Mitochondrial Dysfunction

Name	AC	CK
Resveratrol	7	20
Coenzyme Q10	6	18
Carnitine	4	16
Curcumin	8	14
Quercetin	6	12
Melatonin	6	11
Urolithin A	1	10
Alpha-Lipoic Acid	5	9
Astaxanthin	5	7
Rice Bran	3	6
Butyrate	1	5
Ginkgo biloba	4	5
Vitamin E	3	5
Acetyl-l-carnitine	1	4
Biotin	1	4
DHA (Docosahexaenoic Acid)	2	4
Litchi	2	4
Niacin	1	4
Apigenin	2	3
EGCG (Epigallocatechin gallate)	2	3
Ginseng (Korean)	2	3
Ginsenosides	3	3
Gotu Kola	2	3
Huperzine	2	3
Sulforaphane	2	3
Thymoquinone	2	3
Alpha Linolenic Acid	1	2
Amla Fruit	1	2
Anthocyanins	1	2
Apple Polyphenols	1	2
Arachidonic Acid	1	2
Babchi	2	2
Blueberry	1	2
Cannabidiol	1	2
Citrulline	1	2
Garlic	1	2
Gingerol	1	2
Goji	1	2
Hydrogen Water	1	2
Krill	1	2
Naringenin	2	2
Nettle	1	2
Oleuropein	1	2
Onion	1	2
Plantago	2	2
Rutin	1	2
Semecarpus anacardium	1	2
Sesamol	1	2
Thymol	1	2
Vitamin K2	1	2
Vitexins	1	2
Astragaloside	1	1
Bacopa	1	1
Bai Zhu	1	1
Catechin	1	1
Crocin	1	1
Cyanidin 3-glucoside	1	1
Elderberry	1	1
Emodin	1	1
Ferulic acid	1	1
Folic Acid	1	1
Fucoidan	1	1
Grape Seed Extract	1	1
Hydroxytyrosol	1	1
Liquiritigenin	1	1
Luteolin	1	1
Lycopene	1	1
Mangiferin	1	1
Omega-3 Fatty Acids	1	1
Phlorotannins	1	1
Proanthocyanidins	1	1
Schisandra	1	1
Seaweed: Brown	1	1
Selenium	1	1
Spirulina	1	1
Tanshinone IIA	1	1
Tea	1	1
Vitamin B-12	1	1
Vitamin C	1	1
Vitamin D	1	1

Name	AC	CK
Statin Drugs	12	63
Simvastatin	9	31
Atorvastatin	3	21
Thimerosal	2	15
Glucose	3	12
Aluminum	3	5
Chlorine	1	5
Gadolinium	1	5
Aluminum oxide	2	4
Cell Phone Exposure	2	4
Pravastatin	2	4
Vaccine Adjuvants	2	4
Arsenic	2	3
Bisphenol A	2	3
Glyphosate formulations	2	3
Lamivudine	1	3
Lovastatin	2	3
Tacrolimus	2	3
Acetaminophen	1	2
Bisphenol S	1	2
Fluoxetine (trade name Prozac)	1	2
Heavy Metals	1	2
Isoproterenol	1	2
Nanoparticles	1	2
Paracetamol	1	2
Rotenone	1	2
Sodium Fluoride	1	2
Antipsychotic Drugs	1	1
Dichloro-diphenyl-trichloroethane (DDT)	1	1
Dichlorodiphenyldichloroethylene (DDE)	1	1
Drug: Ciprofloxacin	1	1
Mercury	1	1
Roundup (herbicide)	1	1

Name	AC	CK
Exercise	9	32
Dietary Modification: Low Carbohydrate/Ketogenic	3	14
Laser Treatment: Low-Level	1	2
Light Therapy	1	2
Infrared Light	1	1

Name	AC	CK
Electromagnetic Field Harms	7	26
Electromagnetic Radiation	7	26
Electromagnetic Radiation: 2.4 GHz	4	11
Microwave Radiation	4	11
Electromagnetic Radiation: 1.8 GHz	2	7
Mobile Phone Radiation	3	6
Vaccination: All	3	4
Wi-Fi Radiation	2	4
Blue Light (400−495 nm)	1	1

[+]

Mitochondrial dysfunction in autism spectrum disorders.Feb 29, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Psychiatry. 2012 Mar ;17(3):290-314. Epub 2011 Jan 25. PMID: 21263444

