Melanoma: Metastatic

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36 Substances Researched for Melanoma: Metastatic
NameACCKFocus
Diosmin 35Locked
Vitamin C45Locked
Sulforaphane23Locked
Anthocyanins22Locked
Blueberry22Locked
Broccoli12Locked
Curcumin12Locked
D-Limonene12Locked
EGCG (Epigallocatechin gallate)12Locked
Ellagic Acid12Locked
Phellinus Linteus12Locked
Polyphenols12Locked
Quercetin12Locked
Resveratrol12Locked
Rutin12Locked
Schisandra12Locked
Tangeretin 12Locked
Zedoary12Locked
African Basil11Locked
Basil11Locked
Chaga Mushroom (Inonotus obliquus)11Locked
Emodin11Locked
Feverfew11Locked
Fisetin11Locked
Grape Seed Extract11Locked
Kaempferol11Locked
Mangiferin11Locked
Phyllanthus amarus 11Locked
Phyllanthus niruri (Stonebreaker)11Locked
Phyllanthus urinaria11Locked
Potato11Locked
Red Wine Extract11Locked
Rosemaric Acid11Locked
Tocotrienol: Gamma11Locked
Tocotrienols11Locked
Vitamin E: Gamma-tocotrienol11Locked

View the Evidence:
31 Abstracts with Melanoma: Metastatic Research

[+]

Initial vitamin D deficiency and insufficient repletion is associated with a worse prognosis in patients with metastatic melanoma.Jan 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Jan 24 ;8(4):6873-6882. PMID: 28036288
Article Published Date : Jan 23, 2017
Study Type : Human Study
Additional Links
Diseases : Melanoma: Metastatic, Vitamin D Deficiency
Additional Keywords : Increased Risk
[+]

Complete spontaneous regression of a metastatic melanoma of the mandible.Nov 30, 2018

Pubmed Data : Int J Oral Maxillofac Surg. 2018 Dec ;47(12):1519-1522. Epub 2018 Jun 30. PMID: 29970290
Article Published Date : Nov 30, 2018
Study Type : Human: Case Report
Additional Links
Diseases : Melanoma: Metastatic
Additional Keywords : Spontaneous Tumor Regression
[+]

Metastatic melanoma with spontaneous regression, psoriasis and HLA-Cw6: case report and a hypothesis to explore.Jun 30, 2014

Pubmed Data : Tumori. 2014 Jul-Aug;100(4):144e-7e. PMID: 25296606
Article Published Date : Jun 30, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Melanoma: Metastatic, Psoriasis
Additional Keywords : Spontaneous Tumor Regression
[+]

D-limonene ihibits the metastatic progression of melanoma cells in mice. Sep 01, 2003

Pubmed Data : J Exp Clin Cancer Res. 2003 Sep;22(3):419-24. PMID: 14582701
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Malignant Melanoma, Melanoma: Metastatic
[+]

Diosmin has a synergistic effect with interferon-alpha in inhibiting metastatic pulmonary melanoma. Jun 01, 2009

Pubmed Data : Cancer Biother Radiopharm. 2009 Jun;24(3):347-52. PMID: 19538057
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Gomisin A has the potential to reduce metastatic melanoma through its anti-proliferative and anti-metastatic effects.Dec 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2019 Dec 7 ;68:153147. Epub 2019 Dec 7. PMID: 32028184
Article Published Date : Dec 06, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Schisandra
Diseases : Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Pharmacologic ascorbate was superior or equivalent to dacarbazine as an antitumor agent. Jun 24, 2015

Pubmed Data : Free Radic Biol Med. 2015 Jun 25. Epub 2015 Jun 25. PMID: 26119785
Article Published Date : Jun 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Antioxidants, Apoptotic, Chemotherapeutic, Cytotoxic
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
[+]

Resveratrol prevents inflammation-dependent hepatic melanoma metastasis.Jan 01, 2011

Pubmed Data : J Transl Med. 2011 ;9:59. Epub 2011 May 12. PMID: 21569399
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Inflammation, Liver Cancer, Liver Cancer: Metastatic, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Interleukin-18 down-regulation, Vascular Cell Adhesion Molecule-1 Inhibitor
[+]

Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals. Oct 01, 2006

Pubmed Data : Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID: 16600309
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Lung Cancer, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

The flavonoids tangeretin, rutin and especially diosmin inhibit the implantation, growth and invasion of metastatic melanoma. Aug 24, 2005

Pubmed Data : J Agric Food Chem. 2005 Aug 24;53(17):6791-7. PMID: 16104801
Article Published Date : Aug 24, 2005
Study Type : Animal Study
Additional Links
Substances : Diosmin , Rutin, Tangeretin
Diseases : Melanoma: Metastatic
[+]

The mushroom Phellinus linteus inhibits experimental metastasis of melanoma cells in mice. Apr 01, 2004

Pubmed Data : Gynecol Oncol. 2004 Apr;93(1):182-8. PMID: 15635158
Article Published Date : Apr 01, 2004
Study Type : Animal Study
Additional Links
Substances : Phellinus Linteus
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

Various plant polyphenols inhibit lung cancer caused by metastatic melanoma. Jul 16, 2009

Pubmed Data : Int Urol Nephrol. 2009 Jul 16. PMID: 7656234
Article Published Date : Jul 16, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Polyphenols, Quercetin
Diseases : Lung Cancer, Melanoma, Melanoma: Metastatic
[+]

Zedoariae rhizoma (Zedoary) inhibits melanoma cells and has an anti-metastatic action in mice. Oct 01, 2006

Pubmed Data : Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25. PMID: 16023317
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Zedoary
Diseases : Malignant Melanoma, Melanoma: Metastatic
Additional Keywords : Antimetastatic
[+]

