Mitochondrial Myopathies

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1 Substances Researched for Mitochondrial Myopathies

Name	AC	CK	Focus
Schisandra	1	1

8 Problem Substances Researched for Mitochondrial Myopathies

Name	AC	CK
Statin Drugs	6	43
Simvastatin	5	15
Atorvastatin	2	12
Lovastatin	2	11
Cerivastatin	1	2
Fluvastatin	1	2
Fluoxetine (trade name Prozac)	1	1
Statin	1	1

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD

View the Evidence:
11 Abstracts with Mitochondrial Myopathies Research

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[+]

Statin drugs impair mitochondrial function and decrease ubiquinone (coenzyme Q10) levels. Jan 01, 2009

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Pubmed Data : Toxicol Mech Methods. 2009 Jan;19(1):44-50. PMID: 19778232

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Mitochondrial Myopathies, Statin-Induced Pathologies

Problem Substances : Lovastatin, Statin Drugs

[+]

Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.Jul 01, 2005

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Pubmed Data : Clin Pharmacol Ther. 2005 Jul;78(1):60-8. PMID: 16003294

Article Published Date : Jul 01, 2005

Study Type : Human Study

Additional Links

Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Myopathies

Problem Substances : Atorvastatin, Simvastatin, Statin Drugs

[+]

Statin-related myopathy is associated wtih low muscle levels of coenzyme Q10. Nov 01, 2005

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Pubmed Data : Arch Neurol. 2005 Nov;62(11):1709-12. PMID: 16286544

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Diseases : Mitochondrial Myopathies, Myopathy, Statin-Induced Pathologies

Problem Substances : Statin Drugs

[+]

Statins appear to cause muscle damage and impair oxidative metabolism.Jan 01, 2004

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Pubmed Data : J Submicrosc Cytol Pathol. 2004 Jan ;36(1):85-9. PMID: 15311678

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Myopathies, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

Lipophilic statin drugs are associated with impaired skeletal muscle mitochondria.Oct 01, 2006

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Pubmed Data : Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25. PMID: 17013560

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Diseases : Mitochondrial Myopathies, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Cerivastatin, Fluvastatin, Simvastatin, Statin Drugs

[+]

Fluoxetine may harm mitochondria.Jul 04, 2016

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Pubmed Data : Toxicol Lett. 2016 Jul 5 ;258:185-191. Epub 2016 Jul 5. PMID: 27392437

Article Published Date : Jul 04, 2016

Study Type : Review

Additional Links

Diseases : Mitochondrial Diseases, Mitochondrial Dysfunction , Mitochondrial Myopathies

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Schisandra berry's reputation as "Qi-invigorating" has a biochemical basis in the fact that it improves mitochondrial antioxidant status. Jan 01, 2006

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Pubmed Data : Am J Chin Med. 2006;34(2):171-6. PMID: 16552829

Article Published Date : Jan 01, 2006

Study Type : Commentary

Additional Links

Substances : Schisandra

Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies

Additional Keywords : Qi-Invigoration

[+]

Simvastatin-induced inhibition of mitochondrial respiration is likely associated myotoxicity. Aug 04, 2011

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Pubmed Data : Biochim Biophys Acta. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21839782

Article Published Date : Aug 04, 2011

Study Type : In Vitro Study

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Mitochondrial Myopathies

Problem Substances : Simvastatin

Adverse Pharmacological Actions : Myotoxicity

[+]

Statin drugs can act directly on mitochondria either in vivo or in vitro inducing permeability transition, which is a process involved in cell death.Feb 15, 2006

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Pubmed Data : Toxicology. 2006 Feb 15 ;219(1-3):124-32. Epub 2005 Dec 15. PMID: 16343726

Article Published Date : Feb 15, 2006

Study Type : Review

Additional Links

Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies

Problem Substances : Lovastatin, Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Cytotoxic

[+]

Statins alter mitochondrial function which may be associated with myotoxicity in skeletal muscle.Apr 15, 2005

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Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):1067-75. PMID: 15752763

Article Published Date : Apr 15, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Statin-Induced Pathologies

Problem Substances : Simvastatin

Adverse Pharmacological Actions : Myotoxicity

[+]

Statins may have mitochondria and cardiac cell damaging properties. Feb 01, 2024

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Pubmed Data : Basic Res Cardiol. 2024 Feb 2. Epub 2024 Feb 2. PMID: 38305903

Article Published Date : Feb 01, 2024

Study Type : In Vitro Study

Additional Links

Diseases : Cardiovascular Disease, Mitochondrial Myopathies

Problem Substances : Statin

Adverse Pharmacological Actions : Cardiotoxic

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD