Melanoma

Name	AC	CK
Coffee	4	60
Curcumin	37	45
Vitamin D	7	25
Chlorogenic Acid	1	20
Sulforaphane	5	16
Vitamin C	10	15
Ginsenosides	10	13
EGCG (Epigallocatechin gallate)	8	11
Resveratrol	9	11
Apigenin	4	10
Broccoli Sprouts	1	10
Caffeine	1	10
Lichens	5	9
Mistletoe	4	9
Quercetin	6	9
Chaga Mushroom (Inonotus obliquus)	4	7
Indole-3-Carbinol	6	7
Phloretin	3	7
Tocotrienol: Delta	3	7
Cannabinoids	4	6
Green Tea	5	6
Pterostilbene	4	6
Rosemary	2	6
Zerumbone	2	6
Anthocyanins	4	5
Fisetin	4	5
Flavonoids	4	5
Homeopathic Medicine: All	3	5
Parthenolide	4	5
Polyphenols	4	5
Berberine	4	4
Fucoidan	4	4
Phellinus Linteus	2	4
Thymoquinone	3	4
Antrodia camphorata	2	3
Bamboo	2	3
Cannabinoids: Synthetic	2	3
Catechin	2	3
Chrysin	2	3
Cinnamon	2	3
Collagen	2	3
Essential Oils: Unspecified	2	3
Gallic Acid	2	3
Genistein	3	3
Luteolin	2	3
Nexrutine (Phellodendrom)	2	3
Oleuropein	2	3
Raspberry	2	3
Reishi Mushroom	2	3
Whey	2	3
Acai	1	2
Angelica	1	2
Apple	1	2
Baicalein	2	2
Benzyl isothiocyanate	2	2
Beta-Elemene	2	2
Broccoli	1	2
Cannabis	2	2
Carnosic Acid	2	2
Carnosol	2	2
Carrot	1	2
Cordyceps sinensis	1	2
Crocin	1	2
Cruciferous Vegetables	2	2
Cucurbitacin B	1	2
Delphinidin	1	2
Diosmin	1	2
Ellagic Acid	1	2
Emodin	2	2
Flaxseed	1	2
Ginseng	1	2
Hibiscus sabdariffa	2	2
Holy Basil	1	2
Isoliquiritigenin	2	2
Kaempferol	1	2
Lemon Peel	1	2
Moringa oleifera	2	2
Oleanolic acid	1	2
Olive Oil	2	2
Olive leaf extract	1	2
Phenethyl isothiocyanate	2	2
Phyllanthus amarus	2	2
Phyllanthus niruri (Stonebreaker)	2	2
Phyllanthus urinaria	2	2
Piceatannol	2	2
Pomegranate	1	2
Prickly Pear Cactus	1	2
Red Wine Extract	1	2
Sage	2	2
Sandalwood	2	2
Soy Protein	1	2
Tanshinone IIA	1	2
Tea Tree	2	2
Thyme	2	2
Tocotrienol: Alpha	1	2
Triptolide	1	2
Turkey Tail Mushroom	1	2
Vitamin A	1	2
Vitamin E: Gamma-tocotrienol	2	2
Wheat Grass	1	2
Adlay	1	1
Allicin	1	1
Aloe Vera	1	1
Ashwagandha	1	1
Asiatic Acid	1	1
Bai Zhu	1	1
Bay leaf	1	1
Bee Propolis	1	1
Bee Venom	1	1
Bloodroot	1	1
Blueberry	1	1
Bromelain	1	1
Caffeic Acid	1	1
Cannabidiol	1	1
Chokeberry	1	1
Cinnamaldehyde	1	1
Damnacanthal	1	1
Dandelion	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Diosgenin	1	1
Eucalyptus	1	1
Evening Primrose Oil	1	1
Feverfew	1	1
Garlic	1	1
Geum japonicum	1	1
Ginger	1	1
Goldenseal	1	1
Gotu Kola	1	1
Grape	1	1
Gymnema Sylvestre	1	1
Hibiscus rosa-sinensis	1	1
Honokiol	1	1
Huaier (Trametes robiniophila murr)	1	1
Inositol Hexaphosphate	1	1
Licorice	1	1
Loquat Leaves	1	1
Magnolol	1	1
Marigold	1	1
Medicinal Mushrooms	1	1
Melatonin	1	1
Modified Citrus Pectin	1	1
Naringenin	1	1
Nettle	1	1
Okra	1	1
Oleocanthal	1	1
P-Coumaric Acid	1	1
Pear	1	1
Piperidines	1	1
Polygonatum cyrtonema	1	1
Potato	1	1
Psychedelics:All	1	1
Rice Bran	1	1
Sesame Seed Oil	1	1
Shikonin	1	1
Sophora Flavescens	1	1
Squash: Butternut	1	1
Syrian rue	1	1
Tocotrienol: Gamma	1	1
Tocotrienols	1	1
Ursolic Acid	1	1
Verbascoside	1	1
Vitamin E	1	1
Vitamin K	1	1
Walnut	1	1
Wasabi	1	1
White Button Mushroom	1	1
Wormwood	1	1

