Morphine Tolerance/Dependence

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41 Substances Researched for Morphine Tolerance/Dependence
NameACCKFocus
Delta-tetrahydrocannabinol (THC)324Locked
Cannabinoids 222Locked
Magnesium Sulfate110Locked
Testosterone110Locked
Cannabidiol36Locked
Berberine24Locked
Curcumin24Locked
Nigella sativa (aka Black Seed)24Locked
Palmitoylethanolamide 24Locked
Sinomenine24Locked
Ashwagandha12Locked
Bergamot12Locked
Cannabis12Locked
Chamomile12Locked
Cumin22Locked
EGCG (Epigallocatechin gallate)12Locked
Ellagic Acid12Locked
Emodin12Locked
Garlic12Locked
Ginger12Locked
Ginkgo biloba12Locked
Ginseng (Korean)12Locked
Ginsenosides12Locked
Grape Seed Extract12Locked
Huperzine12Locked
Hydrogen Water12Locked
Kratom12Locked
Melatonin12Locked
Oats12Locked
Paeoniflorin12Locked
Passion Flower12Locked
Resveratrol12Locked
Rhodiola (Tibetan Ginseng)12Locked
Rose: Essential Oil12Locked
Saffron12Locked
Sage12Locked
Shilajit12Locked
Thymoquinone12Locked
Valerian12Locked
ibogaine12Locked
Sulforaphane11Locked
4 Problem Substances Researched for Morphine Tolerance/Dependence
NameACCKFocus
Fructose24Locked
Morphine24Locked
Analgesic: Non-opioid12Locked
Glucose12Locked
6 Therapeutic Actions Researched for Morphine Tolerance/Dependence
NameACCKFocus
Acupuncture230Locked
Hormone Replacement Therapy110Locked
Electroacupuncture24Locked
Hyperbaric Treatment24Locked
Photobiomodulation12Locked
Qigong12Locked

View the Evidence:
62 Abstracts with Morphine Tolerance/Dependence Research

[+]

Acupuncture at HT7 can attenuate anxiety-like behaviour induced by withdrawal from chronic morphine treatment.Nov 06, 2017

Pubmed Data : Neurosci Lett. 2017 Nov 7 ;664:38-42. Epub 2017 Nov 7. PMID: 29126776
Article Published Date : Nov 06, 2017
Study Type : Meta Analysis
Additional Links
Diseases : Morphine Tolerance/Dependence
Therapeutic Actions : Acupuncture
Pharmacological Actions : Anti-Anxiety Agents
[+]

The median effective dose of morphine administered in combination with THC is 3.6 times lower than of morphine alone.Mar 21, 2017

Pubmed Data : Neuropsychopharmacology. 2017 Mar 22. Epub 2017 Mar 22. PMID: 28327548
Article Published Date : Mar 21, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : Cannabinoids , Delta-tetrahydrocannabinol (THC)
Diseases : Morphine Tolerance/Dependence, Opioid Tolerance/Dependence
Additional Keywords : Medication Reduction
[+]

Acupuncture may have therapeutic value in treating morphine addiction. Feb 01, 2010

Pubmed Data : Neurol Res. 2010 Feb;32 Suppl 1:107-10. PMID: 20034457
Article Published Date : Feb 01, 2010
Study Type : Human Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Therapeutic Actions : Acupuncture
[+]

Hormone replacement therapy may have therapeutic value in morphine-induced hypogonadic male chronic pain patients.Jan 01, 2011

Pubmed Data : Reprod Biol Endocrinol. 2011;9:26. Epub 2011 Feb 18. PMID: 21332999
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Testosterone
Diseases : Drug-Induced Toxicity , Hypogonadism, Morphine Tolerance/Dependence, Opiate Addiction/Withdrawal, Testosterone: Too Low
Therapeutic Actions : Hormone Replacement Therapy
Pharmacological Actions : Analgesics
[+]

Magnesium sulphate increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.Nov 20, 2016

Pubmed Data : Pain Manag. 2016 Nov 21. Epub 2016 Aug 21. PMID: 27866449
Article Published Date : Nov 20, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium Sulfate
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Natural Substance Synergy
[+]

Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.Sep 30, 2009

Pubmed Data : Neuropsychopharmacology. 2009 Oct ;34(11):2469-76. Epub 2009 Jun 24. PMID: 19553915
Article Published Date : Sep 30, 2009
Study Type : Animal Study
Additional Links
Substances : Cannabis
Diseases : Morphine Tolerance/Dependence, Prenatal Chemical Exposures
[+]

Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice.Dec 31, 2016

Pubmed Data : Arch Pharm Res. 2017 Jan ;40(1):106-111. Epub 2016 Oct 28. PMID: 27796936
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Glutathione Upregulation , Hepatoprotective
[+]

Ashwaganda reduces morphine tolerance and dependence in miceAug 01, 1997

Pubmed Data : J Ethnopharmacol. 1997 Aug;57(3):213-7. PMID: 9292416
Article Published Date : Aug 01, 1997
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Morphine Tolerance/Dependence, Opiate Tolerance
[+]

Attenuation of morphine withdrawal signs by low level laser therapy in rats.Jan 22, 2009

Pubmed Data : Behav Brain Res. 2009 Jan 23 ;196(2):268-70. Epub 2008 Sep 24. PMID: 18926854
Article Published Date : Jan 22, 2009
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Therapeutic Actions : Photobiomodulation
[+]

Berberine can reduce the acquisition and reinstatement of morphine-induced conditioned place preference.Feb 29, 2016

Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Morphine Tolerance/Dependence
[+]

Bilobalide assuages morphine-induced addiction in hippocampal neuron cells.Jun 30, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Jul ;34(7):e22493. Epub 2020 Apr 21. PMID: 32319158
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : MicroRNA modulator
Additional Keywords : Plant Extracts
[+]

Cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.Aug 08, 2017

Pubmed Data : Planta Med. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28793355
Article Published Date : Aug 08, 2017
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Morphine Tolerance/Dependence
[+]

Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model.Oct 27, 2022

Pubmed Data : Behav Brain Res. 2022 Oct 28 ;435:114076. Epub 2022 Aug 24. PMID: 36028000
Article Published Date : Oct 27, 2022
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cannabidiol may be clinically useful in attenuating the rewarding effects of opioids.Feb 28, 2013

Pubmed Data : Addict Biol. 2013 Mar ;18(2):286-96. Epub 2012 Aug 2. PMID: 22862835
Article Published Date : Feb 28, 2013
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Morphine Tolerance/Dependence
Problem Substances : Analgesic: Non-opioid
[+]

Co-administration Bergamot polyphenolic fractions can be an important therapeutic approach to restore opioids analgesic efficacy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0156039. Epub 2016 May 26. PMID: 27227548
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bergamot
Diseases : Hyperalgesia, Morphine Tolerance/Dependence
Additional Keywords : Plant Extracts
[+]

Co-administration of a low dose of morphine with Delta9-THC increased antinociception and 5-hydroxytryptamine levels.Jan 31, 2004

Pubmed Data : Eur J Neurosci. 2004 Feb ;19(3):678-86. PMID: 14984418
Article Published Date : Jan 31, 2004
Study Type : Animal Study
Additional Links
Substances : Delta-tetrahydrocannabinol (THC)
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Antinoceceptive
[+]

Cumin reduces morphine-induced conditioned place preference (CPP) in mice.Sep 01, 1999

Pubmed Data : Wound Repair Regen. 1999 Sep-Oct;7(5):362-74. PMID: 18950682
Article Published Date : Sep 01, 1999
Study Type : Animal Study
Additional Links
Substances : Cumin
Diseases : Morphine Tolerance/Dependence
[+]

Curcumin blocks chronic morphine analgesic tolerance and positively modulates brain chemistry. Jan 07, 2009

Pubmed Data : Neuroreport. 2009 Jan 7;20(1):63-8. PMID: 19033880
Article Published Date : Jan 07, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Epigenetic Modification
[+]

Curcumin may attenuate opioid tolerance and dependence by suppressing CaMKIIα activity.Feb 28, 2015

Pubmed Data : J Pharmacol Exp Ther. 2015 Mar ;352(3):420-8. Epub 2014 Dec 16. PMID: 25515789
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Dose Response
[+]

Delay of morphine tolerance by palmitoylethanolamide.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:894732. Epub 2015 Mar 22. PMID: 25874232
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effect of sinomenine on the morphine-dependence and related neural mechanisms in mice.Nov 30, 2017

Pubmed Data : Neurochem Res. 2017 Dec ;42(12):3587-3596. Epub 2017 Nov 8. PMID: 29116553
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Morphine Tolerance/Dependence
[+]

EGCG has strong pharmacological activity against the development of morphine dependence. Sep 01, 2007

Pubmed Data : Arch Pharm Res. 2007 Sep;30(9):1111-5. PMID: 17958328
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Morphine Tolerance/Dependence
[+]

