
Paclitaxel	1	2
Phthalates	1	2
Ponceau 4R (New Coccine)	1	2
Pyrethroid insecticide	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Silver	1	2
Sucrose	1	2
Tartrazine (Yellow Food Dye)	1	2
Thiazolidinediones	1	2
Toluene	1	2
Trans Fatty Acids	1	2
Vaccine Adjuvants	1	2
Zoledronic Acid	1	2
Dimethoate	1	1
Irinotecan	1	1
Parabens	1	1
Polychlorinated biphenyls (PCBs)	1	1
Zineb	1	1

Name	AC	CK
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Sunlight exposure	1	10
Stem Cell Related Therapy	2	3
Exercise	1	2
Exercise: Aerobic	1	2
Exercise: Swimming	1	2
Hyperbaric Treatment	1	2
Traditional Chinese Medicine	1	1

Name	AC	CK
Western Diet	4	8
Mobile Phone Radiation	2	4
Electromagnetic Field Harms	1	2
Electromagnetic Radiation	1	2
Vaccination: All	1	2
Vaccination: Hepatitis B	1	2
Nanotechnology	1	1

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents

Additional Keywords : Anti-Obesity Agents

[+]

Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease.Jun 04, 2017

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Pubmed Data : J Pharm Biomed Anal. 2017 Jun 5 ;140:105-112. Epub 2017 Mar 10. PMID: 28346880

Article Published Date : Jun 04, 2017

Study Type : Human In Vitro, Human Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage

Additional Keywords : Bisphenol A, Bisphenol Toxicity, Chemically-Induced Liver Damage

Problem Substances : Bisphenol A

[+]

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

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Pubmed Data : Klin Med (Mosk). 2013 ;91(3):50-3. PMID: 23789453

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2013 ;13:58. Epub 2013 Mar 8. PMID: 23497020

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Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469

Phyllanthus Urinaria is useful in preventing or delaying the development of HBV-associated cirrhosis to hepatocellular carcinoma.Mar 24, 2013

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Pubmed Data : Chin J Integr Med. 2013 Mar 25. Epub 2013 Mar 25. PMID: 23529834

Article Published Date : Mar 24, 2013

Study Type : Human Study

Additional Links

Substances : Phyllanthus urinaria

Diseases : Liver Cancer: Hepatitis B Associated, Liver Cancer: Prevention, Liver Cirrhosis, Liver Damage

Pharmacological Actions : Chemopreventive

Additional Keywords : Significant Treatment Outcome

[+]

Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients.Feb 29, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pak J Med Sci. 2020 Mar-Apr;36(3):445-450. PMID: 32292450

Article Published Date : Feb 29, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Hepatitis C, Liver Damage, Vitamin D Deficiency

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Hepatoprotective

Additional Keywords : Increased Risk

[+]

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):334. Epub 2015 Sep 23. PMID: 26400476

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Liver Damage: Drug-Induced, Tuberculosis

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

[+]

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

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Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933

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Pubmed Data : Nutr Cancer. 1999 ;35(1):27-33. PMID: 10624703

Article Published Date : Jan 01, 1999

Study Type : Human Study

Additional Links

Diseases : Aflatoxicosis, Liver Cancer, Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation

Problem Substances : Aflatoxin

Adverse Pharmacological Actions : Carcinogenic

[+]

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Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Article Published Date : Jan 31, 2017

Study Type : Human In Vitro

Additional Links

Substances : Mangiferin

Diseases : Chemically-Induced Liver Damage, Mercury Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Additional Keywords : Methylmercury

Problem Substances : Mercury

[+]

Procyanidin B2 alleviates palmitic acid-Induced injury in HepG2 cells.Dec 31, 2020

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Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

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Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141

Article Published Date : May 18, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Cerivastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

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Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016

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Pubmed Data : Drug Chem Toxicol. 2021 Aug 18:1-7. Epub 2021 Aug 18. PMID: 34407699

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Pubmed Data : Environ Health Prev Med. 2017 Jun 12 ;22(1):54. Epub 2017 Jun 12. PMID: 29165178

Article Published Date : Jun 11, 2017

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

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Pubmed Data : Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. PMID: 17112692

Article Published Date : Feb 07, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Phosphatidylcholine

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

A maple syrup extract alleviates liver injury in type 2 diabetic model mice.Oct 23, 2019

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Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Pubmed Data : Environ Toxicol. 2020 Feb 25. Epub 2020 Feb 25. PMID: 32096903

Article Published Date : Feb 24, 2020

Study Type : Animal Study

Additional Links

Substances : Eugenol

Diseases : Chemically-Induced Liver Damage, Pesticide Toxicity

Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Chlorpyrifos

[+]