Name	AC	CK
Eszopiclone	1	20
Hypnotic Drugs	1	20
Ramelteon	1	20
Zaleplon	1	20
Zolpidem (trade name Ambien)	1	20
Pesticides	2	12
Dl-alpha-tocopherol acetate	1	10
Glyphosate	1	10
Meat	1	10
Mineral Oil	1	10
Statin Drugs	1	10
Cisplatin	1	2
Doxorubicin	1	2
Paclitaxel	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	1

Name	AC	CK
Sunlight exposure	3	12
Gerson Therapy	1	10
Light-Emitting Diodes (LEDs) Therapy	1	5
Dietary Modification: Low Carbohydrate	1	2
Photodynamic therapy	1	2
Laser Treatment: Low-Level	1	1
Light Therapy	1	1

Name	AC	CK	Focus
Biopsy Procedure: Sentinel Lymph-Node	1	1
Biopsy: Various Tissue	1	1

[+]

Coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma, but increased lung cancer risk.Sep 25, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Sep 26 ;6:33711. Epub 2016 Sep 26. PMID: 27665923

Pubmed Data : Melanoma Res. 2002 Feb;12(1):83-90. PMID: 11828262

Article Published Date : Feb 01, 2002

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Melanoma

Problem Substances : Dl-alpha-tocopherol acetate

[+]

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

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Pubmed Data : Cancer Prev Res (Phila). 2018 Apr 24. Epub 2018 Apr 24. PMID: 29691233

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2017 May ;13(5):3787-3792. Epub 2017 Mar 23. PMID: 28521479

Article Published Date : Apr 30, 2017

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Melanoma, Vitamin D Deficiency

Additional Keywords : Risk Factors

[+]

Red and processed meat intake was inversely associated with melanoma risk in these two cohorts.Apr 22, 2018

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Pubmed Data : J Am Acad Dermatol. 2018 Apr 23. Epub 2018 Apr 23. PMID: 29698709

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Pubmed Data : Am J Clin Nutr. 2019 Aug 5. Epub 2019 Aug 5. PMID: 31380561

Article Published Date : Aug 05, 2019

Study Type : Human Study

Additional Links

Diseases : Basal Cell Carcinoma, Melanoma, Skin Cancer

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Anti-cancer, Anticarcinogenic Agents

[+]

The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides.Mar 31, 2016

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Pubmed Data : J Occup Environ Med. 2016 Apr ;58(4):370-5. PMID: 27058477

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Pubmed Data : PLoS One. 2015 ;10(7):e0132439. Epub 2015 Jul 15. PMID: 26176704

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Pubmed Data : Cancer Immunol Immunother. 2016 Jan ;65(1):83-92. Epub 2015 Dec 8. PMID: 26646850

Article Published Date : Dec 31, 2015

Study Type : Human In Vitro, In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

[+]

The present study shows that lichen compounds demonstrated strong antioxidant, antimicrobial, and anticancer properties.Oct 14, 2012

