Liver Damage: Drug-Induced

Name	AC	CK
NAC (N-acetyl-L-cysteine)	12	47
Silibinin	8	32
Flavonoids	16	29
Silymarin	6	28
Coenzyme Q10	4	16
Alpha-Lipoic Acid	3	14
Dandelion	6	13
Hydrogen Water	2	12
Curcumin	7	11
Ginsenosides	6	11
Vitamin C	6	11
L-Carnitine	1	10
Citrus naringin	6	9
Ginkgo biloba	5	9
Apigenin	4	8
Crocin	4	8
Fisetin	4	8
Moringa oleifera	4	7
Polyphenols	4	7
Astaxanthin	3	6
Grape Seed Extract	3	6
Licorice	3	6
Lycopene	3	6
Paeonol	3	6
Pterostilbene	3	6
Rosmarinic acid	3	6
Royal Jelly	3	6
Rutin	3	6
Saffron	3	6
Naringenin	3	5
Organosulfur Compounds	3	5
Allicin	2	4
Artichoke	2	4
Bacopa	2	4
Carbon 60	2	4
Carvacrol	2	4
Chrysin	2	4
Diosmin	2	4
EGCG (Epigallocatechin gallate)	2	4
Echinacea	2	4
Frankincense	2	4
Gotu Kola	2	4
Hesperidin	2	4
Horse Chestnut	2	4
Liquiritigenin	2	4
Paeoniflorin	2	4
Piperine	2	4
Poria cocos	2	4
Rosemary	2	4
Schisandra	2	4
Sinomenine	2	4
Thymoquinone	2	4
Urolithin A	2	4
Vitamin E	2	4
Whey	2	4
Bixin	2	3
Ferulic acid	1	3
Garlic	2	3
6-Shogaol	1	2
Acacia catechu	1	2
Achiote	1	2
Andrographis	1	2
Andrographolide	1	2
Apple Polyphenols	1	2
Asiatic Acid	1	2
Astragaloside	1	2
Baccharis trimera	1	2
Bamboo	1	2
Barberry	1	2
Bergamot	1	2
Beta-Caryophyllene	1	2
Betaine	1	2
Betanin	1	2
Biochanin A	1	2
Bitter Melon	1	2
Butterfly Pea	1	2
Carotenoids	1	2
Celery	1	2
Chlorella (Algae)	1	2
Citrus Triterpenoids	1	2
Cordyceps sinensis	1	2
Cucurbitacin B	1	2
Date Seeds	1	2
Dates	1	2
Ellagic Acid	1	2
Emodin	1	2
Eriodictyol	1	2
Fig	1	2
Formononetin	1	2
Gallic Acid	1	2
Garcinia kola	1	2
Gastrodin	1	2
Genistein	1	2
Geraniol	1	2
Gingerol	1	2
Glycyrrhizin	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Grape	1	2
Guava	1	2
Hibiscus rosa-sinensis	1	2
Honokiol	1	2
Isoflavones	1	2
Jujube	1	2
Juniper	1	2
Kaempferol	1	2
Lactobacillus casei	1	2
Lactobacillus rhamnosus GG	1	2
Lemon Balm	1	2
Lignans	1	2
Magnesium	1	2
Mango	1	2
Medicinal Mushrooms	1	2
Melatonin	1	2
Milk Thistle	1	2
Mulberry	1	2
Mululuza	1	2
Nicotinamide	1	2
Olive leaf extract	1	2
Parsley	1	2
Phellinus Linteus	1	2
Prickly Pear Cactus	1	2
Prunella vulgaris	1	2
Punicalagin	1	2
Quercetin	1	2
Raspberry	1	2
Resveratrol	1	2
Rosemaric Acid	1	2
Sage	1	2
Selenium	1	2
Sesamin	1	2
Shikonin	1	2
Sulforaphane	1	2
Taurine	1	2
Thyme	1	2
Thymol	1	2
Turmeric	1	2
Vinpocetine	1	2
Vitamin B-12	1	2
Wogonin	1	2
Xanthohumol	1	2
Zataria multiflora	1	2
Zinc	1	2
Fucoidan	1	1
Honeysuckle	1	1
Lotus	1	1
Reishi Mushroom	1	1
Tanshinone IIA	1	1
Watercress	1	1