Aged black garlic has hepatoprotective effects and suggests that supplementation might be a good adjuvant therapy for the management of liver injury.Feb 28, 2014

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Pubmed Data : Environ Toxicol Pharmacol. 2018 Feb 23 ;59:17-23. Epub 2018 Feb 23. PMID: 29500983

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Pubmed Data : Biol Trace Elem Res. 2021 Apr 17. Epub 2021 Apr 17. PMID: 33866498

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Pubmed Data : Molecules. 2020 Jun 5 ;25(11). Epub 2020 Jun 5. PMID: 32517066

Article Published Date : Jun 04, 2020

Study Type : Animal Study

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Substances : Bee Pollen, Bee Propolis, Honey, Royal Jelly

Diseases : Chemically-Induced Liver Damage, Kidney Damage, Pesticide Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Pesticides

[+]

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity.Feb 19, 2019

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Pubmed Data : Drug Chem Toxicol. 2019 Feb 20:1-7. Epub 2019 Feb 20. PMID: 30782023

[+]

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

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Pubmed Data : Iran J Basic Med Sci. 2015 Feb ;18(2):205-11. PMID: 25825639

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 11:e22472. Epub 2020 Feb 11. PMID: 32048452

Article Published Date : Feb 10, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

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Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa root extract prevents lead-induced liver injury.Nov 23, 2019

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Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282

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Pubmed Data : Springerplus. 2016 ;5:216. Epub 2016 Feb 29. PMID: 27026910

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hepatoprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

[+]

Artificial sweeteners cause cytoplasmic fatty change of varying degrees.Aug 31, 2019

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Pubmed Data : J Coll Physicians Surg Pak. 2019 Sep ;29(9):848-851. PMID: 31455480

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Fatty Liver

Problem Substances : Aspartame, Sucralose (aka Splenda)

[+]

Ascorbic acid ameliorates cardiac and hepatic toxicity induced by azithromycin-etoricoxib drug interaction.May 30, 2022

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Pubmed Data : Curr Issues Mol Biol. 2022 May 31 ;44(6):2529-2541. Epub 2022 May 31. PMID: 35735613

Article Published Date : May 30, 2022

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Antibiotic Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Cardioprotective, Hepatoprotective

Additional Keywords : Synergistic Toxicity

Problem Substances : Antibiotics, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Assessment of hepatoprotective effect of chokeberry juice in tats treated chronically with carbon tetrachloride.Mar 10, 2020

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Pubmed Data : Molecules. 2020 Mar 11 ;25(6). Epub 2020 Mar 11. PMID: 32168847

Article Published Date : Mar 10, 2020

Study Type : Animal Study

Additional Links

Substances : Chokeberry

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Association between serum CK-18 levels and the degree of liver damage in fructose-induced metabolic syndrome.Aug 31, 2018

Pubmed Data : Mar Drugs. 2021 Sep 18 ;19(9). Epub 2021 Sep 18. PMID: 34564187

Article Published Date : Sep 17, 2021

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.May 31, 2021

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

Article Published Date : Aug 19, 2018

Study Type : Animal Study

Additional Links

Substances : Bael , Piperine

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

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Pubmed Data : Mediators Inflamm. 2014 ;2014:196598. Epub 2014 Nov 12. PMID: 25435714

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Baccharis trimera

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

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Pubmed Data : Heliyon. 2016 Feb ;2(2):e00068. Epub 2016 Feb 15. PMID: 27441247

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Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313

Article Published Date : Jul 20, 2016

Study Type : Animal Study

Additional Links

Substances : Barley

Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Bees' honey attenuation of metanil-yellow-induced hepatotoxicity in rats.Dec 31, 2012

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Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:614580. Epub 2013 Jun 3. PMID: 23818929

Article Published Date : Dec 31, 2012

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Pubmed Data : Food Chem Toxicol. 2012 Jun ;50(6):2027-33. Epub 2012 Mar 24. PMID: 22465004

Article Published Date : May 31, 2012

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage, DNA damage

Pharmacological Actions : Hepatoprotective

Problem Substances : N-nitrosodiethylamine

Adverse Pharmacological Actions : Hepatotoxic

[+]

Beetroot protects the liver against chemical toxicity.Feb 01, 2006

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Pubmed Data : Fitoterapia. 2006 Feb;77(2):91-3. Epub 2005 Dec 20. PMID: 16376022

Article Published Date : Feb 01, 2006

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Beetroot water extract could be used following silver nano particles as a potential therapeutic intervention to minimize liver toxicity.Dec 31, 2019

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Pubmed Data : Int J Nanomedicine. 2020 ;15:3471-3482. Epub 2020 May 15. PMID: 32547008

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Silver

[+]

Benzyl isothiocyanate produced by garden cress prevents accumulation of hepatic lipids.Dec 31, 2019