A proteinase inhibitor from potato exhibits inhibitory activity against melanoma cell invasion in vitro.May 01, 2002

Pubmed Data : Biol Chem. 2002 May;383(5):839-42. PMID: 12108549
Article Published Date : May 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Potato
Diseases : Cancer Metastasis, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Serine Proteinase Inhibitors
Additional Keywords : Fungal Proteins
[+]

Aloe-emodin significantly reduced the proliferation, stemness and invasive potential of melanospheres.Jun 02, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jun 3 ;762:283-292. Epub 2015 Jun 3. PMID: 26048310
Article Published Date : Jun 02, 2015
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic, Immunomodulatory
Additional Keywords : Natural Substance/Drug Synergy
[+]

Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells.Jul 23, 2013

Pubmed Data : Phytochemistry. 2013 Jul 24. Epub 2013 Jul 24. PMID: 23890760
Article Published Date : Jul 23, 2013
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Blueberry
Diseases : Cancer Metastasis, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

Blueberry anthocyanin and anthocyanidin extracts inhibit the proliferation and trigger the apoptosis of B16-F10 cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2017 ;61(1):1325308. Epub 2017 Jun 19. PMID: 28680383
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Blueberry
Diseases : Melanoma: Metastatic
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Gamma-tocotrienol has broad therapeutic activity against human melanoma cells. Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(3):357-66. PMID: 19373609
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma, Tocotrienols, Vitamin E: Gamma-tocotrienol
Diseases : Malignant Melanoma, Melanoma, Melanoma: Metastatic
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Grape seed extract, red wine and especially diosmin, inhibit pulmonary metastatic melanoma. Oct 01, 2005

Pubmed Data : Histol Histopathol. 2005 Oct;20(4):1121-9. PMID: 16136495
Article Published Date : Oct 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Diosmin , Grape Seed Extract, Red Wine Extract
Diseases : Lung Cancer, Melanoma: Metastatic, Pulmonary Cancer
[+]

Highl doses of ascorbate up regulated 32 miRNAs 4-fold, mainly involved in tumor suppression and drug resistance.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2014 ;4:227. Epub 2014 Aug 25. PMID: 25202679
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Apoptotic, Cell cycle arrest, MicroRNA modulator
Additional Keywords : DNA Methyltransferase, Epigenetic Modification
[+]

Kaempferol impairs aerobic glycolysis against melanoma metastasis.Sep 14, 2022

Pubmed Data : Eur J Pharmacol. 2022 Sep 15 ;931:175226. Epub 2022 Aug 22. PMID: 36007607
Article Published Date : Sep 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Cancer Glycolysis
[+]

Mangiferin may be a potential therapeutic agent with a new mechanism of targeting NIK for the treatment of metastatic melanoma.Aug 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Sep 1 ;306:105-12. Epub 2016 Jul 11. PMID: 27417526
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Apoptotic, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Ocimum species have antimelanoma and radioprotective activity against metastatic melanoma cell line-induced metastasis.Mar 31, 2011

Pubmed Data : . PMID: 23603195
Article Published Date : Mar 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : African Basil, Basil
Diseases : Malignant Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Radioprotective
[+]

Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro.Feb 01, 2010

Pubmed Data : Melanoma Res. 2010 Feb;20(1):21-34. PMID: 19949351
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Apoptotic
[+]

Phyllanthus plant has the potential to inhibit tumour metastasis and angiogenesis through the suppression of MMP enzymes.May 20, 2015

Pubmed Data : Nutr Cancer. 2015 May 21:1-13. Epub 2015 May 21. PMID: 25996262
Article Published Date : May 20, 2015
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus , Phyllanthus niruri (Stonebreaker), Phyllanthus urinaria
Diseases : Melanoma, Melanoma: Metastatic, Prostate Cancer, Prostate Cancer: Metastatic
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Dose Response, Plant Extracts
[+]

Polysaccharides from chaga mushroom may suppress the invasion of highly metastatic melanoma cells.Sep 22, 2016

Pubmed Data : Mol Med Rep. 2016 Sep 23. Epub 2016 Sep 23. PMID: 27666322
Article Published Date : Sep 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus)
Diseases : Malignant Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor
[+]

Radiosensitizing effect of rosmarinic acid in metastatic melanoma B16F10 cells.Mar 31, 2014

Pubmed Data : Anticancer Res. 2014 Apr ;34(4):1913-21. PMID: 24692726
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Radiosensitizer
[+]

Silencing HIF-1α induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells.Jun 07, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Jun 8. Epub 2017 Jun 8. PMID: 28601635
Article Published Date : Jun 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Melanoma: Metastatic
Additional Keywords : Reactivation Of Tumor Suppressor Gene
[+]

Sulforaphane exhibits activity against metastatic melanoma cells. Jul 01, 2011

Pubmed Data : Drug Chem Toxicol. 2011 Jul ;34(3):332-40. PMID: 21649489
Article Published Date : Jul 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

The outcomes from this study demonstrated fisetin-nanostructured lipid carriers as an effective tool against melanoma.Dec 03, 2023

Pubmed Data : Mol Pharm. 2023 Dec 4 ;20(12):6035-6055. Epub 2023 Oct 31. PMID: 37906601
Article Published Date : Dec 03, 2023
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Melanoma: Metastatic
[+]

Vitamin C treatment increases 5hmC content in melanoma cells, while causing a decrease in tumor-cell invasiveness and clonogenic growth in soft agar.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Epigenetics. 2015 ;7(1):51. Epub 2015 Apr 29. PMID: 25977731
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Melanoma: Metastatic, Skin Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Epigenetic Modification

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