Name	AC	CK
Acetaminophen	120	236
Paracetamol	105	204
Isoniazid	6	36
Diclofenac	7	14
Fluoxetine (trade name Prozac)	6	13
Concanavalin A	6	11
Isotretinoin	1	10
Methotrexate	6	10
Antibiotics	4	8
Statin Drugs	3	8
Cyclophosphamide	3	6
Atorvastatin	2	4
Morphine	2	4
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	4
Amiodarone	2	3
Fluconazole	1	3
Simvastatin	1	3
Tamoxifen	2	3
Deltamethrin	1	2
Methylprednisolone	1	2
Tricyclic Antidepressant (TCA)	1	2
Irinotecan	1	1

Name	AC	CK	Focus
Hyperbaric Treatment	1	2

Name	AC	CK	Focus
Vaccination: COVID-19	1	3

[+]

Acetylcysteine for the treatment of suspected remdesivir-associated acute liver Failure in COVID-19.Oct 01, 2020

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Pubmed Data : Pharmacotherapy. 2020 Oct 2. Epub 2020 Oct 2. PMID: 33006138

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Pubmed Data : Case Reports Hepatol. 2014 ;2014:697359. Epub 2014 Sep 3. PMID: 25374729

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Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447

Article Published Date : Nov 26, 2019

Study Type : Human: Case Report

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protection of taraxasterol against acetaminophen-induced liver injury.Jul 24, 2023

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Pubmed Data : Phytomedicine. 2023 Jul 25 ;116:154872. Epub 2023 May 13. PMID: 37209606

Article Published Date : Jul 24, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Rosemary extract protects liver mitochondria from oxidative damage and prevents acetaminophen-induced hepatotoxicity.Mar 02, 2023

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Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoniazid, Paracetamol

[+]

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Article Published Date : Mar 23, 2021

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective, Nrf2 activation

[+]

Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury.Dec 31, 2023

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Pubmed Data : Curr Res Food Sci. 2024 ;8:100734. Epub 2024 Apr 17. PMID: 38708102

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Cyclophosphamide

[+]

Antibiotics induced elevations of plasma bile acids in rats.Jan 19, 2017

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Pubmed Data : Toxicol Sci. 2017 Jan 20. Epub 2017 Jan 20. PMID: 28108666

Article Published Date : Jan 19, 2017

Study Type : Animal Study

Additional Links

Diseases : Antibiotic Toxicity , Liver Damage: Drug-Induced

Problem Substances : Antibiotics

[+]

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

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Pubmed Data : J Cell Biochem. 2019 May ;120(5):7482-7488. Epub 2018 Oct 30. PMID: 30378160

[+]

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

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Pubmed Data : Curr Issues Mol Biol. 2022 May 31 ;44(6):2529-2541. Epub 2022 May 31. PMID: 35735613

Article Published Date : May 30, 2022

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Antibiotic Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Cardioprotective, Hepatoprotective

Additional Keywords : Synergistic Toxicity

Problem Substances : Antibiotics, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Asiatic acid ameliorates rifampicin- and isoniazid-induced liver injury.Sep 30, 2023

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2023 Oct ;133(4):402-417. Epub 2023 Aug 1. PMID: 37272388

Problem Substances : Acetaminophen, Paracetamol

[+]

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

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Pubmed Data : Turk J Med Sci. 2021 Mar 28. Epub 2021 Mar 28. PMID: 33773522

Article Published Date : Mar 27, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

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Pubmed Data : Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bixin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Blockage of CCL5 may promote liver regeneration.Sep 03, 2019

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Pubmed Data : Cell Mol Immunol. 2019 Sep 3. Epub 2019 Sep 3. PMID: 31481754

Article Published Date : Sep 03, 2019

Study Type : Animal Study

Additional Links

Diseases : Liver Damage, Liver Damage: Drug-Induced, Liver Disease

[+]

Carvacrol exerts anti-inflammatory, anti-oxidative stress and hepatoprotective effects against diclofenac-induced liver injury.Dec 31, 2022

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Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity.Jan 31, 2023

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Pubmed Data : Heliyon. 2023 Feb ;9(2):e13727. Epub 2023 Feb 14. PMID: 36865458

Article Published Date : Jan 31, 2023

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Renoprotective

[+]

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

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[+]

Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.Oct 10, 2021

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Pubmed Data : Nanomedicine (Lond). 2021 Oct 11. Epub 2021 Oct 11. PMID: 34632809

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Pubmed Data : Drug Chem Toxicol. 2022 May ;45(3):1180-1187. Epub 2020 Aug 24. PMID: 32838567

Article Published Date : Apr 30, 2022

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Hepatoprotective

[+]

Escin protects against acetaminophen-induced liver injury.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(8):5170-5182. Epub 2019 Aug 15. PMID: 31497232