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

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Pubmed Data : Am J Med Sci. 2022 Apr 12. Epub 2022 Apr 12. PMID: 35427583

Article Published Date : Apr 11, 2022

Study Type : Animal Study

Additional Links

Substances : Barberry

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective

[+]

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure.Jan 10, 2020

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Pubmed Data : Food Res Int. 2020 11 ;137:109461. Epub 2020 Jun 18. PMID: 33233135

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Pubmed Data : J Biochem Mol Toxicol. 2021 Nov ;35(11):e22901. Epub 2021 Sep 2. PMID: 34472159

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Substances : Betulinic acid

Diseases : Chemically-Induced Liver Damage, Inflammation, Kidney Damage: Chemically-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : N-nitrosodimethylamine

[+]

Betulinic acid can be used as an effective agent in the prevention and treatment of acute liver diseases.Mar 27, 2021

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Pubmed Data : Turk J Med Sci. 2021 Mar 28. Epub 2021 Mar 28. PMID: 33773522

The Following are Sub-Topics of Liver Damage

View the Evidence: 1399 Abstracts with Liver Damage Research

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Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.Oct 11, 2021

Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.Jul 31, 2020

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

Saffron supplementation can reduce ALT serum concentrations without significant effects on other liver function indicators.Mar 15, 2021

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Acetylcysteine for the treatment of suspected remdesivir-associated acute liver Failure in COVID-19.Oct 01, 2020

Almond protects the liver in coronary artery disease.Feb 28, 2021

Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis.May 01, 2021

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Beneficial effects of ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese.Feb 28, 2021

Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease.Jun 04, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Exposure of children to even low doses of BPA may adversely affect later liver function.Nov 16, 2017

Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.Dec 31, 2012

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.Aug 12, 2012

Fluvastatin has been linked to adverse hepatic reactions.Jan 01, 2006

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.Dec 15, 2009

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms. Jul 01, 2005

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

N-acetylcysteine supplementation for the prevention of postoperative liver dysfunction after on-pump cardiac surgery.Nov 30, 2021

NAC has a therapeutic effect on hepatotoxicity in children being treated with chemotherapeutic agents.Mar 31, 2020

NAC should be considered in management of anti-tuberculosis drug induced liver injury.Aug 25, 2020

Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients.Apr 15, 2021

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Phyllanthus Urinaria is useful in preventing or delaying the development of HBV-associated cirrhosis to hepatocellular carcinoma.Mar 24, 2013

Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients.Feb 29, 2020

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.Mar 05, 2010

Silibinin could be beneficial in preventing drug-induced liver injury in tuberculosis treatments. Dec 31, 2014

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

The association between N-acetylcysteine treatment and hepatic healing in patients with non-acetaminophen-induced liver injury.Jan 31, 2022

The effect of acetyl-L-carnitine, alpha-lipoic acid, and coenzyme Q10 combination in preventing anti-tuberculosis drug-induced hepatotoxicity.Dec 31, 2020

There is evidence that aflatoxin exposure plays a role in the pathogenesis of liver cancer in the US population. Jan 01, 1999

Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess.Feb 28, 2018

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of Aflatoxin B1 in wheat miller workers.Jun 12, 2019

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.Aug 23, 2015

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

Procyanidin B2 alleviates palmitic acid-Induced injury in HepG2 cells.Dec 31, 2020

Protective effects of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles on H2O2-induced oxidative stress in HepG2 cells.May 28, 2022

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

A case report of fluoxetine-induced Stevens-Johnson syndrome and liver injury.Jan 31, 2019

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Acute exposure to CS tear gas has been reported to cause several health problems in an individual.Dec 26, 1981

Acute hepatitis induced by lovastatin has been reported. Sep 01, 1994

After taking 30 mg artichoke leaf extract tea 3 times a day, patients bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months. Dec 31, 2013

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Cholestatic jaundice during lovastatin medication has been reported. May 10, 1991

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Ferulic acid ameliorates acetaminophen-induced acute liver injury.May 04, 2022

Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury.May 16, 2022

Hepatitis associated with treatment with lovastatin has been reported. Mar 01, 1998

Liver fibrosis has been attributed to lipid lowering medications.Sep 01, 2001

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.Jul 01, 1997

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

N-acetylcysteine in the management of acute liver failure from sickle cell hepatic crisis.Jul 31, 2019

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Paeoniflorin ameliorates diabetic liver injury.Apr 24, 2022

Reversible acute hepatitis induced by rosuvastatin has been reported.Jul 01, 2008

Rosuvastatin-associated hepatitis with autoimmune features has been reported. May 01, 2005

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Liver Damage

View the Evidence:
1399 Abstracts with Liver Damage Research