Lung Cancer: Metastatic

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18 Substances Researched for Lung Cancer: Metastatic
NameACCKFocus
Water: Deuterium Depleted220Locked
Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)25Locked
Agrimony13Locked
Fucoidan23Locked
Graviola 13Locked
Lycopene23Locked
Bisdemethoxycurcumin22Locked
Curcumin22Locked
Honokiol12Locked
Pomegranate12Locked
Seaweed: Brown 12Locked
Vitamin C12Locked
Vitamin K12Locked
Wogonin12Locked
Arctigenin11Locked
Betulinic acid11Locked
Gac11Locked
Pterostilbene11Locked

View the Evidence:
21 Abstracts with Lung Cancer: Metastatic Research

[+]

DDW was administered as an oral anticancer agent in addition to conventional therapy, and noticeably prolonged the survival time of all 4 lung cancer patients with brain metastasis.Aug 31, 2008

Pubmed Data : Integr Cancer Ther. 2008 Sep ;7(3):172-81. PMID: 18815148
Article Published Date : Aug 31, 2008
Study Type : Human Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-Tumor, Antiproliferative , Chemopreventive, Chemotherapeutic
Additional Keywords : Significant Treatment Outcome
[+]

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Cancer. 2013 ;65(2):240-6. PMID: 23441611
Article Published Date : Dec 31, 2012
Study Type : Animal Study, Human Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Carcinoma: Non-Small-Cell Lung, Carcinoma: Small Cell Lung, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Gene Expression Regulation, Proto-oncogene
[+]

a patient suffering from HCC with lung metastasis demonstrated regression of metastatic disease while consuming guyabano fruit extract in the absence of conventional chemotherapy. Feb 08, 2015

Pubmed Data : J Diet Suppl. 2015 Feb 9. Epub 2015 Feb 9. PMID: 25664807
Article Published Date : Feb 08, 2015
Study Type : Human: Case Report
Additional Links
Substances : Graviola
Diseases : Liver Cancer, Liver Cancer: Metastatic, Lung Cancer: Metastatic
Pharmacological Actions : Antineoplastic Agents
Additional Keywords : Plant Extracts
[+]

A quick response of advanced cancer to chemoradiation therapy with antineoplastons has been reported.May 01, 1998

Pubmed Data : Oncol Rep. 1998 May-Jun;5(3):597-600. PMID: 9538158
Article Published Date : May 01, 1998
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)
Diseases : Glioblastoma, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Chemotherapeutic
[+]

The use of agrimonia led to rapid bone repair in a patient with metastatic lung cancer.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Sep ;12(3):2023-2027. Epub 2016 Jul 18. PMID: 27602132
Article Published Date : Aug 31, 2016
Study Type : Human: Case Report
Additional Links
Substances : Agrimony
Diseases : Cancer Metastasis, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Antiproliferative
Additional Keywords : Bone Regeneration
[+]

"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."Mar 01, 2005

Pubmed Data : Oncol Rep. 2005 Mar ;13(3):389-95. PMID: 15706406
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)
Diseases : Cancer Metastasis, Colon Cancer, Lung Cancer: Metastatic, Post-Operative Lung Metastasis of Colon Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Cell cycle arrest
[+]

A polysaccharide from Punica granatum has an inhibitory effect on metastasis. May 24, 2017

Pubmed Data : Int J Biol Macromol. 2017 May 25. Epub 2017 May 25. PMID: 28552725
Article Published Date : May 24, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Cancer Metastasis, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic
Additional Keywords : Anti-metastatic, Cancer Metastasis, Lung Cancer: Metastatic, pomegranate
[+]

Fucoidan functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.Aug 23, 2021

Pubmed Data : Int J Mol Sci. 2021 Aug 24 ;22(17). Epub 2021 Aug 24. PMID: 34502035
Article Published Date : Aug 23, 2021
Study Type : Animal Study
Additional Links
Substances : Fucoidan, Seaweed: Brown
Diseases : Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

Honokiol could provide novel chemopreventive or therapeutic options for preventing both lung tumor progression and lung cancer metastasis.Jan 31, 2017

Pubmed Data : Cancer Prev Res (Phila). 2017 Feb ;10(2):133-141. Epub 2016 Nov 14. PMID: 27849557
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Cancer Metastasis, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Chemopreventive, STAT3 Inhibitor
[+]

Lycopene inhibits experimental metastasis of human hepatoma in athymic mice. Mar 01, 2008

Pubmed Data : J Nutr. 2008 Mar ;138(3):538-43. PMID: 18287363
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Cancer Metastasis, Liver Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor A Inhibitor
[+]

Vitamin C in combination with vitamin K3 inhibits primary tumor growth and exhibits antimetastastic potential in vivo through attenuated tumor invasion and proliferation.Dec 31, 2010

Pubmed Data : Nutr Cancer. 2011 ;63(7):1036-43. Epub 2011 Sep 2. PMID: 21888506
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin K
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Disease Regression, Dose Response
[+]

Wogonin suppresses tumor cells migration in inflammatory microenvironment by inactivating STAT3 signaling.Jun 28, 2014

Pubmed Data : Mol Carcinog. 2014 Jun 29. Epub 2014 Jun 29. PMID: 24976450
Article Published Date : Jun 28, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic
Additional Keywords : Tumor Microenvironment
[+]

"Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways."Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(11):e50624. Epub 2012 Nov 30. PMID: 23226337
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Chemopreventive, NF-kappaB Inhibitor
[+]

A derivative of betulinic acid may be a viable treatment for lung cancer metastasis, either alone or in combination, without causing damage to normal cells.May 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 May 30 ;6(15):13671-87. PMID: 25909174
Article Published Date : May 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Bisdemethoxycurcumin inhibits Wnt/β-catenin pathway by increasing WIF-1 expression, which subsequently leads to suppression of TGF-β1-induced EMT migration.Dec 31, 1969

Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin, Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin pathway down-regulation
[+]

Curcumin is a multi-targeting agent, simultaneously activating the tumor suppressor p53/p73 pathways and inhibiting pro-apoptotic p-AKT and Bcl-2 levels. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0124218. Epub 2015 Apr 24. PMID: 25910231
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung, Head and Neck Cancer, Head and Neck Neoplasms, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

ECMS might be a promising candidate for the therapy of the non-small cell lung cancer by regulating multiple molecular targets. Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(1):149-66. Epub 2015 Feb 4. PMID: 25649746
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Gac
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Pterostilbene possesses potency in both preventing and treating lung metastasis of lung cancer cells.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Hematol Oncol. 2017 Mar 21 ;10(1):72. Epub 2017 Mar 21. PMID: 28327179
Article Published Date : Mar 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

These findings provided direct evidence that Bisdemethoxycurcumin inhibits 95D-cell migration and invasion.Oct 31, 2015

Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7603-8. Epub 2015 Sep 24. PMID: 26459909
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Autophagy Up-regulation
[+]

This article reviews data on the cancer preventive activities of lycopene and possible mechanisms involved.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2011 ;3(2):2333-57. Epub 2011 May 11. PMID: 24212813
Article Published Date : Dec 31, 2010
Study Type : Review
Additional Links
Substances : Lycopene
Diseases : Lung Cancer, Lung Cancer: Metastatic, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Nrf2 activation, Phase II Detoxification Enzyme Inducer
[+]

This data demonstrates the anti-metastatic activity of arctigenin in a lung cancer model.Nov 17, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Nov 18 ;493(2):934-939. Epub 2017 Sep 23. PMID: 28951214
Article Published Date : Nov 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic

Copyright: Eraxion / 123RF Stock Photo

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