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model.Jan 20, 2024

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Pubmed Data : Pharmacogn Mag. 2017 Jan-Mar;13(49):108-113. PMID: 28216892

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Juniper

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Fisetin attenuates paracetamol-induced hepatotoxicity by regulating CYP2E1 enzyme.Dec 31, 2022

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Pubmed Data : Oncotarget. 2019 May 28 ;10(37):3472-3490. Epub 2019 May 28. PMID: 31191820

Article Published Date : May 27, 2019

Grape seed extract treatment may serve as a potential therapeutic agent in carbamazepine-induced hepatotoxicity/ dysfunction.Dec 31, 2019

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Pubmed Data : Toxicol Rep. 2020 ;7:1592-1596. Epub 2020 Nov 24. PMID: 33304829

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

[+]

Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury.Sep 22, 2020

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Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):8297-8308. PMID: 32909594

Article Published Date : Sep 22, 2020

Study Type : Animal Study

Additional Links

Substances : Guava

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

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Pubmed Data : Cureus. 2023 Jan ;15(1):e33272. Epub 2023 Jan 2. PMID: 36606101

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Pubmed Data : Arch Razi Inst. 2023 Feb ;78(1):419-425. Epub 2023 Feb 28. PMID: 37312722

Article Published Date : Jan 31, 2023

Study Type : Animal Study

Additional Links

Substances : Vitamin B-12

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen

[+]

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

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Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139

Article Published Date : Jul 14, 2018

Study Type : Animal Study

Additional Links

Substances : Poria cocos

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.Dec 05, 2011

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Pubmed Data : Molecules. 2011 Dec 6 ;16(12):10134-45. Epub 2011 Dec 6. PMID: 22146374

Article Published Date : Dec 05, 2011

Study Type : Animal Study

Additional Links

Substances : Butterfly Pea, Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective potential of diosmin against hepatotoxic effect of isoniazid and rifampin.Dec 31, 2022

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Pubmed Data : Hum Exp Toxicol. 2023 ;42:9603271221149199. PMID: 36592122

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Diosmin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

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Pubmed Data : World J Gastroenterol. 2015 Apr 14 ;21(14):4195-209. PMID: 25892869

Article Published Date : Apr 13, 2015

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model. Sep 30, 2013

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Pubmed Data : Hum Exp Toxicol. 2013 Oct ;32(10):1107-16. Epub 2013 Aug 7. PMID: 23925941

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Pubmed Data : Mol Biol Rep. 2020 Jan 25. Epub 2020 Jan 25. PMID: 31983015

Limonin ameliorates acetaminophen-induced hepatotoxicity.Mar 31, 2020

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Pubmed Data : Phytomedicine. 2020 Apr ;69:153211. Epub 2020 Mar 20. PMID: 32259676

Article Published Date : Mar 31, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus Triterpenoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation, SIRT1 Activator

Problem Substances : Acetaminophen, Paracetamol

[+]

Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity.May 01, 2022

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Pubmed Data : Drug Chem Toxicol. 2022 May 2:1-9. Epub 2022 May 2. PMID: 35502492

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Pubmed Data : Environ Sci Pollut Res Int. 2018 Sep 24. Epub 2018 Sep 24. PMID: 30251044

Article Published Date : Sep 23, 2018

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

[+]

Lycopene is a natural compound that was able to inhibit the production of ROS and mitigate the damage caused by acetaminophen.Jan 31, 2017

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Pubmed Data : Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599

Article Published Date : Jan 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carotenoids, Lycopene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Antioxidants, CAROTENOIDS, Hepatoprotective, Liver Damage: Drug-Induced, lycopene, Matrix metalloproteinase-2 (MMP-2) inhibitor, oxidative stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.Jan 31, 2017

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Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152

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Pubmed Data : Nutrients. 2022 Feb 28 ;14(5). Epub 2022 Feb 28. PMID: 35268000

Article Published Date : Feb 27, 2022

Study Type : Animal Study

Additional Links

Substances : Dates

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

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Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury.Aug 31, 2022

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Pubmed Data : Phytomedicine. 2022 Sep ;104:154311. Epub 2022 Jul 6. PMID: 35843188

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Echinacea

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Possible protective role of whey protein on the rat's liver tissues treated with nandrolone decanoate.Dec 31, 2017

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Pubmed Data : Food Chem Toxicol. 2017 Nov ;109(Pt 1):28-37. Epub 2017 Aug 25. PMID: 28847761

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of boswellic acids against doxorubicin-induced hepatotoxicity.Dec 31, 2017

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8296451. Epub 2018 Feb 6. PMID: 29541348