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Pubmed Data : Phytomedicine. 2012 Oct 15 ;19(13):1166-72. Epub 2012 Aug 22. PMID: 22921748

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Pubmed Data : Homeopathy. 2016 Feb ;105(1):109-18. Epub 2015 Sep 26. PMID: 26828006

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Chemopreventive, Chemotherapeutic

[+]

An isocaloric carbohydrate restriction diet and natural AMPK activating agents induce synergistic anticancer effects.Mar 18, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Cancer Prev. 2015 Mar 19. Epub 2015 Mar 19. PMID: 25747515

Article Published Date : Mar 18, 2015

Study Type : In Vitro Study, Transgenic Animal Study

Additional Links

Substances : Catechin , Curcumin, Quercetin, Resveratrol

Diseases : Liver Cancer, Melanoma

Therapeutic Actions : Dietary Modification: Low Carbohydrate

Pharmacological Actions : AMP-activated protein kinase modulation , Antiproliferative , Chemopreventive, Interleukin-6 Downregulation, SIRT1 Activator

Additional Keywords : Diet Induced Tumor Suppression

[+]

Angelica sinensis has therapeutic effect against melanoma cells in the mouse experimental model.Mar 01, 2007

Article Published Date : May 29, 2006

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Melanoma

Pharmacological Actions : Immunostimulatory

[+]

Arctium lappa extract suppresses inflammation and inhibits melanoma progression.Jul 28, 2019

Pubmed Data : J Surg Res. 2019 Mar ;235:210-215. Epub 2018 Oct 30. PMID: 30691796

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Chemopreventive

[+]

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

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Dietary oleuropein inhibits tumor angiogenesis and lymphangiogenesis in the B16F10 melanoma allograft model.Mar 30, 2017

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Pubmed Data : Oncotarget. 2017 Mar 31. Epub 2017 Mar 31. PMID: 28410190

Article Published Date : Mar 30, 2017

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : High Fat Diet, Melanoma

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor D Inhibitor

[+]

Diosmin has a synergistic effect with interferon-alpha in inhibiting metastatic pulmonary melanoma. Jun 01, 2009

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Pubmed Data : Cancer Biother Radiopharm. 2009 Jun;24(3):347-52. PMID: 19538057

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2019 May 28 ;10(37):3472-3490. Epub 2019 May 28. PMID: 31191820

Article Published Date : May 27, 2019

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Pubmed Data : Oncol Res. 2006 ;16(5):211-6. PMID: 17294801

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Pubmed Data : Food Funct. 2015 Sep 2 ;6(9):3022-34. PMID: 26200777

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104

Article Published Date : Apr 14, 2011

Pubmed Data : J Photochem Photobiol B. 2017 Jan ;166:301-310. Epub 2016 Dec 9. PMID: 28024281

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Acai

Diseases : Melanoma

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Antiproliferative , Photosensitizing Agents

Additional Keywords : Plant Oils

[+]

Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol.Jan 27, 2017

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Pubmed Data : J Control Release. 2017 Jan 28 ;246:79-87. Epub 2016 Dec 18. PMID: 27993600

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2010 Jun 10 ;5(6):e11051. Epub 2010 Jun 10. PMID: 20548792

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Pubmed Data : Cancers (Basel). 2021 Jan 29 ;13(3). Epub 2021 Jan 29. PMID: 33572775

Article Published Date : Jan 28, 2021

Study Type : Animal Study

Additional Links

Substances : Xanthohumol

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Aloin promotes cell apoptosis by targeting HMGB1-TLR4-ERK axis in human melanoma cells.Dec 31, 2019

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Pubmed Data : Biosci Biotechnol Biochem. 2010;74(4):753-8. PMID: 20445320

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : White Button Mushroom

Diseases : Melanoma, Pigmentation Disorders

[+]

A comprehensive assessment of apigenin as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound.Apr 15, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Apr 16 ;11(4). Epub 2019 Apr 16. PMID: 30995771

[+]

Alpha-santalol, an active component of sandalwood oil, has chemopreventive effects on skin cancer.Jan 01, 2010

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Pubmed Data : BMC Res Notes. 2010;3:220. Epub 2010 Aug 3. PMID: 20682067

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Sandalwood

Diseases : Epidermoid Cyst, Melanoma, Skin Cancer

Pharmacological Actions : Cell cycle arrest

[+]

An extract of evening primrose (O. paradoxa) exhibits pro-oxidative and pro-apoptic against human skin melanoma cells. Sep 23, 2009

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Pubmed Data : J Agric Food Chem. 2009 Sep 23;57(18):8282-9. PMID: 19694434

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : SAGE Open Med. 2017 ;5:2050312116689519. Epub 2017 Feb 10. PMID: 28293423

Antioxidative and anti-melanogenic activities of bamboo stems.Jan 29, 2018

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Pubmed Data : Oncol Lett. 2018 Nov ;16(5):6039-6044. Epub 2018 Sep 3. PMID: 30333875

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Damnacanthal

Diseases : Melanoma

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

Apoptotic effect of astragalin in melanoma skin cancers.Sep 30, 2017

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Pubmed Data : Phytother Res. 2017 Oct ;31(10):1614-1620. Epub 2017 Aug 15. PMID: 28809055

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Pubmed Data : Pharmacol Res. 2020 Feb 11:104689. Epub 2020 Feb 11. PMID: 32057895

Article Published Date : Feb 10, 2020

Study Type : Review

Additional Links

Substances : Astaxanthin

Diseases : Colorectal Cancer, Gastric Cancer, Melanoma

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Apoptotic

[+]

Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells.Jun 13, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Jun 14 ;136(1):279-82. Epub 2011 Apr 16. PMID: 21524699

Article Published Date : Jun 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : Bai Zhu

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Available data so far, justify the use of Fermented wheat germ extract as a non-prescription medical nutriment for cancer patients.Sep 04, 2011

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Betulinic acid shows anticancer activity against equine melanoma cells and permeates isolated equine skin in vitro.Feb 04, 2020

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Chemovirotherapy of malignant melanoma with a targeted and armed oncolytic measles virus.Mar 31, 2013

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Pubmed Data : J Invest Dermatol. 2013 Apr ;133(4):1034-42. Epub 2012 Dec 6. PMID: 23223133

Article Published Date : Mar 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Viruses: Beneficial

Diseases : Melanoma, Skin Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Chemovirotherapy

[+]

Chinese propolis exerts anti-proliferation effects in human melanoma cells.Aug 25, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Aug 26 ;10(9). Epub 2018 Aug 26. PMID: 30149677

Article Published Date : Aug 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Bee Propolis

Diseases : Melanoma, Skin Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

[+]

Combination of asiatic acid and naringenin modulates NK cell anti-cancer immunity.Jun 21, 2018

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Pubmed Data : Mol Ther. 2018 Jun 22. Epub 2018 Jun 22. PMID: 30017880

Article Published Date : Jun 21, 2018

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid, Naringenin

Diseases : Lung Cancer, Melanoma

Pharmacological Actions : Antiproliferative , Immunomodulatory

[+]

Crocin elicited marked anti-metastatic potential by regulating the metastasis induced biomarkers.Dec 31, 2016

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Pubmed Data : J Biomed Res. 2017 11 1. Epub 2017 Nov 1. PMID: 29219852

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Saffron

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic

[+]

Crude extracts and phytochemicals derived from H. sabdariffa has antimicrobial, antiparasitic, and anticancer properties.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ceska Slov Farm. 2016 ;65(1):10-14. PMID: 27118499

Article Published Date : Dec 31, 2015

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Pubmed Data : Phytomedicine. 2019 Jan ;52:117-128. Epub 2018 Sep 28. PMID: 30599890

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Pubmed Data : Mol Biol Rep. 2015 Jan ;42(1):267-75. Epub 2014 Sep 28. PMID: 25262359

[+]

Cytotoxic activity of high dose ascorbic acid is enhanced by 2-deoxy-d-glucose in glycolytic melanoma cells.Feb 08, 2021