Electroacupuncture intervention can relieve pain and morphine tolerance in bone cancer pain.Mar 24, 2019

Pubmed Data : Zhen Ci Yan Jiu. 2019 Mar 25 ;44(3):161-9. PMID: 30945497
Article Published Date : Mar 24, 2019
Study Type : Animal Study
Additional Links
Diseases : Bone Cancer, Cancer: Pain , Morphine Tolerance/Dependence
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics
[+]

Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence.Oct 14, 2014

Pubmed Data : Eur J Pharmacol. 2014 Oct 15 ;741:272-80. Epub 2014 Aug 30. PMID: 25179576
Article Published Date : Oct 14, 2014
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Natural Substance/Drug Synergy
[+]

Emodin relieves morphine-stimulated BV2 microglial activation and inflammation.May 14, 2024

Pubmed Data : Neuroreport. 2024 May 15 ;35(8):518-528. Epub 2024 Apr 8. PMID: 38597275
Article Published Date : May 14, 2024
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Brain: Microglial Activation, Inflammation, Morphine Tolerance/Dependence
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Fructose is capable of increasing brain morphine levels following co-administration, as well as exhibiting opioid properties.Jan 01, 1991

Pubmed Data : Life Sci. 1991 ;49(10):727-34. PMID: 1875782
Article Published Date : Jan 01, 1991
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Food Opioids, Fructose-Opiate Connection
Problem Substances : Fructose
[+]

GABAergic activity induced by flavonoids from Rosa damascena essential oil can alleviate signs of morphine withdrawal.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2013 ;12(3):357-61. PMID: 24250642
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Rose: Essential Oil
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : GABA Modulators
[+]

Ginger (Zingiber officinale Roscoe) elicits antinociceptive properties and potentiates morphine-induced analgesia in the rat radiant heat tail-flick test.Nov 30, 2010

Pubmed Data : J Med Food. 2010 Dec ;13(6):1397-401. PMID: 21091253
Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Morphine Tolerance/Dependence, Pain
Pharmacological Actions : Analgesics
Additional Keywords : Drug Synergy, Phytotherapy, Plant Extracts
[+]

Grape seed proanthocyanidin extract showed a significant anti-hyperalgesic and anti-nociceptive effect in rats.Sep 16, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Sep 17. Epub 2015 Sep 17. PMID: 26378488
Article Published Date : Sep 16, 2015
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Morphine Tolerance/Dependence, Neuropathic Pain, Oxidative Stress
Pharmacological Actions : Antinoceceptive , Antioxidants
Additional Keywords : Plant Extracts
[+]

Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Apr ;13(4):1584-1591. Epub 2017 Feb 2. PMID: 28413513
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Morphine Tolerance/Dependence
Problem Substances : Morphine
[+]

Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.May 14, 2017

Pubmed Data : Neuropharmacology. 2017 May 15 ;118:199-208. Epub 2017 Mar 28. PMID: 28359771
Article Published Date : May 14, 2017
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Anxiety, Morphine Tolerance/Dependence
Pharmacological Actions : Anti-Anxiety Agents
[+]

Hyperbaric oxygen can effectively alleviate withdrawal symptoms induced by morphine dependence.Jan 07, 2018

Pubmed Data : Neurochem Res. 2018 Jan 8. Epub 2018 Jan 8. PMID: 29313212
Article Published Date : Jan 07, 2018
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Therapeutic Actions : Hyperbaric Treatment
[+]

Hyperbaric oxygen therapy can suppress physical signs of withdrawal syndrome in morphine-dependent mice.Aug 13, 2016

Pubmed Data : Brain Res. 2016 Aug 14. Epub 2016 Aug 14. PMID: 27534375
Article Published Date : Aug 13, 2016
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Therapeutic Actions : Hyperbaric Treatment
[+]

Ibogaine attenuation of morphine withdrawal in mice.Aug 01, 2003

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):781-5. PMID: 12921910
Article Published Date : Aug 01, 2003
Study Type : Animal Study
Additional Links
Substances : ibogaine
Diseases : Morphine Tolerance/Dependence
[+]

Inhibitory effect of berberine on morphine tolerance and hyperalgesia.Sep 30, 2023

Pubmed Data : J Tradit Chin Med. 2023 Oct ;43(5):915-924. PMID: 37679979
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Hyperalgesia, Morphine Tolerance/Dependence
Pharmacological Actions : Neuroprotective Agents
[+]

Korean traditional music suppresses morphine-seeking behaviour via GABA receptor pathway.Apr 30, 2018