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Frankincense

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Additional Keywords : Drug: Doxorubicin

[+]

Protective effect of dandelion leaf water extracts on APAP-induced liver injury in rats and its mechanism.May 30, 2022

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Pubmed Data : Phytother Res. 2021 Jan 18. Epub 2021 Jan 18. PMID: 33462870

Article Published Date : Jan 17, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Gotu Kola

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

[+]

Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity.Jun 30, 2016

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Pubmed Data : Can J Physiol Pharmacol. 2016 Jul ;94(7):739-44. Epub 2016 Mar 9. PMID: 27124106

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene, Silymarin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Beta-Caryophyllene, Hepatoprotective, Liver Damage: Drug-Induced, Plant Extracts, SILYMARIN

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Protective effects of crocin against methotrexate-induced hepatotoxicity.Dec 31, 2022

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Pubmed Data : Int J Biomed Sci. 2016 Jun ;12(2):71-8. PMID: 27493593

Article Published Date : May 31, 2016

Study Type : Animal Study

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Substances : Sage

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Essential Oils

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Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury.Jun 30, 2019

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Pubmed Data : J Pharmacol Sci. 2019 Jul ;140(3):248-254. Epub 2019 Jul 24. PMID: 31400930

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Pubmed Data : Mediators Inflamm. 2016 ;2016:2748367. Epub 2016 May 16. PMID: 27293314

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Shikonin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Autophagy Inhibitors, Hepatoprotective

Problem Substances : Concanavalin A

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Silibinin's effects against methotrexate-induced hepatotoxicity in adjuvant-induced arthritis rat model. Mar 27, 2024

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The potential protective role of naringenin against dasatinib-induced hepatotoxicity.Jun 22, 2023

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Pubmed Data : Pharmaceuticals (Basel). 2023 Jun 23 ;16(7). Epub 2023 Jun 23. PMID: 37513833

Article Published Date : Jun 22, 2023

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

The present study demonstrates paeonol has a protective ability against acetaminophen-induced hepatotoxicity.Dec 31, 2015

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Pubmed Data : PLoS One. 2016 ;11(5):e0154375. Epub 2016 May 4. PMID: 27144271

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Pubmed Data : Medicina (Kaunas). 2023 Oct 12 ;59(10). Epub 2023 Oct 12. PMID: 37893532

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Pubmed Data : Int J Biol Sci. 2022 ;18(5):2146-2162. Epub 2022 Feb 28. PMID: 35342347

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Urolithin A

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Vinpocetine attenuates fluoxetine-induced liver damage.Nov 30, 2021

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Pubmed Data : Curr Mol Pharmacol. 2021 May 25. Epub 2021 May 25. PMID: 34042041

Article Published Date : May 24, 2021

Study Type : In Vitro Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Methotrexate

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Drugs like amiodarone, tamoxifen, irinotecan, methotrexate, valproic acid and glucocorticoids have been recognized to be associated with steatosis.Feb 28, 2017

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Pubmed Data : Nutrients. 2024 Jun 13 ;16(12). Epub 2024 Jun 13. PMID: 38931214

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Pubmed Data : Molecules. 2022 Jun 23 ;27(13). Epub 2022 Jun 23. PMID: 35807275

Article Published Date : Jun 22, 2022

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

In vitro protective effect of ascorbic acid against antibiotic-induced hepatotoxicity.Feb 03, 2019

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Pubmed Data : Curr Drug Discov Technol. 2019 Feb 4. Epub 2019 Feb 4. PMID: 30714529

Article Published Date : Feb 03, 2019

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Antibiotic Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

[+]

Isolation and characterization of a hepatoprotective polysaccharide from Lonicera caerulea fruit against APAP-induced acute liver injury.Jun 24, 2024

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Pubmed Data : Int J Biol Macromol. 2024 Jun 25 ;275(Pt 1):133426. Epub 2024 Jun 25. PMID: 38936574

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Pubmed Data : Autophagy. 2023 Feb 24:1-17. Epub 2023 Feb 24. PMID: 36779633

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View the Evidence: 273 Abstracts with Liver Damage: Drug-Induced Research

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Acetylcysteine for the treatment of suspected remdesivir-associated acute liver Failure in COVID-19.Oct 01, 2020

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.Dec 15, 2009

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms. Jul 01, 2005

NAC has a therapeutic effect on hepatotoxicity in children being treated with chemotherapeutic agents.Mar 31, 2020

NAC should be considered in management of anti-tuberculosis drug induced liver injury.Aug 25, 2020

Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients.Apr 15, 2021

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.Mar 05, 2010

Silibinin could be beneficial in preventing drug-induced liver injury in tuberculosis treatments. Dec 31, 2014

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

The effect of acetyl-L-carnitine, alpha-lipoic acid, and coenzyme Q10 combination in preventing anti-tuberculosis drug-induced hepatotoxicity.Dec 31, 2020

The effect of silymarin on liver enzymes in patients taking isotretinoin.Feb 29, 2020

A case of hepatotoxicity after receiving a COVID-19 vaccine Nov 30, 2021

A case report of fluoxetine-induced Stevens-Johnson syndrome and liver injury.Jan 31, 2019

After taking 30 mg artichoke leaf extract tea 3 times a day, patients bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months. Dec 31, 2013

Cholestatic jaundice during lovastatin medication has been reported. May 10, 1991

Farrerol ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2018

Ferulic acid ameliorates acetaminophen-induced acute liver injury.May 04, 2022

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Protection of taraxasterol against acetaminophen-induced liver injury.Jul 24, 2023

Rosemary extract protects liver mitochondria from oxidative damage and prevents acetaminophen-induced hepatotoxicity.Mar 02, 2023

Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation has been reported. Sep 01, 2008

Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity.Jul 25, 2020

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

Pterostilbene-loaded soluplus/poloxamer 188 mixed micelles for protection against acetaminophen-induced acute liver injury.Feb 05, 2023

Purple grape juices prevent pentylenetetrazol-induced oxidative damage in the liver and serum of Wistar rats.Jan 31, 2013

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.Nov 01, 2011

A crude aqueous leafy extract of M. indica possesses hepatoprotective effects.Jun 30, 2022

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products.Dec 31, 2022

Administration of Zataria multiflora extract and carvacrol could reduce the oxidative damage in the rat liver induced by doxorubicin.Nov 30, 2018

Allicin mitigates hepatic injury following cyclophosphamide administration.Mar 23, 2021

Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury.Dec 31, 2023

Antibiotics induced elevations of plasma bile acids in rats.Jan 19, 2017

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity.Sep 30, 2023

Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.Jan 31, 2019

Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats.Feb 10, 2020

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Apigenin attenuates acetaminophen-induced hepatotoxicity. Dec 31, 2019

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

Apigenin significantly increases the enzyme antioxidant defence mechanisms in paracetamol-induced hepatotoxicity.Mar 01, 2017

Apple polyphenols exert protective effects against Con A-induced immunological liver injury.Aug 23, 2016

Ascorbic acid ameliorates cardiac and hepatic toxicity induced by azithromycin-etoricoxib drug interaction.May 30, 2022

Asiatic acid ameliorates rifampicin- and isoniazid-induced liver injury.Sep 30, 2023

Astaxanthin from haematococcus pluvialis ameliorates the chemotherapeutic drug doxorubicin induced liver injury. May 13, 2020

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

Astragaloside IV ameliorates cisplatin-induced liver injury by modulating ferroptosis-dependent pathways.Jun 27, 2024

Atorvastatin may contribute to hepatopathy through suppressing oxidized and reduce coenzyme q10 and mitochondrial function in the liver. Apr 20, 2012

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

Baicalin provides protection against fluoxetine-induced hepatotoxicity.Apr 26, 2022

Berberis integerrima hydro-alcoholic root extract ant its constituent berberine protect against cisplatin-induced nephro- and hepato-toxicity.Apr 11, 2022

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure.Jan 10, 2020

Betaine supplementation attenuates hepatic injury mediated by cisplatin.Oct 31, 2019

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Betulinic acid can be used as an effective agent in the prevention and treatment of acute liver diseases.Mar 27, 2021

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

Blockage of CCL5 may promote liver regeneration.Sep 03, 2019

Carvacrol exerts anti-inflammatory, anti-oxidative stress and hepatoprotective effects against diclofenac-induced liver injury.Dec 31, 2022

Chemoprotective effect of Vernonia amygdalina Del. (Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity.Dec 31, 2015

Chlorella protective effect on acetaminophen-induced liver toxicity.Dec 31, 2019

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress.Nov 06, 2022

Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.Nov 17, 2019

Co-administration of fresh grape fruit juice and bergamottin prevented paracetamol induced hepatotoxicity.Dec 31, 2014

Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity.Jan 31, 2023

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.Dec 31, 2021

Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice.Aug 31, 2018

Liver Damage: Drug-Induced

View the Evidence:
273 Abstracts with Liver Damage: Drug-Induced Research