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Pubmed Data : Biochem Biophys Res Commun. 2021 Feb 9 ;546:90-96. Epub 2021 Feb 9. PMID: 33578294

Article Published Date : Feb 08, 2021

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

[+]

Cytotoxic effect of Ginkgo biloba kernel extract on HCT116 and A2058 cancer cell lines.Aug 31, 2020

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Pubmed Data : J BUON. 2020 Jan-Feb;25(1):485-490. PMID: 32277673

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Daidzein

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation

[+]

Dandelion root has a potent action against chemoresistant melanoma without toxicity to healthy cells.Jan 01, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2011 ;2011:129045. Epub 2010 Dec 30. PMID: 21234313

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicines (Basel). 2019 Jun 27 ;6(3). Epub 2019 Jun 27. PMID: 31252639

Article Published Date : Jun 26, 2019

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Melanoma

Pharmacological Actions : Antiproliferative

Additional Keywords : Gene Expression

[+]

Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma.Mar 31, 2018

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Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 Apr 1:1-12. Epub 2018 Apr 1. PMID: 29607740

Article Published Date : Mar 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Chrysin, Curcumin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : Oncotarget. 2015 Jul 31. Epub 2015 Jul 31. PMID: 26299806

Article Published Date : Jul 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Melanoma

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: Sorafenib

[+]

Fisetin induces apoptosis of uveal melanoma cells selectively.Jan 30, 2018

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Pubmed Data : Environ Toxicol. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29383865

Article Published Date : Jan 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Melanoma

Pharmacological Actions : Apoptotic

Additional Keywords : Selective Cytotoxicity

[+]

FKBP51 promotes melanoma growth, metastasis and angiogenesis, and Interleukin (IL)-8 plays a key role in these processes.May 25, 2015

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Pubmed Data : Br J Cancer. 2015 May 26 ;112(11):1772-81. Epub 2015 May 5. PMID: 25942396

Article Published Date : May 25, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Melanoma, Melanoma: Metastasis

[+]

Fucoidan exhibits anti-tumor activity against breast cancer and melanoma cells.Mar 31, 2012

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Pubmed Data : Chem Biodivers. 2012 Apr ;9(4):817-28. PMID: 22492498

Article Published Date : Mar 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Breast Cancer, Melanoma

Pharmacological Actions : Antineoplastic Agents

[+]

Fucoidan has been shown to synergize with standard anti-cancer agents and reduces their side effects.Mar 13, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Mar 14 ;8(11):17887-17896. PMID: 28060735

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Pubmed Data : Chem Biol Interact. 2009 Oct 7;181(2):175-84. Epub 2009 Jul 3. PMID: 19577552

Article Published Date : Oct 07, 2009

Study Type : In Vitro Study

Additional Links

Substances : Gallic Acid

Diseases : Melanoma

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor

[+]

Gamma-tocotrienol has broad therapeutic activity against human melanoma cells. Jan 01, 2009

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Pubmed Data : Nutr Cancer. 2009;61(3):357-66. PMID: 19373609

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Mar 28 ;8(13):21674-21691. PMID: 28423510

Pubmed Data : Int Immunopharmacol. 2020 Sep 2 ;88:106932. Epub 2020 Sep 2. PMID: 32890791

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Transl Med. 2020 Feb 26 ;12(532). PMID: 32102933

Article Published Date : Feb 25, 2020

Study Type : Review

Additional Links

Substances : Vitamin C

Diseases : Breast Cancer, Cancers: All, Colorectal Cancer, Melanoma, Pancreatic Cancer

Pharmacological Actions : Immunomodulatory, Immunostimulatory

[+]

Highl doses of ascorbate up regulated 32 miRNAs 4-fold, mainly involved in tumor suppression and drug resistance.Dec 31, 2013

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Pubmed Data : Cell Mol Life Sci. 2006 Nov;63(22):2661-8. PMID: 17086378

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Pubmed Data : Mol Carcinog. 2017 01 ;56(1):49-61. Epub 2016 Feb 15. PMID: 26878440