Article Published Date : Feb 29, 2012

Study Type : Meta Analysis, Review

Additional Links

Diseases : Autism Spectrum Disorders, Mitochondrial Dysfunction

[+]

A subpopulation of eight individuals from four of the families showed thimerosal hypersensitivity.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol. 2013 ;2013:801517. Epub 2013 Jun 9. PMID: 23843785

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Diseases : Autism Spectrum Disorders, Mitochondrial Dysfunction , Oxidative Stress

Problem Substances : Thimerosal

[+]

Amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Redox Rep. 2013 ;18(1):12-9. PMID: 23394493

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Pubmed Data : Bioelectromagnetics. 2013 Dec ;34(8):618-29. Epub 2013 Sep 25. PMID: 24217848

Article Published Date : Dec 01, 2013

Study Type : Human In Vitro

Additional Links

Diseases : Mitochondrial Dysfunction

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Cytotoxic

[+]

Radiofrequency-induced stress can damage mitochondria and induce elimination of damaged organelles via autophagy.Nov 01, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer. 2014 Nov 1 ;120(21):3418-25. Epub 2014 Jul 1. PMID: 24986120

Article Published Date : Nov 01, 2014

Study Type : Human In Vitro

Additional Links

Diseases : Mitochondrial Dysfunction

Additional Keywords : electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF, Mitochondria, Radio Frequency Electromagnetic Radiation Exposure

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

[+]

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Pubmed Data : Can J Cardiol. 2020 Apr 28. Epub 2020 Apr 28. PMID: 32360196

Article Published Date : Apr 27, 2020

Study Type : Human: Case Report

Additional Links

Diseases : Cardiomyopathy: Hypertrophic, Mitochondrial Diseases

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

L-carnitine improves mitochondrial enzymes in heart and skeletal muscle of aged rats.Jan 01, 2005

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Pubmed Data : Exp Aging Res. 2005 Jan-Mar;31(1):55-67. PMID: 15842073

Article Published Date : Jan 01, 2005

Study Type : Animal Study

Additional Links

Substances : Carnitine

Diseases : Aging, Mitochondrial Dysfunction

[+]

3G cell phone exposure impacts brain function by inducing oxidative stress, DNA fragmentation, and apoptosis through the p38 MAPK pathway.Mar 01, 2014

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Pubmed Data : Cell Biochem Biophys. 2014 Mar ;68(2):347-58. PMID: 23949848

Article Published Date : Mar 01, 2014

Study Type : Animal Study

Additional Links

Diseases : Mitochondrial Dysfunction , Neurologic Disorders, Oxidative Stress

Additional Keywords : Brain Function, Cell Phones, electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Microwave Radiation, Mobile Phone Radiation

Problem Substances : Cell Phone Exposure

Adverse Pharmacological Actions : Apoptotic, Genotoxic, Oxidant

[+]

6-Gingerol improves ectopic lipid accumulation, mitochondrial dysfunction, and insulin resistance in skeletal muscle of ageing rats.Dec 31, 2018

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Pubmed Data : Mol Nutr Food Res. 2019 03 ;63(6):e1800649. Epub 2019 Jan 3. PMID: 30575271

Alpha-linolenic acid helped in controlling glycaemia in rats induced to T2DM.Nov 05, 2020

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Pubmed Data : J Bioenerg Biomembr. 2020 Nov 6. Epub 2020 Nov 6. PMID: 33156468

Article Published Date : Nov 05, 2020

Study Type : Animal Study

Additional Links

Substances : Alpha Linolenic Acid

Diseases : Diabetes Mellitus: Type 2, Liver Damage, Mitochondrial Dysfunction

Additional Keywords : Risk Factors

[+]

Aluminum nanoparticles are more neurotoxic than micrometer aluminum.Jun 01, 2018

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Pubmed Data : Biol Trace Elem Res. 2018 Jun ;183(2):261-269. Epub 2017 Aug 30. PMID: 28856594

Article Published Date : Jun 01, 2018

Study Type : Animal Study

Additional Links

Diseases : Lipid Peroxidation, Mitochondrial Dysfunction , Oxidative Stress

Additional Keywords : Vaccine Research

Problem Substances : Aluminum oxide, Vaccine Adjuvants

Adverse Pharmacological Actions : Glutathione Down-Regulation, Oxidant

[+]

Amla prevents alcohol-induced brain mitochondrial dysfunction in rats.Jan 01, 2011

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Pubmed Data : J Med Food. 2011 Jan-Feb;14(1-2):62-8. Epub 2010 Dec 7. PMID: 21138366

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Endocrinol. 2019 Jan 1. Epub 2019 Jan 1. PMID: 30620716

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Diabetic Nephropathy, Mitochondrial Dysfunction

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.Jul 01, 2008

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Pubmed Data : Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arterioscler Thromb Vasc Biol. 2019 Sep ;39(9):1776-1786. Epub 2019 Jul 25. PMID: 31340670

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Diseases : Diesel Exhaust Particle Toxicity , Hyperlipidemia, Liver Steatosis, Mitochondrial Dysfunction

[+]

Docosahexaenoic acid attenuates mitochondrial alterations and oxidative stress leading to cell death Induced by very long-chain fatty acids.Jan 17, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2012 May 9. Epub 2012 May 9. PMID: 22573103

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Pubmed Data : Antioxidants (Basel). 2021 May 17 ;10(5). Epub 2021 May 17. PMID: 34067694

Article Published Date : May 16, 2021

Study Type : Animal Study

Additional Links

Substances : Carnosine, Coenzyme Q10

Diseases : Diabetes Mellitus: Type 2, Liver Steatosis, Mitochondrial Dysfunction

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism.Jul 21, 2019

Pubmed Data : Genes Nutr. 2015 Jan ;10(1):451. Epub 2014 Dec 27. PMID: 25542303

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Pubmed Data : Food Funct. 2016 Jan ;7(1):508-15. PMID: 26569420

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Microwave exposure decreases mitochondrial membrane potential, increases DNA fragmentation, and induces apoptosis via a caspase-3-dependent pathway in vitro.Jan 01, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Med Sci. 2014 ;11(5):426-35. Epub 2014 Mar 9. PMID: 24688304

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nanomedicine. 2013 Feb ;9(2):212-21. Epub 2012 Jun 9. PMID: 22687898

Article Published Date : Feb 01, 2013

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Pubmed Data : Anim Sci J. 2016 Feb 24. Epub 2016 Feb 24. PMID: 26916829

Article Published Date : Feb 23, 2016

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Mitochondrial Dysfunction , Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Phloretin attenuation of hepatic steatosis via an improvement of mitochondrial dysfunction.Dec 12, 2021

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Pubmed Data : Food Funct. 2021 Dec 13 ;12(24):12421-12433. Epub 2021 Dec 13. PMID: 34788781

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Pubmed Data : Blood Press. 2010 Jun;19(3):196-205. PMID: 20429690

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Cardiomegaly, Hypertension, Mitochondrial Dysfunction

Additional Keywords : Mitochondrial Biogenesis, Stilbenes

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Rice bran extract is a promising candidate nutraceutical for the prevention of age-related neurodegenerative diseases.Aug 03, 2015

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Pubmed Data : Nutr Neurosci. 2015 Aug 4. Epub 2015 Aug 4. PMID: 26241203

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Pubmed Data : J Ethnopharmacol. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28214539

Article Published Date : Feb 14, 2017

Study Type : In Vitro Study

Additional Links

Substances : Elderberry

Diseases : Mitochondrial Dysfunction , Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

A subgroup of patients with mitochondrial disease may be at risk of autistic regression with fever.Apr 01, 2010

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Pubmed Data : J Child Neurol. 2010 Apr ;25(4):429-34. Epub 2009 Sep 22. PMID: 19773461

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Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983

Article Published Date : Jan 01, 2011

Study Type : Review

Additional Links

Diseases : Congestive Heart Failure, Drug-Induced Nutrient Depletion: Statin Drugs, Lipid Peroxidation, Mitochondrial Dysfunction

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity

[+]

Bacopa monnieri is a potential therapeutic antioxidant to reduce oxidative stress and improve cognitive function.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:615384. Epub 2015 Aug 27. PMID: 26413126

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Pubmed Data : Nucleic Acids Res. 2018 Aug 31. Epub 2018 Aug 31. PMID: 30169847

Article Published Date : Aug 30, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Antibiotic Toxicity , Mitochondrial Dysfunction

Problem Substances : Drug: Ciprofloxacin

[+]

Coenzyme Q10 alleviates tacrolimus-induced mitochondrial dysfunction in kidney.Aug 19, 2019

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Pubmed Data : FASEB J. 2019 Aug 20:fj201900386RR. Epub 2019 Aug 20. PMID: 31431058

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Pubmed Data : Toxicol Lett. 2016 Jul 5 ;258:185-191. Epub 2016 Jul 5. PMID: 27392437