Pubmed Data : Neurosci Lett. 2018 May 1 ;674:81-87. Epub 2018 Mar 17. PMID: 29559416
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Problem Substances : Morphine
[+]

M. speciosa alkaloid extract attenuated the severity of naloxone-precipitated morphine withdrawal symptoms.Aug 16, 2017

Pubmed Data : J Ethnopharmacol. 2017 Aug 17 ;208:129-137. Epub 2017 Jul 5. PMID: 28687506
Article Published Date : Aug 16, 2017
Study Type : Animal Study
Additional Links
Substances : Kratom
Diseases : Morphine Tolerance/Dependence
[+]

Matricaria chamomilla extract inhibits the development of morphine dependence and withdrawal symptoms in rats. May 01, 2003

Pubmed Data : J Pharmacol Sci. 2003 May;92(1):50-5. PMID: 12832855
Article Published Date : May 01, 2003
Study Type : Animal Study
Additional Links
Substances : Chamomile
Diseases : Morphine Tolerance/Dependence
[+]

Melatonin can be useful as a therapeutic adjuvant for patients under long-term opioid treatment for pain relief.Mar 20, 2016

Pubmed Data : Life Sci. 2016 Mar 21. Epub 2016 Mar 21. PMID: 27012766
Article Published Date : Mar 20, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Brain Inflammation , Morphine Tolerance/Dependence
Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Down-Regulation
[+]

N-palmitoylethanolamide attenuates negative emotions induced by morphine withdrawal in mice.Oct 14, 2024

Pubmed Data : Neurosci Lett. 2024 Oct 15 ;841:137944. Epub 2024 Aug 21. PMID: 39154843
Article Published Date : Oct 14, 2024
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Depression, Morphine Tolerance/Dependence
[+]

Nigella sativa extract affects conditioned place preference induced by morphine in rats, indicating it may have therapeutic value in treating morphine dependence and/or tolerance.Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anc Sci Life. 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Morphine Tolerance/Dependence
[+]

Nigella sativa oil appears to have a therapeutic potential in opioid tolerance and dependence.Sep 30, 2010

Pubmed Data : Neurochem Res. 2010 Oct ;35(10):1557-65. Epub 2010 Jun 15. PMID: 20552271
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Morphine Tolerance/Dependence, Oxidative Stress
Pharmacological Actions : Nitric Oxide Inhibitor
Additional Keywords : Plant Oils
[+]

O-1602 decreased acquisition and expression of morphine CPP and inhibited development of morphine-induced physical dependence.May 31, 2016

Pubmed Data : Pharmacol Rep. 2016 Jun ;68(3):592-7. Epub 2016 Jan 11. PMID: 26971034
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabinoids
Diseases : Morphine Tolerance/Dependence
[+]

Oats exhibit opioid activity. Feb 01, 1975

Pubmed Data : J Pharm Pharmacol. 1975 Feb;27(2):92-8. PMID: 237083
Article Published Date : Feb 01, 1975
Study Type : Animal Study
Additional Links
Substances : Oats
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics: Opioid
Additional Keywords : Pharmacology of Cereal Grasses, Plant Extracts
[+]

Red ginseng extracts and their ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2016 Oct ;40(4):445-452. Epub 2016 Aug 21. PMID: 27746699
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginseng (Korean), Ginsenosides
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Plant Extracts
[+]

Resveratrol restores the antinociceptive effect of morphine by reversing morphine infusion induced spinal cord neuroinflammation and increase in TNFR1 expression.Jun 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2015 Jun 12. Epub 2015 Jun 12. PMID: 26078221
Article Published Date : Jun 11, 2015
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Brain Inflammation , Morphine Tolerance/Dependence, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Disease Reversal, Gene Expression
[+]

Rhodiola rosea has a beneficial effect on the acquisition and expression of morphine tolerance and dependence in mice.Feb 08, 2010

Pubmed Data : J Psychopharmacol. 2010 Feb 8. Epub 2010 Feb 8. PMID: 20142299
Article Published Date : Feb 08, 2010
Study Type : Animal Study
Additional Links
Substances : Rhodiola (Tibetan Ginseng)
Diseases : Morphine Tolerance/Dependence, Opiate Addiction/Withdrawal, Opiate Tolerance
[+]

Saffron stigma reduces symptoms of morphine-induced dependence and spontaneous withdrawal.Mar 03, 2021

Pubmed Data : Am J Drug Alcohol Abuse. 2021 Mar 4 ;47(2):170-181. Epub 2021 Jan 26. PMID: 33497577
Article Published Date : Mar 03, 2021
Study Type : Animal Study
Additional Links
Substances : Saffron
Diseases : Morphine Tolerance/Dependence
[+]