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Melanoma, Skin Cancer

Pharmacological Actions : Antiproliferative

[+]

Inhibition of the STAT3 signalling pathway contributes to the anti-melanoma activities of shikonin. Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytother Res. 2017 Dec ;31(12):1858-1867. Epub 2017 Oct 13. PMID: 29027311

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

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Substances : Licorice

Diseases : Melanoma, Skin Cancer, Squamous cell carcinoma

Pharmacological Actions : Apoptotic

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Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells.Apr 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Rep. 2018 May ;39(5):2160-2170. Epub 2018 Mar 20. PMID: 29565458

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Licorice

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells.May 31, 2010

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Pubmed Data : Biometals. 2010 Jun ;23(3):485-92. Epub 2010 Feb 27. PMID: 20191307

Article Published Date : May 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lactoferrin

Diseases : Melanoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest

[+]

Click here to read the entire abstract

Pubmed Data : Int J Dermatol. 2008 May;47(5):448-56. PMID: 18412860

Article Published Date : May 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Sophora Flavescens

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells.Nov 30, 2017

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Pubmed Data : Nat Prod Res. 2017 Dec ;31(23):2712-2718. Epub 2017 Feb 16. PMID: 28278663

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Adlay

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Plant Extracts

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View the Evidence: 407 Abstracts with Melanoma Research

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Coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma, but increased lung cancer risk.Sep 25, 2016

Hypnotic drugs increase the risk of skin cancer.Sep 01, 2008

There is some evidence for the beneficial effects of regular coffee consumption on melanoma.Mar 31, 2016

Mineral oil exposures also contribute to the incidence and mortality of lung, melanoma, and possibly esophageal and stomach cancers and of non-Hodgkin's lymphoma in aerospace workers.Oct 01, 2005

A high vitamin D status may benefit prognosis in patients diagnosed with primary melanoma.Mar 22, 2017

consumption of caffeinated coffee was inversely associated with melanoma risk among men.Feb 19, 2017

Decreased vitamin D serum levels at melanoma diagnosis are associated with tumor ulceration and high tumor mitotic rate.Aug 27, 2019

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Gerson therapy may have therapeutic efficacy in the treatment of melanoma patients.Sep 01, 1995

Increased UVA exposures (indoor light) and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma.Apr 01, 2009

Melanoma skin cancer rates increased with decreased levels of vitamin D.Apr 30, 2017

Red and processed meat intake was inversely associated with melanoma risk in these two cohorts.Apr 22, 2018

Statin drug use is associated with increased incidence of melanoma and non-melanoma skin cancers. Oct 01, 2008

The authors of this study concluded that melanoma is associated with exposure to FM broadcasting.Jan 01, 2002

The Mediterranean Diet is associated with lower risk of skin cancer, Aug 05, 2019

The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides.Mar 31, 2016

The use of sildenafil may be associated with a higher risk of melanoma in men.May 31, 2014

These results suggest that coffee drinking may protect against liver, ovarian, thyroid and endometrial cancers and melanoma.May 17, 2018

An extract of Rosmarinus officinals L. was able to efficiently reduce the proliferation of the human melanoma A375 cells.Dec 31, 2014

Apigenin is a novel therapeutic candidate for melanoma.Feb 13, 2017

Blue LED irradiation induces apoptotic cell death by activating the mitochondria-mediated pathway and reduces the early growth rate of melanoma cells.Dec 31, 2014

Delta tocotrienol might represent an effective option for chemopreventive strategies for melanoma.Dec 31, 2015

The combination of HSP70 with phloretin could be a novel treatment for efficient immunotherapy of intractable cancers such as skin melanoma.Dec 31, 2015

The present study shows that lichen compounds demonstrated strong antioxidant, antimicrobial, and anticancer properties.Oct 14, 2012

Zerumbone has chemotherapeutic effects on human melanoma cells by altering mitochondrial function.Mar 31, 2017

Long-term survival and spontaneous tumor regression in stage IV melanoma.May 31, 2010

The use of Iscador as the sole modality for the adjuvant treatment of metastatic melanoma was extremely effective and very well tolerated achieving complete response and absence of all complaints.Apr 30, 2007