Article Published Date : Jul 04, 2016

Study Type : Review

Additional Links

Diseases : Mitochondrial Diseases, Mitochondrial Dysfunction , Mitochondrial Myopathies

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Gastrodin protects H9c2 cardiomyocytes against oxidative injury.Sep 30, 2020

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Pubmed Data : Acta Pharmacol Sin. 2020 Oct ;41(10):1314-1327. Epub 2020 Mar 12. PMID: 32203078

Article Published Date : Sep 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Gastrodin

Diseases : Mitochondrial Dysfunction , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective

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Ginkgo biloba extract protects against mitochondrial aging in the brain and in the liver. Sep 01, 2002

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2002 Sep;48(6):685-92. PMID: 12396080

Article Published Date : Sep 01, 2002

Study Type : Commentary

Additional Links

Substances : Ginkgo biloba

Diseases : Aging, Aging: Brain , Mitochondrial Dysfunction

[+]

Ginsenoside Rg3 attenuates sepsis-induced injury and mitochondrial dysfunction in liver.Aug 30, 2017

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Pubmed Data : J Pineal Res. 2012 Oct 12. Epub 2012 Oct 12. PMID: 23137057

Article Published Date : Oct 11, 2012

Study Type : Review

Additional Links

Substances : Melatonin

Diseases : Mitochondrial Diseases, Mitochondrial Dysfunction

Additional Keywords : Evolutionary Biology, Origin Of Melatonin

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Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter.Jul 03, 2019

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Pubmed Data : J Appl Toxicol. 2019 Jul 4. Epub 2019 Jul 4. PMID: 31273799

Article Published Date : Jul 03, 2019

Study Type : In Vitro Study

Additional Links

Diseases : Air Pollution Linked Toxicity, Mitochondrial Dysfunction

[+]

Mitochondrial effects of Ginkgo biloba extract.Jul 31, 2012

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Pubmed Data : Int Psychogeriatr. 2012 Aug ;24 Suppl 1:S18-20. PMID: 22784423

Article Published Date : Jul 31, 2012

Study Type : Review

Additional Links

Substances : Ginkgo biloba

Diseases : Aging: Brain , Mitochondrial Dysfunction , Oxidative Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

N-acetyl cysteine, selenium, and ascorbic acid rescue diabetic cardiac hypertrophy.Nov 29, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Endocrinol (Lausanne). 2019 ;10:122. Epub 2019 Mar 12. PMID: 30915030

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Diseases : Mitochondrial Dysfunction , Oxidative Stress

Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) , Dichlorodiphenyldichloroethylene (DDE)

[+]

P. corylifolia Linn seed extracts may have potential applications as therapeutic agents for treating neurodegenerative disease.Oct 02, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2014 Oct 3 ;14:370. Epub 2014 Oct 3. PMID: 25277760

Article Published Date : Oct 02, 2014

Study Type : In Vitro Study

Additional Links

Substances : Babchi

Diseases : Mitochondrial Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells.Nov 30, 2021

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Pubmed Data : Metab Brain Dis. 2021 Dec ;36(8):2377-2391. Epub 2021 Aug 2. PMID: 34338973

Pubmed Data : Eur Neuropsychopharmacol. 2018 Feb 12. Epub 2018 Feb 12. PMID: 29449054

Article Published Date : Feb 11, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Electron Transport Chain Deficiencies: Mitochondrial, Metabolic Syndrome X, Mitochondrial Dysfunction

Problem Substances : Antipsychotic Drugs

[+]

Selenium enriched spirulina protects INS-1E cells from hIAPP-induced cell death through preventing ROS overproduction, mitochondrial dysfunction.May 31, 2015

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Pubmed Data : Eur J Nutr. 2015 Jun ;54(4):509-22. Epub 2014 Aug 12. PMID: 25112514

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Pubmed Data : Eur J Pharmacol. 2019 Aug 15 ;857:172419. Epub 2019 May 25. PMID: 31136758

Article Published Date : Aug 14, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Advanced Glycation End products (AGE), Diabetic Retinopathy, Mitochondrial Dysfunction

Pharmacological Actions : Antioxidants

[+]

Targeting mitochondria with folic acid and vitamin B12 ameliorates nicotine mediated islet cell dysfunction.Aug 31, 2018

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Pubmed Data : Environ Toxicol. 2018 Sep ;33(9):988-1000. Epub 2018 Jul 4. PMID: 29972271