Salvia officinalis has antinociceptive effects and may decrease tolerance and dependence induced by repeated morphine administration.Dec 31, 2014

Pubmed Data : Am J Drug Alcohol Abuse. 2015 ;41(5):405-13. PMID: 26337199
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sage
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Antinoceceptive
[+]

Selective suppression of microglial activation by paeoniflorin attenuates morphine tolerance.Jul 31, 2015

Pubmed Data : Eur J Pain. 2015 Aug ;19(7):908-19. Epub 2014 Nov 16. PMID: 25400125
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Brain: Microglial Activation, Morphine Tolerance/Dependence
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Shilajit prevents the development of tolerance to morphine in mice. Jun 17, 2005

Pubmed Data : Biochem Biophys Res Commun. 2005 Jun 17;331(4):1515-21. PMID: 11268125
Article Published Date : Jun 17, 2005
Study Type : Animal Study
Additional Links
Substances : Shilajit
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics
Additional Keywords : Drug Synergy, Plant Extracts
[+]

Sinomenine protects against morphine dependence.Sep 16, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 17 ;23(9). Epub 2018 Sep 17. PMID: 30227624
Article Published Date : Sep 16, 2018
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Exosomes
[+]

Sintocalmy, a Passiflora incarnata based herbal, attenuates morphine withdrawal.Apr 30, 2021

Pubmed Data : Neurochem Res. 2021 May ;46(5):1092-1100. Epub 2021 Feb 5. PMID: 33544325
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Passion Flower
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Plant Extracts
[+]

THC can enhance the antinociception and tolerance and some of the dependence effects of morphine.Apr 30, 2016

Pubmed Data : J Pharmacol Exp Ther. 2016 May ;357(2):357-66. Epub 2016 Mar 2. PMID: 26937020
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Delta-tetrahydrocannabinol (THC)
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Antinoceceptive
[+]

The antagonism of morphine-induced antinociception by glucose and fructose is due to a direct effect of these sugars or their metabolic products within the central nervous system.Feb 09, 1988

Pubmed Data : Eur J Pharmacol. 1988 Feb 9 ;146(2-3):337-40. PMID: 3371404
Article Published Date : Feb 09, 1988
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics
Additional Keywords : Food Opioids, Fructose-Opiate Connection
Problem Substances : Fructose, Glucose
[+]

The application of external Qigong therapy appears to reduce withdrawal syndrome and dependence in mice. Dec 01, 2003

Pubmed Data : J Altern Complement Med. 2003 Dec;9(6):827-35. PMID: 14736354
Article Published Date : Dec 01, 2003
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Therapeutic Actions : Qigong
[+]

Thymoquinone prevents the development of tolerance and dependence to morphine.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):55-66. PMID: 27247922
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Morphine Tolerance/Dependence
[+]

Valerian root appears to reduce the symptoms of morphine withdrawal syndrome. Jun 01, 2006

Pubmed Data : Addict Biol. 2006 Jun;11(2):145-51. PMID: 16800827
Article Published Date : Jun 01, 2006
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Morphine Tolerance/Dependence
[+]

When used in combination with electroacupuncture, morphine could result in improving analgesic effects and reducing tolerance.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:8028474. Epub 2016 Sep 8. PMID: 27672401
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Cancer: Pain , Morphine Tolerance/Dependence
Therapeutic Actions : Electroacupuncture
[+]

Dopamine, morphine and nitric oxide form an evolutionary signaling triad. Jun 01, 2010

Pubmed Data : CNS Neurosci Ther. 2010 Jun;16(3):e124-37. Epub 2009 Nov 13. PMID: 19912274
Article Published Date : Jun 01, 2010
Study Type : Review
Additional Links
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Endogenous Morphine Production
[+]

Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain.Oct 14, 2021

Pubmed Data : Eur J Pharmacol. 2021 Oct 15 ;909:174412. Epub 2021 Aug 8. PMID: 34375671
Article Published Date : Oct 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Hyperalgesia, Morphine Tolerance/Dependence
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

The essential oil of Cumin attenuates the development of morphine tolerance and dependence in mice.Aug 01, 2008

Pubmed Data : Neurosci Lett. 2008 Aug 1;440(2):134-9. Epub 2008 May 22. PMID: 18550281
Article Published Date : Aug 01, 2008
Additional Links
Substances : Cumin
Diseases : Morphine Tolerance/Dependence

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