Viscum album extracts seems to have a positive potential in malignant cutaneous melanoma.Oct 31, 2017

Restoration of ascorbate from adequate to optimal physiological levels reduced tumor growth rates and moderated HIF-1 pathway activityJan 31, 2015

A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.Dec 31, 2014

Altogether these data suggest M1 is an efficient candidate for melanoma therapy.Jan 31, 2016

An isocaloric carbohydrate restriction diet and natural AMPK activating agents induce synergistic anticancer effects.Mar 18, 2015

Angelica sinensis has therapeutic effect against melanoma cells in the mouse experimental model.Mar 01, 2007

Antioxidant, anti-inflammatory and antiproliferative effects of the Vitis vinifera L. var. Fetească Neagră and pinot noir pomace extracts. Dec 31, 2019

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM.Nov 30, 2020

Approximately 67% of the initial number of mice survived with no tumor incidence based on macroscopic examination.May 29, 2006

Arctium lappa extract suppresses inflammation and inhibits melanoma progression.Jul 28, 2019

Ascorbate supplementation hinders metastasis, tumor growth and inflammatory cytokine secretion as well as enhanced encapsulation of tumors elicited by melanoma and breast cancer.Dec 31, 2012

Ascorbate supplementation might help reduce the severe side effects that arise from BETi therapy by reducing the dosage necessary for treatment.Nov 26, 2017

Assessment of antihyperlipidemic and antitumor effect of isolated active phytoconstituents from Apium graveolens.Dec 31, 2018

Bamboo leaf extract has immunopotentiating, antioxidant and antitumor activity. Jan 01, 2010

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Both ginseng saponins, 20(R)- and 20(S)-ginsenoside-Rg3, possess an ability to inhibit the lung metastasis of tumor cells.Aug 31, 1995

Cannabinoids as a potential new and novel treatment for melanoma.Feb 28, 2019

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Chrysin could be a potentially good candidate for future use in alternative anti-melanoma treatments.Jan 14, 2018

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Cinnamon extract induces melanoma tumor cell death in an in vivo model. Jun 03, 2010

Comparable efficacy of fisetin and vemurafenib for inhibiting melanoma growth was noted in this study.Oct 23, 2018

Cordyceps has significant therapeutic action against melanoma cell growth in mice with no adverse side effects.Dec 01, 2004

Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin.Aug 14, 2012

Crocin may exhibit significant melanoma tumor remission properties by positively modulating tumor growth related parameters.Dec 31, 2016

Curcumin and apigenin showed growth-suppressive and pro-apoptotic effects on melanoma cells.Oct 28, 2018

Curcumin effectively inhibited the proliferation of melanoma cells in vitro and in vivo.Nov 11, 2015

Curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition.Jan 31, 2015

Curcumin exhibits anti-melanoma activity. Mar 01, 2003

Curcumin inhibits the growth of choroidal melanoma. Jan 15, 2011

Delphinidin is a promising compound to prevent pathologies associated with generation of vascular network in tumorigenesis.Dec 31, 2014

Dietary oleuropein inhibits tumor angiogenesis and lymphangiogenesis in the B16F10 melanoma allograft model.Mar 30, 2017

Diosmin has a synergistic effect with interferon-alpha in inhibiting metastatic pulmonary melanoma. Jun 01, 2009

Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.Jan 31, 2013

Evaluation of antitumor potential of cashew gum extracted from Anacardium occidentale.Jun 30, 2020

Exposure to cancer exosomes altered the gene expression in the normal cells of mice. Dec 31, 2008

Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity.May 27, 2019

Galangin inhibits tumor growth and metastasis of B16F10 melanoma.Dec 31, 2012

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3.Dec 31, 2013

Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice modelJan 31, 2017

Ginsenoside Ro markedly suppresses the tumour growth of B16F10-transplanted tumours in vivo.Aug 16, 2019

Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity.Nov 30, 2015

Melanoma

View the Evidence:
407 Abstracts with Melanoma Research