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Pubmed Data : Phytomedicine. 2018 Sep 19 ;54:224-230. Epub 2018 Sep 19. PMID: 30668372

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Pubmed Data : Mar Drugs. 2019 Sep 2 ;17(9). Epub 2019 Sep 2. PMID: 31480724

Article Published Date : Sep 01, 2019

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Mitochondrial Diseases, Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

These findings might recommend the use of ginsenoside Rg1 in preventing and treating isoflurane-induced neurotoxicity.Jan 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Environ Sci. 2015 Feb ;28(2):116-26. PMID: 25716562

Article Published Date : Jan 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Mitochondrial Dysfunction , Surgery: Anesthesiology

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

This article underpins the mechanisms of mitochondrial dysfunction in Alzheimer's disease. These include altered mitochondrial bioenergetics.Jan 11, 2016

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Pubmed Data : Mol Neurobiol. 2016 11 ;53(9):6078-6090. Epub 2015 Nov 4. PMID: 26537901

Article Published Date : Jan 11, 2016

Study Type : Review

Additional Links

Diseases : Mitochondrial Dysfunction , Oxidative Stress

[+]

This evidence suggests that mercury may be either causal or contributory in the brain pathology in autism spectrum disorder.Jan 01, 2012

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Pubmed Data : Acta Neurobiol Exp (Wars). 2012 ;72(2):113-53. PMID: 22810216

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Pubmed Data : Nutrients. 2015;7(7):5764-5782. Epub 2015 Jul 15. PMID: 26184304

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Ferulic acid

Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Mitochondrial Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Toxoplasma gondii infection is associated with mitochondrial dysfunction in-vitro.Dec 31, 2016

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Mitochondrial dysfunction in autism spectrum disorders.Feb 29, 2012

A subpopulation of eight individuals from four of the families showed thimerosal hypersensitivity.Dec 31, 2012

Amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.Dec 31, 2012

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin has been observed.May 01, 2007

Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions.Sep 30, 2007

Mitochondrial disease is prevalent among children with autism spectrum disorder and may correlate with severity.Jan 01, 2015

Mitochondrial dysfunction caused by statin contributes to endothelial dysfunction in patients with coronary artery disease.Jun 01, 2010

Mitochrondrial dysfunction associated with carnitine deficiency may play a role in idiopathic inflammatory myopathy. Dec 01, 2007

Resveratrol and exercise combined to treat functional limitations in late life.Oct 13, 2020

Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.Jul 01, 2005

Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction. Sep 01, 1996

Statins appear to cause muscle damage and impair oxidative metabolism.Jan 01, 2004

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.May 31, 2019

There is increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosisApr 15, 2008

These results expand our understanding of human adaptation to a ketogenic diet combined with exercise.Sep 27, 2020

Veterans with gulf war illness exhibit greater mitochondrial DNA damage which is consistent with mitochondrial dysfunction.Dec 31, 2016

1950 MHz induces mitochondrial damage and apoptosis in astrocytes.Jan 01, 2012

2.1 GHz microwave radiation decreases cell viability, reduces mitochondrial membrane potential, and results in cell death in breast fibroblast cells in vitro.Jan 01, 2013

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.Jan 01, 2018

Chlorine induces bioenergetic dysfunction associated with lung inflammation.Jul 31, 2015

Findings suggest that the epidemiological link between environmental mercury exposure and an increased risk of developing autism may be mediated through mitochondrial dysfunction.Dec 31, 2014

High glucose levels spike reactive oxygen species production by mitochondria and neuron apoptosis.Nov 01, 2002

Hyperglycemia induces mitochondrial dysfunction by a O-GlcNAc-independent mechanism.Apr 01, 2015

Low intensity static magnetic fields increase cellular free radical content and decrease mitochondrial membrane potential.Dec 01, 2013

Radiofrequency-induced stress can damage mitochondria and induce elimination of damaged organelles via autophagy.Nov 01, 2014

These results demonstrate a toxic effect of gadolinium-containing MRI contrast agents on mitochondrial respiratory function and cell viability.Jul 31, 2019

Developmental regression and mitochondrial dysfunction in a child with autism.Jan 31, 2006

Fatal exacerbation of peripheral neuropathy during lamivudine therapy has been reported.Aug 01, 2005

Simvastatin-induced lactic acidosis has been reported.Oct 01, 2002

Statins-induced MELAS syndrome has been reported. Jan 01, 2007

This case report suggests that a ketogenic diet may improve hypertrophic cardiomyopathy in the context of mitochondrial disease. Apr 27, 2020

L-carnitine improves mitochondrial enzymes in heart and skeletal muscle of aged rats.Jan 01, 2005

3G cell phone exposure impacts brain function by inducing oxidative stress, DNA fragmentation, and apoptosis through the p38 MAPK pathway.Mar 01, 2014

6-Gingerol improves ectopic lipid accumulation, mitochondrial dysfunction, and insulin resistance in skeletal muscle of ageing rats.Dec 31, 2018

A combination of mitochondrial targeting nutrients may improve skeletal mitochondrial dysfunction and exert hypoglycemic effects, without causing weight gain.Jan 01, 2008

A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats.Dec 31, 2019

A wolfberry (goji) preparation prevents prenatal stress-induced cognitive impairment of offspring rats and inhibits oxidative damage and mitochondrial dysfunction. Feb 05, 2010

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Acetyl-L-carnitine and lipoic acid decrease age-related oxidative insult in the mitochondria of the rat heart. Apr 01, 2002

Administration of rutin could effectively improve aging-related metabolic dysfunction.Jan 24, 2016

Alpha-linolenic acid helped in controlling glycaemia in rats induced to T2DM.Nov 05, 2020

Aluminum nanoparticles are more neurotoxic than micrometer aluminum.Jun 01, 2018

Amla prevents alcohol-induced brain mitochondrial dysfunction in rats.Jan 01, 2011

Apigenin ameliorated the obesity-induced skeletal muscle atrophy by attenuating mitochondrial dysfunction.Oct 01, 2017

Apple peel polyphenols reduce mitochondrial dysfunction in mice with DSS-induced ulcerative colitis.Mar 20, 2018

Arachidonic Acid and docosahexaenoic acid prevent alcoholic fatty liver and mitochondrial dysfunction in the ratAug 01, 2008

Astaxanthin attenuates d-galactose-induced brain aging in rats.Apr 27, 2020

Astaxanthin positively modulates age-associated mitochondrial dysfunction in healthy dogs.Oct 15, 2012

Bisdemethoxycurcumin protects small intestine from lipopolysaccharide-induced mitochondrial dysfunction.Dec 31, 2020

Carnitine induces autophagy and restores high-fat diet-induced mitochondrial dysfunction.Sep 27, 2017

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice.Jan 11, 2018

Citrulline/malate promotes aerobic energy production in human exercising muscle.Aug 01, 2002

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.Jan 31, 2019

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy.Dec 31, 2018

Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.Jul 01, 2008

Curcumin micelles might be a suitable formulation for the prevention of mitochondrial dysfunction in brain aging and neurodegeneration.Aug 04, 2015

Curcumin treatment attenuates ischemic stroke-induced brain injury via activation of SIRT1.Nov 26, 2015

Diesel exhaust induces mitochondrial dysfunction, hyperlipidemia, and liver steatosis.Aug 31, 2019

Docosahexaenoic acid attenuates mitochondrial alterations and oxidative stress leading to cell death Induced by very long-chain fatty acids.Jan 17, 2020

Effect of glyphosate on rat liver mitochondria in vivo.May 31, 1979

Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats.May 31, 2018

Exercise training can help minimize detrimental skeletal muscle aging deficits by improving mitochondrial protein quality control and biogenesis.May 09, 2012

Exercise training improves vascular mitochondrial function.Jan 28, 2016

Exercise training increases mitochondrial biogenesis in the brain.Aug 04, 2011

Garlic activates SIRT-3 to prevent cardiac oxidative stress and mitochondrial dysfunction in diabetes.Oct 31, 2016

Genistein could alleviate diabetic nephropathy through inhibiting MAPK/NF-κB pathway.Dec 31, 2021

Ginkgo biloba extract protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of mice.Jan 01, 2010

Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells.Jul 30, 2017

Glycine and N-Acetylcysteine) supplementation improves impaired mitochondrial fuel oxidation and lowers insulin resistance in patients with type 2 diabetes.Jan 12, 2022

Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.Feb 01, 2007

Krill oil counteracts the negative effects of a high-fat diet on mitochondrial energetic metabolism.Dec 31, 2014

L-carnosine stimulation of coenzyme Q10 biosynthesis promotes improved mitochondrial function and decreases hepatic steatosis in diabetic conditions.May 16, 2021

Mitochondrial Dysfunction

View the Evidence:
223 Abstracts with Mitochondrial Dysfunction Research